JP2017205080A - Isolator system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an isolator system that reduces an aeration time therein without providing a dedicated pump or blower in an incubator.SOLUTION: According to the present invention, there is provide an isolator system in which an incubator 14 is connected to the isolator 12. Here, the isolator 12 and the incubator 14 can be connected/shut off by the open/close doors 42, 44. Here, the system is provided with a decontamination gas generator 18 for supplying decontamination gas to the isolator 12 and an air supply device 20 capable of respectively supplying/interrupting air to the isolator 12 and the incubator 14. During aeration work, the isolator 12, the incubator 14, and an air exhaust device 22 provided in the isolator 12 while supplying air to the connecting portion 16 are driven. When the decontamination gas concentration in the isolator 12 decreases, the on-off valves 30 V and 34 V are closed to cut off the supply of air to the isolator 12 and the connection portion 16 to allow air to be supplied only to the incubator 14.SELECTED DRAWING: Figure 1

Description

  The present invention relates to an isolator system including an incubator.

  A method is known in which an incubator is connected to an isolator and the incubator is decontaminated along with the decontamination of the isolator. In such a method, the decontamination gas is supplied into the isolator and the incubator in a state where the isolator and the incubator are in communication, and after the same state is maintained for a predetermined time, the replacement air is supplied to discharge the decontamination gas. Perform aeration. The opening of the incubator is designed to be as small as possible to avoid temperature changes, and in aeration, the atmosphere in the incubator is exhausted through this small opening. Therefore, the efficiency of discharging the decontamination gas is poor, and a lot of time is required for aeration. In order to increase the efficiency of exhausting the decontamination gas, the pump is installed by installing a pump that introduces outside air into the incubator (Patent Document 1) or by operating a blower arranged to forcibly circulate the culture gas in the incubator. A configuration (Patent Document 2) that increases the discharge efficiency of dye gas has also been proposed.

JP-A-2015-97480 Japanese Patent No. 4799221

  However, in the configurations of Patent Documents 1 and 2, although the efficiency is somewhat improved, the incubator is provided with a dedicated pump and a blower, which increases the size and cost of the incubator.

  An object of the present invention is to shorten the aeration time without providing a dedicated pump or blower in the incubator.

  The isolator system of the present invention includes an isolator, an incubator connected to the isolator, an open / close door that communicates / blocks between the isolator and the incubator, and an air that is connected to the isolator and can supply / block air. The supply means, the exhaust means provided in the isolator, the decontamination gas generation means for generating a decontamination gas, and the isolator and the incubator can be communicated with / disconnected from the decontamination gas generation means. A circulation passage having a supply pipe, a return pipe communicating the isolator and the decontamination gas generation means, a circulation pump disposed in the circulation path, the air supply means, the decontamination gas generation means, and the And a control means for controlling communication / shutoff of the circulation pump and the supply pipe. When supplying the decontamination gas to the inside of the solator and the incubator, the decontamination gas generated from the decontamination gas generating means is supplied to the isolator and the incubator with the opening / closing door opened to supply the circulation passage When performing aeration to decontaminate the inside of the isolator and the incubator and evacuate the decontamination gas while circulating through the air, air is supplied to the isolator by the air supply means in a state where the door is opened. However, from the first operating state of supplying the air circulated to the isolator and the incubator via the supply pipe of the circulation passage, the communication between the supply pipe and the isolator is interrupted to circulate to the isolator. The supplied air is stopped and the incubator is circulated. It is characterized in that switching to the second operating state to continue the supply of been air.

  A detector for detecting the concentration of the decontamination gas may be provided in the isolator, and switching from the first operating state to the second operating state may be performed based on the signal of the detector.

  It is good also as a structure which switches to a said 2nd operation state after predetermined time progress from a said 1st operation state.

  The opening / closing door may be switchable between a large open state and a small open state.

  The air supply means and the incubator may be connected via an open / close valve, and air may be supplied from the air supply means to the incubator during the first operation state and the second operation state.

  According to the present invention, the isolator system can shorten the aeration time without providing a dedicated pump or blower in the incubator.

