JP2019131469A - Pest control method, and agent composition for pest control and pest control agent set - Google Patents

Abstract

To provide a method capable of controlling various pests having no problem on safety at even low amount, an agent composition for pest control and a pest control agent set suitable for use in the method.SOLUTION: Pest is controlled by a method including applying 3-end-[2-propoxy-4-(trifluoromethyl)phenoxy]-9-[5-(trifluoromethyl)-2-pyridyloxy]-9-azabicyclo[3.3.1]nonane or a salt thereof together with 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[(methoxy amino)methylene]-2-methyl benzamide or a salt thereof to a target.SELECTED DRAWING: None

Description

  The present invention relates to a pest control method, a pest control pharmaceutical composition, and a pest control agent set. More specifically, the present invention relates to a method capable of controlling various pests with no safety problem and a low dosage, and a pest control pharmaceutical composition suitable for use in the method and a harmful composition. The present invention relates to a biocontrol agent set.

  Conventionally, many compounds having insecticidal / miticidal activity have been proposed. However, most of the proposed compounds have insufficient efficacy, their use is limited due to drug resistance problems, cause phytotoxicity and contamination of plants, and are toxic to livestock and fish. However, it was not always satisfactory. Under such circumstances, Patent Document 1 discloses that a cyclic amine compound having a specific structure has excellent insecticidal / miticidal activity. Patent Document 2 discloses that an isoxazoline-substituted benzamide compound having a specific structure is useful as an insecticide / acaricide.

WO 2011/078081 A1 WO 2007/026965 A1

  An object of the present invention is to provide a method capable of controlling various pests with no safety problem and a low dosage, and a pest control pharmaceutical composition and pest control suitable for use in the method. It is to provide a set of agents.

  As a result of intensive studies to solve the above problems, the present invention including the following modes has been completed.

That is, the present invention includes the following forms.
[1] 3-Endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane Or a salt thereof, 4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyamino) methylene] -2-methyl A pest control method comprising applying to a target object together with benzamide or a salt thereof.

[2] 3-Endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane Or a salt thereof and 4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyamino) methylene] -2-methyl A pharmaceutical composition for controlling pests, comprising benzamide or a salt thereof.

[3] 3-Endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane Or a pharmaceutical composition containing the salt thereof, and 4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyamino) A set of pest control agents that are combined together without mixing with a pharmaceutical composition containing methylene] -2-methylbenzamide or a salt thereof.

  According to the pest control method of the present invention, pests such as insects and mites can be controlled more safely with a smaller dose. The pest control pharmaceutical composition and the pest control agent set of the present invention can be suitably used in the pest control method of the present invention.

  The pest control method of the present invention includes applying Compound A together with Compound B to an object.

  Compound A is a compound of 3-endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1]. Nonane (hereinafter sometimes referred to as compound (I)) or a salt of compound (I). Compound (I) is a compound represented by formula (I) (CAS No .: 1332838-17-1). Compound (I) can be produced by the method described in Patent Document 1 and the like.

  The salt of compound (I) is not particularly limited as long as it is an agro-horticulturally acceptable salt. For example, salts of inorganic acids such as hydrochloric acid and sulfuric acid; salts of organic acids such as acetic acid and lactic acid; salts of alkali metals such as lithium, sodium and potassium; salts of alkaline earth metals such as calcium and magnesium; iron and copper And salts of organic metals such as ammonia, triethylamine, tributylamine, pyridine, hydrazine, and the like. The salt of compound (I) can be produced from compound (I) by a known method.

  Compound B is 4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyamino) methylene] -2-methylbenzamide (Hereinafter sometimes referred to as compound (II)) or a salt of compound (II). Compound (II) is a compound represented by formula (II) (CAS No .: 928783-29-3, general name: fluxametamide). Compound (II) can be produced by the method described in Patent Document 2 and the like.

  The salt of compound (II) is not particularly limited as long as it is an agro-horticulturally acceptable salt. For example, salts of inorganic acids such as hydrochloric acid and sulfuric acid; salts of organic acids such as acetic acid and lactic acid; salts of alkali metals such as lithium, sodium and potassium; salts of alkaline earth metals such as calcium and magnesium; iron and copper And salts of organic metals such as ammonia, triethylamine, tributylamine, pyridine, hydrazine, and the like. The salt of compound (II) can be produced from compound (II) by a known method.

  The mass ratio of compound A to compound B used in the method of the present invention (compound A / compound B) is not particularly limited, but is preferably 1,000 / 1 to 1/1000, more preferably 100/1 to 1. 1/100.

  In the method of the present invention, the active ingredient of Compound A or Compound B can be used as it is, however, a pharmaceutical composition containing Compound A, a pharmaceutical composition containing Compound B, or a pharmaceutical composition containing Compound A and Compound B. (Hereinafter, these three may be collectively referred to as a “pharmaceutical composition.” A pharmaceutical composition containing Compound A and Compound B may also be referred to as “a pest control pharmaceutical composition”.) It is preferable to use it. The pharmaceutical composition may be formulated into a known form. Possible forms of general agricultural chemicals or veterinary drugs by formulation, for example, wettable powder, granules, powders, tablets, emulsions, aqueous solvents, suspensions, wettable granules, flowable, microcapsules, aerosols, sprays Agent, spray agent, haze agent, heat transpiration agent, smoke agent, bait agent and the like. Moreover, what impregnated compound A and / or compound B to base materials, such as a porous ceramic board, a nonwoven fabric, and paper, may be used.

The amount of Compound A or Compound B or the total amount of Compound A and Compound B contained in the pharmaceutical composition varies slightly depending on the dosage form, but is usually 0.1 to 80% by mass with respect to the pharmaceutical composition. is there.
In dosage forms such as emulsions, solutions, wettable powders (eg, granular wettable powders), aqueous suspension formulations or microemulsions. The content of Compound A or Compound B or the total content of Compound A and Compound B is preferably 1 to 80% by mass, more preferably 10 to 50% by mass, based on the pharmaceutical composition.
In dosage forms such as oils and powders, the content of Compound A or Compound B or the total content of Compound A and Compound B is preferably 0.1 to 50% by mass, more preferably, relative to the pharmaceutical composition. It is about 0.1-20 mass%.
In dosage forms such as granules, tablets, jumbo and the like, the content of Compound A or Compound B or the total content of Compound A and Compound B is preferably 0.5 to 50 mass relative to the pharmaceutical composition. %, More preferably 0.5 to 10% by mass.

  The pharmaceutical composition may contain various additives or carriers. The carrier can be appropriately selected from a solid carrier, a liquid carrier, and a gas carrier according to the dosage form.

  Additives and carriers used in solid formulations include vegetable powders such as soybean flour, wheat flour, mineral fine powders such as diatomaceous earth, apatite, gypsum, talc, bentonite, pyrophyllite, clay, sodium benzoate, Examples thereof include organic and inorganic compounds such as urea and mirabilite.

  Solvents used in liquid formulations include kerosene, xylene and petroleum aromatic hydrocarbons, cyclohexane, cyclohexanone, dimethylformamide, dimethyl sulfoxide, alcohol, acetone, trichloroethylene, methyl isobutyl ketone, mineral oil, vegetable oil, water, etc. Can be mentioned.

