JP2013032319A - Method for controlling keratotic plug regeneration, and kit for controlling keratotic plug regeneration - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a keratotic plug regeneration inhibitor capable of effectively controlling the regeneration of a keratotic plug without causing a rough dry skin.SOLUTION: The method for controlling keratotic plug regeneration is characterized by applying to the skin the keratotic plug regeneration inhibitor containing one or two or more selected from a group consisting of lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid, glycolic acid, and salts thereof, after applying to the skin a skin cleaning agent containing a polyoxyethylene fatty acid ester. Also, provided is a kit consisting of the skin cleaning agent and the keratotic plug regeneration inhibitor.

Description

  The present invention relates to a method for inhibiting the regeneration of horn plugs and a kit for inhibiting horn plug regeneration. More specifically, the present invention relates to a method for suppressing horn plug regeneration and a kit for suppressing horn plug regeneration that exhibit a very high effect for suppressing horn plug regeneration.

  The problem of horn plugs is one of the top items among women's skin problems. A horn plug is a mixture of sebum and exfoliated horny layer clogged in the pores (Non-Patent Document 1). It is not preferable because it looks and feels rough. It is also said that leaving this untreated leads to skin problems.

  As a countermeasure, it is common to remove them with cleaning materials or packs, and a great many products are sold. There are many prior art documents related to horn plug removal, for example, those containing N-acylamino acid salts (Patent Document 1), those containing lauroyl sarcosine (Patent Document 2), room temperature liquid oil and N, N, N ′, N Combination of '-tetrakis (2-hydroxypropyl) ethylenediamine, nonionic surfactant, etc. (Patent Document 3), combination of dimer acid diester and mono fatty acid polyglyceryl (Patent Document 4), dimer acid diester and polyoxyethylene fatty acid glyceryl (Patent Document 5), dibasic acid diester having 6 to 20 carbon atoms (Patent Document 6), and the like. However, the removal efficiency is not so high, and even if it is removed, it may be regenerated in about one week, and the skin often becomes rough by repeating the processing with the pack.

  So far, it has been known that organic acids such as tannic acid, lactic acid, citric acid, tartaric acid, and glutamic acid and salts thereof are effective in suppressing regeneration of horn plugs (see Patent Documents 7 to 8). However, the effect is quite difficult to realize, and even in the market there are products that tighten pores, such as astringent lotion, but there are no products that claim to make it difficult to regenerate horn plugs. . In addition, organic acids alone may cause rough skin and sensory irritation, and it is difficult to use them generally as cosmetics.

Japanese Patent No. 3857182 Japanese Patent No. 4058399 Japanese Patent No. 4285699 JP 2007-119393 A JP 2007-119394 A JP 2007-230929 A JP-A-4-360834 JP-A-4-360830

Tochio Takumi, Fragrance Journal, August 2008, 28-32

  The present invention has been made in view of the above circumstances, and provides a method for suppressing the regeneration of horn plugs extremely effectively without causing rough skin, and a horn plug regeneration suppression kit used in the method. With the goal.

  As a result of repeated studies by the present inventors to solve the above problems, the use of a specific cleaning material and a specific horn plug regeneration inhibitor has an extremely effective effect of suppressing the regeneration of horn plugs without causing rough skin. As a result, the present invention has been completed.

  That is, the present invention is selected from lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid, glycolic acid, and salts thereof after applying a skin cleanser containing polyoxyethylene fatty acid ester to the skin. The present invention relates to a method for inhibiting the regeneration of horn plugs, which comprises applying to the skin a horn plug regeneration inhibitor containing one or more of the above.

  In the present invention, the horn plug inhibitor is further selected from fatty acid soaps, higher alkyl sulfates, N-acyl glutamates, N-acyl lower alkyl taurates, betaine surfactants, and polyoxyalkylene phytosterols. It is related with the said square plug reproduction | regeneration suppression method containing the 1 type, or 2 or more types of surfactant.

  The present invention also relates to the above-described method for inhibiting regeneration of horn plugs, further comprising an anti-skin roughening agent in the horn plug inhibitor.

