JP2014090670A - Injector for fertilized egg - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an injector for fertilized egg capable of improving a conception rate of fertilized egg by inhibiting discharging of the fertilized egg injected into corpus uteri from the corpus uteri.SOLUTION: A fertilized egg injector 1 for fertilized egg/sperm comprises: a guide tube 2 for insertion into corpus uteri, an injection tube 3 inserted into the guide tube 2, and a nozzle body 4 connected on the tip of the injection tube 3. In the inner section of the nozzle body 4, it is arranged: a first channel 46 which linearly extends from the end side to the tip side up to the middle position therebetween in a section from connection cylindrical part 42 to drum part 44; and a second channel 47 which obliquely and linearly extends from the first channel 46 to the tip side of the nozzle body 4 has an opening as a nozzle hole 48 on the side surface of the nozzle body 4. It is also arranged a stopper part 45 on the peripheral surface of the nozzle body 4, in which the size of external diameter is continuously enlarged from the end side to the tip side.

Description

  The present invention relates to a fertilized egg injector that injects a fertilized egg into the uterine body of an animal such as a cow.

  As an injector for injecting a fertilized egg into the uterine body of an animal such as a cow, as shown in FIGS. 4 (a) and 4 (b), a nozzle body is provided at the tip of a flexible injection tube 3a passed through a guide tube 2a. A concatenation of 4a has been proposed. In order to inject a fertilized egg using the fertilized egg injector 1a, the guide tube 2a is inserted into the uterus from the vaginal opening while the injection tube 3a is pulled into the guide tube 2a. Here, the portion of the nozzle body 4a where the nozzle hole 48a is formed is configured as a stopper portion 45a having an outer diameter larger than the inner diameter of the guide tube 2a so that the nozzle body 4a is not drawn into the guide tube 2a. Has been. Next, the injection tube 3a is drawn out from the tip of the guide tube 2a so that the nozzle body 4a reaches the deep part of the uterine horn. Then, after the fertilized egg supplied through the injection tube 3a is discharged from the nozzle hole 48a of the nozzle body 4a, the fertilized egg injector 1a is pulled out from the vaginal opening. In the fertilized egg injector 1a, the nozzle body 4a includes a tip part 43a rounded into a hemispherical shape, and a connecting cylinder part 42a protruding from the stopper part 45a toward the base end side, and the connecting cylinder part 42a. Is fitted inside the tip of the injection tube 3a, whereby the injection tube 3a and the nozzle body 4a are connected (see Patent Document 1).

  Further, as shown in FIG. 4C, the nozzle body 4a includes a first flow path 46a extending from the proximal end side of the nozzle body 4a toward the distal end side, and a distal end portion of the first flow path 46a. A second flow path 47a that extends in a direction perpendicular to the first flow path 46a and opens as a nozzle hole 48a on the side surface of the nozzle body 4a is formed. Therefore, the fertilized egg supplied through the injection tube 3a is injected into the uterus as shown by the arrow T through the first flow path 46a, the second flow path 47a and the nozzle hole 48a of the nozzle body 4a. .

Japanese Patent No. 3361778

  The inventor of the present application has examined various injectors including the fertilized egg injector 1a of the type described above and is considering further improvement of the conception rate. In the fertilized egg injector 1a described above, We are faced with the problem of not being able to improve the rate dramatically. In order to solve such a problem, the present inventor has made various studies, and as a result, the direction of the second flow path 47a formed in the nozzle body 4a (the opening direction of the nozzle hole 48a) hinders the improvement of the conception rate. Based on this knowledge, the present inventors have reached the present invention.

  Specifically, in the fertilized egg injector 1a shown in FIG. 4, the second flow path 47a extends in a direction perpendicular to the first flow path 46a, and the nozzle hole 48a extends to the side surface of the nozzle body 4a. It faces in a direction that is perpendicular. For this reason, when the fertilized egg is discharged from the nozzle body 4a, the fertilized egg is only released to the vicinity of the side of the nozzle body 4a, and thus the fertilized egg may flow backward to the nozzle body 4a. Further, as shown by an arrow P in FIG. 4C, when the injection tube 3a is pulled toward the proximal end, the fertilized egg S1 is caught on the edge of the nozzle hole 48a and scraped out from the uterus. is there. Therefore, the configuration shown in FIG. 4 has a problem that the conception rate tends to decrease.

