JP2020093480A - Laminate for blister pack, blister pack using the same, and blister pack package - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a laminate for a blister pack in which molding defects are less likely to occur even when an unstretched polypropylene film is used as a base material. A blister pack laminate (B) of the present invention has a blister pack laminate (B) having a base film (10), an extruded resin layer (20), and an absorbent film (30) in this order. The base film (10) contains a non-stretched polypropylene film, the extruded resin layer (20) contains a polyolefin resin, and the absorbent film (30) is an outer skin layer (31). It has an absorption layer (32) and an inner skin layer (33), the absorption layer (32) contains a polyethylene resin and an absorbent, and the outer skin layer (31) and the inner skin layer (33) are Each contains 15% by weight or more and less than 80% by weight of a polyethylene-based resin, and 20% by weight or more and 85% by weight or less of a polypropylene-based resin, and 5% by weight or more of block polypropylene. [Selection diagram] Fig. 2

Description

The present invention relates to a blister pack laminate, a blister pack using the laminate, and a blister pack package. In particular, the present invention relates to a blister pack laminate that does not cause defective molding even when a pocket having a depth is formed for packaging a large drug, a blister pack using the same, and a blister pack package.

The powdery drug is enclosed in a thin paper bag, a film bag, or the like, while the drug such as tablets or capsules is enclosed in a blister pack called PTP (press-through pack). By pressing the medicine enclosed in the blister pack with a finger, the sheet-shaped lid material can be broken and the medicine can be taken out.

A drug may change its medicinal properties by absorbing water. Therefore, conventionally, a desiccant such as silica gel is enclosed in an outer bag that encloses the blister pack. However, the work of putting the desiccant into the outer bag is time-consuming, and there is a risk that it may be accidentally ingested or accidentally eaten. Further, after opening the outer bag, there is also a problem that the inside of the blister pack cannot be kept at a low humidity and the deterioration of the medicine progresses. Further, some drugs are easily oxidatively decomposed and some emit a specific odor. Therefore, there is a demand for absorbing gas such as oxygen and odor in the blister pack.

On the other hand, Patent Document 1 discloses a laminate for a blister pack, which includes an absorbent layer containing an absorbent in two auxiliary adsorption layers (skin layers) sandwiching the main adsorption layer, and a barrier layer. Here, first, a dome-shaped pocket portion is formed in the laminated body of the barrier layer and the adsorption layer. Then, a medicine, which is a tablet, is put in the pocket portion and is sealed with a lid material. According to this technique, it is considered that the dry state can be maintained, the oxidation can be prevented, and the odor can be efficiently removed without enclosing the desiccant or the like in the outer bag.

JP, 2006-334819, A

Patent Document 1 discloses that polypropylene or the like can be used as a barrier layer (base material). However, as a result of studies by the present inventors, when a pocket is formed by hot forming using an unstretched polypropylene film as a base material layer, a forming defect may occur.

Therefore, the present invention provides a laminate for a blister pack in which molding defects are less likely to occur even when an unstretched polypropylene film is used as a substrate, a blister pack using the same, and a blister pack package. The purpose is to

