JP2019066398A - Imaging device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide information obtained by near-infrared fluorescence imaging and R.I. I. Provided is an imaging device capable of displaying information obtained by a method in a superimposed manner. An image processing unit includes a near-infrared image generation unit for generating a fluorescence image, a visible image generation unit for generating a visible image, and a count value of a gamma ray detected by a gamma probe. A count value map generation unit 73 that generates a count value map based on the image data, and an image synthesis unit 74 that synthesizes the fluorescence image, the visible image, and the count value map. [Selection diagram] Fig. 4

Description

  The present invention relates to an imaging device which irradiates excitation light to a fluorescent dye administered into the body of a subject and photographs fluorescence generated from the fluorescent dye.

  Conventionally, radioactive isotopes have been introduced in advance as a method of visualizing blood vessels, lymph vessels, lymph nodes, etc. (hereinafter referred to collectively as "lymph nodes etc." when it is difficult to visually identify the inside of a living body in surgery). . I. The law has been used (see Patent Document 1). Here, R. I. Is an abbreviation of Radio Isotope, which is a method of injecting a radioactive isotope into the body and detecting its radiation intensity (gamma dose) with a gamma probe or the like.

  On the other hand, in recent years, a technique called near infrared fluorescence imaging has been used for imaging of lymph nodes and the like in surgery. In this near-infrared fluorescence imaging, indocyanine green (ICG), which is a fluorescent dye, is injected into the body of a subject by an injector or the like to be administered to the affected area. Then, when the indocyanine green is irradiated with near infrared light of about 600 to 850 nm (nanometers) as excitation light, the indocyanine green emits near infrared fluorescence of about 750 to 900 nm. This fluorescence is captured by an imaging element capable of detecting near-infrared light, and the image is displayed on a display unit such as a liquid crystal display panel. According to this near-infrared fluorescence imaging, observation of a lymph node or the like present at a depth of about 20 mm from the body surface becomes possible.

  Also, in recent years, a method of fluorescently labeling a tumor and utilizing it for surgical navigation has attracted attention. As a fluorescent labeling agent for fluorescently labeling a tumor, 5-aminolevulinic acid (5-ALA / 5-Aminolevulinic Acid) is used. When this 5-aminolevulinic acid (hereinafter referred to as "5-ALA" when abbreviated) is administered to a subject, 5-ALA is metabolized to the fluorescent dye PpIX (protoporphyrin IX / protoporphyrin nine) . This PpIX specifically accumulates in cancer cells. Then, when visible light having a wavelength of about 410 nm is irradiated toward PpIX, which is a metabolite of 5-ALA, red visible light having a wavelength of about 630 nm from PpIX is emitted as fluorescence. It is possible to confirm cancer cells by photographing and observing the fluorescence from PpIX with an imaging device.

  In Patent Document 2, an intensity distribution image of near-infrared fluorescence obtained by irradiating excitation light of indocyanine green to a test organ of a living body to which indocyanine green has been administered, and before administration of indocyanine green Is compared with the cancer lesion distribution image obtained by applying X-rays, nuclear magnetic resonance or ultrasound to the subject organ of interest, and detected by the intensity distribution image of near-infrared fluorescence, but the cancer lesion distribution image Discloses a data collection method for collecting data of areas not detected by the above as sub-lesion area data of cancer.

  Further, in Patent Document 3, irradiation of infrared light and visible light to a subject using an illumination / photographing unit in which a camera, an infrared light source, and a visible light source are integrated, and photographing by a camera SUMMARY An imaging apparatus is disclosed that includes an illumination and imaging unit that The illumination and photographing unit is movably supported by the arm. By arranging the illumination and imaging unit toward the subject, it is possible to simultaneously perform irradiation of infrared light and visible light and imaging with a camera on an arbitrary region of the subject. It has become.

International Publication No. 2001/012071 International Publication No. 2009/139466 International Publication No. 2015/092882

  According to the above-mentioned near-infrared fluorescence imaging, it is possible to accurately recognize lymph nodes etc. as an image, but since the reaching depth of excitation light is shallow, lymph nodes etc. in a deep region to the body surface It is impossible to recognize. Therefore, to improve the identification rate of lymph nodes etc., near infrared fluorescence imaging and R.D. I. It is preferable to use the method in combination.

