JP2018049008A - Automatic analyzer - Google Patents

Abstract

An automatic analyzer capable of promptly performing an inspection is provided.
An automatic analyzer includes a reagent store, a reagent storage unit, and a probe. The reagent store stores the first reagent container 13a. The reagent storage unit is provided apart from the reagent storage, and can place the second reagent container 13b. The probe sucks the reagent contained in the first reagent container at the first position located on the reagent storage, and the reagent contained in the second reagent container at the second position located on the reagent storage unit And the reagent sucked from the first reagent container or the second reagent container is discharged to the reaction container 19 at the third position.
[Selection] Figure 7

Description

  Embodiments described herein relate generally to an automatic analyzer that dispenses a sample and a reagent such as blood and urine collected from a subject and measures a mixed solution of the dispensed sample and reagent.

  The automatic analyzer is intended for biochemical test items, immunological test items, and the like, and optically measures changes in color tone and turbidity caused by the reaction of a mixture of a sample collected from a specimen and a reagent for each test item. By this measurement, analysis data represented by the concentration of each test item component contained in the sample, the activity of the enzyme, and the like are generated.

  This automatic analyzer includes a reagent container that can store a large number of reagent containers containing reagents for each test item, and a reagent dispensing that dispenses the reagents in each reagent container stored in the reagent container into a reaction container. And a probe. Then, the reagent of the inspection item selected according to the inspection from among a large number of inspection items is dispensed into the reaction container, and the mixed solution of the sample and the reagent in the reaction container is measured to generate analysis data. If the reagent in the reagent container is reduced due to dispensing, it is necessary to replace the reagent container with a sufficiently stored reagent of the same inspection item as that reagent before the reagent runs short.

JP 2008-216173 A

  However, when the reagent dispensing probe is performing dispensing operation, if you try to store the reagent container containing the reagent for replenishment in the reagent store, the reagent dispensing probe will be used to avoid contact with or collision with the reagent dispensing probe. It is necessary to temporarily stop the dispensing operation. When the dispensing operation of the reagent dispensing probe is stopped, there is a problem that it takes time for the inspection.

  The embodiment has been made to solve the above-described problems, and an object thereof is to provide an automatic analyzer that can quickly perform an inspection.

  According to the embodiment, the automatic analyzer includes a reagent store, a reagent storage unit, and a probe. The reagent store stores the first reagent container. The reagent storage unit is provided apart from the reagent storage, and can place the second reagent container. The probe sucks the reagent contained in the first reagent container at the first position located on the reagent storage, and puts the reagent into the second reagent container at the second position located on the reagent storage unit. The reagent accommodated is aspirated, and the reagent aspirated from the first reagent container or the second reagent container is discharged to the reaction container at the third position.

The block diagram which shows the structure of the automatic analyzer which concerns on embodiment. The perspective view which shows the structure of the analysis part which concerns on embodiment. The figure which shows the external appearance of the 1st reagent container which concerns on embodiment. The figure which shows the external appearance of the 1st reagent dispensing probe and 1st reagent dispensing arm which concern on embodiment. The top view which shows an example of arrangement | positioning of each unit regarding the dispensing of the 1st and 2nd reagent of the analysis part which concerns on embodiment. The figure which shows the 1st reagent storage chamber which concerns on embodiment. The figure which shows an example of the track | orbit of the 1st reagent dispensing probe which concerns on embodiment. The figure which shows an example of the track | orbit of the 2nd reagent dispensing probe which concerns on embodiment.

  Hereinafter, embodiments will be described with reference to the drawings.

  FIG. 1 is a block diagram illustrating a configuration of an automatic analyzer according to the embodiment. The automatic analyzer 100 includes an analysis mechanism 10, a drive mechanism 40, an analysis control circuit 41, a data processing circuit 60, an output interface 70, an input interface 80, and a system control circuit 90.

  The analysis mechanism 10 measures a standard sample and / or test data by measuring a standard sample of each test item and / or a mixture of a sample such as a test sample collected from the test sample and a reagent of each test item. Is generated. The analysis mechanism 10 includes a plurality of units that perform sample dispensing, reagent dispensing, and the like. Dispensing the sample is, for example, sucking a predetermined sample from a predetermined sample container and discharging the sucked sample to a predetermined reaction container. The reagent dispensing is, for example, sucking a predetermined reagent from a predetermined reagent container and discharging the sucked reagent to a predetermined reaction container.

  The drive mechanism 40 drives a plurality of units constituting the analysis mechanism 10. The analysis control circuit 41 controls the drive mechanism 40 to operate each unit of the analysis mechanism 10.

  The data processing circuit 60 processes the standard data generated by the analysis mechanism 10 to generate calibration data for each inspection item. Further, the data processing circuit 60 processes the test data and the calibration data of the test items corresponding to the test data to generate analysis data of each test item. The output interface 70 prints out and displays the calibration data and / or analysis data generated by the data processing circuit 60.

  The input interface 80 is an input for setting analysis parameters such as the amount of sample and reagent to be dispensed for each inspection item, an input for executing calibration for generating calibration data, an input for executing a test for generating analysis data, etc. Accept.

  The system control circuit 90 controls the analysis control circuit 41, the data processing circuit 60, and the output interface 70.

  FIG. 2 is a perspective view showing the configuration of the analysis mechanism 10. The analysis mechanism 10 includes a sample disk 12, a first reagent storage 14, a second reagent storage 15, a first reagent rack 16a, a second reagent rack 16b, a first reagent storage chamber 17, and a second reagent storage chamber 18. ing.

  The sample disk 12 holds a plurality of sample containers 11. The sample container 11 accommodates each sample such as a standard sample for each inspection item, a test sample, and a quality control sample for performing quality control.

  The first reagent storage 14 stores a plurality of first reagent containers 13a, and keeps the reagents of each test item stored in the first reagent container 13a cold. The second reagent storage 15 stores a plurality of second reagent containers 13b and keeps the reagents of the respective inspection items stored in the second reagent containers 13b cold.

  The 1st reagent rack 16a is arrange | positioned in the 1st reagent store 14, and hold | maintains the several 1st reagent container 13a stored in the 1st reagent store 14 so that a movement is possible. The second reagent rack 16b is arranged in the second reagent storage 15 and holds a plurality of second reagent containers 13b stored in the second reagent storage 15 so as to be movable.

  The first reagent storage chamber 17 can be loaded with the first reagent container 13a. The second reagent storage chamber 18 can be loaded with the second reagent container 13b.

  The analysis mechanism 10 includes a plurality of reaction vessels 19 arranged on the circumference, and a reaction disk 20 that holds the reaction vessels 19 so as to be rotatable.

  The first reagent container 13a held in the first reagent rack 16a and the first reagent container 13a placed in the first reagent storage chamber 17 have components that react with the components of each test item included in each sample. For example, the first reagent system and the first reagent system containing two reagents are contained. In addition, the second reagent container 13b held in the second reagent rack 16b and the second reagent container 13b placed in the second reagent storage chamber 18 store the second reagent paired with the first reagent of the two reagent system. Accommodate.

  The analysis mechanism 10 includes a sample dispensing probe 21 and a sample dispensing arm 22. The sample dispensing probe 21 sucks each sample in the sample container 11 held on the sample disk 12 for each inspection item and discharges the sample into the reaction container 19. The sample dispensing arm 22 supports the sample dispensing probe 21 so as to be rotatable and vertically movable.

  The analysis mechanism 10 includes a first reagent dispensing probe 23 and a first reagent dispensing arm 24. The first reagent dispensing probe 23 is either the first reagent container 13 a held in the first reagent rack 16 a or the first reagent container 13 a placed in the first reagent storage chamber 17. The first reagent is aspirated and discharged into the reaction container 19 containing the sample. The first reagent dispensing arm 24 supports the first reagent dispensing probe 23 so as to be rotatable and vertically movable.

  The analysis mechanism 10 includes a first stirring bar 25 and a first stirring arm 26. The first stirring bar 25 stirs the mixed solution of the sample and the first reagent dispensed in the reaction container 19. The 1st stirring arm 26 supports the 1st stirring element 25 so that rotation and a vertical movement are possible.