The present inventors have found that the above problems can be solved by the following means.
<<Mode 1>>
A laminate for a blister pack having a base film, an extruded resin layer, and an absorbent film in this order,
The substrate film includes an unstretched polypropylene film,
The extruded resin layer contains a polyolefin resin,
The absorbent film has an outer skin layer, an absorbent layer, and an inner skin layer,
The absorbent layer contains a polyethylene resin and an absorbent,
The outer skin layer and the inner skin layer each contain 15 wt% or more and less than 80 wt% polyethylene-based resin and more than 20 wt% and 85 wt% or less polypropylene-based resin, and 5 wt% of block polypropylene. A laminate for a blister pack containing the above.
<<Mode 2>>
The laminate according to aspect 1, wherein the outer skin layer and the inner skin layer each include 5 wt% to 65 wt% block polypropylene and 5 wt% to 65 wt% random polypropylene.
<<Mode 3>>
The laminate according to aspect 1, wherein the outer skin layer and the inner skin layer each contain 25 wt% to 85 wt% of block polypropylene.
<<Mode 4>>
The laminate according to any one of aspects 1 to 3, wherein the polyethylene-based resin contained in the outer skin layer and the inner skin layer contains linear low-density polyethylene.
<<Mode 5>>
The laminate according to any one of aspects 1 to 4, wherein the polyethylene-based resin contained in the absorption layer contains low-density polyethylene.
<<Mode 6>>
The laminate according to any one of aspects 1 to 5, wherein the absorbent film is a multilayer blown film.
<<Mode 7>>
The laminate according to any one of aspects 1 to 6, which does not have an aluminum layer.
<<Mode 8>>
The base film includes an unstretched polypropylene film having a thickness of 50 μm to 300 μm,
The extruded resin layer is an extruded resin layer made of low-density polyethylene having a thickness of 10 μm to 50 μm,
The absorbent film has an inner skin layer having a thickness of 5 μm to 30 μm, an absorbent layer having a thickness of 10 μm to 100 μm, and an outer skin layer having a thickness of 5 μm to 30 μm,
The absorbent layer comprises at least 15% to 99% by weight low density polyethylene and 1% to 60% by weight zeolite;
The outer skin layer and the inner skin layer each include linear low-density polyethylene of 15% by weight or more and less than 80% by weight, and polypropylene resin of more than 20% by weight and 85% by weight or less, and the polypropylene resin Is a block polypropylene or a combination of block polypropylene and random polypropylene.
<<Aspect 9>>
A laminated body according to any one of aspects 1 to 8, and a lid member having a heat-sealing layer and a barrier layer, wherein a pocket portion is formed in the laminated body, and between the laminated body and the lid member. A blister pack in which the contents can be stored.
<<Mode 10>>
A blister pack package having the blister pack according to aspect 9, and the contents stored in the pocket portion.

It is a schematic diagram of a blister pack. It is a schematic diagram of the layer structure of the blister pack of the present invention.

<<Laminate for blister pack>>
The blister pack laminate of the present invention has a base film, an extruded resin layer, and an absorbent film in this order. The substrate film used in the present invention includes an unstretched polypropylene film, the extruded resin layer includes a polyolefin resin, and the absorbent film has an outer skin layer, an absorbent layer, and an inner skin layer. The absorbent layer contains a polyethylene resin and an absorbent, and the outer skin layer and the inner skin layer each have a polyethylene resin content of 15% by weight or more and less than 80% by weight and a polypropylene resin content of more than 20% by weight and 85% by weight or less. It contains a resin and contains 5% by weight or more of block polypropylene.

An outer skin layer, an absorbent layer, and an absorbent film having an inner skin layer, and a blister pack laminate in which a substrate film is adhered with an extruded resin layer, in the case of using an unstretched polypropylene film as a substrate, During hot forming when forming the pocket portion, the absorption film may be melted due to the high forming temperature. On the other hand, in order to improve the heat resistance of the absorbent film, when polypropylene-based resin is used for each layer of the absorbent film, it becomes difficult to mold the absorbent film itself or the adhesion between the extruded resin layer and the absorbent film. In some cases, the strength was reduced and delamination occurred when molding the pocket portion.

On the other hand, the present inventors have used a polyethylene-based resin and a polypropylene-based resin in combination for the outer skin layer and the inner skin layer of the absorbent film, and include block polypropylene as a polypropylene-based resin in a specific amount or more, and By including a polyolefin-based resin in the extruded resin layer and the absorbent layer, even when an unstretched polypropylene film is used as a substrate, the above-mentioned molding defects are less likely to occur, and the molding of the absorbent film itself is also compared. It has been found that the adhesion strength of each layer is good. Without being bound by theory, this is because block polypropylene can impart heat resistance and flexibility to the absorbent film, and has relatively good compatibility with the polyethylene-based resin. It is considered that this is because the interlayer adhesion strength can be provided.

With reference to FIG. 1, a blister pack laminate B of the present invention has an outermost substrate film 10, an extruded resin layer 20, and an absorbent film 30 in this order, and is composed of these layers. .. A pocket portion is formed in the blister pack laminate B, the contents 100 are accommodated therein, and the blister pack package A is sealed with the lid member 40.

Referring to FIG. 2, in the laminated body B for a blister pack of the present invention, the absorbent film 30 is composed of an outer skin layer 31, an absorbent layer 32, and an inner skin layer 33, and the inner skin layer 33 is a lid member. The heat-sealing layer 41 of 40 is heat-sealed and bonded. The lid member 40 further includes at least a barrier layer 42.

