JP2018145162A - Dentifrice composition - Google Patents

Abstract

An object of the present invention is to provide a dentifrice composition excellent in a feeling of massage effect and a real feeling of dirt removal by brushing. A dentifrice composition comprising (A) tranexamic acid, (B) acyl glutamate, and (C) water-insoluble granules having an average particle size of 100 to 300 µm. Further, (D) the above dentifrice composition containing 2 to 200 units / g of dextranase. [Selection diagram] None

Description

  The present invention relates to a dentifrice composition containing water-insoluble granules and excellent in the massage effect and the feeling of removing dirt by brushing teeth.

  In a dentifrice composition, it is effective for making toothbrushing habits and expressing its effects to increase the added value by giving a feeling of massage effect of gums and a feeling of dirt removal after brushing. The feeling of massaging your gums by brushing your teeth is good when you brush your teeth (when brushing) and when you feel good after tightening your teeth (after brushing your mouth and rinsing your mouth). It is desirable because it is recognized. Moreover, as a feeling of stain removal after brushing, it is desirable that not only the smoothness of the tooth surface but also the cleaning feeling between the teeth (tooth gap) is recognized as an excellent feeling of stain removal. Improvement of the actual feeling of these effects is an important issue in order to raise the satisfaction of toothpaste users.

Various techniques have been proposed so far in which specific particles, water-insoluble granules, and the like are blended into the dentifrice composition to improve the massage effect by brushing.
Patent Document 1 (Japanese Patent Laid-Open No. 10-152424) discloses an oral composition having an excellent massage effect and a high blood flow promoting effect with granular salt having an average particle diameter of 700 to 1400 μm. There is a problem in terms of taste limitation and irritation because large salt is used. Patent Document 2 (Japanese Patent Application Laid-Open No. 2007-70256) discloses a toothpaste composition that provides a feeling of tightening and massaging gums by blending granular erythritol having a particle size of 355 μm or more and less than 855 μm instead of salt. However, there is a problem in terms of irritation due to the large particle size of granular erythritol.
Patent Document 3 (Japanese Patent Application Laid-Open No. 2015-124150) discloses a feeling of massage effect when brushing teeth (feeling with gums) by using a water-insoluble colored granule containing a specific pigment and a warming agent such as spirantol. A dentifrice composition excellent in a pleasant sensation of stimulation) and a feeling of warmth has been proposed, and specifically, colored granules having an average particle size of 200 to 500 nm are used.
Patent Document 4 (International Publication No. 2006/3989) describes heavy calcium carbonate having an average particle size of 5 to 15 μm, a disintegration strength of 10 to 200 g / piece, an average particle size of 50 to 150 μm, and a 90% particle size. By combining a water-insoluble inorganic granule having a difference between the average particle size of 100 μm or less and two or more specific water-soluble polymer substances in combination, the feeling of brushing with granules can be improved with an appropriate polishing force. Dentifrice compositions have been proposed.
Patent Document 5 (Japanese Patent Laid-Open No. 2006-98211) contains granules having an average particle size of 100 to 300 μm, a specific disintegration strength and a deformation rate, and has high ability to remove dental plaque and dirt between teeth. Dentifrices have been proposed.

Japanese Patent Laid-Open No. 10-152424 JP 2007-70256 A JP2015-124150A International Publication No. 2006/3989 Japanese Patent Laid-Open No. 2006-98211

  However, in the conventional technology, in the dentifrice composition, the massage effect feeling of gums by brushing and the feeling of stain removal after brushing could not be sufficiently obtained, and both effects could not be given simultaneously and satisfactorily.

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition containing water-insoluble granules and having an excellent massage effect and a feeling of dirt removal by brushing.

  As a result of intensive studies to achieve the above object, the present inventors have formulated tranexamic acid in combination with a specific anionic surfactant and a water-insoluble granule having a specific average particle size, thereby providing a massage effect by brushing teeth. The present inventors have found that a dentifrice composition excellent in feeling (granule contact feeling and squeezing feeling of gums) and a feeling of dirt removal (a feeling of dirt removal at the interdental part) can be obtained.

