JP2018162232A - Coated chlorine tablet and chlorine tablet package - Google Patents

Abstract

[PROBLEMS] To improve the handleability of chlorinating agents and to maintain sufficient water solubility even when stored for a long period of time. Provided is a coated chlorine tablet that can be improved and can suppress a decrease in water solubility of a water-soluble film. Moreover, the chlorine agent tablet packaging body in which this coated chlorine agent tablet was packaged with a water-soluble film is provided. A coated chlorinated tablet having a sugar-coated layer on the surface of a chlorinated tablet, wherein the chlorinated tablet contains a chlorine-containing compound, and the sugar-coated layer contains 30% by weight or more of a saccharide. Chlorine tablets. [Selection figure] None

Description

The present invention improves the handleability of the chlorinating agent and can sufficiently maintain water solubility even when stored for a long period of time. The present invention relates to a coated chlorinating tablet that can be further improved and can suppress a decrease in water solubility of a water-soluble film. The present invention also relates to a chlorinated tablet package in which the coated chlorinated tablet is packaged with a water-soluble film.

Conventionally, chlorine agents have been widely used for applications such as sterilization, disinfection, and cleaning.
Since the chlorinating agent is a drug that is dangerous for direct contact, it is usually used in the form of a tablet or the like in order to improve the handleability.
Chlorine tablets generate chlorine gas due to moisture absorption, so problems such as odors associated with the generation of chlorine gas during storage, sterilization in the use environment associated with decomposition during storage, and deterioration in cleanability, etc. There was a problem.
With respect to such a problem, Patent Document 1 describes a method of stabilizing a chlorine agent tablet by attaching a powder such as a metal stearate salt to the surface of the tablet.
However, there is a problem that the powder is detached during storage and the generation of odor cannot be sufficiently suppressed. In addition, there is a risk of direct contact with the skin during use and storage, and it is necessary to improve safety during handling.

In order to improve the storage safety of such a drug and improve the safety during handling of the drug, Patent Document 2 proposes a method of coating a chlorinated tablet with a water-soluble film made of acrylic acid or the like. ing.
However, the coating layer made of a water-soluble film specified in Patent Document 2 has a problem that the dissolution in water is slow and the generation of chlorine from the chlorinated tablet is inhibited. In addition, since the coating layer is hard and brittle, the coating layer is damaged during storage, and there is a problem that odor is generated from the chlorine tablet.

On the other hand, a method for coating a chlorinated tablet with a coating layer using a water-soluble film made of a polyvinyl alcohol resin has been proposed. Since the polyvinyl alcohol-based resin is excellent in water solubility, the dissolution of the coating layer in water can be accelerated. Moreover, since it is excellent also in mechanical strength, damage to the coating layer during storage can be prevented. As a coating layer using such a polyvinyl alcohol-based resin, Patent Document 3 discloses the use of a water-soluble film obtained by adding a plasticizer and a sulfite to a polyvinyl alcohol-based resin.
However, if a chlorinated tablet with a coating layer using a polyvinyl alcohol resin is stored for a long period of time, the coating layer deteriorates due to the chlorinated tablet, water solubility decreases, and a large amount of undissolved components are generated when the drug is used. And the problem of inhibiting the generation of chlorine gas from the chlorinated tablets has occurred.

JP 60-199803 A JP 2004-182773 A JP 2005-179390 A

The present invention improves the handleability of the chlorinating agent and can sufficiently maintain water solubility even when stored for a long period of time. It is an object of the present invention to provide a coated chlorine tablet that can be further improved and can suppress a decrease in water solubility of a water-soluble film. It is another object of the present invention to provide a chlorinated tablet packaging in which the coated chlorinated tablets are packaged with a water-soluble film.

The present invention is a coated chlorinated tablet having a sugar coating layer on the surface of a chlorinated tablet, wherein the chlorinated tablet contains a chlorine-containing compound, and the sugar coated layer contains 30% by weight or more of a saccharide. Chlorine tablet.
The present invention is described in detail below.

The present inventor can improve the safety during handling by coating a tablet-like chlorine agent with a sugar-coating layer containing a saccharide, and suppresses a decrease in water solubility even after long-term storage. I found out that I can do it. Furthermore, it has been found that by using such a chlorinating tablet in combination with a water-soluble film, it is possible to achieve the suppression of off-flavor and the prevention of deterioration of the water-soluble film, and the present invention has been completed.

The coated chlorine tablet of the present invention has a structure in which a chlorine tablet containing a chlorine-containing compound is coated with a sugar coating layer containing 30% by weight or more of a saccharide.
Since the coated chlorine preparation tablet of the present invention has the above-described configuration, it can be used without directly touching a chlorine-containing compound that is dangerous to be in direct contact because of its strong oxidizing ability.
In addition, with conventional coatings using water-soluble films, the water solubility of the film has been a problem, but the sugar-coated layer is less likely to lose water solubility even when in contact with chlorine-containing compounds, improving long-term storage stability. Can be made.
Furthermore, since the coated chlorine tablet of the present invention has a sugar coating layer, the chlorine-containing compound and the water-soluble film are not in direct contact with each other even when sealed with a water-soluble film. However, the water-soluble fall of a film can be suppressed and generation | occurrence | production of an odor can be suppressed more effectively.

The chlorine agent tablet contains a chlorine-containing compound.
The chlorine-containing compound generates chlorine gas.
Chlorine-containing compounds are substances containing chlorine in the molecule, such as chlorine oxoacids and salts thereof, such as chloric acid, hypochlorous acid, zinc basic acid, perchloric acid, chlorinated isocyanuric acid and salts thereof, etc. Is mentioned. Specific examples include hypochlorous acid, sodium hypochlorite, calcium hypochlorite, dichloroisocyanuric acid, sodium dichloroisocyanurate, calcium hypochloroisocyanurate, trichloroisocyanuric acid and the like. Of these, chlorinated isocyanuric acid and salts thereof are preferable, and trichloroisocyanuric acid is particularly preferable.

Content of the said chlorine containing compound in the said chlorine agent tablet can be adjusted according to a usage method and a use environment, and a preferable minimum is 10 weight%.
When the content of the chlorine-containing compound is 10% by weight or more, the effective chlorine concentration is set to an appropriate concentration, and the bactericidal property and the cleaning property can be sufficiently exhibited.
The more preferable lower limit of the content of the chlorine-containing compound is 40% by weight, and the more preferable lower limit is 80% by weight.
The upper limit of the content of the chlorine-containing compound in the chlorine-containing tablet is not particularly limited, but in the present invention, it is possible to improve the handling of a chlorine-containing tablet having a high content of chlorine-containing compound, which was difficult in the past. is there. The upper limit with preferable content of the said chlorine containing compound is 100 weight%.