  In the present invention, the anti-skin roughening agent is one or more selected from polyoxyethylene / polyoxypropylene / dimethyl ether (= “PEG / PPG dimethyl ether”), tranexamic acid, and pantothenyl ethyl ether. The present invention also relates to the above-mentioned method for suppressing the regeneration of horn plugs.

  In addition, the present invention relates to a horn plug regeneration suppression kit comprising the above skin cleansing agent and horn plug regeneration inhibitor.

  INDUSTRIAL APPLICABILITY According to the present invention, there are provided a horn plug regeneration suppression method and a horn plug regeneration suppression kit that exhibit an extremely high effect of suppressing horn plug regeneration.

  Hereinafter, the present invention will be described in detail.

<Skin cleansing agent>
The skin cleanser used in the present invention contains a polyoxyethylene fatty acid ester as an active ingredient. Examples of the polyoxyethylene fatty acid ester include POE sorbitan fatty acid ester, POE fatty acid ester, POE glycerin fatty acid ester, POE having at least one fatty acid residue selected from oleic acid residue, isostearic acid residue, and lauric acid residue. Examples include propylene glycol fatty acid ester, POE hydrogenated castor oil surfactant, sorbitan surfactant, POE oleyl ether, POE lauryl ether, and POE isostearyl ether. However, it is not limited to these examples. One or more polyoxyethylene fatty acid esters can be used.

  1-60 mass% is preferable, and, as for the compounding quantity of the polyoxyethylene fatty acid ester in a skin cleansing material, More preferably, it is 5-40 mass%. By setting it as the said compounding quantity range, in the combined use with a horn plug regeneration inhibitor, a very excellent horn plug regeneration inhibitory effect can be obtained. If the blending amount is less than 1% by mass, the effect as a component cannot be sufficiently exhibited. On the other hand, even if blending exceeds 60% by mass, an increase in the effect commensurate with the blending amount cannot be expected.

  Any base such as an oil type, a foam type, and a liquid type may be used as the skin cleansing material. In the present invention, an oil type liquid preparation (cleansing oil or the like) is particularly preferably used. In the case of an oil-type cleaning material (oil-based cleaning material), in addition to the above essential components, a liquid oil component at room temperature is blended as a main component. Examples of such liquid oil include hydrocarbon oils such as liquid paraffin (mineral oil), squalane, olifin oligomer, and light isoparaffin; 2-ethylhexanoic acid triglyceride, 2-ethylhexanoic acid cetyl, 2-ethylhexanoic acid Ester oil such as pentaerythritol, triethylolpropane 2-ethylhexanoate, 2-ethylhexyl palmitate, isocetyl isononanoate, isopropyl myristate; jojoba oil, olive oil, macadamia nut oil, cottonseed oil, teaseed oil, safflower oil, rice bran Examples include natural vegetable oils such as oils; silicone oils such as decamethylpentacyclosiloxane, octamethyltetracyclosiloxane, dimethylsiloxane, and methylphenylsiloxane.

  When mix | blending a liquid oil component, it is preferable to mix | blend in the range of 50-95 mass% in a skin cleansing material, More preferably, it is 60-80 mass%. If the blending amount is 50% by mass, the effect as a component cannot be sufficiently exhibited. On the other hand, even if blending exceeds 95% by mass, an increase in the effect commensurate with the blending amount cannot be expected.

  Further, as components that can be blended in addition to these liquid oils, various components that are usually blended in the field of cosmetics and pharmaceuticals can be added within a range that does not impair the effects of the present invention. Examples of such components include lower alcohols such as ethanol and isopropyl alcohol, and polyhydric alcohols such as glycerin, 1,3-butylene glycol, isoprene glycol, 1,3-butanediol, dipropylene glycol, and propylene glycol. , Anionic surfactants, amphoteric surfactants such as N-alkyl-N, N-dimethylaminoacetic acid betaine, alkyldimethylamine oxide, cationic surfactants, nonionic surfactants, bactericides, UV absorbers , Antioxidants, fragrances, water and the like.