Even if a water-insoluble granule is added to a dentifrice composition together with a surfactant such as an anionic surfactant that is generally used for the purpose of foaming, cleaning, etc., a satisfactory massage effect and a feeling of stain removal can be achieved by brushing teeth. In the present invention, the combination of (A) tranexamic acid, (B) acyl glutamate, and (C) water-insoluble granules having an average particle size of 100 to 300 μm is combined to brush the teeth. Both the massage effect feeling and the feeling of dirt removal are improved, and both the excellent massage effect feeling and the feeling of dirt removal are compatible. According to the present invention, both the feeling of granule contact (a comfortable and moderate irritation feeling) and a feeling of squeezing on the gums due to tooth brushing are enhanced, giving a comfortable and satisfying massage feeling, and a feeling of dirt removal in the interdental region that is difficult to clean As a result of the increase, it is possible to give a satisfactory feeling of dirt removal even in the interdental part, and to give a feeling of excellent effect.
Such operational effects of the present invention are unique to the combination of the components (A), (B) and (C), and if any of the three components is lacking, the massage effect or the feeling of removing dirt is inferior. The object of the invention is not achieved. As shown in a comparative example described later, when the component (A) is not included, the feeling of tightening the gums is inferior and the massage effect is low even if the components (B) and (C) are included. Further, if the component (B) is not included, even if the components (A) and (C) are included, and the anionic surfactant sodium lauryl sulfate or lauroyl sarcosine sodium is included, the gum feel is inferior, and massage The effect is low. When component (C) is not included, component (A) and component (B) are included, and even if water-insoluble granules having an average particle size of 40 μm or 500 μm are included, the feeling of granule contact in the gums or the feeling of stain removal at the interdental part Is inferior, and the massage effect and the feeling of removing dirt are not compatible.

Accordingly, the present invention provides the following dentifrice composition.
[1]
(A) tranexamic acid,
A dentifrice composition comprising (B) an acyl glutamate and (C) water-insoluble granules having an average particle size of 100 to 300 μm.
[2]
The dentifrice composition according to [1], wherein the acyl glutamate has 8 to 20 carbon atoms in the acyl group.
[3]
The dentifrice composition according to [1] or [2], wherein the water-insoluble granules are particles in which at least one water-insoluble material selected from silica, zeolite, calcium phosphate, calcium carbonate and aluminum hydroxide is formed into granules. .
[4]
(A) 0.01-0.2 mass% of component, (B) component 0.1-0.8 mass%, (C) 1-5 mass% of component is contained [1]-[3] The dentifrice composition in any one.
[5]
The dentifrice composition according to any one of [1] to [4], wherein (C) / (B) is 1 to 50 in terms of mass ratio.
[6]
The dentifrice composition according to any one of [1] to [5], further comprising (D) 2 to 200 units / g of dextranase.
[7]
Furthermore, the dentifrice composition in any one of [1]-[7] which is a toothpaste containing the abrasive | polishing agent with an average particle diameter of 5-40 micrometers.

  ADVANTAGE OF THE INVENTION According to this invention, the dentifrice composition containing a water-insoluble granule which is excellent in the massage effect feeling by a toothbrushing and the feeling of dirt removal can be provided.

  The present invention will be described in further detail below. The dentifrice composition of the present invention is characterized by containing (A) tranexamic acid, (B) acyl glutamate, and (C) water-insoluble granules having an average particle size of 100 to 300 μm.

(A) As tranexamic acid, tranexamic acid conforming to the Japanese Pharmacopoeia can be used. Specifically, commercially available products such as those manufactured by Kyowa Pharma Chemical Co., Ltd. can be used.
The blending amount of (A) tranexamic acid is preferably 0.01 to 0.2% (mass%, the same applies hereinafter) of the whole composition, more preferably 0.01 to 0.1%, still more preferably 0.05. ~ 0.1%. When it is 0.01% or more, a feeling of tightness of the gums is sufficiently obtained, and the feeling of massage effect is improved. If it is 0.2% or less, coloring during storage is prevented and the appearance of the preparation is sufficiently stabilized.

