JP2018031713A - Automatic analyzer and laboratory information system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To notify an inspection engineer who operates an automatic analyzer which cannot analyze some inspection items by generating an alarm, but it is difficult to determine whether the operation state of the device should be stopped immediately, and the operation state is changed. If this is continued, a plurality of samples in which the test items that cannot be analyzed remain as untested will be generated at random. An automatic analyzer includes a communication means for communicating between an examination room information system and an operation unit, and the operation unit LIS the state information (non-analyzable item) of the automatic analyzer via the communication means. By sequentially transmitting to, when an abnormality occurs in some test items and analysis is not possible, it is possible to easily, reliably and efficiently perform the operation of re-loading the sample together with the rack into another automatic analyzer. it can. [Selection diagram] Fig. 2

Description

  The present invention relates to an automatic analyzer that analyzes a sample such as blood and urine in a clinical test, and a laboratory information system that is a host system for controlling the automatic analyzer.

  Automatic analyzers that perform qualitative / quantitative analysis of biological samples such as blood and urine are widely used mainly in many large hospitals and examination centers because of the need for rapid analysis and accuracy.

  In addition, in order to control these automatic analyzers, a laboratory information system (Laboratory Information System: hereinafter referred to as LIS), which is a host system of the automatic analyzer, has been introduced into the laboratory.

  Conventionally, an automatic analyzer in which some of the inspection items cannot be analyzed generates an alarm and notifies an operating inspection engineer, but the operation state of the automatic analyzer continues until it is intentionally stopped. It is difficult to immediately determine whether the apparatus should be stopped. If the operation state is continued, a plurality of specimens in which the analysis items that cannot be analyzed remain as untested are generated.

  On the other hand, in Patent Document 1, when an abnormality occurs and a sample that cannot be analyzed or a sample that needs to be re-analyzed is generated, the analysis of another sample installed in the rack is awaited. Samples that could not be analyzed or that need to be re-analyzed are displayed to the operating technician using the rack identification information, and samples that need to be re-analyzed or for re-analysis An automatic analyzer that identifies a sample to be collected, has means for instructing collection by interrupting analysis of a sample rack on which the sample is installed, and is capable of collecting and re-inserting a specific sample Presented.

International Publication No. 2010/122718

  According to Patent Document 1, when a sample that has failed and cannot be analyzed or a sample that needs to be re-analyzed is generated, it is not necessary to wait for the end of the analysis of another sample installed in the rack. The entire rack can be collected.

  However, there is a problem that a rack in which a sample satisfying the setting condition based on the parameters registered in advance is always semi-fixed, that is, the analysis is interrupted and the rack recovery process is performed.

  Also, the rack usually has a position where multiple specimens are installed, and if an abnormality occurs at an intermediate position, the specimen that was processed normally and the specimen that was unprocessed because it was interrupted were mixed. There is also concern about becoming a state. For this reason, there is still room for improvement.

  The present invention has been made in view of the above. The state changes of a plurality of automatic analyzers are sequentially transmitted from the automatic analyzer to the LIS, and these are grasped and managed by the LIS. Depending on the combination of whether or not items can be analyzed by multiple automatic analyzers, the LIS can determine whether it should be analyzed directly with the automatic analyzer installed first or with another automatic analyzer. It is possible to respond flexibly, for example, by processing analysis item information to be transmitted to a partially generated automatic analyzer and prompting to re-install it on another automatic analyzer without analyzing all items. Accordingly, an object of the present invention is to realize an automatic analyzer and LIS that can more appropriately support the operation of an operator such as an operating laboratory technician.

  In an aspect of the present invention for achieving the above-described target, an input unit that inputs a sample, a processing unit that processes the sample, a storage unit that stores the processed sample, the input unit, the processing unit, and Communication between the LIS and the first operation unit in an automatic analyzer including a sample transport line for transporting a sample between the storage units, and a first operation unit that controls the input unit, the processing unit, and the storage unit A first communication unit for performing the above, wherein the first operation unit sequentially transmits state information of the automatic analyzer to the LIS via the first communication unit.

  In another aspect of the present invention, the LIS includes an operation unit having a database that holds the device states of a plurality of automatic analyzers controlled by the LIS, and the analysis items of the sample racks input to the automatic analyzer are stored in the LIS. , A function to determine whether or not some of the inspection items cannot be analyzed by the automatic analyzer when returning as a response when inquiring to the LIS from the automatic analyzer, and all inspection items by other automatic analyzers The LIS is equipped with a function for determining whether or not it is desirable to collectively analyze the LIS.

