JP2015128744A - Concentrator - Google Patents

Abstract

PROBLEM TO BE SOLVED: To suppress the bumping of a chemical agent in a storage container with no decrease in cleanliness of the chemical agent in the storage container.SOLUTION: A concentrator 1, which is a concentrator comprising a storage container 3 that stores a chemical agent 4 containing a solvent, a decompression part 5 that can decompress the interior of the storage container 3, and a line L1 that connects the storage container 3 with the decompression part 5 and evaporating the solvent contained in the chemical agent 4 stored in the storage container 3 to concentrate the chemical agent 4 by decompressing the interior of the storage container 3 with the decompression part 5, keeps a gas supply part 7 that can supply a gas to the line L1 connected with the line L1 between the storage container 3 and the decompression part 5.

Description

  The present invention relates to a concentration device for concentrating a drug.

  Conventionally, for example, in the production of a PET drug, an organic solvent used in a synthesis reaction or the like is concentrated and dried with a concentrating device so that the organic solvent is not mixed into the final preparation. For example, in the concentration device described in Patent Document 1, the drug is concentrated by heating the drug containing the organic solvent under reduced pressure by using a vacuum pump to evaporate the organic solvent.

Japanese Patent Laid-Open No. 8-047602

  In the concentrating device described in Patent Document 1, if the container containing the medicine is evacuated rapidly, the medicine in the container may bump. As a result, there exists a problem that a chemical | medical agent will spread to the upper opening of a storage container.

  Therefore, it is required to suppress bumping of the medicine in the container, but it is difficult to directly adjust the pressure of the vacuum pump. Further, for example, a method of supplying gas into an organic solvent container and adjusting the pressure for evacuation may be considered. However, in this case, the cleanliness of the medicine in the container may be reduced by the inflow of gas. is there.

  Then, an object of this invention is to provide the concentration apparatus which can suppress the bumping of the chemical | medical agent in a storage container, without reducing the cleanliness of the chemical | medical agent in a storage container.

  In order to solve the above problems, a concentrating device according to the present invention includes a storage container for storing a medicine containing a solvent, a decompression unit capable of decompressing the interior of the storage container, and a line connecting the storage container and the decompression unit. A concentration device that evaporates the solvent contained in the medicine contained in the container and concentrates the medicine by depressurizing the inside of the container by the decompression unit, and in a line between the container and the decompression unit Is characterized in that a gas supply unit capable of supplying gas to the line is connected.

  In the concentrator according to the present invention, the gas supply unit supplies the gas to the line between the storage container and the decompression unit, so the decompression unit decompresses the storage container according to the amount of gas supplied to the line. The amount of pressure applied can be adjusted. As a result, bumping of the medicine in the container can be suppressed. Moreover, since the gas supply part is connected to the line between the storage container and the decompression part, it can suppress that the cleanliness | purity of the chemical | medical agent in a storage container falls by the gas supplied from a gas supply part. As described above, the bumping of the medicine in the container can be suppressed without reducing the cleanliness of the medicine in the container.

  Moreover, in the concentration apparatus according to the present invention, the suction capacity of the decompression unit may be constant during concentration in which the drug is concentrated. In this case, it is suitable for adjusting the magnitude of the pressure at which the container is decompressed by the decompression unit by the gas supply unit.

  Further, in the concentrating device according to the present invention, a cooling trap that cools a component generated by evaporation of the solvent contained in the medicine and collects it as a liquid is provided in the line, and the gas supply unit includes: You may connect between the cooling trap and the pressure reduction part. In this case, since the component generated by the evaporation of the solvent contained in the medicine is collected as a liquid by the cooling trap, the component can be prevented from flowing into the decompression unit. In addition, since the gas supply unit is connected to the line between the cooling trap and the decompression unit, the gas supplied from the gas supply unit can be prevented from flowing into the cooling trap. Therefore, the component can be collected without affecting the solidification rate in the cooling trap, and as a result, the component can be more reliably suppressed from flowing into the decompression unit.

  ADVANTAGE OF THE INVENTION According to this invention, the concentration apparatus which can adjust the pressure reduction degree in a storage container can be provided, without reducing the cleanliness of the chemical | medical agent in a storage container.

It is a figure which shows schematic structure of the concentration apparatus which concerns on one Embodiment of this invention. It is a figure which shows schematic structure of the concentration apparatus which concerns on a 1st comparative example. It is a figure which shows schematic structure of the concentration apparatus which concerns on a 2nd comparative example.

  Hereinafter, a neutron capture therapy apparatus according to the present invention will be described with reference to the accompanying drawings. In the description of the drawings, the same elements are denoted by the same reference numerals, and redundant description is omitted.