  Examples of the gas carrier used in formulating the propellant include butane gas, LPG, dimethyl ether, carbon dioxide gas, and the like.

  Substrates for poisonous baits include food ingredients such as cereal flour, vegetable oil, sugar and crystalline cellulose; antioxidants such as dibutylhydroxytoluene and nordihydroguaiaretic acid; preservatives such as dehydroacetic acid; children such as pepper Anti-fouling agents by pets; pest-attracting perfumes such as cheese flavors and onion flavors.

  In order to take a uniform and stable form in the pharmaceutical composition, a surfactant can be added as necessary. The surfactant that can be added is not particularly limited. For example, alkyl phenyl ether added with polyoxyethylene, alkyl ether added with polyoxyethylene, higher fatty acid ester added with polyoxyethylene, sorbitan higher fatty acid ester added with polyoxyethylene, tristyryl added with polyoxyethylene Nonionic surfactants such as phenyl ether, sulfates of alkylphenyl ethers added with polyoxyethylene, alkylbenzene sulfonates, sulfates of higher alcohols, alkylnaphthalene sulfonates, polycarboxylates, lignin sulfones Acid salt, formaldehyde condensate of alkyl naphthalene sulfonate, and isobutylene-maleic anhydride copolymer.

  As long as the pharmaceutical composition does not impair the object of the present invention, it is used as necessary, bactericides, insecticides / acaricides, nematicides, plant regulators, synergists, fertilizers, soil improvers, animal It may contain feed.

  Specific examples of the insecticide / acaricide, nematicide, soil insecticide and anthelmintic are shown below.

(1) Acetylcholinesterase inhibitor:
(A) Carbamate series: Alanicarb, Aldicarb, Bengiocarb, Benfuracarb, Butcarboxyme, Butoxycarboxyme, Carbaryl, Carbofuran, Carbosulfuran, Ethiophenecarb, Fenobucarb, Formethanate, Furatiocarb, Isoprocarb, Methiocarb, Mesomil, Oxamyl, Pirimicarb, Propoxycarb Thiodicarb, thiophanox, triazamate, trimetacarb, XMC, xylylcarb; phenothiocarb, MIPC, MPMC, MTMC, aldoxicarb, alixicarb, aminocarb, bufencarb, cloetocarb, metam sodium, promecarb;

(B) Organophosphorus: Acephate, azamethiphos, azinephos-ethyl, azinephos-methyl, kazusafos, chlorethoxyphos, chlorfenvinphos, chlormefos, chlorpyrifos, chlorpyrifos-methyl, coumaphos, cyanophos, dimethone-S-methyl, diazinon, Dichlorvos / DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethione, etoprophos, famfur, phenamiphos, fenitrothion, fenthion, phostiazet, heptenophos, imisiaphos, isofenphos, isocarbophos, isoxathione, malathione, methalmethione, mecarbamethione Monocrotophos, nared, ometoate, oxydimethone-methyl, parathion, parathion-methyl, fento , Folate, hosalon, phosmet, phosphamidone, phoxime, pyrimiphos-methyl, propenophos, propetamphos, prothiophos, pyracrofos, pyridafenthion, quinalphos, sulfotep, tebupyrine phos, temefos, terbufos, tetrachlorbinphos, thiomethone, triazophos, trichlorfos, bamidthione; Bromophos ethyl, BRP, carbophenothione, cyanophenphos, CYAP, dimethone-S-methylsulfone, diariphos, diclofenthion, dioxabenzophos, etrimphos, phensulfothione, flupyrazophos, phonophos, formothione, phosmethylan, isazophos, iodofenphos, Methacrifos, pyrimifos-ethyl, phosphocarb, propaphos, protoate, sulprophos.

(2) GABA-agonist chloride channel antagonists: chlordane, endosulfan, ethiprole, fipronil, pyrafluprole, pyriprole; camfechlor, heptachlor, dienochlor.
(3) Sodium channel modulators: Acrinatrin, d-cis-trans allethrin, d-transarethrin, bifenthrin, bioareslin, bioareslin isomers, violesmethrin, cycloprotorin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda- Cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, ciphenothrin [(1R) -trans isomer], deltamethrin, enpentrin [(EZ)-( 1R) -isomers], esfenvalerate, etofenprox, fenpropatoline, fenvalerate, flucitrinate, flumethrin, tau-fulvalinate, halfenprox, imiprito , Cadreslin, permethrin, phenothrin [(1R) -trans isomer], praretrin, pyrethram, resmethrin, silafluophene, tefluthrin, tetramethrin, tetramethrin [(1R) -isomer], tralomethrin, transfluthrin; allethrin, pyrethrin, pyrethrin I, pyrethrin II, profluthrin, dimefluthrin, bioethanomethrin, biopermethrin, transpermethrin, fenfluthrin, fenpyritrin, fulbrocitrinate, flufenprox, methfluthrin, protofenbuto, pyrethmethrin, terraretrin.

(4) Nicotinic acetylcholine receptor agonists: acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam, sulfoxafurol, nicotine, flupiradiflon.
(5) Nicotinic acetylcholine receptor allosteric modulator: spinetoram, spinosad.
(6) Chloride channel activator: Abamectin, emamectin benzoate, lepimectin, milbemectin; ivermectin, selamectin, doramectin, eprinomectin, moxidectin, milbemycin, milbemycin oxime.
(7) Juvenile hormone-like substances: hydroprene, quinoprene, mesoprene, phenoxycarb, pyriproxyfen; geofenolan, epofenanane, triprene.
(8) Other non-specific inhibitors: methyl bromide, chloropicrin, sulfuryl fluoride, borax, and tartar.
(9) Homoptera selective feeding inhibitor: flonicamid, pymetrozine, pyrifluquinazone.

(10) Tick growth inhibitor: clofentezin, diflovidazine, hexythiazox, etoxazole.
(11) Microbial-derived insect midgut mesentery: Bacillus thuringiensis subsp. Isla elensis, Bacillus sphaericus, Bacillus thuringiensis subsp. Aisawai, Bacillus thuringiensis subsp. Kurstaki, Bacillus thuringiensis subsp. Tenebrionis, Bt Crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1 / Cry35Ab1.
(12) Mitochondrial ATP biosynthetic enzyme inhibitors: diafenthiuron, azocyclotin, cyhexatin, fenbutasine oxide, propargite, tetradiphone.
(13) Oxidative phosphorylation uncouplers: chlorfenapyr, sulframide, DNOC; binapacryl, dinobutone, dinocup.
(14) Nicotinic acetylcholine receptor channel blocker: bensultap, cartap hydrochloride; nereistoxin; thiosultap monosodium salt, thiocyclam.
(15) Chitin synthesis inhibitor: bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novallon, nobiflumuron, teflubenzuron, triflumuron, buprofezin, fluazuron.
(16) Diptera molting agent: cyromazine.
(17) Molting hormone receptor agonists: Chromafenozide, halofenozide, methoxyphenozide, tebufenozide.
(18) Octopamine receptor agonist: amitraz, demiditraz, chlordimeform.
(19) Mitochondrial electron transport system complex III inhibitor: acequinosyl, fluacrylpyrim, hydramethylnon.
(20) Mitochondrial electron transport complex I inhibitor: phenazaquin, fenproxymate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, rotenone.