<Square plug regeneration inhibitor>
[Organic acids]
The horn plug regeneration inhibitor used in the present invention contains an organic acid selected from lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid and glycolic acid, or a salt thereof. The salt is not particularly limited as long as it can be generally used in cosmetics. For example, alkali metal salts (sodium salt, potassium salt, lithium salt, etc.), alkaline earth metal salts (calcium salt, magnesium salt) Etc.), ammonium salts, organic amine salts (monoethanolamine salts, diethanolamine salts, triethanolamine salts, etc.). Of these, lactic acid, succinic acid, salicylic acid, pyrrolidone carboxylic acid, or salts thereof are preferred. These organic acids can be used alone or in combination of two or more.

  The blending amount of the organic acids is preferably 0.001 to 20% by mass, more preferably 0.05 to 5% by mass in the horn plug regeneration inhibitor used in the present invention. If it is less than 0.001% by mass, the effect as the component (a) cannot be sufficiently exhibited. On the other hand, even if it exceeds 20% by mass, an increase in the effect commensurate with the compounding amount cannot be expected.

[Surfactant]
In addition to the above organic acids, the horn plug regeneration inhibitor used in the present invention includes fatty acid soap, higher alkyl sulfate ester salt, N-acyl glutamate salt, N-acyl lower alkyl taurine salt, betaine surfactant, It is preferable to contain a surfactant selected from oxyalkylene phytosterols.

  Examples of the fatty acid soap include sodium laurate, potassium laurate, sodium palmitate, potassium palmitate and the like.

  Examples of higher alkyl sulfate salts include sodium lauryl sulfate and potassium lauryl sulfate.

  Examples of N-acylglutamate include sodium N-lauroylglutamate, potassium N-lauroylglutamate, disodium N-cocoylglutamate, potassium when N-cocoylglutamate, N-myristoyl-L-glutamate, N-myristoyl-L-glutamic acid And monopotassium.

  As the N-acyl lower alkyl taurine salt, an N-acyl methyl taurine salt is particularly preferable. Specific examples include N-coconut oil fatty acid-sodium N-methyltaurine, N-coconut oil fatty acid-N-methyltaurine triethanolamine, N-coconut oil fatty acid-N-methyl taurine magnesium etc. are mentioned.

  Examples of betaine surfactants include 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl dimethylaminobutyric acid betaine, alkyl betaines (eg, lauryl betaine), amide betaines, sulfobetaines, and the like. It is done. Moreover, those salts are mentioned. Examples of the salt include sodium salt and potassium salt, but are not limited to these examples.

  As the polyoxyalkylene phytosterol, those having a POE addition mole number of about 20 to 50 are preferable.

  As these surfactants, polyoxyethylene phytosterol, potassium laurate, lauryl betaine and the like are particularly preferable.

  The blending amount of these surfactants is preferably 0.001 to 20% by mass, more preferably 0.05 to 5% by mass in the horn plug regeneration inhibitor. If it is less than 0.001% by mass, the effect as a blending component cannot be sufficiently exhibited. On the other hand, even if it exceeds 20% by mass, an increase in the effect commensurate with the blending amount cannot be expected.

[Anti-skin roughening agent]
It is preferable that an anti-skin roughening agent is further added to the horn plug regeneration inhibitor used in the present invention. The anti-skin roughening agent is not particularly limited as long as it is a component that exhibits an anti-skin roughening effect that can be generally used in a topical skin preparation. For example, tranexamic acid, tranexamic acid methylamide, 1-piperidinepropionic acid, vitamin E-acetate Glycerin, xylitol, erythritol, polyoxyethylene / polyoxypropylene / dimethyl ether (= “PEG / PPG dimethyl ether”), pantothenyl ethyl ether, or salts thereof (sodium salt, potassium salt, etc.). Moreover, plant extracts (hypericum, chamomile, etc.) are also mentioned. Of these, tranexamic acid (salt), PEG / PPG dimethyl ether, pantothenyl ethyl ether, and the like are preferable. The PEG / PPG dimethyl ether preferably has a PEG / PPG molar ratio of about 1: 2 to 5: 1.