First, the outline | summary of the concentration apparatus which concerns on one Embodiment of this invention is demonstrated using FIG. As shown in FIG. 1, the concentration apparatus 1 is an apparatus that is connected to, for example, a radiopharmaceutical manufacturing apparatus 10 and concentrates and solidifies an organic solvent contained in the drug manufactured by the radiopharmaceutical manufacturing apparatus 10. Radiopharmaceutical production apparatus 10, for example ¹⁸ F-FLT used for PET examination such as a hospital (positron tomography inspection) or the like (fluoro ^thymidine), 18 F-FMISO (fluoro Sony ^imidazole), 11 ^{C-raclopride, 11} It is an apparatus for producing radiopharmaceuticals (including radiopharmaceuticals) which are radioisotope labeled compounds (RI compounds) such as C-methionine and ¹¹ C-acetic acid. The concentrating device 1 is connected to the radiopharmaceutical manufacturing apparatus 10 via a line L4. The component such as the line L1 connecting the container 3 and the decompression unit 5, the gas supply unit 7 capable of supplying gas to the line L1, and the vapor generated in the container 3 is cooled and collected as a liquid. And a cooling trap 9. The line L4 has a valve 15. The valve 15 is opened when the medicine produced by the radiopharmaceutical production apparatus 10 is introduced into the container 3 and is closed after the introduction.

  Any container can be used as the container 3 as long as it can accommodate the drug 4, but a round bottom flask is employed in the example shown in the figure. The storage container 3 includes an opening 3a, a storage 3b that communicates with the opening 3a, a liquid tube 3c that introduces the medicine 4 manufactured by the radiopharmaceutical manufacturing apparatus 10 into the storage 3b, and a storage container 3b. It has 3 d of gas pipes which make gas flow in and out, and the cover part 3e attached to the opening part 3a. The accommodating part 3b is formed in the spherical shape whose diameter is larger than the opening part 3a. The container 3b stores the drug 4, and the drug 4 includes an organic solvent used for a synthesis reaction or the like in the manufacture of the PET drug. The storage container 3 is sealed by the lid 3e after storing the medicine 4.

  The decompression unit 5 is, for example, a vacuum pump that can decompress the inside of the storage container 3. The decompression unit 5 decompresses the inside of the container 3 by evacuation, evaporates the organic solvent contained in the medicine 4, and removes the evaporated organic solvent by suction. As a result, the organic solvent is removed from the drug 4 and the drug 4 is concentrated. In the present embodiment, when the drug 4 is concentrated, the decompression unit 5 is driven so that the suction capability of the decompression unit 5 is constant. The suction capacity is an ability defined as the value of the negative pressure generated by the decompression unit 5. As the decompression unit 5, a suction capacity of, for example, about −80 kPa to −100 kPa is employed.

  The line L1 includes a line L2 between the storage container 3 and the cooling trap 9, and a line L3 between the cooling trap 9 and the decompression unit 5. The line L <b> 3 has a valve 11 between the cooling trap 9 and the gas supply unit 7, and has a valve 13 between the gas supply unit 7 and the decompression unit 5. The valves 11 and 13 are opened when evacuation is performed by the decompression unit 5, and are closed when evacuation by the decompression unit 5 is stopped. The valves 11 and 13 may remain open without being closed when evacuation by the decompression unit 5 is stopped, but the gas supply unit 7 is closed by closing the valve 11. Can be prevented from passing through the cooling trap 9 and the line L2 and being supplied to the container 3.

The gas supply unit 7 is connected to a line L <b> 1 between the storage container 3 and the decompression unit 5. The gas supply unit 7 supplies a gas such as He, N ₂ , and air to the line L1. The gas supply unit 7 includes a supply source (not shown) having a gas cylinder, a pump, and the like, a line 7a that leads gas from the supply source to the line L1, and a joint 7b that connects the line 7a to the line L1. The magnitude of the pressure at which the inside of the container 3 is decompressed by the decompression unit 5 is adjusted according to the amount of gas supplied. For example, when the gas supply amount is increased, the amount of pressure of the increased gas and the pressure at which the inside of the storage container 3 is depressurized are reduced. When the gas supply amount is decreased, the reduced gas pressure and the storage container The amount of pressure at which the inside of 3 is depressurized increases. Since the evacuation is performed by the decompression unit 5, the gas supplied from the gas supply unit 7 to the line L <b> 1 does not flow into the storage container 3.

  In particular, in the present embodiment, the gas supply unit 7 is connected between the cooling trap 9 and the decompression unit 5 in the line L1, that is, the line L3. The gas from the gas supply unit 7 is supplied to the line L3. Since vacuuming is performed by the decompression unit 5, the gas supplied from the gas supply unit 7 to the decompression unit 5 does not flow to the line L <b> 2 side, and there is no possibility of flowing into not only the storage container 3 but also the cooling trap 9.

