JP2014057723A - Container with port and method for manufacturing the same - Google Patents

Abstract

[PROBLEMS] To accommodate a port seal due to impact of liquid contents, etc. even when the sheet is hard and difficult to weld a port, or when the sealability of sealant is poor and the sheet is strongly sealed and the sheet becomes thin. Provided is a container with a port having a port welding structure in which pinholes in a three-part welded portion facing a chamber are unlikely to occur.
A container with a port having a port for communicating inside and outside of a storage chamber formed in a resin bag, wherein the seat of the port mounting portion is left as an opening in a part of the periphery of the storage chamber A port seal in which a welding base portion of the port is inserted between the port seal and liquid-tight welding leaving an unwelded portion at the tip, and the accommodation chamber of the port seal inside the edge of the port seal on the accommodation chamber side A container with a port or the like having a shoulder seal in which only the sheets on both sides of the port, which are continuous or close to the side edge, are welded at the port, leaving an unwelded portion.
[Selection] Figure 1

Description

  The present invention relates to a container with a port and a method for manufacturing the same, and more particularly to a technique for preventing pinholes at the port of a bag due to impact of a content liquid or the like.

In general, various kinds of liquid drugs are stored and distributed using resin containers. As the resin used for these, polyethylene (PE), polypropylene (PP) and the like are common.
When a certain kind of medicine is accommodated in a container using PE, PP, etc., the component of the medicine may be adsorbed on the inner wall of the container, or the composition of the medicine may change due to the permeation of the medicine component or moisture. is there. In addition, oxygen or carbon dioxide gas may enter from the outside, and the component composition of the drug may change.
The resin layer and the adhesive layer often contain low molecular weight components such as unreacted monomers and various additives. The low molecular weight component contained in the layer constituting the container permeates through the innermost layer of the container or the low molecular weight component contained in the innermost layer of the container elutes into the content liquid, and these react with various components in the content liquid. There is also a case.

Against this background, in recent years, barrier layers made of resins such as polyethylene terephthalate (PET), polyacrylonitrile (PAN), ethylene-vinyl alcohol copolymer (EVOH), and cyclic polyolefin resin (COP resin) have become the most popular. Containers used for inner and intermediate layers have been proposed.
On the other hand, for example, in a container with a port for storing a chemical solution, a welding port is not a boat shape but a cylindrical port is often used so that a total amount can be instilled by its own weight. However, the cylindrical weld base has a disadvantage that it is difficult to weld the port because the port weld has a three-dimensional shape as compared with the boat-shaped weld base. In particular, the layer made of these resins is harder than the layer made of PE or PP, so that it has high rigidity when formed into a multilayer sheet and is difficult to weld the port. Therefore, when a port is welded to a bag made of these resins, it is necessary to weld the bag at a high temperature or high pressure.

Moreover, the welding of the ports requires heating from both sides of the front and back sheets. However, the front and back sheets in contact with the port are blocked by the port and are not heated from the port side. On the other hand, since the welding of the sheets that do not contact the port is not blocked by the port, the sheet is heated from both sides by a high-temperature seal bar. Therefore, if the welding strength between the port and the front and back sheets is appropriately controlled, the welded portion between the sheets tends to be excessively heated, and the sheet becomes thin and pinholes are easily generated.
In addition, since the front and back sheets that are welded in a cylindrical shape along the outer peripheral surface of the port are welded to each other in a plane, the sheets are welded to each other in a plane. Suppress and weld. Due to this distortion, the port seal is likely to be hot peeled off while the seal mold is separated from the welded part and the cooling mold suppresses the welded part. When the welded portion is cooled in a state where partial hot delamination has occurred, although the port seal is formed, the weld strength between the sheets at the port tends to be low.

  Further, the port seal has a three-part welded portion where the front and back sheets and the port are welded together. The port opens in a substantially cylindrical shape in the accommodation chamber, and the edge of the three-part welded portion also faces the accommodation chamber. Therefore, the sheet near the three-part welded portion facing the storage chamber forms a cylindrical hollow portion in which the port extends toward the inside of the storage chamber. On the other hand, since the welded portion between the sheets on the periphery of the storage chamber that does not include the port is flat, the strain that the entire storage chamber is flattened concentrates on the three-part welded portion that faces the storage chamber.

  And since the sheet in the vicinity of the three-part welded portion facing the storage chamber is a cylindrical hollow portion facing the inside of the storage chamber, the packaging body filled with the content liquid is stored in a container with a port. The load or the impact of the inner solution at the time of dropping or transportation is easily transmitted directly to the sheet near the three-part welded portion. For this reason, it is easy to receive the effect | action of the force of the direction in which the welding part of the sheet | seat at the time of the port of the three-part welding part which faces a storage chamber peels. And when the action | operation of the force of the direction which the three-part welding part which faces a storage chamber peels is received, the sheet | seat with a larger deterioration will tear and a pinhole will generate | occur | produce.

Regarding the welding of a port, in Japanese Patent Application Laid-Open No. 2006-204610 (Patent Document 1), in order to prevent the sheet portion near the outer peripheral surface of the port or the like from repelling the pressing of the mold at the time of welding, the vicinity of the outer peripheral surface of the port The soft bag is pressed from the both sides of the soft bag with the pressing means adjacent to the seal mold, and the sheets constituting the port mounting portion are brought close to or in contact with each other. A method for manufacturing a container with a port has been proposed in which a port is welded to a soft bag in the vicinity of the port mounting portion.
According to this method, the sheet located on the outer peripheral surface of the port or on both sides thereof is unlikely to become thin, so that the sheet is hardly broken (pinhole).

Further, in JP 2011-50559 A (Patent Document 2), a weak sealing step for weakly sealing the end of a port inserted into the bag, and a peripheral side of the bag that is close to the weakly sealed portion. There has been proposed a method for manufacturing a container with a port including a strong sealing step in which a portion is thermally welded to a bag at a temperature higher than a weak seal.
According to this method, since the weak seal portion is formed over a long period of time at a lower seal temperature and pressure than the strong seal portion, it is difficult to reduce the thickness. In addition, since the weak seal portion keeps the sheet in close contact with the port for a longer time compared to the pressing means of Patent Document 1, it is said that the sheet is less likely to be broken (pinhole) than the proposal of Patent Document 1. The

JP 2006-204610 A JP 2011-50559 A

The method of Patent Document 1 prevents the sheet from being torn by reducing the thickness of the sheet by suppressing the sheet portion near the outer peripheral surface such as the port from repelling the pressing of the mold during welding.
However, in the proposal of Patent Document 1, although the tearing of the sheet due to the thinning of the sheet on the outer peripheral surface of the port due to heat at the time of welding is improved, the port seal accommodating chamber when the content liquid is filled No consideration is given to the pinhole of the sheet at the port of the three-part welded part facing the surface.
Therefore, the method of Patent Document 1 cannot reliably protect the three-part welded portion facing the storage chamber side of the port seal due to the load or impact of the internal solution.

In the method of Patent Document 2, a weak seal portion is formed instead of the compression means of Patent Document 1 in order to compress the sheet. Since this weak seal part exists inside the bag rather than the strong seal part, in light of the gist of the present invention, the three-part weld part facing the port seal accommodation chamber due to the load or impact of the internal solution is protected. Looks like.
However, the method of Patent Document 2 also prevents the tearing of the sheet due to the thinning of the sheet on the outer peripheral surface of the port at the time of welding, as in the method of Patent Document 1. Therefore, the weak seal portion is formed across the port. Therefore, in order to prevent the sheet on the outer peripheral surface of the port from being thinned, the seal is weak.
Therefore, the weak seal part is formed with a welding strength that does not peel off due to the weight of the liquid at the time of hanging the container. Estimated to peel easily. That is, the weak seal portion needs to be sealed more strongly in order to prevent peeling and pinholes of the three-part welded portion facing the storage chamber side of the strong seal portion due to the load or impact of the internal solution. However, since the port is thinned, it cannot be strongly sealed. Therefore, it is considered that this weak seal portion cannot reliably protect the three-part welded portion.

  The present invention has been made in view of the above circumstances, and even when the sheet is hard and the port is difficult to weld or when the sealability of the sealant is poor, even if the sheet is thinned and the sheet is thinned, It is an object of the present invention to provide a container with a port having a welding structure for a port that protects a three-part welded portion facing the storage chamber from the impact of the content liquid and the like, and a method for manufacturing the container with a port.

In order to solve the above problems, the inventors of the present invention have intensively studied the welded structure of the port in which pinholes due to the load or impact of the internal solution are unlikely to occur, and as a result, attacked by the load or impact of the internal solution. When receiving the force acting in the direction that peels off the three-part welded part (port seal port and the two front and back sheets welded) facing the storage chamber, a pinhole is generated. I found out.
The inventors of the present invention, for example, when the sheet is hard and it is difficult to weld the port or when the sealability of the sealant is poor, even if the sheet is thinned and the sheet becomes thin, due to the load or impact of the inner solution, etc. In order to prevent sheet tearing (pinhole), the present invention was completed with the idea of mitigating the load and impact of the internal solution reaching the three-part welded portion facing the port seal accommodation chamber. .