  In such a case, near infrared fluorescence imaging outputs a lymph node or the like as an image. I. The method is to output the radiation intensity for each position of the gamma probe. Thus, near infrared fluorescence imaging and R.S. I. According to the method, it is impossible to simultaneously display the position of a lymph node or the like detected by these methods because the output methods of the results are different from each other. Therefore, in the prior art, R. I. The position of the lymph node detected by the method is marked on the skin of the subject using a marker pen etc. After that, the position of the lymphatic vessel etc. is confirmed on the fluorescence image by near infrared fluorescence imaging. The fact is that

  The present invention was made to solve the above problems, and information obtained by near-infrared fluorescence imaging and R.F. I. An object of the present invention is to provide an imaging apparatus capable of simultaneously and easily confirming information obtained by a method.

  The invention according to claim 1 is characterized in that the excitation light for irradiating the subject with the excitation light for exciting the fluorescent dye administered to the subject is irradiated with the excitation light, and the excitation light is emitted. An imaging unit for capturing fluorescence generated from a fluorescent dye to obtain a fluorescence image, a gamma probe for detecting gamma rays from a radioactive isotope administered to the subject, and a detection unit for gamma rays in the gamma probe Based on the position detection mechanism for detecting the position and the position information of the gamma ray detected by the gamma probe, the display unit detects the position of the detection unit of the gamma ray in the gamma probe detected by the position detection mechanism. And an image processing unit configured to display the fluorescence image by superimposing on the fluorescence image captured by the image processing unit.

  In the invention according to claim 2, in the invention according to claim 1, the image processing unit includes a position of a detection unit of a gamma ray in the gamma probe detected by the position detection mechanism, and a gamma ray detected by the gamma probe. The gamma ray distribution information indicating the relationship with the count value of is generated, and this gamma ray distribution information is superimposed and displayed on the fluorescence image photographed by the photographing unit.

  In the invention according to a third aspect, in the invention according to the first aspect or the second aspect, the position detection mechanism detects a gamma ray in the gamma probe based on an image of the gamma probe captured by the imaging unit. Detect the position of the unit.

  In the invention according to a fourth aspect, in the invention according to the first aspect or the second aspect, the position detection mechanism is based on an image of a marker attached to the gamma probe photographed by the photographing unit. The position of the gamma ray detector in the probe is detected.

  The invention according to claim 5 further includes a visible light source for irradiating the subject with visible light in the invention according to claim 1 or 2, and the position detection mechanism is provided in the imaging unit. The position of the detection unit of the gamma ray in the gamma probe is detected based on the captured visible image of the gamma probe.

  The invention according to a sixth aspect is the invention according to any one of the second to fourth aspects, further comprising a visible light source for irradiating the subject with visible light, and the imaging unit comprises the subject While capturing a visible image by capturing visible light reflected on the surface of the examiner, the image processing unit displays, on the display unit, a composite image obtained by combining the fluorescent image and the visible image obtained by the capturing unit. Do.

  In the invention according to claim 7, in the invention according to claim 6, the image processing unit superimposes the gamma ray distribution information on the composite image, and displays the information on the display unit.

  According to the first aspect of the invention, the imaging unit captures an image of the count value information of gamma rays detected by the gamma probe based on the position of the detection unit of the gamma ray in the gamma probe detected by the position detection mechanism. Information obtained by near-infrared fluorescence imaging displayed by superimposing on a captured fluorescence image and R.F. I. It becomes possible to grasp information obtained by law directly and intuitively.

  According to the second aspect of the invention, the gamma ray distribution information is superimposed on the fluorescence image photographed by the photographing unit based on the gamma ray distribution information acquired by the gamma ray distribution information unit and displayed on the display unit. Information obtained by near infrared fluorescence imaging and R.S. I. It becomes possible to grasp information obtained by law directly and intuitively.

  According to the third aspect of the present invention, the position of the detection unit of the gamma ray in the gamma probe can be detected by using the imaging unit that acquires the fluorescence image.

  According to the fourth aspect of the present invention, it is possible to easily detect the position of the detection unit of the gamma ray in the gamma probe by using the image of the marker.

  According to the fifth aspect of the present invention, it is possible to easily detect the position of the detection unit of gamma rays in the gamma probe using a visible image.

  According to the sixth aspect of the present invention, it is possible to easily recognize the relationship between the fluorescence image and the visible image by displaying the composite image on the display unit.

  According to the seventh aspect of the present invention, it is possible to easily recognize the relationship between the two by superimposing the gamma ray distribution information on the composite image.

