JP2013210388A - Autoanalyzer - Google Patents

Abstract

An automatic analyzer capable of preventing deterioration of analysis data is provided.
In an automatic analyzer that dispenses a sample and a reagent into a reaction vessel and measures a mixed solution thereof, the dispensing probes for dispensing the sample or the reagent, 15, 16, and 16, or the mixed solution are stirred. To detect the position of the analysis unit, the analysis unit of the agitator 18, 19 or the suction probe 22 that sucks in order to measure the mixed solution, the arm that holds the analysis unit movably The analysis unit detection means 14b, 15b, 16b, 18b, 19b, 22b and whether the value based on the position detected by the analysis unit detection means is within a correction range determined for each inspection item, Determination means for determining whether or not the analysis unit can be corrected.
[Selection] Figure 2

Description

The present invention relates to an automatic analyzer that analyzes components contained in a liquid, and more particularly, to an automatic analyzer that dispenses a sample such as serum collected from a human and analyzes the components contained in the sample.

The automatic analyzer is intended for biochemical test items and immunological test items, etc., and changes in color tone and turbidity caused by the reaction of the mixture of the test sample and the reagent corresponding to the test item can be detected using a spectrophotometer, turbidimetric meter, etc. Optical data is measured by the photometric unit to generate analysis data represented by the concentration of various test item components in the test sample, the activity of the enzyme, and the like. In addition, among biochemical test items, electrolyte items such as sodium ion, potassium ion, and chlorine ion are electrolyte units having an ion selective electrode that selectively responds to each electrolyte and a reference electrode that generates a constant potential. By measuring, analytical data represented by the concentration in the test sample is generated.

In this automatic analyzer, a sample in a sample container is dispensed into a reaction container with a sample dispensing probe, and a reagent in the reagent container is dispensed into a reaction container with a reagent dispensing probe. Next, after stirring the mixed solution of the test sample and the reagent in the dispensed reaction container with a stirrer, the reaction container is irradiated with light and measured with a photometric unit. Further, the mixed solution is sucked from the reaction container with a suction probe and measured by the electrolyte unit.

Then, when dispensing the test sample, the arm is rotated to move the sample dispensing probe held in the arm horizontally to the stop position above the sample container, and by lowering the arm, The sample dispensing probe is advanced into the sample container and the test sample is aspirated.

At this time, for example, an automatic analyzer is known that can prevent the lower end of the sample dispensing probe from colliding with an obstacle and being damaged when the sample container is not set (see, for example, Patent Document 1). .)

By the way, each analysis unit of the sample dispensing probe that enters the sample container, the reagent dispensing probe that enters the reagent container, the stir bar that enters the reaction container, and the aspiration probe is formed in an elongated shape. For this reason, when the arm holding each analysis unit is rotated and each analysis unit moves horizontally, for example, to a stop position above the reaction vessel, each analysis unit bends if there is an obstacle in the movement direction. There is a fear.

JP 2000-55925 A

However, in the method of Patent Document 1, since obstacles other than the downward direction cannot be detected, if the bend is overlooked and used as it is, the stop position of each analysis unit, for example, to the reaction container position shifts, and the test sample or reagent There is a possibility that the analysis data deteriorates due to a decrease in the function of each analysis unit, such as a decrease in dispensing accuracy and a decrease in the stirring power of the mixed solution. In particular, the reaction containers, sample containers, and reagent containers that have been miniaturized to allow measurement with recent trace amounts of samples and reagents have narrow openings, so even if they are slightly bent, the analysis data A large impact. Then, when an abnormality is detected in the analysis data output after the measurement, it is necessary to repair and measure again, so that the test sample, the reagent, and the inspection time are wasted.

The present invention has been made to solve the above-described problems, and an object thereof is to provide an automatic analyzer that can prevent deterioration of analysis data.

In order to achieve the above object, the automatic analyzer of the present invention is a dispensing probe that dispenses the sample or the reagent in an automatic analyzer that dispenses a sample and a reagent into a reaction container and measures the mixed solution. Or an analysis unit of a stirrer that stirs the mixed solution or a suction probe that sucks in order to measure the mixed solution, an arm that holds the analysis unit movably, and a position of the analysis unit. Analysis unit detection means for detection and whether the value based on the position detected by the analysis unit detection means is within a correction range determined for each inspection item can be corrected for the analysis unit. And determining means for determining whether or not a state is present.

The block diagram which shows the structure of the automatic analyzer which concerns on the Example of this invention. The perspective view which shows the structure of the analysis part which concerns on the Example of this invention. The top view which shows arrangement | positioning of each unit of the analysis part regarding management of the sample dispensing probe which concerns on the Example of this invention. The figure which shows the sample dispensing arm which moved to the analysis unit detector upper direction along the track | orbit from the reference position which concerns on the Example of this invention. AA arrow sectional drawing which shows the analysis unit detector shown in FIG. The figure which shows the detail of a structure of the analysis control part which concerns on the Example of this invention. The figure which shows an example of the analysis unit management condition setting screen displayed on the display part which concerns on the Example of this invention. The flowchart which shows operation | movement of the automatic analyzer which manages a sample dispensing probe according to the "before and after measurement start" mode based on the Example of this invention. The flowchart which shows operation | movement of the automatic analyzer which manages a sample dispensing probe according to the "in measurement" mode based on the Example of this invention.

  Hereinafter, an embodiment of an automatic analyzer according to the present invention will be described with reference to FIGS.

FIG. 1 is a block diagram showing a configuration of an automatic analyzer according to an embodiment of the present invention. This automatic analyzer 100 dispenses each sample of a standard sample or test sample of each test item and a reagent corresponding to each test item, and generates standard data or test data by measuring the mixed solution. 25, an analysis control unit 27 that controls each unit related to the dispensing and measurement of each sample and reagent in the analyzing unit 25, and the dispensing of the unit of the analyzing unit 25, the stirring of the mixed solution, and the like. And an analysis unit management unit 30 for managing each analysis unit.

Further, the standard data and test data generated by the analysis unit 25 are processed to generate calibration data and analysis data for each inspection item, and the calibration data and analysis generated by the data processing unit 40. An output unit 50 that outputs data, an operation unit 60 that performs input operations of various command signals, an analysis control unit 27, an analysis unit management unit 30, a data processing unit 40, and an output unit 5
And a system control unit 70 that controls and controls zero.

FIG. 2 is a perspective view showing the configuration of the analysis unit 25. The analysis unit 25 reacts to a sample container 17 that accommodates each sample of a standard sample and a test sample, a disk sampler 5 that rotatably holds the sample container 17, and a component of an inspection item included in each sample. A reagent container 6 for storing a first reagent for diluting each of the first reagent system and the second reagent system and each sample of the one reagent system, and a reagent rack 1a for rotatably holding the reagent container 6 A reagent container 1 having a reagent container 1 containing a second reagent paired with a first reagent of a two-reagent system, a reagent container 2 having a reagent rack 2a for rotatably holding the reagent container 7, and a circle And a reaction disk 4 rotatably holding a plurality of reaction vessels 3 arranged on the circumference.

In addition, a sample dispensing probe 16 that performs dispensing for sucking each sample in the sample container 17 and discharging it into the reaction container 3, and a sample dispensing arm that holds the sample dispensing probe 16 so as to be rotatable and vertically movable. 10, a washing tank 16 a for washing the sample dispensing probe 16 every time when dispensing of each sample is completed, and an analysis unit detector 16 b for detecting the sample dispensing probe 16.

