JP2015078134A - Scalp and hair cosmetic compositions - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide cosmetic compositions which have a high hair growing effect even with reduced amounts of pyrimidine oxide derivatives used.SOLUTION: The compositions contain pyrimidine oxide derivatives represented by the general formula (I) in the figure, and amino acid based surfactants.

Description

  The present invention relates to a scalp having a hair growth promoting effect and a cosmetic composition for hair.

  Conventionally, various active ingredients are blended in pharmaceuticals, quasi-drugs, cosmetics and the like for the purpose of preventing and treating diseases occurring in the scalp and hair. For example, Patent Document 1 describes that 6- (1-piperinidyl) -2,4-diaminopyrimidine 3-oxide (common name: minoxidil) has hair growth and hair restoration action, and hair growth that contains minoxidil. Agents are also widely available commercially. The mechanism of hair growth promotion by minoxidil has not yet been elucidated, but is thought to be caused by vasodilation by the potassium channel opening effect.

  For example, Patent Document 2 reports that the concentration of minoxidil in blood can be increased by applying a hair-restoring composition containing minoxidil at a high concentration to the scalp. Patent Document 2 discloses that the skin absorption of minoxidil is enhanced and the feeling of use is enhanced by not including a surfactant in the composition.

  It has been reported that pyrimidine oxide derivatives other than minoxidil have the same hair-growth effect as minoxidil. For example, in Patent Document 3, 6- (1-pyrrolidinyl) -2,4-diaminopyrimidine 3-oxide (hereinafter abbreviated as “PDPO”) exhibits a potassium channel opening effect and is in a resting mouse. It has been reported that it has the effect of promoting the transition of the hair growth cycle to the growth phase.

US Pat. No. 4,139,619 WO01 / 076541 International Publication Pamphlet International publication pamphlet of WO2007 / 046577

  As described above, pyrimidine oxide derivatives are known to have a high hair growth effect. However, when the concentration of the pyrimidine oxide derivative in an aqueous liquid such as a cosmetic composition becomes high, there is a problem that crystals are precipitated when stored at a low temperature for a long time. In addition, it is known that pyrimidine oxide derivatives such as minoxidil may cause side effects such as scalp itching, inflammation, eczema, and seborrheic dermatitis. Therefore, a cosmetic composition having a high hair growth effect is desired even when the amount of pyrimidine oxide derivative used is reduced.

  In view of the above, as a result of intensive studies by the present inventors, it has been found that a composition containing a pyrimidine oxide derivative and a predetermined surfactant exhibits a high hair growth effect, leading to the present invention. That is, the present invention relates to a scalp and hair cosmetic composition containing a pyrimidine oxide derivative and an amino acid surfactant.

  As the pyrimidine oxide derivative, a 2,4-diaminopyrimidine 3-oxide derivative represented by the following general formula (I) is preferable.

  In the general formula (I), NR5R6 is a substituent at the 5th or 6th position of pyrimidine. In the general formula (I), R1 to R6 each independently represent a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an aryl group, or an aralkyl group, and R1 and R2, R3 and R4, and R5 Each of R6 may be linked to form a ring structure. NR5R6 of the general formula (I) is preferably a 1-pyrrolidinyl group which may have a substituent or a 1-piperidinyl group which may have a substituent.

  As the amino acid surfactant, glutamic acid ester or glutamic acid salt, pyroglutamic acid ester or pyroglutamic acid salt is preferable.

  In the cosmetic composition of the present invention, the content of the amino acid surfactant is preferably larger than the content of the pyrimidine derivative. The content of the pyrimidine derivative is, for example, about 0.01 to 3% by weight. The content of the amino acid surfactant is preferably 0.8 to 8% by weight.

  The cosmetic composition of the present invention can exhibit a high hair growth effect even when the content of the pyrimidine oxide derivative is small.

It is a graph showing the hair growth test result in Experiment 1 and Experiment 2. It is a graph showing the hair growth test result in Experiment 3 and Experiment 4. It is a graph showing the hair growth test result in Experiment 5. It is a photograph of the back part of the mouse | mouth of the hair growth test using the composition of an Example. It is a photograph of the back part of the mouse | mouth of the hair growth test using the composition of a comparative example.