The thickness of the laminate of the present invention is, for example, 500 μm or less, 400 μm or less, 300 μm or less, 250 μm or less, from the viewpoint of strength of the laminate, stiffness, push-through property when molded into a blister pack package, barrier properties, and the like. It can be 200 μm or less, 150 μm or less, or 100 μm or less, and can be 80 μm or more, 100 μm, 150 μm or more, or 200 μm or more. For example, the thickness of the laminate of the present invention can be 80 μm or more and 500 μm or less, or 150 μm or more and 400 μm or less.

<Base film>
The substrate film used in the laminate of the present invention includes a non-stretched polypropylene film, and may be composed of a non-stretched polypropylene film. The base film can be an outermost layer in the laminate of the present invention by isolating the absorbent film from the external environment and giving appropriate stiffness, strength and the like to the entire laminate.

The base film used in the laminate of the present invention becomes a laminate for an aluminum blister pack by including a base layer, an aluminum layer, and an optional reinforcing layer, which are known in the art, in this order. Although it may be used, it is preferably composed of an unstretched polypropylene film without including an aluminum layer.

In the present specification, "composed of A layer and B layer" and "composed of A layer" essentially mean a laminate including only A layer and B layer, and only A layer. However, it means that, in addition to the layer, other layers may be included within the range in which the advantageous effects of the present invention are obtained or the range in which the advantageous effects are not lost. .. For example, even if the anchor coat layer or the like is formed on the A layer, it may be expressed as “composed of the A layer”.

The thickness of the base film can be, for example, 400 μm or less, or 300 μm or less from the viewpoint of maintaining the barrier property and giving strength to the entire laminate of the present invention, and also 50 μm or more, 100 μm, 150 μm or more. , 180 μm or more, or 200 μm or more. For example, the thickness of the base film can be 50 μm or more and 400 μm or less, or 180 μm or more and 300 μm or less.

<Extruded resin layer>
The extruded resin layer contains a polyolefin resin in order to adhere the base film and the absorbent film and to increase the interlayer adhesion strength between the absorbent film and the outer skin layer. Examples of the polyolefin resin include polyethylene resin and polypropylene resin.

In the present specification, the term “polyethylene resin” means a repeating unit of an ethylene group in the main chain of the polymer, 30 mol% or more, 40 mol% or more, 50 mol% or more, 60 mol% or more, 70 mol% or more or 80 mol% or more Resins containing, for example, low density polyethylene (LDPE), linear low density polyethylene (LLDPE), medium density polyethylene (MDPE), high density polyethylene (HDPE), ethylene-acrylic acid copolymer (EAA), ethylene -Methacrylic acid copolymer (EMAA), ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate copolymer (EMA), ethylene vinyl acetate copolymer (EVA), carboxylic acid modified polyethylene, carboxylic acid modified It is selected from the group consisting of ethylene vinyl acetate copolymers, their derivatives, and mixtures thereof.

Among these, particularly in the extruded resin layer of the laminate of the present invention, LDPE, LLDPE, MDPE, EMMA, EAA, EMA and the like can be mentioned, and LDPE and/or LLDPE are particularly preferable. The extruded resin layer may contain another type of thermoplastic resin (for example, another type of polyolefin-based resin) as long as the advantageous effects of the present invention are not impaired.

The extruded resin layer can be formed between the absorbent film and the substrate film by sand laminating by extruding a molten resin to be the extruded resin layer and adhering them. The thickness of the extruded resin layer can be 10 μm or more, 15 μm or more, 20 μm or more, 25 μm or more, or 30 μm or more, and can be 60 μm or less, 40 μm or less, 30 μm or less, or 25 μm or less. For example, the thickness of the extruded resin layer can be 10 μm or more and 60 μm or less, or 15 μm or more and 40 μm or less.

<Absorption film>
The absorbent film used in the laminate of the present invention has an outer skin layer, an absorbent layer, and an inner skin layer, which are located on the base film side, in this order. The inner skin layer may have a heat-sealing property with the lid material, and the inner skin layer may form the outermost layer of the blister pack laminate on the side opposite to the base film or the base layer. it can.