Also, a first reagent dispensing probe 14 for dispensing the first reagent in the reagent container 6 accommodated in the reagent storage 1 and discharging it into the reaction container 3 into which each sample has been dispensed, and a first reagent Reagent dispensing probe 1
A first reagent dispensing arm 8 that holds 4 in a rotatable and vertically movable manner, a washing tank 14a that cleans the first reagent dispensing probe 14 every time the first reagent dispensing is completed, and a first reagent dispensing probe 14 and an analysis unit detector 14b for detecting 14.

In addition, a first stirrer 18 that stirs the first mixed solution composed of each sample and the first reagent dispensed in the reaction container 3, and a first stirrer 18 that holds the first stirrer 18 so as to be rotatable and vertically movable. Stirring arm 20
And a washing tank 18a for washing the first stirring bar 18 every time the first mixed liquid is stirred, and the first stirring bar 1
8 and an analysis unit detector 18b for detecting 8.

Further, a second reagent dispensing probe 15 that performs dispensing by sucking the second reagent in the reagent container 7 stored in the reagent store 2 and discharging it into the reaction container 3 into which each sample and the first reagent are dispensed. A second reagent dispensing arm 9 that holds the second reagent dispensing probe 15 so that the second reagent dispensing probe 15 can be rotated and moved up and down, and a washing tank 15a that cleans the second reagent dispensing probe 15 every time the second reagent dispensing is completed. And an analysis unit detector 15b for detecting the second reagent dispensing probe 15.

Moreover, the 2nd stirring element 19 which stirs the 2nd liquid mixture which consists of each sample, 1st reagent, and 2nd reagent dispensed in the reaction container 3, and the 2nd stirring element 19 can be rotated and moved up and down. A second stirring arm 21 that is held in the tank, a washing tank 19a that cleans the second stirring bar 19 every time the second mixed liquid is stirred,
An analysis unit detector 19b for detecting the second stirring bar 19 is provided.

Further, a calibration liquid pot 22 a containing calibration liquid, a first mixed liquid in the reaction container 3 and a suction probe 22 for sucking the calibration liquid in the calibration liquid pot 22 a, and a first mixed liquid sucked by the suction probe 22 And an electrolyte unit 23 that measures, for example, sodium ion, potassium ion, and chlorine ion electrolytes contained in the calibration solution, a suction arm 24 that holds the suction probe 22 and the electrolyte unit 23 so as to be rotatable and vertically movable, and suction An analysis unit detector 22b for detecting the probe 22 is provided.

Further, the photometric unit 13 for optically measuring the first mixed solution and the second mixed solution in the reaction vessel 3 and the reaction after being measured by the reaction vessel 3 and the photometric 13 unit after being sucked by the suction probe 22. A cleaning unit 12 that performs cleaning and drying for using the container 3 again for measurement is provided.

The electrolyte unit 23 has a constant mixture with the ion selective electrode that selectively responds to each electrolyte component in the first mixed solution including the standard sample and the test sample diluted with the first reagent and the calibration solution. The standard data and the test data are generated by measuring the electromotive force between the reference electrodes that generate the potential, and the generated standard data and the test data are output to the data processing unit 40. The photometric unit 13 irradiates light to the first mixed solution and the second mixed solution including the standard sample and the test sample in the reaction container 3 that rotates, and the wavelength of each inspection item transmitted through the mixed solution. Standard data represented by absorbance and test data are generated based on the light detection signal. Then, the generated standard data and test data are output to the data processing unit 40.

The analysis control unit 27 includes a mechanism unit 28 that drives each unit of the analysis unit 25 and a control unit 29 that controls the mechanism unit 28. The mechanism unit 28 includes a mechanism that rotates the disk sampler 5 of the analysis unit 25, the reagent rack 1 a of the reagent storage 1, and the reagent rack 2 a of the reagent storage 2, and a mechanism that rotates the reaction disk 4. Also, a mechanism for rotating and moving the sample dispensing arm 10, the first reagent dispensing arm 8, the first stirring arm 20, the second reagent dispensing arm 9, the second stirring arm 21, and the suction arm 24, respectively, etc. It has.

The analysis unit management unit 30 in FIG. 1 has the sample dispensing arm 10 of the analysis unit 25 shown in FIG.
A moving distance detector 31 for detecting the moving distance of each of the first reagent dispensing arm 8, the first stirring arm 20, the second reagent dispensing arm 9, the second stirring arm 21, and the suction arm 24. Yes.

Further, the sample dispensing probe 16, the first reagent dispensing probe 14, and the first stirrer 1 having a linear and elongated shape of the analyzing unit 25 based on the moving distance detected by the moving distance detecting unit 31.
8. A determination unit 32 that determines the state of each analysis unit of the second reagent dispensing probe 15, the second stirring bar 19, and the suction probe 22 is provided. Furthermore, the correction part 33 which calculates | requires the correction | amendment stop position which correct | amended the stop position when it is in the state which can correct | amend the stop position of each analysis unit from the determination result of the determination part 32 is provided.

The data processing unit 40 includes a calculation unit 41 that processes standard data and test data output from the electrolyte unit 23 and the photometry unit 13 of the analysis unit 25 and generates calibration data and analysis data for each inspection item. And a data storage unit 42 for storing the standard data and analysis data generated by the unit 41.

The calculation unit 41 generates calibration data representing the relationship between the concentration and activity of each test item component and the standard data from the standard data output from the electrolyte unit 23 and the photometry unit 13 and the standard value of a preset standard sample. The generated calibration data is output to the output unit 50 and saved in the data storage unit 42.

In addition, calibration data of inspection items corresponding to the test data output from the electrolyte unit 23 and the photometry unit 13 is read from the data storage unit 42. Then, using the read calibration data, analysis data expressed as a concentration value or activity value is generated from the test data, and the generated analysis data is output to the output unit 50 and stored in the data storage unit 42.

The data storage unit 42 includes a memory device such as a hard disk, and stores the calibration data output from the calculation unit 41 for each inspection item. In addition, the analysis data of each inspection item output from the calculation unit 41 is stored for each test sample.

The output unit 50 includes a printing unit 51 that prints and outputs calibration data and analysis data output from the calculation unit 41 of the data processing unit 40 and a display unit 52 that displays and outputs the data. And the printing part 5
Reference numeral 1 includes a printer or the like, and prints calibration data and analysis data output from the calculation unit 41 on printer paper or the like according to a preset format.

The display unit 52 includes a monitor such as a CRT or a liquid crystal panel, and displays calibration data and analysis data output from the calculation unit 41. In addition, an analysis condition setting screen for setting analysis conditions of inspection items that can be inspected by the automatic analyzer 100, information on a test sample to be measured, and a test sample for setting test items of the test sample / An inspection item setting screen, an analysis unit management condition setting screen for setting management conditions for managing each analysis unit of the analysis unit 25, and the like are displayed.

The operation unit 60 includes input devices such as a keyboard, a mouse, a button, and a touch key panel. The operation unit 60 is used to set an analysis condition for each test item, to set information on a test sample to be measured, and to set a test item for the test sample. An analysis unit management condition setting operation, an analysis unit management operation for executing analysis unit management, a measurement start operation for executing measurement of a standard sample and a test sample, and the like are performed.

The system control unit 70 includes a CPU and a storage circuit. A command signal input by an input operation from the operation unit 60, analysis conditions for each inspection item, management conditions for the analysis unit, information on the test sample, and each test sample After storing the input information such as the inspection item information in the storage circuit, the system controls the analysis control unit 27, the analysis unit management unit 30, the data processing unit 40, and the output unit 50 based on the input information. Control the whole.