  The cooling trap 9 is provided in a line L <b> 1 connecting the container 3 and the decompression unit 5. The cooling trap 9 collects components such as vapor generated by evaporation of the organic solvent contained in the medicine 4 in the container 3 through the gas pipe 3d, cools the components, and collects them as a liquid. Thereby, the cooling trap 9 prevents components such as steam generated in the storage container 3 from flowing into the decompression unit 5.

  Next, with reference to FIG.2 and FIG.3, the effect | action and effect of the concentration apparatus 1 which concern on this embodiment are demonstrated. FIG. 2 is a schematic configuration diagram illustrating the concentrating device according to the first comparative example. FIG. 3 is a schematic configuration diagram illustrating a concentrating device according to a second comparative example.

  First, the concentration apparatus 100 according to the first comparative example shown in FIG. 2 and the concentration apparatus 1 according to the present embodiment will be compared and described. As shown in FIG. 2, the concentrating device 100 does not include the gas supply unit 7 unlike the concentrating device 1 according to the present embodiment. In such a concentrator 100, when the decompression unit 5 suddenly depressurizes the container 3, the medicine 4 in the container 3 may bump. As a result, there exists a problem that the chemical | medical agent 4 in the accommodating part 3b will scatter to the upper part (For example, the range ranging from the opening part 3a to the cover part 3e). If the drug 4 is scattered, the recovery amount as the final preparation to be administered to the patient may be reduced accordingly.

  In addition, the drug 4 stored in the storage part 3b of the storage container 3 is dissolved by the physiological saline introduced into the storage part 3b and recovered as a final preparation in the step after the organic solvent is concentrated and dried. The However, it is generally required to reduce the amount of the physiological saline used so that the concentration as a final preparation to be administered to a patient does not become too thin. For this reason, for example, when the amount of physiological saline with respect to the capacity of the storage container 3 is small, the liquid level of the physiological saline cannot reach the upper part of the storage container 3, and the physiological saline is placed on the upper part of the storage container 3. Water may not be in contact. That is, if the medicine 4 is scattered on the upper part of the container 3, the scattered medicine 4 is dissolved in physiological saline and cannot be recovered and remains, so the operator takes the container 3 by hand. There is a risk that it will be difficult to perform operations such as washing.

On the other hand, the concentration apparatus 1 according to the present embodiment includes the gas supply unit 7, and a gas such as N ₂ is supplied to the line L 1 by the gas supply unit 7. Thereby, the magnitude | size of the pressure by which the pressure in the storage container 3 is pressure-reduced by the pressure reduction part 5 can be adjusted according to the supply_amount | feed_rate of the gas to the said line L1. As a result, bumping of the medicine 4 in the container 3 can be suppressed, so that the possibility that the medicine 4 is scattered on the upper part of the container 3 can be reduced. Therefore, the collection amount of the final preparation can be stabilized, and the operator can easily perform operations such as washing of the container 3.

  Next, the concentration apparatus 101 according to the second comparative example shown in FIG. 3 and the concentration apparatus 1 according to the present embodiment will be compared and described. As shown in FIG. 3, unlike the concentration device 1 according to the present embodiment, the concentration device 101 does not include the gas supply unit 7 connected between the storage container 3 and the decompression unit 5, and the storage container 3. Gas is supplied inside. In such a concentrating device 101, the gas supplied into the container 3 comes into contact with the medicine 4, so that the gas is required to have a high cleanliness. However, since a gas cylinder that supplies gas is repeatedly used, it is difficult to keep the cleanness of the gas supplied from the gas cylinder high. Therefore, in the concentrating device 101, gas with low cleanliness is introduced into the storage container 3, and the cleanliness of the medicine 4 in the storage container 3 may be reduced.

  On the other hand, in the concentration apparatus 1 according to the present embodiment, a gas supply unit 7 capable of supplying gas to the line L1 is connected to the line L1 between the storage container 3 and the decompression unit 5. Accordingly, gas is supplied from the gas supply unit 7 to the line L1. Since the gas is evacuated by the decompression unit 5, there is no possibility of flowing into the container 3. Thereby, a possibility that the cleanliness | purity of the chemical | medical agent 4 in the container 3 may fall can be suppressed. That is, it is possible to adjust the magnitude of the pressure at which the inside of the container 3 is depressurized by the decompression unit 5 without reducing the cleanliness of the medicine in the container 3.