The chlorinated tablets may further contain additives such as excipients, surfactants and binding aids. By containing such an additive, the shape retention of the chlorine tablet can be improved, and the generation of chlorine when dissolved in water can be moderated to control the effective chlorine concentration. .

Examples of the excipient include lactose, starch, trehalose, anhydrous hydrogen phosphate, organic acid, carbonate, bicarbonate and the like.
Organic acids include benzoic acid, citric acid, tartaric acid, malic acid, gluconic acid, fumaric acid, succinic acid, adipic acid, glutaric acid, maleic acid, lactic acid, malonic acid, aspartic acid, glutamic acid, ascorbic acid, itaconic acid, Examples include mesaconic acid and salicylic acid.
Examples of the carbonate and bicarbonate include sodium salt and potassium salt.

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, or an amphoteric surfactant can be used.

Examples of the anionic surfactants include carboxylic acid type anionic surfactants such as aliphatic monocarboxylates, polyoxyethylene alkyl ether carboxylates, N-acyl sarcosine salts, N-acyl glutamates, and dialkyl sulfosuccinates. Acid salts, alkyl sulfonates, α-olefin sulfonates, alkyl benzene sulfonates, naphthalene sulfonate-formaldehyde condensates, alkyl naphthalene sulfonates, N-methyl-N-acyl taurine salts, etc. Surfactants, alkyl sulfates, polyoxyethylene alkyl ether sulfates, fat and oil sulfates, sulfate anion surfactants such as castor oil sulfated oils, alkyl phosphates, polyoxyethylene alkyl ether phosphates Salt, polyoxyethylene alkylpheny Phosphoric acid ester type anionic surface active agents such as ether phosphoric acid salts.

Examples of the cationic surfactant include quaternary ammonium salt type cationic surfactants such as alkyltrimethylammonium chloride, alkyltriethylammonium chloride, dialkyldimethylammonium chloride, and alkylpyridinium chloride.

Examples of nonionic surfactants include fatty acid diethanolamide, polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, glycerin fatty acid ester, sorbitan fatty acid ester, and sucrose fatty acid ester.

Examples of zwitterionic surfactants include alkylcarboxybetaines, alkylsulfoxybetaines, alkylamidohydroxysulfobetaines, alkylamidoamine-type betaines, and alkylimidazoline-type betaines.

Examples of the binding aid include carboxymethylcellulose, sodium carboxymethylcellulose, dextrin, polyethylene glycol, polyvinyl alcohol, polyalkylene glycol, gum arabic, and starch.

The method for producing the chlorinated tablet is not particularly limited. For example, there is a method in which a powdery or granular raw material is filled into a pressure-type tableting machine composed of a mold and a pressure device and tableted. Can be mentioned.
As a pressure-type tableting machine, a single-punch tableting machine for tableting one tablet at a time, a plurality of people are installed along a rotating disk, and during this one rotation, filling of raw materials, pressure molding, A rotary tableting machine or the like that continuously takes out can be used.

The shape of the chlorinated tablet is not particularly limited, and is appropriately set in consideration of handleability.
Examples of the shape of the chlorinated tablet include a cylindrical shape, an elliptical column shape, a triangular column shape, a quadrangular column shape, other polygonal column shapes, and a spherical shape.

The coated chlorine tablet of the present invention has a sugar coating layer on the surface of the chlorine tablet.
The sugar coating layer may be formed so as to cover the entire surface of the chlorinated tablet, or may be formed on a part of the surface of the chlorinated tablet.
The sugar coating layer contains a carbohydrate.
Sugar dissolves or disperses 99% by weight or more when dissolved in water, and the coated chlorine tablet of the present invention can be dissolved directly by contact with water. And can be handled safely. Moreover, generation | occurrence | production of the chlorine gas from a chlorine agent tablet can be suppressed at the time of storage, and when using it, sufficient bactericidal and detergency can be exhibited, without inhibiting generation | occurrence | production of chlorine gas.

As the saccharide, it is preferable that a monosaccharide unit constituting the saccharide has two or more hydroxyl groups. When the monosaccharide unit constituting the saccharide has two or more hydroxyl groups, chlorine gas generated from the chlorinating tablet can be captured.
More preferably, the saccharide has a monosaccharide unit having three or more hydroxyl groups.
In the present invention, the monosaccharide unit may be composed of a monosaccharide or a derivative of a monosaccharide.

Examples of the saccharide include saccharides such as monosaccharides and disaccharides, polysaccharides of trisaccharides or more, and derivatives thereof, and saccharides are preferable. Moreover, it is preferable that the monosaccharide unit which comprises the said carbohydrate has a 6-membered ring structure and / or a 5-membered ring structure.

Examples of the monosaccharide include arabinose, galactose, xylose, glucose (glucose), sorbose, fructose, rhamnose, ribose, N-acetylglucosamine and the like.

Examples of the disaccharide include heterodisaccharides and homodisaccharides, and specific examples include trehalose, maltose, isomaltose, cellobiose, gentiobiose, melibiose, lactose, sucrose (sucrose), palatinose, and the like.

Examples of the polysaccharides above the trisaccharides include hetero-oligosaccharides, homo-oligosaccharides, and the like. Specifically, maltotriose, isomaltotriose, panose, cellotriose, manninotriose, solatriose, melistose, planteose, Examples include trisaccharides such as gentianose, umbelliferose, lactosucrose, and raffinose, and tetrasaccharides such as maltotetraose, isomaltotetraose, stachyose, cellotetraose, scorodose, and liquinose.

Examples of the derivatives include amino sugars, sugar alcohols, and uronic acids.
Examples of the amino sugar include glucosamine, galactosamine, mannosamine, neuraminic acid, muramic acid and the like.
Examples of the sugar alcohol include isomaltitol, maltitol, xylitol, erythritol, glycerol, sorbitol, reduced palatinose, mannitol, lactitol and the like.
Examples of the uronic acid include glucuronic acid, iduronic acid, galacturonic acid, guluronic acid, mannuronic acid and the like.

Especially, as said saccharide | sugar, saccharides, such as a monosaccharide and a disaccharide, are preferable, and glucose and sucrose are more preferable.
The above carbohydrates may be used alone, or a plurality of types of sugars may be combined in any proportion.

The upper limit of the molecular weight of the saccharide is preferably 1000.
When the sugar has a molecular weight of 1000 or less, sufficient water solubility can be exhibited even when exposed to chlorine gas generated from a chlorinating tablet.
The lower limit of the molecular weight of the saccharide is preferably 100, and the upper limit is preferably 700.