  Moreover, in the fertilized egg injector 1a shown in FIG. 4, since the level | step difference 401a resulting from the stopper part 45a is formed, as shown by the arrow P in FIG.4 (c), the injection tube 3a is turned to the base end side. When pulled, the fertilized egg S2 may be caught by the step 401a and scraped out of the uterus.

  In view of the above problems, an object of the present invention is to provide a fertilized egg injector capable of improving the conception rate by suppressing the fertilized egg injected into the uterine body from being scraped from the uterine body. There is to do.

  In order to solve the above-described problems, the present invention provides a fertilized egg injector for injecting a fertilized egg into the uterine body, the injection tube having a flow path for supplying the fertilized egg, and a tip portion of the injection tube A nozzle body connected to the injection pipe, the nozzle body extending from the base end side connected to the injection tube to a middle position on the distal end side, and the first flow path from the first flow path And a second flow path extending obliquely toward the tip end side of the nozzle body and opening at a side surface of the nozzle body.

  In the fertilized egg injector according to the present invention, when the fertilized egg is supplied to the nozzle body via the injection tube, the fertilized egg passes through the first flow path and the second flow path formed in the nozzle body and enters the uterine body. Injected. Here, the second flow path extends obliquely from the first flow path toward the tip end side, and opens obliquely forward on the side surface of the nozzle body. For this reason, when the fertilized egg is discharged from the nozzle body, the fertilized egg is discharged to the front side from the position where the second flow path is opened, and further to the front side from the nozzle body. Therefore, it is difficult for the fertilized egg to flow backward to the nozzle body. In addition, when the injection tube is retracted to the proximal end side, it is possible to prevent the fertilized egg from being caught by the nozzle body or the opening edge of the second flow path and being scraped out from the uterus. Therefore, the conception rate can be improved.

  In the present invention, it is preferable that the nozzle body has only one second flow path. According to such a configuration, since the second flow path is opened at only one place on the side surface of the nozzle body, the fertilized egg is caught by the opening edge of the second flow path and is scraped out from the uterus to the outside. Can be more reliably suppressed.

  In the present invention, the injection tube has a guide tube that is passed through the inside, and the nozzle body has an outer diameter dimension that continuously increases from the proximal end side to the distal end side in the nozzle body, and the guide tube It is preferable to provide a stopper portion whose outer diameter is larger than the inner diameter. According to such a configuration, after the injection tube is drawn into the guide tube, the guide tube is inserted into the uterine body from the vaginal opening, and then the injection tube is extended from the tip of the guide tube so that the nozzle body reaches the deep part of the uterine body. Can do. In addition, after the fertilized egg is discharged from the nozzle body, the injection tube is drawn into the guide tube, and in this state, when the fertilized egg injector is pulled out from the vaginal opening, the nozzle body has an outer diameter larger than the inner diameter of the guide tube. Since the stopper portion is provided, the nozzle body is not pulled into the guide tube. In addition, the stopper part is composed of a part whose outer diameter is continuously enlarged from the base end side to the tip end side, and the nozzle body has a base end in a part from the connecting part to the injection pipe to the stopper part. There are no steps to the side. For this reason, the inner wall of the uterine body is not damaged by the step of the nozzle body. Moreover, since the fertilized egg is not caught by the step and scraped off, the conception rate can be improved.

  In the fertilized egg injector according to the present invention, when the fertilized egg is supplied to the nozzle body via the injection tube, the fertilized egg passes through the first flow path and the second flow path formed in the nozzle body and enters the uterine body. Injected. Here, the second flow path extends obliquely from the first flow path toward the tip end side, and opens obliquely forward on the side surface of the nozzle body. For this reason, when the fertilized egg is discharged from the nozzle body, the fertilized egg is discharged to the front side from the position where the second flow path is opened, and further to the front side from the nozzle body. Therefore, it is difficult for the fertilized egg to flow backward to the nozzle body. In addition, when the injection tube is retracted to the proximal end side, it is possible to prevent the fertilized egg from being caught by the nozzle body or the opening edge of the second flow path and being scraped out from the uterus. Therefore, the conception rate can be improved.