The present invention based on such a unique technical idea provides the following container with a port.
[1] A container with a port having a port for communicating inside and outside of a storage chamber formed in a resin bag,
A port seal in which a welding base portion of the port is inserted between the seats of the port mounting portion left as an opening in a part of the peripheral edge of the storage chamber, and a non-welded portion is left at the tip, and the port seal is liquid-tightly welded,
Inside the edge of the port seal on the side of the storage chamber, only the sheets on both sides of the port that are continuous or close to the edge of the port seal on the side of the storage chamber are not welded at the time of the port. A container with a port, characterized by having a shoulder seal welded.
[2] The container with a port according to [1], wherein a distance of the shoulder seal entering the storage chamber is equal to or longer than a length of an unwelded portion at a tip of the weld base.
[3] The container with a port according to [1] or [2], wherein an edge of the shoulder seal on the accommodation chamber side is welded while being inclined toward the welding base of the port.
[4] The sheet of the bag is used as a water vapor permeation preventing ability for preventing the permeation of water vapor, a gas permeation preventing ability, a low molecular weight component permeation preventing ability, and a resin constituting the permeation or adsorption of the active ingredient of the inner solution or itself. The functional layer having at least one preventive ability selected from the group consisting of anti-altering ability that prevents alteration of the content liquid due to elution of the contained low molecular weight component, according to any one of [1] to [3] Container with port.
[5] The sheet according to any one of [1] to [3], wherein the bag sheet includes a polyethylene terephthalate layer, a polyacrylonitrile layer, an ethylene-vinyl alcohol copolymer layer, or a layer mainly composed of a cyclic polyolefin resin. Container with port.
[6] The container with a port according to any one of [1] to [3], wherein the sealant of the bag has a cyclic polyolefin resin as a main component.
[7] The container with a port according to [6], wherein at least the innermost layer of the port has a cyclic polyolefin resin as a main component.

Moreover, this invention provides the manufacturing method of the following containers with a port.
[8] A method for manufacturing a container with a port having a port for communicating the inside and outside of a storage chamber formed in a resin bag,
A step of inserting a welding base portion of the port between sheets of a port attachment portion left as an opening portion at a part of the peripheral edge of the storage chamber, and forming a port seal in which liquid welding is performed leaving an unwelded portion at the tip. When,
Inside the edge of the port seal on the side of the storage chamber, forming a shoulder seal that welds only the sheets on both sides of the port that are continuous or close to the edge of the port seal on the side of the storage chamber; In this order. A method for manufacturing a container with a port.
[9] The method for manufacturing a container with a port according to [8], wherein the shoulder seal is formed by welding the sheets together including all of the port seal except for the port at the end of the accommodation chamber.
[10] The container with a port according to [8] or [9], wherein the port seal is formed while leaving unwelded portions at both ends, and the unwelded portions at both ends of the port seal are liquid-tightly welded with the shoulder seals. Manufacturing method.
[11] Any one of [8] to [10], wherein the shoulder seal is formed such that an edge of the shoulder seal on the accommodation chamber side is 1 mm or more inside from an edge of the port seal on the accommodation chamber side. The manufacturing method of the container with a port of description.

According to the container with a port described in [1], the shoulder seal does not weld the sheet in contact with the outer surface of the port, so even if it is strongly welded, the sheet is not damaged at the time of welding.
The portion where the port seal in the vicinity of the three-part welded portion faces the accommodation chamber due to the shoulder seal is a narrow portion viewed from the gap between the port and the shoulder seal. These portions of the sheet and the front end of the port weld base and the sheet in contact with it become a continuous unwelded portion. However, the shoulder seal and the port seals on both sides of the port cause the port weld base end of the unwelded portion to be in close contact with the sheet and the sheets, making it difficult for the content liquid to enter the unwelded portion. Thereby, the impact of the inner solution is not easily transmitted to the three-part welded portion, so that the impact of the content liquid is mitigated and the three-part welded portion is protected.
Moreover, since the continuous unwelded portion is difficult for the content liquid to enter, it is possible to obtain the same effect as reducing the amount that the tip of the port enters the storage chamber substantially, and reducing the residual liquid when discharging the content liquid. be able to.

According to the container with a port as described in [2], in addition to the effect of the container with a port as described in [1], the shoulder seal enters the inside of the storage chamber. Therefore, the remaining liquid can be extremely reduced when the content liquid is discharged.
According to the container with a port described in [3], in addition to the effect of the container with a port described in [1] or [2], when the content liquid is discharged by hanging the container with a port, Therefore, the remaining liquid can be extremely reduced.
According to the container with a port described in [4], in addition to the effects of the container with a port described in [1] to [3], the invasion and dissipation of a substance that may alter the inner solution is prevented. Can do.
According to the container with a port described in [5], in addition to the effects of the container with a port described in [1] to [3], the invasion and dissipation of a substance that may change the inner solution is prevented. Can do.
According to the container with a port described in [6], the effects of the container with a port described in [1] to [3] can be more effectively exhibited.
According to the container with a port described in [7], the effect of the container with a port described in [6] can be more effectively exhibited. And when a container with a port using hard COP resin is subjected to an impact on the port due to a drop or the like, the three-part welded portion facing the storage chamber tends to be a pinhole, coupled with the impact of the liquid content. Can be effectively prevented.

  According to the method for manufacturing a container with a port described in [8], not only in the case of a normal polyolefin sealant having excellent sealing characteristics, but particularly in the case where the sheet is hard and the port is difficult to weld or the sealability of the sealant is poor. Even if the three-part welded portion facing the storage chamber is strongly welded and the sheet is thinned, it has a port-welded structure that can prevent peeling of the three-part welded portion and pinholes due to impact of the internal solution or the like [ The container with a port according to 1] to [7] can be easily produced.

According to the method for manufacturing a container with a port described in [9], in addition to the effect of the method for manufacturing a container with a port described in [8], the shoulder seal is connected to the edge of the port seal at the end of the container on the container side. Since it is welded including everything except for it, there is no possibility that a pinhole will occur at the edge of the port seal that is not protected by the shoulder seal.
According to the method for manufacturing a container with a port described in [10], in addition to the effect of the method for manufacturing a container with a port described in [8] or [9], the case where the sheet is hard and the port is difficult to weld, When the sealability is inferior, the welding area between the sheets of the port seal can be reduced to facilitate the control per die. Thereby, since the welding part of the sheet | seat of a port seal is formed appropriately, a pinhole is hard to generate | occur | produce.
According to the method for manufacturing a container with a port according to [11], the effects of the method for manufacturing a container with a port according to [8] to [10] can be more reliably exhibited.

It is a top view which shows one example of a container with a port of this invention. A is an enlarged view of the vicinity of the three-part welded part in FIG. 1, and B is an enlarged view showing another example of the vicinity of the three-part welded part. It is a top view which shows an example of the bag of a container with a port. It is sectional drawing which shows an example of the port of a container with a port, and the welding aspect of a cylinder part. It is sectional drawing which shows an example of the plug part and cylindrical part of the port of FIG. It is sectional drawing which shows another example of the plug part and cylindrical part of a port.

Hereinafter, the present invention will be described in more detail with reference to the drawings.
FIG. 1 is a plan view showing an embodiment of the container with a port of the present invention.
In the container 1 with a port of the present invention, one or more ports 3 are welded to the bag 2 shown in FIG. 3 in the manner shown in FIG. The port 3 is mainly used for discharging the internal solution, but can also be used as a filling port for the internal solution.
When the port 3 does not serve as a filling port for the internal solution, the port 3 formed by welding the plug body portion 4 and the cylindrical body portion 5 is welded to form the ported container 1 of FIG. When the port 3 also serves as the filling port for the internal solution, only the cylindrical part 5 is welded to the bag 2 as the port 3, and the plug part 4 is welded after filling the internal solution. Assuming this case, in this specification, the port 3 may mean the cylindrical portion 5.

FIG. 3 is a plan view showing the bag 2 of the container 1 with a port according to this embodiment.
The bag 2 is a bag-like container in which the periphery of a single-layer or multilayer sheet or tube is welded, or a single-layer or multilayer blow-molded container.
The bag-like bag 2 of the present embodiment forms the outer peripheral seal 15 by welding the periphery of the front and back sheets 12 and 12. When the outer peripheral seal 15 is formed, an unwelded opening is left as a port attachment portion 17 in a part of the outer peripheral seal 15 that defines the accommodation chamber 16. In addition, when using a tube, the welding of the both sides of the outer periphery seal | sticker 15 or all the welding of the outer periphery seal | sticker 15 can be abbreviate | omitted.
In the bag 2, a hole 18 in which the container 1 with a port can be hung, or a hanging portion 18 made of a slit or the like obtained by cutting a part of the sheets 12, 12 of the bag 2 is provided at a position facing the port 3. The hanging part 18 is preferably used when the internal solution is instilled.

When the bag 2 is a bag-shaped multilayer container, the multilayer sheet is laminated by coextrusion molding such as multilayer inflation molding, multilayer T-die casting, multilayer blow molding, or extrusion lamination or adhesive that directly laminates molten resin. A laminate such as a dry laminate using can be used.
When the bag 2 is a blow molded container, multilayer blow molding is suitably employed. In the multilayer blow molding, a COP resin or a polyolefin resin (PO resin), and if necessary, an adhesive resin or other resin are melt-extruded and blow molded using a multilayer extruder. In blow molding, the preform may be blow molded once after being preformed, or may be formed into a tubular multilayer parison inside the multilayer parison molding die and may be directly blow molded.
In the blow molded product bag 2, when the bag 2 is molded, the port mounting portion 17 is left as an opening in a part of the peripheral edge of the storage chamber 16.

The volume of the container 1 with a port varies depending on the purpose of use of the liquid to be stored, but is usually about 30 to 5,000 ml. More generally, it is about 100 to 3,000 ml.
The thickness of the sheet 12 forming the bag 2 is appropriately selected according to the layer structure and flexibility of the resin used, mechanical strength, water vapor permeability, heat resistance, and the like. Usually, the thickness of the sheet 12 is selected from 70 to 500 μm, and 200 to 300 μm is frequently used.
In the present specification, a film and a sheet may be referred to as a sheet without distinction. Moreover, the single layer or multilayer sheet which comprises the bag-shaped container and the bag 2 of a blow molded product may be named generically. Furthermore, in this specification, the “main component” means a component of 50% by mass or more.