  The analysis mechanism 10 includes a second reagent dispensing probe 27 and a second reagent dispensing arm 28. The second reagent dispensing probe 27 is either one of the second reagent container 13b held in the second reagent rack 16b or the second reagent container 13b placed in the second reagent storage chamber 18 and the second reagent container 13b. The second reagent inside is aspirated and discharged into the reaction container 19 containing the first reagent. The second reagent dispensing arm 28 supports the second reagent dispensing probe 27 so as to be rotatable and vertically movable.

  Further, the analysis mechanism 10 includes a second stirring bar 29 and a second stirring arm 30. The second stirrer 29 stirs the mixed solution of the sample, the first reagent, and the second reagent accommodated in the reaction container 19. The 2nd stirring arm 30 supports the 2nd stirring element 29 so that rotation and a vertical movement are possible.

  The analysis mechanism 10 includes a measurement unit 31 and a cleaning nozzle 32.

  The measuring unit 31 is provided in the vicinity of the photometric position. The photometric position is preset in the reaction disk 20. The measurement unit 31 irradiates light to the reaction container 19 that contains the mixed liquid stirred in the first stirrer 25 and / or the reaction container 19 that contains the mixed liquid stirred in the second stirrer 29. Measure optically. The measurement unit 31 includes a light source and a photodetector. The light source is, for example, an LED (Light Emitting Diode). The light source and the light detector are provided at positions facing each other across the reaction container 19 located at the photometric position. The measurement unit 31 emits light from the light source according to the control of the analysis control circuit 41. The photodetector detects the light emitted from the light source, for example, at a sampling period synchronized with the cycle time. Thereby, the light transmitted through the mixed liquid discharged to the reaction container 19 is detected.

  The measuring unit 31 irradiates light to the reaction container 19 that is rotating from the light source. The measurement unit 31 detects, by a light detector, light that has passed through each of the mixed solution including the standard sample in the reaction vessel 19, the mixed solution including the test sample, and the mixed solution including the quality control sample. To do. Then, the measurement unit 31 generates each data of standard data represented by absorbance, test data, and quality control data based on the detected signal, and outputs the data to the data processing circuit 60.

  The cleaning nozzle 32 cleans the reaction container 19 that has been measured by the measuring unit 31.

  Although not shown, the analysis mechanism 10 includes a first reagent liquid level detector and a second reagent liquid level detector. The first reagent liquid level detector is placed in the first reagent in the first reagent container 13a held in the lower end of the first reagent dispensing probe 23 and the first reagent rack 16a or in the first reagent storage chamber 17. The liquid level of the first reagent in the first reagent container 13a is detected by contact with the liquid level of the first reagent in the first reagent container 13a. The second reagent level detector is placed in the second reagent in the second reagent container 13b held in the lower end of the second reagent dispensing probe 27 and the second reagent rack 16b or in the second reagent storage chamber 18. The liquid level of the second reagent in the second reagent container 13b is detected by contact with the liquid level of the second reagent in the second reagent container 13b.

  The drive mechanism 40 shown in FIG. 1 drives the sample disk 12 of the analysis mechanism 10 to rotate each sample container 11. The drive mechanism 40 drives the first reagent rack 16a to rotate each first reagent container 13a. The drive mechanism 40 drives the second reagent rack 16b to rotate the second reagent containers 13b. Further, the drive mechanism 40 drives the reaction disk 20 to rotate and move each reaction vessel 19. The drive mechanism 40 has a mechanism for rotating and vertically moving the sample dispensing arm 22, and moves the sample dispensing probe 21 between the sample container 11 and the reaction container 19.

  Further, the drive mechanism 40 includes a rotation mechanism that rotates the first reagent dispensing arm 24 and a vertical movement mechanism that moves the first reagent dispensing arm 24 up and down. The drive mechanism 40 moves the first reagent dispensing probe 23 to either the first reagent container 13a held in the first reagent rack 16a or the first reagent container 13a placed in the first reagent storage chamber 17. It is moved between the first reagent container 13a and the reaction container 19. Further, the drive mechanism 40 drives the first stirring arm 26 to move the first stirring bar 25 into the reaction vessel 19.

  Further, the drive mechanism 40 includes a rotation mechanism that rotates the second reagent dispensing arm 28 and a vertical movement mechanism that moves the second reagent dispensing arm 28 up and down. The drive mechanism 40 moves the second reagent dispensing probe 27 to either the second reagent container 13b held in the second reagent rack 16b or the second reagent container 13b placed in the second reagent storage chamber 18. It is moved between the second reagent container 13b and the reaction container 19. Further, the drive mechanism 40 drives the second stirring arm 30 to move the second stirring bar 29 into the reaction vessel 19.

  The analysis control circuit 41 includes a processor and a storage circuit. When an input for executing calibration is performed from the input interface 80, the analysis control circuit 41 controls the drive mechanism 40, operates the cleaning nozzle 32, and cleans each reaction container 19. Further, the analysis control circuit 41 controls the drive mechanism 40 to operate the sample dispensing probe 21 and the sample dispensing arm 22 to perform suction and discharge of the standard sample for each inspection item. The analysis control circuit 41 also controls the drive mechanism 40 to operate the first reagent dispensing probe 23 and the first reagent dispensing arm 24 to perform suction and discharge of the first reagent for each inspection item. Moreover, the analysis control circuit 41 controls the drive mechanism 40, operates the first stirring bar 25 and the first stirring arm 26, and stirs the mixture of the standard sample and the first reagent for each test item. In addition, the analysis control circuit 41 controls the drive mechanism 40 to operate the second reagent dispensing probe 27 and the second reagent dispensing arm 28 to perform suction and discharge of the second reagent for each inspection item. Further, the analysis control circuit 41 controls the drive mechanism 40 to operate the second stirrer 29 and the second stirring arm 30 to stir the mixed sample of the standard sample, the first reagent, and the second reagent for each inspection item. . Moreover, the analysis control circuit 41 controls the drive mechanism 40, operates the measurement part 31, and measures the liquid mixture of the standard sample of each test item, a 1st reagent, and a 2nd reagent. Thereby, standard data of each inspection item is generated.

  The analysis control circuit 41 causes each unit of the analysis mechanism 10 to perform the above operations for each cycle, and generates standard data for each inspection item.

  In addition, after the calibration is completed, the analysis control circuit 41 controls the drive mechanism 40 and activates the cleaning nozzle 32 to clean each reaction container 19 when an input for executing an inspection is performed from the input interface 80. . Further, the analysis control circuit 41 controls the drive mechanism 40 to operate the sample dispensing probe 21 and the sample dispensing arm 22 to suck and discharge each test sample and / or quality control sample. The analysis control circuit 41 also controls the drive mechanism 40 to operate the first reagent dispensing probe 23 and the first reagent dispensing arm 24 to perform suction and discharge of the first reagent for each inspection item. Further, the analysis control circuit 41 controls the drive mechanism 40 to operate the first stirrer 25 and the first stirrer arm 26 to mix the test sample and the first reagent of each test item, and / or accuracy. The liquid mixture of the control sample and the first reagent of each inspection item is stirred. In addition, the analysis control circuit 41 controls the drive mechanism 40 to operate the second reagent dispensing probe 27 and the second reagent dispensing arm 28 to perform suction and discharge of the second reagent for each inspection item. The analysis control circuit 41 also controls the drive mechanism 40 to operate the second stirrer 29 and the second stirring arm 30, so that the test sample, the mixed solution of the first reagent and the second reagent of each test item, and Or, the mixed solution of the quality control sample, the first reagent and the second reagent of each inspection item is stirred. Further, the analysis control circuit 41 controls the drive mechanism 40 to operate the measurement unit 31, and the sample to be agitated, the mixed solution of the first reagent and the second reagent of each inspection item, and / or accuracy management. A sample and a mixed solution of the first reagent and the second reagent of each inspection item are measured. Thereby, test data and / or quality control data for each inspection item is generated.

  The analysis control circuit 41 causes each unit of the analysis mechanism 10 to perform the above operations for each cycle, and generates test data and / or quality control data for each inspection item.