Next, referring to FIG. 1 to FIG. 6, the analysis control unit 2 that manages each analysis unit of the analysis unit 25.
7 and the operation of the analysis unit management unit 30 will be described. Hereinafter, management of the sample dispensing probe 16 will be mainly described, and the first reagent dispensing probe 14, the first stirring bar 18, the second reagent dispensing probe 15, the second stirring bar 19, and the suction probe 22 will be described. Since the operation is the same as in the case of the sample dispensing probe 16, its description is simplified.

FIG. 3 is a plan view showing the arrangement of each unit of the analysis unit 25 related to the management of the sample dispensing probe 16. FIG. 4 is a diagram showing the sample dispensing arm 10 that has moved from the reference position upward along the trajectory to the analysis unit detector 16b. FIG. 5 is a cross-sectional view taken along the line AA showing the analysis unit detector 16b shown in FIG. FIG. 6 is a diagram showing details of the configuration of the analysis control unit 27.

In FIG. 3, the sample dispensing arm 10 includes a first arm 101 that is disposed perpendicular to the rotation direction of the sample dispensing probe 16, and a first arm 101 that is disposed perpendicular to the first arm 101. And the second arm 102 having one end fixed to the upper end of the arm 101. Then, the rotation of the first arm 101 around the central axis in the longitudinal direction causes the other end of the second arm 102 to follow the direction indicated by the arrow R1 along the circular path indicated by the broken line and this R
It moves in the direction of arrow R2, which is the opposite direction to the one direction.

The sample dispensing probe 16 is arranged in parallel to the first arm 101 and is detachably attached to the other end of the second arm 102. Then, the second arm 10
The movement of 2 moves in the R1 direction and the R2 direction, which are rotation directions. In the following, the moving direction, the stopping position, and the moving distance of the sample dispensing arm 10 refer to the moving direction, the stopping position, and the moving distance of the other end portion.

Then, the sample dispensing arm 10 moves to a reference position, for example, a cleaning position T1 positioned above the cleaning tank 16a. Also, as shown in FIG. 4, R2 along the trajectory from the reference position.
The probe moves to the probe detection position T2 located above the analysis unit detector 16b, which is the position moved by the reference distance Ds in the direction. Further, the probe moves from the probe detection position T2 to the test sample position T3 positioned above the stop position of the sample container 17 that stores the test sample held in the disk sampler 5 that is moved in the R2 direction along the trajectory. To do. Further, it moves to the standard sample position T4 located above the stop position of the sample container 17 containing the standard sample held in the disk sampler 5, which is the position moved in the R2 direction along the trajectory from the test sample position T3. . Moreover, it moves to reaction container position T5 located above the stop position of reaction container 3, which is the position moved in the R1 direction along the trajectory from cleaning position T1. And after moving to each upper stop position of washing | cleaning position T1, test sample position T3, standard sample position T4, and reaction container position T5, it stops.

Moreover, after stopping at washing | cleaning position T1, it moves below, and after the sample dispensing probe 16 is wash | cleaned within the washing tank 16a, it moves up. In addition, after stopping at the test sample position T3, the sample moves downward, and the sample dispensing probe 16 sucks the test sample in the sample container 17, and then moves upward. Moreover, after stopping at the standard sample position T4, it moves down, and after the standard sample in the sample container 17 is sucked by the sample dispensing probe 16, it moves up. Further, after stopping at the reaction container position T5, it moves downward, and after the test sample or standard sample sucked by the sample dispensing probe 16 is discharged into the reaction container 3, it moves upward.

FIG. 5 is a cross-sectional view taken along line AA showing the analysis unit detector 16b shown in FIG. The analysis unit detector 16b includes a photosensor having a light emitting element 161 and a light receiving element that detects irradiation light from the light emitting element 161 disposed to face the light emitting element 161. Then, the sample dispensing arm 10 moves from the reference position in the R2 direction, for example, the test sample position T3
The sample dispensing probe 16 is detected when the vicinity of the lower end of the sample dispensing probe 16 crosses the irradiation light from the light emitting element 161 while moving to the position.

Here, when the sample dispensing probe 16 is in a normal state, the second arm 10 is parallel to the first arm 101 of the sample dispensing arm 10 as shown in FIG.
Since the sample dispensing arm 10 moves to the probe detection position T2, the sample dispensing probe 16 is detected. Then, the detection signal is output to the control unit 29 of the analysis control unit 27.

In addition, when the vicinity of the lower end of the sample dispensing probe 16 is in a state where it collides with an obstacle during movement in the R1 direction and is eccentric in the R2 direction, as shown in FIG. When 10 moves to the probe detection position T2, the vicinity of the lower end of the sample dispensing probe 16 is separated from the irradiation light of the light emitting element 161 by a distance D1 in the R2 direction. In this case, the sample dispensing arm 10 detects the sample dispensing probe 16 at a position away from the probe detection position T2 by a distance D1 in the R1 direction. Then, the detection signal is output to the control unit 29.

Furthermore, when the vicinity of the lower end of the sample dispensing probe 16 is bent and the lowermost end of the sample dispensing probe 16 is located above the height of the irradiation light of the light emitting element 161, FIG.
As shown in (c), the sample dispensing probe 16 cannot be detected during the movement between the reference position of the sample dispensing arm 10 and the sample position T3. Then, the non-detection signal is sent to the control unit 2
Output to 9.

The analysis unit detector 14b is a reagent housed in the reagent storage 1 from the reference reagent position, for example, the first reagent dispensing probe washing position above the washing tank 14a, along the trajectory of the first reagent dispensing arm 8. The first reagent dispensing arm 8 moves toward the first reagent position toward the first reagent position above the stop position of the container 6.
It is arranged at the position moved r1. Then, the detection signal when the first reagent dispensing probe 14 is detected while the first reagent dispensing arm 8 moves from the reference position to, for example, the first reagent position, or detection of the first reagent dispensing probe 14 is not detected. A non-detection signal when it is possible is output to the control unit 29.

The analysis unit detector 18b stops the reaction vessel 3 that stirs the first mixed solution from the reference position, for example, the first stirrer washing position above the washing tank 18a, along the trajectory of the first stirring arm 20. The first stirring arm 20 is arranged at a position moved by the reference distance Dm1 toward the reaction container position T7 above the position. Then, the first stirring arm 20 is moved from the reference position to, for example, the reaction vessel position T.
7, a detection signal when the first stirrer 18 is detected while moving to 7 or a non-detection signal when the first stirrer 18 cannot be detected is output to the control unit 29.

In addition, the analysis unit detector 15b is arranged along the path of the second reagent dispensing arm 9 from the reference reagent position, for example, the second reagent dispensing probe washing position above the washing tank 15a, in the reagent storage 2 The second reagent dispensing arm 9 is moved to the reference distance D in the direction of the second reagent position above the stop position of the container 7.
It is arranged at the position moved r2. Then, a detection signal when the second reagent dispensing probe 15 is detected while the second reagent dispensing arm 9 moves from the reference position to, for example, the second reagent position, or detection of the second reagent dispensing probe 15 is not detected. A non-detection signal when it is possible is output to the control unit 29.