It is a figure which shows the structure of the fluid circuit which performs decontamination and aeration of the isolator system which is one Embodiment of this invention (at the time of isolator driving | operation). It is a block diagram which shows the electric constitution of the isolator system of this embodiment. It is a sectional side view of a connection part in the state where the 1st door and the 2nd door were closed. It is a sectional side view of a connection part showing the state where the 1st door and the 2nd door were opened. It is a fluid circuit diagram showing the state of the isolator system of a 1st embodiment at the time of decontamination work. It is a fluid circuit diagram which shows the state of the isolator system of 1st Embodiment at the time of aeration operation | work (1st operation state). It is a fluid circuit diagram which shows another example of the method of aeration in the isolator system of 1st Embodiment (2nd operation state). It is a figure which shows the structure of the fluid circuit which performs decontamination and aeration of the isolator system of 2nd Embodiment of this invention (at the time of decontamination work). It is a figure which shows the structure of the fluid circuit at the time of the aeration operation | work of the isolator system of 2nd Embodiment (1st operation state). It is a figure which shows the structure of the fluid circuit at the time of another aeration operation | work of the isolator system of 2nd Embodiment (2nd operation state). It is a sectional side view of the modification of a 2nd door.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a diagram showing a configuration of a fluid circuit that performs decontamination and aeration of an isolator system according to a first embodiment of the present invention. In addition, in FIG. 1, the state of each valve | bulb and each door at the time of isolator operation | movement is shown so that it may mention later.

  The isolator system 10 of this embodiment includes an isolator 12 and an incubator 14, and the incubator 14 is coupled to the isolator 12 via a connection portion 16. In addition, the isolator system 10 supplies air into the isolator 12, the incubator 14, the decontamination gas generator (decontamination gas generation means) 18 that generates the decontamination gas supplied into the connection portion 16, and the isolator 12. An air supply device (air supply means) 20 and an air exhaust device (exhaust means) 22 for exhausting air from the isolator 12 are provided.

  The decontamination gas generator 18 includes a pump 26 for supplying the hydrogen peroxide solution sealed in the container V to the gas generator 28. The gas generator 28 heats and vaporizes the hydrogen peroxide solution supplied using, for example, a heater (not shown). The hydrogen peroxide solution vaporized by the gas generator 28 can be supplied as a decontamination gas to the air supply chamber 32 provided in the isolator 12 via the main supply pipe 19 and the first supply pipe 30, and the main supply. It can be supplied to the connecting portion 16 and the incubator 14 through the pipe 19, the second and third supply pipes 34 and 52, respectively. The first supply pipe 30 is provided with an opening / closing valve 30V, and the supply of the decontamination gas to the air supply chamber 32 is controlled by the opening / closing valve 30V. The second supply pipe 34 is provided with an opening / closing valve 34V and a filter 34F, and the supply of the decontamination gas to the connection portion 16 is controlled by the opening / closing valve 34V. Similarly, the third supply pipe 52 is provided with an open / close valve 52V and a filter 52F, and the supply of the decontamination gas to the incubator 14 is controlled by the open / close valve 52V. The decontamination gas that has flowed through the open / close valves 34V and 52V is supplied to the connecting portion 16 and the incubator 14 via the filters 34F and 52F, respectively. The third supply pipe 52 is detachably attached to the incubator 14, is attached when the incubator 14 is coupled to the connection portion 16, and is removed when the incubator 14 is detached from the connection portion 16.

  In addition to the first supply pipe 30, the air supply device 20 is connected to the supply chamber 32. The air supply device 20 includes a catalyst 20C, an air supply blower 20B, and an open / close valve 20V from the upstream side, and opens and closes the open / close valve 20V to operate the supply air blower 20B, thereby sucking outside air through the catalyst 20C, and the open / close valve. It can be supplied to the air supply chamber 32 via 20V. The air supply chamber 32 communicates with the isolator 12 via the filter 32F, and the decontamination gas supplied from the first supply pipe 30 or the air supplied from the air supply device 20 passes through the filter 32F. Supplied in.