(B) The acyl glutamate may be an N-acyl glutamate having an acyl group with carbon number of preferably 8 to 20, more preferably 12 to 16, and the salt thereof is an alkali metal salt such as sodium salt. Is preferred.
Examples thereof include sodium lauroyl glutamate, sodium myristoyl glutamate, sodium cocoyl glutamate, sodium stearoyl glutamate, and the like. Among these, sodium N-lauroyl glutamate is preferable.
Specifically, a commercially available aminosurfact ALMS-P1 (manufactured by Asahi Kasei Finechem Co., Ltd.) and the like can be used.

  (B) The amount of acyl glutamate is preferably 0.1 to 0.8% of the total composition, more preferably 0.3 to 0.8%, still more preferably 0.3 to 0.6%. is there. When it is 0.1% or more, a feeling of tightness of the gums and a feeling of stain removal at the interdental part are sufficiently obtained. When the content is 0.8% or less, the feeling of granule contact with the gums can be satisfactorily maintained.

(C) The water-insoluble granules have an average particle size of 100 to 300 μm, preferably 150 to 300 μm, more preferably 150 to 200 μm. When the average particle size is less than 100 μm, the feeling of granule contact with the gums is inferior.
The average particle size was measured using a particle size distribution measuring device (manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution meter, dispersion medium; water), and the measured value was calculated as a volume-based median diameter (d50).

The water-insoluble granules are preferably disintegrant granules having a disintegration strength of 10 to 200 g / piece, particularly 10 to 50 g / piece. If it is less than 10 g / piece, it may disintegrate instantaneously when starting brushing, so that an excellent massage effect may not be obtained. If it exceeds 200 g / piece, discomfort may occur in the oral cavity.
The average disintegration strength is the value obtained by measuring the automatic breaking strength of 30 granules with a rheometer (Sun Rheometer CR-200D) manufactured by Sun Science Co., Ltd. (this granule disintegrates when one granule is compressed at a speed of 10 mm / min). The value obtained by measuring the load at the time of measurement) was obtained from the average value.

Water-insoluble granules are particles in which a water-insoluble material is formed into a granule. Known methods such as a method of pulverizing a water-insoluble inorganic coagulum, water is added to a water-insoluble inorganic powder to form a slurry, and pressure is applied. Can be produced by granulating and drying. Other production methods include compression molding methods, extrusion molding methods, spray drying methods, sintering methods, and the like, and the water-insoluble granules blended in the present invention are used regardless of the method produced. it can. In addition, you may manufacture by adding generally used excipient | filler etc. as needed.
Examples of the water-insoluble material include inorganic powders such as silica, zeolite, calcium phosphate, calcium carbonate, and aluminum hydroxide. These may be used alone or as a mixture of two or more. In particular, silica granules are preferable as the water-insoluble granules in terms of brushing feeling and toothpaste dispersibility.
Commercially available products can be used as such water-insoluble granules, and specific examples include NIPGEL (manufactured by Tosoh Silica Co., Ltd.).

  (C) As for the compounding quantity of a water-insoluble granule, 1 to 5% of the whole composition is preferable, More preferably, it is 1 to 4%, More preferably, it is 2 to 4%. When it is 1% or more, a feeling of tightening the gums and a feeling of stain removal at the interdental part can be sufficiently obtained. If it is 5% or less, the rinsing property can be maintained well, and the residual feeling at the time of rinsing can be prevented.

  Furthermore, (C) / (B) which shows the mixture ratio of the (C) component with respect to the (B) component is preferably 1 to 50, more preferably 2 to 35, and still more preferably 5 to 12 as a mass ratio. Within this range, the feeling of granule contact with the gums, the feeling of tightening of the gums, and the feeling of stain removal at the interdental part are further improved. If it is less than 1, the feeling of granule contact with the gums may be inferior, and if it exceeds 50, the feeling of tightness of the gums or the feeling of stain removal between the teeth may be inferior.