The thickness of the absorbent film is, for example, 200 μm or less, 150 μm or less, 120 μm or less, or 100 μm or less, and 30 μm or more, 50 μm, or 70 μm or more. For example, the thickness of the absorbent film can be 30 μm or more and 200 μm or less, or 50 μm or more and 150 μm or less.

<Absorption film-absorption layer>
The absorbent layer contains an absorbent and a polyethylene resin, and contains the absorbent, so that it can absorb at least one of liquid and gas. Examples of the absorption target include water, odor components of drugs, and the like.

When the absorbent layer contains the polyethylene resin and the outer skin layer and the inner skin layer contain the polyethylene resin, the interlayer adhesion strength between these layers can be increased. Examples of the polyethylene-based resin used in the absorption layer include LDPE, LLDPE, EMAA, etc., and LDPE and/or LLDPE are particularly preferable. For example, in the absorbent layer, LDPE and LLDPE can be used in combination in accordance with the structure of the skin layer to improve the interlayer adhesion between them. In this case, the content of LDPE in the total weight of LDPE and LLDPE may be 10% by weight or more, 30% by weight or more, 50% by weight or more, 70% by weight or more, or 90% by weight or more, It may be 90 wt% or less, 70 wt% or less, 50 wt% or less, or 30 wt% or less.

The absorbent layer may contain 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, 50% by weight or more, or 60% by weight or more of a polyethylene resin, and 99% by weight or less, The content may be 95 wt% or less, 90 wt% or less, 80 wt% or less, 70 wt% or less, or 60 wt% or less. For example, the content of the polyethylene-based resin in the absorption layer can be 10% by weight or more and 90% by weight or less, or 30% by weight or more and 80% by weight or less.

The absorbent layer may contain another type of thermoplastic resin (for example, another type of polyolefin resin), for example, a polypropylene resin, as long as the advantageous effects of the present invention are not impaired. The absorbing layer may contain, as another type of thermoplastic resin, a polypropylene resin such as block PP, random PP or homo PP, the content of which is 10% by weight or more, 20% by weight or more, 30% by weight or more. %, 40% by weight, 50% by weight or more, or 60% by weight or more, and 80% by weight or less, 70% by weight or less, or 60% by weight or less.

Examples of the absorbent include inorganic absorbents. For example, as the inorganic absorbent, calcium oxide, calcium chloride, calcium sulfate, magnesium sulfate, sodium sulfate, calcium carbonate, magnesium oxide, barium oxide, diphosphorus pentoxide, magnesium perchlorate, potassium permanganate, permanganate. Examples thereof include chemical adsorbents such as sodium, quick lime and sodium thiosulfate, and physical adsorbents such as aluminum oxide, magnesium silicate, silica gel and inorganic molecular sieves. Examples of inorganic molecular sieves include, but are not limited to, aluminosilicate minerals, clay, porous glass, microporous activated carbon, zeolite, activated carbon, or compounds with an open structure capable of diffusing small molecules such as water. These can be mentioned and these can be used individually or in combination of two or more.

Of these, zeolite is particularly preferable as the inorganic absorbent. As the zeolite, natural zeolite, artificial zeolite, and synthetic zeolite can be used. As an example of the synthetic zeolite, there is Molecular Sieve (Union Showa Co., Ltd.), and among them, the pore (absorption port) diameter is 0.3 nm. Molecular sieves of ~1 nm can be used.

The average particle size of the inorganic absorbent (particle size at an integrated value of 50% in the particle size distribution obtained by the laser diffraction/scattering method) is not particularly limited, but for example, the volume-based median size (d50) is 10 nm or more. , 100 nm or more, 500 nm or more, 1 μm or more, 5 μm or more, or 10 μm or more, or 100 μm or less, 50 μm or less, 30 μm or less, 10 μm or less, 1 μm or less, or 200 nm or less. For example, the average particle diameter of the inorganic absorbent may be 5 μm or more and 100 μm or less in the micron order, or may be 10 nm or more and 200 nm or less in the nano order.

From the viewpoint of absorption capacity, the inorganic absorbent is 1% by weight or more, 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or It may be contained in the absorbent layer in an amount of 50% by weight or more, and from the viewpoint of dispersibility in polyethylene resin and moldability, 90% by weight or less, 80% by weight or less, 70% by weight or less, or 60% by weight or less. It can be contained in the absorption layer in the range of.