Examples of the resin that forms the sheet 12 of the bag 2 include polyethylene (PE), polypropylene (PP), polybutadiene, polyolefins such as ethylene-vinyl acetate copolymer (EVA), olefin elastomers, styrene elastomers, and the like. Examples include various thermoplastic elastomers, resins blended with these, and polymers alloyed resins.
When the container 1 with a port is used for storing retort food or medical liquid, the bag 2 is deformed, broken or broken by high-temperature sterilization at 100 ° C or higher, preferably 110 ° C or higher, more preferably 121 ° C or higher. It is preferable that no whitening occurs.
When the container 1 with a port is used for the sheet | seat 12 of the medical bag 2, it is preferable that the bag 2 has high transparency, moderate softness | flexibility, and water resistance. If the sheet 12 of the bag 2 is transparent, the inner solution is highly visible, and it is easy to check the alteration of the inner solution. Examples of such resins include COP resins and PO resins such as PP and PE.

The sheet 12 of the bag 2 is permeable to water vapor, permeable to gases such as oxygen and carbon dioxide, and permeable to low molecular weight components such as unreacted monomers and various additives contained in the resin layer and adhesive layer constituting the sheet 12. In addition, a functional layer that prevents at least one of permeation and adsorption of the active ingredient in the inner solution and elution of the low molecular weight component contained in the resin can be laminated.
Since these functional layers often have high rigidity, and in many cases, dry lamination is adopted for lamination to increase the rigidity of the multilayer sheet, the present invention is preferably applied.
As a functional layer for preventing water vapor permeation (water vapor barrier), fluorine resins such as polytetrafluoroethylene (PTFE) and ethylene-tetrafluoroethylene copolymer (ETFE), cyclic polyolefin resins (COP resins), Examples thereof include resin layers and films such as polyester and nylon films on which alumina or silica is deposited.

  Examples of the functional layer that prevents permeation of gas such as oxygen and carbon dioxide (gas barrier) include polyamides such as 6-nylon and MXD nylon, polyols such as polyvinyl alcohol (PVOH) and ethylene vinyl alcohol copolymer (EVOH), Polyester resins such as polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyester elastomers, the above fluorine resins, PVOH coating film, polyacrylonitrile (PAN) and its coating film, polyvinylidene chloride (PVDC) and Examples of the coating film include resin layers and films such as polyester and nylon films deposited with alumina or silica. Of these, the resin layers of PET, PBT, PAN, and EVOH have weldability, and can be laminated as the sealant 13. In particular, PET, PAN and EVOH are preferable as the sealant 13 because of their high welding strength.

As the functional layer for preventing the permeation of low molecular weight components such as unreacted monomers and various additives contained in the resin layer and the adhesive layer constituting the sheet 12 and the permeation and adsorption of the active components of the inner solution, A resin layer or a film such as polyester resin, the above fluorine resin, EVOH, PAN, COP resin, polyester or nylon film on which alumina or silica is deposited can be laminated. Since the polyester resin, EVOH, PAN and COP resin have weldability, they can be laminated as the sealant 13.
Examples of the resin capable of forming a layer free from composition change of the content liquid and content liquid contamination due to elution of low molecular weight components contained in the resin constituting itself include the above-described polyester resins and COP resins. Since the COP resin has weldability, it can be laminated as the sealant 13.

The container 1 with a port according to the present embodiment is used for containing a medical liquid. Therefore, as the sealant 13 (welding layer) of the bag 2, there is no adsorption of the active ingredient of the content liquid, no composition change of the content liquid due to elution of the low molecular weight component and no content liquid contamination, and good weldability is exhibited. Moreover, a functional layer having heat resistance that can withstand high temperature sterilization is preferable.
As a resin of such a functional sealant 13, a COP resin is most preferable. Similar functionality can be expected using polyester resins such as PET and polyester elastomer, PAN, EVOH, etc., but the effect is inferior to that of COP resins.

Therefore, in the bag 2 of this embodiment, a layer (COP resin layer) made of a resin mainly composed of a COP resin is laminated as a functional layer and a sealant.
The sealant 13 (COP sealant) of the COP resin layer is 15 to 150 μm, preferably 25 to 100 μm. If the thickness of the sealant 13 is less than this range, the welding strength with the port 3 may not be sufficient. In addition, when the port 3 is welded, the sealant 13 may be thinned by heating and pressurization, and the welding strength may be reduced, or liquid leakage may occur due to pinholes (sheet tearing). The thickness of the sealant 13 may exceed this range, but if the thickness is increased, the flexibility of the container may be inferior. Further, it is not preferable in terms of cost.

As the COP resin of the COP sealant 13, a COP resin having a glass transition temperature (Tg) of about 70 to 170 ° C. is adopted.
The COP resin of the sealant 13 may be one type of COP resin or a blend of several types of COP resins. In any case, it is preferable that Tg is within the above range.
The proportion of the COP resin in the sealant 13 is 50% by mass or more, preferably 70% by mass or more, and more preferably 80% by mass or more. If this ratio is less than 50% by mass or the Tg of the COP resin is less than 70 ° C., the bag 2 may be deformed or broken during high temperature sterilization at 110 ° C. or higher.

The COP sealant 13 is preferably blended with a COP resin having a Tg of less than 100 ° C. from the viewpoint of improving heat sealability. The proportion of the COP resin having a low Tg in the entire resin is 50% by mass or less, preferably 30% by mass or less, and more preferably 20% by mass or less. If this ratio is too high, the sealing property is improved, but sufficient heat resistance is not ensured during high-temperature sterilization, and the container may be deformed.
The difference in glass transition temperature between the COP resin having a low Tg and the COP resin having a high Tg is preferably 20 ° C. or higher.

The COP resin used for the sealant 13 of the bag 2 is obtained by polymerizing a monomer composition containing a cyclic olefin monomer.
Examples of the cyclic olefin monomer include norbornene, norbornadiene, methylnorbornene, dimethylnorbornene, ethylnorbornene, chlorinated norbornene, chloromethylnorbornene, trimethylsilylnorbornene, phenylnorbornene, cyanonorbornene, dicyanonorbornene, methoxycarbonylnorbornene, pyridylnorbornene, nadic anhydride Products, bicyclic cycloolefins such as nadic imides; tricyclocycloolefins such as dicyclopentadiene, dihydrodicyclopentadiene and alkyl, alkenyl, alkylidene, and aryl substituents thereof; dimethanohexahydronaphthalene, dimethanooctahydronaphthalene, Tetracyclic cycloolefins such as alkyl, alkenyl, alkylidene and aryl substituents Pentacyclic cycloolefins such as tricyclopentadiene; and hexacyclic cycloolefins such as hexamethylene cycloheptanone decene and the like. Further, dinorbornene, a compound in which two norbornene rings are bonded by a hydrocarbon chain or an ester group, and a compound containing a norbornene ring such as an alkyl or aryl substituent thereof can be used. These may be used alone or in combination of two or more. When two or more types are used, a resin having various physical properties can be obtained by appropriately combining a monomer having one double bond to be a thermoplastic resin and a monomer having a plurality of double bonds to be a thermosetting resin. can do. Moreover, compared with the case where a single monomer is used, the range in which the monomer can be handled as a liquid may be expanded due to the freezing point depression, which is preferable.
Among these, examples of the cyclic olefin monomer suitably used for the sealant 13 of the bag 2 include norbornene monomers such as dicyclopentadiene, norbornene, and tetracyclododecene. In addition, the norbornene system means that a norbornene skeleton is included in the molecular skeleton.

From the viewpoint of reducing the interaction with a trace amount of active ingredients and the like in the content liquid and further improving the water vapor barrier property, it is preferable to use a cyclic olefin monomer that contains as little polar groups as possible. However, depending on the content liquid, a monomer having a polar group may be used in combination.
Examples of the monomer having a polar group include substitution products and derivatives in which a halogen group such as chlorine or bromine or an ester group is introduced into the norbornene-based monomer described above. The proportion of the monomers having these polar groups in the whole monomer is preferably 30% by mass or less. When it exceeds 30 mass%, the water absorption of the polymer obtained will become large.

As the monomer of the COP resin, other monomers can be used in combination with the cyclic olefin monomer.
Examples of other monomers include α-olefins having 2 or more carbon atoms. Specifically, ethylene, propylene, 1-butene, 1-pentene, 1-hexene, 3-methyl-1-butene, 3-methyl-1-pentene, 3-ethyl-1-pentene, 4-methyl-1 -Pentene, 4-methyl-1-hexene, 4,4-dimethyl-1-hexene, 4,4-dimethyl-1-pentene, 4-ethyl-1-hexene, 3-ethyl-1-hexene, 1-octene 1-decene, 1-dodecene, 1-tetradecene, 1-hexadecene, 1-octadecene, 1-eicocene and the like. These can be used alone or in combination. Of these, ethylene or propylene is preferable, and ethylene is particularly preferable.

The compounding ratio when the cyclic olefin monomer and the other monomer are used in combination is usually 98/2 to 30/70, preferably 95/5 to 40/60, as the mass ratio of the cyclic olefin monomer / other monomer. . If the amount of the cyclic olefin monomer is more than this range, sufficient weldability may not be obtained. On the other hand, if the amount of the cyclic olefin monomer is less than this range, the non-adsorbability of the active ingredient in the content liquid may be impaired.
In addition, as a polymerization method and a polymerization mechanism when a plurality of types of monomers are used in combination, copolymerization may be performed by mixing at the time of monomer, or block polymerization may be performed after mixing to some extent. Further, it may be ring-opening polymerization or addition polymerization.