The melting point of the carbohydrate is preferably 30 ° C. or higher.
When the melting point of the sugar is 30 ° C. or higher, it is possible to prevent the sugar coating layer from melting and exposing the chlorine coating tablet when storing the coated chlorine coating tablet.
A more preferable lower limit of the melting point of the saccharide is 40 ° C., and a more preferable lower limit is 50 ° C. The upper limit of the melting point of the saccharide is not particularly limited, but a preferable upper limit is 300 ° C.

The sugar content in the sugar coating layer is 30% by weight or more.
When the sugar content is 30% by weight or more, the solubility of the sugar-coating layer is improved, and the sugar-coating layer dissolves quickly when it comes into contact with water, and the generation of chlorine gas from the chlorine tablet It can be expected that the diffusion of chlorine gas generated from the chlorinated tablets can be suppressed without hindering.
The more preferable lower limit of the saccharide content is 50% by weight, and the still more preferable lower limit is 70% by weight. The upper limit of the saccharide content is not particularly limited, but a preferable upper limit is 100% by weight.

The sugar coating layer may contain excipients, binders, colorants and the like in addition to the sugar.

Examples of the excipient include talc, precipitated calcium carbonate, calcium monohydrogen phosphate, calcium hydrogen phosphate, sodium hydrogen phosphate, dipotassium phosphate, potassium dihydrogen phosphate, calcium dihydrogen phosphate, dihydrogen phosphate. Sodium, calcium sulfate, calcium lactate, titanium oxide, kaolin, hydrous silicon dioxide, synthetic aluminum silicate, synthetic hydrosite, dry aluminum hydroxide, magnesium carbonate, magnesium oxide, light anhydrous silicic acid, magnesium stearate, calcium stearate, Examples thereof include sugar fatty acid esters, crospovidone, carmellose, croscarmellose sodium, carmellose calcium, carmellose sodium, carboxymethyl ethyl cellulose, and carboxy starch sodium.

Examples of the binder include gum arabic, pullulan, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, hydroxyethylcellulose, crystalline cellulose, powdered cellulose, low-substituted hydroxypropylcellulose, dextrin, corn starch, pregelatinized starch, and partially pregelatinized starch. , Hydroxypropyl starch, polyvinylpyrrolidone (PVP), carboxyvinyl polymer, polyvinyl alcohol (PVA), crystalline cellulose / carmellose sodium, gelatin, xanthan gum, tragacanth and the like.

A preferable lower limit of the thickness of the sugar coating layer is 0.01 mm, and a preferable upper limit is 5 mm.
When the coated sugar coating tablet has a thickness of 0.01 mm or more, it prevents the chlorine coating tablet from being exposed due to cracking or melting of the sugar coating layer and the generation of odor due to chlorine gas when the coated coating is stored. Can do. When the thickness of the sugar-coating layer is 5 mm or less, the sugar-coating layer is easily melted when contacted with water, and generation of chlorine gas from the chlorine-containing tablet can be hardly inhibited.
The more preferable lower limit of the thickness of the sugar coating layer is 0.5 mm, and the more preferable upper limit is 3 mm.

A method for forming the sugar coating layer is not particularly limited, but a method of spraying and drying the coating liquid containing the sugar on the chlorine tablet, and a method of spraying the coating liquid containing the sugar onto the chlorine tablet Examples thereof include a method of coating and drying, a method of immersing the chlorinated tablet in a coating solution containing the sugar and drying it.

The coating liquid may be a solution in which a saccharide is made liquid by heating and melting the saccharide, or a saccharide solution in which a saccharide is dissolved in a solvent.

The content of the saccharide in the coating solution depends on the solubility of the saccharide used in the solvent, but it is preferable that the concentration be as high as possible. A preferred lower limit is 50% or more of the saturated solution concentration. Moreover, the upper limit of the content of the saccharide in the coating solution is not particularly limited, but a preferable upper limit is a saturated solution concentration or a solution concentration that becomes supersaturated.

When the coating liquid contains a solvent, it is not particularly limited as long as it does not remain in the coated chlorine tablet of the present invention, but as the solvent, water, alcohols, etc. are used. Can do.

By packaging the coated chlorine tablet of the present invention with a water-soluble film, the storage stability of the coated chlorine tablet can be further improved.
Further, since the coated chlorine tablet of the present invention has a sugar coating layer, even when the content is a chlorine-containing compound, discoloration of the water-soluble film and reduction in water solubility can be suppressed when stored for a long period of time.
A chlorinated tablet package in which the coated chlorinated tablets of the present invention are packaged with a water-soluble film is also one aspect of the present invention.

The chlorinated tablet packaging of the present invention has a water-soluble film.
The chlorinated tablet package of the present invention may be one in which a layer made of a water-soluble film is formed on the surface of the chlorinated tablet, and the chlorinated tablet is contained in a container made of a water-soluble film. May be.
By having such a structure, it is possible to suppress the deterioration of the coated chlorine tablet and the generation of odor. Moreover, by having a water-soluble film, it is not necessary to unwrap the packaging at the time of use, and the coated chlorine tablet can be handled more safely.

The water-soluble film preferably contains polyvinyl alcohol.
The polyvinyl alcohol is obtained by polymerizing a vinyl ester to obtain a polymer according to a conventionally known method, and then saponifying the polymer, that is, hydrolyzing. For saponification, an alkali or an acid is generally used. It is preferable to use an alkali for the saponification. As said polyvinyl alcohol, only 1 type may be used and 2 or more types may be used together.

Examples of the vinyl ester include vinyl acetate, vinyl formate, vinyl propionate, vinyl butyrate, vinyl pivalate, vinyl versatate, vinyl laurate, vinyl stearate and vinyl benzoate.

The method for polymerizing the vinyl ester is not particularly limited. Examples of the polymerization method include a solution polymerization method, a bulk polymerization method, and a suspension polymerization method.

Examples of the polymerization catalyst used when polymerizing the vinyl ester include 2-ethylhexyl peroxydicarbonate (“TrigonoxEHP” manufactured by Tianjin McEIT), 2,2′-azobisisobutyronitrile (AIBN), t-butyl. Peroxyneodecanoate, bis (4-t-butylcyclohexyl) peroxydicarbonate, di-n-propylperoxydicarbonate, di-n-butylperoxydicarbonate, di-cetylperoxydicarbonate and di-s-butylperoxy Examples include dicarbonate. As for the said polymerization catalyst, only 1 type may be used and 2 or more types may be used together.