  In another aspect of the present invention, the content of the analysis item information returned to the automatic analyzer is “no item to be analyzed” or “recommend analysis with other device” in the sample rack unit. The LIS is provided with a function capable of setting the information to the effect in the calculation unit of the LIS.

  In the autoanalyzer and LIS that adopts the present invention, when an abnormality or the like has occurred in some test items of some autoanalyzers and analysis is not possible, the samples are loaded into the other autoanalyzers together with the racks. The correction operation can be performed easily, surely and efficiently.

It is a block diagram showing the structural example of an automatic analyzer. It is a block diagram showing the structural example of LIS. It is a figure showing a part of database of LIS. It is a figure showing the process which produces | generates analysis item information in the calculating part of LIS. FIG. 5 is a diagram illustrating processing subsequent to FIG. 4. It is a figure showing an example of the parameter setting screen of LIS. It is a figure showing having added the judgment processing by the parameter of FIG. 6 to a part of FIG. It is a figure showing an example of the parameter setting screen of LIS. FIG. 7 is a diagram showing that a determination process based on the parameters of FIG. 8 is added to FIG. FIG. 5 is a diagram showing that processing for determining the flag updated in the processing in FIG. 9 is added to FIG.

  Embodiments of the present invention will be described below with reference to the drawings.

  FIG. 1 is a block diagram showing an automatic analyzer 1.

  An automatic analyzer 1 shown in FIG. 1 includes an input unit 11, a processing unit 12, a storage unit 13, and an operation unit 16 (first operation unit) including a communication unit 15 (first communication unit) with each device. And a sample transport line 18 for transporting the sample from the input unit 11 to the processing unit 12 and the storage unit 13 and for transporting the sample from the storage unit 13 to the input unit 11 and the processing unit 12.

  The loading unit 11 is a portion for loading a sample rack 314 (hereinafter also referred to as a rack 314) on which a sample container 313 containing a sample is installed into the automatic analyzer 1, and includes a sample scanner 11a. . The sample scanner 11a is a device that reads the sample barcode attached to the sample container 313 loaded from the loading unit 11 and recognizes the identifier of the rack 314 that houses the sample container 313, and which sample container 313 is which rack. It is used to specify whether it is installed at a position in 314.

  The processing unit 12 is a part that processes the sample, that is, a part that analyzes the concentration of the biological component contained in the sample. The processing unit 12 includes the reaction vessel 301, the reaction disk mechanism 302, the thermostat 303, Reagent storage unit 304, specimen dispensing mechanism 305, reagent dispensing mechanism 306, stirring mechanism 307, cleaning mechanism 308, light source 309, photometer 310, A / D (Analog / Digital) converter 311, Have

  The reaction container 301 is a container in which a reagent and a sample are put and reacted.

  The reaction disk mechanism 302 is a member that holds a plurality of reaction vessels 301. The reaction disk mechanism 302 conveys the reaction vessel 301 installed in the reaction disk mechanism 302 to a designated position.

  The thermostat 303 is a mechanism for keeping the reaction vessel 301 installed in the reaction disk mechanism 302 at a predetermined temperature, and keeps the reaction vessel 301 at a predetermined temperature.

  The reagent storage unit 304 is a member that holds a plurality of reagent bottles 312 that are containers for storing reagents used for analysis. In addition, the reagent storage unit 304 transports the reagent bottle 312 installed in the reagent storage unit 304 to a designated position.

  The sample dispensing mechanism 305 includes a sample dispensing probe and is a device that divides a sample into small amounts of a certain amount. The sample dispensing mechanism 305 dispenses a predetermined amount of the sample in the sample container 313 into the reaction container 301.

  The reagent dispensing mechanism 306 includes a reagent dispensing probe, and is a device that divides the reagent into a predetermined small amount. The reagent dispensing mechanism 306 dispenses a predetermined amount of the reagent contained in the reagent bottle 312 into the reaction container 301.

  The agitation mechanism 307 is an apparatus that agitates the reagent and the sample solution contained in the reaction vessel 301 to make the component distribution state uniform.

  The cleaning mechanism 308 is a device that sucks waste liquid and discharges cleaning liquid. The cleaning mechanism 308 aspirates the reagent and sample solution contained in the reaction container 301. Further, the cleaning mechanism 308 cleans the reaction container 301 by discharging a cleaning liquid into the reaction container 301.