The COP resin of the sealant 13 of the bag 2 is a resin obtained by polymerizing a monomer composition containing a cyclic olefin monomer or a derivative thereof. The derivative in this case is a hydrogenated product of a resin obtained by polymerizing a monomer composition containing a cyclic olefin monomer.
The COP resin of the sealant 13 of the bag 2 is preferably a combination of one or more of hydrogenated polynorbornene resins obtained by polymerizing one or more norbornene monomers.

These COP resins have good heat-seal properties, and infusions, drug solutions, X-ray contrast agents, hormone agents, radiopharmaceuticals, cardiovascular agents, digestive system preparations, protein amino preparations, cardiovascular system preparations Because it is difficult to adsorb active ingredients such as enzyme preparations, metabolic drugs, antibiotics, anti-inflammatory drugs, tumor drugs, biological drugs, etc. or vitamins, trace elements, etc., it is used for medical containers It is suitable for the container 1 with a possible port.
As a specific structure of such a COP resin, for example, a structural formula represented by the following general formula (1) or (2) can be shown.

（式中、Ｒ¹，Ｒ²，Ｒ³，Ｒ⁴は互いに同一又は異種の炭素数１〜２０の有機基を示し、また、Ｒ¹とＲ²、及び／又はＲ³とＲ⁴は互いに環を形成していてもよい。ｍ，ｐは０又は１以上の整数を示す。ｌ，ｎは１以上の整数を示す。）

(Wherein R ¹ , R ² , R ³ and R ⁴ represent the same or different organic groups having 1 to 20 carbon atoms, and R ¹ and R ² and / or R ³ and R ⁴ are (The ring may form a ring. M and p represent 0 or an integer of 1 or more. L and n represent an integer of 1 or more.)

  More specifically, examples of the organic group having 1 to 20 carbon atoms include methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, sec-butyl, t-butyl, i-pentyl, t-pentyl, n-hexyl, n-heptyl, n-octyl, t-octyl (1,1-dimethyl-3,3-dimethylbutyl), 2-ethylhexyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, Alkyl groups such as pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, icosyl; cycloalkyl groups such as cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl; 1-methylcyclopentyl, 1-methylcyclohexyl, 1-methyl-4-i-propyl Alkylcycloalkyl groups such as cyclohexyl; Alkenyl groups such as phenyl, propenyl, butenyl, 2-butenyl, hexenyl, cyclohexenyl; aryl groups such as phenyl, naphthyl, methylphenyl, methoxyphenyl, biphenyl, phenoxyphenyl, chlorophenyl, and sulfophenyl An aralkyl group such as a benzyl group, a 2-phenylethyl group (phenethyl group), an α-methylbenzyl group, an α, α-dimethylbenzyl group, and the like, but is not limited thereto. These may be used alone or in combination of two or more.

The Tg of the COP resin can be appropriately adjusted by appropriately selecting the values of l, m, n, and p in the above general formulas (1) and (2) or substituents. The Tg of the COP resin other than the general formulas (1) and (2) can be arbitrarily adjusted by appropriately setting the monomer type to be used, the blending ratio of the monomer type, the monomer sequence, the type of substituent, and the like. it can.
A commercially available product can be used as the COP resin represented by the general formula (1), and for example, ZEONEX and ZEONOR manufactured by ZEON CORPORATION can be suitably used. Commercially available products can be used as the COP resin represented by the general formula (2). For example, Appel manufactured by Mitsui Chemicals, Inc. and TOPAS manufactured by TICONA Inc. can be preferably used.
In addition, various additives such as pigments, dispersants, antioxidants, ultraviolet absorbers, light stabilizers, inorganic fillers and the like can be further added to the sealant layer in the present invention as necessary.

The sheet 12 of the bag 2 has another layer 14 laminated outside the COP sealant 13 in order to impart heat resistance and flexibility. The other layer 14 is preferably a PO resin layer.
As the PO resin layer to be laminated, high-density polyethylene (HDPE), linear low-density polyethylene (LLDPE), medium-density polyethylene (MDPE), polypropylene (PP), and a resin layer mainly composed of these thermoplastic elastomers Can be mentioned. The PO resin layer may be laminated by blending these PO resins, or a plurality of layers may be laminated.
When these PO resin layers are laminated, the bag 2 can be provided with both heat resistance and flexibility.

As a method of laminating the COP resin and the PO resin, extrusion lamination, dry lamination, coextrusion molding or the like is adopted. In the case of laminating by coextrusion molding, these may be directly laminated, or an adhesive resin typified by Mitsui Chemical Co., Ltd. Admer, Mitsubishi Chemical Co., Ltd. Modic, etc. may be used.
As the other (resin) layer 14 laminated instead of the PO resin layer or together with the PO resin layer, a base film such as PET or polyamide may be laminated in order to improve physical strength. The base film is preferably stretched because of its high physical strength, and more preferably biaxially stretched.

Hereinafter, a method for forming the bag 2 and a method for welding the port 3 used in this embodiment will be described in detail.
As shown in FIG. 1, the port-equipped container 1 according to the present embodiment includes a port 3 having a cylindrical welding base in the form shown in FIG. 4 in order to communicate the inside and outside of the storage chamber 16 formed in the resin bag 2. Welded. The bag 2 is formed by overlapping the sealants 13 and 13 of the two sheets 12 and 12 and welding the periphery to form the outer peripheral seal 15. The storage chamber 16 is defined by the outer peripheral seal 15, and as shown in FIG. 3, the bag-like bag 2 having the port attachment portion 17 left as an opening at a part of the periphery is formed.
The opening length of the port mounting portion 17 is preferably narrow as long as the welding base portion of the port 3 does not become difficult to insert. Thereby, a port can be welded appropriately. Therefore, if the shape of the port 3 is the same, the opening of the port mounting portion 17 is narrow when the sheets 12 and 12 are soft, and wide when the sheets 12 are hard.

Since the container 1 with a port of this embodiment is mainly used for storing medical liquids, the container 1 with a port is deformed by high-temperature sterilization at 105 ° C. or higher, preferably 115 ° C. or higher, more preferably 121 ° C. or higher. There should be no bag breakage. Therefore, the COP resin used for the sealant 13 and the port 3 of the bag 2 in this embodiment is preferably a COP resin having a glass transition temperature of 100 ° C. or higher, preferably 110 ° C. or higher.
In addition, in the container 1 with a port of the present embodiment, the sealant 13 and the port 3 mainly composed of COP resin which is hard and brittle and inferior in sealability are used, so that the port seal 19 and the shoulder seals 20 and 20 are formed. The method for manufacturing a container with a port according to the present invention in which the port 3 is welded in stages is preferably used. Therefore, although the welding method of the port 3 is demonstrated based on this, the method of producing the container 1 with a port of this invention is not limited to this.
That is, in the container 1 with a port of the present invention, when the sealant 13 and the port 3 of the bag 2 are made of polyolefin such as PE or PP which is soft and excellent in sealability, the port 3 is welded in one step as usual. Can do. In this case, the seal bar may be formed by integrally forming a part forming the port seal 19 and a part forming the shoulder seals 20 and 20.

The outer peripheral seal 15 may be formed by welding the entire circumference at once with one welding mold, but first, the side seals are formed by welding both sides, and then the upper and lower sides are welded and suspended. It is preferable that the upper seal having the portion where the portion 18 is to be formed and the lower seal having the port mounting portion 17 left as an unwelded opening are formed sequentially or simultaneously. By forming the outer peripheral seal 15 in this way, the pressurization to the welded portion can be precisely controlled, and a good die contact with uniform pressurization can be obtained.
The welding width of the outer peripheral seal 15 is preferably 3 mm or more in order to ensure the welding strength. However, the side seal of the bag 2 preferably has a welding width of 5 mm or less because the capacity of the storage chamber decreases when the welding width is wide.

For the welding of the outer peripheral seal 15, heat welding, ultrasonic welding or high frequency welding can be used. In the present embodiment, since the sealant 13 mainly composed of a hard and brittle COP resin is used, ultrasonic welding causes a part of the sealant 13 to be crushed to generate fine particles, and high-frequency welding takes time for welding. Welding is preferred.
In the case of using heat welding, it is preferable to quickly cool and solidify the welded portion by pressing with a cooling mold immediately after the sheets 12 and 12 are heated and pressurized. The heating and pressurization and cooling of the sheets 12 and 12 may be performed a plurality of times.
The sheets 12 and 12 to be welded may be swelled by vacuum forming or pressure forming.

The hanging portion 18 is formed by punching the upper seal sheets 12 and 12 using a punch, a Thomson blade or the like. Since the sheets 12 and 12 of the outer peripheral seal 15 of the bag 2 are hardened, it is preferable to cut the corners of the bag 2 in a circular arc shape because it prevents the hand and fingers from being damaged and improves the appearance. The hanging portion 18 may be formed when the corner is cut. Alternatively, the hanging part 18 may be formed at the same time when the upper seal is formed. In this case, it is preferable to carry out at the same time as cooling or immediately after cooling.
When using a tube for the bag 2, welding on both sides of the bag 2 may be omitted. When a blow-molded container is used for the bag 2, the bag 2 is molded so that the port attachment portion 17 has an opening at the bottom of the storage chamber 16. Alternatively, after forming the bag 2, the lower portion of the bag 2 may be cut to form the opening. When a blow molded container is used for the bag 2, all welding may be omitted.

When the port 3 is not used as a filling port, the plug part 4 and the cylindrical part 5 of the port 3 are welded in advance. In this case, it is preferable that a part of the outer peripheral seal 15 is left as an opening other than the port mounting portion 17 to form a filling port.
The bag 2 and the port 3 are welded by inserting a welding base portion provided on the cylindrical body portion 5 between the sheets 12 and 12 of the port mounting portion 17, so that the welding base portion of the port 3 and the front and back sheets 12 and 12 and the port 3 are inserted. The front and back sheets 12, 12 are welded together in a liquid-tight manner to form a port seal 19. Note that the welding base portion of the port 3 is a portion to be welded to the sheets 12 and 12 of the cylindrical body portion 5 of the port 3, and usually from an end portion to which the plug body portion 4 of the cylindrical body portion 5 is not welded. It refers to a portion with a predetermined width of about 3 to 30 mm.