In addition, the analysis unit detector 19b is arranged along the orbit of the second stirring arm 21 from the reference stirring position, for example, the second stirring bar cleaning position above the cleaning tank 19a. The 2nd stirring arm 21 is arrange | positioned in the position which the reference distance Dm2 moved to reaction container position T9 direction above a stop position. Then, a detection signal when the second stirrer 19 is detected while the second stirrer arm 21 moves from the reference position to, for example, the reaction vessel position T9, or when the second stirrer 19 cannot be detected. The non-detection signal is output to the control unit 29.

In addition, the analysis unit detector 22b reacts along the trajectory of the suction arm 24 above the stop position of the reaction container 3 that sucks the first mixed liquid from the calibration liquid position above the calibration liquid pot 22a, which is the reference position. The suction arm 24 is arranged at a position moved by the reference distance Dp in the direction of the container position T10. Then, the control unit outputs a detection signal when the suction probe 22 is detected while the suction arm 24 moves from the reference position to, for example, the reaction container position T10, or a non-detection signal when the suction probe 22 cannot be detected. 29.

FIG. 6 is a diagram showing details of the configuration of the analysis control unit 27. The mechanism unit 28 of the analysis control unit 27 includes mechanisms 281 to 286 and the like. The mechanism 281 includes, for example, a pulse motor that rotates and moves the sample dispensing arm 10 up and down, and a reference position detector 281 a that detects the reference position of the sample dispensing arm 10. The mechanism 282 includes the first reagent dispensing arm 8. And a reference position detector 282a for detecting a reference position of the first reagent dispensing arm 8 is provided.

The mechanism 283 includes a pulse motor that rotates and moves the first stirring arm 20 up and down, and a first motor.
A reference position detector 283a for detecting the reference position of the stirring arm 20 is provided, and the mechanism 284 has a second position.
A pulse motor for rotating and vertically moving the reagent dispensing arm 9 and a reference position detector 284a for detecting the reference position of the second reagent dispensing arm 9 are provided.

Further, the mechanism 285 includes a pulse motor that rotates and moves the second stirring arm 21 up and down, and a second motor.
A reference position detector 285a for detecting the reference position of the stirring arm 21 is provided. The mechanism 286 includes a pulse motor for rotating and moving the suction arm 24 up and down and a reference position detector 286a for detecting the reference position of the suction arm 24. Yes.

And each reference position detector 281a, 282a, 283a, 284a, 285a, 28
6a outputs each detected reference position detection signal to the control unit 29.

The control unit 29 controls the mechanisms 281 to 286 of the mechanism unit 28 and the like.
6 etc.

The control unit 291 detects the reference position of the sample dispensing arm 10 based on the reference detection signal output from the reference position detector 281a of the mechanism 281. Next, each predetermined number of drive pulses are supplied to the mechanism 281 to move the sample dispensing arm 10 from the reference position to each upper stop position of the cleaning position T1, the test sample position T3, the standard sample position T4, and the reaction container position T5. Moving. Also,
Moves up and down at each upper stop position.

Further, the sample dispensing arm 10 is moved based on the detection signal or the non-detection signal output from the analysis unit detector 16b of the analysis unit 25 by the movement of the sample dispensing arm 10 from the reference position to the test sample position T3. Detection drive pulse supplied to the mechanism 281 from the reference position until the sample dispensing probe 16 is detected by the analysis unit detector 16b,
Alternatively, information on a predetermined number of non-detection drive pulses supplied to the mechanism 281 between the reference position and the test sample position T3 is output to the movement distance detection unit 31 of the analysis unit management unit 30.

Each control unit 292, 294 is provided with each reference position detector 282a, 28 of each mechanism 282, 284.
The reference position of each of the first and second reagent dispensing arms 8 and 9 is detected by the reference detection signal output from 4a. Next, a predetermined number of drive pulses are supplied to the mechanisms 282 and 284, and the first and second reagent dispensing arms 8 and 9 are moved from the reference positions to the first and second reagent dispensing probe washing positions, The first and second reagent positions and the upper stop positions of the reaction container positions T6 and T8 for discharging the first and second reagents are moved. Moreover, it moves up and down at each upper stop position.

In addition, each detection output from each analysis unit detector 14b, 15b of the analysis unit 25 by movement of each first and second reagent dispensing arm 8, 9 from each reference position to each first and second reagent position. Based on the signal or each non-detection signal, each first and second reagent dispensing is performed by each analysis unit detector 14b, 15b from each reference position to move each first and second reagent dispensing arm 8, 9 Detection drive pulses supplied to the mechanisms 282 and 284 until the probes 14 and 15 are detected, or predetermined supplies supplied to the mechanisms 282 and 284 between the reference positions and the first and second reagent positions. Information on the number of non-detection drive pulses is output to the movement distance detection unit 31.

Each control unit 293, 295 is provided with each reference position detector 283a, 28 of each mechanism 283, 285.
The reference position of each of the first and second stirring arms 20 and 21 is detected based on the reference detection signal output from 5a. Next, a predetermined number of drive pulses are supplied to the mechanisms 283 and 285, and the first and second stirring arms 20 and 21 are moved from the reference positions to the first and second stirring bar cleaning positions and the reaction vessel positions T7. , T9 to each upper stop position. Moreover, it moves up and down at each upper stop position.

In addition, each reaction container position T7, T from each reference position of each first and second stirring arm 20, 21.
9 to move each of the first and second stirring arms 20 and 21 based on each detection signal or each non-detection signal output from each analysis unit detector 18b and 19b of the analysis unit 25 by moving to 9. Each analysis unit detector 18b, 19b from the reference position causes each first and second stirrer 1
The detection drive pulses supplied to the mechanisms 283 and 285 before the detection of 8, 19 or the predetermined number of pulses supplied to the mechanisms 283 and 285 between the reference position and the reaction container positions T7 and T9. Information on the non-detection drive pulse is output to the movement distance detection unit 31.

The control unit 296 detects the reference position of the suction arm 24 based on the reference detection signal output from the reference position detector 286a of the mechanism 286. A predetermined number of drive pulses are then applied to mechanism 286.
The suction arm 24 is moved from the reference position to each of the upper stop positions of the calibration liquid position and the reaction container position T10. Moreover, it moves up and down at each upper stop position.

Further, based on the detection signal or non-detection signal output from the analysis unit detector 22b of the analysis unit 25 due to the movement of the suction arm 24 from the reference position to the reaction container position T10, the analysis unit is detected from the reference position. Information on the detection drive pulse supplied to the mechanism 286 until the suction probe 22 is detected by the vessel 22b, or a predetermined number of non-detection drive pulses supplied to the mechanism 286 from the reference position to the reaction container position T10. It outputs to the movement distance detection part 31.

The movement distance detection unit 31 of the analysis unit management unit 30 is a control unit 29 in the analysis control unit 27.
The movement distance of each arm moved from each reference position is detected based on the information of the detection drive pulse or the non-detection drive pulse output from each control unit 291 to 296. Then, information on each detected moving distance is output to the determination unit 32.

Here, the detection position of the sample dispensing probe 16 by the analysis unit detector 16b from the reference position or the moving distance of the sample dispensing arm 10 that has moved to the test sample position T3 is detected. The first and second reagent dispensing probes 14 and 15 detected by the analysis unit detectors 14b and 15b from the reference positions, or the first and second reagent positions moved to the first and second reagent positions, respectively.
And the movement distance of the 2nd reagent dispensing arm 8 and 9 is detected. Further, the first and second stirring arms 20 moved from the reference positions to the detection positions of the first and second stirrers 18 and 19 by the analysis unit detectors 18b and 19b or the reaction container positions T7 and T9. , 21 is detected. Furthermore, the moving distance of the suction arm 24 moved from the reference position to the detection position of the suction probe 22 by the analysis unit detector 22b or the reaction container position T10 is detected.