The dentifrice composition of the present invention preferably further contains (D) dextranase as an enzyme. When (D) component is mix | blended, the stain | pollution | contamination actual feeling of an interdental part will increase more.
Examples of dextranase include dextranases obtained by known methods from known dextranase-producing bacteria belonging to the genus Ketomium, Penicillium, Aspergillus, Spicaria, Lactobacillus, Servibrio, etc. Dextranase produced from microorganisms can also be used. Specifically, Mitsubishi Chemical Foods Co., Ltd. can be used as a commercial product.

(D) The blending amount of dextranase is preferably 2 to 200 units / g (U / g), particularly 10 to 50 units / g in the composition. If it is less than 2 units / g, the actual feeling of dirt removal between the teeth may not be sufficiently improved. If it exceeds 200 units / g, the stability may not be sufficient.
Here, 1 unit of dextranase is the amount of dextranase that produces free reducing sugar corresponding to 1 μmol of glucose per minute when the reaction is carried out using dextran as a substrate.
When 13,000 units / g of dextranase is usually used, the amount of dextranase is 0.0154 to 1.54% of the total composition.

  The dentifrice composition of the present invention can be prepared as a toothpaste, particularly as a toothpaste, a liquid dentifrice, a toothpaste. Moreover, in addition to the said component, the well-known component according to a dosage form etc. can be added in the range which does not prevent the effect of this invention. For example, surfactants other than the component (B), abrasives, binders, thickeners, and optionally sweeteners, preservatives, colorants, fragrances, and components other than the components (A) and (D) are effective. Ingredients are blended.

Examples of the surfactant include an anionic surfactant other than the component (B), an amphoteric surfactant, and a nonionic surfactant.
Examples of the anionic surfactant include lauryl sulfate, myristyl sulfate, polyoxyethylene alkyl sulfate, and the like. The salt is preferably a sodium salt from the viewpoint of solubility.
Examples of amphoteric surfactants include 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolium betaine, fatty acid amidopropyl betaine, etc., and those having a fatty acid chain length of 12 to 14 carbon atoms are soluble. Is preferable.
Nonionic surfactants include polyoxyethylene alkyl ether, alkyl glycoside, sucrose fatty acid ester, alkylol amide, polyoxyethylene polyoxypropylene glycol, fatty acid polyglyceryl, polyoxyethylene hydrogenated castor oil, and the like.
The total amount of these surfactants is 0 to 3%, particularly 0.1 to 3%. The blending amount of the anionic surfactant other than the component (B) is 1% or less, particularly 0.5% or less, particularly 0.3% or less, and may be 0% without blending. The blending amounts of the amphoteric surfactant and the nonionic surfactant may be 3% or less, particularly 1% or less, respectively, or may not be blended.

As a polishing agent, a general polishing agent for dentifrice can be used. For example, silica-based abrasives such as silica gel, precipitated silica and aluminosilicate, dicalcium phosphate dihydrate and anhydrous, tertiary calcium phosphate, tertiary magnesium phosphate, tetracalcium phosphate, calcium pyrophosphate, etc. , Calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, zirconium silicate, hydroxyapatite, synthetic resin-based abrasive and the like. Among these, silica-based abrasives are preferable, and abrasive silica different from the silica granules described above can be used.
The average particle diameter of the abrasive, particularly abrasive silica, is preferably 5 to 40 μm, particularly 10 to 30 μm, in terms of volume-based median diameter (d50). The median diameter is a value measured using a particle size distribution measuring device (manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution meter, dispersion medium: water).
The blending amount of the abrasive is usually 0 to 50%, particularly 2 to 40% of the whole composition. Generally, the blending amount in the toothpaste is 10 to 50%, and the blending amount in the liquid toothpaste is 0 to 30%.

  Examples of the thickener include sugar alcohols such as sorbit and xylit, and polyhydric alcohols such as glycerin and propylene glycol. These compounding amounts are usually 5 to 50%, particularly 20 to 45%.