  The scalp and hair cosmetic composition of the present invention contains a pyrimidine oxide derivative and a surfactant.

[Pyrimidine oxide derivatives]
The pyrimidine oxide derivative in the cosmetic composition of the present invention is preferably a 2,4-diaminopyrimidine 3-oxide derivative represented by the following general formula (I).

  In the general formula (I), NR5R6 is a substituent at the 5th or 6th position of pyrimidine. In the general formula (I), R1 to R6 each independently represent a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an aryl group, or an aralkyl group, and R1 and R2, R3 and R4, and R5 Each of R6 may form a ring structure.

  R1 to R4 may be the same or different. Preferably, all of R1 to R4 are hydrogen atoms.

  R5 and R6 may be the same or different. In the pyrimidine oxide derivative used in the present invention, preferably, as represented by the following general formula (II), R5 and R6 are linked to form a ring structure (heterocycle).

  In the general formula (II), the heterocycle bonded to the pyrimidine oxide is preferably a 1-pyrrolidinyl group or a 1-piperidinyl group. Arbitrary substituents may be present on the pyrrolidine ring or piperidine ring. The heterocycle is preferably bonded to the 6-position of the pyrimidine.

  That is, in a particularly preferred form of the present invention, the pyrimidine oxide derivative used in the cosmetic composition is a 6- (1-piperidinyl) -2,4-diaminopyrimidine 3-oxide (minoxidil) represented by the following formula (III): Or 6- (1-pyrrolidyl) -2,4-diaminopyrimidine 3-oxide (PDPO) represented by the following formula (IV).

[Surfactant]
The surfactant in the cosmetic composition of the present invention is an amino acid surfactant. The amino acid surfactant is an amino acid derivative and is not particularly limited as long as it acts as a surfactant, and examples thereof include those in which an amino acid and a higher alcohol are amide-bonded. The amino acid may be either L-type or D-type, and may be a natural amino acid or a synthetic amino acid.

  Specific examples of the amino acid surfactant include N-acyl-glutamic acid or a salt thereof, N-acylalanine or a salt thereof, N-acylglycine or a salt thereof, N-acyl aspartic acid or a salt thereof, arginine higher alcohol ester or Salts thereof, pyroglutamic acid esters or salts thereof, N-acyl-N-methyl-β-alanine or salts thereof (for example, “Alanon ACE”, “Alanon ALE”, “Alanon ALK”, “Alanon ALTA” manufactured by Kawasaki Fine Chemical, “Alanon AME”, “Alanon AMP”, “Alanon ACA”, “Alanon ALA”, “Alanon AMA”, etc.), N-acyl neutral amino acid ester (for example, hexyldecyl myristoylmethylaminopropionate (product made in Japan Emulsion) The name “Ami” MA-HD "), N-acyl glutamic acid esters (for example, product names" Amitel LG "series," Amitel SG "series," Amitel LGOD "series," Amitel LGS "series, etc., manufactured by Nippon Emulsion)) And amino acid salts such as pyroglutamate are used.

