JP2017217195A - Multi-chamber container for freezing - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a freezing multi-chamber container capable of suppressing an information display part from getting wet when thawed.SOLUTION: A freezing multi-chamber container 1 is partitioned by partition walls 11, 12 into a gas storage chamber 20, a first liquid storage chamber 21 storing first liquid, and a second liquid storage chamber 22 storing second liquid. When these liquids and gas are to be mixed, the gas storage chamber 20, the first liquid storage chamber 21 and the second liquid storage chamber 22 can be communicated by opening the partition walls 11, 12. An information display part 35 is bonded on an area of the gas storage chamber 20 of the outer surface of the freezing multi-chamber container 1.SELECTED DRAWING: Figure 1

Description

  Embodiments of the present disclosure relate to a freezing multi-chamber container for freezing, for example, a cell-containing liquid and a drug.

  As a multi-chamber container, various unstable drugs that change over time when mixed are individually stored in each storage chamber, and when used, the partition between the storage chambers is opened by external force to allow the storage chambers to communicate with each other. Thus, a mixture of various drugs is known (see Patent Documents 1 and 2).

  Recently, in the fields of reproductive medicine, regenerative medicine, etc., when the above-mentioned multi-chamber container is used, and the cell-containing liquid and each drug are cryopreserved in a state of being individually stored in each storage chamber of the multi-chamber container and used There is an increasing need for thawing in a warm bath or the like (for example, at the time of transplantation) and mixing the cell-containing liquid and each drug by the above-described method.

Japanese Patent No. 4463205 Japanese Patent No. 51188838

  However, when the above-described multi-chamber container is used as a freezing multi-chamber container, the following problems occur. That is, since a label indicating information on the contents stored in each storage chamber is affixed to the outside of the multi-chamber container, it will get wet with dew condensation or hot bath liquid during thawing. As a result, it becomes difficult to read the information displayed on the label, and the label may be damaged or peeled off in some cases.

  Embodiments of the present disclosure have been made in view of the above points, and an object of the present disclosure is to provide a freezing multi-chamber container that can suppress wetting of an information display unit during thawing.

  A freezing multi-chamber container according to an embodiment of the present disclosure includes a plurality of storage chambers and a partition wall that partitions each storage chamber and is provided so as to allow communication between the partitioned storage chambers. The plurality of storage chambers include a liquid storage chamber in which liquid is stored and a gas storage chamber in which gas is stored. In the outer surface of the freezing multi-chamber container, An information display unit that displays information on at least the liquid stored in the liquid storage chamber is provided.

  In the multiple-chamber container for freezing according to an embodiment of the present disclosure, it is preferable that the liquid storage chamber is plural, and the gas storage chamber is disposed at an end portion of the multiple-chamber container for freezing. .

  In the multiple-chamber container for freezing according to an embodiment of the present disclosure, the volume of the gas storage chamber is equal to or greater than the volume of the liquid storage chamber having the largest volume among the plurality of liquid storage chambers, or the plurality of liquids. It is preferable that it is equal to or more than the total volume of the storage chamber.

  The freezing multi-chamber container according to one embodiment of the present disclosure further includes a discharge unit that discharges the liquid stored in the liquid storage chamber to the outside, and the discharge unit is provided in the gas storage chamber. It is preferable that

  In the freezing multi-chamber container according to an embodiment of the present disclosure, it is preferable that a weight portion is detachably provided on the liquid storage chamber side farthest from the gas storage chamber.

  According to the present disclosure, it is possible to prevent the occurrence of condensation at the time of thawing and the information display unit from being immersed in the warm bath liquid, and to suppress the wetness of the information display unit.

It is a front view which shows the multi-chamber container for freezing of 1st Embodiment. It is sectional drawing which follows the XX line of FIG. It is a front view which shows the multiple chamber container for freezing of 2nd Embodiment. It is a front view which shows the multi-chamber container for freezing of 3rd Embodiment. It is sectional drawing which follows the YY line | wire of FIG. It is a front view which shows the multiple chamber container for freezing of 4th Embodiment. It is a figure for demonstrating calculation of the maximum volume and an appropriate volume.