(21) Voltage-gated sodium channel blocker: indoxacarb, metaflumizone.
(22) Acetyl CoA carboxylase inhibitor: spirodiclofen, spiromesifen, spirotetramat.
(23) Mitochondrial electron transport complex IV inhibitor: Aluminum phosphide, calcium phosphide, phosphine, zinc phosphide, cyanide.
(24) Mitochondrial electron transport system complex II inhibitor: Sienopyrafen, cyflumetofene, piflummid.
(25) Ryanodine receptor modulator: chlorantraniliprole, cyantraniprole, fulvendiamide, cyclaniliprol, tetraniprolol.
(26) Mixed function oxidase inhibitor compound: Piperonyl butoxide.
(27) Latrophilin receptor agonist: depsipeptide, cyclic depsipeptide, 24-membered cyclic depsipeptide, emodepside.
(28) Other agents (unknown mechanism of action): azadirachtin, benzoximate, biphenazate, bromopropyrate, quinomethionate, cryolite, dicofol, pyridalyl; bencrothiaz, sulfur, amidoflumet, 1,3-dichloropropene, DCIP , Phenisobromolate, benzomate, metaldehyde, chlorbenzilate, clothiazoben, dicyclanyl, phenoxacrime, fentriphanyl, flubenzimine, fluphenazine, gossip lure, japonyla, methoxadiazone, petroleum, potassium oleate, tetrasul, trialacene; afidopyropen), flometokin, flufiprole, fluenesulfone, meperfluthrin, tetramethylfluthrin, tralopyril, dimefluthrin, me Luneodecanamide; fluralanel, afoxolanel, floxamethamide, 5- [5- (3,5-dichlorophenyl) -5-trifluoromethyl-4,5-dihydroisoxazol-3-yl] -2- (1H-1,2, , 4-Triazol-1-yl) benzonitrile (CAS: 943137-49-3), brofuranilide and other metadiamides.

(29) Anthelmintic:
(A) benzimidazole series: fenbendazole, albendazole, triclabendazole, oxybendazole, mebendazole, oxfendazole, perbendazole, fulbendazole; fevantel, netobimine, thiophanate; thiabendazole, canbendazole;
(B) salicylanilide series: closantel, oxyclozanide, rafoxanide, niclosamide;
(C) substituted phenols: nitroxinyl, nitroskanate;
(D) Pyrimidine series: Pirantel, Morantel;
(E) imidazothiazole series: levamisole, tetramisol;
(F) Tetrahydropyrimidine series: praziquantel, epsiprantel;
(G) Other anthelmintic drugs: cyclodiene, riania, chlorthrone, metronidazole, demiditraz; piperazine, diethylcarbamazine, dichlorophene, monepantel, tribendimidine, amidantel; thiacetalsamide, melolsamine, arsenamide.

Specific examples of the disinfectant are shown below.
(1) Nucleic acid biosynthesis inhibitors:
(A) RNA polymerase I inhibitor: benalaxyl, benalaxyl-M, furaxyl, metalaxyl, metalaxyl-M; oxadixil; cloziracone, off-race;
(B) adenosine deaminase inhibitor: bupilimate, dimethylylmol, ethylimol;
(C) DNA / RNA synthesis inhibitors: Himexazole, octirinone;
(D) DNA topoisomerase II inhibitor: Oxophosphate.

(2) Mitotic fission inhibitor and cell division inhibitor:
(A) β-tubulin polymerization inhibitor: benomyl, carbendazim, chlorphenazole, fuberidazole, thiabendazole; thiophanate, thiophanate-methyl; dietofencarb; zoxamide; ethaboxam;
(B) Cell division inhibitor: Penciclone;
(C) Delocalization inhibitor of spectrin-like protein: fluopicolide.

(3) Respiratory inhibitor:
(A) Complex I NADH oxidoreductase inhibitor: diflumetrim; tolfenpyrad;
(B) Complex II succinate dehydrogenase inhibitors: benodanyl, flutolanil, mepronil; isofetamide; fluopyram; fenfram, flumecyclox; carboxin, oxycarboxyl; tifluzamide; , Furametopyr, isopyrazam, penflufen, penthiopyrad, sedaxane; boscalid;
(C) Complex III ubiquinol oxidase Qo inhibitor: azoxystrobin, cumoxystrobin, cumethoxystrobin, enoxastrobin, fluphenoxystrobin, picoxystrobin, pyroxystrobin; Piramethostrobin, triclopyricarb; Cresoxime-methyl, trifloxystrobin; Dimoxystrobin, Phenaminestrobin, Metominostrobin, Orisastrobin; Famoxadone; Fluoxastrobin; Fenamidon; Pyribencarb;
(D) Complex III ubiquinol reductase Qi inhibitor: cyazofamide; amisulbrom;
(E) Uncoupler of oxidative phosphorylation: Binapacryl, meptyldinocup, dinocup; fluazinam; ferrimzone;
(F) Oxidative phosphorylation inhibitor (inhibitor of ATP synthase): fentin acetate, fentin chloride, fentin hydroxide;
(G) ATP production inhibitor: silthiofam;
(H) Complex III: Cyclochrome Qx (unknown) inhibitor of bc1 (ubiquinone reductase): Amethoctrazine.

(4) Amino acid and protein synthesis inhibitors (a) Methionine biosynthesis inhibitors: Andoprim, cyprodinil, mepanipyrim, pyrimethanil;
(B) Protein synthesis inhibitor: blasticidin-S; kasugamycin, kasugamycin hydrochloride; streptomycin; oxytetracycline.

(5) Signaling inhibitor:
(A) Signaling inhibitor: quinoxyphene, proquinazide;
(B) MAP / histidine kinase inhibitor in osmotic signal transduction: fenpiclonil, fludioxonil; clozolimate, iprodione, procymidone, vinclozolin.

(6) Lipid and cell membrane synthesis inhibitors:
(A) Phospholipid biosynthesis, methyltransferase-inhibitors: edifenphos, iprobenphos, pyrazophos; isoprothiolane;
(B) lipid peroxidants: biphenyl, chloroneb, dichlorane, kinden, technazene, tolcrofosmethyl; etridiazole;
(C) Agents that act on cell membranes: iodocarb, propamocarb, propamocarb hydrochloride, propamocarbfocetylate, prothiocarb;
(D) Microorganisms that disturb the cell membrane of pathogenic bacteria: Bacillus subtilis, Bacillus subtilis QST713 strain, Bacillus subtilis FZB24 strain, Bacillus subtilis MBI600 strain, Bacillus subtilis D747 strain;
(E) Agent that disturbs the cell membrane: An extract of Goseika Yupte (Tea Tree).