It is explanatory drawing of the fertilized egg injection device to which this invention is applied. It is explanatory drawing which shows the main components of the fertilized egg injector to which this invention is applied. It is explanatory drawing of the nozzle body used for the fertilized egg injection device to which this invention is applied. It is explanatory drawing of the conventional injector (fertilized egg injector).

  Embodiments of the present invention will be described with reference to the drawings.

(Overall structure of fertilized egg injector)
FIG. 1 is an explanatory view of a fertilized egg injector to which the present invention is applied. In FIGS. 1 (a), (b) and (c), the fertilized egg injector is inserted into the uterine body of a cow. The state where the nozzle body is advanced to the deep uterine horn and the state where the fertilized egg is injected into the deep uterine horn are shown. FIG. 2 is an explanatory view showing main components of a fertilized egg injector to which the present invention is applied. FIGS. 2 (a), (b), (c), (d), and (e) show guides. A state in which the injection tube is passed through the tube, a state in which the injection tube is pulled out from the guide tube, a state of the nozzle body when the tube is extended from the guide tube, a state of the nozzle body when the injection tube is slightly extended from the guide tube, The state of the nozzle body when the injection tube is drawn into the guide tube is shown.

  As shown in FIG. 1 and FIGS. 2 (a) and 2 (b), a fertilized egg injector 1 of this embodiment is an injector for injecting a fertilized egg into a mammal such as a cow, and generally for insertion into the uterus. The guide tube 2, an injection tube 3 passed through the guide tube 2, and a fluid supply device 8 such as a syringe connected to the proximal end side of the injection tube 3. The guide tube 2 is a metal tube having a flange portion 21 attached to the base end portion, and has rigidity. The injection tube 3 has flexibility at least at the tip, and a nozzle body 4 is connected to the tip of the injection tube 3. The fluid supplier 8 is connected to the proximal end side of the injection tube 3 via a cylindrical connector 6, and a fertilized egg is injected into the injection tube 3 using the cylindrical connector 6. . The fertilized egg may be held by the inside of the cylindrical connector 6 itself. The fertilized egg injector 1 of this embodiment can also be used when injecting sperm for artificial insemination.

  For example, in order to inject a fertilized egg into the uterine body of a cow using the fertilized egg injector 1 configured as described above, first, the injection tube 3 is placed in the guide tube 2 as shown in FIG. In the retracted state, the guide tube 2 is inserted into the uterine body A1 from the vaginal opening. At this time, one hand covered with a thin cover (not shown) made of vinyl or the like is inserted into the rectum B1 from the anus, and the cervical canal A12 is grasped from the rectum B1 to guide the guide tube 2 into the uterine body A1.

  Next, as shown in FIG. 1 (b), the injection tube 3 is pushed out from the tip of the guide tube 2 so that the nozzle body 4 reaches the deep part of the uterine horn A11. And as shown in FIG.1 (c), the piston 81 of the fluid supply device 8 is pressed. Here, a liquid material containing a fertilized egg is held inside the injection tube 3, and the fluid supplier 8 is filled with a fluid such as air or liquid. For this reason, the fertilized egg held inside the injection tube 3 by the fluid supplied from the fluid supply device 8 is supplied to the nozzle body 4 through the injection tube 3, and the deep part of the uterine horn A11 from the nozzle body 4 Injected into. After that, as shown by the arrow P, the fertilized egg injector 1 is pulled out from the vaginal opening. At that time, the injection tube 3 is in a state where the distal end portion is pulled out from the distal end of the guide tube 2 or is pulled into the guide tube 2.

  In the injection operation, for example, the guide tube 2 is placed in the uterine body A1 with a thin cover (not shown) made of vinyl or the like placed on at least a portion of the fertilized egg injector 1 inserted into the uterine body A1. Then, the tip of the fertilized egg injector 1 is protruded from the cover, and then the injection tube 3 is extended from the tip of the guide tube 2 so that the nozzle body 4 reaches the deep part of the uterine horn A11.

(Detailed configuration of fertilized egg injector 1)
As shown in FIG. 2 (b), the injection tube 3 has a flexible tube 30 extending over the entire length of the injection tube 3, and the nozzle body 4 is connected to the tip of the tube 30. Yes. The tube 30 is made of a flexible resin such as silicone resin or vinyl chloride resin. In this embodiment, the tube 30 made of silicone resin is used because the flexibility of the tube 30 is preferably not easily affected by the environmental temperature when the fertilized egg injector 1 is used. In addition, the rigidity of the injection tube 3 may be increased by covering a reinforcing sleeve on the outside of a portion of the tube 30 that is spaced from the nozzle body 4 toward the base end side.