  The isolator 12 is provided with an exhaust chamber 36, and the isolator 12 and the exhaust chamber 36 are communicated with each other via a filter 36F. An air exhaust device 22 is connected to the exhaust chamber 36, and a return pipe 38 communicating with the main supply pipe 19 is connected via a gas generator 28. The air exhaust device 22 includes an opening / closing valve 22V, a catalyst 22C, and an exhaust blower 22B from the upstream side, and exhausts from the isolator 12 via the catalyst 22C by opening the opening / closing valve 22V and operating the exhaust blower 22B. The return pipe 38 is a pipe for recirculating the decontamination gas in the isolator 12 to the gas generator 28. The decontamination gas flowing from the isolator 12 to the exhaust chamber 36 through the filter 36F is supplied to the open / close valve 38V. And is returned to the gas generator 28 by the circulation blower 38B. That is, a circulation path is formed by the main supply pipe 19, the first to third supply pipes 30, 34, 52 and the return pipe 38.

  The isolator 12 is provided with a first door (opening / closing door) 42 for communicating the isolator 12 with the connection portion 16, and the incubator 14 is provided with a second door (opening / closing door) 44 smaller than the first door 42. It is done. The first door 42 and the second door 44 are provided with rotary actuators 42R and 44R, respectively, and each door can be opened and closed automatically. The incubator 14 is installed on a cart (not shown) with a caster, and is connected to the isolator 12 so that the second door 44 faces the first door 42. In a state where the incubator 14 is connected to the isolator, the first door 42 and the second door 44 are surrounded by a wall surface, thereby forming the connection portion 16 isolated from the external atmosphere.

  The isolator 12 and the incubator 14 are provided with concentration detectors 12G and 14G for detecting the concentration of the decontamination gas, and the respective detection signals are transmitted from the control device (control means) as shown in the block diagram of FIG. ) 40. The control device 40 also controls the opening / closing of the opening / closing valves 20V, 22V, 30V, 34V, 38V, 52V, and the operation of the supply blower 20B, the exhaust blower 22B, the circulation blower 38B, the pump 26, and the gas generator 28.

  3 and 4 are side cross-sectional views showing configurations of the connection portion 16 and the first door 42 of the isolator 12 and the second door 44 of the incubator 14.

  FIG. 3 shows a state in which the first door 42 and the second door 44 are closed. The state shown in FIG. 3 is applied until the incubator 14 is connected to the isolator 12 and the connection portion 16 is decontaminated, or when the incubator 14 is disconnected from the isolator 12. 4 shows a state in which the first door 42 and the second door 44 are opened. The state of FIG. 4 is when the article is moved between the isolator 12 and the incubator 14 while the isolator 12 is in operation. Alternatively, it is applied to the decontamination and aeration of the isolator system 10.

  As shown in FIGS. 3 and 4, the first door 42 is attached to the inside of the side wall surface of the isolator 12 with the upper side as an axis, and is flipped up and held inside the isolator 12 in the open position. A seal 12S is provided around the first opening 12H provided on the wall surface of the isolator 12 closed by the first door 42 so as to surround the edge of the first opening 12H. In the closed position where the first door 42 is closed, the first door 42 is pressed against the seal 12S, and the first door 42 hermetically closes the first opening 12H.

  On the other hand, the second door 44 is attached to the outside of the side wall surface of the incubator 14 with the upper side as an axis, and is flipped up and held outside the incubator 14 in the open position (see FIG. 4). A seal 14 </ b> S is provided on the outer wall surface along the edge of the second opening 14 </ b> H around the second opening 14 </ b> H provided on the wall surface of the incubator 14 and closed by the second door 44. In the closed position where the second door 44 is closed, the second door 44 is pressed against the seal 14S, and the second door 44 can airtightly close the periphery of the second opening 14H.

