JP2018016588A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral composition capable of exerting an excellent improvement effect such as sexual capability more rapidly and more effectively.SOLUTION: There is provided an oral composition which comprises: an arginine-containing composition comprising arginine, sodium aspartate and citrulline, proanthocyanidin; and a proanthocyanidin-containing composition comprising zinc. The arginine-containing composition is preferably used as a granule and the proanthocyanidin-containing composition is preferably used as a hard capsule. The arginine-containing composition further preferably comprises vitamin C, vitamin E and folic acid and the proanthocyanidin-containing composition preferably comprises creatine, an Eurycoma longifolia extract, coenzyme Q10, vitamin B6 and vitamin B12.SELECTED DRAWING: None

Description

  The present invention relates to an oral composition, in particular, an oral composition for improving male sexual function.

  Conventionally, taking arginine and proanthocyanidins in combination has been known to be effective in improving sexual functions in men, such as erectile dysfunction (ED), infertility, and reduced energy, and oral supplements containing these Compositions have been developed (see, for example, Patent Document 1). The decline in male sexual function is often caused by decreased blood flow. Therefore, in patent document 1, the improvement of a blood flow is promoted by ingesting the arginine and proanthocyanidin which have the vasodilator effect, and the improvement of a sexual function is aimed at. Patent Document 2 discloses that ingestion of an oral preparation containing citrulline and arginine improves blood flow and is effective against symptoms of erectile dysfunction.

JP-T-2006-515359 International Publication No. 2009/048148

  However, the oral composition of Patent Document 1 requires ingestion for several months or more before the effect of improving sexual function appears, and there is a problem in immediate effect and the like. In the oral composition of patent document 2, it is not specifically described whether the sexual function was fully eliminated. Therefore, it is desired to develop an oral composition that is excellent in improving the sexual function and can be obtained more quickly.

  The present invention has been made paying attention to the above problems, and an object thereof is to provide an oral composition capable of exhibiting an excellent improvement effect such as sexual function faster and more effectively. .

  In order to achieve the above object, an oral preparation of the present invention comprises an arginine-containing composition containing arginine, sodium aspartate, and citrulline, and a proanthocyanidin-containing composition containing proanthocyanidins and zinc. is there.

  ADVANTAGE OF THE INVENTION According to this invention, the oral composition which can exhibit the outstanding improvement effect, such as a sexual function, faster and more effectively can be provided.

  Hereinafter, an embodiment of the oral composition of the present invention will be described. The oral composition according to this embodiment has an arginine-containing composition containing arginine, sodium aspartate, and citrulline, and a proanthocyanidin-containing composition containing proanthocyanidins and zinc. The oral composition according to the present embodiment is for oral ingestion and oral administration to humans or non-human animals, and supplements such as health foods, functional foods, dietary supplements, foods for specified health use, etc. It can be provided as a food or drink or as a medicine.

  Arginine, sodium aspartate, and citrulline may be any of L-form, D-form and DL-form, but L-form is desirable.

  The arginine-containing composition preferably further contains at least one selected from vitamin C, vitamin E, and folic acid in addition to arginine, sodium aspartate, and citrulline, and further contains two or more components. It is more desirable to contain all these components. Moreover, components other than these can also be contained.

  The proanthocyanidin-containing composition preferably further contains at least one selected from creatine, tonkat ant extract, coenzyme Q10, vitamin B6, and vitamin B12 in addition to proanthocyanidins and zinc, It is more desirable to further include two or more components, and it is particularly desirable to include all of these components. In this case, components other than these can also be contained.

  Hereinafter, each component of the arginine-containing composition will be described. Arginine is a kind of amino acid and promotes the secretion of growth hormone, and thus has an effect of improving blood flow by dilating blood vessels. Arginine has effects such as muscle synthesis, improvement of immunity, detoxification of ammonia, etc. in addition to the blood flow improvement effect.

  Aspartic acid is a kind of amino acid, and has an effect of excreting ammonia out of the body by diuretic action, and an effect of recovering fatigue by being involved in nitrogen metabolism and energy metabolism. Since aspartic acid is hardly soluble in water, it is desirable to use sodium aspartate combined with sodium from the viewpoint of improving water solubility.