  Hereinafter, embodiments of a freezing multi-chamber container according to the present invention will be described with reference to the drawings. In the description of the drawings, the same elements are denoted by the same reference numerals, and redundant description is omitted.

<First Embodiment>
FIG. 1 is a front view showing a freezing multi-chamber container according to the first embodiment, and FIG. 2 is a sectional view taken along line XX of FIG. The freezing multi-chamber container 1 of the present embodiment is a so-called soft bag, in which two rectangular transparent resin sheets having the same size are stacked and heat-sealed (also referred to as heat welding) between the peripheral portions over four rounds. It is formed by doing. For this reason, the seal part 10 is formed over the four circumferences of the freezing multi-chamber container 1. The seal portion 10 extends in the vertical direction shown in FIG. 1 and includes a pair of relatively long long side seal portions 10a and a pair of relatively short short side seal portions 10b extending in the left-right direction. .

  Examples of the resin material used for the above-described resin sheet include high-density polyethylene (HDPE), polymethyl methacrylate (PMMA) having low adsorptivity and low elution for stored cell-containing liquids, liquids such as drugs, and the like. Polycarbonate (PC), polystyrene (PS), polyethylene terephthalate (PET), polypropylene (PP), polyethylene (PE), polyethylene naphthalate (PEN), cycloolefin polymer (COP), cycloolefin copolymer (COC), polyacrylonitrile (PAN).

  In the freezing multi-chamber container 1, two partition walls 11 and 12 are provided at predetermined intervals so as to cross the freezing multi-chamber container 1. These partition walls 11 and 12 are arranged in parallel to the short-side seal portion 10b, and connect the long-side seal portions 10a facing each other. Note that the partition wall 11 and the partition wall 12 are not necessarily arranged in parallel to the short side seal portion 10b, and the partition wall 11 and the partition wall 12 may not be parallel to each other. The internal space of the freezing multi-chamber container 1 is partitioned into three storage chambers by the partition walls 11 and 12, and in order from the upper side to the lower side, the gas storage chamber 20 for storing gas and the first liquid for storing the first liquid. A liquid storage chamber 21 and a second liquid storage chamber 22 for storing the second liquid are provided.

  That is, the gas storage chamber 20 is disposed at the upper end of the freezing multi-chamber container 1, and the second liquid storage chamber 22 is disposed at the lower end of the freezing multi-chamber container 1. The first liquid storage chamber 21 is disposed between the gas storage chamber 20 and the second liquid storage chamber 22. Here, the end means the region of the edge of the freezing multi-chamber container 1. The gas storage chamber 20 and the first liquid storage chamber 21 are separated from each other by the partition wall 11, and the first liquid storage chamber 21 and the second liquid storage chamber 22 are separated from each other by the partition wall 12. Has been.

  The partition walls 11 and 12 are formed by heat sealing similarly to the seal part 10, but the seal strength is weaker than that of the seal part 10. That is, the partition walls 11 and 12 are set to have a weak seal strength so that the partition walls 11 and 12 are easier to open than the seal portion 10. Therefore, for example, when the gas stored in the gas storage chamber 20 and the first liquid stored in the first liquid storage chamber 21 are desired to be mixed, the pressure is applied to the partition wall 11 from the gas storage chamber 20 side. To press the gas storage chamber 20. Since the partition wall 11 has a sealing strength weaker than that of the seal portion 10, the partition wall 11 peels first when a predetermined pressure is exceeded. Thereby, the partition wall 11 is opened, the gas storage chamber 20 and the first liquid storage chamber 21 communicate with each other, and the gas in the gas storage chamber 20 and the first liquid in the first liquid storage chamber 21 are mixed. It becomes possible. In this case, the first liquid storage chamber 21 may be pressed so as to apply pressure to the partition wall 11 from the first liquid storage chamber 21 side. Further, when the first liquid storage chamber 21 and the second liquid storage chamber 22 are desired to communicate with each other, the partition wall 12 may be opened by the above-described method. The strength of the seal is increased or decreased, for example, by adjusting the temperature, time, pressure, etc. during sealing.