  Further, the analysis control circuit 41 supplies a drive pulse to the rotation mechanism of the first reagent dispensing arm 24 in the drive mechanism 40. The analysis control circuit 41 then moves the first reagent dispensing probe 23 to move the first reagent container 13a placed above the first reagent container 13a held in the first reagent rack 16a and in the first reagent storage chamber 17. It stops at each upper stop position above 13a and above the reaction vessel 19. Further, the analysis control circuit 41 supplies a drive pulse to the vertical mechanism of the first reagent dispensing arm 24 to lower the first reagent dispensing probe 23 from each upper stop position. Then, the analysis control circuit 41 uses the first reagent dispensing probe 23 lowered from the upper stop position of the first reagent container 13a as the first reagent liquid level detector, and the liquid of the first reagent in the first reagent container 13a. After stopping at the position where the surface is detected, the first reagent in the first reagent container 13a is aspirated.

  Further, the analysis control circuit 41 supplies a drive pulse to the rotation mechanism of the second reagent dispensing arm 28. Then, the analysis control circuit 41 moves the second reagent dispensing probe 27 to move the second reagent container placed in the second reagent storage chamber 18 above the second reagent container 13b held in the second reagent rack 16b. It stops at each upper stop position above 13b and above the reaction vessel 19. Further, the analysis control circuit 41 supplies a drive pulse to the vertical mechanism of the second reagent dispensing arm 28, and lowers the second reagent dispensing probe 27 from each upper stop position. Then, the analysis control circuit 41 uses the second reagent dispensing probe 27 lowered from the upper stop position of the second reagent container 13b as the second reagent liquid level detector, and the second reagent liquid in the second reagent container 13b. After stopping at the position where the surface is detected, the second reagent in the second reagent container 13b is aspirated.

  Further, the analysis control circuit 41 detects from the preset dimensions of the first reagent container 13a, the height of the first reagent container 13a held in the first reagent rack 16a, and the upper stop position of the first reagent rack 16a. Based on the number of drive pulses required to lower the first reagent dispensing probe 23 to the position, the amount of the first reagent in each first reagent container 13a held in the first reagent rack 16a is calculated. In addition, the analysis control circuit 41 starts from the height of the first reagent container 13 a placed in the first reagent storage chamber 17 and the upper stop position of the first reagent container 13 a placed in the first reagent storage chamber 17. Based on the number of drive pulses required for lowering the first reagent dispensing probe 23 to the detection position, the amount of the first reagent in each first reagent container 13a placed in the first reagent storage chamber 17 is calculated.

  Then, when the calculated amount of the first reagent in each first reagent container 13a decreases and the number of dispenseable times reaches an amount corresponding to a preset number of warnings, the analysis control circuit 41 The reagent information of one reagent and a message warning that the first reagent is insufficient are output from the output interface 70.

  Further, the analysis control circuit 41 detects from the preset size of the second reagent container 13b, the height of the second reagent container 13b held in the second reagent rack 16b, and the upper stop position of the second reagent rack 16b. Based on the number of drive pulses required to lower the second reagent dispensing probe 27 to the position, the amount of the second reagent in each second reagent container 13b held in the second reagent rack 16b is calculated. The analysis control circuit 41 also includes the height of the second reagent container 13b placed in the second reagent storage chamber 18, and the upper stop position of each second reagent container 13b placed in the second reagent storage chamber 18. The amount of the second reagent in each second reagent container 13b placed in the second reagent storage chamber 18 is calculated based on the number of drive pulses required for the second reagent dispensing probe 27 to descend from the detection position to the detection position. .

  When the amount of the second reagent in the calculated second reagent container 13b decreases and the number of dispenseable times reaches an amount corresponding to a preset number of warnings, the analysis control circuit 41 The output interface 70 outputs the reagent information of the two reagents and a message warning that the second reagent is insufficient.

  The data processing circuit 60 includes a memory 62. For example, the data processing circuit 60 executes the operation program read from the memory 62, thereby realizing the arithmetic function 61 shown in FIG. That is, the data processing circuit 60 includes a calculation function 61. By executing the calculation function 61, the data processing circuit 60 determines the relationship between the standard value and the standard data from the standard data generated by the measurement unit 31 of the analysis mechanism 10 and the standard value set for the standard sample of the standard data. Calibration data for each inspection item shown is generated. Further, the data processing circuit 60 generates analysis data expressed as a concentration value or an activity value from the test data generated by the measurement unit 31 using the calibration data of the test item corresponding to the test data. Further, the data processing circuit 60 generates quality control sample data expressed as a concentration value or an activity value from the quality control data generated by the measurement unit 31 using calibration data of the inspection item corresponding to the quality control data. To do. The memory 62 includes a memory device such as a hard disk, and stores calibration data and quality control sample data generated by the data processing circuit 60 for each inspection item. Further, the memory 62 stores analysis data of each inspection item generated by the data processing circuit 60 for each test sample.

  The output interface 70 includes a printer 71 and a monitor 72. The printer 71 prints out standard data, analysis data, quality control sample data, and the like generated by the data processing circuit 60. The monitor 72 displays and outputs standard data, analysis data, quality control sample data, etc. generated by the data processing circuit 60. The printer 71 includes a printer or the like, and prints out calibration data, analysis data, and quality control sample data on printer paper or the like according to a preset format.

  The monitor 72 includes a monitor such as a CRT or a liquid crystal panel, and the amount of sample necessary for measurement of each inspection item, the amount of the first reagent of the first reagent system and the second reagent system, the amount of the second reagent of the second reagent system, etc. Displays a screen for setting analysis parameters. In addition, the monitor 72 displays a screen for setting inspection items for executing calibration. The monitor 72 displays a screen for setting identification information such as a name and ID for identifying a test sample to be inspected and an inspection item. The monitor 72 displays calibration data, analysis data, and quality control sample data. In addition, the monitor 72 displays the reagent information of the first reagent in each first reagent container 13a that has reached the amount corresponding to the number of warnings and the message that warns that the first reagent is insufficient. The monitor 72 displays the reagent information of the second reagent in each second reagent container 13b in which the number of dispenseable times has reached the amount corresponding to the number of warnings and a message warning the second reagent shortage.

  The input interface 80 includes input devices such as a keyboard, a mouse, a button, and a touch key panel, and performs input for setting analysis parameters for each inspection item. Further, the input interface 80 receives an input for setting an inspection item for executing calibration. The input interface 80 accepts input for setting identification information and inspection items of a sample to be inspected. It also accepts input for executing calibration, inspection, and the like.

  The system control circuit 90 includes a processor and a storage circuit. The system control circuit 90 stores input information such as analysis parameter information, identification information, and inspection items of each inspection item input from the input interface 80 in a storage circuit. The system control circuit 90 controls the entire system by supervising the analysis control circuit 41, the data processing circuit 60, and the output interface 70 based on the input information.

  Next, the first reagent container 13a, the first reagent dispensing probe 23, the first reagent dispensing arm 24, the first reagent storage 14, and the first reagent storage chamber related to the suction and discharge of the first reagent of the analysis mechanism 10 17 and the second reagent container 13b, the second reagent dispensing probe 27, the second reagent dispensing arm 28, the second reagent storage 15, and the second reagent storage related to the suction and discharge of the second reagent. The configuration and operation of the chamber 18 will be described in detail.

  FIG. 3 is a view showing the appearance of the first reagent container 13a. The first reagent container 13a has a quadrangular prism shape, and has an opening 131a into which the first reagent dispensing probe 23 enters near one end in the longitudinal direction of the upper surface. The first reagent in the first reagent container 13a is identified on the side face of the four side faces forming the first reagent container 13a with the short side in the vicinity of the rectangular opening forming the upper surface as one side. Reagent information such as inspection items is written in a barcode, for example. Since the second reagent container 13b is configured in the same manner as the first reagent container 13a, the description thereof is omitted.

  FIG. 4 is a view showing the external appearance of the first reagent dispensing probe 23 and the first reagent dispensing arm 24. The first reagent dispensing probe 23 has a tubular shape, and has an opening at the lower end for sucking and discharging the first reagent. The upper end portion is supported by the first reagent dispensing arm 24. The first reagent dispensing arm 24 has a shaft 241 that is rotated and driven up and down by the drive mechanism 40, one end fixed to the upper end of the shaft 241, and the other end supporting the first reagent dispensing probe 23. And an arm 242. Note that the second reagent dispensing probe 27 and the second reagent dispensing arm 28 are configured in the same manner as the first reagent dispensing probe 23 and the first reagent dispensing arm 24, and thus description thereof is omitted.

  FIG. 5 is a plan view showing an example of the arrangement of units related to the dispensing of the first and second reagents of the analysis mechanism 10.