The determination unit 32 is based on a distance difference between the arms, which is a difference between the movement distance of each arm output from the movement distance detection unit 31 and each of the reference distances Ds, Dr1, Dm1, Dr2, Dm2, and Dp set in advance. The state of each analysis unit is determined.

If the distance difference between the arms is within an allowable range, it is determined that the analysis unit is attached to each arm, for example, within an error range, and the analysis unit held by each arm is in a normal state.

Here, when the distance difference of the sample dispensing arm 10 is within the allowable range, the lower end of the sample dispensing probe 16 at each upper stop position of the sample dispensing arm 10 is the opening of the sample container 17 and the reaction container 3. Since it is located at the center or near the center, each sample can be dispensed with high accuracy. Moreover, since it is located in the center of the opening part of the washing tank 16a or the center vicinity, each sample adhering to the sample dispensing probe 16 can be washed off.

Further, when the difference in distance between the first and second reagent dispensing arms 8 and 9 is within an allowable range,
The lower ends of the first and second reagent dispensing probes 14 and 15 at the upper stop positions of the second reagent dispensing arms 8 and 9 are the centers or centers of the openings of the reagent containers 6 and 7 and the reaction container 3, respectively. Since it is located in the vicinity, each first and second reagent can be accurately dispensed. Moreover, since it is located in the center of the opening part of each washing tank 14a, 15a or the center vicinity, each 1st and 2nd reagent adhering to each 1st and 2nd reagent dispensing probe 14 and 15 can be washed off. it can.

Further, when the distance difference between the first and second stirring arms 20 and 21 is within an allowable range, the first and second stirring bars 18 and the second stirring bars 18 at the upper stop positions of the first and second stirring arms 20 and 21, respectively. Since the lower end of 19 is located at the center of the opening of the reaction vessel 3 or near the center, the first and second mixed liquids in the reaction vessel 3 can be uniformly stirred. Moreover, since it is located in the center of the opening part of each washing tank 18a, 19a or the center vicinity, each 1st and 2nd liquid mixture adhering to each 1st and 2nd stirring element 18 and 19 can be washed off. .

Furthermore, when the distance difference of the suction arm 24 is within the allowable range, the lower end of the suction probe 22 at each upper stop position of the suction arm 24 is at or near the center of the opening of the calibration liquid pot 22a and the reaction container 3. The calibration solution in the calibration solution pot 22a and the reaction vessel 3
The first mixed liquid can be sucked in a preset amount.

If the distance difference between the arms is within a correction range that is larger than the allowable range, it is determined that each arm is in a correctable state. By this determination, it is determined that each upper stop position of each arm is corrected, and the analysis unit held in each arm can function normally to obtain good analysis data. Is output to the correction unit 33.

Here, when the difference in the distance of the sample dispensing arm 10 is within the correction range, the sample dispensing probe 16 can enter the cleaning tank 16a, the sample container 17, and the reaction container 3. The probe 16 is eccentric. For this reason, the lower end of the sample dispensing probe 16 at each upper stop position of the sample dispensing arm 10 is connected to the sample container 17 and the reaction container 3.
Since it is shifted from the vicinity of the center of the opening, there is a possibility that the dispensing accuracy of each sample is lowered. Further, the sample dispensing probe 16 is displaced from the vicinity of the center of the opening of the cleaning tank 16a.
There is a possibility that each sample adhered to the surface cannot be washed out sufficiently.

Further, when the difference in distance between the first and second reagent dispensing arms 8 and 9 is within the correction range, each first
And the second reagent dispensing probes 14 and 15 in the washing tanks 14a and 15a and the reagent containers 6 and 7 respectively.
The first and second reagent dispensing probes 14 and 15 are eccentric. Therefore, the lower ends of the first and second reagent dispensing probes 14 and 15 at the upper stop positions of the first and second reagent dispensing arms 8 and 9 are connected to the reagent containers 6 and 7 and the reaction container 3, respectively. Since the vicinity of the center of the opening is deviated, the dispensing accuracy of each of the first and second reagents may be reduced. Moreover, since it has shifted | deviated from the center vicinity of each washing tank 14a and 15a, there exists a possibility that each 1st and 2nd reagent adhering to each 1st and 2nd reagent dispensing probe 14 and 15 cannot fully be washed off. There is.

Further, when the difference in distance between the first and second stirring arms 20 and 21 is within the correction range, each first
The second stirrers 18 and 19 can enter the cleaning tanks 18a and 19a and the reaction vessel 3, but the first and second stirrers 18 and 19 are eccentric. For this reason, the lower ends of the first and second stirrers 18 and 19 at the upper stop positions of the first and second stirring arms 20 and 21 are displaced from the vicinity of the center of the opening of the reaction vessel 3, There is a possibility that the stirring power of each of the first and second mixed liquids in the reaction vessel 3 is reduced. Moreover, since it has shifted | deviated from the center vicinity of the opening part of each washing tank 18a, 19a, there exists a possibility that each 1st and 2nd liquid mixture adhering to each 1st and 2nd stirring element 18 and 19 cannot fully be washed off. There is.

Furthermore, when the distance difference of the suction arm 24 is within the correction range, the suction probe 22 can enter the calibration liquid pot 22a and the reaction container 3, but the suction probe 22 is eccentric. For this reason, since the lower end of the suction probe 22 at each upper stop position of the suction arm 24 is shifted from the vicinity of the center of the opening of the calibration liquid pot 22a and the reaction container 3, the calibration liquid and the reaction container in the calibration liquid pot 22a. There is a possibility that the preset amount of the first mixed liquid in 3 cannot be sucked.

In order to determine the correction range more strictly, for example, in the case of the sample dispensing probe 16, for example, the simultaneous reproduction accuracy of the analysis data obtained by the analysis of the inspection item in which the error factor of the dispensing accuracy of each sample accounts is large. What is necessary is just to confirm and determine by experiment. Each of the other analysis units may be carried out in the same manner as in the case of the sample dispensing probe 16 so as to be determined based on the analysis data of the inspection item having a large error factor due to the function of the analysis unit.

Further, when the distance difference between the arms is an abnormal range larger than the correction range, it is determined that the analysis unit held in each arm is in an abnormal state. By this determination, even if each upper stop position of each arm is corrected, it is determined that the analysis unit held in each arm does not function normally and good analysis data cannot be obtained. The system control unit 70
Output to.

Here, when the distance difference of the sample dispensing arm 10 is in an abnormal range, the sample dispensing probe 16 cannot be moved into any of the cleaning tank 16a, the sample container 17, or the reaction container 3. Further, when the distance difference between the first and second reagent dispensing arms 8 and 9 is in an abnormal range, the first and second reagent dispensing probes 14 and 15 are placed in the cleaning tanks 14a and 15a or in the reagent containers. Cannot enter into 6 and 7. Further, each of the first and second stirring arms 20, 21
Are within the correction range, the first and second stirrers 18 and 19 are connected to the respective washing tanks 18a,
19a or the reaction vessel 3 cannot be entered. Furthermore, when the distance difference between the suction arms 24 is within the correction range, the suction probe 22 is placed in the calibration liquid pot 22a or the reaction container 3.
Cannot enter inside.