The blending amount of the anti-skin roughening agent is preferably 0.001 to 20% by mass, more preferably 0.05 to 5% by mass in the horn plug regeneration inhibitor. If it is less than 0.001% by mass, the effect as an anti-skin rough component cannot be sufficiently exhibited. On the other hand, even if it exceeds 20% by mass, an increase in the effect commensurate with the compounding amount cannot be expected.
For the horn plug regeneration inhibitor used in the present invention, other optional additives usually used in skin external preparations such as cosmetics and pharmaceuticals, for example, fats and oils, waxes, hydrocarbons, etc., within the range not impairing the effects of the present invention. Oil, higher fatty acid, higher alcohol, synthetic ester oil, silicone oil, water-soluble polymer, chelating agent, lower alcohol, polyhydric alcohol, pH adjuster, antioxidant, powder component, perfume, water, etc. as required It can mix | blend suitably. However, it is not limited to these examples.

  The dosage form of the horn plug regeneration inhibitor used in the present invention is not particularly limited and can be used as a liquid preparation, a gel preparation, a cream, a sheet-impregnated preparation, and the like, but a liquid preparation is particularly preferable. In addition, it is preferable that the angle plug regeneration inhibitor has a pH of about 3.0 to 8.0.

<Method and kit for inhibiting regeneration of horn plug of the present invention>
In this invention, after washing | cleaning skin using the said skin washing | cleaning material, the square plug regeneration inhibitor can be suppressed very effectively by applying the said square plug regeneration inhibitor to skin. The method of application to the skin can be appropriately performed depending on the dosage form, such as impregnation with cotton or the like, application by spraying, or the like. Moreover, it can be conveniently used by selling as a cosmetic kit in which the above-mentioned cleaning agent and a keratin plug regeneration inhibitor are set.

  Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited thereto. Unless otherwise specified, all the amounts are mass%.

(Example 1: Synergistic effect of skin cleanser and horn plug regeneration inhibitor by human test)
1. Sample The skin cleansing agent and the horn plug regeneration inhibitor used in this example are as follows.

≪Skin cleansing oil (cleaning oil) ≫
Mineral oil 67.54 (mass%)
Diphenylsiloxyphenyl trimethicone 2
Ethanol 1
Isostearyl alcohol 1
Cetyl isooctanoate 20
Polyethylene glycol diisostearate-12 5
Polyethylene glycol diisostearate-8 1
Polyethylene glycol monostearate-10 2
Tetrahydroxypropylethylenediamine 0.01
Dibutylhydroxytoluene 0.05
Ion exchange water 0.4

≪Square plug regeneration inhibitor (“Formulation 1”). pH 4.1 >>
Succinic acid 0.5 (mass%)
Lactic acid 1
Tranexamic acid 1
Ethanol 5
Glycerin 5
Dipropylene glycol 5
PEG / PPG-14 / 7-dimethyl ether 1
Potassium hydroxide 0.135
Polyoxyethylene phytosterol 2
Glycine 0.1
Ion exchange water

2. Evaluation Test Method [Test (1): Use only Formulation 1]
Four males in their 30s to 40s who are relatively conspicuous with plugs were subjected to a regeneration inhibition test of the plugs. The square plugs were observed by attaching a frame paper to an appropriate area of the top of the nose and observing with a video microscope (VMS, “Keyence VHX-100”). After dropping several drops of adhesive (“Aron Alpha A”; Sankyo) on a slide glass (with matsunami APS coat, s8444), the adhesive application surface side was brought into close contact with the above region. After 10 minutes, the slide glass was slowly peeled off to remove the square plug. The pores from which the horn plugs were completely removed were identified by VMS observation again, and the progress of regeneration of the horn plugs was observed for these identified pores. Here, the progress of regeneration of the horn plug when the preparation was not used (control) was compared with the progress of regeneration of the horn plug when the preparation was continuously applied.