  As the first liquid stored in the first liquid storage chamber 21 and the second liquid stored in the second liquid storage chamber 22, in addition to the cell-containing liquid, food-related liquids and pharmaceutical-related liquids are also conceivable. . Specifically, the food-related liquid includes beverages and seasonings. On the other hand, pharmaceutical liquids include electrolyte infusions such as physiological saline, sugar injections such as glucose, blood drugs, protein drugs such as antibiotics and antibodies, low molecular weight proteins, peptide drugs such as hormones, nucleic acids Pharmaceuticals, cell medicines, vaccines to prevent various infectious diseases, steroids, insulin, anticancer agents, proteolytic enzyme inhibitors, analgesics, antipyretic analgesics and anti-inflammatory agents, anesthetics, fat emulsions, blood pressure lowering agents, vasodilators And electrolyte correction injection solutions such as heparin sodium chloride and potassium lactate, vitamins, and contrast agents.

  In addition, the volume of the 1st liquid storage chamber 21 and the 2nd liquid storage chamber 22 may be made the same as needed, and may differ. On the other hand, the volume of the gas storage chamber 20 is equal to or greater than the volume of the liquid storage chamber having the largest volume among the first liquid storage chamber 21 and the second liquid storage chamber 22, or the first liquid storage chamber 21 and the second liquid. It is preferable to be equal to or greater than the total volume of the storage chamber 22. Here, “equivalent” means not only the case where they are equal, but also the case where they are slightly larger or slightly smaller. Further, when the gas, the first liquid and the second liquid in the freezing multi-chamber container 1 are mixed and discharged to the outside through the discharge port 33, 5% or more of the maximum volume of the freezing multi-chamber container 1 is gas. It is preferred that 10-20% of the maximum volume is gaseous.

The maximum volume and appropriate volume of the gas storage chamber 20, the first liquid storage chamber 21, and the second liquid storage chamber 22 can be obtained by the following well-known formula (see FIG. 7).
Maximum volume Vmax = (0.33 × S × a) − (0.11 × a ³ )
Proper volume V = a / 2 × a / 2 × (b−a / 2) ≈Vmax × 0.71
Or
Appropriate volume V = Vmax × 0.42
Here, a is the length of the short side and b is the length of the long side, but the lengths of both may be the same. S is the surface area (single side a × b) of each storage chamber.

  As shown in FIG. 1, the gas storage chamber 20 is provided with a filling port 30 for filling a gas therein. The filling port 30 is formed in a cylindrical shape from a resin material, and is attached to the long side seal portion 10a side. One end of the filling port 30 is inserted through the long side seal portion 10a and is sandwiched by the long side seal portion 10a. The other end protrudes outward, and its tip is sealed.

  Similarly, a filling port 31 for filling the first liquid is attached to the first liquid storage chamber 21, and a filling port 32 for filling the second liquid is attached to the second liquid storage chamber 22, respectively. . As shown in FIG. 1, the filling ports 30, 31, 32 are arranged so as to be aligned on the same side of the pair of long side seal portions 10 a. If it does in this way, it will become easy to perform filling work, when filling gas or liquid.

  Further, a discharge port (discharge portion) 33 is further attached to the uppermost end portion of the freezing multi-chamber container 1, that is, the short side seal portion 10b on the gas storage chamber 20 side. The discharge port 33 is a structure for connecting the gas storage chamber 20, the first liquid storage chamber 21, and the second liquid storage chamber 22 later, mixing the gas, the first liquid, and the second liquid and discharging them to the outside. . The discharge port 33 is formed in a cylindrical shape by a resin material like the filling ports 30, 31, 32, and one end portion of the discharge port 33 is inserted into the short side seal portion 10b and sandwiched by the short side seal portion 10b. The end protrudes outward and is closed by a sealing lid 34.