The thickness of the absorption layer may be 10 μm or more, 30 μm or more, 50 μm or more, 70 μm or more, or 90 μm or more, and may be 200 μm or less, 150 μm or less, 100 μm or less, or 80 μm or less. For example, the thickness of the absorption layer can be 30 μm or more and 200 μm or less, or 50 μm or more and 100 μm or less.

<Absorption film-skin layer>
The outer skin layer and the inner skin layer each contain a polyethylene resin of 15% by weight or more and less than 80% by weight and a polypropylene resin of more than 20% by weight and 85% by weight or less, and contain 5% by weight or more of block polypropylene. ..

By including these resins in the outer skin layer and the inner skin layer, high adhesiveness can be given between the absorbent layer and the polyolefin resin of the extruded resin layer, and the interlayer adhesion strength between them can be improved. You can Further, by providing a polypropylene resin to the outer skin layer and the inner skin layer, heat resistance can be imparted to these layers. Furthermore, since at least a part of the polypropylene-based resin is block polypropylene, it is possible to give the absorbent film flexibility in addition to heat resistance, thereby forming pockets in the blister pack laminate at a relatively high temperature. It was also found that molding defects are less likely to occur. Then, it was found that when the block polypropylene was used, higher heat resistance and interlayer adhesion strength could be imparted to the laminate than when other polypropylenes were used.

In the present specification, the polypropylene-based resin is a resin containing a repeating unit of a propylene group in the main chain of a polymer, which is 30 mol% or more, 40 mol% or more, 50 mol% or more, 60 mol% or more, 70 mol% or more, or 80 mol% or more. Examples include polypropylene (homo PP) homopolymer, random polypropylene (random PP), block polypropylene (block PP), chlorinated polypropylene, carboxylic acid modified polypropylene, and derivatives thereof, and mixtures thereof.

Here, homo PP is polypropylene that is substantially entirely composed of propylene units.

Random PP is a random copolymer of propylene as a main component and ethylene and/or an α-olefin having 4 or more carbon atoms as an addition component, and for example, 90 to 98% by mass of propylene and ethylene and/or carbon. It is a random copolymer with 10 to 2% by mass of α-olefin of 4 or more. The random polypropylene is preferably a random copolymer of 95 to 98% by mass of propylene and 5 to 2% by mass of ethylene and/or α-olefin having 4 or more carbon atoms.

The block PP is a resin having a sea-island structure in which polyethylene and/or an α-olefin polymer having a carbon number of 4 or more is dispersed in homopolypropylene, and polyethylene present in an island shape and/or a carbon number of 4 or more is present. An EPR phase (rubber phase) exists around the α-olefin polymer.

Examples of the polyethylene-based resin contained in the outer skin layer and the inner skin layer include LDPE, LLDPE, MDPE, etc., and LDPE and/or LLDPE are particularly preferable.

The content of the polyethylene resin contained in the outer skin layer and the inner skin layer is 15% by weight or more and less than 80% by weight. This content may be 20% by weight or more, 30% by weight or more, 40% by weight or more, 50% by weight or more, 60% by weight or more, or 70% by weight or more, and 75% by weight or less, 70% by weight or less. , 60 wt% or less, 50 wt% or less, 40 wt% or less, or 30 wt% or less. For example, the content of the polyethylene resin contained in the outer skin layer and the inner skin layer is 30% by weight or more and 70% by weight or less, or 40% by weight or more and 60% by weight or less.

Examples of polypropylene resins other than the block PP contained in the outer skin layer and the inner skin layer include homo PP and random PP.

The content of the polypropylene resin contained in the outer skin layer and the inner skin layer is more than 20% by weight and 85% by weight or less. The content may be 25% by weight or more, 30% by weight or more, 40% by weight or more, 50% by weight or more, 60% by weight or more, or 70% by weight or more, and 80% by weight or less, 70% by weight or less. , 60 wt% or less, 50 wt% or less, 40 wt% or less, or 30 wt% or less. For example, the content of the polypropylene resin contained in the outer skin layer and the inner skin layer is 30% by weight or more and 70% by weight or less, or 40% by weight or more and 60% by weight or less.