  A cylindrical connector 6 is connected to the proximal end portion of the injection tube 3. Here, the length dimension of the injection tube 3 is larger than the length dimension of the guide tube 2. Therefore, when the rear end portion (tubular connector 6) of the injection tube 3 is pressed forward until the rear end portion (tubular connector 6) of the injection tube 3 contacts the flange portion 21 of the guide tube 2, the injection tube 3 Will protrude from the tip of the guide tube 2.

  On the other hand, when the injection tube 3 is pulled toward the proximal end side, a stopper portion 45 of the nozzle body 4 to be described later is brought into contact with the distal end portion of the guide tube 2 as shown in FIGS. The injection tube 3 is drawn into the guide tube 2 until it comes into contact.

(Configuration of nozzle body 4)
FIG. 3 is an explanatory view of a nozzle body used in a fertilized egg injector to which the present invention is applied. FIGS. 3A and 3B show a side surface of the nozzle body and a cross section of the nozzle body 4. ing.

  As shown in FIGS. 2 (c) to 2 (e) and FIGS. 3 (a) and 3 (b), the nozzle body 4 includes a connecting cylinder part 42 connected to the tip of the injection tube 3, and a connecting cylinder part. A barrel portion 44 having a diameter larger than 42 and a tip portion 43 formed in a spherical shape on the distal end side of the barrel portion 44 are provided, and a nozzle hole 48 is opened on a side surface of the barrel portion 44. In this embodiment, the outer diameter dimension of the base end side of the connecting cylinder part 42 is 0.9 mm, the outer diameter dimension of the body part 44 is 2.92 mm, and the inner diameter dimension of the nozzle hole 48 is 0.8 mm to 1 mm. 0.0 mm.

  In this embodiment, at the connecting portion between the nozzle body 4 and the injection tube 3, the connecting cylinder portion 42 has a structure in which the inside of the distal end portion of the injection tube 3 is fitted. A convex portion 41 a having a triangular cross section that prevents the injection tube 3 from coming off is formed on the outer peripheral surface of the connecting tube portion 41, and the convex portion 41 a bites into the inner surface of the injection tube 3. Further, a taper is formed on the outer peripheral surface of the connecting cylinder portion 42 so that the base end side (injection tube 3 side) of the convex portion 41 a is easy to fit the connecting cylinder portion 42 inside the injection tube 3.

  Here, a stopper portion 45 is formed on the outer periphery of the distal end portion 43 of the nozzle body 4, and the outer diameter of the stopper portion 45 is larger than the inner diameter of the guide tube 2 shown in FIG. Therefore, when the injection tube 3 is pulled toward the proximal end side, the stopper portion 45 of the nozzle body 4 functions as a stopper that contacts the distal end portion of the guide tube 2. In this embodiment, the outer diameter of the stopper portion 45 is about 3 mm.

  In this embodiment, the stopper portion 45 is formed by a portion whose outer diameter dimension is continuously increased from the proximal end side toward the distal end side. Further, the outer diameter of the distal end portion of the injection tube 3 (the distal end portion of the tube 30) is outside the barrel portion 44 in a state where the connecting cylinder portion 42 is fitted to the distal end portion of the injection tube 3 (the distal end portion of the tube 30). It is approximately equal to the diameter. For this reason, a step portion facing the injection tube 3 having an outer diameter larger than the outer diameter of the injection tube 3 is not formed from the injection tube 3 to the stopper portion 45 of the nozzle body 4.

  Inside the nozzle body 4 configured in this way, there are a first flow path 46 extending linearly from the base end side to a midway position on the front end side, and the tip end of the nozzle body 4 from the tip end portion of the first flow path 46. A second flow path 47 is formed that extends obliquely linearly toward the side and opens as a nozzle hole 48 on the side surface of the nozzle body 4. For this reason, the nozzle hole 48 is opened obliquely forward. In this embodiment, the first flow path 46 is formed coaxially from the connecting cylinder part 42 to the body part 44 in the connecting cylinder part 42 and the body part 44, and the first flow path 46 is connected to the body part 44. The nozzle hole 48 is opened on the outer peripheral surface.