  Formulation 1: Take up 2 ml of cotton (Shiseido Beauty Up Cotton) twice a day and apply to the half face including the top of the nose and cheek, which is the VMS observation site, for 3 weeks.

[Test (2): Combination of skin cleanser and formulation 1]
An experiment in which the test (2) in which the preparation 1 was combined with a skin cleanser was applied in the same manner as in the test (1) was performed by the same four subjects. For the skin cleansing agent, the preparation (1) was applied after the components were sufficiently wiped off.

  In addition, about 1 person among 4 persons, observation by VMS was not implemented but only continuous application | coating was performed.

<Evaluation>
Comparing the growth of square plugs with the same pore over time, when formulation 1 was applied compared to the growth of square plugs without using formulation 1 (in combination with skin cleanser in test (2), the same applies hereinafter) Horn plug growth (= clogged pores) was won, and those with the same growth rate were drawn between the control and the formulation 1 application, and the horn plug in the state where the formulation 1 was not used (control) Compared to the growth, a case where the growth of the horn plug when the formulation 1 was applied (= the pores were clogged) was lost, and a comparison was made for four persons. The results are shown in Table 1.

  The number of pores evaluated in Test (1) and Test (2) is different because the number of pores that can be completely removed and compared can be different depending on the test. A total of 4 subjects, who were 22 wins and 3 losses in the test (1), became 8 wins in 43 wins and 4 losses when combined with cleaning oil in the test (2). Table 2 shows the result of calculating the win-only rate. The rate has increased from 66.7% to 78.2%. 2 and No. The effect was increasing at 3.

  In addition, as a result of the interview (total of 5 subjects) including one subject who did not perform VMS observation of horn plugs, the number of people who could feel that plugging of horn plugs was delayed after 3 weeks was Only 1 out of 5 people was applied. On the other hand, when combined with the cleaning agent, the fact that the plugging of the horn plugs was delayed was realized in 2 people in 1 week out of 5 people, 3 in 2 weeks, and 4 in 3 weeks. It turned out that the feeling increased considerably. Regarding the skin condition, there was a voice that the nose and cheeks were smooth and moisturized on the application side, and the skin condition was also improved.

(Example 2: Screening of horn plug regeneration inhibitor)
Using the horn plug obtained according to the method described in Example 1, screening was performed for the effect of inhibiting horn plug regeneration using the evaluation drugs shown in Table 3 below.

  That is, after dropping several drops of adhesive (“Aron Alpha A”) on the slide glass, the adhesive application surface side was brought into close contact with a partial region of the subject's nasal apex. After 10 minutes, the slide glass was slowly peeled off to obtain a square plug.

The square plug on the slide glass thus obtained was cut out from the adhesive surface with a cutter or the like and adhered onto a double-sided tape laid on the cover glass. It was put into a 5 mL petri dish, and an aqueous solution (1% aqueous solution) containing an evaluation agent shown in Table 3 was added. The change of the horn plug over time was observed with a stereomicroscope and SEM, and its form was evaluated according to the following four steps according to the degree of collapse of the horn plug. In addition, evaluation evaluated comprehensively the evaluation by a stereoscopic microscope method and a SEM method.
(Evaluation criteria)
Rank 0: No change (no change is observed on the surface of the plug)
Rank 1: Some changes are observed (Slight changes are observed, such as the surface of the square plug being slightly blurred)
Rank 2: There is a change (a clear change is observed on the surface of the plug)
Rank 3: There is considerable change (the unevenness change is remarkable, such as the surface of the square plug is broken)
(Evaluation solution)
The evaluation solution used was an aqueous solution containing 1% of the evaluation agent shown in Table 3 (1% by mass-containing aqueous solution).