The content of the block PP contained in the outer skin layer and the inner skin layer is 5% by weight or more and 85% by weight or less. The content may be 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, 50% by weight or more, or 60% by weight or more, and 80% by weight or less, 70% by weight or less. , 60 wt% or less, 50 wt% or less, 40 wt% or less, 30 wt% or less, or 20 wt% or less. For example, the content of the block PP contained in the outer skin layer and the inner skin layer is 10% by weight or more and 70% by weight or less, 20% by weight or more and 60% by weight or less, or 30% by weight or more and 50% by weight or less.

The polypropylene resin of the outer skin layer and the inner skin layer may all be the block PP or may contain a polypropylene resin other than the block PP. When the outer skin layer and the inner skin layer contain a polypropylene resin other than the block PP, the content thereof is 70% by weight or less, and for example, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight. % Or more, 50% by weight or more, or 60% by weight or more, 70% by weight or less, 60% by weight or less, 50% by weight or less, 40% by weight or less, 30% by weight or less, 20% by weight or less, or It may be 10% by weight or less. For example, the content of the polypropylene resin other than the block PP contained in the outer skin layer and the inner skin layer is 10% by weight or more and 60% by weight or less, or 20% by weight or more and 50% by weight or less.

The outer skin layer and the inner skin layer may contain an absorbent as contained in the absorbent layer, in which case the absorbent may be contained in a content lower than that in the absorbent layer. However, it is preferable that the outer skin layer and the inner skin layer do not substantially contain an absorbent, and the content of the absorbent in each layer is 10% by weight or less, 5% by weight or less, or 3% by weight or less. Preferably.

The thickness of the outer skin layer and the inner skin layer may be 5 μm or more, 8 μm or more, 10 μm or more, or 20 μm or more, from the viewpoint of obtaining appropriate moldability and elasticity, 50 μm or less, 40 μm or less, 30 μm or less, or It may be 20 μm or less.

<Absorption film-molding method>
In order to form the absorbent film, the absorbent layer single layer is formed by inflation method, T-die method, calender method, casting method, press molding, extrusion molding or injection molding using at least an absorbent and a polyethylene resin. be able to. Then, an outer skin layer and an inner skin layer can be laminated.

Preferably, the absorbent film of the present invention including the outer skin layer, the absorbent layer and the inner skin layer can be produced by the multilayer inflation method. This is a method for producing a multilayer film by simultaneously extruding a plurality of resins into a tubular shape by a plurality of extruders and sending air into the resin to expand the resin. In this way, the absorbent layer and the skin layer can be coextruded and molded to obtain an absorbent film.

By the inflation method, before producing the absorbent film, preferably after kneading the absorbent and the polyethylene-based resin at least with a biaxial kneader, by processing into a pellet, the resin composition for the absorbent layer (pellet ) Is produced. Furthermore, the content of the inorganic absorbent may be adjusted by dilution by dry blending the above pellets with another resin pellet. Then, the absorbent film is manufactured by performing multilayer film formation by the multilayer inflation method using the pellets for the absorbent layer and the resin pellets for the skin layer. After the absorption layer is manufactured by the inflation method, the separately manufactured skin layer may be laminated by thermocompression bonding or the like to obtain the absorption film.

Also in the case of producing the absorbent layer single layer by the T-die method, the film can be formed after preparing pellets containing at least the absorbent and the polyethylene resin in advance. At this time, a skin layer may be coextruded on one or both surfaces of the absorbent layer to obtain an absorbent film including the absorbent layer and the skin layer.

The absorption layer and the skin layer are formed into a film or sheet by inflation method, T-die method, calender method, casting method, press molding, extrusion molding or injection molding, and they are laminated by a known method. By doing so, an absorbent film may be obtained.

<Other>
The laminate for a blister pack of the present invention further has, in addition to the above layers, a print layer, an anchor coat layer for enhancing adhesion between the two layers, a primer layer, etc. between any two layers. Good.

<<Blister pack and blister pack package>>
A blister pack of the present invention has the above blister pack laminate and a lid member. The blister pack laminate and the lid member are at least partially bonded. In the blister pack laminate, after molding the pocket portion for storing the contents such as tablets, the drug was stored in the pocket portion, the lid material was adhered, and the contents were stored in the pocket portion of the blister pack. Blister pack packages can be made.