Since the degree of saponification is easily controlled within a suitable range, the polymer obtained by polymerizing the vinyl ester is preferably a polyvinyl ester. The polymer obtained by polymerizing the vinyl ester may be a copolymer of the vinyl ester and another monomer. That is, the polyvinyl alcohol may be formed using a copolymer of vinyl ester and another monomer. Examples of the other monomers, that is, comonomers to be copolymerized, include olefins, (meth) acrylic acid and salts thereof, (meth) acrylic acid esters, (meth) acrylamide derivatives, N-vinylamides, vinyl ethers, and nitriles. , Vinyl halides, allyl compounds, maleic acid and salts thereof, maleic acid esters, itaconic acid and salts thereof, itaconic acid esters, vinylsilyl compounds, and isopropenyl acetate. As for the other monomer, only one kind may be used, or two or more kinds may be used in combination.

Examples of the olefins include ethylene, propylene, 1-butene and isobutene. Examples of the (meth) acrylic acid esters include methyl (meth) acrylate, ethyl (meth) acrylate, n-propyl (meth) acrylate, i-propyl (meth) acrylate, and (meth) acrylic acid n-. Examples include butyl and 2-ethylhexyl (meth) acrylate. Examples of the (meth) acrylamide derivative include acrylamide, n-methylacrylamide, N-ethylacrylamide, N, N-dimethylacrylamide, and (meth) acrylamidepropanesulfonic acid and salts thereof. Examples of the N-vinyl amides include N-vinyl pyrrolidone. Examples of the vinyl ethers include methyl vinyl ether, ethyl vinyl ether, n-propyl vinyl ether, i-propyl vinyl ether, and n-butyl vinyl ether. Examples of the nitriles include (meth) acrylonitrile. Examples of the vinyl halides include vinyl chloride and vinylidene chloride. Examples of the allyl compound include allyl acetate and allyl chloride. Examples of the vinylsilyl compound include vinyltrimethoxysilane.

When the polyvinyl alcohol and the other monomer are copolymerized to obtain a modified PVA, the modification amount is preferably 15 mol% or less, more preferably 5 mol% or less. That is, in the total 100 mol% of the structural unit derived from the vinyl ester in the modified PVA and the structural unit derived from the other monomer, the structural unit derived from the vinyl ester is preferably 85 mol% or more, more preferably 95 mol%. The structural unit derived from the other monomer is preferably at most 15 mol%, more preferably at most 5 mol%. In the present specification, polyvinyl alcohol includes modified polyvinyl alcohol (modified PVA).

The modified PVA is preferably modified with a hydrophilic group.
The hydrophilic group is preferably at least one selected from the group consisting of a sulfonic acid group, a pyrrolidone ring group, a carboxylic acid group, and an amino group, for example. Of these, a sulfonic acid group and a pyrrolidone ring group are more preferable. The hydrophilic group includes a metal salt of a hydrophilic group in addition to the functional group described above. Examples of the metal salt include alkali metals such as sodium, potassium, and lithium.
The modified PVA modified with the hydrophilic group is obtained by copolymerizing unmodified polyvinyl alcohol and another monomer having the hydrophilic group, or adding a hydrophilic group to the unmodified polyvinyl alcohol. What is obtained by doing is included.

Examples of the modified PVA include sulfonic acid group-modified polyvinyl alcohol, pyrrolidone ring-modified polyvinyl alcohol, amino group-modified polyvinyl alcohol, and carboxyl group-modified polyvinyl alcohol.

The sulfonic acid group-modified polyvinyl alcohol is not particularly limited as long as the sulfonic acid group is introduced by modification, but the sulfonic acid group is bonded to the polymer main chain via a linking group. preferable.
Examples of the linking group include an amide group, an alkylene group, an ester group, and an ether group. Of these, a combination of an amide group and an alkylene group is preferable.
The sulfonic acid group is preferably a sulfonate salt, and particularly preferably a sodium sulfonate group.
In particular, when the modified PVA is sodium sulfonate-modified polyvinyl alcohol, the sodium sulfonate-modified polyvinyl alcohol preferably has a structural unit represented by the following formula (1).

In the above formula (1), ^{R 1} represents an alkylene group having 1 to 4 carbon atoms.

When the modified PVA is pyrrolidone ring-modified polyvinyl alcohol, the pyrrolidone ring-modified polyvinyl alcohol preferably has a structural unit represented by the following formula (2).

When the modified PVA is amino group-modified polyvinyl alcohol, the amino group-modified polyvinyl alcohol preferably has a structural unit represented by the following formula (3).

In the above formula (3), ^{R 2} represents a single bond or an alkylene group having 1 to 10 carbon atoms.

When the modified PVA is a carboxyl group-modified polyvinyl alcohol, the carboxyl group-modified polyvinyl alcohol has a structural unit represented by the following formula (4-1), (4-2) or (4-3). Is preferred.

In the above formulas (4-1), (4-2) and (4-3), X ¹ , X ² , X ³ , X ⁴ and X ⁵ are each independently a hydrogen atom, a metal atom or a methyl group. Represent. That is, in this specification, the carboxyl group contained in the structural unit having a carboxyl group includes a salt of the carboxyl group and a methyl ester. As a metal atom, a sodium atom etc. are mentioned, for example.
In the formula (4-2), ^{R 3} represents an alkylene group having 1 to 10 carbon atoms.

Examples of commercially available modified PVA include “KL-318”, “KL-118”, “KM-618”, and “KM-118” (all manufactured by Kuraray Co., Ltd.).

The content of the structural unit having a hydrophilic group in the modified PVA is preferably 0.1 mol%, more preferably 0.2 mol%, still more preferably 0.5 mol%, and particularly preferably 1 mol. The preferable upper limit is 15 mol%, the more preferable upper limit is 10 mol%, and the more preferable upper limit is 8 mol%. When the content of the structural unit having a hydrophilic group is not less than the above lower limit and not more than the above upper limit, the film may be discolored or broken over a long period of time against chlorine-containing sanitary agents or oxidizing chemicals. A film with no resistance can be obtained.

The saponification degree of the polyvinyl alcohol has a preferred lower limit of 80 mol%, a more preferred lower limit of 85 mol%, a still more preferred lower limit of 88 mol%, a particularly preferred lower limit of 90 mol%, and a more particularly preferred lower limit of 92 mol%. The preferred upper limit is 99.9 mol%, the more preferred upper limit is 99.0 mol%, the still more preferred upper limit is 98 mol%, the particularly preferred upper limit is 97 mol%, and the more particularly preferred upper limit is 96 mol%. When the saponification degree is not less than the above lower limit and not more than the above upper limit, it is easy to control the water resistance of the water-soluble packaging film and the dissolution time when the drug is released. From the viewpoint of improving both water resistance and control of dissolution time in a well-balanced manner, the saponification degree of the PVA is particularly preferably 85 mol% or more and 96 mol% or less.