When inserting the welding base provided in the cylindrical body 5 between the sheets 12 and 12 of the port mounting portion 17, the port 3 is inserted so that the tip of the port 3 enters the accommodation chamber side 16 rather than the port seal 19. Accordingly, the sheets 12 and 12 pressed against the ridge line at the tip of the port 3 by the heat seal bar at the time of forming the port seal 19 are not broken to form a pinhole.
In addition, although the length which inserts the welding base part tip of the port 3 in the storage chamber 16 is based also on the hardness of the port 3 and the characteristic of the sealant 13, it is about 1-3 mm normally. Even if this length is somewhat long, in the present invention, the sheets 12 and 12 of the unwelded portion of the storage chamber 16 and the port 3 are in close contact with each other by shoulder seals 20 and 20 to be described later. Residual liquid hardly remains in the unwelded part. However, if the insertion length is too long, it is necessary to increase the distance that the shoulder seals 20 and 20 enter the storage chamber 16 side. Thereby, the close contact between the sheets 12 and 12 and the port 3 may be loosened. And if the length which inserts the welding base part tip of the port 3 in the storage chamber 16 is longer than the distance which penetrates into the storage chamber 16 side of the shoulder seals 20 and 20, a content liquid will remain outside the welding base part tip of the port 3. .

The port seal 19 simultaneously welds the sheets 12 and 12 to the outer peripheral surface of the port 3 and the plane of the sheets 12 and 12 at the time of the port 3. Both ends of the port seal 19 may reach the outer peripheral seal 15 and be connected.
However, since the COP resin used for the sealant 13 of the bag 2 in this embodiment is hard, the opening of the port mounting portion 17 is formed wider. In this case, as shown in A and B of FIG. 2, the port seal 19 does not reach the outer peripheral seal 15, and unwelded portions remain at both ends of the port seal 19. This unwelded portion is welded by the shoulder seal 20. As a result, the welding area between the sheets of the port seal 19 is reduced and control per die is facilitated, so that pinholes are less likely to occur at the welded portion between the sheets when the port seal 19 is formed.

Since the welding between the sheets 12 and 12 of the port seal 19 receives a peeling force by the port 3, the welding length X between the sheets 12 and 12 on both sides of the port 3 is preferably 5 mm or more. However, when the welding length X between the sheets 12 and 12 is long, it is difficult to ensure good mold contact, and it may be difficult to perform appropriate welding. Accordingly, the welding length X between the sheets 12 and 12 is preferably equal to or shorter than a length that can ensure a good mold contact. The length that can secure a good mold contact varies depending on the material and thickness of the sealant 13, the welding strength, the welding conditions, and the like, and therefore it is preferable to appropriately determine the length.
Since the COP sealant 13 used in this embodiment is hard and inferior in weldability, the allowable range is small for the welding conditions for obtaining high welding strength. Therefore, the welding length X between the sheets 12 and 12 is preferably 30 mm or less from the viewpoint of die contact.
The welding width Z of the port seal 19 is preferably 3 mm or more in order to secure a welding strength that can fix the port 3 in a liquid-tight manner. However, since the port seal 19 has a smaller capacity of the storage chamber 16 when the welding width Z is wide, the welding width Z is preferably 20 mm or less.

For the welding of the port seal 19, thermal welding or ultrasonic welding can be used. However, since the welding base portion of the port 3 having the COP resin layer is hard, the sheet 12 of the bag 2 may be torn and become a pinhole. Therefore, heat welding is preferable. Even in the case of heat welding, it is not preferable to perform heating or pressurization more than necessary, and it is sufficient that the welding strength between the sheets 12 and 12 is approximately the same as the welding strength of the outer peripheral seal 15. Since the port seal 19 is reinforced by the shoulder seal 20, it may be lower than the welding strength of the outer peripheral seal 15 in some cases.
Further, like the welding of the outer peripheral seal 15, it is preferable to rapidly cool and solidify the welded portion. The heating and pressurization and cooling of the sheets 12 and 12 may be performed a plurality of times.
The heat seal bar used for welding the port seal 19 preferably has a recess corresponding to the outer peripheral surface of the port 3.

In the present invention, as shown in FIGS. 2A and 2B, in order to protect the three-part welded portion of the port seal 19 from the impact of the content liquid or the like, The shoulder seals 20 and 20 are formed by welding the sheets 12 and 12 on both sides of the adjacent port. In order to protect the three-part welded portion, it is necessary to form the shoulder seals 20, 20 so that at least a part of the shoulder seals 20, 20 enter the storage chamber 16 side of the port seal 19.
When the port seal 19 is welded, the welded portion between the sheets 12 and 12 at the port 3 tends to be excessively heated. Therefore, the sheet 12 of the three-part welded portion may become thin and become a pinhole due to the impact of the content liquid or the like. However, the part closer to the accommodation chamber 16 than the port seal 19 receives the thermal history for the first time. Therefore, since the shoulder seals 20 and 20 can be welded at a temperature similar to that of the outer peripheral seal 15 lower than the welding temperature of the port seal 19, the seats 12 and 12 are welded as much as the outer peripheral seal 15 without being thinned. Strength is easily obtained.
For the welding of the shoulder seals 20 and 20, thermal welding or ultrasonic welding can be used, but for the same reason as the outer peripheral seal 15, thermal welding is preferable. Further, like the welding of the outer peripheral seal 15, it is preferable to rapidly cool and solidify the welded portion. The heating and pressurization and cooling of the sheets 12 and 12 may be performed a plurality of times.

As shown in A and B of FIG. 2, the distance Y into which the shoulder seals 20 and 20 enter the storage chamber 16 side is preferably equal to or longer than the length of the unwelded portion at the distal end of the weld base of the port 3. If the distance Y is equal to or longer than the length of the unwelded portion at the distal end of the port 3, the position of the distal end of the port 3 does not enter the accommodation chamber 16 side from the edge of the shoulder seals 20, 20.
The sheets 12 and 12 at the distal end of the welding base portion of the port 3 are in close contact with the distal end of the welding base portion of the port 3 by the port seal 19. However, if the shoulder seals 20 and 20 are not present, the inner solution can easily enter the sheets 12 and 12 on both sides of the port 3 from both sides of the port 3. However, in the present invention, the sheets 12 and 12 on both sides of the end of the port 3 are welded to form the shoulder seals 20 and 20, so the sheets 12 and 12 on both sides of the end of the port 3 are regulated by the shoulder seals 20 and 20. Since it adheres, the inner solution cannot easily enter.

That is, the distal end of the port 3 and the shoulder seals 20, 20 so that the distance Y that the shoulder seals 20, 20 enter the housing chamber 16 side of the port seal 19 is equal to or longer than the length of the unwelded portion at the distal end of the weld base of the port 3. When the end edge is disposed, unwelded portions regulated by the shoulder seals 20 and 20 are formed at the distal end of the welding base portion of the port 3 and on both sides thereof, but the content liquid does not easily enter here.
When the distance Y is equal to or longer than the length of the unwelded portion at the tip of the port 3, the position of the tip of the welded base of the port 3 does not enter the housing chamber 16 side from the edges of the shoulder seals 20 and 20, so Sometimes the liquid content naturally flows into port 3.
Therefore, by setting the distance Y that the shoulder seals 20 and 20 enter the storage chamber 16 side to be equal to or longer than the length of the unwelded portion at the tip of the port 3, the seats 12 and 12 are not substantially damaged at the time of welding. Since the tip does not enter the storage chamber 16, the remaining liquid can be extremely reduced when the content liquid is discharged.

Specifically, it is desirable that the distance Y into which the shoulder seals 20, 20 enter the storage chamber 16 side of the port seal 19 is 1 mm or more, preferably 3 mm or more on the side close to the port 3. When the distance Y into which the shoulder seals 20 and 20 enter is less than 1 mm, the effect of protecting the three-part welded portion may not be obtained.
The upper limit of the distance Y into which the shoulder seals 20 and 20 enter is not limited, but if the distance Y is too large, the width of the port seal 19 may be reduced or the capacity of the storage chamber 16 may be reduced. Therefore, it is preferable that the distance Y into which the shoulder seals 20 and 20 enter is appropriately determined according to the capacity and shape of the storage chamber 16. In addition, even if the shoulder seals 20 and 20 enter the storage chamber 16 side exceeding 5 mm, the effect of protecting the three-part welded portion cannot be expected to be greatly improved, and it may be difficult to smoothly continue with the outer peripheral seal 15. Therefore, the upper limit is usually about 10 mm.

  The edge of the port seal 19 on the side of the storage chamber 16 facing the storage chamber 16 faces the storage chamber 16 as a three-part welded portion where the front and back sheets 12 and 12 and the port 3 are welded. This is susceptible to peeling action such as impact of the content liquid. The shoulder seals 20 and 20 shorten the distance that the port seal 19 in the vicinity of the three-part welded portion faces the storage chamber 16 and make it difficult for the content liquid to enter. For this purpose, the shoulder seals 20 and 20 are provided by welding the sheets 12 and 12 at a portion as close as possible to the port 3. However, if the seal bar touches or comes too close to the welded portion between the port 3 and the front and back sheets 12, 12, the three-part welded portion is melted and easily peeled off. Accordingly, the shoulder seals 20 and 20 are welded in a direction further away along the port seal 19 from a portion slightly away from the port 3. That is, the three-part welded portion closest to the accommodation chamber 16 is an unwelded portion of the shoulder seals 20 and 20. Since the optimum width of the unwelded portion varies depending on the characteristics of the sealant, the welding temperature, the shape of the heat seal bar, and the like, it is preferable that the optimum width is determined in accordance with them.