Below, the formulation example of this invention is shown further.
<Skin Cleansing (Prescription Examples 1-2)>
(Formulation example 1: skin cleansing agent)
(Mixed component) (mass%)
(1) Liquid paraffin 62.0
(2) 2-Ethylhexanoic acid pentaerythritol 10.0
(3) POE (8) oleate (HLB = 9, liquid) 10.0
(4) POE (20) glyceryl triisostearate 10.0
(HLB = 7, liquid)
(5) N, N, N ′, N′-tetrakis (2-hydroxypropyl)
Ethylenediamine 3.0
(6) Purified water 5.0

(Formulation example 2: skin cleansing agent)
(Mixed component) (mass%)
(1) Squalane residue (2) 2-methylhexanoic acid trimethylolpropane 10.0
(3) POE (12) oleate (HLB = 7, liquid) 2.0
(4) POE (20) glyceryl triisostearate 8.0
(HLB = 7, liquid)
(5) POE (50) hydrogenated castor oil monoisostearate 3.0
(HLB = 12, paste)
(6) N, N, N ′, N′-tetrakis (2-hydroxypropyl)
Ethylenediamine 0.1
(7) Vitamin E 0.05
(8) BHT 0.05
(9) Purified water 2
(Manufacturing method)
A room-temperature liquid oil and a surfactant are mixed and stirred at room temperature to be uniform, and then an aqueous component is added and mixed and stirred to prepare a sample.

<Square plug regeneration inhibitor (Prescription Examples 3 to 11)>
(Formulation example 3: lotion)
(Mixed component) (mass%)
A.
Ethanol 5.0
Polyoxyethylene phytosterol 2.0
PPG-13 decyltetradeces-24 0.2
2-Ethylhexyl-P-dimethylaminobenzoate 0.18
Fragrance 0.05
B.
1,3-butylene glycol 9.5
Sodium pyrrolidonecarboxylate 0.5
Xylitol 0.5
Nicotinamide 0.3
Glycerin 5.0
Trimethylglycine 5.0
Tranexamic acid 1.0
Lysine 0.05
Succinic acid 0.5
Purified water residue (production method)
The alcohol phase of A is added to the aqueous phase of B and solubilized to obtain a lotion.

(Formulation Example 4: Emulsion (Pemlan Emulsion System))
(Mixed component) (mass%)
A. Oil phase Dimethylpolysiloxane 0.5
Decamethylcyclopentasiloxane 1
Jojoba oil 0.5
Polyoxyethylene phytosterol 0.2
B. Water phase tranexamic acid 1
Carrot extract 0.5
Alkyl-modified carboxyvinyl polymer 0.05
Carboxyvinyl polymer 0.3
Gum arabic 0.05
Ethyl alcohol 8
Edetate trisodium 0.1
Methylparaben 0.1
Phenoxyethanol 0.2
Citric acid 0.05
Ion exchange water Residual C.I. Neutralization Potassium hydroxide 0.15
(Manufacturing method)
The dissolved (A) phase is added to the dissolved (B) phase, emulsified, and then neutralized with the (C) phase to obtain an emulsion.

(Formulation Example 5: Emulsion)
(Mixed component) (mass%)
(1) Stearic acid 2.0
(2) Lauric acid 0.5
(3) Cetyl alcohol 1.5
(4) Vaseline 5.0
(5) Liquid paraffin 10.0
(6) POE (10 mol) monooleate 2.0
(7) Polyethylene glycol (1500) 3.0
(8) Triethanolamine 1.0
(9) Potassium hydroxide 0.05
(10) Carboxyvinyl polymer 0.05
(11) Sodium bisulfite 0.01
(12) Preservative appropriate amount (13) Fragrance proper amount (14) Citric acid 0.05
(15) 1-piperidinepropionic acid 0.05
(16) Residual ion-exchanged water (Production method)
(10) is dissolved in a part of (16) (A phase). (7), (8), (9), (11), (14), and (15) are added to the remaining (16), and the mixture is kept at 70 ° C. by heating and dissolving (aqueous phase). On the other hand, (1) to (6), (12) and (13) are mixed, heated and melted, and kept at 70 ° C. (oil phase). Preliminarily emulsify by adding an oil phase to the aqueous phase, add phase A, uniformly emulsify with a homomixer, and cool to 30 ° C. while stirring well after emulsification to obtain an emulsion.