The saponification degree is measured according to JIS K6726. The saponification degree indicates the proportion of units that are actually saponified to vinyl alcohol units among the units converted to vinyl alcohol units by saponification.
The method for adjusting the saponification degree is not particularly limited. The saponification degree can be appropriately adjusted according to saponification conditions, that is, hydrolysis conditions.

The PVA saponification degree distribution standard deviation (σ) has a preferable lower limit of 0.1 mol% and a preferable upper limit of 1.0 mol%.
When the saponification degree distribution standard deviation is not less than the above lower limit and not more than the above upper limit, the solubility of the water-soluble packaging film and the chemical resistance are improved, the dissolution time when the drug is released, and when the drug is packaged Both storage periods can be improved in a balanced manner.
The more preferable lower limit of the saponification degree distribution standard deviation of the PVA is 0.2 mol%, and the more preferable upper limit is 0.9 mol%.
The saponification degree distribution standard deviation is an index indicating the saponification degree variation in PVA, and can be measured and calculated using, for example, FT-IR.

The degree of polymerization of the PVA is not particularly limited. The preferable lower limit of the polymerization degree of the PVA is 400, the more preferable lower limit is 500, the still more preferable lower limit is 600, the particularly preferable lower limit is 900, the preferable upper limit is 2000, the more preferable upper limit is 1800, and the further preferable upper limit is 1500. When the polymerization degree is not less than the above lower limit and not more than the above upper limit, the viscosity of the aqueous solution becomes appropriate when a water-soluble packaging film is formed. When the degree of polymerization is not more than the above upper limit, the strength of the water-soluble packaging film is further increased and water resistance is obtained. The degree of polymerization is measured according to JIS K6726.

In the PVA, as a 4% by weight aqueous solution, the preferable lower limit of the viscosity measured at 20 ° C. is 3 mPa · s, the preferable upper limit is 35 mPa · s, the more preferable lower limit is 5 mPa · s, and the more preferable upper limit is 30 mPa · s. Water resistance can be improved by making the said viscosity into 3 mPa * s or more. By setting the viscosity to 35 mPa · s or less, the dissolution time can be shortened. The more preferable lower limit of the viscosity is 8 mPa · s, and the more preferable upper limit is 20 mPa · s.
The viscosity can be measured according to JIS K6726.

In 100% by weight of the water-soluble film, the preferable lower limit of the content of the polyvinyl alcohol is preferably 70% by weight, and the preferable upper limit is 97% by weight.
When the content of the polyvinyl alcohol is equal to or higher than the lower limit, bleeding out of the plasticizer from the water-soluble film can be suppressed, and a water-soluble film with better quality can be obtained. When the content of the polyvinyl alcohol is not more than the above upper limit, the strength of the water-soluble film is further increased, and the water resistance can be improved.

The water-soluble film preferably contains an alkali metal.
By containing the alkali metal, the dissolution time can be controlled while maintaining the water resistance of the water-soluble film.
In addition, if the said water-soluble film contains an alkali metal, the method to contain an alkali metal is not limited. Examples of the method of containing the alkali metal include a method of adding an alkali metal salt, a method of using polyvinyl alcohol containing an alkali metal, and the like. Examples of the polyvinyl alcohol containing an alkali metal include modified PVA modified with a hydrophilic group having an alkali metal salt.
For example, in the modification step, when using a modified PVA that uses a large amount of alkali metal, it is possible to contain the alkali metal by adding the modified PVA.

The content of the alkali metal in 100% by weight of the water-soluble film has a preferable lower limit of 1% by weight and a preferable upper limit of 5% by weight.
When the content of the alkali metal is 1% by weight or more, the dissolution time can be shortened. When the alkali metal content is 5% by weight or less, bleeding from the alkali metal water-soluble film can be suppressed and the appearance of the water-soluble film can be improved.
A more preferable lower limit of the alkali metal content is 1.5% by weight, and a more preferable upper limit is 4.5% by weight.
The amount of the alkali metal can be measured using, for example, an ICP emission analyzer.

The water-soluble film has a preferable lower limit of the alkali metal content per unit area of 0.06 g / m ² and a preferable upper limit of 10 g / m ² . When the alkali metal content per unit area is 0.06 g / m ² or more, an effect of shortening the dissolution time can be obtained, and when the alkali metal content is 10 g / m ² or less, the alkali metal is water-soluble packaging. Can be prevented from bleeding.
In addition, the alkali metal content per unit area means the weight of the alkali metal with respect to the area of the main surface of the water-soluble packaging film.
Such alkali metal content per unit area can be calculated from, for example, the amount of alkali metal measured using an ICP emission spectrometer and the area of the main surface of the water-soluble packaging film.

As the alkali metal, Li, Na, K, Rb, and Cs are used, and Na and K are particularly preferable. The alkali metal is preferably an alkali metal derived from an alkali metal salt. In addition, it may be derived from an alkali metal possessed by polyvinyl alcohol or a plasticizer.

Examples of the alkali metal salts include hydrides, halides, oxygen compounds, sulfides, oxyacid salts, and organic acid salts of the above alkali metals.
Examples of the organic acid constituting the organic acid salt include formic acid, acetic acid, lactic acid, succinic acid, gluconic acid, maleic acid, chloroacetic acid, oxalic acid, glycolic acid, tartaric acid, and citric acid.
Examples of the most common Na include halides such as NaF, NaCl, NaBr and NaI, oxygen compounds such as Na ₂ O, NaOH, Na ₂ O ₂ and NaO ₂ , Na ₂ S · nH ₂ O, NaHS · Sulfides such as nH ₂ O, chlorine compounds such as NaClO, NaClO ₂ , NaClO ₃ , NaClO ₄ , NaPH ₂ O ₂ , Na ₂ PHO ₃ , Na ₄ P ₂ O ₆ , Na ₂ H ₂ P ₂ O ₆ , Na Examples thereof include phosphorus compounds such as ₃ PO ₄ , organic acid salts such as NaHCO ₂ , NaCH ₃ CO ₂ , Na ₂ C ₂ O ₄ , Na ₂ C ₄ H ₄ O ₆ , and Na ₃ C ₆ H ₅ O ₇ . Of these, sodium formate (NaHCO ₂ ) and sodium acetate (NaCH ₃ CO ₂ ) are preferable. Moreover, you may use what replaced the said Na with alkali metals, such as K and Li.
In addition, the said alkali metal salt may be used independently and may use 2 or more types together.