  Examples of the N-acyl-glutamic acid or a salt thereof include coconut oil fatty acid acyl-glutamic acid or a salt thereof (for example, product names “Amisoft CT-12”, “Amisoft CT-12S”, “Amisoft CT-12S” manufactured by Ajinomoto Healthy Supply Co., Ltd.) "CK-22", "Amisoft CS-22", "Amisoft CS-11", "Amisoft CS-11 (F)", "Amisoft CK-11 (F)", "Amisoft CA"; product names manufactured by Asahi Kasei Chemicals “Amino Surfact ACDS-L”, “Amino Surfact ACDP-L”, “Amino Surfact ACMT-L”, “Amino Surfact CCA”; Product names “Kyowa Hakko Bio” “Form Up Dose-GM”, “ Foam-up GA "); lauroyl-glutamic acid or The salt (for example, “Amisoft LT-12”, “Amisoft LK-11 (F)”, “Amisoft LS-11 (F)”, “Amisoft LA-D” manufactured by Ajinomoto Healthy Supply; products manufactured by Asahi Kasei Chemicals Name “Amino Surfact ALMS-P1”, “Amino Surfact ALMS-S1”); Myristoyl-glutamic acid or a salt thereof (for example, product names “Amisoft MK-11”, “Amisoft MS-11” manufactured by Ajinomoto Healthy Supply, “Amisoft MS-11 (F)”; product names “Amino Surfact AMMS-P1” and “Amino Surfact AMMS-S1” manufactured by Asahi Kasei Chemicals); stearoyl-glutamic acid or a salt thereof (for example, manufactured by Ajinomoto Healthy Supply Co., Ltd.) Product name “Amisoft HS-11P”, “A Soft HS-11P (F) "," Amisoft HA-P "); palm fatty acid glutamic acid or a salt thereof (for example, product names" Amisoft GS-11P "," Amisoft GS-11P (F) "manufactured by Ajinomoto Healthy Supply), “Amisoft HA-P”; product names “Amino Surfact AEMS-P2”, “Amino Surfact AEMS-PB”) manufactured by Asahi Kasei Chemicals; other acyl-glutamic acids or salts thereof), and the like.

  Examples of the N-acylalanine or a salt thereof include N-coconut oil fatty acid acyl-alanine or a salt thereof (for example, product names “Amisoft ACT-12” and “Amilite ACS-12” manufactured by Ajinomoto Healthy Supply), etc. Is mentioned.

  Examples of the N-acylglycine or the salt thereof include N-coconut oil fatty acyl-glycine or a salt thereof (for example, product names “Amilite GCK-11”, “Amilite GCK-12”, Amylite GCK-12K "," Amlite GCS-11 ") and the like.

  Examples of the N-acyl arginine or a salt thereof include N-coconut oil fatty acid acyl-arginine or a salt thereof (for example, product name “Amino Soap AR-12” manufactured by Ajinomoto Healthy Supply).

  Examples of the N-acyl aspartic acid or a salt thereof include, for example, lauroyl aspartic acid or a salt thereof (for example, product names “Amino Former FLDS-L”, “Amino Former FLMS-P1”, “Amino Former” manufactured by Asahi Kasei Chemicals Corporation). Former FLCS-s1 ") and the like.

  As the above arginine higher alcohol ester or a salt thereof, for example, N- [3-alkyl (12,14) oxy-2-hydroxypropyl] -arginine or a salt thereof (for example, product name “Amisafe LMA manufactured by Ajinomoto Healthy Supply Co., Ltd.) -60 ") and the like.

  Examples of the pyroglutamic acid ester or a salt thereof include pyroglutamic acid isostearic acid polyoxyethylene hydrogenated castor oil (for example, product names “PYROTEL CPI-30”, “PYROTEL CPI-40”, “PYROTEL CPI-60” manufactured by Japan Emulsion). ) And pyroglutamic acid isostearate polyoxyethylene glyceryl (for example, product name “Pyrotel GPI-25” manufactured by Nippon Emulsion Co., Ltd.).

  Examples of the pyroglutamate include N-coconut oil fatty acid acyl-arginine ethyl pyroglutamate (for example, product name “CAE” manufactured by Ajinomoto Healthy Supply).

  Among the amino acid surfactants, acidic amino acid salts, acidic amino acid esters or salts thereof are preferably used. Examples of the salt of acidic amino acid include glutamate, aspartate, pyroglutamate and the like. Examples of the acidic amino acid ester include glutamic acid ester, aspartic acid ester, pyroglutamic acid ester and the like. Among these, pyroglutamate, pyroglutamate or a salt thereof is particularly preferable.

  The salt of acidic amino acid is preferably a salt of acidic amino acid and amino acid ester. In addition, even if an amino acid ester or an acidic amino acid salt (for example, sodium pyroglutamate) that does not have an action as a surfactant is blended, an improvement in the hair growth effect cannot be expected. It is necessary to use what acts as a surfactant.