  The incubator 14 is connected to the isolator 12 from the side wall of the incubator 14 by surrounding the second opening 14H and extending outward, and from the side wall of the isolator 12 by surrounding the first opening 12H and extending outward. This is done by fitting the connecting cylinder 48. The connecting cylinder 48 is fitted inside the bracket 46, for example, and is fixed to the bracket 46 using a predetermined fastening member 48F.

  Further, the isolator 12 of the present embodiment further includes an inner cylinder 50 that surrounds the first opening 12H inside the connecting cylinder 48 and extends outward from the side wall of the isolator 12. A seal 50S is provided at the tip of the inner cylinder 50 along the entire circumference of the opening. When the incubator 14 is connected, the seal 50S is pressed against the side wall around the second opening 14H of the incubator 14. Thereby, the isolator 12 and the incubator 14 are communicated with each other through the first openings 12H and 14H, and the connection portion 16 isolated from the external atmosphere is formed.

  Next, referring to FIGS. 1, 5, and 6, when the isolator system 10 according to the first embodiment is in operation, decontamination work, and aeration work, that is, each valve 20V, 22V, 30V, 34V, The opening / closing states of 38V and 52V, the blower 20B, 22B, 38B, the driving state of the pump 26, and the opening / closing states of the first door 42 and the second door 44 will be described. 1, 5, and 6, the open / closed state of each valve and each door indicates that the white is open and black is closed. Regarding the blowers 20B, 22B, and 38B and the pump 26, white indicates an operating state and black indicates a stopped state.

  As described above, FIG. 1 shows an operating state in which the isolator 12 is used. During the operation of the isolator, the operation of the decontamination gas generator 18 used for decontamination and aeration is stopped. That is, the opening / closing valves 30V, 34V, 38V, and 52V are closed, and the operation of the pump 26 and the circulation blower 38B is stopped. On the other hand, the air supply device 20 and the air exhaust device 22 are operated, the open / close valves 20V and 22V are opened, and the supply blower 20B and the exhaust blower 22B are operated. That is, air is supplied to the isolator 12 through the catalyst 20C and the filter 32F, and the air in the isolator 12 is discharged to the outside through the filter 36F and the catalyst 22C. At this time, the pressure in the isolator 12 is kept at a positive pressure with respect to the outside air.

  In operation of the isolator 12 to which the incubator 14 is connected, the first door 42 of the isolator 12 is opened. On the other hand, the second door 44 of the incubator 14 connected to the isolator 12 is opened and closed by driving, for example, a rotary actuator 44R (see FIGS. 3 and 4). That is, when an operator puts and removes articles such as culture between the isolator 12 and the incubator 14, the second door 44 is opened and articles are put in and out through the second opening 14 </ b> H.

  FIG. 5 shows the operating state of the isolator system 10 during the decontamination work. At the time of decontamination work, the operation of the air supply device 20 and the air exhaust device 22 is stopped, and the decontamination gas generator 18 is operated. That is, the on-off valves 20V and 22V are closed, the operation of the air supply blower 20B and the exhaust blower 22B is stopped, the on-off valves 30V, 34V, 38V and 52V are opened, and the pump 26 and the circulation blower 38B are operated. .

  At this time, the first door 42 of the isolator 12 is opened, and the second door 44 of the incubator 14 connected to the isolator 12 is also opened, so that the isolator 12 and the incubator 14 have the first and second openings. The parts 12H and 14H communicate with each other.

  That is, the hydrogen peroxide solution supplied from the container V by the pump 26 is vaporized by the gas generator 28, sent to the air supply chamber 32 through the first supply pipe 30 by the circulation blower 38B, and passed through the filter 32F. It is fed into the isolator 12. Further, the decontamination gas is sent to the connection unit 16 and the incubator 14 through the filters 34F and 52F of the second and third supply pipes 34 and 52. The decontamination gas sent to the isolator 12, the connection portion 16, and the incubator 14 is returned to the gas generator 28 through the return pipe 38 by the circulation blower 38B.