  Examples of the binder include xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, carrageenan, guar gum, sodium alginate, cationized cellulose, thickened silica, montmorillonite, gelatin, and sodium polyacrylate. These can be used alone or in combination of two or more. The amount of the binder is usually 0.3 to 5%.

Examples of the sweetener include saccharin sodium and the like, and examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.
Examples of the colorant include blue No. 1, yellow No. 4, titanium dioxide and the like.

  Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, bran oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumes, etc.) and menthol, Rubon, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-1-Mentoxypropane-1,2-diol, Thymol, Linalol, Linarel acetate, Limonene, Menthone, Menthyl acetate, N-Substituted paramenthane 3-carboxamide, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, Hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, ethyl Single-flavored ingredients such as o-acetate, as well as fragrances such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, etc. Known perfume materials can be used.

  Active ingredients include fluorides such as sodium fluoride and sodium monofluorophosphate, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphoric acid, mutanase, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride Glycyrrhizic acid and its salts, sodium chloride, epsilon aminocaproic acid, dl-tocophenol acetate, α-bisabolol, isopropylmethylphenol, chlorohexidine salts, cetylpyridinium chloride, azulene, glycyrrhetinic acid, copper chlorophyllin sodium, copper gluconate, etc. Copper compounds, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, amylase, methoxy Ethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, and moreover, soft extract of sugar beet, duckweed extract, clove, rosemary, ugone, safflower And the like. In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.
Moreover, the detail of the silica granule C1-C6 used in each case is shown below.
Silica granule; manufactured by Tosoh Silica Co., Ltd., trade name: NIPGEL
Average disintegration strength 10-50 g / piece Silica granule C1:
The AY grade was classified using a sieve A (aperture: 180 μm) having an inner diameter of 20 cm and a sieve B (aperture: 212 μm) to obtain granules C1 having an average particle diameter of 200 μm.
Silica granule C2:
AY grade is sieve A (mesh size: 90 μm) and sieve B (mesh size: 106 μm) with an inner diameter of 20 cm.
m) to obtain granules C2 having an average particle size of 100 μm.
Silica granule C3:
AY grade is sieve A (opening: 125 μm) with an inner diameter of 20 cm, sieve B (opening: 180)
μm) to obtain granules C3 having an average particle size of 150 μm.
Silica granule C4:
AY grade is sieve A (opening: 250 μm) with an inner diameter of 20 cm, sieve B (opening: 355)
to give granules C4 having an average particle size of 300 μm.
Silica granule C5: (Comparative product)
The AY grade was classified using a sieve A (aperture: 38 μm) having an inner diameter of 20 cm and a sieve B (aperture: 45 μm) to obtain granules C5 having an average particle diameter of 40 μm.
Silica granule C6: (Comparative product)
AY grade is sieve A (aperture: 425 μm) with an inner diameter of 20 cm, sieve B (aperture: 600)
to give granules C6 having an average particle diameter of 500 μm.
As the abrasive silica, silicic acid anhydride having an average particle diameter of 18 μm manufactured by Taki Chemical Co., Ltd. was used.
The average particle size was measured using a particle size distribution measuring device (manufactured by Nikkiso Co., Ltd., Microtrac particle size distribution meter, dispersion medium; water), and the measured value was calculated as a volume-based median diameter (d50). The average disintegration strength is determined by measuring the automatic breaking strength of 30 granules with a rheometer (Sun Rheometer CR-200D) manufactured by Sun Science Co., Ltd. (when the granule disintegrates when one granule is compressed at a speed of 10 mm / min). The value obtained by measuring the load of.

[Examples and Comparative Examples]
Dentifrice compositions (toothpaste) having the compositions shown in Tables 1 and 2 were prepared by a conventional method and evaluated by the following methods. The results are shown in the table.