Shoulder seals 20, 20 protect the three-part welded portion if the sheets 12, 12 near the three-part welded portion are welded together, and therefore do not need to be continuous with the port seal 19. However, in order to ensure protection, it is preferable that the port seal 19 is continuous. When the shoulder seals 20 and 20 are welded including the port seal 19, the port seal 19 is welded again, so that hot delamination occurs at a part of the welded portion between the sheets 12 and 12 of the port seal 19. Even if the welding strength is reduced, the shoulder seals 20 and 20 are used for repair. At the time of forming the shoulder seals 20, 20, the sheets 12, 12 covering the port 3 are welded to the port 3, so that the force for peeling the sheets 12, 12 at the port 3 does not act. Therefore, since it is easy to form the shoulder seals 20 and 20 including the port seal 19, reliable welding is possible.
The shoulder seals 20 and 20 may be provided only in the vicinity of the three-part welded portion. However, if the shoulder seals 20 and 20 are welded including all but the edge of the port seal 19 on the side of the accommodation chamber 16, the impact of the liquid content from the port seal 19 away from the three-part welded portion. There is no risk of pinholes due to the above.

Since the seat of this embodiment is hard, the port mounting portion 17 is preferably wide. Accordingly, as shown in FIGS. 2A and 2B, the shoulder seals 20 and 20 are formed so that the port seal 19 is short so as not to reach the outer peripheral seal 15, leaving unwelded portions at both ends. The seals 20 and 20 are preferably welded in a liquid-tight manner. The shoulder seals 20 and 20 ensure that the liquid tightness of the bag 2 is maintained. The shoulder seals 20 and 20 are preferably welded including the entire unwelded portion excluding the ports 3 at both ends of the port seal 19 and a part of the outer peripheral seal 15. As a result, the port seal 19 comes into contact with the internal solution only at the port 3 and is in a state like a narrow cove, so that the three-part welded portion is less susceptible to the impact of the internal solution.
Shoulder seals 20 and 20 are preferably welded including a part of outer peripheral seal 15 because there is no loss of liquid-tightness due to misalignment.

The shoulder seals 20 and 20 are configured so that the end edge on the storage chamber 16 side and the peripheral edge of the storage chamber 16 are smoothly continuous, and the end edge on the storage chamber 16 side of the shoulder seal is inclined toward the welding base of the port 3. It is preferable to weld. That is, in the present embodiment, the shoulder seals 20 and 20 are welded so as to be smoothly continuous with the outer peripheral seal 15 and to be inclined toward the welding base portion of the port 3 as shown in FIG. It is preferable.
In this case, the distance Y that the shoulder seals 20 and 20 enter the storage chamber 16 side of the port seal 19 is appropriately set within the same range (1 to 10 mm) as in the case of A in FIG. . The side far from the port is not particularly limited, and is appropriately set so as to be smoothly continuous with the outer peripheral seal 15.
Thereby, since the periphery of the storage chamber 16 inclines smoothly toward the welding base part of the port 3, discharge | emission of an internal solution becomes smooth and residual liquid can be decreased. In addition, the appearance is excellent.
When the bag 2 is a tube or a blow molded container, the shoulder seals 20 and 20 are welded together with the unwelded portion at the end of the port seal 19 including the folding line of the bag 2. Thereby, it becomes easy to fold the bag 2 of a tube and a shaping | molding container compactly.

FIG. 4 is a cross-sectional view illustrating an example of the port 3 used in the present embodiment and a mode in which the cylindrical body portion 5 is welded to the COP sealants 13 and 13 of the bag 2. Note that the adhesive layer and the adhesive resin layer are omitted. The welding base portion to be welded to the COP sealants 13 and 13 of the bag 2 of the port 3 is not a boat shape but a cylindrical shape. When the welding base has a boat-like shape, when the content liquid is discharged by its own weight by hanging a container with a port such as a drip, the content liquid tends to become a residual liquid due to surface tension from the upper surface of the welding base to the side welding part. On the other hand, it is preferable that the weld base has a cylindrical shape because no gap is formed between the front and back sheets until just before the port 3, so that the residual liquid is hardly formed.
The cylindrical portion 5 of the port 3 used in this embodiment may be a single-layer molded product, but is preferably a multilayer molded product having at least the innermost layer 9 and the surface layer 10 as shown in FIG. As shown in FIG. 5, the cylindrical body 5 (laminated structure is not shown) and the plug 4 are fitted and welded to the port 3. The plug part 4 is covered with a rubber plug 6 fitted into a coating resin 7.
FIG. 6 is a cross-sectional view showing another example of the plug part 4 and the cylindrical part 5 of the port 3. In the plug portion 4 of the port 3, a rubber plug 6 is covered with a coating resin 7 by insert molding. The cylindrical part 5 (laminated structure is not shown) and the plug part 4 are welded without being fitted.

As shown in FIG. 5 and FIG. 6, the port 3 of the present embodiment includes a rubber plug 6 and a plug body portion 4 that covers and holds a part of the rubber plug 6 with a coating resin 7. 11 is formed by welding.
The covering resin 7 of the plug body 4 is preferably the same resin as that forming the surface layer 10 of the multilayered cylindrical body 5. However, in the case where the cylindrical part 5 is composed of a single COP resin layer or in the case of the port 3 shown in FIG. 6, it is preferable that the coating resin 7 of the plug part 4 is a resin mainly composed of COP resin.

As a method of welding the flange portion 11 of the cylindrical body portion 5 and the coating resin 7 of the plug body portion 4, a welding method using heat generated by ultrasonic waves is preferable. Ultrasonic welding is suitable for welding hard COP resin layers, and the welding time is short. Therefore, ultrasonic welding is particularly preferable when the cylindrical body portion 5 is formed of a single COP resin layer or when the port 3 shown in FIG. 6 is used.
As another welding method, both the flange portion 11 of the cylindrical body portion 5 and a part of the coating resin 7 of the plug body portion 4 are brought close to the heating element, heated and melted in a non-contact state for a certain time, and then welded. It is also possible to do. As such a heating element, a conventionally known heating element can be used. An example of such a heating element is a nickel-based alloy manufactured by Inconel.

In the cylindrical body portion 5 of the port 3 of this embodiment, the innermost layer 9 in contact with the content liquid is a resin layer (COP resin layer) whose main component is COP resin in order to prevent adsorption and permeation of active components of the inner solution. It consists of
As the COP resin used for the cylindrical body part 5, from the viewpoint of obtaining good welding between the cylindrical body part 5 and the sealants 13 and 13 of the bag 2, the COP resin identical to or similar to the sealant 13 and 13 of the bag 2 or the above-mentioned It is preferable that the COP resin is a resin that can be used for the sealant 13 and has a glass transition temperature lower than that of the sealant 13 or 13 of the bag 2.

In this embodiment, in order to suppress the amount of the resin having COP resin as a main component and to ensure flexibility, and to improve the brittleness of the cylinder part 5, the surface of the cylinder part 5 is A PE resin layer is laminated as the surface layer 10. The PE resin layer is laminated by multicolor molding or insert molding of two or more colors.
And in order to ensure the weldability of the port 5, as shown in FIG. 4, a part of COP resin layer of the innermost layer 9 is exposed to the front end surface of the welding base part of the cylinder part 5 in a ring shape. The exposed COP resin layer is welded to the sealants 13 and 13 of the bag 2 together with the PE resin layer of the surface layer 10 in a band shape.
The portion of the innermost layer 9 where the COP resin layer is exposed on the tip surface of the weld base of the cylindrical body 5 is welded to the COP sealants 13 and 13 of the bag 2. Welding between COP resin layers has a narrow temperature range where good welding can be obtained, but if it can be properly welded, a welding strength of 30 N / 15 mm or more can be obtained, so that a container 1 with a port having excellent drop strength can be obtained. It becomes.
On the other hand, the PE resin layer on the surface of the weld base of the cylindrical body 5 absorbs or disperses the impact of the weld base when the weld base is dropped by the PE resin layer. Thereby, the intensity | strength with respect to the impact at the time of dropping improves.

In this embodiment, a band-shaped ring having only a COP resin layer without a PE resin layer is formed at least at the tip of the cylindrical body 5 on the welding base side. If this end is only the COP resin layer, even if this end is inserted into the storage chamber 16, it is possible to prevent adsorption of active ingredients and contamination of the content liquid. It is preferable to insert the end portion into the accommodating chamber 16 because the sheets 12 and 12 pressed against the ridgeline at the end portion of the port 3 by the heat seal bar when the port seal 19 is formed are not broken to form a pinhole.
In addition, the shoulder seals 20 and 20 cause the sheets 12 and 12 of the unwelded portion of the storage chamber 16 and the port 3 to be in close contact with each other, so that the amount of content liquid entering the unwelded portion is extremely small. Therefore, the effect that the tip of the port 3 does not substantially enter the storage chamber 16 is produced, so that the remaining liquid can be reduced when the content liquid is discharged.
In addition, although the length which inserts the welding base part tip of the port 3 in the storage chamber 16 is based also on the hardness of the port 3 and the characteristic of the sealant 13, it is about 1-3 mm normally.

In the present embodiment, the PE resin layer of the surface layer 10 of the cylindrical part 5 is preferably a layer mainly composed of PE resin polymerized by a metallocene catalyst.
PE polymerized by a catalyst other than a metallocene catalyst has a wide molecular weight distribution and contains a large amount of low softening point components and low molecular weight components. When welding to the COP sealant of the bag 2, it is considered that these components bleed out to the welding surface and cause the weldability to deteriorate.
On the other hand, when PE is polymerized with a metallocene catalyst, PE having a very low softening point component or low molecular weight component present at the weld interface of PE can be obtained. As a result, entanglement of the molecular chain of the COP resin and the molecular chain of the PE resin having a bulky molecular structure with a cyclic hydrocarbon group in the molecular skeleton easily occurs. If the PE is LLDPE, the molecule is linear, and the α-olefin side chain is appropriately introduced, so that the α-olefin side chain easily enters between the molecules. When welding to the COP sealants 13, 13, it becomes possible to obtain a stronger welding strength.