  Further, the region of the gas storage chamber 20 in the outer surface of the freezing multi-chamber container 1 relates to the first liquid stored in the first liquid storage chamber 21 and the second liquid stored in the second liquid storage chamber 22. An information display unit 35 for displaying information is provided. Examples of the information on the first liquid and the second liquid include the names, components, and notes on use.

  Moreover, as a form of the information display part 35, you may form by sticking the label on which the character etc. were printed to the gas storage chamber 20, or it is formed by printing information directly in the gas storage chamber 20. Also good. Furthermore, the information display unit 35 may be a label or an IC tag printed with a QR code (registered trademark) instead of characters. In the present embodiment, the information display unit 35 is formed by attaching a label on which information is printed to the region of the gas storage chamber 20 on the outer surface of the freezing multi-chamber container 1 with an adhesive.

  The area (size) of the information display unit 35 is not particularly limited as long as it does not exceed the area of the gas storage chamber 20 in the outer surface of the freezing multi-chamber container 1. For example, among the total surface area of the gas storage chamber 20, it may be affixed to only one side, or may be affixed to both sides. And if the area of the information display part 35 is enlarged, the amount of information displayed will also increase.

  The freezing multi-chamber container 1 configured as described above has a gas storage chamber 20 in which gas is stored, and an information display unit 35 is provided in the region of the gas storage chamber 20 in the outer surface of the freezing multi-chamber container 1. It is pasted. At the time of thawing, since the gas storage chamber 20 does not contain liquid compared to the first liquid storage chamber 21 and the second liquid storage chamber 22, the temperature easily changes, and the temperature tends to be the same as the outside air temperature. Water vapor in the outside air is less likely to condense on the outer wall of the storage chamber 20, and the risk that the information display unit 35 gets wet with condensation can be reduced. Further, since the gas storage chamber 20 is lifted by buoyancy during the warm bath, the information display unit 35 can be prevented from being immersed in the warm bath liquid, and the wetness of the information display unit 35 can be suppressed.

  In addition, the information display unit 35 is not attached to the first liquid storage chamber 21 and the second liquid storage chamber 22, and the freezing multi-chamber container 1 is formed of a transparent resin material. The first liquid stored in the liquid storage chamber 21 and the second liquid stored in the second liquid storage chamber 22 can be visually confirmed. For example, the presence or absence of discoloration of the liquid or mixing of foreign matters can be easily confirmed from the outside. can do. Furthermore, since the discharge port 33 and the sealing lid 34 are attached to the gas storage chamber 20, the risk of contamination due to immersion in the warm bath liquid can be reduced.

  When the freezing multi-chamber container 1 is frozen and thawed, the gas stored in the gas storage chamber 20 is stored in the first liquid storage chamber 21 and the second liquid storage chamber 22. Since there is no mixing with the second liquid, heat is easily transmitted and the efficiency of freezing and thawing can be increased. Furthermore, when the gas, the first liquid, and the second liquid are mixed and discharged to the outside, the gas exists in the freezing multi-chamber container 1, and therefore the inner surfaces of the freezing multi-chamber container 1 that are in contact with the gas are It is possible to prevent sticking and reduce the occurrence of liquid residue due to sticking between the inner surfaces.

  Note that when the gas, the first liquid, and the second liquid in the freezing multi-chamber container 1 are mixed, the gas storage chamber 20 and the first liquid storage chamber 21 are first communicated, and then the first liquid storage chamber. 21 and the second liquid storage chamber 22 may be communicated with each other, or vice versa. However, in the case where the first liquid and / or the second liquid is easily bubbled, the first liquid storage chamber 21 and the second liquid storage chamber 22 are communicated with each other in order to suppress the generation of bubbles due to contact with the gas. After that, it is preferable to make the gas storage chamber 20 and the first liquid storage chamber 21 communicate with each other.

