JP2012130537A - Dose package and dose package system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a highly economical and convenient dose package and dose package system.SOLUTION: A microcontroller 41 determines in a step S4 whether an unsealing signal is input or not. The unsealing signal is generated by unsealing a medicine containing cell 13 (i.e. by cutting and peeling off an unsealing tub 21) thereby cutting a plus wire 25 to increase resistance between the plus wire 25 and an earth wire 26. When a patient or a subject unseals the medicine containing cell 13 and the determination in the step S4 is Yes, the microcontroller 41 compares in a step S6 the taking-scheduled medicine of a medicine taking schedule with the unsealing signal to determine whether the unsealed medicine containing cell 13 is right or not (whether the unsealing is rightly done or not). When the determination is Yes, the microcontroller 41 records medicine taking data (taking medicine and medicine taking time) into a RAM 47 in a step S7.

Description

  The present invention relates to a dose package that contains a medicine used for home medical care and clinical trials, and a dose package system using the dose package.

  In home medical care, there is a demand for prevention of forgetting to drink drugs and mistakes in drinking for elderly patients taking various drugs and cancer patients taking difficult-to-drink anticancer drugs. In clinical trials such as clinical trials, medical institutions and pharmaceutical companies need to construct a highly accurate medication database by recording the exact time when a subject took a drug. Therefore, an optical sensor for storing medicines (tablets and capsules) corresponding to the designated medication times in a plurality of medicine storage cells (chambers) having an openable / closable upper lid, respectively, and detecting opening of the upper lid and taking out of the medicines There has been proposed a resin-molded medicine container (dose package) that includes a memory and detects a medicine taken by a patient or a subject and a medication time by an optical sensor and records it in the memory (see Patent Document 1).

JP 2002-291844 A

  However, the dose package of Patent Document 1 is transparent in order to detect the opening of the upper lid or the like by the optical sensor, because the optical sensor and the wiring are provided for each medicine-containing cell, the structure becomes complicated and the manufacturing cost increases. Can not be used (that is, the drug in the drug storage cell cannot be confirmed from the outside), it is difficult to carry out reliable hygiene management on the premise that it is reused. There is a problem that the weight must be increased because the resin is used as a material.

  The present invention has been made in view of such a background, and an object thereof is to provide a dose package and a dose package system that are excellent in economy, convenience, and the like.

  In the dose package according to the first aspect of the present invention, a package main body formed with a plurality of drug containing cells having openings used for loading and unloading of the drug, and the drug containing cell fixed to the package main body. A dose package including a cover sheet for sealing an opening, wherein the cover sheet is provided corresponding to each of the drug containing cells, and an opening portion that can be opened for each drug containing cell; A conductor that is provided corresponding to each of the opening portions and intersects with an outline of the opening portion, and one end of each of the conductors is disposed on an electrode portion formed on the package body or the cover sheet. Is done.

  In the dose package according to the second aspect of the present invention, the cover sheet is made of paper or a resin film, and the conductor is a conductive ink printed on the cover sheet.

  Moreover, in the dose package which concerns on the 3rd side surface of this invention, a perforation is formed in the outline of the said opening part.

  Further, in the dose package system according to the fourth aspect of the present invention, the dose package according to the first to third inventions and the electrode part of the dose package are detachably mounted and based on the conductive state of the conductor. And a memory device that detects opening of the cover sheet for each medicine-containing cell and stores the detection result as medication data together with time.

  Further, in the dose package system according to the fifth aspect of the present invention, the memory device includes a scheduled medication time storage unit for storing a scheduled medication time of a medicine stored in a predetermined medicine storage cell, and a scheduled medication time. Medication alarm means for generating at least one of an audible medication alarm and a visual medication alarm.

  Further, in the dose package system according to the sixth aspect of the present invention, if the medicine storage cell is not opened even after a predetermined time has elapsed from the scheduled medication time, an audible forgetting alarm and a visual forgetting medication A medication forgetting alarm means for issuing at least one of alarms is provided.