  The first reagent store 14 includes a reader 141 and a reagent cover 142. The reader 141 reads the reagent information written in the first reagent container 13a held in the first reagent rack 16a. The reagent cover 142 covers an opening provided in the upper part of the first reagent storage 14 so as to be freely opened and closed. The first reagent container 13a is taken in and out from the first reagent storage 14 through this opening. The opening of the first reagent storage 14 is provided with a reagent cover 142 to keep the first reagent in each first reagent container 13a held in the first reagent rack 16a cool, except when the first reagent container 13a is taken in and out. Is blocked. The reagent cover 142 is provided with a through-hole 143 into which the lowered first reagent dispensing probe 23 enters at a position above the first reagent container 13a at the suction position A1.

  The first reagent storage chamber 17 is disposed away from the first reagent storage 14, the second reagent storage 15, and the second reagent storage chamber 18. The first reagent storage chamber 17 is arranged so that a predetermined number of first reagent containers 13a can be placed thereon. The predetermined number is smaller than the number of first reagent containers 13a that can be held in the first reagent rack 16a arranged in the first reagent storage 14. As shown in FIG. 5, the predetermined number is 3, for example.

  A placement surface 175 is provided on the bottom surface of the first reagent storage chamber 17. The placement surface 175 is a surface on which the first reagent container 13a can be placed. The placement surface 175 is a part of the analysis mechanism 10. The mounting surface 175 is provided a predetermined distance below the upper surface of the analysis mechanism 10. The distance from the top surface of the analysis mechanism 10 to the placement surface 175 is, for example, greater than the distance from the bottom surface of the first reagent container 13a to the opening 131a.

  The first reagent storage chamber 17 is provided with a first side surface 176, a second side surface 177, and a third side surface 178 so as to rise from the outer peripheral end of the placement surface 175. The first side 176, the second side 177, and the third side 178 are part of the analysis mechanism 10.

  The first reagent storage chamber 17 includes a reagent cover 173 at a position facing the placement surface 175. The reagent cover 173 covers the upper part of all the first reagent containers 13a placed on the placement surface 175. The reagent cover 173 is provided substantially flush with the upper surface of the analysis mechanism 10. The reagent cover 173 has three through-holes so that the first reagent dispensing probe 23 can descend from above and enter the three first reagent containers 13a placed at predetermined positions. 174 is provided.

  As shown in FIGS. 5 and 6, the first reagent storage chamber 17 is formed by the placement surface 175, the first side surface 176, the second side surface 177, the third side surface 178, and the reagent cover 173. Yes.

  Although not shown, the first reagent storage chamber 17 includes a Peltier element or the like, and can cool the first reagent in the placed first reagent container 13a.

  An intake port 17 a is provided on one surface of the first reagent storage chamber 17. As shown in FIG. 2, the intake port 17 a is provided on the side portion on the front side of the analysis mechanism 10. Then, in the first reagent storage chamber 17, as shown in FIG. 6, the first reagent container 13a with the side surface where the barcode is written is directed to the front side of the analysis mechanism 10 is taken horizontally from the inlet 17a in the direction of the arrow L1. For example, three first reagent containers 13a can be placed at predetermined positions by pushing them in until they come into contact with the detector 171.

  The first reagent storage chamber 17 includes a detector 171 and a reader 172.

  The detector 171 detects each first reagent container 13a by contacting the side surface on which the barcode of the first reagent container 13a is abutted. The reader 172 reads the reagent information written in the first reagent container 13a detected by the detector 171.

  In this way, by pushing in the L1 direction to the position where it abuts on the detector 171, each first reagent container 13a can be placed at a predetermined position where the first reagent dispensing probe 23 can enter.

  Then, in the first reagent storage chamber 17, the first reagent container 13a containing the first reagent of the inspection item is stored so that the first reagent rack 13a is not normally held in the first reagent rack 16a because the inspection frequency is low. Is placed. Further, in the first reagent storage chamber 17, the first reagent in the first reagent container 13a held in the first reagent rack 16a is equal to or less than the amount corresponding to the preset number of warnings, that is, preset. The first reagent container 13a containing the first reagent of the same inspection item as the first reagent container 13a reduced to the amount or less is placed.

  As shown in FIG. 7A, the first reagent dispensing arm 24 indicates an arc on a circumference T1 with the first upper stop position P1 and the second upper stop position P2 at both ends, as indicated by arrows. The first trajectory T11 is used to support the first reagent dispensing probe 23 so as to be horizontally movable along the first trajectory T11. The first upper stop position P1 is located above the first reagent container 13a at the suction position A1 held by the first reagent rack 16a. The second upper stop position P2 is located above the reaction container 19 at the discharge position D1.

  Further, as shown in FIG. 7A, the first reagent dispensing arm 24 can lower the first reagent dispensing probe 23 from each of the first upper stop position P1 and the second upper stop position P2. To support.

  Further, as shown in FIG. 7B, the first reagent dispensing arm 24 is along a second trajectory T12 having both the third upper stop position P3 and the second upper stop position P2 as both ends. The first reagent dispensing probe 23 is supported so as to be horizontally movable. The third upper stop position P3 is above the three first reagent containers 13a placed at predetermined positions in the first reagent storage chamber 17, and is on an extension line of the first trajectory T11 on the circumference T1. Located in. The second trajectory T12 is represented by an arc on the circumference T1.

  Further, as shown in FIG. 7B, the first reagent dispensing arm 24 can lower the first reagent dispensing probe 23 from each of the second upper stop position P2 and the third upper stop position P3. To support.

  In FIG. 7B, the second trajectory T12 is a trajectory on the dominant arc side on the circumference T1 including the first trajectory T11. However, the third upper stop position P3 and the second upper stop position are the same. The inferior arc side not including the second trajectory T12 having P2 as both ends on the circumference T1 may be used as the trajectory. At this time, the first reagent dispensing arm 24 supports the first reagent dispensing probe 23 so as to be horizontally movable along the track on the inferior arc side. Further, the trajectory of the first reagent dispensing probe 23 is not limited to the trajectory that draws a circle, and may be a trajectory that draws an arbitrary curve.

  The first reagent dispensing probe 23 is moved to the suction position A1 among the plurality of first reagent containers 13a held in the first reagent rack 16a for each cycle under the control of the analysis control circuit 41. Dispensing the first reagent in the first reagent container 13a of the inspection item. The first reagent dispensing probe 23 has a predetermined position on the first trajectory T11 as a basic position, moves horizontally along the first trajectory T11 from the basic position, and stops at the first upper stop position P1. . Next, the first reagent dispensing probe 23 descends from the first upper stop position P1, and the position where the liquid level of the first reagent in the first reagent container 13a at the suction position A1 is detected by the first reagent detector. Stop at. The first reagent dispensing probe 23 aspirates the first reagent at the stop position, then moves upward and stops at the first upper stop position P1, and then moves horizontally along the first trajectory T11. Stop at the second upper stop position P2. Next, the first reagent dispensing probe 23 moves horizontally to the basic position along the first trajectory T11 after discharging the first reagent into the reaction container 19 at the discharge position D1 at the second upper stop position P2. To do. The first reagent dispensing probe 23 performs each of the operations so far during one cycle.

  Further, the first reagent dispensing probe 23 takes the basic position on the first trajectory T11 as the basic position of the second trajectory T12 under the control of the analysis control circuit 41, and follows the second trajectory T12 from the basic position. Move horizontally. Then, the first reagent dispensing probe 23 stops at the third upper stop position P3 above the first reagent container 13a at the position where the reagent information is read by the reader 172. Next, the first reagent dispensing probe 23 descends from the third upper stop position P3 and stops at the position where the liquid level of the first reagent in the first reagent container 13a is detected by the first reagent detector. The first reagent dispensing probe 23 ascends and stops at the third upper stop position P3 after aspirating the first reagent, moves horizontally along the second trajectory T12, and then moves to the second upper stop position P3. Stop at stop position P2. Next, the first reagent dispensing probe 23 moves horizontally to the basic position along the second trajectory T12 after discharging the first reagent into the reaction container 19 at the discharge position D1 at the second upper stop position P2. To do. The first reagent dispensing probe 23 performs one dispensing operation so far in one cycle.