  The light source 309 is a portion that emits light used for absorbance measurement, and includes a halogen lamp or the like.

  The photometer 310 is a part that receives the light emitted from the light source 309 and passed through the reaction vessel 301 and measures the absorbance of the solution in the reaction vessel 301, and is constituted by a spectrophotometer or the like. The photometer 310 transmits absorbance information to the A / D converter 311.

  The A / D converter 311 is a device that converts an analog signal into a digital signal. The A / D converter 311 converts the input analog signal into a digital signal, and then records it in the database 17.

  The storage unit 13 is a part that stores the processed sample, that is, the rack 314.

  The communication unit 15 is a member such as a cable or a radio that performs mutual communication between the mechanisms in the automatic analyzer 1. The communication unit 15 communicates between the LIS 2 and the operation unit 16.

  The operation unit 16 links information with the LIS 2 via the communication unit 15, exchanges analysis item information, analysis results, and the state of the automatic analyzer, updates the contents of the database 17, and sends the contents to the monitor 14. Is displayed and the speaker 19 is sounded as necessary. The operation unit 16 also controls the input unit 11, the processing unit 12, and the storage unit 13. Further, the operation unit 16 sequentially transmits the state information of the automatic analyzer 1 to the LIS 2 via the communication unit 15.

  FIG. 2 is a block diagram showing LIS2.

  The operation unit 116 (second operation unit) of the LIS 2 shown in FIG. 2 links the information with the plurality of automatic analyzers 1 through the communication unit 115 (second communication unit), updates the contents of the database 117, and monitors The contents are displayed at 114, and the speaker 119 is sounded as necessary.

  The communication means 115 communicates with a plurality of automatic analyzers controlled by the LIS 2 and the operation unit 116.

  That is, the operation unit 116 sequentially receives the state information of each automatic analyzer transmitted sequentially from the plurality of automatic analyzers 1 via the communication unit 115, sequentially stores it in the database 117, and stores it in the database 117. The status information of each automatic analyzer 1 is updated sequentially. The representative state information is analysis availability status information for each analysis item for each automatic analyzer for creating the inspection item status table 203 of FIG.

  In addition to the case where specific analysis items cannot be analyzed in advance on the automatic analyzer side by updating the sequential status information in advance, the analysis items that were initially available for analysis may be analyzed during the operation status due to reasons such as a lack of reagents. Even when the availability is changed, it is possible to quickly operate the apparatus corresponding to the state change. For example, it is possible to avoid a situation in which some uninspected items remain in rack units.

  In accordance with an instruction from the operation unit 116, the calculation unit 120 generates analysis item information with reference to the contents of the database 117 and returns the information to the operation unit 116. That is, the arithmetic unit 120 generates analysis item information for determining which items each automatic analyzer 1 analyzes for a specific rack 314.

  The automatic analyzer 1 in FIG. 2 shows the same components as those in FIG. 1, and the detailed components are not shown.

  FIG. 2 shows an example in which one LIS 2 controls three automatic analyzers 1 as an example. However, the number of components of the automatic analyzer 1 and whether or not they are connected can be freely combined depending on the operation business condition of the laboratory.

  FIG. 3 is an example of tabular data showing a part of the details of the LIS2 database 117.

  In the database 117 of LIS2, in addition to information related to patient specimens, the operating status of each of the plurality of automatic analyzers 1 controlled by LIS2 (whether it can be used or not) based on information received via communication means 115 ), And an analysis possible item status (analysis availability status information) are recorded.

  The operating status table 201 holds an operating status 202 for each automatic analyzer 1 controlled by the LIS 2. In the example of FIG. 3, the automatic analyzer 1 (device number 3) whose operation status is other than “0” indicates that it is not operating or is not operating due to maintenance such as cleaning or parts replacement. The automatic analyzer 1 whose status is “0” indicates that it is operating (device numbers 1 and 2).

  The inspection item status table 203 holds an analysis availability status 204 (analysis availability status information) for each inspection item that can be analyzed by the automatic analyzer 1 controlled by the LIS 2. In the example of FIG. 3, an analysis item whose analysis availability status is “0” can be analyzed, and an inspection item whose analysis availability status is “other than 0” cannot be analyzed.

  4 and 5 are flowcharts for realizing processing for generating analysis item information in the calculation unit 120 of LIS2.

  The calculation unit 120 of the LIS 2 that has received the analysis item inquiry from the automatic analyzer 1 via the operation unit 116 first starts processing (step S30).