[Combination]
The cosmetic composition of the present invention contains the above pyrimidine oxide derivative and a surfactant. The content of the pyrimidine oxide derivative in the cosmetic composition is preferably 0.01% by weight to 3% by weight, more preferably 0.1 to 2% by weight, and still more preferably 0.3 to 1.5% by weight. 0.6 to 1.2% by weight is particularly preferable. If the content of the pyrimidine oxide derivative is too small, a sufficient hair growth effect may not be obtained. When the content of the pyrimidine oxide derivative is excessively large, problems such as precipitation of pyrimidine oxide derivative crystals in the cosmetic composition, and side effects such as scalp itchiness and inflammation may occur.

  Since the cosmetic composition of the present invention contains an amino acid surfactant, a high hair growth effect can be achieved even when the content of the pyrimidine oxide derivative is 3% by weight or less. Further, in the cosmetic composition of the present invention, even if the content of the pyrimidine oxide derivative is more than 1.5% by weight, no significant hair growth effect is observed. Therefore, the content of the pyrimidine oxide derivative is preferably within the above range from the viewpoint of reducing side effects and cost.

  In the cosmetic composition of the present invention, plural types of pyrimidine oxide derivatives can be used in combination. For example, both minoxidil and PDPO may be contained in the cosmetic. When using multiple types of pyrimidine oxide derivatives, the total amount is preferably within the above range.

  The content of the amino acid surfactant in the cosmetic composition is preferably 0.6 to 8% by weight, more preferably 0.8 to 6% by weight, and still more preferably 1.0 to 5% by weight. In addition, when using pyroglutamic acid ester as an amino acid type surfactant, the content thereof is preferably 1.0 to 8% by weight, more preferably 2 to 6% by weight, and further preferably 2.5 to 5% by weight. . In the cosmetic composition of the present invention, an amino acid surfactant can be used in combination. When using an amino acid surfactant, the total amount is preferably within the above range.

  If the content of the amino acid surfactant is too small, a sufficient hair growth effect may not be obtained. On the other hand, even if the content of the amino acid surfactant is excessively increased, the hair growth effect is not improved, and the scalp tends to be uncomfortable during use.

  In the cosmetic composition of the present invention, the content of the amino acid surfactant is preferably larger than the content of the pyrimidine derivative. By increasing the content of the amino acid surfactant, the hair growth effect by the pyrimidine derivative tends to be promoted. The content of the amino acid surfactant is more preferably 1.2 times or more, and further preferably 1.5 times or more that of the pyrimidine derivative.

  The cosmetic composition of the present invention can be prepared by dissolving the pyrimidine derivative and the amino acid surfactant in water, alcohols such as ethanol, or a mixed solvent thereof.

  The cosmetic composition of the present invention includes various raw materials used for cosmetics, for example, surfactants other than those described above, hair growth promoting components, celluloses, esters, vegetable oils, as long as the objects and effects of the present invention are not impaired. , Alcohols, keratolytic agents, transdermal absorption enhancers, UV absorbers, amino acids, anti-inflammatory agents, skin function enhancers, antibacterial agents, cooling agents, water-soluble polymers, antiseptics, solubilizers, pH adjusters , Viscosity modifiers, colorants, fragrances and the like may be included.

  The hair growth promoting component is a medicinal component other than the above-mentioned pyrimidine derivatives, such as mulberry bark extract, eucalyptus extract, yeast extract, japonica extract, aloe extract, pepper extract, peppermint extract, musk extract, wasabi extract, yuzu extract, Biwa leaf extract, tea extract, camellia extract, Roman chamomile extract, rosemary extract, brown algae extract, daisies flower extract, peach leaf extract, nematode extract, tamasaki tsutsu rafuji root extract, maca extract, pine licorice extract, peony skin extract, licorice extract , Plant-derived components such as carrot extract, black bean extract, yokuinin extract, argania spinosa blast cell extract, placenta extract, various vitamins, collagen, hyaluronic acid, hematin, cephalanthin, L-menthol, etc. Limited to It is not a thing. These hair growth promoting components may be blended with a single component or in combination of two or more.