  Of the three positions where the first reagent storage chamber 17 can be placed, the first reagent container 13a is not placed at a predetermined position and is not detected by the detector 171. The probe 23 is controlled so as not to descend.

  Thus, since the first reagent storage chamber 17 is disposed at a position away from the first track T11, the operator can obtain the first reagent dispensing probe 23 held in the first reagent rack 16a. When the first reagent in the reagent container 13a is being dispensed into the reaction container 19, the first reagent container 13a is not contacted or collided with the first reagent dispensing probe 23 or the first reagent dispensing arm 24. It can be placed in the first reagent storage chamber 17.

  Further, the second trajectory is disposed from the intake port 17a disposed on the outer peripheral side of the second trajectory T12 and disposed below the first reagent dispensing probe 23 moving along the second trajectory T12. The first reagent container 13a can be placed in the first reagent storage chamber 17 by being pushed in horizontally toward T12. Thereby, the first reagent dispensing probe 23 and the first reagent dispensing arm 24 moving along the second trajectory T12, the first reagent container 13a placed in the first reagent storage chamber 17, and the first reagent container 13a. Contact and collision with an operator having one reagent container 13a can be prevented.

  When the first reagent container 13a is placed at a predetermined position in the first reagent storage chamber 17, and the first reagent container 13a is additionally placed, the first reagent container 13a is removed from the inlet 17a through the first reagent container 13a. The first reagent dispensing probe 23 does not descend to the position of the additionally placed first reagent container 13a unless the reagent container 13a is horizontally pushed into a position where the reagent container 13a is not placed and placed at a predetermined position. Therefore, contact and collision between the first reagent container 13a and the first reagent dispensing probe 23 can be prevented.

  The second reagent storage 15 includes a reader 151 and a reagent cover 152. The reader 151 reads the reagent information written in the second reagent container 13b held in the second reagent rack 16b. The reagent cover 152 covers the opening provided in the upper part of the second reagent storage 15 so as to be freely opened and closed. The second reagent container 13b is taken in and out of the second reagent storage 15 through this opening. The opening of the second reagent storage 15 is provided with a reagent cover 152 for keeping the second reagent in each second reagent container 13b held in the second reagent rack 16b, except when the second reagent container 13b is taken in and out. Is blocked. The reagent cover 152 is provided with a through hole 153 into which the lowered second reagent dispensing probe 27 enters at a position above the second reagent container 13b in the suction position A2.

  The second reagent storage chamber 18 is arranged apart from the first reagent storage 14, the second reagent storage 15, and the first reagent storage chamber 17. The second reagent storage chamber 18 is arranged so that a predetermined number of second reagent containers 13b can be placed thereon. The predetermined number is smaller than the number of second reagent containers 13b that can be held by the second reagent rack 16b. As shown in FIG. 5, the predetermined number is 3, for example.

  A placement surface 185 is provided on the bottom surface of the second reagent storage chamber 18. The placement surface 185 is a surface on which the second reagent container 13b can be placed. The placement surface 185 is a part of the analysis mechanism 10. The placement surface 185 is provided below the upper surface of the analysis mechanism 10 by a predetermined distance. The distance from the top surface of the analysis mechanism 10 to the placement surface 185 is, for example, greater than the distance from the bottom surface of the second reagent container 13b to the opening.

  The second reagent storage chamber 18 is provided with a first side surface 186, a second side surface 187, and a third side surface 188 so as to rise from the outer peripheral end of the placement surface 185. The first side 186, the second side 187, and the third side 188 are part of the analysis mechanism 10.

  Further, the second reagent storage chamber 18 includes a reagent cover 183 at a position facing the placement surface 185. The reagent cover 183 covers the upper part of all the second reagent containers 13b placed on the placement surface 185. The reagent cover 183 is provided substantially flush with the upper surface of the analysis mechanism 10. The reagent cover 183 has three through-holes so that the second reagent dispensing probe 27 can descend from above and enter the three second reagent containers 13b placed at predetermined positions. 184 is provided.

  As shown in FIGS. 5 and 6, the second reagent storage chamber 18 is formed by the placement surface 185, the first side surface 186, the second side surface 187, the third side surface 188, and the reagent cover 183. Yes.

  In addition, although not shown in figure, the 2nd reagent storage chamber 18 is equipped with a Peltier device etc., and can cool the 2nd reagent in the mounted 2nd reagent container 13b.

  In addition, an inlet 18 a is provided on one surface of the second reagent storage chamber 18. The intake 18a is provided on the side of the analysis mechanism 10 on the back side. Then, the second reagent container 13b with the side surface on which the barcode is written is directed to the back side of the analysis mechanism 10 is pushed in horizontally in the direction of the arrow L2 from the inlet 18a and pushed to a position where it abuts on the detector 181. For example, three second reagent containers 13b can be placed at predetermined positions.

  The second reagent storage chamber 18 includes a detector 181 and a reader 182.

  The detector 181 detects each second reagent container 13b placed at a predetermined position by contacting the side surface on which the barcode of the second reagent container 13b is in contact. The reader 182 reads the reagent information recorded in the second reagent container 13b detected by the detector 181.

  In this way, each second reagent container 13b can be placed at a predetermined position where the second reagent dispensing probe 27 can enter by pushing in the L2 direction to a position where it abuts against the detector 181.

  Then, in the second reagent storage chamber 18, the second reagent container 13b containing the second reagent of the inspection item is stored so that the second reagent container 13b is not normally held in the second reagent rack 16b because the inspection frequency is low. Is placed. Further, in the second reagent storage chamber 18, the second reagent in the second reagent container 13b held in the second reagent rack 16b is equal to or less than the amount corresponding to the preset number of warnings, that is, preset. The second reagent container 13b in which the second reagent of the same inspection item as the second reagent container 13b decreased beyond the amount is placed.

  As shown in FIG. 8 (a), the second reagent dispensing arm 28 has an arc on a circumference T2 having a fourth upper stop position P4 and a fifth upper stop position P5 as both ends. The trajectory T21 is used to support the second reagent dispensing probe 27 so as to be horizontally movable along the third trajectory T21. The fourth upper stop position P4 is located above the second reagent container 13b at the suction position A2 held by the second reagent rack 16b. The fifth upper stop position P5 is located above the reaction container 19 at the discharge position D2.

  Further, as shown in FIG. 8A, the second reagent dispensing arm 28 can lower the second reagent dispensing probe 27 from the fourth upper stop position P4 and the fifth upper stop position P5. To support.

  Further, as shown in FIG. 8 (b), the second reagent dispensing arm 28 has a circular arc on the circumference T2 with the sixth upper stop position P6 and the fourth upper stop position P4 as both ends. The second reagent dispensing probe 27 is supported so as to be horizontally movable along the fourth track T22. The sixth upper stop position P6 is above the three second reagent containers 13b placed at predetermined positions in the second reagent storage chamber 18, and is on an extension line of the third trajectory T21 on the circumference T2. Located in.

  Further, as shown in FIG. 8B, the second reagent dispensing arm 28 can lower the second reagent dispensing probe 27 from the fifth upper stop position P5 and the sixth upper stop position P6. To support.

  In FIG. 8 (b), the fourth trajectory T22 is a trajectory on the dominant arc side on the circumference T2 including the third trajectory T21. However, the sixth upper stop position P6 and the fifth upper stop position are the same. The inferior arc side not including the fourth orbit T22 having P5 as both ends on the circumference T2 may be used as the orbit. At this time, the second reagent dispensing arm 28 supports the second reagent dispensing probe 27 so as to be horizontally movable along the track on the inferior arc side.

  The second reagent dispensing probe 27 is moved to the suction position A2 among the plurality of second reagent containers 13b held in the second reagent rack 16b every cycle under the control of the analysis control circuit 41. Dispensing the second reagent in the second reagent container 13b as the inspection item. The second reagent dispensing probe 27 has a predetermined position on the third trajectory T21 as a basic position, moves horizontally from the basic position along the third trajectory T21, and stops at a fourth upper stop position P4. . Next, the second reagent dispensing probe 27 descends from the fourth upper stop position P4, and the position at which the liquid level of the second reagent in the second reagent container 13b at the suction position A2 is detected by the second reagent detector. Stop at. The second reagent dispensing probe 27 ascends and stops at the fourth upper stop position P4 after aspirating the second reagent, and then moves horizontally along the third trajectory T21. Stop at stop position P5. Next, the second reagent dispensing probe 27 moves horizontally to the basic position along the third trajectory T21 after discharging the second reagent into the reaction container 19 at the discharge position D2 at the fifth upper stop position P5. To do. The second reagent dispensing probe 27 performs one dispensing operation so far during one cycle.