(1) Evaluation method of massage effect feeling (gum granule contact feeling) at the time of tooth brushing The test was performed on 10 subjects. About the granule contact feeling (comfortable and moderate irritation) felt by the gums while pushing out the prepared dentifrice composition from a tube container, placing it on a toothbrush about 1 cm (about 1 g) and brushing the teeth as usual, Judgment was made based on the following criteria. An average score of 10 judgment points was calculated and evaluated according to the following evaluation criteria.
When the evaluation was B or higher, a moderate massage stimulus was obtained and the granule contact feeling was acceptable.
Rating criteria 5: Feeling of granular contact with the gums 4: Feeling of granular contact with the gums 3: Feeling of granular contact with the gums 2: Not feeling of granular contact with the gums 1: Feeling of granular contact with the gums Evaluation standard A: Average value is 4.0 points or more and 5.0 points or less B: Average value is 3.0 points or more and less than 4.0 points C: Average value is 2.0 points or more and less than 3.0 points D: Average value is less than 2.0 points

(2) Evaluation method of feeling of massage effect after tooth brushing (feeling of tightening gums) The test was conducted on 10 subjects. The prepared dentifrice composition was extruded from a tube container, placed on a toothbrush about 1 cm (about 1 g) and brushed for 3 minutes in the same manner as usual, and the feeling of tightening the gums was determined based on the following criteria. An average score of 10 judgment points was calculated and evaluated according to the following evaluation criteria.
When the evaluation was B or higher, it was determined that a moderate massage feeling was obtained and the feeling was good.
Rating criteria 5: Feeling the gums tight 4: Feeling the gums tight 3: Feeling the gums slightly feel 2: Do not feel the gums tight 1: Do not feel the gum tightness Evaluation criteria A: The average value is 4.0 points or more and 5.0 points or less B: The average value is 3.0 points or more and less than 4.0 points C: The average value is 2.0 points or more and less than 3.0 points D: The average value is Less than 2.0

(3) Evaluation method of the feeling of stain removal at the interdental portion The test was conducted on 10 subjects. The prepared dentifrice composition was extruded from a tube container, placed on a toothbrush about 1 cm (about 1 g), and after brushing for 3 minutes in the same way as usual, the actual feeling of stain removal between the teeth was judged based on the following criteria. did. An average score of 10 judgment points was calculated and evaluated according to the following evaluation criteria.
In addition, the feeling that the air passes between the teeth when inhaling (feeling of interdental cleanliness) was the actual feeling of stain removal at the interdental part.
When the evaluation was B or more, the feeling of stain removal at the interdental part was considered good.
Rating criteria 5: Very clean feeling of interdental area 4: Feeling of cleanliness of interdental area 3: Feeling of cleanliness of interdental area slightly 2: Feeling of cleanliness of interdental area slightly 1: Evaluation criteria S: Average point is 4.5 points or more and 5.0 points or less A: Average point is 4.0 points or more and less than 4.5 points B: Average point is 3.0 points Or more and less than 4.0 points C: average point is 2.0 points or more and less than 3.0 points D: average point is less than 2.0 points

Claims (7)

(A) tranexamic acid,
A dentifrice composition comprising (B) an acyl glutamate and (C) water-insoluble granules having an average particle size of 100 to 300 μm.   The dentifrice composition according to claim 1, wherein the acyl glutamate has 8 to 20 carbon atoms in the acyl group.   The dentifrice composition according to claim 1 or 2, wherein the water-insoluble granules are particles formed by granulating at least one water-insoluble material selected from silica, zeolite, calcium phosphate, calcium carbonate and aluminum hydroxide.   The component (A) is 0.01 to 0.2% by mass, the component (B) is 0.1 to 0.8% by mass, and the component (C) is 1 to 5% by mass. The dentifrice composition according to item 1.   (C) / (B) is 1-50 as mass ratio, The dentifrice composition of any one of Claims 1-4.   The dentifrice composition according to any one of claims 1 to 5, further comprising (D) 2 to 200 units / g of dextranase.   The dentifrice composition according to any one of claims 1 to 7, which is a toothpaste containing an abrasive having an average particle size of 5 to 40 µm.