  FIG. 6 shows an operating state (first operating state) of the isolator system 10 during aeration work. The aeration is performed to discharge the decontamination gas from the isolator 12 and the incubator 14 after the decontamination work is completed. In the aeration work of this embodiment, in addition to the operation of the air supply device 20 and the air exhaust device 22, the circulation pump 38B is operated. That is, the opening / closing valves 20V, 22V are opened, the supply blower 20B and the exhaust blower 22B are operated, and the opening / closing valves 30V, 34V, 38V, 52V are opened, and the circulation blower 38B is operated. However, the heaters of the pump 26 and the gas generator 28 are stopped.

  At this time, as in the decontamination operation, the first door 42 of the isolator 12 is opened, and the second door 44 of the incubator 14 connected to the isolator 12 is also opened as shown in FIG. The That is, the isolator 12 and the incubator 14 are communicated with each other through the first and second openings 12H and 14H.

  By operating the air supply device 20 and the air exhaust device 22, air is supplied to the isolator 12 through the catalyst 20C and the filter 32F. On the other hand, a part of the atmosphere in the isolator 12 is discharged to the outside through the filter 36F and the catalyst 22C, and a part is circulated through the return pipe 38 by the circulation blower 38B. The air recirculated through the return pipe 38 is sent into the isolator 12, the connection portion 16, and the incubator 14 through the first, second, and third supply pipes 30, 34, and 52, respectively. Or is further circulated through the return line 38.

  Note that the amount of air supplied to the isolator 12, the connection portion 16, and the incubator 14 in the aeration operation is proportional to the volume of each part, for example. Therefore, the first to third supply pipes 30, 34, 52 may be provided with a throttle so that the supply amount corresponds to this ratio.

  Since air is exhausted directly from the isolator 12 by the air exhaust device 22, aeration is completed earlier than the incubator. Therefore, in this embodiment, when the decontamination gas concentration detected by the concentration detector 12G of the isolator 12 becomes a predetermined value or less, as shown in FIG. 7, the opening / closing valves 30V of the first and second supply pipes 30, 34 are used. , 34V is closed, the supply of air to the isolator 12 and the connecting portion 16 is stopped, and all the supply of air is concentrated in the incubator 14 (second operating state). Further, when the decontamination gas concentration detected by the concentration detector 14G of the incubator 14 becomes a predetermined value or less, the operation of the circulation blower 38B is stopped and the aeration operation is ended.

  At this time, the opening / closing switching control of the opening / closing valves 30V, 34V and the on / off control of the operation of the supply blower 20B, the exhaust blower 22B, and the circulation blower 38B are based on the signals from the concentration detectors 12G, 14G. 2).

  As described above, according to the first embodiment, the third decontamination gas pipe is connected to the incubator so that aeration air (gas) can be directly supplied to the incubator, so that a dedicated pump or blower is provided in the incubator. Aeration time can be shortened without providing.

  Further, in the first embodiment, when the decontamination gas concentration of the isolator becomes a predetermined value or less, all the air supply is concentrated in the incubator, so that the flow rate of air supplied to the incubator is increased and the removal in the incubator is performed. Promotes dye gas emissions.

  Next, an isolator system according to a second embodiment of the present invention will be described with reference to FIGS. 8 to 10 are fluid circuit diagrams showing the state of each valve and each door at the time of decontamination work and aeration in the isolator system of the second embodiment.

  In the isolator system 60 of the second embodiment, the downstream side of the opening / closing valve 20V of the air supply device 20 in the first embodiment is bypassed to the downstream side of the opening / closing valves 34V, 52 of the second and third supply pipes 34, 52. The bypass passage 54 is provided, and the open / close valves 21V, 35V, and 53V are provided between the connecting portion of the bypass passage 54 and the air supply chamber 32, the filter 34F, and the filter 52F. Other configurations are the same as those of the isolator system 10 of the first embodiment. In the following description, the same reference numerals are used for the same configurations as those of the first embodiment, and the description thereof is omitted.

  Also during the decontamination work of the second embodiment, the operation of the air supply device 20 and the air exhaust device 22 is stopped and the decontamination gas generator 18 is operated as in the first embodiment. That is, the on-off valves 20V, 21V, and 22V are closed, the operation of the supply blower 20B and the exhaust blower 22B is stopped, and the on-off valves 30V, 34V, 35V, 38V, 52V, and 53V are opened, and the pump 26 and the circulation The blower 38B is operated.