  Citrulline is a kind of amino acid and is abundant in vegetables such as cucumber and watermelon. Citrulline has the effect of dilating blood vessels by promoting the production of nitric oxide. Therefore, a blood flow improvement effect, a fatigue recovery effect, a muscle enhancement effect, and an energy enhancement effect can be obtained.

  Vitamin C (ascorbic acid) is a kind of water-soluble vitamin, which helps maintain the health of the skin and mucous membranes and has an antioxidant effect. Therefore, it has the effect of improving immunity and resistance to stress.

  Vitamin E is a kind of vitamin having a strong antioxidant action, and has an effect of protecting the body from active oxygen. It also has the effect of preventing aging of blood vessels, skin, cells, etc. and maintaining reproductive function, and the effect of promoting peripheral blood vessels to promote blood circulation.

  Folic acid is a kind of water-soluble vitamin B group, and has an effect of helping the formation of red blood cells together with vitamin B12. In addition, folic acid is mainly consumed by women in early pregnancy because folic acid plays an important role as a nutrient that contributes to the normal development of the fetus. On the other hand, it is known that when men ingest folic acid, it promotes normal sperm division, improves the probability of pregnancy, and lowers the risk of malformation. It is possible to exert an excellent effect on improving the sexual function.

  Next, each component of the proanthocyanidin-containing composition will be described. Proanthocyanidins are a kind of flavonoid, have a strong antioxidant action, and also have an action of activating nitrous oxide synthase in the blood vessel wall to cause vasodilation. Therefore, the effect of improving blood flow can be obtained.

  Proanthocyanidins are contained in many plants such as grapes, bark, tea and cacao. Among these, Pycnogenol (registered trademark, Pinus Pinaster ssp. Natlantica) is preferably used because it contains a large amount of proanthocyanidins. Pycnogenol is a component extracted from the bark of pine that grows naturally in the coastal area in southwestern France, and is also called French coastal pine bark extract, flavangenol, and the like.

  The effects of Pycnogenol include the improvement of sexual function in men such as ED. In addition to this, prevention and improvement of hypertension and diabetes, immune function enhancement, allergy improvement, dysmenorrhea, endometriosis, Examples include thrombus prevention, skin beautification / whitening effect, analgesic effect, improvement of ADHD (attention deficit / hyperactivity disorder), venous insufficiency, varicose vein improvement and the like.

  Zinc is a mineral that is abundant in animal foods such as oysters, meats, and fish, and is involved in protein / nucleic acid metabolism and has the effect of maintaining health and the effect of maintaining a normal taste. In particular, zinc is an essential nutrient in the process of producing sperm in a male body, and taking zinc is effective in improving male sexual functions such as ED and infertility. Although it does not specifically limit as a kind of zinc, Since addition to an insurance functional food is recognized, zinc gluconate is used suitably.

  Creatine is a kind of amino acid stored in muscle as an energy source, has an effect of improving muscular strength, physical function and endurance, and is considered suitable for sports and the like. Therefore, it can be suitably used for the maintenance of male function. Tonkat ant extract is an extract from a plant called Tonkat rear that grows naturally in the rainforest and has been used as a tonic since ancient times. In particular, it is effective for male nutrition and promotion of male hormone secretion.

  Coenzyme Q10 is a type of coenzyme that is necessary for producing energy in the body. Coenzyme Q10 produces ATP and produces a driving force for various life activities, and has a strong antioxidant effect, and thus has a preventive effect on lifestyle-related diseases and aging. Therefore, the effect which improves the quality of a male sperm and the effect which improves the exercise | movement ability of a sperm are acquired.

  Vitamin B6 is a kind of water-soluble vitamin B group, and contributes to amino acid metabolism and neurotransmitter synthesis. Therefore, it has the effect of stabilizing the mental state and adjusting the balance of hormones, improving the sexual function of males, and reducing the symptoms and morning sickness of female PMS (premenstrual syndrome). Vitamin B6 is not particularly limited, but pyridoxine hydrochloride is preferably used.

  Vitamin B12 (cyanocobalamin) is a kind of water-soluble vitamin B group, and is involved in cell metabolism, especially in the synthesis and regulation of DNA and proteins, and in the synthesis of fatty acids and energy production. Is involved in proper metabolism. From this, vitamin B12 has the effect of improving the sperm production function and the effect of improving the sperm motility.