  Further, in the dose package system according to the seventh aspect of the present invention, when an unsealing part corresponding to a different medicine containing cell is unsealed at the scheduled medication time, an audio misopening alarm and a visual misopening alarm are provided. A false-open alarm means for emitting at least one of them is provided.

  In the dose package system according to the eighth aspect of the present invention, the memory device transmits the medication data to the outside by wireless communication or wired communication.

  In the dose package system according to the ninth aspect of the present invention, the scheduled medication time in the memory device can be changed from the outside by wireless communication or wired communication.

  According to the first aspect of the present invention, when the opening tab is peeled off to open the drug containing cell, the conductor breaks, thereby detecting which drug containing cell is opened. As compared with the apparatus, the structure can be simplified and the manufacturing cost can be reduced. Further, according to the second aspect, the dose package can be further reduced in cost and weight, and mass productivity can be improved. Moreover, according to the 3rd side surface, by opening along a perforation, an opening part can be opened easily and a conductor is also fractured | ruptured reliably. According to the fourth aspect, the medication data is automatically stored in the memory device without the patient or subject taking notes, and the used dose package can be removed from the memory device and discarded. Further, according to the fifth aspect, the patient or subject is prompted by the medication alarm, so that the medication can be easily taken at the scheduled medication time. Moreover, according to the 6th side surface, it becomes easy to notice that the patient and the test subject have forgotten to take the medicine by being alerted by the medicine forgetting to take medicine. Moreover, according to the 7th side surface, it becomes difficult to take an incorrect chemical | medical agent by a patient and a test subject being alerted by the misopening alarm. Further, according to the eighth aspect, it becomes easier for medical institutions and pharmaceutical companies to obtain medication data. Moreover, according to the 9th side, it becomes easy for a medical institution or a pharmaceutical company to change a medication schedule.

It is a perspective view of a dose package system concerning an embodiment concerning an embodiment. It is a disassembled perspective view of the dose package which concerns on embodiment. It is a reverse view of the cover sheet which concerns on embodiment. It is a disassembled perspective view of the memory unit which concerns on embodiment. It is a block diagram which shows the apparatus structure of the unit main body which concerns on embodiment. It is a flowchart which shows the procedure of the medication assistance control which concerns on embodiment.

Hereinafter, an embodiment of a dose package system according to the present invention will be described in detail with reference to the drawings.
<< Configuration of Embodiment >>
<Doze Package System>
As shown in FIG. 1, a dose package system 1 includes a dose package 2 that is used for containing a medicine, a memory unit 3 that is attached / integrated to the dose package 2, and wireless communication using infrared rays between the memory unit 3. A transmission / reception unit 4 that performs communication and a personal computer (hereinafter referred to as a PC) 5 that performs wired (cable or the like) communication between the transmission / reception unit 4 are configured. The PC 5 performs wired (LAN or Internet) communication with an external personal computer (not shown) (hereinafter referred to as an external PC) installed in a medical institution or pharmaceutical company. In the description of each member, the top, bottom, left and right, front and back are indicated by arrows in FIG. 1, and the position and direction are indicated accordingly.

<Doze Package>
As shown in FIG. 2, the dose package 2 includes a package body 11 of a vacuum molded product (or a compressed air molded product) made of a transparent resin such as polyethylene and a cover sheet 12 of a punched product made of glassine paper. It is made up of.

  On the back surface of the package body 11, a plurality of (in this embodiment, 7 vertically, 4 horizontally, 28 in total) drug storage cells 13 are protruded, and these drug storage cells 13 are four times a day. A drug (capsule or tablet) 14 for one week is accommodated. A rectangular electrode protection tab 15 that is long in the vertical direction is defined at the left end of the package body 11, and this electrode protection tab 15 can be removed along the perforation 16. Note that an adhesive material 17 is applied to the surface of the package body 11 in an appropriate place, and the cover sheet 12 can be adhered to the package body 11 after the medicine 14 is stored in the medicine storage cell 13.