The correction unit 33 obtains a correction stop position obtained by correcting each upper stop position of each arm based on the distance difference information of each arm output from the determination unit 32, and uses the obtained correction stop position information as the control unit 2.
It outputs to each control part 291 thru | or 296 which controls each 9 arm. Control units 291 to 29
6, based on the information on the correction stop position output from the correction unit 33, the upper stop position of each arm that moves from the subsequent reference position is changed.

Here, when the movement distance of the sample dispensing arm 10 is larger than the reference distance Ds, each upper stop position of the sample dispensing arm 10 is, for example, half the distance difference in the direction of moving from the reference position to the analysis unit detector 16b. The correction stop position shifted by a distance equal to or less than the distance difference such as the distance of the distance is obtained.

Further, when the movement distance of the sample dispensing arm 10 is smaller than the reference distance Ds, each upper stop position of the sample dispensing arm 10 is, for example, a distance in a direction opposite to the direction of moving from the reference position to the analysis unit detector 16b. A correction stop position shifted by a distance equal to or less than a distance difference such as a half of the difference is obtained.

Thereby, the lower end of the sample dispensing probe 16 at each correction stop position of the sample dispensing arm 10 can be shifted to the vicinity of the center of the opening of the cleaning tank 16a, the sample container 17, and the reaction container 3, and each sample Can be dispensed with high accuracy. Moreover, each sample adhering to the sample dispensing probe 16 can be washed away.

Further, when the movement distances of the first and second reagent dispensing arms 8 and 9 are larger than the reference distances Dr1 and Dr2, the upper stop positions of the first and second reagent dispensing arms 8 and 9 are A correction stop position is obtained by shifting the distance from the reference position to the analysis unit detectors 14b and 15b by a distance less than the distance difference. Further, when the movement distances of the first and second reagent dispensing arms 8 and 9 are smaller than the reference distances Dr1 and Dr2, the upper stop positions of the first and second reagent dispensing arms 8 and 9 are A correction stop position that is shifted by a distance equal to or less than the distance difference in the direction opposite to the direction of movement from each reference position to each analysis unit detector 14b, 15b is obtained.

As a result, the lower ends of the first and second reagent dispensing probes 14 and 15 at the correction stop positions of the first and second reagent dispensing arms 8 and 9 are respectively connected to the reagent containers 6 and 7, the reaction containers 3, And it becomes possible to shift to the center vicinity of the opening part of each washing tank 14a and 15a, and can dispense each 1st and 2nd reagent accurately. Moreover, each 1st and 2nd reagent adhering to each 1st and 2nd reagent dispensing probe 14 and 15 can be washed away.

Furthermore, when the moving distance of each 1st and 2nd stirring arm 20 and 21 is larger than each reference distance Dm1 and Dm2, each upper stop position of each 1st and 2nd stirring arm 20 and 21 is set from each reference position. A correction stop position shifted by a distance equal to or smaller than the distance difference in the direction of movement to each analysis unit detector 18b, 19b is obtained. When the movement distances of the first and second stirring arms 20 and 21 are smaller than the reference distances Dm1 and Dm2, the upper stop positions of the first and second stirring arms 20 and 21 are moved from the reference positions. A correction stop position shifted by a distance equal to or smaller than the distance difference in the direction opposite to the direction of movement to each analysis unit detector 18b, 19b is obtained.

Thereby, the lower ends of the first and second stirrers 18 and 19 at the upper stop positions of the first and second stirring arms 20 and 21 are connected to the centers of the openings of the reaction vessel 3 and the cleaning tanks 18a and 19a. The first and second mixed liquids in the reaction vessel 3 can be uniformly stirred. Moreover, each 1st and 2nd liquid mixture adhering to each 1st and 2nd stirring element 18 and 19 can be washed out.

Furthermore, when the moving distance of the suction arm 24 is larger than the reference distance Dp, the suction arm 2
4 is obtained by shifting each stop position 4 by a distance less than or equal to the distance difference in the direction of moving from the reference position to the analysis unit detector 22b. Further, the moving distance of the suction arm 24 is the reference distance Dp.
Is smaller than the reference position, the analysis unit detector 2
A correction stop position shifted by a distance equal to or smaller than the distance difference in the direction opposite to the direction moving to 2b is obtained.

As a result, the lower end of the suction probe 22 at each upper stop position of the suction arm 24 can be shifted to the vicinity of the center of the calibration liquid pot 22a and the opening of the reaction container 3, and the calibration liquid and reaction in the calibration liquid pot 22a can be shifted. A predetermined amount of the first mixed liquid in the container 3 can be sucked.

Thus, when each arm is in a correctable state, the sample dispensing probe 16 obtains a correction stop by correcting each upper stop position of each arm and stops at the calculated correction stop position. A decrease in sample dispensing accuracy can be prevented in advance. Further, in the first and second reagent dispensing probes 14 and 15, it is possible to prevent a decrease in dispensing accuracy of the first and second reagents. Furthermore, in the 1st and 2nd stirring elements 18 and 19, the fall of the stirring power of a 1st and 2nd liquid mixture can be prevented beforehand. Furthermore, in the suction probe 22,
A suction failure can be prevented in advance.

Hereinafter, an example of the operation of the automatic analyzer 100 that manages the sample dispensing probe 16 in the analyzer 25 will be described with reference to FIGS. 1 to 9. The management of each analysis unit of the first reagent dispensing probe 14, the second reagent dispensing probe 15, the first stirrer 18, the second stirrer 19, and the suction probe 22 is managed by the sample dispensing probe 16. Since the operation is the same as in the case of, the description thereof is omitted.

FIG. 7 is a diagram illustrating an example of the analysis unit management condition setting screen displayed on the display unit 52. 8 and 9 are flowcharts showing the operation of the automatic analyzer 100.

In FIG. 7, the analysis unit management condition setting screen 53 sets the timing for managing the analysis unit set in the “analysis unit” column for setting each analysis unit of the analysis unit 25 to be managed and the “analysis unit” column. And “Management Mode” column. Then, by the operation from the operation unit 60, information on each management condition set in each column is stored in the storage circuit of the system control unit 70 and displayed on the display unit 52.

In the column of “analysis unit”, “sample dispensing probe” which is the sample dispensing probe 16, “first reagent dispensing probe” which is the first reagent dispensing probe 14, and “first reagent” which is the first stirrer 18. “1 stirrer”, “second reagent dispensing probe” which is the second reagent dispensing probe 15, “second stirring bar” which is the second stirring bar 19, and “aspiration probe” which is the suction probe 22 are displayed. ing. Then, “L” is displayed in the dialog box 531 by an input operation for setting, for example, the sample dispensing probe 16 from the operation unit 60. In addition, since each analysis unit other than the sample dispensing probe 16 is not set, each dialog box 532 is set.
536 are blank.

When an input operation for setting the first reagent dispensing probe 14 is performed, “L” is displayed in the dialog box 532, and when an input operation for setting the first stirrer 18 is performed, the dialog box 533 displays “ "" Is displayed. In addition, when an input operation for setting the second reagent dispensing probe 15 is performed, “L” is displayed in the dialog box 534, and the second stirring bar 19 is displayed.
When an input operation for setting is performed, “Re” is displayed in the dialog box 535.

Further, when an input operation for setting the suction probe 22 is performed, “Le” is displayed in the dialog box 536.