FIG. 1 is a perspective view showing an imaging device 1 provided with a region of interest tracking device according to the present invention, together with a display device 2. FIG. 2 is a schematic view of an illumination and photographing unit 12; FIG. 2 is a schematic view of a camera 21 in the illumination / shooting unit 12; FIG. 2 is a block diagram showing a main control system of an imaging apparatus 1 according to the present invention together with a display device 2. FIG. 6 is a schematic diagram showing the coefficient operation of gamma rays from radioactive isotopes using the gamma probe 3; It is a top view which shows the state which scans the acquisition area 100 top of the near-infrared image by near-infrared fluorescence imaging by the gamma probe 3. FIG. It is a schematic diagram showing gamma ray distribution information 103. It is a schematic diagram showing gamma ray distribution information 103. FIG. 2 is a schematic view showing a state in which a near-infrared image 101, a visible image 102, and gamma ray distribution information 103 are combined.

  Hereinafter, embodiments of the present invention will be described based on the drawings. FIG. 1 is a perspective view showing an imaging device 1 according to the present invention together with a display device 2.

  The display device 2 has a configuration in which a display unit 52 configured of a large liquid crystal display device or the like is supported by a support mechanism 51.

  The imaging device 1 irradiates excitation light to indocyanine green as a fluorescent dye injected into the body of a subject, photographs fluorescence consisting of near infrared light emitted from the indocyanine green, and A near-infrared image as a fluorescence image is displayed on the display device 2 together with a color image that is a visible image of the subject, and furthermore, gamma-ray distribution information acquired by the gamma probe 3 is displayed on the display device 2 is there.

  The imaging apparatus 1 includes a carriage 11 having four wheels 13, an arm mechanism 30 disposed on the upper surface of the carriage 11 near the front in the traveling direction of the carriage 11, and the arm mechanism 30 with a sub arm 41. It comprises an illumination / photographing unit 12 and a monitor 15 which are disposed via the same. At the rear of the traveling direction of the carriage 11, a handle 14 used when moving the carriage 11 is attached. Further, on the upper surface of the carriage 11, a recess 16 for mounting an operation unit (not shown) used for remote control of the imaging apparatus 1 is formed.

  The arm mechanism 30 described above is disposed on the front side in the traveling direction of the carriage 11. The arm mechanism 30 includes a first arm member 31 connected by a hinge portion 33 to a support portion 37 disposed on a column 36 erected on the front side in the traveling direction of the carriage 11. The first arm member 31 is pivotable relative to the carriage 11 via the support 36 and the support 37 by the action of the hinge 33. The monitor 15 described above is attached to the support 36.

  A second arm member 32 is connected to an upper end of the first arm member 31 by a hinge portion 34. The second arm member 32 is pivotable relative to the first arm member 31 by the action of the hinge portion 34. Therefore, in the first arm member 31 and the second arm member 32, the first arm member 31 and the second arm member 32 shown in FIG. 1 are the connecting portions between the first arm member 31 and the second arm member 32. It is possible to take an imaging posture in which a predetermined angle is opened around a certain hinge portion 34 and a standby posture in which the first arm member 31 and the second arm member 32 approach each other.

  At the lower end of the second arm member 32, a support portion 43 is connected by a hinge portion 35. The support portion 43 can swing relative to the second arm member 32 by the action of the hinge portion 35. The rotation shaft 42 is supported by the support portion 43. Then, the sub arm 41 supporting the illumination / photographing unit 12 pivots around a rotation shaft 42 disposed at the tip of the second arm member 32. For this reason, the illumination / photographing unit 12 positions the front side of the traveling direction of the carriage 11 with respect to the arm mechanism 30 for taking the photographing attitude or the standby attitude shown in FIG. The carriage 11 moves between a position on the rear side in the direction of travel of the carriage 11 with respect to the arm mechanism 30 which is a posture for moving 11.

  FIG. 2 is a schematic view of the illumination and photographing unit 12.

  The illumination / shooting unit 12 includes a camera 21 having a plurality of imaging elements capable of detecting near-infrared rays and visible light described later, and a visible light source 22 including six LEDs disposed around the periphery of the camera 21. , An excitation light source 23 consisting of six LEDs, and a confirmation light source 24 consisting of one LED. The visible light source 22 emits visible light. The excitation light source 23 emits near-infrared light having a wavelength of 760 nm, which is excitation light for exciting indocyanine green. The confirmation light source 24 emits near-infrared light having a wavelength of 810 nm, which is close to the wavelength of the fluorescence generated from indocyanine green. The wavelength of the excitation light source 23 is not limited to 760 nm, and may be a wavelength that can excite indocyanine green. The wavelength of the confirmation light source 24 is not limited to 810 nm, and may be equal to or longer than the wavelength emitted by indocyanine green.