Second Embodiment
FIG. 3 is a front view showing a freezing multi-chamber container according to the second embodiment. The difference between the freezing multi-chamber container 2 and the first embodiment is the shape of the container. Since other configurations are the same as those of the first embodiment, a duplicate description is omitted.

  Specifically, the multiple-chamber container 2 for freezing is formed by stacking two regular triangular transparent resin sheets having the same size and heat-sealing the peripheral portions over three sides. For this reason, the seal part 13 is formed over the three sides of the multiple-chamber container 1 for freezing. In the region surrounded by the seal portion 13, three partition walls 14, 15, and 16 extending from the equilateral triangle center of gravity to the midpoint position of each seal portion 13 are formed. Thus, the internal space of the freezing multi-chamber container 2 is equally divided into three storage chambers (the gas storage chamber 23, the first liquid storage chamber 24, and the second liquid storage chamber 25). The gas storage chamber 23 is arranged at one of the three ends of the freezing multi-chamber container 2. The partition walls 14, 15, and 16 are formed by heat sealing similarly to the seal portion 13, but the seal strength is weaker than that of the seal portion 13.

  A filling port 30 is attached to the gas storage chamber 23, a filling port 31 is attached to the first liquid storage chamber 24, and a filling port 32 is attached to the second liquid storage chamber 25. As shown in FIG. 3, a discharge port 33 is attached at a position corresponding to the apex of the equilateral triangle in the gas storage chamber 23, and the tip of the discharge port 33 is closed by a sealing lid 34. Furthermore, an information display unit 35 indicating information on the first liquid and the second liquid is attached to the region of the gas storage chamber 23 in the outer surface of the freezing multi-chamber container 2. The freezing multi-chamber container 2 configured as described above can obtain the same effects as those of the first embodiment.

<Third Embodiment>
FIG. 4 is a front view showing a freezing multi-chamber container according to the third embodiment, and FIG. 5 is a cross-sectional view taken along line YY of FIG. The difference between the freezing multi-chamber container 3 of the present embodiment and the first embodiment is that a weight portion 37 is further provided. Since other configurations are the same as those of the first embodiment, a duplicate description is omitted.

  Specifically, the second liquid storage chamber 22 side farthest from the gas storage chamber 20, that is, the short side seal portion 10 b on the second liquid storage chamber 22 side farthest from the gas storage chamber 20 includes a bag-like portion. 36 are connected. The bag-like portion 36 is formed, for example, by joining both end portions of the sheet member to the short side seal portion 10b while folding one sheet member. The bag-like portion 36 extends over the entire length of the short side seal portion 10 b, and a disc-like weight portion 37 is inserted into the bag-like portion 36.

  As shown in FIG. 4, since the left and right ends of the bag-like portion 36 are open, the weight portion 37 can be easily inserted into and removed from the bag-like portion 36. That is, the weight part 37 is detachably attached to the freezing multi-chamber container 3. The weight of the weight portion 37 is set such that, for example, the gas storage chamber 20 floats on the liquid surface in a state where the freezing multi-chamber container 3 is placed in the warm bath liquid (in other words, the gas storage chamber 20 is not submerged). Has been.

  The freezing multi-chamber container 3 of the present embodiment can obtain the same operational effects as those of the above-described first embodiment, and can further obtain the following operational effects. That is, the bag-shaped portion 36 is connected to the short side seal portion 10b on the second liquid storage chamber 22 side farthest from the gas storage chamber 20, and the weight portion 37 is inserted into the bag-shaped portion 36. When the freezing multi-chamber container 3 is thawed, the entire freezing multi-chamber container 3 can be erected. Accordingly, the contact area between the first liquid storage chamber 21 and the second liquid storage chamber 22 and the warm bath liquid is increased, so that the heat exchange rate can be increased and the thawing efficiency can be improved.