  In addition, the second reagent dispensing probe 27 takes the basic position on the third trajectory T21 as the basic position of the fourth trajectory T22 along the fourth trajectory T22 from the basic position under the control of the analysis control circuit 41. Move horizontally. Then, the second reagent dispensing probe 27 stops at the sixth upper stop position P6 above the second reagent container 13b at the position where the reagent information is read by the reader 182. Next, the second reagent dispensing probe 27 descends from the sixth upper stop position P6, and stops at the position where the liquid level of the second reagent in the second reagent container 13b is detected by the second reagent detector. The second reagent dispensing probe 27 ascends and stops at the sixth upper stop position P6 after aspirating the second reagent, moves horizontally along the fourth trajectory T22, and moves to the fifth upper stop position P6. Stop at stop position P5. Next, after the second reagent dispensing probe 27 discharges the second reagent into the reaction container 19 at the discharge position D2 at the fifth upper stop position P5, the second reagent dispensing probe 27 moves horizontally to the basic position along the fourth trajectory T22. To do. The second reagent dispensing probe 27 performs one dispensing operation so far in one cycle.

  Of the three positions where the second reagent storage chamber 18 can be placed, the second reagent container 13 b is not placed at a predetermined position and is not detected by the detector 181. The probe 27 is controlled so as not to descend.

  Thus, since the second reagent storage chamber 18 is disposed at a position away from the third track T21, the operator can use the second reagent dispensing probe 27 held by the second reagent rack 16b in the second reagent rack 16b. When the second reagent in the reagent container 13b is being dispensed into the reaction container 19, the second reagent container 13b is not contacted or collided with the second reagent dispensing probe 27 or the second reagent dispensing arm 28. Two reagent storage chambers 18 can be placed.

  Further, the fourth trajectory is arranged from the intake port 18a disposed on the outer peripheral side of the fourth trajectory T22 and disposed below the second reagent dispensing probe 27 moving along the fourth trajectory T22. The second reagent container 13b can be placed in the second reagent storage chamber 18 by being pushed in horizontally in the direction of T22. Thereby, the second reagent dispensing probe 27 and the second reagent dispensing arm 28 moving along the fourth trajectory T22, the second reagent container 13b placed in the second reagent storage chamber 18, and the second reagent container 13b are moved. It is possible to prevent contact and collision with the hand of the worker holding the two reagent containers 13b.

  When the second reagent container 13b is placed at a predetermined position in the second reagent storage chamber 18, and the second reagent container 13b is additionally placed, the second reagent container 13b is removed from the inlet 18a through the second inlet 18a. The second reagent dispensing probe 27 does not descend to the position of the additionally mounted second reagent container 13b unless the reagent container 13b is horizontally pushed into a position where the reagent container 13b is not placed and placed at a predetermined position. Therefore, contact and collision between the second reagent container 13b and the second reagent dispensing probe 27 can be prevented.

  Hereinafter, an example of the operation of the automatic analyzer 100 will be described with reference to FIGS. 1 to 8.

  When there is no space for the first reagent rack 16a to hold the first reagent container 13a in which the first reagent of the inspection item B with a low inspection frequency is stored, the first reagent container 13a of the inspection item B is the first reagent storage chamber. 17 at predetermined positions. Further, the second reagent container 13b in which the second reagent of the test item B is accommodated is also placed at a predetermined position in the second reagent storage chamber 18 for the same reason as the first reagent container 13a.

  When an input for executing calibration of each inspection item including the inspection item B is performed from the input interface 80, the automatic analyzer 100 starts a calibration operation. The analysis control circuit 41 rotates the first reagent rack 16a in the first reagent storage 14 and the second reagent rack 16b in the second reagent storage 15, respectively. The analysis control circuit 41 then sets the reagent information written in all the first reagent containers 13a held in each first reagent rack 16a and all the second reagent containers 13b held in the second reagent rack 16b. Are read by the reader 141 and the reader 151, respectively.

  The analysis control circuit 41 is placed at a predetermined position in the first reagent storage chamber 17 and the reagent information written in the first reagent container 13a of the inspection item B detected by the detector 171 and the second reagent storage. Reagent information written in the second reagent container 13b of the inspection item B placed at a predetermined position in the chamber 18 and detected by the detector 181 is read by the reader 172 and the reader 182, respectively. Then, the analysis control circuit 41 sets the reagent information and the holding position information of all the first reagent containers 13a held in the first reagent rack 16a, and all the second reagent containers held in the second reagent rack 16b. The reagent information 13b and the information on the holding position are acquired. The analysis control circuit 41 also includes reagent information and placement position information of all the first reagent containers 13a placed in the first reagent storage chamber 17, and all of the placements in the second reagent storage chamber 18. The reagent information and placement position information of the second reagent container 13b are acquired.

  If the acquired reagent information does not include reagent information of all the inspection items for which calibration is to be performed, each analysis reagent circuit 13a and second reagent container 13b of the inspection item is not included. An error message indicating that is not installed in the analysis mechanism 10 is displayed on the monitor 72. Further, when the analysis control circuit 41 is a two-reagent test item B, the first reagent container 13a of the test item B is placed in, for example, the first reagent storage chamber 17, and the second reagent container 13b of the test item B is placed. Is not held in the second reagent rack 16b and is not placed in the second reagent storage chamber 18, the monitor 72 indicates that the second reagent of the inspection item B is not installed in the analysis mechanism 10. An error message is displayed on the monitor 72. Further, the analysis control circuit 41 has the second reagent container 13b of the test item B placed in the second reagent storage chamber 18, and the first reagent container 13a of the test item B is not held in the first reagent rack 16a. If it is not placed in the first reagent storage chamber 17, an error message indicating that the first reagent of the inspection item B is not installed in the analysis mechanism 10 is displayed on the monitor 72. When calibration is executed in a state where one of the first reagent container 13a or the second reagent container 13b of the inspection item B is not installed in the analysis mechanism 10, the standard sample and the reagent of the inspection item B are The dispensing data is not dispensed, and the calibration data for the inspection item B is not generated.

  The analysis control circuit 41 cleans each reaction container 19, dispenses each standard sample, dispenses the first reagent for each inspection item, and agitates the mixture of each standard sample and the first reagent for each inspection item. And the dispensing of the second reagent for each inspection item, the stirring of the liquid mixture of each standard sample, the first reagent and the second reagent of each inspection item, and the measurement of the stirred liquid mixture are performed for each cycle. Make it.

  In dispensing the first reagent, the first reagent dispensing probe 23 aspirates the first reagent in the first reagent container 13a of each inspection item other than the inspection item B held in the first reagent rack 16a. The first reagent dispensing probe 23 discharges the aspirated first reagent into the reaction container 19. The first reagent dispensing probe 23 aspirates the first reagent in the first reagent container 13 a of the inspection item B placed in the first reagent storage chamber 17. The first reagent dispensing probe 23 discharges the aspirated first reagent into the reaction container 19.

  Further, in the dispensing of the second reagent, the second reagent dispensing probe 27 aspirates the second reagent in the second reagent container 13b of each inspection item other than the inspection item B held in the second reagent rack 16b. . The second reagent dispensing probe 27 discharges the aspirated second reagent into the reaction container 19 in which the first reagent paired with the second reagent is accommodated. Further, the second reagent dispensing probe 27 aspirates the second reagent in the second reagent container 13 b of the inspection item B placed in the second reagent storage chamber 18. The second reagent dispensing probe 27 discharges the aspirated second reagent into the reaction container 19 in which the first reagent of the inspection item B is accommodated.

  Thus, when there is no space for holding the first reagent container 13a in the first reagent rack 16a, the first reagent rack 13a is placed in the first reagent storage chamber 17 to be held in the first reagent rack 16a. The first reagent of the inspection item that could not be obtained can be aspirated and discharged. When there is no space for holding the second reagent container 13b in the second reagent rack 16b, the second reagent rack 13b can be held in the second reagent rack 16b by placing the second reagent container 13b in the second reagent storage chamber 18. The second reagent of the inspection item that could not be obtained can be aspirated and discharged.