As a molecular weight of the said alkali metal salt, a preferable minimum is 50 and a preferable upper limit is 140. When the molecular weight is less than 50, it may react violently with water and handleability may be poor, and when the molecular weight exceeds 140, the effect of shortening the dissolution time may not occur. The more preferable lower limit of the molecular weight is 60, and the more preferable upper limit is 100.

As for the addition amount of the alkali metal salt when adding the alkali metal salt, a preferable lower limit is 0.5 part by weight and a preferable upper limit is 15 parts by weight with respect to 100 parts by weight of polyvinyl alcohol. When the addition amount of the alkali metal salt is 0.5 parts by weight or more, the dissolution time can be shortened, and when it is 15 parts by weight or less, the alkali metal salt is prevented from bleeding from the water-soluble packaging film. be able to.

The water-soluble film preferably contains a plasticizer.
Water-soluble films are required to have high tensile strength and durability because they can be transported, stored, and used in hot and humid regions and cold regions. Particularly, impact resistance at low temperatures is important. When the water-soluble film contains a plasticizer, the glass transition point can be lowered, and durability at low temperatures can be improved. Moreover, the solubility with respect to the water of a water-soluble film can also be improved by containing the said plasticizer.

The plasticizer is not particularly limited as long as it is generally used as a plasticizer for PVA, and examples thereof include glycerin, diglycerin, diethylene glycol, trimethylolpropane, triethylene glycol, dipropylene glycol, and propylene glycol. Polyethylenes such as polyhydric alcohols, polyethylene glycol and polypropylene glycol, phenol derivatives such as bisphenol A and bisphenol S, amide compounds such as N-methylpyrrolidone, polyhydric alcohols such as glycerin, pentaerythritol and sorbitol Examples include added compounds and water. These may be used alone or in combination of two or more.
Among the above plasticizers, glycerin, trimethylolpropane, polyethylene glycol, polypropylene glycol, triethylene glycol, dipropylene glycol, and propylene glycol are preferable because water solubility can be improved, and the effect of improving water solubility is particularly large. Therefore, glycerin and trimethylolpropane are particularly preferable.

The content of the plasticizer in the water-soluble film is preferably 3 parts by weight with respect to 100 parts by weight of polyvinyl alcohol, and 15 parts by weight with respect to a preferred upper limit.
The water solubility of a water-soluble film can be improved as content of the said plasticizer is 3 weight part or more. Moreover, when the blending ratio of the plasticizer is 15 parts by weight or less, bleeding out of the plasticizer can be suppressed, and the anti-blocking property of the resulting water-soluble packaging film can be improved.
A more preferable lower limit of the plasticizer content is 4 parts by weight, and a more preferable upper limit is 13 parts by weight.

The water-soluble film preferably contains a saccharide.
The water-soluble film can improve water-solubility and flexibility by containing a saccharide, and can improve resistance to a chlorinating tablet.

As said saccharide | sugar, the thing similar to the saccharide | sugar which forms the said sugar coating layer can be used.

The content of the saccharide in the water-soluble film is such that a preferable lower limit with respect to 100 parts by weight of polyvinyl alcohol is 0.2 parts by weight, and a preferable upper limit is 12 parts by weight. More preferably, the lower limit is 0.5 parts by weight and the upper limit is 10 parts by weight, and still more preferably the lower limit is 1.5 parts by weight and the upper limit is 8 parts by weight.

The preferable upper limit of the thickness of the water-soluble film is 100 μm, the more preferable upper limit is 80 μm, and the still more preferable upper limit is 75 μm. The preferable lower limit of the thickness of the water-soluble film is 10 μm. The intensity | strength of the film which wraps a chemical | medical agent becomes still higher that the thickness of the said water-soluble packaging film is more than the said minimum. When the thickness of the water-soluble packaging film is not more than the above upper limit, the packaging property and heat-sealability as the water-soluble packaging film are further enhanced, the processing time is further shortened, and the productivity is further enhanced. Get higher.

The water-soluble film may further contain, as necessary, usual additives such as a colorant, a fragrance, an extender, an antifoaming agent, a release agent, an ultraviolet absorber, a surfactant, and starch. . In particular, in order to improve the releasability between the metal surface such as a die or drum of the film forming apparatus and the formed film or film stock solution, the ratio of 0.01 to 5 parts by weight of the surfactant with respect to 100 parts by weight of PVA It is preferable to mix with.

The water-soluble film preferably has a tensile strength of 5 to 30 MPa when a tensile test is performed at an elongation of 100%. If the tensile strength is less than 5 MPa, the strength of the film may be reduced during packaging of the drug, and the shape of the package may not be maintained. If the tensile strength exceeds 30 MPa, the dissolution time may be long. More preferably, it is 6 MPa or more, More preferably, it is 8 MPa or more, More preferably, it is 25 MPa or less, More preferably, it is 23 MPa or less.

Although it does not specifically limit as a manufacturing method of the said water-soluble film, The method of casting and drying the PVA aqueous solution containing PVA, a plasticizer, an alkali metal salt, and water to a support member can be used. Specific examples include a solution casting method (casting method), a roll coating method, a spin coating method, a screen coating method, a fountain coating method, a dipping method, and a spray method.

The PVA aqueous solution contains water together with the PVA and the plasticizer. The PVA is mainly dissolved in the water.

In the PVA aqueous solution, the content of the water is 300 parts by weight or more, preferably 400 parts by weight or more, more preferably 500 parts by weight or more with respect to 100 parts by weight of components other than water containing the PVA.
The water content is 900 parts by weight or less, preferably 800 parts by weight or less, more preferably 700 parts by weight or less. When the water content is not less than the above lower limit, the viscosity of the PVA aqueous solution becomes moderately low, and the casting of the PVA aqueous solution becomes easy. When the water content is not more than the above upper limit, the viscosity of the PVA aqueous solution becomes moderately high, the casting of the PVA aqueous solution becomes easy, the drying time is further shortened, the productivity is further increased, An even better quality water-soluble packaging film is obtained in which the orientation of the conductive packaging film is further enhanced.

It is preferable that the said support member can support the water-soluble packaging film obtained by maintaining the PVA aqueous solution on the surface during casting of the PVA aqueous solution. Examples of the material for the support member include polyolefin, polyester, acrylic resin, and the like. You may use the supporting member formed with materials other than these. Examples of the polyolefin include ethylene, polypropylene, ethylene-vinyl acetate copolymer, and ethylene-vinyl alcohol copolymer. Examples of the polyester include polyethylene terephthalate and polyethylene naphthalate. The material of the support member is preferably not PVA.

The drying method after casting the PVA aqueous solution on the support member can be any suitable method and is not particularly limited. Examples of the drying method include a method of natural drying and a method of heat drying at a temperature lower than the glass transition temperature of PVA.