  As described above, according to the oral composition of the present embodiment, an arginine-containing composition excellent in blood flow improvement effect, fatigue recovery effect, etc., an improvement in sperm production function, an improvement in sperm exercise ability, a blood flow improvement effect, etc. By having an excellent proanthocyanidin-containing composition, it is possible to obtain an effect of improving sexual function, particularly an effect of improving male sexual function such as erectile dysfunction and infertility. That is, by ingesting the oral composition of the present embodiment, promotion of secretion of male hormones such as testosterone, adjustment of hormone balance, promotion of sperm production and improvement of sperm quality, etc. are achieved, and sexual function is improved. . In addition to this, it is possible to obtain improvement effects such as stiff shoulders, coldness and swelling, and improvement effects such as premenstrual syndrome (PMS) in women and infertility in women.

  Moreover, while an arginine containing composition contains sodium aspartate and citrulline, while improving the effect of arginine more, the effect can be expressed more rapidly. Moreover, while the proanthocyanidin-containing composition contains zinc, the effects of proanthocyanidins can be further improved and the effects can be expressed more quickly. Therefore, it is possible to provide an oral composition capable of exhibiting superior improvement effects such as male sexual function faster and more effectively.

  Although the arginine-containing composition and the proanthocyanidin-containing composition can be ingested or administered as they are, the oral composition of this embodiment is desirably provided as a known preparation and ingested or administered.

  Examples of the dosage form of the oral composition of the present embodiment include tablets, powders, granules, emulsions, syrups, capsules (hard capsules, soft capsules) and the like. The arginine-containing composition and the proanthocyanidin-containing composition can be the same dosage form or different dosage forms. For example, it is desirable that the arginine-containing composition is a granule or powder, and the proanthocyanidin-containing composition is a capsule. Since an arginine-containing composition contains arginine, the amount of intake is increased, and it is desirable to use a granule or powder rather than a tablet or the like because it is easier to ingest or administer. Proanthocyanidin-containing compositions can provide excellent effects even when the amount of intake is small, so it is easy to ingest or administer by filling into tablets or capsules, and there is no need for packaging, etc. This is desirable because it can be reduced.

  Moreover, when formulating the oral composition of this invention, additives, such as an excipient | filler and a sweetener, can be used, for example. Examples of the excipient include starch, cellulose, saccharides such as sucrose and teat, and among these, starch is preferably used. Examples of the sweetener include aspartame, acesulfame potassium, saccharin sodium, sucralose, stevia, thaumatin and the like. These additives can be used by selecting one type from those exemplified, or a plurality of types can be used in appropriate combination.

  In addition, binders, disintegrants, lubricants, dispersants, suspending agents, emulsifiers, diluents, buffers, antioxidants, bacteria inhibitors, flavoring agents, flavoring agents (additives) Perfume), coloring agents, and the like. There are no particular limitations on the production method and production apparatus for the formulation, and a conventionally known appropriate production method and production apparatus can be selected according to the dosage form and the like.

  The oral composition of the present embodiment can be formulated so as to contain all of the arginine-containing composition and the proanthocyanidin-containing composition, but the tablets and the like are increased, and the intake or dosage is increased. There is. Therefore, it is desirable to formulate the arginine-containing composition and the proanthocyanidin-containing composition separately, and combine them to provide a kit or a set. In this case, it can be provided in the same box or other container, or can be provided in a separate container.

  By providing in such a form, one of the arginine-containing composition and the proanthocyanidin-containing composition can be ingested first, and then the other can be ingested. In addition, by providing separately, the intake etc. can be adjusted according to the symptom and the purpose of improvement, such as increasing the intake of one, etc., and reducing the intake of the other, etc. Ingestion according to the request becomes possible. In addition, it may be sold as a kit or a set, but can also be sold separately, etc., when only one composition has been consumed and the other composition remains, the composition that has been consumed It is sufficient to purchase only goods, and the product is easy for the user to purchase.

  The oral composition of the present embodiment desirably contains the arginine-containing composition at a ratio of 2 parts by weight or more, preferably 4 parts by weight or more with respect to 1 part by weight of the proanthocyanidin-containing composition. As a component ratio, arginine: sodium aspartate: citrulline: proloanthocyanidin: zinc is preferably 250: 60: 17: 1: 2.5.