  At this time, the first door 42 of the isolator 12 is opened, and the second door 44 of the incubator 14 connected to the isolator 12 is also opened, so that the isolator 12 and the incubator 14 have the first and second openings. The parts 12H and 14H communicate with each other.

  That is, the hydrogen peroxide solution supplied from the container V by the pump 26 is vaporized by the gas generator 28, sent to the air supply chamber 32 through the first supply pipe 30 by the circulation blower 38B, and passed through the filter 32F. It is fed into the isolator 12. Further, the decontamination gas is sent to the connection unit 16 and the incubator 14 through the filters 34F and 52F of the second and third supply pipes 34 and 52. The decontamination gas sent to the isolator 12, the connection portion 16, and the incubator 14 is returned to the gas generator 28 through the return pipe 38 by the circulation blower 38B.

  FIG. 9 shows an operating state (first operating state) of the isolator system 60 during aeration work. In the aeration operation of the present embodiment, the circulation pump 38B is operated in addition to the operation of the air supply device 20 and the air exhaust device 22 as in the first embodiment. That is, the open / close valves 20V, 21V, and 22V are opened, the supply blower 20B and the exhaust blower 22B are operated, and the open / close valves 30V, 34V, 35V, 38V, 52V, and 53V are opened, and the circulation blower 38B is operated. The However, the heaters of the pump 26 and the gas generator 28 are stopped.

  At this time, as in the first embodiment, the first door 42 of the isolator 12 is opened, and the second door 44 of the incubator 14 connected to the isolator 12 is also opened as shown in FIG. The That is, the isolator 12 and the incubator 14 are communicated with each other through the first and second openings 12H and 14H.

  By operating the air supply device 20 and the air exhaust device 22, air is supplied to the isolator 12 through the catalyst 20C and the filter 32F. On the other hand, a part of the atmosphere in the isolator 12 is discharged to the outside through the filter 36F and the catalyst 22C, and a part is circulated through the return pipe 38 by the circulation blower 38B. The air recirculated through the return pipe 38 is sent into the isolator 12, the connection portion 16, and the incubator 14 through the first, second, and third supply pipes 30, 34, and 52, respectively. Or is further circulated through the return line 38.

  As in the case of the first embodiment, since the air is exhausted directly from the isolator 12 by the air exhaust device 22, aeration is completed earlier than the incubator. Therefore, also in the second embodiment, when the decontamination gas concentration detected by the concentration detector 12G of the isolator 12 becomes a predetermined value or less, the first and second supply pipes 30 and 34 are opened and closed as shown in FIG. Close valves 30V and 34V. On the other hand, in the isolator system 60 of the second embodiment, the open / close valves 35V and 53V are kept open (second operating state).

  At this time, a part of the air sucked from the air supply device 20 is sent to the second and third supply pipes 34 and 52 through the bypass passage 54 and supplied to the incubator 14 and the connection portion 16, respectively. . That is, the air circulated by the blower 38B and the air supplied from the air supply device 20 by the blower 20B are supplied to the third supply pipe 32, while the air is supplied to the connection portion 16 and the isolator 12 by the blower 20B. Only the air supplied from the supply device 20 is distributed and supplied. Therefore, more air can be concentrated and supplied to the incubator 14 with respect to the isolator 12 and the connection part 16, and the work efficiency of aeration is improved. Similarly to the first embodiment, when the decontamination gas concentration detected by the concentration detector 14G of the incubator 14 becomes a predetermined value or less, the operation of the circulation blower 38B is stopped and the aeration operation is ended.

  As described above, the isolator system according to the second embodiment can obtain substantially the same effect as that of the first embodiment.

  FIG. 11 is a side sectional view of a modified example of the second door provided in the incubator of the first and second embodiments.