<Contents>
The content of the blister pack of the present invention is not limited as long as it can be deteriorated by contact with the outside air, and examples thereof include foods, cosmetics, medical devices, electronic parts and the like in addition to drugs. In addition to pharmaceutical preparations, the drugs include detergents, agricultural chemicals and the like.

<Lid>
The lid member includes a heat seal layer and a barrier layer. As the heat seal layer, a well-known heat seal resin can be used, and preferably a polyolefin resin such as a polyethylene resin and a polypropylene resin can be used. The heat sealing layer of the lid member and the layer that is bonded to the lid member of the blister pack laminate can be appropriately selected from each other's resin from the viewpoint of enhancing the adhesiveness.

The barrier layer of the lid material may be, for example, an aluminum layer.

The lid material may be a form in which an aluminum foil is coated with an easy peeling resin such as a polyolefin-based polymer alloy, or a form in which an easy peeling film is laminated. In this case, the contents can be easily taken out by peeling the blister pack and the lid material at the adhesive interface.

<<Preparation of blister pack>>
<Examples 1 to 20 and Comparative Examples 1 to 7>
The laminates of Examples 1 to 20 and Comparative Examples 1 to 7 shown in Table 1 were produced as follows.

Pellets containing 20% by weight of zeolite and 80% by weight of low density polyethylene (hereinafter referred to as "LDPE") were prepared and used for forming the absorbent layer.

As the resin for the inner skin layer and the outer skin layer, pellets of the resin of each example shown in Table 1 were prepared, and these pellets were used together with the pellets for the absorption layer described above, and the absorption used in each example by the multilayer inflation method. A film was formed.

In the production of the absorbent films, the thickness of the inner skin layer and the outer skin layer was 10 μm, and the thickness of the absorbent layer was 60 μm in all examples. In addition, the resin composition of the inner skin layer and the outer skin layer is the same, and "Evolue SP2520" of Prime Polymer Co., Ltd. is used as linear low-density polyethylene (hereinafter referred to as "LLDPE"); block polypropylene ( Hereinafter, "Novatech BC6DRF" of Japan Polypro Co., Ltd. is used as "block PP"; "Wintech WFW5T" of Japan Polypro Co., Ltd. is used as random polypropylene (hereinafter, "random PP") did.

An unstretched polypropylene film having a thickness of 250 μm (Mitsubishi Chemical Corporation, Super Foil) is prepared as a base film, and the base film and the absorption film are LDPE (Suntech-LD L1850K, using a sand laminator). (Asahi Kasei Chemicals Corporation) was extruded to form a 30 μm extruded resin layer to obtain a laminate. Before adhering these, a two-component urethane anchor coating agent was applied to the base film side.

<Examples 21 to 25>
The absorbent films of Examples 21 to 25 were molded using the amount of zeolite shown in Table 2 and the amount and type of resin pellets shown in Table 2. At the time of molding the absorbent layer, other resin pellets were dry blended with the absorbent layer pellets used in Example 1 and the like. Using these absorbing films, a laminate was obtained in the same manner as in Example 1 and the like. The product numbers of the resins used in the absorbent films of Examples 21 to 25 are the same as those of the resins used in the absorbent films of Example 1 and the like.

"Evaluation method"
<Heat-resistant>
A 25 mm square sample was sandwiched on a hot plate of 130° C. above and 145° C. below with the substrate film side down and heated for 1 second, and the change in appearance was visually confirmed. The case where there was no change was evaluated as “◯”, the case where unevenness was generated on the surface was evaluated as “Δ”, and the case where the surface was melted and the substrate was deformed was evaluated as “x”.

<Interlayer adhesion>
The interlayer adhesion strength between the inner and outer skin layers and the absorption layer and between the outer skin layer and the extruded resin layer was measured by a tensile tester (Toyo Seiki Seisakusho, Strograph) in accordance with JIS Z1707. It was measured using. When the interlayer strength is 3 N/mm ² or more or when it cannot be measured due to adhesion, it is “◯”, when 1 N/mm ² or more and less than 3 N/mm ² , “Δ”, and when it is less than 1 N/mm ² , “ It was evaluated as "X".

<transparency>
The transparency was visually confirmed. When the laminated body of each example is placed on the paper on which the letters are written, it is "○" when the letters are highly transparent and clearly readable, "△" when the letters can be read, and when the letters cannot be read. It was evaluated as "x".