The conditions when such molecular chain entanglement occurs are a density of 880 to 970 kg / m ³ , preferably 900 to 960 kg / m ³ , more preferably 935 to 955 kg / m ³ . When the density is 935 to 955 kg / m ³ , the welding strength with the resin having COP resin as a main component is increased, the heat resistance is improved, and the temperature of the high temperature sterilization treatment can be increased to 115 ° C. or more. preferable. If the density is less than 880 kg / m ³ , the heat resistance may not be sufficient, and problems such as deformation of the port 3 may occur during high temperature sterilization. When the density exceeds 970 kg / m ³ , the welding strength with a resin containing COP resin as a main component is lowered, so that it can be used but the practical welding strength may not be obtained.

  In addition, the resin component content having a polystyrene-equivalent number average molecular weight of 3,000 or less by gel permeation chromatography analysis using toluene as a solvent is 1% by mass or less. It is preferable because there is no elution of low molecular weight components or adsorption of active ingredients in chemical solutions. Further, the number average molecular weight in terms of polystyrene by gel permeation chromatography analysis using toluene as a solvent is 10,000 to 200,000, preferably 20,000 to 100,000, more preferably 25,000 to 50,000. 000 is preferable because it is excellent in mechanical strength and heat resistance. The COP resin layer of the port 3 has almost no low softening point component or low molecular weight component derived from the COP resin, so that the molecular chains are easily entangled and high welding strength can be obtained.

In this embodiment, it is preferable that the PE resin layer of the surface layer 10 contains COP resin used for HDPE or sealants 13 and 13 in an amount of 40% by mass or less, preferably 30% by mass or less, because the heat resistance is improved. . However, if the blending ratio of HDPE exceeds 40% by mass, the welding strength with the sheets 12 and 12 may not be sufficient. On the other hand, when the blending ratio of the COP resin exceeds 40% by mass, the weld base becomes brittle and the drop strength may be lowered. HDPE contained in the PE resin layer preferably has a density of 935 to 970 kg / m ³ because it can impart appropriate hardness and high heat resistance to the port 3.

The COP resin is generally as small as 3 to 60% in elongation at break and is hard and brittle with a flexural modulus of 2000 to 3200 MPa. When the container with port 1 filled with the internal solution is accidentally dropped at the time of ultrasonic welding, fine cracks are generated in the cylindrical part 5 or the plug part 4 is ultrasonically welded to the cylindrical part 5 When doing so, there is a problem that dust generation increases. In many cases, the fine crack once entered cannot be visually confirmed, and when the inner solution is filled in the container 1 with a port, it may grow due to vibrations such as transportation and may cause liquid leakage. In particular, since the horn and the anvil are in direct contact with each other and vibrate at the time of ultrasonic welding, the cylindrical portion 5 is liable to have fine cracks.
In order to prevent generation of cracks, generation of fine particles, and dust generation, it is preferable to mix a rubber component, PE, and an antioxidant in the cylindrical body portion 5. As these blending methods, dry blend, melt blend, and the like are used.

As the rubber component, a thermoplastic elastomer is preferable because it contains less eluate. Especially thermoplastic elastomers such as styrene butadiene block copolymer, styrene butadiene styrene block copolymer, styrene isoprene block copolymer, styrene isoprene styrene block copolymer, and hydrogenated products thereof, styrene butadiene random copolymer, etc. Dispersion is preferable.
The PE is preferably the same as the PE resin polymerized by the metallocene catalyst used for the surface layer 10 of the cylindrical portion 5 of the port 3 because the adhesive strength of the laminated structure is increased.
As the antioxidant, phenolic antioxidants, phosphorus antioxidants, sulfur antioxidants, vitamin E, hindered amine light stabilizers and the like can be used alone or in combination.

  The rubber plug 6 held and embedded in the plug body portion 4 of the port 3 is made of rubber such as butyl rubber, isoprene rubber, chlorinated butyl rubber, silicon rubber, or the inner solution of the plug body portion 4. A laminated rubber stopper in which a fluorine-based resin, ultrahigh molecular weight polyethylene, high molecular weight polyethylene, LLDPE, polypropylene resin, or the like is attached as a protective layer to the surface in contact with the surface. Among these, when the rubber plug is a laminated rubber plug, when the rubber plug 6 is pierced with a needle such as a syringe, the rubber is missing and mixed into the content liquid, or the active ingredient of the content liquid is adsorbed to the rubber plug. It is preferable because problems such as interaction with the inner solution can be prevented. Moreover, you may produce the rubber stopper 6 using an elastomer resin. In this case, since there is little adsorption of the active ingredient of the content liquid even if there is no protective layer, it is preferable.

EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.
[Example 1]
[Production of Bag 2]
Density 900 kg / m ³ of reactor polymerization type ethylene-propylene-based elastomer layer / 30 [mu] m of PP based adhesive elastomer (manufactured by Mitsubishi Chemical Corp. MC719) layer / 50 [mu] m of the sealant 13 to a film by water-cooling multilayer inflation total thickness of 170μm Two sheets 12 made of a laminate of 250 μm were prepared. The sealant 13 has 40% by mass of COP resin ZEONEX manufactured by Nippon Zeon Co., Ltd. having a molecular structure of the above general formula (1) having a glass transition temperature of 130 ° C. in the main chain, and the above general formula (1 The glass transition temperature was adjusted to 115 ° C. by blending 60% by mass of COP resin ZEONOR made by Nippon Zeon Co., Ltd. having a molecular structure of

The seals 13 and 13 of the COP resin of the produced two sheets 12 and 12 were overlapped and the periphery was welded to form the outer peripheral seal 15. The four corners are arc-shaped and trimmed to have a width of 115 mm and a length of 170 mm, and a hole with a diameter of 15 mm is punched out on the upper side to form a storage chamber 16 and a non-welded port attachment portion 17 with a length of 50 mm as shown in FIG. A bag-like bag 2 having the same was produced.
The welding width of the outer peripheral seal 15 was 5 mm at both side edges and 3 mm at the narrowest upper side, and the welding conditions were heating and pressurization from both sides at 220 ° C. for 4 seconds. The welded portion was cooled immediately after welding with a cooling mold.

[Production of port 3]
Production of the cylindrical part 5:
The COP resin used for the sealant 13 of the bag 2 was blended with 1.0% by mass of a styrene thermoplastic elastomer as a rubber component to obtain a resin used for the innermost layer 9 of the cylindrical portion 5. Moreover, it was set as resin used for the surface layer 10 of the cylinder part 5 using the metallocene type | system | group LLDPE (product made from Ube Maruzen polyethylene) of density 935kg / m < ³ > independently.
The innermost layer 9 and the surface layer 10 were laminated and formed by a two-color molding method to produce the cylindrical body portion 5 of the port 3 shown in FIG. In addition, the resin of the innermost layer 9 was exposed with a width of 7 mm on the tip surface of the welded base portion of the cylindrical body portion 5. The cylindrical part 5 was made into a cylindrical shape having a total length of 40 mm and an outer diameter of a part corresponding to the welding base part of 17 mm.

Production of plug part 4:
Using the LLDPE resin used for the surface layer 10 of the cylindrical body portion 5, the coating resin 7 of the plug body portion 4 shown in FIG. In order to sandwich the rubber plug 6, the coating resin 7 hangs the periphery of the flange that swells in a flange shape into a ring shape. In order to fit the cylindrical body part 5 with the rubber plug 6 being held, the lower end of the hook part suspended downward was formed to have an acute angle in cross section. Then, a rubber plug 6 made of isoprene having a protective layer 8 made of a fluororesin adhered to the surface in contact with the inner solution was physically fitted into the coating resin 7 to obtain a plug body portion 4 shown in FIG.

[Formation of port seal 19]
A pair of portions 12 mm from the tip of the cylindrical body portion 5 of the port 3 is inserted as a welding base portion between the sheets 12 and 12 of the port mounting portion 17 of the manufactured bag 2, and a pair of recesses corresponding to the outer periphery of the port 3 is provided. A port seal 19 shown in FIG. 2A was formed by heating and pressurizing from the front and back with a seal bar. The port seal 19 has a width Z of 10 mm and a length of 30 mm in plan view.
When forming the port seal 19, the COP resin layer exposed on the weld base of the cylindrical body 5 was welded to the sheets 12 and 12 so that the width was 5 mm and the PE resin layer of the weld base was 5 mm wide. The tip portion where the COP resin layer having a width of 2 mm remained was not welded but remained in the storage chamber 16.
The length X of the welded portion between the sheets 12 on both sides of the port 3 was 7 mm. Then, an unwelded portion of about 5 mm was left at both ends of the port seal 19.
In this manner, the cylindrical portion 5 was welded to the COP sealants 13 and 13 of the bag 2 in the manner shown in FIG.
The port seal 19 was welded under pressure at 260 ° C. for 4 seconds from both sides. The welding part was cooled from both sides immediately after welding with a cooling mold.