  Moreover, the risk that the information display part 35 affixed to the area | region of the gas storage chamber 20 among the outer surfaces of the freezing multi-chamber container 3 will get wet with warm bath liquid by making the freezing multi-chamber container 3 whole stand up, the discharge port 33 In addition, the risk of the sealing lid 34 being contaminated with the warm bath liquid can be further reduced. Furthermore, since the weight part 37 is detachably attached to the freezing multi-chamber container 3, the weight part 37 can be easily attached or detached as necessary.

<Fourth embodiment>
FIG. 6 is a front view showing a freezing multi-chamber container according to the fourth embodiment. The difference between the freezing multi-chamber container 4 of the present embodiment and the third embodiment is the attachment form of the weight portion 38. Since other configurations are the same as those of the third embodiment, a duplicate description is omitted.

  Specifically, the weight portion 38 is formed in a block shape and is integrally connected to the fastener 39 with a string or the like. A plurality of weight portions 38 are prepared, and the number attached to the freezing multi-chamber container 1 can be freely adjusted according to the weight, shape, etc. of the freezing multi-chamber container 1. When attaching the weight portion 38 to the freezing multi-chamber container 1, the second liquid storage chamber 22 located farthest from the gas storage chamber 20, that is, the second liquid storage chamber 22 side farthest from the gas storage chamber 20. This is performed by sandwiching the short side seal portion 10b on the side between the fasteners 39. The freezing multi-chamber container 4 of the present embodiment can obtain the same effects as those of the third embodiment.

  Although the embodiments of the present invention have been described in detail above, the present invention is not limited to the above-described embodiments, and various designs can be made without departing from the spirit of the present invention described in the claims. It can be changed. For example, the partition wall may be formed by using a closure, a magnet, or the like in addition to the above-described heat seal. Further, the number of the liquid storage chambers is not limited to the above-described content, and can be appropriately increased or decreased as necessary. Further, the shape of the freezing multi-chamber container may be other polygons or circles in addition to the above-described contents.

  Moreover, the weight part 37 of 3rd Embodiment or the weight part 38 of 4th Embodiment is applied also to the multiple-chamber container 2 for freezing of 2nd Embodiment. For example, the first liquid storage chamber 24 and the seal portion 13 on the second liquid storage chamber 25 side farthest from the gas storage chamber 23 so that the entire freezing multi-chamber container 2 is upright while the gas storage chamber 23 is positioned upward. The weights 37 and 38 may be attached to or removed from the body.

1, 2, 3, 4 Multi-chamber container for freezing 10, 13 Sealing portion 11, 12, 14, 15, 16 Partition 20, 23 Gas storage chamber 21, 24 First liquid storage chamber 22, 25 Second liquid storage chamber 30 , 31, 32 Filling port 33 Discharge port (discharge part)
34 Sealing lid 35 Information display part 36 Bag-like part 37,38 Weight part 39 Fastening

Claims (5)

In a freezing multi-chamber container comprising a plurality of storage chambers, and a partition wall that partitions each storage chamber and is provided so as to allow communication between the partitioned storage chambers.
The plurality of storage chambers include a liquid storage chamber for storing liquid and a gas storage chamber for storing gas,
An information display unit for displaying at least information on the liquid stored in the liquid storage chamber is provided in the region of the gas storage chamber in the outer surface of the freezing multi-chamber container. Chamber container. The liquid storage chamber is plural,
The multi-chamber container for freezing according to claim 1, wherein the gas storage chamber is disposed at an end portion of the multi-chamber container for freezing.   The volume of the gas storage chamber is equal to or greater than the volume of the liquid storage chamber having the largest volume among the plurality of liquid storage chambers, or equal to or greater than the total volume of the plurality of liquid storage chambers. The freezing multi-chamber container according to claim 2. A discharge unit for discharging the liquid stored in the liquid storage chamber to the outside;
The said discharge part is provided in the said gas storage chamber, The multi-chamber container for freezing as described in any one of Claims 1-3 characterized by the above-mentioned.   The multi-chamber container for freezing according to any one of claims 1 to 4, wherein a weight portion is detachably provided on the liquid storage chamber side farthest from the gas storage chamber.

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