  On the surface of the cover sheet 12, opening tabs 21 corresponding to the respective drug containing cells 13 are arranged, and the opening tabs 21 can be cut off along the perforations 22 formed in the contours thereof. Each opening tab 21 is printed with symbols 23a to 23d indicating the timing of medication taking (morning, noon, evening, before going to bed) in one column on the left and right, and up and down on seven rows, and on the left of the leftmost symbol 23a An entry field 24 for writing (or date) is provided. In addition, you may attach | subject a number and a symbol (1-28, A1-F4 etc.) to the opening tab 21 instead of the symbols 23a-23d.

  On the other hand, as shown in FIG. 3, on the back surface of the cover sheet 12, a plus wire 25 that horizontally crosses each unsealing tab 21 and a common ground wire (common wire) 26 to which each plus wire 25 is connected are arranged. On the left end side, a package side electrode portion 27 where the end portions (electrode terminals) 25a and 26a of the plus wire 25 and the ground wire 26 are gathered is installed. In the present embodiment, the plus line 25 and the ground line 26 are formed by printing using conductive ink. A positioning hole 28 into which a positioning pin 33 (see FIG. 4) to be described later is fitted is formed above and below the package-side electrode portion 27, respectively, and a disposal perforation 29 is formed from the positioning hole 28 toward the side edge. Is provided. The perforation 22 is formed by a half cut that cuts only on the surface side so as not to hinder printing with the conductive ink (so that the plus wire 25 and the ground wire 26 are not broken). .

<Memory unit>
As shown in FIG. 4, the memory unit 3 protrudes from the unit main body 31 attached to the back surface of the cover sheet 12, the unit cover 32 that holds the cover sheet 12 together with the unit main body 31, and the back surface of the unit cover 32. The resin nut 34 is engaged with a pair of upper and lower positioning pins 33. On the surface of the unit main body 31, a unit side electrode portion 36 is formed by arranging a plurality of electrode terminals 35 corresponding to the electrode terminals 25 a and 26 a of the package side electrode portion 27, and the unit main body 31 is formed in the dose package 2. When attached, the electrode terminals 25a and 26a of the package side electrode part 27 and the electrode terminal 35 of the unit side electrode part 36 are crimped. Positioning holes 37 into which the positioning pins 33 are fitted are formed above and below the unit-side electrode portion 36, respectively.

  As shown in FIG. 5, the unit main body 31 includes a microcontroller 41, a real time clock 42, an audio controller 43, a speaker 44, a warning lamp 45, a stop switch 46, and a random access memory (hereinafter referred to as RAM). ) 47, an infrared LED 48, and an infrared light receiving element 49. The microcontroller 41 is an integrated circuit serving as a control center. The microcontroller 41 is connected to the electrode terminal 35 of the unit-side electrode unit 36 and transmits / receives electric signals to / from other components of the unit main body 31.

  The real time clock 42 is operated by a battery independent from the microcontroller 41 and the like, and always outputs a time signal to the microcontroller 41. The voice controller 43 causes the speaker 44 to output a synthesized voice or a warning sound based on a command from the microcontroller 41. The warning lamp 45 emits light with a predetermined light emission pattern based on a command from the microcontroller 41. The stop switch 46 outputs a warning stop command to the microcontroller 41 based on an external (user) input. The RAM 47 stores the scheduled medication and the scheduled medication time input from the PC 5 and the like, and stores the medication data based on the detection signal from the electrode terminal 35 and the time information from the real-time clock 42. The infrared LED 48 outputs an infrared signal to the infrared light receiving unit 51 (see FIG. 1) of the transmission / reception unit 4 based on an output command from the microcontroller 41. The infrared light receiving element 49 receives the infrared signal output from the infrared LED 52 (see FIG. 1) of the transmission / reception unit 4 and outputs the reception result to the microcontroller 41.