  The pH of the cosmetic composition of the present invention is not particularly limited, but the pH at 25 ° C. is preferably in the range of 3.0 to 9.0 from the viewpoint of reducing irritation to the scalp. For example, the pH of the cosmetic composition can be adjusted to a desired value by using an alkali such as potassium hydroxide or sodium hydroxide, an acid such as lactic acid or citric acid, or a salt thereof.

[Usage]
Since the cosmetic composition of the present invention may have an effect of promoting hair growth or hair growth when applied to the scalp or hair, such as hair growth lotion, hair growth spray, hair growth tonic, hair growth gel, hair growth liquid, hair growth cream, etc. It can be suitably used as a hair nourishing agent or hair restoring agent.

  Hereinafter, the present invention will be described in more detail using experimental examples of hair growth tests using mice, but the present invention is not limited to the following examples.

[Hair growth test and evaluation method]
One group of 7-week-old male C3H mice was 5 (however, 4 in the control test), and the back of each mouse was removed with an electric clipper and an electric shaver. The sample composition (solution) was applied to the back of the mouse once a day (application amount: 0.2 mL per sample), 5 days a week for about 2 months, and the hair was regularly observed visually. The reproduction situation was observed and a photo was taken. Based on the photographed photos, the degree of hair growth was scored according to the following criteria, and the average value of each group was determined.

<Score criteria>
0: A state in which no hair grows in the hair removal part.
1: A state in which hair growth is observed in an area of 0 to 20% of the hair removal part.
2: A state in which hair growth is observed in an area of 20 to 40% of the hair removal portion.
3: A state in which hair growth is observed in an area of 40 to 60% of the hair removal part.
4: A state in which hair growth is observed in an area of 60 to 80% of the hair removal part.
5: A state in which hair growth is observed in an area of 80% or more of the hair removal part.

[Experiment 1]
<Example 1-1>
Scalp lotion (50% aqueous solution of ethanol containing crude drugs), 0.8% by weight of 6- (1-pyrrolidinyl) -2,4-diaminopyrimidine 3-oxide (PDPO), and polyoxyethylene glyceryl-25, pyroglutamate isostearate (Nippon Emulsion Co., Ltd., product name “Pirotel GPI-25”) was added to prepare a cosmetic composition by adding 3.5% by weight. A hair growth test was performed using this composition. Note that pyrotel GPI-25 used as the surfactant is a pyroglutamate represented by the following chemical formula (average value of a + b + c≈25).

<Comparative Example 1>
An aqueous ethanol solution containing PDPO: 1.0% by weight was prepared, and a hair growth test was performed using this composition.

<Comparative Example 2>
An aqueous ethanol solution containing PDPO: 1.4% by weight was prepared, and a hair growth test was performed using this composition. In Comparative Example 2, the coating amount at the time of the hair growth test was 0.6 mL (three times that of the other examples) at a time.

<Reference Example 1>
A hair growth test was carried out using a commercially available hair growth composition containing 5% by weight of minoxidil (product name “Reup X5” manufactured by Taisho Pharmaceutical Co., Ltd.).

<Control 1>
As a control test, a hair growth test was performed using an aqueous ethanol solution.

[Experiment 2]
<Example 1-2>
A hair growth test was performed using the same composition as in Example 1-1.

<Example 2 and Example 3>
Using the same composition as in Example 1-1, except that the PDPO content was increased to 1.4% by weight (Example 2) or decreased to 0.4% by weight (Example 3). A hair test was performed.

[Evaluation of Experiment 1 and Experiment 2]
Table 1-1 shows the compositions of the cosmetics used in Examples, Comparative Examples and Reference Examples of Experiment 1 and the results of the hair growth test. The composition of the cosmetic used in each Example of Experiment 2 and the results of the hair growth test are shown in Table 1-2. Moreover, the result of the hair growth test of Experiment 1 and Experiment 2 is shown in FIG. 1-1.

  As shown in Table 1-1 and FIG. 1-1, Example 1-1 containing PDPO and an amino acid-based surfactant and Reference Example 1 containing 5% by weight of minoxidil were 67 days after the start of the test. The hair growth results were comparable. From this result, even when the content of the 2,4-diaminopyrimidine 3-oxide derivative is 1% by weight or less by adding an amino acid surfactant, it is as high as a cosmetic containing 5% by weight of minoxidil. It turns out that it has a hair growth effect.