  Here, the operation unit 116 receives an inquiry about an analysis item to be analyzed by the automatic analyzer with respect to a specific rack to be analyzed by the automatic analyzer 1. Which analysis item a specific rack or a specific sample is scheduled to be analyzed is stored in the database 117. For example, an identifier such as a bar code of a rack or a sample container is read by the sample scanner 11a from the operation unit 15 to the operation unit. An inquiry is made to 116.

  Next, the arithmetic unit 120 starts a repeat process (first loop) for the number of samples (maximum number of positions) in rack units inquired from the automatic analyzer 1 (step S31).

  Next, the calculation unit 120 initializes the analysis item information (for the device) of the position sample and the analysis impossibility flag (for the number of all devices) (steps S32 and S33).

  Next, the calculation unit 120 starts a repeat process (second loop) for the number of requested items of the position sample (step S34).

  The circle A will be described later.

  Next, the calculation unit 120 collates the inspection item status table 203 updated based on the information transmitted from the sequential automatic analyzer 1, and determines whether the item can be analyzed by the device (step S35). If it is determined that analysis is possible, the process proceeds to step S41. If it is determined that analysis is not possible, the process proceeds to step S36.

  The calculation unit 120 that has proceeded to step S36 switches on the analysis impossibility flag of the device of the position sample, and then the calculation unit 120 starts a repeat process (third loop) for the number of devices other than the device. (Step S37).

  Next, the calculation unit 120 determines whether the item can be analyzed by another device (step S38). When it is determined that analysis is possible, the process proceeds to step S40, and when it is determined that analysis is not possible, the process proceeds to step S39.

  The calculation unit 120 that has proceeded to step S39 turns on the analysis impossible flag of the position sample / other apparatus.

  Step S40 represents the end position of the third loop, and the process proceeds to step S41 after the repetition process ends.

  Next, the computing unit 120 adds the item to the analysis item information of the position sample (step S41). Note that the reason why the item is also added to the analysis item information in spite of having determined that the device cannot be analyzed once in step S35 is that the analysis item information is generated by the calculation unit 120 of the LIS 2 and then sent to the automatic analysis device 1. This is because the possibility that the item has been changed to a state where it can be analyzed by taking action on the automatic analyzer 1 during this time is considered.

  Steps S42 and S43 represent the end positions of the second loop and the first loop, and repeat processing is performed for each.

  The circle B will be described later.

  A circle C represents a continuous position in FIGS. 4 and 5.

  Next, the arithmetic unit 120 determines whether or not the analysis flag of the device is on (step S44). When it is determined to be on, the process proceeds to step S45, and when it is determined to be other than on (hereinafter referred to as off), the process proceeds to step 51.

  The calculation unit 120 that has proceeded to step S45 starts a repeat process (fourth loop) for the number of devices other than the device.

  Next, the arithmetic unit 120 determines whether the analysis disable flag of the other device is on (step S46). When it is determined to be on, the process proceeds to step S47, and when it is determined to be off, the process proceeds to step S48.

  Step S47 represents the end position of the fourth loop, and the process proceeds to step S51 after the repetition process ends.

  The calculation unit 120 that has proceeded to step S48 exits the fourth loop, and determines whether or not the other device can receive information indicating that “analysis with another device is recommended”. When it is determined that reception is possible, the process proceeds to step S49, and when it is determined that reception is not possible, the process proceeds to step S50.

  The computing unit 120 that has proceeded to step S49 sets information indicating that “analysis with another apparatus is recommended” instead of the analysis item information of the rack, and then proceeds to step S51.

  The computing unit 120 that has proceeded to Step S50 initializes the analysis item information of all the samples of the rack, sets the state of “no item to be analyzed”, and proceeds to Step S51.

  The calculation unit 120 that has shifted to step S51 transmits the generated analysis item information to the LIS 2 via the operation unit 116, and ends a series of processes.

  With these processing flows shown in FIG. 4 and FIG. 5, there is no request for an item that cannot be analyzed for all the position samples in the operation using the installation container using the rack 314 of one rack and a plurality of positions, and the automatic analyzer 1 has a problem. If the analysis can be performed without any problem, the analysis item information is set as usual, and the operation state of the automatic analyzer 1 is continued so as not to lower the efficiency.