<< Operation of Embodiment >>
<Dose package and memory unit set>
In a medical institution or pharmaceutical company, when a doctor sets the type and amount of a medicine according to a patient or subject, the pharmacist puts the medicine 14 as set into each medicine containing cell 13 of the package body 11. Next, the pharmacist puts the cover sheet 12 on the surface of the package body 11 and adheres / integrates the package body 11 and the cover sheet 12 to complete the setting of the dose package 2.

  Next, the pharmacist stores the scheduled time for taking each medicine 14 (that is, the scheduled opening time for each medicine storage cell 13) as a medication schedule in the unit main body 31 of the memory unit 3 by infrared communication from an external PC or the like. After that, the electrode protection tab 15 of the package body 11 is removed to expose the package side electrode portion 27. Next, the pharmacist inserts the positioning pin 33 into the positioning hole 28, holds the cover sheet 12 between the unit main body 31 and the unit cover 32 of the memory unit 3, and then engages the resin nut 34 with the positioning pin 33. . As a result, the memory unit 3 is integrated with the dose package 2, and at the same time, the package-side electrode portion 27 and the unit-side electrode portion 36 are pressure-bonded.

<Medication support control>
The patient or subject takes the dose package 2 in which the memory unit 3 is integrated from the pharmacy to the home (or ward bed), and places it next to the transmission / reception unit 4 (in the range where infrared rays can reach). The microcontroller 41 repeatedly executes the medication support control whose procedure is shown in the flowchart of FIG. 6 at a predetermined processing interval (for example, 1 sec) from when the memory unit 3 is integrated with the dose package 2. When the medication support control is started, the microcontroller 41 determines whether or not the scheduled medication time has come based on the medication schedule and the real time clock 42 in step S1 of FIG. 6, and if this determination is No, performs any processing. Return to the start.

  If the determination in step S1 is Yes, the microcontroller 41 executes a medication alarm in step S2. The medication alarm according to the present embodiment includes an auditory medication alarm and a visual medication alarm. The medication storage cell 13 to be opened is voiced from the speaker 44 (for example, “Monday, evening medication time has come”, “3 And the like, and the warning lamp 45 is turned on simultaneously. In addition, as a medication alarm, an instruction lamp may be installed on the top of each medicine storage cell 13 and the corresponding instruction lamp may be blinked. In addition, the medication alarm may be repeated at a predetermined time interval (for example, 15 seconds). When the patient or subject misses the auditory medication alarm, the medication medication alarm is given each time the stop switch 46 is pressed. The alarm may be repeated.

  Next, the microcontroller 41 starts a countdown timer Tcd having a predetermined value (for example, 5 min) in step S3, and then determines whether an opening signal is input in step S4. The opening signal is generated when the medicine containing cell 13 is opened (that is, when the opening tab 21 is cut off), the plus wire 25 is cut, and the resistance (electrode terminal 25a) between the plus wire 25 and the ground wire 26 is cut. , 26a) is increased. As a matter of course, an opening signal corresponding to each opening tab 21 is generated so that it can be recognized which opening tab 21 has been cut off. Since the first determination in step S4 is normally No, the microcontroller 41 determines whether or not the value of the countdown timer Tcd is 0 in step S5. While this determination is No, the microcontroller 41 determines in step S4. repeat.

  When the patient or subject opens the medicine storage cell 13 and the determination in step S4 is Yes, the microcontroller 41 compares the medicine scheduled to be taken in the medication schedule with the opening signal in step S6, thereby opening the medicine opened. It is determined whether or not the accommodation cell 13 is correct (whether or not the opening has been properly performed). If the determination in step S6 is Yes, the microcontroller 41 records the medication data (medication medication and medication time) in the RAM 47 in step S7.

(Forgetting to take medication)
When the determination in step S5 is Yes (when the value of the countdown timer Tcd becomes 0, if the patient or subject does not open the medicine containing cell 13), the microcontroller 41 executes a medication forgetting alarm in step S8. To do. The missed medication alarm of this embodiment comprises an audible medication forgotten alarm and a visual medication forgotten alarm, and a sound from the speaker 44 (for example, “I forgot to take medication”) and a warning lamp 45 blinking. Do it at the same time. Note that the warning lamp 45 in the medication forgotten alarm may change the luminescent color (for example, from blue to red) or increase the intensity of the medication alarm.