  On the other hand, Comparative Examples 1 and 2, which did not contain a surfactant, had a smaller hair growth effect than Examples and Reference Examples, despite having a higher PDPO content than Example 1-1. From these results, it can be seen that the hair growth effect of the 2,4-diaminopyrimidine 3-oxide derivative is improved by combining PDPO, which is a 2,4-diaminopyrimidine 3-oxide derivative, with an amino acid surfactant.

  From the comparison between Example 1-2 and Example 2 in Table 1-2, when an amino acid surfactant is contained, the content of PDPO is increased from 0.8% by weight to 1.4% by weight. However, there was no significant difference in the hair growth effect. On the other hand, when the PDPO content was reduced to 0.4% by weight, the hair growth effect tended to decrease.

[Experiment 3]
<Example 1-3>
A hair growth test was performed using the same composition as in Example 1-1.

<Example 4>
A hair growth test was carried out using the same composition as in Example 1-1 except that the content of the pyrotel GPI-25 was increased to 6.0% by weight.

<Comparative Example 3>
A hair growth test was conducted using the same composition as in Example 1-1 except that Pilotel GPI-25 was not added.

<Comparative Example 4>
Instead of Pilotel GPI-25, 4.0% by weight of polyoxyethylene hydrogenated castor oil (product name “Emalex HC-60” manufactured by Nippon Emulsion Co., Ltd.) as a surfactant and di-solvent as an auxiliary solvent for the surfactant A hair growth test was performed using the same composition as in Example 1-1 except that 3.0% by weight of propylene glycol was added.

[Experiment 4]
<Example 1-4>
A hair growth test was performed using the same composition as in Example 1-1.

<Example 5>
A hair growth test was carried out using the same composition as in Example 1-1 except that the content of Pilotel GPI-25 was reduced to 1.0% by weight.

[Evaluation of Experiment 3 and Experiment 4]
Table 2-1 shows the compositions of the cosmetics used in Examples 3 and Comparative Example and the results of the hair growth test. Table 2-2 shows the composition of the cosmetic used in each Example of Experiment 4 and the results of the hair growth test. Moreover, the result of the hair growth test of Experiment 3 and Experiment 4 is shown in FIG.

  In addition, photographs of the back of each mouse 32 days and 75 days after the start of the test of Example 1-3 and Comparative Example 3 are shown in FIGS. 2 and 3, respectively. The score of the mouse after 32 days in FIG. 2 (Example 1-3) is 2,0,1,1,1 from the top, and the score of the mouse after 75 days is 4, 5, 2, 5, from the top. 5. The score of the mouse after 32 days in FIG. 3 (Comparative Example 3) is 1,0,0,0,1 from the top, and the score of the mouse after 75 days is 1,5,3,1,1 from the top. is there.

  In the comparison between Example 1-3 and Example 4 in Table 2-1, even if the amount of the amino acid surfactant was increased, no clear difference was observed in the hair growth effect (see FIG. 1-2). On the other hand, from the comparison between Example 1-4 and Example 5 shown in Table 2-2, when the content of the amino acid surfactant was decreased to 1% by weight, the hair growth effect tended to decrease. . Moreover, in the comparative example 3 which does not contain surfactant, the hair growth effect was reducing significantly. Since the hair growth effect was reduced in Comparative Example 3 containing PDPO and herbal medicine, the above-mentioned Comparative Examples 1 and 2 (without herbal medicine) showed a reduction in hair growth effect compared to Example 1-1. Is mainly due to the presence or absence of an amino acid-based surfactant and is considered to have a low relevance to the presence or absence of a crude drug.

  Comparative Example 4 using a non-amino acid surfactant had inferior hair growth results compared to each Example, and was comparable to Comparative Example 3 in which no surfactant was used. From these results, it is considered that the hair growth effect is specifically increased by a combination of a hair growth component such as PDPO and an amino acid surfactant.

[Experiment 5]
<Example 1-5>
A hair growth test was performed using the same composition as in Example 1-1.