In the “management mode” column, four modes of “before and after measurement start”, “after measurement start”, “during measurement”, and “before measurement end” are displayed. Then, by an input operation for setting, for example, two modes “before and after measurement” and “during measurement” from the operation unit 60, a dialog box 537 corresponding to “before and after measurement” and a dialog corresponding to “during measurement” are displayed. Box 53
“Re” is displayed in 9. Also, the dialog boxes 5538 and 540 corresponding to “after measurement start” and “before measurement end” which are not set are blank.

Here, if the analysis unit management operation is performed from the operation unit 60 during the standby of the automatic analyzer 100 by the setting of “before and after measurement start”, the management of the analysis unit set in the “analysis unit to be managed” column is performed. Execute. In addition, when a measurement start operation is performed from the operation unit 60 during standby of the automatic analyzer 100 by setting the “after measurement start” or “before measurement end” mode, an operation for measuring a standard sample or a test sample is performed. The management of the analysis unit set in the column “Managed analysis unit” is executed before starting or before each unit of the analysis unit 25 after the operation of measuring the standard sample or the test sample is stopped. .

Furthermore, when a measurement start operation is performed from the operation unit 60 with the setting of “during measurement”, management of each analysis unit is executed during measurement of the standard sample or the test sample. If the sample dispensing probe 16 is set in the “analysis unit” column, management is executed for each dispensing of the standard sample or the test sample by the sample dispensing probe 16. Further, when the first and second reagent dispensing probes 14 and 15 are set, management is executed for each dispensing of the first and second reagents. Furthermore,
When the first and second stirrers 18 and 19 are set, management is executed for each stirring of the first and second mixed liquids. Furthermore, if the suction probe 22 is set, management is executed every time the calibration liquid is sucked.

Next, the sample dispensing probe 16 set in the “analysis unit” column is managed according to the “before and after measurement start” mode set in the “management mode” column of the analysis unit management condition setting screen 53 shown in FIG. The operation of the automatic analyzer 100 will be described.

FIG. 8 is a flowchart showing the operation of the automatic analyzer 100 that manages the sample dispensing probe 16 according to the “before and after measurement start” mode. The storage circuit of the system control unit 70 stores analysis unit management conditions set on the analysis unit management condition setting screen 53 shown in FIG. And if analysis unit management operation is performed from the operation part 60, the automatic analyzer 100 will start operation | movement (step S1).

Based on the analysis unit management conditions set on the analysis unit management condition setting screen 53, the system control unit 70 supplies the sample dispensing probe of the analysis unit 25 to the analysis control unit 27, the analysis unit management unit 30, and the output unit 50. 16 management is instructed. The control unit 29 and the analysis unit management unit 30 in the analysis control unit 27 manage the sample dispensing probe 16 based on an instruction from the system control unit 70, and a management process S2 including steps S21 to S27.
And step S3 is performed.

In the management process S2, the control unit 291 of the control unit 29 controls the mechanism 281 of the mechanism unit 28 to move the sample dispensing arm 10. Then, the reference position detector 281a of the mechanism 281
The sample dispensing arm 10 is moved to the reference position by the reference detection signal from (Step S).
21). Next, the sample moves from the reference position toward the test sample position T3 (step S22).

Based on the detection signal or non-detection signal output from the analysis unit detector 16b of the analysis unit 25 while moving from the reference position to the test sample position T3, the sample dispensing arm 10
The sample dispensing probe 1 from the reference position by the analysis unit detector 16b
The analysis unit management unit stores information on detection drive pulses supplied to the mechanism 281 until 6 is detected or information on a predetermined number of non-detection drive pulses supplied to the mechanism 281 between the reference position and the sample position T3. It outputs to 30 movement distance detection parts 31.

The moving distance detection unit 31 detects the detection position of the sample dispensing probe 16 by the analysis unit detector 16b from the reference position or the test sample based on the information of the detection drive pulse or the non-detection drive pulse output from the control unit 291. The moving distance of the sample dispensing arm 10 that has moved to the position T3 is detected. Then, the information on the detected movement distance of the sample dispensing arm 10 is obtained from the determination unit 3.
Output to 2.

The determination unit 32 determines the state of the sample dispensing probe 16 based on the distance difference that is the difference between the movement distance of the sample dispensing arm 10 and the reference distance Ds output from the movement distance detection unit 31.

When the distance difference between the sample dispensing arms 10 is within the allowable range (Yes in Step S23), it is determined that the sample dispensing probe 16 is in a normal state, and Step S3 is the next step of the management process S2. Migrate to If it is out of the allowable range (step S
23 No), the process proceeds to step S24.

After “No” in step S23, when the distance difference of the sample dispensing arm 10 is within the correction range (Yes in step S24), the process proceeds to step S25. If it is out of the correction range (No in step S24), the process proceeds to step S27.

After “Yes” in step S <b> 24, the determination unit 32 determines that the sample dispensing probe 16 is in a correctable state, and outputs information on the distance difference of the sample dispensing arm 10 to the correction unit 33. The correction unit 33 obtains a corrected stop position by correcting each upper stop position of the sample dispensing arm 10 based on the distance difference information of the sample dispensing arm 10 output from the determination unit 32 (
Step S25).

Then, the information of the obtained correction stop position is output to the control unit 291 and the system control unit 70. The control unit 291 corrects each upper stop position of the sample dispensing arm 10 that moves from the subsequent reference position based on the information on the correction stop position output from the correction unit 33. Further, the system control unit 70 displays the information on the correction stop position of the sample dispensing arm 10 output from the correction unit 33 on the display unit 52 (step S26).

In this way, by displaying the correction stop position of the sample dispensing arm 10 on the display unit 52, the operator of the automatic analyzer 100 can correct the sample dispensing probe 16 and the sample dispensing arm 10 can be corrected. The correction stop position can be quickly notified. Further, by correcting each upper stop position of the sample dispensing arm 10 based on the information of the correction stop position, it is possible to prevent a decrease in dispensing accuracy of each sample by the sample dispensing probe 16 in advance.

After “No” in step S 24, the determination unit 32 determines that the sample dispensing probe 16 is in an abnormal state and outputs the abnormality information to the system control unit 70. The system control unit 70 displays the abnormality information of the sample dispensing probe 16 output from the determination unit 32 as a display unit 52.
(Step S27).

Thus, by displaying the abnormality information of the sample dispensing probe 16 on the display unit 52, it is possible to promptly notify the operator that the sample dispensing probe 16 is in an abnormal state. As a result, it is possible to prevent deterioration of analysis data, and it is possible to prevent waste of the test sample, the first reagent, and the second reagent.

After “Yes” in step S23, or after step S26 or S27, the control unit 291 moves the sample dispensing arm 10 to the reference position (step S3).

Then, after the sample dispensing arm 10 stops at the reference position, the system control unit 70 instructs the analysis control unit 27, the analysis unit management unit 30, and the output unit 50 to end the management, whereby the automatic analyzer 100 is The operation is terminated (step S4).

Next, the automatic analyzer 100 that manages the sample dispensing probe 16 according to the “measuring” mode set in the “management mode” column of the analysis unit management condition setting screen 53 shown in FIG.
The operation of will be described.

FIG. 9 is a flowchart showing the operation of the automatic analyzer 100 that manages the sample dispensing probe 16 according to the “measuring” mode.

The storage circuit of the system control unit 70 has an analysis unit management condition setting screen 53 shown in FIG.
The management conditions for the analysis unit set in step 1 are saved. In addition, information on the test sample to be measured set on the test sample / inspection item setting screen displayed on the display unit 52 and information on the test item of the test sample are stored. Then, it is assumed that the test sample to be measured set on the test sample / inspection item setting screen is, for example, one type, and the inspection items set for the test sample are, for example, five types. Further, a sample container 17 containing a test sample to be measured is housed in the disk sampler 5, and reagent containers 6 and 7 containing first and second reagents corresponding to the inspection items of the test sample are reagent containers 1. , 2.