  Conversely, if there is a request for an item that cannot be analyzed for a sample at a certain position, the analysis item information is initialized so that all the position samples are not analyzed, and the state is set to “There is no item to be analyzed”. The data is transmitted to the analyzer 1 to realize early rack collection.

  As described above, the calculation unit 120 generates analysis item information based on the item information scheduled to be analyzed for the sample rack and the analysis availability information stored in the database 117. The calculation unit 120 does not simply generate item information to be analyzed as analysis item information but adds analysis availability information.

  For example, the arithmetic unit 120 analyzes whether a specific rack 314 is analyzed by the automatic analysis device 1 that has been inquired based on each analysis availability status information of each automatic analysis device. And it is judged whether it is desirable to analyze with other automatic analyzer 1 which LIS2 controls instead of the automatic analyzer 1 which was inquired. When the arithmetic unit 120 determines that it is desirable to analyze the specific rack 314 with the other automatic analyzer 1, the calculation unit 120 initializes the item information to be analyzed for the specific rack 314 and automatically performs the inquiry. The initialized information is transmitted to the analyzer 1.

  In addition, when the arithmetic unit 120 determines that it is desirable to analyze a specific rack 314 with another automatic analyzer, the automatic analyzer that has inquired “recommends analysis with another device”. In the case of an automatic analyzer capable of receiving information by determining whether information can be received, it is also possible to generate information indicating “recommend analysis with other devices” instead of analysis item information. In the implementation, it is desirable to be able to select whether or not to set information indicating “recommend analysis with other devices” instead of analysis item information as an option.

  The rack 314 that does not analyze all the position samples in the automatic analyzer 1 and collects them in the storage unit 13 based on the analysis item information from the LIS 2 is different from the rack 314 in which the samples that have been analyzed are installed normally. It is desirable to have an implementation that allows the operator (testing engineer) to easily understand that the sample group has a mechanism to be collected at the site and should be analyzed by another device. That is, the storage unit 13 has a collection position different from that of the rack 314 that has been subjected to normal analysis, and the operation unit 16 receives the initialized information or “recommends analysis with another device”. When receiving the information to the effect, it is desirable that the information is conveyed to the collection position without being analyzed by the automatic analyzer 1 that is inquired regardless of the item information to be analyzed.

  The operation unit 16 of the automatic analyzer 1 that has received the information “recommend analysis by other device” from the LIS 2 generates an alarm on the monitor 14 or the speaker 19, and the rack 314 or the sample on the monitor 14. It is desirable that the operator is informed that “analysis with another device is recommended” by highlighting the position.

  So far, we have described how to realize operations that do not leave uninspected items, but on the other hand, priorities are set for each inspection item, and items with low priority and urgent analysis results are left unexamined. It is also possible to envisage an operation that does not matter.

  FIG. 6 shows an example of a parameter screen of LIS2 for registering the priority for each inspection item as an example for dealing with this operation.

  FIG. 7 is a diagram showing that a determination process (step S61) based on the parameters in FIG. 6 is added between a part of FIG. 4, that is, between the circle A and the circle B described above.

  In step S61, the calculation unit 120 determines whether the priority of the item is “low”. When it is determined as “low”, all subsequent processes are not performed, and the process proceeds to step S41. If it is determined to be other than “low”, the process proceeds to step S36.

  4, 5, and 7, even if there is a request for a non-analyzable item in some position samples and analysis cannot be performed by the automatic analyzer 1, the priority is low. If only the inspection item cannot be analyzed, the analysis item information can be set as usual and analyzed by the automatic analyzer 1 as it is. Those items will remain untested in the device depending on the operation desired by the operator.

  In addition to the priority for each examination item, whether the sample is left untested or not is determined in the same manner as the determination process (step S61) in FIG. It can also handle carving. The analysis item information generation process for leaving the specimen untested using the sample attribute can be determined and processed in the same manner as the item priority handling shown in FIG.

  As described above, the priority for each examination item or the attribute of the specimen is stored in the database 117, and the arithmetic unit 120 makes an inquiry based on the analysis availability information of the requested automatic analyzer. When the rack 314 is analyzed, it is determined whether or not some untested items remain, and the arithmetic unit 120 determines whether or not the test items stored in the database 117 have priorities or sample attributes. When it is possible to allow a situation in which some uninspected items remain, it is desirable to generate item information to be analyzed as analysis item information and send it to the automatic analyzer that has made the inquiry. Whether or not it is permissible can be previously registered for each item in the database 117 as shown in FIG. 6 so that the calculation unit 120 can accept the situation where an unexamined item remains, or an item to be analyzed without being allowed. Determine whether to initialize the information.