(7) Cell membrane sterol biosynthesis inhibitors:
(A) Demethylation inhibitor at C14 position in sterol biosynthesis: Triphorine; Pyrifenox, Pyriisoxazole; Phenarimol, Flurprimidol, Nuarimol; Imazalyl, Imazaryl Sulfate, Oxpoconazole, Pefrazoate, Prochloraz, Triflumizole, biniconazole;
Azaconazole, viteltanol, bromconazole, cyproconazole, diclobutrazole, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriazole), fluconazole, fluconazole- Cis, hexaconazole, imibenconazole, ipconazole, metconazole, microbutanyl, penconazole, propiconazole, quinconazole, cimeconazole, tebuconazole, tetraconazole, triadimethone, triadimenol, triticonazole; prothioconazole, voriconazole;
(B) Inhibitors of Δ14 reductase and Δ8 → Δ7-isomerase in sterol biosynthesis:
Aldimorph, dodemorph, dodemorph acetate, fenpropimorph, tridemorph; fenpropidin, piperalin; spiroxamine;
(C) 3-keto reductase inhibitor in C4-demethylation of sterol biosynthesis system: phenhexamide; fenpyrazamine;
(D) Sterol biosynthetic squalene epoxidase inhibitors: Pyributicarb; Naftifen, Terbinafine.

(8) Cell wall synthesis inhibition (a) Trehalase inhibitor: Validamycin;
(B) chitin synthase inhibitor: polyoxin, polyoxolim;
(C) Cellulose synthase inhibitor: dimethomorph, furmorph, pyrimorph; benavalicarb, iprovaricarb, toluprocarb, varifenalate; mandipropamide.

(9) Melanin biosynthesis inhibitor (a) Reductase inhibitor of melanin biosynthesis: Fusaride; Pyroxylone; Tricyclazole;
(B) Dehydrase inhibitor of melanin biosynthesis: carpropamide; diclocimet; phenoxanyl.

(10) Host plant resistance inducer:
(A) Agents acting on the salicylic acid synthesis pathway: Acibenzoral-S-methyl;
(B) Other: Probenazole; thiazinyl; isotianil; laminarin;

(11) Agents whose activity is unknown: Simoxanyl, fosetyl aluminum, phosphoric acid (phosphate), teclophthalam, triazoxide, fursulfamide, dichromedin, metasulfocarb, cyflufenamide, metolaphenone, pyriophenone, dodin, dodin free base, fluthianyl.

(12) Agents with multiple action points: copper (copper salt), Bordeaux liquid, copper hydroxide, copper naphthalate, copper oxide, copper oxychloride, copper sulfate, sulfur, sulfur products, calcium polysulfide; farbum, mancozeb, maneb) , Mankappa, methylam, polycarbamate, propineb, thiram, dineb, ziram; captan, captahol, phorpet; chlorothalonil; diclofluuride, tolylfluanid; guazatine, iminotadine acetate, iminoctadine albecate; anilazine; Quinomethionate; Fluorimide.

(13) Other agents: DBEDC, fluorophorpet, guazatine acetate, bis (8-quinolinolato) copper (II), propamidine, chloropicrin, ciprofuram, Agrobacterium, betoxazine, diphenylamine, methyl isothiocyanate (MITC ), Mildeomycin, Capsaicin, Cufraneb, Cyprosulfamide, Dazomet, Debacarb, Dichlorophen, Diphenzoquat, Diphenzoquat methylsulfonate, Flumetober, Focetyl calcium, Focetyl sodium, Irumamycin, Natamycin, Nitrotal isopropyl , Oxamocarb, sodium propamocin, pyrrolnitrin, tebufloquine, torniphanide, zaliramide, Algophase, amicarthiazole (Amicarthiazol), oxathia Piperoline (Oxathiapiprolin), methylam zinc, benazole, trichramide, uniconazole, mildeomycin, oxyfentiin (Oxyfenthiin), picarbutrazox (picarbutrazox).

Specific examples of plant regulators are shown below.
Abscisic acid, kinetin, benzylaminopurine, 1,3-diphenylurea, forchlorfenuron, thidiazuron, chlorfenuron, dihydrozeatin, gibberellin A, gibberellin A4, gibberellin A7, gibberellin A3, 1-methylcyclopropane, N-acetyl Aminoethoxyvinylglycine (also known as abiglycine), aminooxyacetic acid, silver nitrate, cobalt chloride, IAA, 4-CPA, cloprop, 2,4-D, MCPB, indole-3-butyric acid, dichloroprop, phenothiol, 1 -Naphtylacetamide, Ethiclozate, Cloxiphonac, Maleic acid hydrazide, 2,3,5-Triiodobenzoic acid, Salicylic acid, Methyl salicylate, (-)-Jasmonic acid, Methyl jasmonate, (+)-Strigol, (+) -Deoxyst Goal, (+) - Orobankoru, (+) - Sorugorakuton, 4-oxo-4- (2-phenylethyl) amino acid; ethephon, chlormequat, mepiquat chloride, benzyl adenine, 5-aminolevulinic acid.

  As an embodiment of the method of the present invention, for example, a pharmaceutical composition containing Compound A and a pharmaceutical composition containing Compound B are prepared, respectively, and they are placed on the object at the same time or before and after opening little time. Applying; preparing a pharmaceutical composition containing Compound A and a pharmaceutical composition containing Compound B, mixing them, and applying the resulting mixture to an object; Compound A and Compound B Preparation of a pharmaceutical composition containing, and applying it to an object.

The pest control agent set of the present invention is a combination of a pharmaceutical composition containing Compound A and a pharmaceutical composition containing Compound B, without mixing them. The pest control agent set of the present invention makes it easy to obtain a ratio of compound A and compound B suitable for controlling the target pest, and contains a pharmaceutical composition containing compound A and compound B. It is possible to save the trouble of preparing each of the pharmaceutical compositions separately. In the pest control agent set of the present invention, in addition to the pharmaceutical composition containing Compound A and the pharmaceutical composition containing Compound B, other agents suitable for controlling the target pest, for example, bactericides , Insecticide / acaricide, nematicide, plant regulator, synergist, fertilizer, soil improver, animal feed, etc. It is preferable that they are collected together. Furthermore, the pest control agent set of the present invention may include a measuring cup or dropper, a mixing tank, a glove, a mask, or the like.
There are no particular restrictions on the form of grouping. For example, each pharmaceutical composition can be separately stored in a bag, box, bottle, can, etc., and stored together in a container such as a bag or box.

  The pharmaceutical composition for controlling pests of the present invention contains Compound A and Compound B. In the pharmaceutical composition for controlling pests of the present invention, compound A and compound B are mixed at a predetermined ratio, so that the pharmaceutical composition containing compound A and the pharmaceutical composition containing compound B are measured, It is possible to save the trouble of mixing. The pharmaceutical composition for controlling pests of the present invention can be stored or transported by bagging, bottled, boxed, canned or the like depending on the dosage form.