  The intake amount and the number of intakes of the oral composition of the present embodiment vary depending on the intake form, the age, weight, symptoms, etc. of the recipient. Usually, it is desirable to take 5,000 to 7,000 mg as an arginine-containing composition and 1,500 to 2,000 mg as a proanthocyanidin-containing composition per day for an adult. This amount is preferably taken once to several times a day, and most preferably taken twice a day. Since the oral composition of this embodiment can express the improvement effect of a sexual function faster, as an intake period may be shorter than before, for example, 2 weeks or more are desirable. Moreover, in order to maintain the outstanding improvement effect more, it is more desirable to ingest for one month or more. In addition, since it contains no hormones or the like and contains components that are commercially available as functional foods, it can be ingested for a long period of time, and can be ingested for several months or more.

  EXAMPLES Hereinafter, although an Example and a test example are given and this invention is demonstrated further more concretely, these are only illustrations and do not limit this invention.

Example 1
1. Preparation of Arginine-Containing Composition After the raw materials shown in Table 1 below were weighed and mixed using an existing mixing device, granules of the arginine-containing composition were prepared using an existing granulating device. Subsequently, this granule was packaged using an existing filling and packaging apparatus so as to have an amount as shown in Table 1 below. In this embodiment, the stick is packaged (packaging form in which the packaging material is filled in the form of a stick) and is used as a so-called stick granule, so that the product can be slimmed and simplified, etc. Easy to carry and ingest. The amount of each composition for one stick granule and the amount of each composition for two sticks as a guide for daily intake are shown in Table 1 below.

2. Preparation of proanthocyanidin-containing composition The raw materials shown in Table 2 below were weighed and mixed using an existing mixing device to prepare a proanthocyanidin-containing composition. Next, the hard capsule (No. 2) was filled with the proanthocyanidin-containing composition of the amount shown in Table 2 below using an existing capsule filling device to obtain a hard capsule. Table 2 below shows the amount of each composition for one hard capsule and the amount of each composition for six capsules as a guide for daily intake.

  The oral composition of Example 1 was made up of the above-mentioned arginine-containing composition stick granule and the proanthocyanidin-containing composition hard capsule. Also, by dividing the daily intake of granules into two instead of one, and dividing the daily intake of hard capsules into six instead of one, according to symptoms, improvement purpose, intake time, etc. Thus, it is possible to adjust the intake amount as appropriate.

3. Testosterone blood concentration change test The oral composition of Example 1 was administered to 10 male subjects, and changes in blood testosterone concentration were observed. The daily intake was as shown in Tables 1 and 2, and one arginine-containing composition (stick granule) and three proanthocyanidin-containing compositions (hard capsules) were taken twice a day.

  Table 3 below shows the measurement results of the blood testosterone blood concentration before ingestion of the oral composition by blood test and the blood testosterone blood concentration after ingestion of the oral composition continuously for one month.

  As shown in Table 3 above, ingestion of the oral composition of Example 1 increased the testosterone blood concentration in 7 out of 10 patients after 1 month. The increase in testosterone showed an improvement in the sexual function of the subject and an improvement in sexual functions such as erectile dysfunction. From this result, it was found that the oral composition of Example 1 was able to exhibit an excellent improvement effect such as male sexual function faster and more effectively. In addition, according to the blood test, the blood testosterone concentration increased, but the test results such as liver function and kidney function were almost unchanged, and the liver function and kidney function were ingested by ingestion of the oral composition of Example 1. It has also been found that etc. are not affected.

  As mentioned above, although the oral composition of this invention has been demonstrated based on embodiment and an Example, as for a concrete structure, it is not restricted to this embodiment and an Example, Each claim of a claim Design changes and additions are permitted without departing from the spirit of the invention according to the paragraph.

Claims (5)

An arginine-containing composition comprising arginine, sodium aspartate, and citrulline;
An oral composition comprising proanthocyanidins and a proanthocyanidin-containing composition containing zinc.   The oral composition according to claim 1, wherein the arginine-containing composition further contains at least one selected from vitamin C, vitamin E, and folic acid.   The oral composition according to claim 1 or 2, wherein the proanthocyanidin-containing composition further contains at least one selected from creatine, tonkat ant extract, coenzyme Q10, vitamin B6, and vitamin B12.   The oral composition according to any one of claims 1 to 3, wherein the arginine-containing composition is a granule, and the proanthocyanidin-containing composition is a capsule or a tablet.   The oral composition as described in any one of Claims 1-4 used for improvement of a sexual function.