  The modified second door 53 is provided in the incubator 14, and the third opening 14H ′ having an outer dimension slightly smaller than the first opening 12H of the isolator 12 is provided around the third opening 14H ′. This is a flip-up type door that opens outwardly and cooperates with the seal 14S ′. The second door 53 further includes a small door 45 that opens outwardly from a substantially lower center. The small door 45 is, for example, a flip-up door that opens outwardly and closes the opening 53H provided in the second door 53 in an airtight manner in cooperation with a seal 53S provided around the opening 53H.

  In the modified example, the small door 45 plays the role of the second door 44 of the first and second embodiments, and the second door 54 is closed during operation of the isolator, so that the article can be taken in and out of the incubator 14. 45 is opened and performed through the opening 53H (small open state). The second door 53 is opened during the decontamination work and the aeration work, and the isolator 12 and the incubator 14 are communicated with each other through the third opening 14H ′ wider than the opening 53H, so that the aeration work is performed (a large open state). That is, when the second door of the modified example is used, the isolator 12 and the incubator 14 are communicated with each other through a wider opening, and decontamination / aeration can be performed more effectively.

  In addition, although the 1st, 2nd door and small door of this embodiment are a flip-up type, a hinged door type may be sufficient. Further, the second door may have a shutter-like configuration, and in that case, the small opening state and the large opening state may be switched by adjusting the opening amount of the shutter.

  In this embodiment, concentration detectors are provided in the isolator and incubator, and valves and blowers are controlled based on these values.However, a timer is provided in place of the concentration detector to control opening and closing of each valve according to time. Operation control of each blower may be performed.

DESCRIPTION OF SYMBOLS 10, 60 Isolator system 12 Isolator 12G, 14G Concentration detector 12H 1st opening part 14 Incubator 14H 2nd opening part 14H '3rd opening part 16 Connection part 18 Decontamination gas generator 20 Air supply apparatus 20V, 22V, 30V , 34V, 38V, 52V Open / close valve 21V, 35V, 53V Open / close valve 22 Air exhaust device 30 First supply pipe 34 Second supply pipe 40 Controller 42 First door 44 Second door 52 Third supply pipe

Claims (5)

An isolator,
An incubator connected to the isolator;
An open / close door for communicating / blocking between the isolator and the incubator;
An air supply means connected to the isolator and capable of supplying / blocking air;
Exhaust means provided in the isolator;
Decontamination gas generating means for generating decontamination gas;
A circulation passage having a supply pipe capable of communicating / blocking communicating with each of the isolator and the incubator and the decontamination gas generating means; and a return pipe communicating the isolator and the decontamination gas generating means;
A circulation pump disposed in the circulation passage;
A control means for controlling communication / blocking of the air supply means, the decontamination gas generation means, the circulation pump, and the supply pipe;
The control means includes
When supplying the decontamination gas to the inside of the isolator and the incubator, the decontamination gas generated from the decontamination gas generating means is supplied to the isolator and the incubator with the opening / closing door opened. While circulating through the passage, decontaminate the inside of the isolator and the incubator,
When aeration for discharging decontamination gas is performed, air is supplied to the isolator by the air supply means while the open / close door is opened, and the isolator and the incubator are supplied to the isolator through a supply pipe of the circulation passage. By shutting off the communication between the supply pipe and the isolator from the first operating state for supplying the circulated air, the supply of the circulated air to the isolator is stopped and the circulation is performed to the incubator. An isolator system that switches to a second operating state in which air supply is continued.   The detector for detecting the concentration of decontamination gas is provided in the isolator, and switching from the first operating state to the second operating state is performed based on a signal of the detector. The isolator system as described in.   2. The isolator system according to claim 1, wherein the isolator system is switched to the second operation state after a lapse of a predetermined time from the first operation state.   The isolator system according to any one of claims 1 to 3, wherein the opening / closing door is switchable between a large open state and a small open state.   The air supply means and the incubator are connected via an open / close valve, and air is supplied from the air supply means to the incubator in the first operating state and the second operating state. Item 5. The isolator system according to any one of Items 1 to 4.

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