  The method of the present invention is not particularly limited by the manner of application to the object. For example, wettable powders, emulsions, flowable powders, aqueous solvents and granular wettable powders can be applied by diluting with water to a prescribed concentration and spraying them on plants or soil as dissolved solutions, suspensions or emulsions. can do. Powders and granules can be applied by spreading on plants or soil. Formulations such as poison baits and mite-proof sheets can be applied by placing them in desired places or hanging them. Gas preparations such as aerosols and aerosols can be applied using a device such as a spray. Furthermore, it can be applied by known veterinary techniques (topical, oral, parenteral or subcutaneous administration). Veterinary methods include oral administration to animals by tablets, capsules, feed mixing, etc .; administration to animals by immersion, suppository, injection (intramuscular, subcutaneous, intravenous, intraperitoneal, etc.) A method in which an oily or aqueous solution is locally administered by spraying, pour-on, spot-on, etc .; an ectoparasite control agent is kneaded into the resin, and the kneaded product is formed into an appropriate shape such as a collar or ear tag; And the like, and is administered locally to an animal.

  The above-described fungicides, insecticides / acaricides, nematicides, plant regulators, synergists, fertilizers, soil conditioners, as described above, with or without application at the same time. Animal feed or the like may be applied to the object.

  The application amount to the target is not particularly limited, and can be appropriately set according to the type of control target, the control time, and the like. For example, in order to control mites parasitizing domestic animals such as cattle and pigs, and pet animals such as dogs and cats, for example, the total amount of Compound A and Compound B is 0 with respect to 1 kg of the host animal. It can be applied at a ratio of 0.01 to 1000 mg.

  Examples of objects to be applied include cereals; vegetables; root vegetables; potatoes; trees such as fruit trees, tea, coffee and cacao; pastures; turf; plants such as cotton. Plants as application objects are not limited by original species, varieties, improved varieties, cultivars, mutants, hybrids, genetically modified organisms (GMO), and the like. In the method of the present invention, it may be applied to the whole plant, or applied to a part of the plant such as leaves, stems, stems, flowers, persimmons, fruits, seeds, sprout, roots, tubers, tuberous roots, shoots and cuttings. May be. In order to control various agricultural pests and mites, seed treatment, foliage application, soil application, water application, and the like can be performed.

  In addition, the target of application can be a host animal of ectoparasites; pets such as dogs and cats; pets; livestock such as cattle, horses, pigs and sheep; warm-blooded animals such as poultry; Insects such as stag beetles and beetles can be mentioned.

  The pests that can be controlled by the method of the present invention are not particularly limited. Examples include sanitary pests, storage pests, clothing pests, house pests, parasites, and crop pests. The method of the present invention can be carried out at all stages of development of pests to be controlled. For example, the method of the present invention can be performed on eggs, nymphs, larvae, pupae and adults.

Examples of pests to be controlled are shown below.
(1) Lepidoptera butterfly or moth, for example
(1-a) Arctiidae moths such as Hyphantria cunea and Lemyra imparilis;
(1-b) buds of the family Bucculatricidae such as Bucculatrix pyrivorella;
(1-c) moths of Carposinidae such as Carposina sasakii;
(1-d) Diaphania spp., Such as cotton pear (Diaphania indica), Diaphania nitidalis; Ostrinia furnacalis; Ostrinia spp. such as scapulalis; and Chilo suppressalis, Cnaphalocrocis medinalis, Conogethes punctiferalis, Southwestern conborator (Diatraea grandiosella), ly pho des py Crambadae moths such as Hellula undalis, other genus species such as Parapediasia teterrella;
(1-e) moths of the eleganidae (Gelechiidae) such as Helcystogramma triannulella, cotton beetle (Pectinophora gossypiella), potato moth (Phthorimaea operculella), Sitotroga cerealella;
(1-f) Geometridae moths such as Ascotis selenaria;
(1-g) moths of the family Gracoillariidae such as Caloptilia theivora, citrus leafworm (Phyllocnistis citrella), and king-butterfly moth (Phyllonorycter ringoniella);
(1-h) Hesperiidae butterflies, for example Parsara guttata;
(1-i) Lasiocampidae moths, for example, Malososoma neustria;
(1-j) Lymantriidae moths, for example, Lymantria spp., Lymantria dispar, Nonmanai (Lymantria monacha); Other genus species, Euproctis pseudoconspersa, Hime Orgyia thyellina;

(1-k) moths of the family Lyonetiidae, for example, Lyonetia clerkella, Lyonetia prunifoliella malinella, from the genus Lyonetia spp .;
(1-l) Noctuidae moths, for example, Spodoptera spp., Spodoptera depravata, Southern army worm (Spodoptera eridania), Spodoptera exigua, Spodoptera exigua Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura; Autographa spp., Autographa gamma, Autographa nigrisigna; Agrotis sp. Agrotis sp. Agrotis ipsilon, Agrotis segetum; Helicoverpa spp., Helicoverpa armigera, Tobacco moth (Helicoverpa assulta), Cotton ball worm (Helicoverpa zea); Heliothis spp. , Cottontail (Heliothis armigera), fake American tobacco (Heliothis virescens); Aedia leucomelas, Ctenoplusia agnata, Eudocima tyrannus, Mamestra brassicae, Mythimna separata, Naranga aenescens, Paloma romap , Pseudoplusia includens, Trichoplusia ni;
(1-m) Nolidae moths, eg, Misaria olinga (Earias insulana);
(1-n) Pieridae butterflies, for example, Pieris brassicae, Pieris rapae crucivora from the genus Pieris spp .;
(1-o) Plutellidae moths, for example, Acrolepiopsis sapporensis, Acrolepiopsis suzukiella, Aclutepiopsis suzukiella; Plutella xylostella, from other genus species ;
(1-p) Pyralidae moths such as Cadra cautella, Elasmopalpus lignosellus, Etiella zinckenella, Galleria mellonella;
(1-q) Sphingidae moths, for example, Manduca quinquemaculata, Manduca sexta, Manduca spp.

(1-r) moths of the family Stahmopodidae, for example, Stahmopoda masinissa;
(1-s) moths from the family Tineidae, for example, tiger (Tinea translucens);
(1-t) Tortricidae moths, for example, Adoxophyes honmai, Adoxophyes orana of Adoxophyes spp .; for example, Archips spp.), from the other species, Choristoneura fumiferana, Cydia pomonella, Eupoecilia ambiguella (Eupoecilia ambiguella) Grapholitha molesta, Chamonaki (Homona magnanima), Leguminivora glycinivorella, Lobesia botrana, Matsumuraeses phaseoli, Pandemis heparana, Pandemis heparana
(1-u) Yponomeutidae moth, for example, Argyresthia conjugella.

(2) Thysanoptera pests (2-a) from the Phlaeothripidae, for example, Ponticulothrips diospyrosi;
(2-b) Thripidae, for example, Frankliniella intonsa, Frankliniella occidentalis; for example, Frankliniella occidentalis; for example, Thrips spp. Southern thrips (Thrips palmi), Thrips tabaci; Other species, Croton thrips (Heliothrips haemorrhoidalis), Scirtothrips dorsalis.

(3) Hemiptera pests (3-A) Ceratozodia (Archaeorrhyncha)
(3-Aa) From the Delphacidae family, for example, the green planthopper (Laodelphax striatella), the green planthopper (Nilaparvata lugens), the black planthopper (Perkinsiella saccharicida), and the white planthopper (Sogatella furcifera).