  Next, the microcontroller 41 determines whether or not a stop signal is input in step S9 (whether or not the patient or the subject has pressed the stop switch 46). . If the patient or subject stops taking the drug for some reason (for example, vomiting feeling) and the determination in step S9 is Yes, the microcontroller 41 stops the forgetting to take alarm in step S10, and in step S7. Medication data (in this case, no medication was performed) is recorded in the RAM 47.

(Misopened)
If the patient or subject opens the wrong medicine storage cell 13 and the determination in step S6 is No, the microcontroller 41 executes an erroneous opening alarm in step S11. The false-open alarm of the present embodiment includes an auditory false-open alarm and a visual false-open alarm, and the sound from the speaker 44 (for example, “Drugs are wrong”) and the warning lamp 45 blink simultaneously. Do.

  Next, the microcontroller 41 determines whether or not a stop signal is input in step S12 (whether or not the patient or subject has pressed the stop switch 46), and if this determination is No, continues the false-open alarm. . If the patient or subject recognizes the erroneous opening and presses the stop switch 46, and the determination in step S12 is Yes, the microcontroller 41 stops the erroneous opening alarm in step S13, and then proceeds to step S4. The above-described series of processing is performed. In addition, since the plus line 25 is cut in the unsealed opening tab 21, even if a medication alarm based on the medication schedule is executed for the medicine containing cell 13, an unsealing signal is generated by opening the opening tab 21. No longer. Therefore, when the patient or subject takes the medicine 14 in the corresponding medicine storage cell 13 in response to the medication alarm after performing the erroneous opening, it is necessary to notify the medical institution or pharmaceutical company of that fact.

(Confirm medication time)
When the patient or subject wants to check the next medication time, he or she presses the stop switch 46. Then, the microcontroller 41 informs the patient and the subject of the medication time by voice from the speaker 44 (for example, “the next medication time is 6 pm”).

(Abnormal warning)
The microcontroller 41 always detects whether or not each electrode terminal 35 or component in the memory unit 3 is abnormal (contact failure or the like). If there is an abnormality, the sound from the speaker 44 (for example, , “An abnormality has occurred. Please contact the pharmacy”) to inform the patient or subject of the abnormality.

(Dose package disposal)
When all the medicines 14 contained in the dose package 2 are taken, the patient or the subject separates the memory unit 3 from the dose package 2. At this time, if a force for pulling the memory unit 3 straight to the dose package 2 is applied, the positioning pins 33 tear the perforation 29 for disposal, and the dose package 2 and the memory unit 3 are easily separated. Thereby, the patient or the subject can recycle the memory unit 3 by discarding the bulky dose package 2 and then returning only the memory unit 3 to the pharmacy of the medical institution or pharmaceutical company.

<Communication between memory unit and transceiver unit>
The memory unit 3 transmits the medication data to the transmission / reception unit 4 at a predetermined transmission timing (for example, when the medication data is updated). The transmission / reception unit 4 transmits the medication data to the external PC via the PC 5 in real time. Thereby, a medical institution or a pharmaceutical company allows a doctor to grasp a patient's medication situation and a researcher to construct a medication database. The transmission from the memory unit 3 to the transmission / reception unit 4 may be performed based on a command from the PC 5 or the external PC 5.

  On the other hand, when it becomes necessary to change the medication schedule (when taking medication) for some reason, the medical institution or the pharmaceutical company sends the update information from the PC 5 or the external PC 5 to the memory unit 3 via the transmission / reception unit 4, You can change your medication schedule.