(Formulation Example 6: Latex)
(Mixed component) (mass%)
(1) Microcrystalline wax 1.0
(2) Beeswax 2.0
(3) Lanolin 20.0
(4) Liquid paraffin 10.0
(5) Squalane 5.0
(6) Sorbitan sesquioleate ester 4.0
(7) POE (20 mol) sorbitan monooleate 1.0
(8) Lauryl betaine 0.1
(9) Propylene glycol 7.0
(10) L-arginine hydrochloride 5.0
(11) Glycerin 3.0
(12) Glycolic acid 0.05
(13) Sodium bisulfite 0.01
(14) Preservative appropriate amount (15) Fragrance appropriate amount (16) Ion-exchanged water residue (Production method)
Add (8) to (13) to (16) and heat to keep at 70 ° C. (aqueous phase). On the other hand, (1) to (7), (14) and (15) are mixed, heated and melted, and kept at 70 ° C. (oil phase). The water phase is gradually added while stirring the oil phase, and the mixture is uniformly emulsified with a homomixer, and then cooled to 30 ° C. while stirring well to obtain an emulsion.

(Formulation example 7: emulsion (W / O emulsion type))
(Mixed component) (mass%)
(1) Isopropyl alcohol 10.0
(2) Diglyceryl diisostearate 0.5
(3) POE-modified dimethylpolysiloxane 1.0
(4) Polyoxyethylene phytosterol 0.5
(5) Octamethylcyclotetrasiloxane 25.0
(6) Decamethylcyclopentasiloxane 15.0
(7) Trimethylsiloxysilicic acid 5.0
(8) Eucalyptus oil 3.0
(9) Fragrance 0.05
(10) Dipropylene glycol 2.0
(11) Phenoxyethanol 0.3
(12) Trisodium edetate 0.1
(13) Residual ion exchange water (14) Potassium chloride 0.5
(15) Tranexamic acid 0.5
(16) Lactic acid 0.05
(Manufacturing method)
(1) to (9) are dissolved by heating (oil phase), (10) to (16) are dissolved (aqueous phase), the aqueous phase is added to the oil phase and emulsified to obtain an emulsion.

(Prescription Example 8: Jelly)
(Mixed component) (mass%)
(Phase A)
95% ethyl alcohol 10.0
POE (20 mol) octyldodecanol 1.0
Pantothenyl ethyl ether 0.1
Lauryl betaine 0.05
Vitamin E-acetate 0.05
Preservative appropriate amount (phase B)
Potassium hydroxide 0.1
(Phase C)
Glycerin 5.0
Dipropylene glycol 10.0
Sodium bisulfite 0.03
Citric acid 0.05
L-arginine magnesium salt 0.05
Carboxyvinyl polymer 0.2
Residual ion exchange water
A phase and C phase are uniformly dissolved, and A phase is added to C phase to solubilize. Then, after adding phase B, filling is performed to obtain a jelly.

(Formulation example 9: O / W cream)
(Mixed component) (mass%)
A. Oil phase Cetanol 4.0
Vaseline 7.0
Isopropyl myristate 8.0
Squalane 15.0
Stearic acid monoglycerol ester 2.2
POE (20) sorbitan monostearate 2.8
Lauryl betaine 0.05
5-Ethoxysalicylic acid 0.01
Vitamin E Nicotinate 2.0
Fragrance 0.3
Antioxidant appropriate amount Preservative appropriate amount Aqueous phase Glycerin 10.0
Sodium hyaluronate 0.02
Xylitol 1.0
Dipropylene glycol 4.0
PEG / PPG-14 / 7 dimethyl ether 1.0
Alanine 3.0
Edetate disodium 0.01
Citric acid 1.0
Purified water residue (production method)
A (oil phase) and B (aqueous phase) were each heated to 70 ° C. and completely dissolved. Next, A was added to B and emulsified with an emulsifier. Furthermore, the emulsion is cooled using a heat exchanger,
Get a cream.