[Formation of shoulder seals 20, 20]
The entire surface of the 5 mm unwelded portion left at both ends of the port seal 19 was liquid-tightly welded to form two shoulder seals 20 on the left and right.
When forming the shoulder seals 20 and 20, a heat seal bar having a width of 13 mm and a length of 17 mm is used, and the outer edge of the port seal 19 (opposite the housing chamber 16) and the outer edge of the shoulder seals 20 and 20 are used. 2, the inner edge of the shoulder seals 20, 20 (accommodating chamber 16 side) is 3 mm inside the edge of the inner side of the port seal 19, that is, the shoulder seals 20, 20 shown in FIG. It welded so that the distance Y which penetrates into the storage chamber 16 side from 19 might be set to 3 mm.
Further, the shoulder seals 20 and 20 were heated and pressurized so that the seal bar abuts the outer peripheral seal 15 beyond the end of the outer peripheral seal 15 from a position 1 mm away from the port 3. That is, the outer peripheral seal 15 was heated and pressurized again by the shoulder seals 20 and 20 over the inner side by about 5 mm from the end.
The shoulder seals 20 and 20 were heated and pressed from both sides at 220 ° C. for 4 seconds. The welded portion was cooled immediately after welding with a cooling mold.

[Filling of contents liquid and welding of plug part 4]
The bag 2 was filled with 100 ml of purified water as a content liquid from the cylindrical part 5. The plug part 4 is fitted to the cylinder part 5 and an ultrasonic sealer is used to support the flange part 11 of the cylinder part 5 on the anvil, and the upper surface of the plug part 4 is brought into contact with the horn. 4 was welded to complete the port 3 shown in FIG. 4 and the ported container 1 was sealed to prepare the ported container 1 shown in FIG.
At the time of welding, the ring-shaped portion formed at an acute angle in section of the coating resin 7 was melted and flattened, and was firmly welded so as to be liquid-tight with the flange portion 11 of the cylindrical body portion 5.

[Example 2]
When forming the shoulder seals 20, 20, a heat seal bar having a width of 11 mm is used so that the distance Y into which the shoulder seals 20, 20 shown in FIG. A container 1 with a port was produced in the same manner as in Example 1 except that welding was performed.
[Comparative Example 1]
When forming the shoulder seals 20, 20, a heat seal bar having a width of 10 mm is used so that the distance Y into which the shoulder seals 20, 20 shown in FIG. A container 1 with a port was produced in the same manner as in Example 1 except that welding was performed.

[Example 3]
When forming the shoulder seals 20 and 20, except for welding as shown in FIG. 2B using a substantially trapezoidal heat seal bar having a length of 17 mm, one side facing each other 12 mm and the other side 15 mm, Example 3 of the container 1 with a port was produced in the same manner as Example 1.
That is, the edge on the inner side of the shoulder seals 20, 20 (the storage chamber 16 side) is smoothly connected to the inner edge of the outer peripheral seal 15, and the edge on the storage chamber 16 side of the shoulder seals 20, 20 is connected to the port 3. It welded so that it might incline toward the front-end | tip of the welding base part which has not been welded.
In this case, the distance Y that the shoulder seals 20 and 20 shown in FIG. 2B enter the storage chamber 16 side with respect to the port seal 19 is 2 mm, which is the same length as the width of the unwelded portion at the tip of the port 3. And the unwelded part of the front-end | tip of the port 3 and the unwelded part of the shoulder seals 20 and 20 at the time of the port 3 continue with the same width. However, since the sheets 12 and 12 in the continuous unwelded portion are in close contact with each other by the port seal 19 and the shoulder seals 20 and 20, the ports 3 and the sheets 12 and 12 are in close contact with each other. The amount of content liquid is extremely small. Accordingly, when the content liquid is discharged, the tip of the welding base portion of the port 3 is substantially inclined and continuous with the edge of the shoulder seals 20 and 20 in the three-part welding portion facing the storage chamber 16.
Since the distance Y entering the storage chamber 16 side of the shoulder seals 20 and 20 is the same as the width of the unwelded portion at the distal end of the weld base of the port 3, the residual liquid at the time of discharging the content liquid naturally flows into the port 3 Flow into. That is, by making the distance Y into which the shoulder seals 20 and 20 enter the storage chamber 16 side be the same as the width of the unwelded portion at the tip of the port 3, the seats 12 and 12 are not substantially damaged at the time of welding. Since the tip of the welding base is located at the same position as the edge of the shoulder seals 20, 20 on the side of the storage chamber 16, the residual liquid can be extremely reduced when discharging the content liquid.

[Pressure resistance test]
The pressure resistance of the containers 1 with ports of Examples 1 and 2 and Comparative Example 1 was tested. When measuring the pressure strength, an internal pressure of 0.05 to 0.10 MPa · min was applied stepwise in increments of 0.01 MPa for every 10 bags of each sample. That is, the nozzle for jetting compressed air was brought into close contact with the opening of the plug 4 of the port 3, and the entire bag was submerged in water. Compressed air was supplied from the nozzle, a predetermined internal pressure was continuously applied for 1 minute, and air leakage at the port was visually inspected. The test results are shown in Table 1.

As a result, in Example 1, air leakage did not occur up to 0.08 MPa, and at 0.09 MPa, 1 out of 10 bags became a pinhole at the time of port 3 and air leakage occurred. Similarly, in Example 2, one bag out of 10 became a pinhole at the time of port 3 at 0.07 MPa, and air leaked.
On the other hand, in Comparative Example 1, as early as 0.06 MPa, 3 out of 10 bags became pinholes at the time of port 3, and at 0.07 MPa, all 10 bags became pinholes at the time of port 3 and air leaked. .

From this result, by welding so that the inner edge of the shoulder seals 20, 20 is more than 1 mm inner than the inner edge of the port seal 19, a three-part welded portion facing the storage chamber 16 is added. It has been found that it has a function of preventing pinholes by being protected from internal pressure.
Then, by welding so that the inner edge of the shoulder seals 20, 20 is 3 mm or more inner than the inner edge of the port seal 19, the three-part welded portion facing the storage chamber 16 is loaded with the content liquid. It was found that the function of preventing pinholes is remarkable.

  According to the present invention, even if the port is difficult to weld, for example, when the port is welded to a bag having a hard resin layer such as a resin mainly composed of PET, PAN, EVOH, or COP resin, It is possible to provide a container with a port in which a pinhole in the three-part welded portion is less likely to occur and a method for manufacturing the container with a port. In particular, it is possible to easily and reliably weld a port having a resin containing COP resin as a main component in the innermost layer to a bag having a resin mainly containing COP resin as a sealant. A container with a port capable of preventing adsorption and permeation of medicinal components with respect to the resin constituting the port is obtained. Thereby, it is useful in the field of a container with a port for medical use, which is filled with a preparation for intravenous infusion.

DESCRIPTION OF SYMBOLS 1 Container with a port 2 Bag 3 Port 4 Plug part 5 Cylinder part 6 Rubber plug 7 Cover resin 8 Protective layer 9 Inner layer 10 Surface layer 11 Cylinder part 12 of sheet | seat body 13 Sealant 14 Other layers 15 Outer seal 16 Accommodation Chamber 17 Port mounting part 18 Hanging part 19 Port seal 20 Shoulder seal

Claims (11)

A container with a port having a port for communicating the inside and outside of a storage chamber formed in a resin bag,
A port seal in which a welding base portion of the port is inserted between the seats of the port mounting portion left as an opening in a part of the peripheral edge of the storage chamber, and a non-welded portion is left at the tip, and the port seal is liquid-tightly welded,
Inside the edge of the port seal on the side of the storage chamber, only the sheets on both sides of the port that are continuous or close to the edge of the port seal on the side of the storage chamber are not welded at the time of the port. A container with a port, characterized by having a shoulder seal welded.   2. The container with a port according to claim 1, wherein a distance of the shoulder seal entering the storage chamber is equal to or longer than a length of an unwelded portion at a tip of the welded base.   The container with a port according to claim 1 or 2, wherein an edge of the shoulder seal on the storage chamber side is inclined and welded toward a welding base portion of the port.   The sheet of the bag has a water vapor permeation preventing ability to prevent water vapor permeation, a gas permeation preventive ability, a low molecular weight component permeation preventive ability, and a permeation or adsorption of an active component of the inner solution or a low resin contained in the resin. The container with a port according to any one of claims 1 to 3, comprising a functional layer having at least one preventive ability selected from the group consisting of an anti-deterioration ability that prevents alteration of the content liquid due to elution of molecular weight components.   The container with a port in any one of Claims 1-3 in which the sheet | seat of the said bag contains the layer which has a polyethylene terephthalate layer, a polyacrylonitrile layer, an ethylene-vinyl alcohol copolymer layer, or cyclic polyolefin resin as a main component.   The container with a port according to any one of claims 1 to 3, wherein the sealant of the bag has a cyclic polyolefin resin as a main component.   The container with a port according to claim 6, wherein at least an innermost layer of the port contains a cyclic polyolefin-based resin as a main component. A method for manufacturing a container with a port having a port for communicating inside and outside of a storage chamber formed in a resin bag,
A step of inserting a welding base portion of the port between sheets of a port attachment portion left as an opening portion at a part of the peripheral edge of the storage chamber, and forming a port seal in which liquid welding is performed leaving an unwelded portion at the tip. When,
Inside the edge of the port seal on the side of the storage chamber, forming a shoulder seal that welds only the sheets on both sides of the port that are continuous or close to the edge of the port seal on the side of the storage chamber; In this order. A method for manufacturing a container with a port.   The method for manufacturing a container with a port according to claim 8, wherein the shoulder seal is formed by welding the sheets together including all the edges of the port seal on the side of the accommodation chamber except for the port.   The method for manufacturing a container with a port according to claim 8 or 9, wherein the port seal is formed while leaving unwelded portions at both ends, and the unwelded portions at both ends of the port seal are welded in a liquid-tight manner with the shoulder seals.   11. The port attachment according to claim 8, wherein the shoulder seal is formed so that an edge of the shoulder seal on the storage chamber side is 1 mm or more inside from an edge of the port seal on the storage chamber side. Container manufacturing method.

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