  Although description of specific embodiment is finished above, the aspect of the present invention is not limited to this embodiment. For example, in the above-described embodiment, wireless communication using infrared rays is performed between the memory unit and the transmission / reception unit. However, wireless communication using radio waves may be performed, or wired communication using a connector or the like may be performed. You may make it let. In the above embodiment, the memory unit performs communication with a PC or an external PC via the transmission / reception unit. However, such communication is not essential, and a dose package in which the memory unit is integrated is provided. You may make it return to a medical institution or a pharmaceutical company only for a memory unit (or a dose package and a memory unit) after completion of a medication after giving to a patient or a test subject. In this case, a medical institution or a pharmaceutical company can download medication data stored in the memory unit to a PC to manage medication and construct a medication database.

  On the other hand, in the above embodiment, the plus wire or the ground wire printed on the cover sheet with the conductive ink is used as the conductor, but a copper wire, copper foil, or the like may be used as the conductor. In the above embodiment, the positioning pins are formed on the unit cover, and the unit main body and the unit cover are fastened with the resin nut. However, the elastic locking claw can be provided at the tip of the positioning pin to be fastened with one touch. You may do it. Further, in the above embodiment, the memory unit is configured by the unit main body and the unit cover, and the dose package is sandwiched between the unit main body and the unit cover. However, the dose package is inserted into the slit provided in the memory unit. You may take a method. In addition, within the scope not departing from the gist of the present invention, the specific shape of the dose package, the specific configuration of the memory unit, the specific procedure of the medication support control, and the like can be appropriately changed.

1 Dosage Package System 2 Dosage Package 3 Memory Unit (Memory Device)
4 Transmission / Reception Unit 5 External Personal Computer 11 Package Body 12 Cover Sheet 13 Drug Storage Cell 14 Drug 21 Opening Tab (Opening Portion)
22 perforation 25 plus wire (conductor)
27 Package side electrode part (electrode part)
31 Unit body 41 Microcontroller 42 Real-time clock 43 Audio controller 44 Speaker (alarm means)
45 Warning lamp (alarm means)
46 Stop switch 47 Random access memory (RAM)
48 Infrared LED
49 Infrared detector

Claims (9)

A dose package comprising: a package main body formed with a plurality of drug containing cells having openings for loading and unloading of a drug; and a cover sheet that is fixed to the package main body and seals the openings of the drug containing cells. Because
The cover sheet is
Provided corresponding to each of the drug containing cells, and can be opened for each drug containing cell;
Provided corresponding to each of the opening parts, and having a conductor intersecting with the outline of the opening part,
One end of each conductor is disposed on an electrode part formed on the package body or the cover sheet.   The dose package device according to claim 1, wherein the cover sheet is made of paper or a resin film, and the conductor is a conductive ink printed on the cover sheet.   The dose package apparatus according to claim 1, wherein perforations are formed in an outline of the opening portion. The dose package according to any one of claims 1 to 3,
A memory that is detachably attached to the electrode portion of the dose package, detects opening of the cover sheet for each drug-containing cell based on the conductive state of the conductor, and stores the detection result as medication data along with time A dose package system comprising: a device.   The memory device stores a scheduled medication time storage unit that stores a scheduled medication time of a medicine accommodated in a prescribed medication storage cell, and a medication that emits at least one of an auditory medication alarm and a visual medication alarm at the scheduled medication time. The dose package system according to claim 4, further comprising alarm means.   When the medicine storage cell is not opened even after a predetermined time has elapsed from the scheduled medication time, it is provided with a medication forgotten alarm means for issuing at least one of an audible medication forgotten alarm and a visual medication forgotten alarm. The dose package system according to claim 5.   When the opening corresponding to the medicine storage cell different at the scheduled medication time is opened, it is provided with an erroneous opening alarm means for emitting at least one of an auditory erroneous opening alarm and a visual erroneous opening alarm, The dose package system according to claim 5 or 6.   The dose package system according to any one of claims 5 to 7, wherein the memory device transmits the medication data to the outside by wireless communication or wired communication.   The dose package system according to any one of claims 5 to 8, wherein the scheduled medication time in the memory device can be changed from outside by wireless communication or wired communication.

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