<Example 6>
Example 1-1 and Example 1-1 except that 1.0% by weight of cocoyl arginine ethyl pyroglutamate (product name “CAE” manufactured by Ajinomoto Healthy Supply Co., Ltd.) was added as a surfactant in place of Pilotel GPI-25. A hair growth test was performed using the same composition. CAE used as the surfactant is pyroglutamate represented by the following chemical formula (RCO: coconut oil fatty acid acyl).

<Example 7>
A commercially available hair-restoring composition containing 5% by weight of minoxidil (product name “Reup x5” manufactured by Taisho Pharmaceutical Co., Ltd.) is diluted with an aqueous ethanol solution so that the concentration of minoxidil is 1% by weight. A hair growth test was performed using the composition added to 3.5 wt%.

<Comparative Example 5>
Example except that in place of Pilotel GPI-25, 3.0% by weight of Emalex HC-60 as a surfactant and 2.0% by weight of dipropylene glycol as an auxiliary solvent for the surfactant were added. A hair growth test was performed using the same composition as 1-1.

<Comparative Example 6>
Implemented except that Emarex HC-60: 3.0% by weight was used as a surfactant instead of Pilotel GPI-25, and 0.3% by weight of pyroglutamic acid (pyrrolidonecarboxylic acid; PCA) was added. A hair growth test was conducted using the same composition as in Example 1-1.

<Comparative Example 7>
A hair growth test using a composition in which a commercially available hair growth composition containing 5% by weight of minoxidil (Taisho Pharmaceutical product name “Reup x5”) was diluted with an aqueous ethanol solution to a concentration of 1% by weight of minoxidil. Went.

<Control 2>
Similarly to Control 1, a hair growth test was performed using an aqueous ethanol solution.

[Evaluation of Experiment 5]
Table 3 shows the compositions of the cosmetics used in the examples of the experiment 5 and the comparative example, and the results of the hair growth test. Moreover, the result of the hair growth test of Experiment 5 is shown in FIGS. 1-3.

  In Example 6 using CAE which is an amino acid surfactant, a high hair growth effect was shown as in Example 1-5. On the other hand, Comparative Examples 5 and 6 using a non-amino acid surfactant were inferior in hair growth effect compared to each Example. Although the composition of the comparative example 6 contained pyroglutamic acid similarly to CAE used in Example 6, the hair growth effect was inferior (refer FIGS. 1-3). From this result, it can be seen that a high hair growth effect cannot be obtained by using a pyrimidine oxide derivative and an amino acid alone, and that the hair growth effect can be improved by using a pyrimidine derivative and an amino acid surfactant in combination.

  In Example 7, an amino acid activator was added to a 1% by weight solution of minoxidil (6- (1-piperidinyl) -2,4-diaminopyrimidine 3-oxide), compared to Comparative Example 7. The hair effect was improved. From this result, it is understood that the hair growth effect is improved by combining an amino acid surfactant with 2,4-diaminopyrimidine derivatives other than PDPO.

Claims (5)

A scalp and hair cosmetic composition containing a 2,4-diaminopyrimidine 3-oxide derivative represented by the following general formula (I) and an amino acid surfactant.
In the general formula (I),
NR5R6 is a substituent at the 5th or 6th position of the pyrimidine;
R1 to R6 each independently represent a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group, an aryl group, or an aralkyl group,
Each of R1 and R2, R3 and R4, and R5 and R6 may be linked to form a ring structure.   The cosmetic composition according to claim 1, wherein a content of the amino acid surfactant is larger than a content of the 2,4-diaminopyrimidine 3-oxide derivative.   The cosmetic composition according to claim 1 or 2, wherein the content of the amino acid surfactant is 0.6 to 8% by weight.   The cosmetic composition according to any one of claims 1 to 3, wherein the amino acid surfactant is glutamate or glutamate, or pyroglutamate or pyroglutamate.   In the 2,4-diaminopyrimidine 3-oxide derivative, the NR5R6 of the general formula (I) may have a 1-pyrrolidinyl group which may have a substituent, or 1-piperidinyl which may have a substituent. The cosmetic composition according to any one of claims 1 to 4, which is a group.