  FIG. 3 is a schematic view of the camera 21 in the illumination / shooting unit 12.

  The camera 21 includes a movable lens 54 that reciprocates for focusing, a wavelength selection filter 53, an imaging device 55 for visible light, and an imaging device 56 for fluorescence. The visible light imaging device 55 and the fluorescence imaging device 56 are formed of a CMOS or a CCD. In addition, as the imaging device 55 for visible light, one capable of capturing an image of visible light as a color image is used.

  The visible light and the fluorescence coaxially incident on the camera 21 along the optical axis L reach the wavelength selection filter 53 after passing through the movable lens 54 constituting the focusing mechanism. The visible light of the visible light and the fluorescent light which are coaxially incident is reflected by the wavelength selection filter 53 and is incident on the visible light imaging element 55. Further, among the visible light and the fluorescence that are coaxially incident, the fluorescence passes through the wavelength selection filter 53 and is incident on the fluorescence imaging element 56. At this time, visible light is focused on the visible light imaging element 55 and fluorescence is focused on the fluorescent light imaging element 56 by the action of a focusing mechanism including the movable lens 54. The visible light imaging element 55 captures a visible image as a color image at a predetermined frame rate. Further, the fluorescence imaging element 56 captures a near infrared image which is a fluorescence image according to the present invention at a predetermined frame rate.

  FIG. 4 is a block diagram showing the main control system of the imaging apparatus 1 according to the present invention together with the display device 2. As shown in FIG.

  The imaging apparatus 1 includes a CPU that executes logical operations, a ROM that stores an operation program required to control the apparatus, a RAM that temporarily stores data etc. during control, and controls the entire apparatus. A unit 60 is provided. The control unit 60 is connected to the gamma probe 3. The gamma probe 3 is for detecting the radiation intensity (count value of gamma rays) by the radioactive isotope injected into the body of the subject.

  The control unit 60 also includes an image acquisition unit 61 for acquiring an image taken by the camera 21 and a position detection unit 62 for detecting the position of a gamma ray detection unit in the gamma probe 3 on the body surface of the subject. And a count value acquisition unit 63 for acquiring the count value of gamma rays detected by the gamma probe 3. The control unit 60 is connected to the illumination / photographing unit 12 including the camera 21, the visible light source 22, the excitation light source 23 and the confirmation light source 24.

  The imaging apparatus 1 further includes an image processing unit 70 connected to the control unit 60. The image processing unit 70 uses the near infrared image generation unit 71 for generating a near infrared image, the visible image generation unit 72 for generating a visible image, and the count value of gamma rays detected by the gamma probe 3. A count value map generation unit 73 that generates a count value map based on the above, and an image combining unit 74 that combines a near infrared image, a visible image, and the count value map. The image processing unit 70 is connected to the display device 2 described above.

  FIG. 5 is a schematic diagram showing the coefficient operation of gamma rays from radioactive isotopes using the gamma probe 3. Further, FIG. 6 is a plan view showing a state in which the gamma probe 3 scans over the acquisition region 100 of the near infrared image by the near infrared fluorescence imaging.

  When performing the coefficient operation by the gamma probe 3, the operator grips the gripping portion 81 of the gamma probe 3 and moves the gamma ray detection portion 82 of the gamma probe 3 in parallel to the body surface of the subject M. As shown in FIG. 6, the scanning region of the gamma ray detection unit 82 in the gamma probe 3 is a region capable of scanning the entire near infrared image acquisition region 100 by near infrared fluorescence imaging. However, only a part of the acquisition region 100 of the near-infrared image by near-infrared fluorescence imaging may be scanned.

  The count value of the gamma ray detected by the gamma probe 3 at this time is acquired by the count value acquisition unit 63. At this time, the count value of the gamma ray detected by the gamma probe 3 is acquired by the count value acquisition unit 63 as digital information. A configuration may be adopted in which the sound generated when the gamma probe 3 detects a gamma ray is collected by a microphone or the like and this value is acquired by the count value acquisition unit 63.