The water-soluble packaging film may be a laminated film including a support member and a water-soluble packaging film laminated on the support member. The laminated film can be obtained by casting the PVA aqueous solution described above and drying it. Thus, the said water-soluble film may be provided in the state laminated | stacked on the support member.

The method for producing the chlorinated tablet package is not particularly limited. For example, the PVA aqueous solution is poured on the coated chlorinated tablet of the present invention and then dried, and a water-soluble packaging film is laminated on the coated chlorinated tablet. And a method for producing a package containing the coated chlorine agent tablet by putting the coated chlorine agent tablet of the present invention into a bag made of a water-soluble packaging film.

According to the present invention, it is possible to improve the handleability of the chlorine agent and maintain sufficient water solubility even when stored for a long period of time. It is possible to provide a coated chlorine agent tablet that can further improve the effect and can suppress a decrease in water solubility of the water-soluble film. Furthermore, it is possible to provide a chlorinated tablet package in which the coated chlorinated tablet is packaged with a water-soluble film.

Examples of the present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

Example 1
(Chlorine tablets)
1% by weight boric acid is added to trichloroisocyanuric acid (manufactured by Tokyo Kasei Kogyo Co., Ltd., grade EP), filled in a mold, and pressed using a press machine, 30 mm in diameter, 12 mm in thickness, 15 in weight. .3 g of chlorinated tablets were obtained.

(Formation of sugar coating layer)
50 g of glucose (specific gravity 1.54 g / cm ³ , melting point 146 ° C., molecular weight 180) and 50 g sucrose (specific gravity 1.587 g / cm ³ , melting point 186 ° C., molecular weight 342) are mixed with 50 g of water and heated with stirring. An aqueous solution was prepared. Further, the aqueous solution was gradually heated to evaporate the moisture, and finally heated to 145 ° C. to prepare a coating solution.
After cooling the obtained coating solution to 100 ° C. and immersing the chlorinated tablets, the chlorinated tablets are taken out on a Teflon (registered trademark) sheet and cooled to room temperature to form a sugar coating layer (thickness: 1.5 mm). 21.6 g of a coated chlorine agent tablet having the same was produced.
The thickness of the sugar coating layer was calculated by calculating the specific gravity of the saccharide contained in the coating liquid from the blending amount and specific gravity of the raw material, and further by the following formula.
Sugar coating thickness (mm) = [(weight of coated chlorine tablet-weight of chlorine tablet) (g) / (specific gravity of sugar) (g / cm ³ )] / (surface area of chlorine tablet) ( cm ² )

(Example 2)
A coated chlorine tablet was prepared in the same manner as in Example 1 except that 100 g of sucrose was used to prepare a coating solution.

(Example 3)
(Production of water-soluble film)
100 parts by weight of polyvinyl alcohol (polymerization degree 1300, saponification degree 88.0 mol%, 4 wt% aqueous solution viscosity 14 mPa · s, saponification degree distribution standard deviation 0.18 mol%), glycerin as plasticizer (Wako Pure Chemical Industries, Ltd.) 10 parts by weight and 2 parts by weight of glucose were dissolved in 450 parts by weight of water to prepare an aqueous PVA solution.

The standard deviation of saponification degree distribution of the polyvinyl alcohol was measured by the following procedure.
(Saponification degree distribution standard deviation measurement)
Forty particles were randomly selected from the polyvinyl alcohol particles, and the amount of acetyl groups of the polyvinyl alcohol was measured using ATR-specific FT-IR (manufactured by Shimadzu Corporation, IRAffinity-1). The saponification degree of each particle was obtained from the obtained acetyl group amount, and the standard deviation (σ) of the saponification degree distribution was calculated from the variation in the saponification degree.

The obtained PVA aqueous solution was applied onto a polyethylene terephthalate (PET) film (thickness 50 μm) as a support member using an auto film applicator (PI-1210, manufactured by Tester Sangyo Co., Ltd.) and dried at 80 ° C. for 5 minutes. Then, drying was performed at 100 ° C. for 20 minutes to obtain a laminated film in which a PVA film (thickness 50 μm) was laminated on the support member.
The support member was peeled off from the obtained laminated film to obtain a water-soluble film.

(Production of chlorinated tablet packaging)
The obtained water-soluble film was folded in two and the end was heat sealed to produce a 6 cm × 12 cm bag with one end open. The coated chlorine agent tablet obtained in Example 1 was put in this bag, and the open end was heat-sealed to obtain a chlorine agent tablet package having a coated chlorine agent tablet inside.

Example 4
A chlorinated tablet package was obtained in the same manner as in Example 3 except that the coated chlorinated tablet obtained in Example 2 was used.

(Example 5)
(Production of water-soluble film)
Pyrrolidone ring-modified polyvinyl alcohol having a structural unit represented by the above formula (2) as polyvinyl alcohol (polymerization degree 1000, saponification degree 95.8 mol%, pyrrolidone ring modification amount 4 mol%, 4 wt% aqueous solution viscosity 10 mPa · s, 100 parts by weight of saponification degree distribution standard deviation 0.21 mol%), 10 parts by weight of glycerin (manufactured by Wako Pure Chemical Industries, Ltd.) as a plasticizer, and 2 parts by weight of glucose are dissolved in 450 parts by weight of water to obtain PVA. An aqueous solution was prepared.
A water-soluble film was obtained in the same manner as in Example 3 except that the obtained PVA aqueous solution was used.

(Production of chlorinated tablet packaging)
The obtained water-soluble film was folded in two and the end was heat sealed to produce a 6 cm × 12 cm bag with one end open. The coated chlorine agent tablet obtained in Example 2 was put in this bag, and the open end was heat-sealed to obtain a chlorine agent tablet package having a coated chlorine agent tablet inside.

(Example 6)
(Production of water-soluble film)
Pyrrolidone ring-modified polyvinyl alcohol having a structural unit represented by the above formula (2) as polyvinyl alcohol (polymerization degree 1000, saponification degree 95.8 mol%, pyrrolidone ring modification amount 4 mol%, 4 wt% aqueous solution viscosity 10 mPa · s, saponification degree distribution standard deviation 0.21 mol%) 100 parts by weight, glycerin (manufactured by Wako Pure Chemical Industries, Ltd.) 10 parts by weight, trisodium citrate (manufactured by Kishida Chemical Co., Ltd.) 3 parts by weight, and Then, 2 parts by weight of glucose was dissolved in 450 parts by weight of water to prepare a PVA aqueous solution.
A water-soluble film was obtained in the same manner as in Example 3 except that the obtained PVA aqueous solution was used.