The operation of the flowchart shown in FIG. 8 is executed, and using the automatic analyzer 100 in which the sample dispensing probe 16 is confirmed to be normal, the test sample set on the test sample / inspection item setting screen is displayed. When a measurement start operation is performed from the operation unit 60 in order to perform measurement, the automatic analyzer 100 starts operation (step S11).

The system control unit 70 performs analysis control based on the analysis unit management conditions set on the analysis unit management condition setting screen 53 and information on the test sample and test items set on the test sample / test item setting screen. The control unit 27, the analysis unit management unit 30, the data processing unit 40, and the output unit 50 are instructed to manage the analysis unit and measure the test sample. Control unit 2 of analysis control unit 27
9 starts the measurement of the test sample set on the test sample / inspection item setting screen by controlling the mechanism unit 28 to operate each unit of the analysis unit 25.

The disk sampler 5 is rotated so that the sample container 17 containing the test sample is moved to the test sample position T3.
Move down. The control unit 291 moves the cleaning sample dispensing arm 10 to a position where the sample dispensing probe 16 can be cleaned by the cleaning tank 16a. Then, after the sample dispensing probe 16 is cleaned, it moves to the reference position.

In dispensing the test sample for the n-th (n = 1) inspection item, the control unit 291 moves the sample dispensing arm 10 in the direction of the test sample position T3. The management process S2 is executed in parallel with the movement from the reference position toward the test sample position T3.

Then, after “Yes” in step S23 in step S2 or step S26, the process proceeds to step S12 after step S2. Further, step S2 in the management step S2
7, the process proceeds to step S13 after the management step S2.

If “yes” in step S23 or after step S26, n is less than 5 (No in step S12), the process returns to step S2. When n is 5 (Yes in Step S12), the control unit 291 moves the sample dispensing arm 10 to the reference position (Step S13).
).

After step S <b> 27, the system control unit 70 stops the dispensing operation of the test sample for the n-th inspection item in the control unit 29 based on the abnormality information of the sample dispensing probe 16 output from the determination unit 32. Let The control unit 291 moves the sample dispensing arm 10 to the reference position (step S13).

Thus, based on the abnormality information of the sample dispensing probe 16, the sample dispensing arm 1
By stopping the operation of 0, it is possible to prevent waste of the test sample, the first reagent and the second reagent, and the inspection time.

When all the analysis data of each inspection item is output to the output unit 50 after “Yes” in Step S12, or when abnormality information is output to the display unit 52 after Step S27, the system control unit 70 performs analysis. By instructing the control unit 27, the analysis unit management unit 30, the data processing unit 40, and the output unit 50 to end the measurement of the test sample, the automatic analyzer 100 ends the operation (step S14).

According to the embodiment of the present invention described above, each analysis unit detector 16b, 14b, 18b, 15b, 19b, 22b for detecting each analysis unit is provided and moved from each reference position to a predetermined upper stop position. Each analysis unit detector 16b, 14b, 18b, 15b, 1
Based on the detection signal or non-detection signal of each analysis unit output from 9b and 22b, it is possible to detect the movement distance of each arm that holds each analysis unit movably.

Then, the detected movement distance of each analysis unit and each reference distance Ds, Dr1, Dm1, Dr.
If each distance difference, which is a difference between 2, Dm2, and Dp, is within an allowable range, it can be determined that each analysis unit is in a normal state.

If each distance difference is within the correction range, it is determined that each analysis unit is in a correctable state, and each upper stop position of the arm that holds each analysis unit is corrected to correct the analysis unit. It is possible to obtain good analysis data by functioning. Further, by displaying the corrected correction stop position information of each arm on the display unit 52, the operator can quickly determine that each analysis unit can be corrected and the correction stop position of the arm holding the analysis unit. Can let you know.

Furthermore, when each distance difference is larger than the correction range, it can be determined that each analysis unit is in an abnormal state. And the operation | movement of the arm holding the analysis unit can be stopped. Further, by displaying the abnormality information of each analysis unit on the display unit 52, it is possible to quickly inform the operator that the analysis unit is abnormal.

As described above, it is possible to prevent deterioration of the analysis data and reduce waste of the test sample, the reagent, and the test time.

1, 2 Reagent storage 1a, 2a Reagent rack 3 Reaction container 4 Reaction disk 5 Disc sampler 6, 7 Reagent container 8 First reagent dispensing arm 9 Second reagent dispensing arm 10 Sample dispensing arm 12 Washing unit 13 Photometric unit 14 First reagent dispensing probe 14a, 15a, 16a, 18a, 19a Cleaning tank 14b, 15b, 16b, 18b, 19b, 22b Analysis unit detector 15 Second reagent dispensing probe 16 Sample dispensing probe 17 Sample container 18 First Stirrer 19 Second stirrer 20 First stirrer arm 21 Second stirrer arm 22 Suction probe 22a Calibration liquid pot 23 Electrolyte unit 24 Suction arm 25 Analysis unit 27 Analysis control unit 28 Mechanism unit 29 Control unit 40 Data processing unit

Claims (8)

In an automatic analyzer that dispenses samples and reagents into a reaction vessel and measures the mixture,
An analysis unit that is either a dispensing probe that dispenses the sample or the reagent, a stirrer that stirs the mixed solution, or a suction probe that sucks to measure the mixed solution;
An arm for movably holding the analysis unit;
Analysis unit detection means for detecting the position of the analysis unit;
Determining whether or not the analysis unit can be corrected by determining whether or not a value based on the position detected by the analysis unit detection means is within a correction range determined for each inspection item. And an automatic analyzer. The analysis unit detection means is arranged at a position moved a reference distance from a reference position along the trajectory of the arm,
A movement distance detecting means for detecting a movement distance of the arm moved from the reference position to the detection position of the analysis unit by the analysis unit detection means;
The determination means determines that the analysis unit can be corrected when a distance difference that is a difference between the movement distance detected by the movement distance detection means and the reference distance is within the correction range; 2. The automatic analyzer according to claim 1, wherein when the distance difference is greater than the correction range, the analysis unit is determined to be in an abnormal state. The correction means for obtaining a correction stop position obtained by correcting the stop position of the arm when the value based on the position detected by the analysis unit detection means is within a correction range. The automatic analyzer described. Output means for outputting analysis data generated by measurement of the mixed solution;
2. The determination unit according to claim 1, wherein when the value based on the position detected by the analysis unit detection unit is within the correction range, the correction information of the arm is output to the output unit. 4. The automatic analyzer according to any one of items 1 to 3. Output means for outputting analysis data generated by measurement of the mixed solution;
The determination means outputs abnormality information of the analysis unit to the output means when a value based on the position detected by the analysis unit detection means is not within the correction range. The automatic analyzer according to any one of 1 to 4. 6. The arm according to claim 1, wherein the determination unit stops the operation of the arm when a value based on the position detected by the analysis unit detection unit is not within the correction range. The automatic analyzer according to claim 1. 7. The method according to claim 1, further comprising an electrolyte unit that measures the mixed solution sucked from the suction probe, or a photometric unit that optically measures the mixed solution in the reaction vessel. The automatic analyzer described. 8. The stop position is a position where the reaction vessel stops.
The automatic analyzer according to any one of the above.