  A position marker 83 is attached near the gamma ray detection unit 82 in the gamma probe 3. As this position marker 83, for example, one that emits fluorescence of a special wavelength and can recognize its position on the near-infrared image acquired by the camera 21 is used. Moreover, even if using what has a color such as green which does not exist in the living body of the subject M as this position marker 83, and using that whose position can be recognized on the visible image acquired by the camera 21 is used. Good. The image of the position marker 83 acquired by the camera 21 is recognized by the position detection unit 62 in the control unit 60, and the position of the gamma ray detection unit 82 in the gamma probe 3 at that time is specified.

  It should be noted that instead of detecting the position of the gamma ray detection unit 82 in the gamma probe 3 using the position marker 83 attached near the gamma ray detection unit 82 in the gamma probe 3, the visible image obtained by the camera 21 is an image The position of the detection unit 82 of the gamma ray in the gamma probe 3 may be detected by processing and recognizing the outer shape of the gamma probe 3. Alternatively, the position of the gamma ray detection unit 82 in the gamma probe 3 may be detected using position detection means such as a digitizer.

  7 and 8 are schematic diagrams showing the gamma ray distribution information 103. FIG.

  The relationship between the position of the detection unit 82 of the gamma ray in the gamma probe 3 detected by the position detection unit 62 and the count value of the gamma ray detected by the gamma value acquisition unit 63 at that time is image processing It is sent to the part 70. Then, the count value map generation unit 73 in the image processing unit 70 creates the gamma ray distribution information 103 indicating the relationship between the position of the gamma ray detection unit 82 in the gamma probe 3 and the count value of gamma rays detected by the gamma probe 3. The gamma ray distribution information 103 is information representing the count value of gamma rays with respect to the position of the subject M.

  For example, as schematically shown in FIG. 7, the gamma ray distribution information 103 is displayed as an image in which the luminance is higher as the count value of the gamma ray is larger, and the luminance is lower as the count value is smaller. Further, for example, as schematically shown in FIG. 8, the count value of the position at which the gamma ray is measured may be displayed by a numeral.

  When performing surgery on the subject M using the imaging apparatus 1 having the above-described configuration, first, the confirmation light source 24 in the illumination / photographing unit 12 is turned on, and the image of the irradiation area is displayed. The image is taken by the camera 21. The confirmation light source 24 emits near infrared light having a wavelength of 810 nm, which is close to the wavelength of the fluorescence generated from indocyanine green. This near infrared light can not be confirmed by human eyes. On the other hand, when near-infrared light having a wavelength of 810 nm is emitted from the confirmation light source 24 and an image of the irradiated area is taken by the camera 21, near-infrared light is obtained when the camera 21 is operating normally. The image of the illuminated area is photographed by the camera 21, and the image is displayed on the display unit 52 of the display device 2. This makes it possible to easily check the operation of the camera 21.

  Thereafter, subject M is injected with indocyanine green by injection. Then, toward the affected area in the tissue of the subject M, near-infrared light is emitted from the excitation light source 23 in the illumination / photographing unit 12 and visible light is emitted from the visible light source 22. As the near infrared light emitted from the light source 23 for excitation, as described above, the near infrared light of 760 nm which acts as excitation light for causing the indocyanine green to emit fluorescence is employed. Thereby, the indocyanine green injected into the body of the subject M generates fluorescence in the near infrared region with a peak of about 800 nm.

  Then, the vicinity of the affected area in the tissue of the subject M is photographed by the camera 21 in the illumination / photographing unit 12 at a predetermined frame rate. As described above, this camera 21 can detect near infrared light and visible light. The near infrared image which is a fluorescence image taken at a predetermined frame rate by the camera 21 can be displayed on the display unit 52 of the display device 2 by the near infrared image generation unit 71 of the image processing unit 70 The image data is converted into 8-bit image data and displayed on the display unit 52 as necessary. Further, the visible image captured at a predetermined frame rate by the camera 21 is configured by the visible image generation unit 72 in the image processing unit 70 in three colors of RGB that can display the visible image on the display unit 52 in the display device 2. The image data is converted into 24-bit image data and displayed on the display unit 52 as necessary.

  In addition, a radioactive isotope is injected into the subject M as a tracer on the day before surgery and the like. The gamma ray from this radioisotope is, as described above, moved by the operator in parallel to the body surface of the subject M by the gamma ray detector 82 of the gamma probe 3, the detector 82 of the gamma probe 3 The position and the count value at that time are measured. Then, the gamma ray indicating the relationship between the position of the gamma ray detection unit 82 in the gamma probe 3 shown in FIG. 7 or 8 and the count value of gamma rays detected by the gamma probe 3 by the count value map generation unit 73 in the image processing unit 70 Distribution information 103 is created. The gamma ray distribution information 103 is displayed on the display unit 52 of the display device 2 as necessary.