<Pocket formability>
Using a blister molding machine, pocket molding was performed by heating at a preset temperature of 140°C for 1 minute. After visually confirming the appearance after molding, it was impossible to mold because there was no peeling between layers or surface melt-out, and pocket molding was possible, ``○'', peeling between layers or surface melt-out. The case was evaluated as “x”.

"result"
The results are shown in Tables 1 and 2 below. The odor absorption capacity of the zeolite contained in the absorption layer was also confirmed, but it was confirmed that all the examples have absorption capacity.

Referring to these results, it can be seen that when LLDPE is too much, heat resistance tends to be low, and when polypropylene is too much, interlayer adhesion tends to be lowered. In addition, referring to Comparative Examples 5 to 7 in which only random PP is used among polypropylene, it is found that the heat resistance and the interlayer adhesion strength are very low. However, it was found that even in the case where random PP was used, heat resistance and interlayer adhesion strength could be improved by including a small amount of block PP. It is considered that this is because the block PP has better compatibility and/or dispersibility with the polyethylene resin than the random PP. On the other hand, when the number of blocks PP is large, the transparency tends to decrease.

With reference to Examples 22 to 24, it can be seen that good results are obtained even when the absorbing layer contains PP. Further, referring to Examples 21 and 25, it is found that good results are obtained even when the absorbing layer contains a large amount of LLDPE.

10 Base Film 20 Extruded Resin Layer 30 Absorbing Film 31 Outer Skin Layer 32 Absorbing Layer 33 Inner Skin Layer 40 Lid 41 Heat Seal Layer 42 Barrier Layer 100 Contents A Blister Pack Package B Blister Pack Laminate

Claims (10)

A laminate for a blister pack having a base film, an extruded resin layer, and an absorbent film in this order,
The substrate film includes an unstretched polypropylene film,
The extruded resin layer contains a polyolefin resin,
The absorbent film has an outer skin layer, an absorbent layer, and an inner skin layer,
The absorbent layer contains a polyethylene resin and an absorbent,
The outer skin layer and the inner skin layer each contain 15% by weight or more and less than 80% by weight of a polyethylene resin, and more than 20% by weight and 85% by weight or less of a polypropylene resin, and 5% by weight of block polypropylene. A laminate for a blister pack containing the above. The laminate according to claim 1, wherein the outer skin layer and the inner skin layer each include 5 wt% to 65 wt% block polypropylene and 5 wt% to 65 wt% random polypropylene. The laminate according to claim 1, wherein the outer skin layer and the inner skin layer each contain 25 wt% to 85 wt% of block polypropylene. The laminate according to any one of claims 1 to 3, wherein the polyethylene-based resin contained in the outer skin layer and the inner skin layer contains linear low-density polyethylene. The laminated body according to any one of claims 1 to 4, wherein the polyethylene-based resin contained in the absorption layer contains low-density polyethylene. The laminate according to any one of claims 1 to 5, wherein the absorbent film is a multilayer blown film. The layered product according to any one of claims 1 to 6 which does not have an aluminum layer. The base film includes an unstretched polypropylene film having a thickness of 50 μm to 300 μm,
The extruded resin layer is an extruded resin layer made of low density polyethylene having a thickness of 10 μm to 50 μm,
The absorbent film has an inner skin layer having a thickness of 5 μm to 30 μm, an absorbent layer having a thickness of 10 μm to 100 μm, and an outer skin layer having a thickness of 5 μm to 30 μm,
The absorbent layer comprises 15 wt% to 99 wt% low density polyethylene and 1 wt% to 60 wt% zeolite;
The outer skin layer and the inner skin layer each include linear low-density polyethylene of 15% by weight or more and less than 80% by weight, and polypropylene resin of more than 20% by weight and 85% by weight or less, and the polypropylene resin Is a block polypropylene or a combination of a block polypropylene and a random polypropylene, The laminate according to claim 1. It consists of the laminated body as described in any one of Claims 1-8, and the lid material which has a heat-sealing layer and a barrier layer, A pocket part is formed in the said laminated body, and the said laminated body and the said lid material. A blister pack that can store contents in between. A blister pack package having the blister pack according to claim 9 and contents stored in the pocket portion.

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