  Both the first flow path 46 and the second flow path 47 have an inner diameter of 0.8 mm to 1.0 mm, and the angle formed by the first flow path 46 and the second flow path 47 is 110 ° to 130 °. is there. In the present embodiment, only one second flow path 47 is formed, and the nozzle hole 48 is formed only in one place.

(Main effects of this form)
As described above, in the fertilized egg injector 1 of the present embodiment, the guide tube 2 is inserted into the uterine body from the vaginal opening while the injection tube 3 is pulled into the guide tube 2, and then the injection tube 3 is connected to the guide tube 2. The fertilized egg and sperm are supplied to the nozzle body 4 through the injection tube 3 by the fluid supply device 8 and discharged from the nozzle body 4 in a state where the nozzle body 4 reaches the deep part of the uterine body. Next, the fertilized egg injector 1 is carefully pulled out from the vaginal opening with the tip of the injection tube 3 drawn out from the tip of the guide tube 2 or with the injection tube 3 drawn into the guide tube 2.

  During the operation, the second flow path 47 extends obliquely inside the nozzle body 4 and opens as a nozzle hole 48 on the side surface of the nozzle body 4, and the nozzle hole 48 faces obliquely forward. Therefore, when the fertilized egg is discharged from the nozzle body 4, the fertilized egg is on the front side (tip side) from the position where the second flow path 47 is opened (position of the nozzle hole 48), and further from the nozzle body 4. Released to the front side (tip side). Therefore, it is difficult for the fertilized egg to flow backward to the nozzle body 4. Further, when the injection tube 3 is pulled to the proximal end side, the fertilized egg is caught by the opening edge of the nozzle body 4 or the second flow path 47 (opening edge of the nozzle hole 48) and scraped out from the uterus. This can be suppressed. Therefore, the conception rate can be improved.

  Further, in the nozzle body 4, only one second flow path 47 is formed, and the nozzle hole 48 is formed only in one place. For this reason, it can suppress more reliably that a fertilized egg is caught on the opening edge of the 2nd flow path 47 (opening edge of the nozzle hole 48), and is scraped out from the inside of a uterus.

  Further, since the outer diameter of the stopper portion 45 is continuously increased from the proximal end side to the distal end side, the stopper portion 45 is connected to the stopper portion 45 from the connecting portion between the injection tube 3 and the connecting cylinder portion 42 of the nozzle body 4. The portion leading to does not have a step portion having an outer diameter larger than the outer diameter of the injection tube 3. Therefore, when the injection tube 3 is pulled to the proximal end side, the uterine inner wall is not damaged by the step. Moreover, after injecting a fertilized egg, when the injection tube 3 is pulled to the proximal end side, it is possible to suppress the fertilized egg from being scraped out of the uterus by a step.

[Other embodiments]
In the above embodiment, the description has focused on injecting a fertilized egg. However, the fertilized egg injector 1 may be used for injecting a sperm for artificial insemination.

  In the above embodiment, fertilized eggs and sperm injection into cows are exemplified, but the fertilized egg injector 1 may be used for fertilized eggs and sperm injection into mammals other than cows.

1 ..fertilized egg injector 2 .. guide tube 3 ..injection tube 4 ..nozzle body 30 ..tube 45 ..stopper portion 46..first flow path 47..second flow path 48..nozzle hole

Claims (3)

A fertilized egg injector for injecting a fertilized egg into the uterine body,
An injection tube provided with a flow path to which the fertilized egg is supplied, and a nozzle body connected to the tip of the injection tube,
The nozzle body extends from the base end side connected to the injection tube to a middle position on the tip end side, and extends obliquely from the first flow path toward the tip end side of the nozzle body. And a second flow path opening on the side surface of the nozzle body.   The fertilized egg injector according to claim 1, wherein the nozzle body includes only one second flow path. A guide tube through which the injection tube passes;
The nozzle body includes a stopper portion in which the outer diameter dimension is continuously increased from the proximal end side to the distal end side in the nozzle body, and the outer diameter dimension is larger than the inner diameter dimension of the guide tube. The fertilized egg injector according to claim 1 or 2.

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