  By executing the calculation function 61, the data processing circuit 60 generates standard data for each test item of one reagent system in which the first reagent container 13a is held in the first reagent rack 16a. The data processing circuit 60 generates standard data for each test item of the two reagent system in which the first reagent container 13a is held in the first reagent rack 16a and the second reagent container 13b is held in the second reagent rack 16b. The data processing circuit 60 generates calibration data for the test item B in which the first reagent container 13 a is placed in the first reagent storage chamber 17 and the second reagent container 13 b is placed in the second reagent storage chamber 18.

  The memory 62 stores calibration data for each inspection item generated by the data processing circuit 60. When the calibration data of all the inspection items generated by the data processing circuit 60 is printed and displayed from the output interface 70, the automatic analyzer 100 ends the calibration operation.

  Next, the first reagent container 13a of the test item B placed in the first reagent storage chamber 17 and the second reagent container 13b of the test item B placed in the second reagent storage chamber 18 are removed, and the first When an input for executing a test is performed from the input interface 80 in a state where the first reagent container 13a and the second reagent container 13b are not placed in the first reagent storage chamber 17 and the second reagent storage chamber 18, respectively, the analysis is performed. The control circuit 41 rotates each first reagent rack 16a and second reagent rack 16b. Then, the analysis control circuit 41 stores the reagent information written in all the first reagent containers 13a held in the first reagent rack 16a and all the second reagent containers 13b held in the second reagent rack 16b. The reagent information described is read by the reader 141 and the reader 151, respectively.

  Then, the analysis control circuit 41 determines the reagent information of the first reagent in all the first reagent containers 13a held in the first reagent rack 16a and the first reagent identified by the reagent information of the first reagent. Information on the holding position of the accommodated first reagent container 13a, reagent information on the second reagent in all the second reagent containers 13b held on the second reagent rack 16b, and reagent information on the second reagent The information of the holding position of the second reagent container 13b in which the second reagent identified in (2) is accommodated is acquired.

  Next, the analysis control circuit 41 cleans each reaction container 19, dispenses each test sample, and dispenses the first reagent for each test item in which the first reagent container 13a is held in the first reagent rack 16a. Agitation of the mixture of the first reagent for each test sample and each test item, dispensing of the second reagent for each test item in which the second reagent container 13b is held in the second reagent rack 16b, Test data is generated by agitating the test sample, the mixed solution of the first reagent and the second reagent of each test item, and measuring the stirred mixed solution for each cycle.

  During the test, the analysis control circuit 41 decreases the amount of the first reagent in the first reagent container 13a identified by the test item C1 among the first reagent containers 13a held in the first reagent rack 16a. When the amount corresponding to the number of warnings (warning amount) is reached, a warning message indicating that the first reagent of the test item C1 is insufficient is displayed on the monitor 72. For example, one replenishment container 13a for replenishment containing a sufficient amount of the first reagent is placed horizontally in the L1 direction from the intake port 17a with the side surface with the barcode facing the front side of the analysis mechanism 10. Is pushed into the first reagent storage chamber 17 at a predetermined position.

  As described above, since the first reagent storage chamber 17 is arranged at a position away from the first track T11, each first reagent container 13a in which the first reagent dispensing probe 23 is held in the first reagent rack 16a. The first reagent container 13a is stored in the first reagent container without contacting or colliding with the first reagent dispensing probe 23 or the first reagent dispensing arm 24 when the first reagent is dispensed into the reaction container 19. It can be placed in the chamber 17.

  For example, two first reagent containers 13a including the first reagent container 13a for replenishment are stored in the first reagent storage 14, and the two first reagent containers 13a held in the first reagent rack 16a are stored. A method of dispensing the first reagent in the other first reagent container 13a when the first reagent in one of the first reagent containers 13a decreases below the warning amount is also possible. However, since the first reagent containers 13a of many test items are held in the first reagent rack 16a, there is a limit to the number of first reagent containers 13a that can be further held. Therefore, when the first reagent in the first reagent container 13a held in the first reagent rack 16a reaches the warning amount, the first reagent on which the first reagent container 13a for replenishment can be placed according to the warning amount. By providing the storage chamber 17, it is possible to prevent the first reagent storage 14 from becoming large.

  The detector 171 detects the first reagent container 13a placed at a predetermined position. The reader 172 reads the reagent information written in the first reagent container 13a detected by the detector 171. When the reagent information read by the reader 172 is the inspection item C1, the analysis control circuit 41 further detects the first reagent of the inspection item C1 in the first reagent container 13a held in the first reagent rack 16a from the warning amount. The first reagent in the first reagent container 13a at the position where the reagent information has been read by the reader 172 when dispensing the first reagent of the inspection item C1 after reaching the limit amount that can be reduced and reduced. Dispense into the reaction vessel 19.

  In this way, when the first reagent in the first reagent container 13a held in the first reagent rack 16a is insufficient, the dispensing of the first reagent for each test item performed every cycle is temporarily stopped. Since it is not necessary to remove the reagent cover 142 and replace the first reagent container 13a in order to replenish the first reagent that is lacking, it is possible to prevent the throughput from being lowered and to perform a test quickly.

  Further, during the inspection, when the first reagent and the second reagent for each inspection item are dispensed for each cycle, the inspection item B removed from the first reagent storage chamber 17 after the calibration is completed. When the second reagent container 13b of the inspection item B removed from the first reagent container 13a and the second reagent storage chamber 18 is placed again in the first reagent storage chamber 17 and the second reagent storage chamber 18, respectively. The detector 171 and the detector 181 detect the first reagent container 13 a in the first reagent storage chamber 17 and the second reagent container 13 b in the second reagent storage chamber 18. Then, the reader 172 and the reader 182 respectively read the reagent information written in the detected first reagent container 13a and the reagent information written in the second reagent container 13b.

  When the reagent information read by the reader 172 and the reader 182 is information on the test item B, the analysis control circuit 41 performs the first test when dispensing the first reagent of the test item B set on the test sample. The first reagent in the first reagent container 13a of the inspection item B placed in the one reagent storage chamber 17 is dispensed into the reaction container 19 into which the sample has been dispensed. Further, when dispensing the second reagent of the inspection item B, the second reagent in the second reagent container 13b of the inspection item B placed in the second reagent storage chamber 18 is replaced with the first reagent of the inspection item B. Is dispensed into the reaction vessel 19 into which the liquid is dispensed. The measurement unit 31 generates test data by measuring a test sample in which the test item B is set and a mixed solution of the first and second reagents of the test item B. The data processing circuit 60 executes the calculation function 61 and uses the calibration data of the inspection item B stored in the memory 62 by calibration, and the analysis data of the inspection item B from the test data generated by the analysis mechanism 10. Is generated.

  In this way, the first reagent dispensing probe 23 does not descend to the position where the first reagent container 13a of the first reagent storage chamber 17 is not placed, and the first reagent container 13a is placed on the first reagent container 13a to be placed. However, since it does not descend until it is placed at a predetermined position, a collision between the first reagent dispensing probe 23 and the first reagent storage chamber 17 can be prevented. In addition, the first reagent container 13a is placed in the first reagent storage chamber 17 and the second reagent storage chamber 18 without stopping the dispensing of the first reagent and the second reagent for each inspection item performed every cycle. Therefore, the throughput can be prevented from being lowered and the inspection can be executed promptly.

  The data processing circuit 60 generates analysis data of each test sample for each inspection item based on the test data generated by the analysis mechanism 10. When all the analysis data generated by the data processing circuit 60 is printed and displayed from the output interface 70, the automatic analyzer 100 ends the inspection operation.

  According to the embodiment described above, the first upper stop position P1 above the first reagent container 13a at the suction position A1 held by the first reagent rack 16a and the second upper position above the reaction container 19 at the discharge position D1. The first reagent dispensing probe 23 that horizontally moves between the stop positions P2 along the first trajectory T11 is placed in the first reagent storage chamber 17 provided at a position away from the first trajectory T11. The first reagent is moved along the second trajectory T12 between the third upper stop position P3 and the second upper stop position P2 above the reagent container 13a and on the extension line of the first trajectory T11. When the first reagent in the first reagent container 13a held in the rack 16a is being dispensed, the first reagent is not contacted or collided with the first reagent dispensing probe 23 or the first reagent dispensing arm 24. Place the container 13a in the first reagent storage chamber 17 Can.