  By the way, in the automatic analyzer 1, analysis results may be due to physical factors such as lack or deterioration of consumables such as reagents and diluents, and insulation failure or deterioration of electrodes that analyze the concentration of electrolyte Cannot be output.

  On the other hand, in addition to these, analysis results can be obtained, such as avoiding carryover with water due to lack of detergent and performing calibration with expired reagents. Exists.

  These factors of "physical" and "credibility anxiety" are differentiated while being shared by the automatic analyzer 1 and the LIS 2, and the device status transmitted from the automatic analyzer 1 to the LIS 2 is also distinguished and transmitted / received. Can be assumed.

  As an embodiment for dealing with this operation, the meaning of “analysis availability status” in the inspection item information table shown in FIG. 3 is expanded, for example, “0 = analysis possible”, “1 = analysis impossible (physical ) ”,“ 2 = analysis impossible (credibility anxiety) ”,“ 3 = analysis impossible (others) ”, etc., and parameters are provided on the LIS 2 side as shown in FIG.

  FIG. 9 shows an example in which the determination process (steps S62 and S63) of the calculation unit 120 of the LIS2 corresponding to the parameters shown in FIG. 8 is added to the processing flow of FIG.

  In step S62, the calculation unit 120 determines whether or not the factor that cannot be analyzed is physical. If it is determined that it is physical, if “processing condition = uninspected” is set in the parameters shown in FIG. 8, the process proceeds to step S65. If it is determined that it is physical, if “processing condition = other device” is set in the parameters shown in FIG. 8, the process proceeds to step S64. When it is determined that it is not physical, the process proceeds to step S63.

  Next, in S63, the calculation unit 120 determines whether there is a factor that causes anxiety in the credibility of the result of the item. When it is determined that there is anxiety about the credibility, if “processing condition = untested” is set in the parameters shown in FIG. 8, the process proceeds to step S65. When it is determined that there is anxiety about the credibility, if “processing condition = other device” is set in the parameters shown in FIG. 8, the process proceeds to step S64. When it is determined that there is no concern about credibility, the process proceeds to step S36.

  The calculation unit 120 that has proceeded to step S64 turns on the other device recommendation flag of the position sample. Although the illustration of the flag is omitted, it is necessary to initialize the flag immediately before entering the second loop at the latest.

  The calculation unit 120 that has proceeded to step S65 determines again whether or not the factor that the item cannot be analyzed is physical. If it is determined that it is physical, the process proceeds to step S41. When it is determined that it is not physical, it moves to the position before the circle B, that is, the end position of the second loop.

  The significance of this step S65 is that there is anxiety in the credibility of the analysis result, but the result is in a state of being output. Therefore, if the item is added to the analysis item information to the device, it has been inspected in the same way as the normal item. , To avoid getting confused as it is. By not adding the item to the analysis item information for the device, an untested item on the device does not occur, but it remains untested on the LIS2, and there is anxiety about authenticity outside the clinical laboratory. It is possible not to report certain analysis results.

  However, it is appropriate that the idea of this step S65 can be selected according to the operation desired by the operating operator. In other words, it is possible to analyze with the device and report to the clinic at the operator's discretion, or stop and re-inspect with another device. Can be used as a treatment.

  The status information includes the presence / absence of factors that cannot physically analyze the items and the presence / absence of factors that are uncertain about the credibility of the analysis results, and the operation unit 16 determines whether or not these factors exist in the LIS 2 that controls the automatic analyzer. Is desirable to send.

  Further, the operation unit 116 receives, as status information, the presence / absence of a factor that cannot physically analyze an item and the presence / absence of a factor that is uneasy about the credibility of the analysis result, and determines whether or not to analyze in advance for each factor. The table is stored in the database 117, and the calculation unit 120 processes the item information to be analyzed based on the table and generates the analysis item information as an analysis item information when there is any of the factors. It is desirable to send it to an automatic analyzer that has

  FIG. 10 shows an example in which an additional device recommendation flag determination process (step S66) of the position sample is added to FIG.

  In step S66, the arithmetic unit 120 determines whether the other device recommendation flag is on. When it is determined to be on, the process proceeds to step S49. If it is determined to be off, the process proceeds to step S48.

  These added determination processes allow flexible operation of the system desired by the operating operator.