(Production of chlorinated tablet packaging)
The obtained water-soluble film was folded in two and the end was heat-sealed to produce a 5 cm × 4 cm bag with one end open. The coated chlorine agent tablet obtained in Example 2 was put in this bag, and the open end was heat-sealed to obtain a chlorine agent tablet package having a coated chlorine agent tablet inside.

(Example 7)
A coated chlorine tablet was prepared in the same manner as in Example 2 except that the thickness of the sugar coating layer was 3 mm.
A chlorinated tablet package was obtained in the same manner as in Example 6 except that the obtained coated chlorinated tablet was used.

(Example 8)
A coated chlorine agent tablet was produced in the same manner as in Example 2 except that the thickness of the sugar coating layer was 0.5 mm.
A chlorinated tablet package was obtained in the same manner as in Example 6 except that the obtained coated chlorinated tablet was used.

(Comparative Example 1)
Chlorine tablets were prepared in the same manner as in Example 1 except that the sugar coating layer was not formed.

(Comparative Example 2)
A chlorinated tablet package was obtained in the same manner as in Example 3 except that the chlorinated tablet obtained in Comparative Example 1 was used.

(Comparative Example 3)
A chlorinated tablet package was obtained in the same manner as in Example 6 except that the chlorinated tablet obtained in Comparative Example 1 was used.

(Evaluation)
(1) Odor Evaluation Coated chlorine tablet obtained in Examples 1 and 2, chlorine agent tablet package obtained in Examples 3 to 8, chlorine tablet obtained in Comparative Example 1, Comparative Examples 2 and 3 The chlorinated tablet package obtained in the above was allowed to stand for 15 hours in an environment of 20 ° C. and 50% RH, and after sufficiently absorbing water, a PTFE inner cylinder sealed container (manufactured by Sansho Co., Ltd., metal valve for SR-50) A sample was prepared by sealing in a). This sample was left in an oven at 60 ° C. for 1 week.
After standing for 1 week, the strength of chlorine odor when the container was opened was evaluated according to the following criteria.
◯: Some odor was generated.
Δ: It was difficult for the odor to approach strongly.
X: The odor was intense and the back of the nose and the throat felt uncomfortable.

(2) A sample was prepared in the same manner as the evaluation of sticky odor, and left in an oven at 60 ° C. for 1 week.
After standing for 1 week, the coated chlorine tablet, the chlorine tablet package and the chlorine tablet were taken out using rubber gloves and evaluated according to the following criteria.
○: There was no deposit on the rubber gloves and there was no problem in handling.
Δ: Slight deposits on rubber gloves, but no problem in handling.
X: There were a large amount of deposits on the bottom of the rubber gloves and the container, and handling was difficult.

(3) A sample was prepared in the same manner as in the evaluation of water-soluble odor, and left in an oven at 60 ° C. for 1 week.
After leaving for one week, the coated chlorine tablet, the chlorine tablet package, and the chlorine tablet were taken out.
About Examples 3-8, the part which contact | coated the covering chlorine agent tablet of the water-soluble film which comprises a chlorine agent tablet packaging body was cut into the size of 3 mm x 1.5 mm, and 3 mm was similarly done about the other surface. It cut | disconnected to the size of * 1.5mm, and took out two test pieces.
For Comparative Examples 2 and 3, the portion of the water-soluble film constituting the chlorinated tablet packaging that was in contact with the chlorinated tablet was cut into a size of 3 mm × 1.5 mm, and the other side was similarly formed. Cut to a size of 3 mm × 1.5 mm, two test pieces were taken out.
The obtained two test pieces were weighed, put into a 20 ml polyethylene container, 12 ml of water was further added, and the mixture was stirred at a stirring speed of 180 rpm for 10 minutes.
Thereafter, the obtained aqueous solution was filtered through a 200-mesh stainless mesh whose weight was previously measured to separate undissolved gel components. The mesh was dried at 80 ° C. for 1 hour, and further allowed to stand in an environment of 23 ° C. and 50% RH for 15 hours.
Thereafter, the weight of the mesh was measured, and the dissolution rate of the water-soluble film was calculated from the change in weight.

Moreover, about Examples 1-8, the sugar-coating layer was isolate | separated, the sugar-coating layer 1g and water 15g which were isolate | separated into the test tube were thrown in, it mixed for 10 minutes, the external appearance was observed visually, and the following references | standards evaluated. .
A: Almost completely dissolved.
Δ: About 30% remained undissolved.
X: 50% or more remained undissolved.

Moreover, comprehensive evaluation of water solubility was performed according to the following criteria. In addition, about Example 1, 2 and the comparative example 1, since there was no water-soluble film and there was no undissolved film, it evaluated as "(circle)".
A: There was almost no undissolved residue of the sugar coating layer, and the solubility of the water-soluble film was 80% by weight or more.
Δ: There was almost no undissolved residue of the sugar coating layer, and the solubility of the water-soluble film was 60% by weight or more and less than 80% by weight.
X: The sugar-coating layer remained undissolved or the sugar-coating layer was hardly undissolved, and the solubility of the water-soluble film was less than 60% by weight.

According to the present invention, it is possible to improve the handleability of the chlorine agent and maintain sufficient water solubility even when stored for a long period of time. It is possible to provide a coated chlorine agent tablet that can further improve the effect and can suppress a decrease in water solubility of the water-soluble film. Moreover, the chlorine-containing tablet packaging body in which the coated chlorine-containing tablet is packaged with a water-soluble film can be provided.

Claims (9)

A coated chlorinated tablet having a sugar coating layer on the surface of the chlorinated tablet,
The chlorinated tablet contains a chlorine-containing compound,
The sugar-coating layer contains 30% by weight or more of sugar and is a coated chlorine tablet. The chlorinated tablet according to claim 1, wherein the saccharide is a saccharide. The coated chlorinating tablet according to claim 2, wherein the monosaccharide unit constituting the saccharide has two or more hydroxyl groups. The coated chlorine agent tablet according to claim 1, 2 or 3, wherein the sugar has a molecular weight of 1000 or less. The coated chlorine agent tablet according to claim 1, 2, 3, or 4, wherein the sugar has a melting point of 30 ° C or higher. The coated chlorine agent tablet according to claim 1, 2, 3, 4 or 5, wherein the sugar coating layer has a thickness of 0.01 to 5 mm. A chlorinated tablet packaging product, wherein the coated chlorinated tablet according to claim 1, 2, 3, 4, 5, or 6 is packaged with a water-soluble film. The chlorinated tablet packaging body according to claim 7, wherein the water-soluble film contains polyvinyl alcohol. The chlorine-containing tablet packaging according to claim 7 or 8, wherein the water-soluble film contains 1% by weight or more of an alkali metal.