  Further, the third upper stop position P4 above the second reagent container 13b at the suction position A2 held by the second reagent rack 16b and the fifth upper stop position P5 above the discharge position D2 reaction container 19 are connected to the third upper stop position P5. The second reagent dispensing probe 27 moving along the trajectory T21 is above the second reagent container 13b placed in the second reagent storage chamber 18 provided at a position away from the third trajectory T21. The second reagent held by the second reagent rack 16b is moved between the sixth upper stop position P6 and the fifth upper stop position P5 on the extension line of the third track T21 along the fourth track T22. When the second reagent in the container 13b is being dispensed, the second reagent container 13b is not brought into contact with or collided with the second reagent dispensing probe 27 or the second reagent dispensing arm 28, and the second reagent storage chamber 18 is moved. It can be mounted on.

  Further, the intake port 17a of the first reagent storage chamber 17 is arranged on the outer peripheral side with respect to the second track T12, and is below the first reagent dispensing probe 23 that moves along the second track T12. The first reagent container 13a can be placed in the first reagent storage chamber 17 by placing and horizontally pushing in from the intake port 17a toward the second track T12. Thereby, the first reagent dispensing probe 23 and the first reagent dispensing arm 24 moving along the second trajectory T12, the first reagent container 13a placed in the first reagent storage chamber 17, and the first reagent container 13a. It is possible to prevent contact and collision with the hand of an operator who has one reagent container 13a.

  Further, the fourth trajectory is arranged from the intake port 18a disposed on the outer peripheral side of the fourth trajectory T22 and disposed below the second reagent dispensing probe 27 moving along the fourth trajectory T22. The second reagent container 13b can be placed in the second reagent storage chamber 18 by being pushed in horizontally in the direction of T22. As a result, the second reagent dispensing probe 27 and the second reagent dispensing arm 28 moving along the fourth trajectory T22, the second reagent container 13b placed in the second reagent storage chamber 18, and this Contact and collision with the hand of the worker holding the second reagent container 13b can be prevented.

  When the first reagent container 13a is placed at a predetermined position in the first reagent storage chamber 17, and the first reagent container 13a is additionally placed, the first reagent container 13a is removed from the inlet 17a through the first reagent container 13a. The first reagent dispensing probe 23 does not descend to the position of the additionally placed first reagent container 13a unless the reagent container 13a is horizontally pushed into a position where the reagent container 13a is not placed and placed at a predetermined position. Therefore, contact and collision between the first reagent container 13a and the first reagent dispensing probe 23 can be prevented.

  When the second reagent container 13b is placed at a predetermined position in the second reagent storage chamber 18, and the second reagent container 13b is additionally placed, the second reagent container 13b is removed from the inlet 18a through the second inlet 18a. The second reagent dispensing probe 27 does not descend to the position of the additionally mounted second reagent container 13b unless the reagent container 13b is horizontally pushed into a position where the reagent container 13b is not placed and placed at a predetermined position. Therefore, contact and collision between the second reagent container 13b and the second reagent dispensing probe 27 can be prevented.

  As described above, since the missing reagent can be replenished without once stopping the dispensing of the reagent, the inspection can be promptly executed.

  The term “processor” used in the above description is, for example, a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), an application specific integrated circuit (ASIC), a programmable logic device (for example, It means circuits such as a simple programmable logic device (SPLD), a complex programmable logic device (CPLD), and a field programmable gate array (FPGA). The processor implements a function by reading and executing a program stored in the storage circuit. Instead of storing the program in the storage circuit, the program may be directly incorporated in the processor circuit. In this case, the processor realizes the function by reading and executing the program incorporated in the circuit. Each processor of the above embodiment is not limited to being configured as a single circuit for each processor, but may be configured as a single processor by combining a plurality of independent circuits to realize its function. Good. Furthermore, a plurality of components in FIG. 1 may be integrated into one processor to realize the function.

  Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These novel embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the scope of the invention. These embodiments and modifications thereof are included in the scope and gist of the invention, and are included in the invention described in the claims and the equivalents thereof.

  13a ... 1st reagent container, 13b ... 2nd reagent container, 14 ... 1st reagent storage, 15 ... 2nd reagent storage, 16a ... 1st reagent rack, 16b ... 2nd reagent rack, 17 ... 1st reagent storage room, DESCRIPTION OF SYMBOLS 18 ... 2nd reagent storage chamber, 19 ... Reaction container, 23 ... 1st reagent dispensing probe, 24 ... 1st reagent dispensing arm, 27 ... 2nd reagent dispensing probe, 28 ... 2nd reagent dispensing arm.

Claims (13)

A reagent storage for storing the first reagent container;
A reagent storage unit provided apart from the reagent storage and capable of placing a second reagent container;
The reagent accommodated in the first reagent container is aspirated at a first position located on the reagent storage, and is accommodated in the second reagent container at a second position located on the reagent storage unit. A probe for aspirating a reagent and discharging the reagent aspirated from the first reagent container or the second reagent container to a reaction container at a third position;
An automatic analyzer comprising:   Moving the probe along a first trajectory between the first position and the third position, and a second trajectory between the second position and the third position; The automatic analyzer according to claim 1, further comprising an arm that supports movement along the axis.   The automatic analyzer according to claim 2, wherein the first trajectory and the second trajectory are circular arc trajectories located on the same circumference. The reagent storage unit has an intake port arranged below the probe, and takes in the second reagent container horizontally without contacting the probe through the intake port.
The automatic analyzer according to any one of claims 1 to 3. The reagent storage unit has a cover that covers the upper side of the second reagent container placed on the reagent storage unit,
5. The automatic analyzer according to claim 1, wherein the cover is provided with a through hole at a position corresponding to the position of 2.   A second reagent container containing a reagent having the same test item as the reagent in the first reagent container stored in the reagent container is placed in the reagent storage unit and stored in the reagent container. An analysis control circuit for causing the probe to suck a reagent from the second reagent container placed in the reagent storage unit when the reagent of the inspection item in the first reagent container reaches a predetermined amount or less. The automatic analyzer according to claim 1, further comprising: The reagent store stores a plurality of the first reagent containers,
The reagent storage unit has a reader that reads reagent information written in the second reagent container placed in the reagent storage unit by being pushed horizontally from the intake port,
When the second reagent container containing a reagent different from the reagents in all the first reagent containers stored in the reagent container is placed on the reagent storage unit, the probe is placed on the probe. The automatic analyzer according to claim 4, further comprising: an analysis control circuit that sucks the reagent in the reagent container. A reader for reading reagent information written in the second reagent container placed in the reagent storage unit;
The automatic analyzer according to any one of claims 1 to 5, further comprising an analysis control circuit that causes the probe to aspirate the reagent in the second reagent container after the reagent information is read by the reader. A measurement unit that generates test data by measuring a mixture of the test sample and the reagent;
When the second reagent container in which the predetermined reagent is stored is removed from the reagent storage unit and then the second reagent container is placed in the reagent storage unit again, the analysis control circuit The reader information on the reagent container of 2 is read by the reader,
9. The measurement unit according to claim 8, wherein when the reagent in the second reagent container whose reagent information has been read by the reader is the predetermined reagent, the measurement unit measures the test sample and a mixed solution of the reagent. Automatic analyzer.   The said reagent storage part can mount the said 2nd reagent container of a number smaller than the number of the said 1st reagent container which can be stored in the said reagent storage. Automatic analyzer. The reagent includes a first reagent housed in a third reagent container and a second reagent paired with the first reagent housed in a fourth reagent container,
Either one of the third reagent container or the fourth reagent container is placed in the reagent storage unit, the other reagent container is not stored in the reagent container, and the reagent 6. The automatic analyzer according to claim 1, further comprising an analysis control circuit that outputs an error message to an output interface when the error message is not placed in the storage unit. The reagent storage unit has a cover that covers the upper side of the second reagent container placed on the reagent storage unit,
The reagent storage unit is formed of a placement surface on which the second reagent container can be placed, a first side surface, a second side surface, a third side surface, and the cover. The automatic analyzer as described in any one.   The automatic analyzer according to claim 12, wherein the placement surface, the first side surface, the second side surface, and the third side surface are part of the automatic analyzer.