  Furthermore, in the concentration apparatus 1 according to the present embodiment, the gas supply unit 7 is connected between the cooling trap 9 and the decompression unit 5 in the line L1, that is, the line L3. Therefore, it is possible to suppress the gas from the gas supply unit 7 from flowing into the cooling trap 9. Thereby, it is possible to collect components such as vapor generated by the evaporation of the organic solvent contained in the medicine 4 without affecting the solidification rate in the cooling trap 9. As a result, it can suppress more reliably that the said component flows into the pressure reduction part 5. FIG.

  As described above, in the concentrating device 1 according to the present embodiment, the gas is supplied to the line L1 by the gas supply unit 7. Therefore, the storage container 3 is depressurized by the decompression unit 5 in accordance with the amount of gas supplied to the line L1. The magnitude of the pressure can be adjusted. As a result, bumping of the medicine 4 in the container 3 can be suppressed. Further, since the gas supply unit 7 is connected to the line L1 between the storage container 3 and the decompression unit 5, the cleanliness of the medicine 4 in the storage container 3 is lowered by the gas supplied from the gas supply unit 7. This can be suppressed. Therefore, according to the concentrating device 1 according to the present embodiment, bumping of the medicine 4 in the container 3 can be suppressed without reducing the cleanliness of the medicine 4 in the container 3.

  Moreover, in the concentration apparatus 1 according to the present embodiment, the suction capacity of the decompression unit 5 is constant during the concentration in which the drug 4 is concentrated, and accordingly, the amount of gas supplied by the gas supply unit 7 is appropriately set. The magnitude of the pressure at which the container 3 is decompressed by the decompression unit 5 can be adjusted. Therefore, it is suitable for adjusting the magnitude of the pressure at which the container 3 is decompressed by the decompression unit 5 by the gas supply unit 7.

  Moreover, in the concentration apparatus 1 which concerns on this embodiment, the cooling trap 9 which cools components, such as a vapor | steam generate | occur | produced when the solvent contained in the chemical | medical agent 4 evaporates, and is collected as a liquid is provided in the line L1. Therefore, it can suppress that components, such as the said vapor | steam, flow into the decompression part 5 as a water | moisture content. Further, since the gas supply unit 7 is connected to the line L3 between the cooling trap 9 and the decompression unit 5, that is, the line L3, the gas supplied from the gas supply unit 7 flows into the cooling trap 9. Can be suppressed. Therefore, components such as the steam can be collected without affecting the solidification rate in the cooling trap 9, and as a result, the components such as the steam can be more reliably suppressed from flowing into the decompression unit 5 as moisture. it can.

  The preferred embodiments of the present embodiment have been described above. However, the present invention is not limited to the above-described embodiments. The present invention is not limited to the gist described in each claim and can be modified or applied to others. It may be what you did.

  For example, in the above embodiment, the gas supply unit 7 is connected between the cooling trap 9 and the decompression unit 5 in the line L1, that is, connected to the line L3, but is not limited thereto. For example, the gas supply unit 7 may be connected between the container 3 and the cooling trap 9 in the line L 1, that is, connected to the line L 2, or may be connected to the cooling trap 9. Even in this case, gas is supplied from the gas supply unit 7 to the line L2 or the cooling trap 9, and the gas is evacuated by the decompression unit 5, so there is no possibility of flowing into the storage container 3. Therefore, the possibility that the cleanliness of the medicine 4 in the storage container 3 is reduced can be suppressed.

  Moreover, the cooling trap 9 does not necessarily need to be provided. In addition, when the drug 4 is concentrated, the suction capability of the decompression unit 5 is not necessarily constant.

  Moreover, the kind of gas supplied by the gas supply part 7 is not restricted to what was mentioned in the said embodiment.

  The operations of the valves, the decompression unit, and the gas supply unit are controlled by a control unit (not shown).

DESCRIPTION OF SYMBOLS 1 ... Concentrator, 3 ... Container, 4 ... Drug, 5 ... Depressurization part, 7 ... Gas supply part, 9 ... Cooling trap, L1 ... Line.

Claims (3)

A container for containing a drug containing a solvent;
A decompression section capable of decompressing the inside of the container,
A line connecting the container and the decompression unit;
A concentration device for concentrating the drug by evaporating the solvent contained in the drug contained in the container by depressurizing the inside of the container by the decompression unit,
The concentrating device, wherein a gas supply unit capable of supplying gas to the line is connected to the line between the container and the decompression unit. At the time of concentration in which the drug is concentrated, the suction capacity of the decompression unit is constant.
The concentration apparatus according to claim 1. A cooling trap is provided in the line for cooling the component generated by the evaporation of the solvent contained in the drug and collecting it as a liquid,
The gas supply unit is connected between the cooling trap and the decompression unit in the line.
The concentration apparatus according to claim 1 or 2.

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