  FIG. 9 is a schematic view showing a state in which the near infrared image 101, the visible image 102, and the gamma ray distribution information 103 are combined.

  While performing the operation on the subject M, the image combining unit 74 in the image processing unit 70 displays the combined image 104 of the near infrared image 101, the visible image 102, and the gamma ray distribution information 103 on the display device 2 It is displayed on the part 52. Instead of displaying the composite image 104 of the near infrared image 101, the visible image 102, and the gamma ray distribution information 103 on the display unit 52, a composite image of the near infrared image 101 and the gamma ray distribution information 103, or visible A composite image of the image 102 and the gamma ray distribution information 103 may be displayed on the display unit 52.

  As described above, by displaying the composite image 104 of the near infrared image 101, the visible image 102, and the gamma ray distribution information 103 on the display unit 52, the near infrared image 101, which is a highly accurate image, can be obtained. It becomes possible to add and display the gamma ray distribution information 103 provided with depth information. This enables the operator to directly and intuitively identify the identification of a lymph node or the like.

  In the embodiment described above, the illumination / imaging unit 12 in which the visible light source 22, the excitation light source 23, the confirmation light source 24, and the camera 21 are integrated is used, but the visible light source 22 and the excitation light source The light source 23 and the light source 24 for confirmation and the camera 21 may be separately provided. Also, the confirmation light source 24 may be omitted.

  Moreover, although the structure which acquires the visible image 102 of the to-be-tested person M is employ | adopted in embodiment mentioned above, you may confirm the visible image 102 visually.

DESCRIPTION OF SYMBOLS 1 imaging apparatus 2 display apparatus 3 gamma probe 12 illumination / imaging part 21 camera 22 visible light source 23 excitation light source 24 confirmation light source 30 arm mechanism 52 display part 60 control part 61 image collection part 62 position detection part 63 count value acquisition part 70 Image processing unit 71 Near infrared image generation unit 72 Visible image generation unit 73 Count value map generation unit 74 Image combining unit 81 Holding unit 82 Gamma ray detection unit 83 Position marker C Lymphatic vessel N Lymph node M Subject

Claims (7)

An excitation light source for irradiating the subject with excitation light for exciting the fluorescent dye administered to the subject;
An imaging unit that captures fluorescence generated from the fluorescent dye upon irradiation with excitation light to obtain a fluorescence image;
A gamma probe for detecting gamma rays from radioisotopes administered to the subject;
A position detection mechanism for detecting a position of a detection unit of gamma rays in the gamma probe;
The display unit superimposes, on the display unit, the fluorescence image captured by the imaging unit on the basis of the position of the detection unit of the gamma ray detected by the position detection mechanism. The image processing unit to display
An imaging apparatus comprising: In the imaging apparatus according to claim 1,
The image processing unit creates gamma ray distribution information indicating the relationship between the position of the gamma ray detection unit in the gamma probe detected by the position detection mechanism and the count value of gamma rays detected by the gamma probe, and the gamma ray distribution information And an imaging device for displaying the fluorescence image superimposed on the fluorescence image captured by the imaging unit. In the imaging apparatus according to claim 1 or 2,
The position detection mechanism is an imaging device that detects a position of a detection unit of gamma rays in the gamma probe based on an image of the gamma probe captured by the imaging unit. In the imaging apparatus according to claim 1 or 2,
The imaging apparatus detects the position of a gamma ray detection unit in the gamma probe based on an image of a marker attached to the gamma probe captured by the imaging unit. In the imaging apparatus according to claim 1 or 2,
It further comprises a visible light source for irradiating the subject with visible light,
The imaging apparatus detects the position of a gamma ray detection unit in the gamma probe based on a visible image of the gamma probe captured by the imaging unit. The imaging apparatus according to any one of claims 2 to 4
It further comprises a visible light source for irradiating the subject with visible light,
The imaging unit acquires a visible image by capturing visible light reflected by the surface of the subject.
The imaging device displays the combined image obtained by combining the fluorescence image acquired by the imaging unit and the visible image on the display unit. In the imaging apparatus according to claim 6,
The imaging apparatus, wherein the image processing unit superimposes the gamma ray distribution information on the composite image, and displays the information on the display unit.

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