(3-B) Clypeorrhyncha
(3-Ba) From the family of Cicadellidae, for example, from the Empoasca spp., The Empoasca fabae, the Empoasca nipponica, the Empoasca onukii, the mackerel Empoasca sakaii; other genus species, Arboridia apicalis, Balclutha saltuella, Epiacanthus stramineus, Macrophteles striifrons, (Nephotettix cinctinceps).

(3-C) Stink bug (Heteroptera)
(3-Ca) of the family Alydidae, for example, Riptortus clavatus;
(3-Cb) from the family Coridae, for example, Cletus punctiger, Leptocorisa chinensis;
(3-Cc) from the family Lygaeidae, for example, the American leaf beetle (Blissus leucopterus), the leaf beetle (Cavelerius saccharivorus), the leaf beetle (Togo hemipterus);
(3-Cd) members of the family Miridae, for example, Black-headed turtle (Halticus insularis), Sabiiroka-sika turtle (Lygus lineolaris), Cotton-free hopper (Psuedatomoscelis seriatus), Nugget-headed turtle (Stenodema sibiricum) Stenotus rubrovittatus), Trigonotylus caelestialium;

(3-Ce) from the family Pentatomidae, for example, Nezara antennata, Nezara viridula, from the species of Nezara spp .; for example, Eysarcoris spp. ), Eysarcoris aeneus, Eysarcoris lewisi, Eysarcoris ventralis, other genus species such as Dolycoris baccarum, Eurydemarus ), Heryomorpha halys, Piezodorus hybneri, Plautia crossota, Scotinophora lurida;
(3-Cf) from the family Pyrrhocoridae, for example, Dysdercus cingulatus;
(3-Cg) from the family Rhopalidae, for example, Rhopalus msculatus;
(3-Ch) from the family Scutelleridae, for example, Eurygaster
integriceps);
(3-Ci) From the family Tingidae, for example, Stephanitis nashi.

(3-D) Sternorrhyncha
(3-Da) from the family Adelgidae, for example, Adelges laricis;
(3-Db) Whitefly family (Aleyrodidae) For example, Bemisia spp., Silver leaf whitefly (Bemisia argentifolii), Tobacco whitefly (Bemisia tabaci); Other genera species, Aleurocanthus spiniferus, Citrus whitefly (Dialeurodes citri), Onale whitefly (Trialeurodes vaporariorum);

(3-Dc) Aphididae, for example, Aphis spp., Bean aphids (Aphis craccivora), bean aphids (Aphis fabae), strawberry aphids (Aphis forbesi), cotton aphids (Aphis) gossypii), European apple aphids (Aphis pomi), elder-core aphids (Aphis sambuci), Aphis spiraecola; for example, Rhopalosiphum spp. E.g., Dysaphis plantaginea, Dysaphis radicola; eg, Macrosiphum spp., Macrosiphum avenae, Macrosiphum avenae, Macrosiphum euphorbiae; for example, from Myzus spp. Amycorus aphids (Myzus cerasi), Myzus persicae, Myzus varians; other genera, Acyrthosiphon pisum, potato aphid (Aulacorthum aphid) (Brachycaudus helichrysi), radish aphid (Brevicoryne brassicae), strawberry aphid (Chaetosiphon fragaefolii), peach beetle (Hyalopterus pruni), victoria aphid (ura) phi viciae), wheat aphid (Metopolophium dirhodum), lettuce aphid (Nasonovia ribis-nigri), hops aphid (Phorodonhumuli), barley aphid (Schizaphis graminum), wheat aphid (Sitobion avenae), Komikan Mussel (Toxoptera aurantii);

(3-Dd) from the family Coccidae, for example, Ceroplastes ceriferus, Ceroplastes rubens, of the genus Ceroplastes spp .;
(3-De) Pseudaulacaspis pentagona, Pseudaulacaspis prunicola of Pseudaulacaspis spp., For example, Unaspisp sp. .) Of the Aspergillus scale insect (Unaspis euonymi), Alaska scale insect (Unaspis yanonensis); Other species, Aonidiella aurantii; Scale insect (Pseudaonidia paeoniae);
(3-Df) from the order of the Margarodidae, for example, Drosicha corpulenta, Icerya purchasi;
(3-Dg) from the family Phylloxeridae, for example, grape aphids (Viteus vitifolii);
(3-Dh) from the family Pseudococcidae, for example, Planococcus spp., Planococcus citri, Planococcus kuraunhiae; (Phenacoccus solani), Pseudococcus comstocki;
(3-Di) From the family Psyllidae, for example, Psylla mali of Psylla spp., Psylla pyrisuga; Diaphorina citri of other genus species.

(4) Coleoptera pests (4-a) from the family Anobiidae, for example, the tobacco beetle (Lasioderma serricorne);
(4-b) from the Attelabidae family, for example, Byctiscus betulae, Rhynchites heros;
(4-c) from the family Bostrichidae, for example, Lyctus brunneus;
(4-d) from the family Brentidae, for example, Cylas formicarius;
(4-e) from the Buprestidae family, for example, Agrilus sinuatus;
(4-f) From the Cerambycidae family, for example, Anoplophora malasiaca, Monochamus alternatus, Psacothea hilaris, Xylotrechus pyrrhoder;
(4-g) from the family Chrysomelidae, for example, from the genus Bruchus spp., From the pea weevil (Bruchus pisorum), from the broad beetle (Bruchus rufimanus); for example from the genus Diabrotica spp. Northern corn root worm (Diabrotica barberi), Southern corn root worm (Diabrotica undecimpunctata), Western corn root worm (Diabrotica virgifera); for example, Phyllotreta spp., Phyllotreta nemorum, Phyllotreta striolata); other genera of the genus, Aulacophora femoralis, Adzuki beetle (Callosobruchuschinensis), Tortoise beetle (Cassida nebulosa), Chestnut beetle (Chaetocnema concinna), Colorado potato beetle (Leptinotarsa decemlineata) ), Psylliodes angusticollis;

(4-h) from the Coccinellidae family, for example, Epilachna varivestis, Epilachna vigintioctopunctata, from the genus Epilachna spp .;
(4-i) Curculionidae, for example, Anthonomus grandis, Anthonomus pomorum of Anthonomus spp .; for example, Sitophilus spp. ), Sitophilus granarius, Sitophilus zeamais; Other genus species, Echinocnemus squameus, Euscepes postfasciatus, Hyanabium weevil (Hylobius abietis), Alfalfa era ), Rice weevil (Lissohoptrus oryzophilus), horned weevil (Otiorhynchus sulcatus), red weevil (Sitona lineatus), Sphenophorus venatus;
(4-j) from the Elateridae family, for example, Melanotus fortnumi, Melanonotus tamsuyensis, from the genus Melanotus spp .;
(4-k) from the family Nitidulidae, for example, Epuraea domina;
(4-l) From the family Scarabaeidae, for example, Anomala spp., Anomala cuprea, Anomala rufocuprea; Other genera, Cetonia aurata, Coreo Clams (Gametis jucunda), Heptophylla picea, Melonlontha melolontha, Popillia japonica;
(4-m) from the Scolytidae family, for example, Ips typographus;
(4-n) from the family Staphylinidae, for example, Paederusfuscipes;
(4-o) from the Tenebrionidae family, for example, Tenebrio molitor, Tribolium castaneum;
(4-p) from the Trogossitidae family, for example, Tenebroides mauritanicus.