  In this example, multiple “physical” factors and “credibility anxiety” factors are grouped together, but how much they are subdivided to be distinguished and controlled is considered in implementation. It should be.

  So far, physical factors and the credibility of analysis results have been described, but the operator intentionally stops the analysis of some inspection items (hereinafter referred to as intentional item mask). There is. Intentional item masks indicate that the operating operator knows that it is not desirable to continue analysis as is, such as reagent deterioration or expiration, and in a sense. It can also be referred to as “degenerate operation” in item units.

  Such intentional item masking is performed by the operator's intention, and it is natural for the operating operator to know that the inspection item of the automatic analyzer 1 is not inspected. Therefore, the behavior that does not analyze all the samples in the rack 314 on which the samples including the intentionally masked items are installed may be confusing to the operator.

  Therefore, it can be assumed that an item that has been intentionally masked is not as urgent as the content described in the item priority handling and may be left unchecked. Analysis item information generation processing for leaving an intentional mask item unexamined can be determined and processed in the same manner as the item priority handling shown in FIG. 7, and is not shown.

  On the other hand, as a function of the automatic analyzer 1, there is an operation of automatically masking inspection items satisfying a certain condition (hereinafter referred to as an apparatus recommended mask).

  Although such an apparatus recommended mask is automatically given and an alarm or the like is generated at the same time, it is not always transmitted to an operating operator.

  Therefore, the device recommended mask is not handled in the same way as the intentional item mask, and an individual judgment process is implemented and whether to analyze everything with another device or leave it partially unchecked with the device. Should be implemented so that the operator can choose.

  As described above, the determination process related to the device recommended mask can be dealt with by adding parameters and determination processing to the automatic analyzer 1 and the transmission / reception interface between the LIS 2 and the LIS 2, and therefore a specific illustration is omitted.

  By implementing these functions, it is possible to automatically process whether or not it is desirable to analyze all the inspection items together by any of the multiple automatic analyzers in the rack unit where the sample is installed. As a result, the operator's judgment and manual work can be reduced, and work efficiency can be improved.

  In the above-described embodiment, the automatic analyzer that performs biochemical analysis of blood or the like has been described as an example of the automatic analyzer. However, the automatic analyzer is not limited to the biochemical analyzer, and immunological analysis is performed. The present invention can also be applied to an immunoanalyzer that performs the above, an apparatus that integrally analyzes both biochemistry and immunology, and the like.

  According to the above embodiment, the following effects can be obtained.

  In an operation that batch processes a large number of samples with multiple automatic analyzers, when an abnormality occurs in some inspection items of some automatic analyzers and analysis is not possible, the samples are sent to other automatic analyzers along with the racks. It is easy, reliable, and efficient with respect to the operation of re-injecting.

DESCRIPTION OF SYMBOLS 1 ... Automatic analyzer, 2 ... LIS, 11 ... Input part, 12 ... Processing part, 13 ... Storage part, 14.114 ... Monitor, 15.115 ... Communication Means, 16 · 116, operation unit, 17 · 117, database, 18 ... specimen transport line, 19 ... speaker, 120 ... calculation unit, 30 ... analysis item information generation process, 201 ... operation status table, 202 ... operation status table registration content, 203 ... inspection item status table, 204 ... inspection item status table registration content, 211 ... inspection item parameter screen, 212. Inspection item parameter setting contents, 221 ... analysis condition setting parameter screen, 222 ... analysis condition setting parameter setting contents, 301 ... reaction vessel, 302 ... reaction disk mechanism, 303 Constant temperature bath 304: Reagent storage unit 305 ... Sample dispensing mechanism 306 ... Reagent dispensing mechanism 307 ... Stirring mechanism 308 ... Cleaning mechanism 309 ... Light source 310 ... Photometer, 311 ... A / D converter, 312 ... Reagent bottle, 313 ... Sample container, 314 ... Rack

Claims (11)