(Formulation example 10: W / O cream)
(Mixed component) (mass%)
(1) Hectorite treated with dimethyl distearyl ammonium chloride 2.0
(2) Polyoxyethylene / methylpolysiloxane polymer 0.1
(3) Lauryl betaine 0.5
(4) Liquid paraffin 10.0
(5) Vaseline 5.0
(6) Cetyl octoate 20.0
(7) Sodium L-glutamate 0.01
(8) Dipropylene glycol 5.0
(9) Methylparaben 0.2
(10) Salicylic acid 1.0
(11) Xylitol 2.0
(12) Remaining amount of ion-exchanged water (production method)
(2) After the temperature of (3), (4) and (6) is raised to 50 ° C., (1) is added to the oil phase part completely dissolved by adding (5) and dispersed uniformly. 12) To (7) (8) (9) (10) (11) dissolved in water phase parts are heated to 50 ° C. and added, uniformly dispersed in HM, cooled to room temperature, W / O cream is obtained.

(Prescription Example 11: Cloudy lotion)
(Mixed component) (mass%)
(1) α-olefin oligomer 2.0
(2) Isostearyl alcohol 0.5
(3) Isostearic acid 0.8
(4) Sorbitan sesquiisostearate 0.1
(5) POE (14) / POP (7) dimethyl ether 1.0
(6) Polyoxyethylene phytosterol 1.0
(7) DL-α-tocopherol acetate 0.05
(8) Perfume appropriate amount (9) 1,3-butylene glycol 5.0
(10) Ethanol 5.0
(11) Xanthan gum 0.1
(12) Succinic acid 0.5
(13) Dipropylene glycol 5.0
(14) Tranexamic acid 1.0
(15) Sodium hyaluronate 0.01
(16) Sodium pyrosulfite 0.005
(17) Phenoxyethanol 0.5
(18) Sodium metaphosphate 0.05
(19) Lauryldimethylaminoacetic acid betaine 0.2
(20) Potassium hydroxide 0.2
(21) Lactic acid 1.0
(22) Concentrated glycerin 5.0
(23) Remaining amount of purified water (production method)
(1) to (8) are heated and dissolved at 70 ° C., stirred and mixed, and while stirring while maintaining the temperature at 70 ° C., (23) is gradually added to emulsify, and oil-in-water emulsification A composition is obtained. The obtained oil-in-water emulsion composition is further added to an aqueous formulation containing (9) to (22), and uniformly dispersed by stirring to obtain a cloudy lotion.

INDUSTRIAL APPLICABILITY According to the present invention, there are provided a horn plug regeneration suppression method and a horn plug regeneration suppression kit that exhibit an extremely high effect of suppressing horn plug regeneration.

Claims (5)

  One or two selected from lactic acid, succinic acid, citric acid, malic acid, salicylic acid, pyrrolidone carboxylic acid, glycolic acid, and salts thereof after applying the skin cleanser containing polyoxyethylene fatty acid ester to the skin A method for inhibiting the regeneration of horn plugs, which comprises applying to the skin a horn plug regeneration inhibitor containing more than one species.   One or two selected from fatty acid soaps, higher alkyl sulfates, N-acyl glutamates, N-acyl lower alkyl taurates, betaine surfactants, and polyoxyalkylene phytosterols in the horn plug inhibitor The method of inhibiting horn plug regeneration according to claim 1, comprising at least one kind of surfactant.   The method of inhibiting horn plug regeneration according to claim 1 or 2, further comprising an anti-skin roughening agent in the horn plug inhibitor.   The method for inhibiting horn plug regeneration according to claim 3, wherein the anti-skin roughening agent is one or more selected from polyoxyethylene / polyoxypropylene / dimethyl ether, tranexamic acid, and pantothenyl ethyl ether.   A horn plug regeneration suppression kit comprising the skin cleansing material according to any one of claims 1 to 4 and a horn plug regeneration inhibitor.