(5) Flies (Diptera) pests (5-A) Flies (Brachycera)
(5-Aa) from the family Agromyzidae, for example, Liriomyza bryoniae, Liriomyza bryoniae, Liriomyza chinensis, Liriomyza sativae, Liriomyza sativae, Trifolia myr ); Other genus species, Chromatomyia horticola, Agromyza oryzae;
(5-Ab) from the family Anthomyiidae, for example, Delia spp., Delia platura, Cabbage (Delia radicum); from other species, Pegomya cunicularia );
(5-Ac) Drosophilidae, for example, Drosophila melanogaster, Drosophila suzukii of Drosophila spp .;
(5-Ad) from the Ephydridae family, for example, Hydrellia griseola;
(5-Ae) from the family Psilidae, for example, Psila rosae;
(5-Af) from the family Tephritidae, for example, from Bactrocera spp., Bactrocera cucurbitae, Bactrocera dorsalis; eg, Rhagoletis spp. Fruit flies (Rhagoletis cerasi), Rhagoletis pomonella; other genera species, Ceratitis capitata, olive fruit fly (Dacus oleae).

(5-B) Nematocera
(5-Ba) From the family Cecidomyiidae, for example, the soybean fly (Asphondylia yushimai), the sorghum fly (Contarinia sorghicola), the fly fly (Mayetiola destructor), the squirrel fly fly (Sitodiplosis mosellana).

(6) Grasshopper (Orthoptera) pests (6-a) Acrididae, for example, Schistocerca spp., Schistocerca americana, Schistocerca gregaria; others Of the genus species, Australian flying grasshopper (Chortoicetes terminifera), Moroccan locust (Dociostaurus maroccanus), Tonama locust (Locusta migratoria), Brown locust (Locustana pardalina), Red-necked grasshopper (Nomadacris septemfasciata), Cobaneigo (Oxya zo)
(6-b) from the family Gryllidae, for example, European cricket (Acheta domestica), Teleogryllus emma;
(6-c) from the family Gryllotalpidae, for example, Gryllotalpa orientalis;
(6-d) From the Tettigoniidae family, for example, Tachycines asynamorus.

(7) Tick (Acari)
(7-A) Astigmata (Acaridida)
(7-Aa) Acaridae mites, for example, Rhizoglyphus echinopus, Rhizoglyphus robini; Rhizoglyphus robini; for example, Tyrophagus spp. Tyrophagus neiswanderi, Tyrophagus perniciosus, Tyrophagus putrescentiae, Tyrophagus similius; other genus species, Acarus rogiro mite (Acarus rog

(7-B) Prostigmata mites (Actinedida)
(7-Ba) Tetranychidae mites, for example, Bryobia spp., Clover spider mites (Bryobia praetiosa), Fowl spider mites (Bryobia rubrioculus); For example, Eotetranychus spp .), Eotetranychus asiaticus, Eotetranychus boreus, Eotetranychus celtis, Eotetranychus geniculatus, Teny, E Smith spider mites (Eotetranychus smithi), Sugimen spider mites (Eotetranychus suginamensis), Walnut spider mites (Eotetranychus uncatus); for example, Oligonischus spp. ), Spider mite (Oligonychus mangiferus), sugar cane spider mite (Oligonychus orthius), avocado spider mite (Oligonychus pustulosus), rice spider mite (Oligonychus shinkajii), spider mite (Oligonychus spp. , Citrus spider mites (Panonychus citri), swan spider mites (Panonychus mori), apple spider mites (Panonychus ulmi); , Tetranychus quercivorus, Tetranychus phaselus, Tetranychusurticae, Tetranychus viennensis; For example, Aponicchus spp. hus firmianae); eg, Sasanychus spp., Sasanychus akitanus, Sasanychus pusillus; eg, Shizotetranychus spp., Shizotetranychus spel. Tickling spider mites (Shizotetranychus longus), Shizotetranychus miscanthi, Shizotetranychus schizopus (Taniha, tick, Tetranychina harti) sapporensis);

(7-Bb) Tenuipalpidae mites, for example, Brevipalpus spp., Brevipalpus lewisi, Brevipalpus obovatus, Brevipalpus phoenicis, Cactus (Brevipalpus russulus), brevipalpus californicus; for example, Tenuipalpus pacificus of Tenuipalpus spp., Tenuipalpus zhizhilashviliae; ;
(7-Bc) Eriophyidae mites, for example, Aceria spos., Aceria diospyri, Aceria ficus, Aceria japonica, Aceria kuko , Carnation radish (Aceria paradianthi), black spider mite (Aceria tiyingi), tulip rust mite (Aceriatulipae), Shiba hamakushi mite (Aceria zoysiea); for example, Eriophyes spp., Eriophyes chibaensis Eriophyes emarginatae), for example, Aculops spp., Aculops lycopersici, Aculops pelekassi; eg, Aculus spp., Aculus fockeui, Aculus schlechtendali); from other genera, Acaphylla theavagrans, Yanosabidani (Calacarus carinatus), grape leaf burrowing mite (Colomerus vitis), grape rust mite (Calepitrimerus vitis), Nashisabidani (Epitrimerus pyri), Kinmoku rust mite (Paraphytoptus kikus), Makisabidani (Paracalacarus podocarpi), luchuensis tangerine rust mite (Phyllocotruta citri);
(7-Bd) Mites of the family Transonemidae, for example, Tarsonemus bilobatus, Tarsonemus waitei of Tarsonemus spp .; Phytonemus pallidus of other species , Tea dust mite (Polyphagotarsonemus latus);
(7-Be) Penthaleidae mites, for example, Penthaleus erythrocephalus, Penthaleus major of Penthaleus spp.

The ectoparasites that are subject to control include those that inhabit the back, underarms, lower abdomen, and inner crotch of the host animal and obtain nutrients such as blood and dandruff from the animal, and the back of the host animal. Including those that come to the buttocks and inhabit by obtaining nutrients such as blood and dandruff from animals. Examples of ectoparasites include ticks, lices, fleas, mosquitoes, flies, and flyflies. Specific examples of ectoparasites are shown below.
(1) Tick (Acari)
Dermanyssidae ticks, Macronyssidae ticks, Laelapidae ticks, Varroidae ticks, Argasidae ticks, Ixodidae ticks, cucumber genus mite Psoroptidae mites, Sarcoptidae mites, Knemidokoptidae mites, Demodixidae mites, Trombiculidae mites.
(2) Phythiraptera
Haematopinidae lice, Linognathidae lice, Mennoponidae lice, Philopteridae lice, Trichodectidae lice
(3) Flea eyes (Siphonaptera)
Pulicidae fleas, for example, Ctenocephalides canis, Ctenocephalides felis of Ctenocephalides spp .;
Fleas from the family Tungidae, fleas from the Ceratophyllidae family, and fleas from the Leptopsyllidae family.
(4) Hemiptera
Insects of Cimicidae, Insects of Reduviidae, Insects of Triatominae
(5) Diptera mosquitoes from Culicidae, Simuliidae mosquitoes, Ceratopogonidae mosquitoes, Tabanidae abu, Muscidae flies, Glossinidae, Frostaceae, Flies of Hippoboscidae, Flies of Calliphoridae, Oestridae flies.