A loading unit for loading a sample, a processing unit for processing the sample, a storage unit for storing the processed sample, and a sample transport line for transporting the sample between the loading unit, the processing unit, and the storage unit And an automatic analyzer including a first operation unit that controls the input unit, the processing unit, and the storage unit,
A first communication means for performing communication between the laboratory information system and the first operation unit,
The first operation unit sequentially transmits state information of the automatic analyzer to the laboratory information system via the first communication means. In the laboratory information system for controlling the automatic analyzer according to claim 1,
A second operation unit;
A second communication means for communicating with a plurality of automatic analyzers controlled by the laboratory information system and the second operation unit;
A database, and
The second operation unit sequentially receives status information of each automatic analyzer transmitted sequentially from a plurality of automatic analyzers via the second communication means, sequentially stores the information in the database, and stores the information in the database. A laboratory information system characterized by sequentially updating the state information of each automatic analyzer. In the laboratory information system of claim 2,
Further, the automatic analyzer includes a calculation unit that generates analysis item information for determining which item is analyzed for a specific sample rack,
The state information is analysis availability status information for each analysis item,
The second operation unit receives an inquiry about an analysis item to be analyzed by the automatic analyzer for a specific sample rack to be analyzed by the automatic analyzer,
The laboratory information system, wherein the calculation unit generates the analysis item information based on the item information scheduled to be analyzed for a specific sample rack and the analysis availability information. In the laboratory information system of claim 3,
The arithmetic unit, based on each analysis availability status information of each automatic analyzer, when analyzing a specific sample rack in the automatic analyzer that has been inquired, whether or not there is a situation where some untested items remain, and Judge whether it is desirable to analyze with other automatic analyzers controlled by the laboratory information system rather than the automatic analyzer that was inquired,
When it is determined that it is desirable to analyze a specific sample rack with another automatic analyzer, the arithmetic unit initializes item information scheduled for analysis with respect to the specific sample rack to the automatic analyzer that has received the inquiry. A laboratory information system characterized by transmitting initialized information. In the laboratory information system of claim 3,
The arithmetic unit, based on each analysis availability information of each of the automatic analyzers, when analyzing a specific sample rack in the automatic analyzer that has been inquired, whether or not some untested items remain, And it is determined whether it is desirable to analyze with other automatic analyzers controlled by the laboratory information system instead of the automatic analyzer that was inquired,
When it is determined that it is desirable to analyze a specific sample rack with another automatic analyzer, the calculation unit can receive information indicating that the inquired automatic analyzer recommends analysis with another device. Therefore, in the case of an automatic analyzer capable of receiving this information, the laboratory information system is characterized in that, in place of the analysis item information, information for recommending analysis by another device is generated. In the automatic analyzer controlled by the laboratory information system of claim 4,
Furthermore, the storage unit has a collection position different from the sample rack for which normal analysis has been completed,
When the first operation unit receives the initialized information, the first operation unit transports the first operation unit to the collection position without analyzing by the automatic analyzer that is inquired regardless of the item information to be analyzed. Automatic analyzer. In the automatic analyzer controlled by the laboratory information system of claim 5,
Furthermore, the storage unit has a collection position different from the sample rack for which normal analysis has been completed,
When the first operation unit receives information indicating that analysis by another device is recommended, the first operation unit is placed in the collection position without performing analysis by the automatic analysis device inquired regardless of the item information scheduled for analysis. An automatic analyzer characterized by conveying. In the automatic analyzer controlled by the laboratory information system of claim 5,
When you receive information that recommends analysis on another device,
The first operation unit generates an alarm on a monitor or speaker and highlights the position of a specific sample rack or sample on the monitor to notify the operator that analysis by another device is recommended. The automatic analyzer characterized by doing. In the laboratory information system of claim 3,
Priorities for each test item or specimen attributes are stored in the database,
The arithmetic unit analyzes whether a specific sample rack is analyzed by the inquired automatic analyzer based on the analysis availability information of the inquired automatic analyzer, and whether or not some untested items remain Determine whether
If the calculation unit can tolerate a situation in which the partially untested item remains based on the priority for each test item stored in the database or the attribute of the sample, the item information to be analyzed Is generated as the analysis item information, and is transmitted to the automatic analyzer that has been inquired. The apparatus of claim 1.
The state information includes the presence / absence of a factor that cannot physically analyze the item and the presence / absence of a factor that is anxious about the credibility of the analysis result,
The first operation unit transmits the presence / absence of these factors to a laboratory information system that controls the automatic analyzer. The laboratory information system according to claim 9, which controls the automatic analyzer according to claim 10.
The second operation unit receives the presence / absence of a factor that cannot physically analyze the item and the presence / absence of a factor that causes anxiety in the credibility of the analysis result as the state information,
A table defining whether to analyze in advance for each of the factors is stored in the database,
The calculation unit processes the item information to be analyzed based on the table when there is any one of the respective factors, generates the analysis item information, and automatically analyzes the inquiry A laboratory information system characterized by being transmitted to an apparatus.

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