In addition, pests that have poisonous needles and venom and cause damage to humans, pests that carry various pathogens and pathogens, and pests that cause discomfort to humans (toxic pests, sanitary pests, unpleasant pests, etc.) Is excellent.
The specific example is shown below.
(1) Hymenoptera pests, Argidae bees, Cynipidae bees, Diprionidae bees, Formicidae ants, Mutillidae bees, A wasp of the vespidae family (Vespidae).
(2) Other pest cockroaches (Blattodea), termites (termite), spiders (Araneae), centipedes (cetipede), millipedes (crustacea), paddybirds (Cimex lectularius).

  The pharmaceutical formulation of the pharmaceutical composition for controlling pests according to the present invention is shown below slightly, but the additives and addition ratios are not limited to these examples, and can be varied in a wide range. The part in a formulation prescription shows a mass part.

Formulation 1 (wettable powder)
Compound A and Compound B 40 parts, diatomaceous earth 53 parts, higher alcohol sulfate 4 parts, and alkyl naphthalene sulfonate 3 parts were uniformly mixed and finely pulverized to obtain a wettable powder of 40% active ingredient. .

Formulation 2 (Emulsion)
30 parts of Compound A and Compound B, 33 parts of xylene, 30 parts of dimethylformamide, and 7 parts of polyoxyethylene alkylallyl ether were mixed and dissolved to obtain an emulsion of 30% active ingredient.

Formulation 3 (Emulsion)
Compound A and Compound B (5 parts), dimethylformamide (93.6 parts), and polyoxyethylene alkylaryl ether (1.4 parts) were mixed and dissolved to obtain an emulsion containing 5% active ingredient.

Formulation 6 (Granule)
Compound A and Compound B (5 parts), talc (40 parts), clay (38 parts), bentonite (10 parts), and sodium alkylsulfate (7 parts) were uniformly mixed and finely pulverized, and then granulated to obtain a diameter of 0.5 to 1 Granules having a diameter of 0.0 mm and an active ingredient of 5% were obtained.

Formulation 7 (Granule)
Compound A and Compound B (5 parts), clay (73 parts), bentonite (20 parts), dioctyl sulfosuccinate sodium salt (1 part), and potassium phosphate (1 part) are thoroughly pulverized and mixed, and water is added to the mixture. The granules were dried to obtain granules containing 5% active ingredient.

Formulation 8 (Suspension)
Compound A and Compound B 10 parts, polyoxyethylene alkyl allyl ether 4 parts, polycarboxylic acid sodium salt 2 parts, glycerin 10 parts, xanthan gum 0.2 parts, and water 73.8 parts are mixed to obtain a particle size of 3 μm or less. To obtain a suspension with 10% active ingredient.

  The pharmaceutical formulation as an ectoparasite control agent is shown below.

Formulation 9 (Granule)
5 parts of Compound A and Compound B were dissolved in an organic solvent to obtain a solution. The solution was sprayed onto 94 parts of kaolin and 1 part of white carbon, and then the solvent was evaporated under reduced pressure to obtain granules. The granules can also be used in admixture with animal food.

Formulation 10 (Injection)
An injection was obtained by uniformly mixing 0.1 to 1 part of Compound A and Compound B and 99 to 99.9 parts of peanut oil, and then filter sterilizing with a sterilizing filter.

Formulation 11 (Pour-on agent)
Compound A and Compound B (5 parts), myristic acid ester (10 parts) and isopropanol (85 parts) were uniformly mixed to obtain a pour-on agent.

Formulation 12 (Spot-on agent)
10-15 parts of compound A and compound B, 10 parts of palmitic acid ester, and 75-80 parts of isopropanol were uniformly mixed to obtain a spot-on agent.

Formulation 13 (Spray agent)
1 part of Compound A and Compound B, 10 parts of propylene glycol, and 89 parts of isopropanol were uniformly mixed to obtain a spray agent.

  Next, the function and effect of the pest control pharmaceutical composition of the present invention will be described.

(Preparation of emulsion for evaluation test)
5 parts of Compound A and / or Compound B, 93.6 parts of dimethylformamide and 1.4 parts of polyoxyethylene alkylaryl ether were mixed and dissolved to prepare an emulsion (I) containing 5% active ingredient.

(Test 1) Efficacy test for chahamaki Emulsion (I) was diluted with water to obtain emulsion dilutions 1a to 3a having concentrations shown in Table 1.
Tea leaves were immersed in the emulsion diluent for 10 seconds. Tea leaves were removed from the emulsion dilution and air-dried. After that, the tea leaves were transferred to a petri dish, and five Chahamaki larvae were released. The petri dish was placed in a constant temperature room at a temperature of 25 ° C. and a humidity of 65%. When 3 days had passed since the release, adults were examined for viability. The test was performed in duplicate.
Table 1 shows the results of the efficacy test on Chahamaki for the emulsion diluents 1a to 3a. The theoretical insecticidal rate E was calculated based on Colby's formula and shown in Table 1.

Colby's formula:
E (%) = X + Y−X × Y / 100
X: Measured insecticidal rate (%) when treated with a chemical solution using Compound A alone
Y: Measured insecticidal rate (%) when treated with a chemical solution using Compound B alone
E: Theoretical insecticidal rate (%) when treated with a chemical solution comprising a combination of Compound A and Compound B

(Test 2) Efficacy test against citrus red mite Emulsion (I) was diluted with water to obtain emulsion dilutions 1b to 3b having the concentrations shown in Table 2.
Citrus leaves were placed in a petri dish, and 10 adult mandarin orange mites were inoculated on the leaves.
The emulsion dilution was sprayed on the citrus leaves using a rotary spray tower. The tangerine leaf was placed in a constant temperature room at a temperature of 25 ° C. and a humidity of 65%. One day after spraying, the life and death of adults were investigated. The test was performed in duplicate.
Table 2 shows the results of the efficacy test against citrus red mite on the emulsion diluents 1a to 3a. The theoretical insecticidal rate E was calculated based on Colby's formula and shown in Table 2.

  From the above results, it can be seen that the pest control method of the present invention synergistically increases the control effect inherent to Compound A or Compound B.

Claims (3)

  3-endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane or a salt thereof 4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyamino) methylene] -2-methylbenzamide or its A method for controlling pests, including application to an object together with salt.   3-endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane or a salt thereof 4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyamino) methylene] -2-methylbenzamide or its A pharmaceutical composition for controlling pests, comprising a salt.   3-endo- [2-propoxy-4- (trifluoromethyl) phenoxy] -9- [5- (trifluoromethyl) -2-pyridyloxy] -9-azabicyclo [3.3.1] nonane or a salt thereof And a pharmaceutical composition containing 4- [5- (3,5-dichlorophenyl) -4,5-dihydro-5- (trifluoromethyl) -3-isoxazolyl] -N-[(methoxyamino) methylene]- A pest control agent set, which is combined with a pharmaceutical composition containing 2-methylbenzamide or a salt thereof without being mixed.