JP2012152441A - Microscope for intraocular observation and filter unit - Google Patents

Abstract

By optimizing an optical system used for intraocular observation, visibility when observing a fundus tissue is improved and a stained region of an inner boundary membrane is clarified.
An intraocular observation microscope having an observation optical system for observing the inside of an eye irradiated with illumination light while using an eyeball as an object to be observed, and a filter attached to a lower end of a lens barrel A unit 15 is provided. The filter unit 15 includes a polarizing filter 33, a blue enhancement filter 34, and a blue light cut filter 35, and is configured to be able to observe the inside of the eye by selectively using these optical filters.
[Selection] Figure 2

Description

  The present invention relates to an intraocular observation microscope used for observing the inside of an eyeball (hereinafter referred to as “intraocular”) and a filter unit suitable for use therein.

  In ophthalmic surgery or the like, an intraocular observation microscope is used. For example, when performing vitreous surgery, a contact lens is placed on the cornea of the eyeball that is the object of observation, and the surgeon (ophthalmologist) observes the inside of the eye with the intraocular observation microscope through this contact lens. We are taking action. As an intraocular observation microscope, for example, the microscope described in Patent Document 1 is known.

  One example of vitreous surgery is macular hole surgery. This operation is roughly divided into three stages. In the first stage, the vitreous body is removed with a vitreous cutter. In the second stage, the inner boundary membrane around the macula (thin membrane on the retina surface) is removed. In the third stage, gas is injected into the eye. Of these, in the second and third stages, the surgeon performs a precise intraocular operation using a surgical instrument. At this time, it is required to secure a good observation system.

Japanese Patent Laying-Open No. 2005-230558

  However, the inner boundary membrane that is peeled off in the operation of the macular hole is a thin transparent membrane structure of 3.5 μm or less, and is therefore very difficult to visually recognize. At present, the inner boundary film to be peeled is indocyanine green (hereinafter referred to as “ICG”), trypan blue (hereinafter referred to as “TB”), brilliant blue G (hereinafter referred to as “BBG”). Intraocular tissue staining liquid (hereinafter also simply referred to as “staining liquid”). When the inner boundary membrane is stained with a staining solution, a difference occurs in the hue between the actually stained region (hereinafter referred to as “stained region”) and the surrounding membrane tissue. For this reason, the visibility of the inner boundary film is higher after dyeing than before dyeing.

  Recently, however, further improvement in the visibility of the stained region of the inner boundary membrane has been demanded from the field of ophthalmic medicine. The reason for this is that ensuring good visibility during ophthalmic surgery is regarded as very important in performing safe surgery. In particular, in the case of macular hole surgery, since a relatively high technique and proficiency are required to peel the inner boundary membrane, improvement in visibility is strongly desired. In response to such a demand, for example, when the concentration of the staining solution is increased, the visibility is improved, but the risk of causing tissue damage to the retina is increased. For this reason, there is a limit to increasing the concentration of the staining solution.

  Therefore, the present inventor has repeatedly studied the optical system and the like of the intraocular observation microscope in order to improve the visibility in the intraocular observation. Therefore, when observing the inside of the eye (in particular, the fundus) using an intraocular observation microscope, it has been found that combining specific optical filters is effective for improving the visibility.

  The main object of the present invention is to improve the visibility when observing the fundus tissue by optimizing the optical system used for intraocular observation, and to clarify the staining area of the inner boundary membrane. is there.

The first aspect of the present invention is:
With an observation optical system for observing the inside of the eye irradiated with illumination light while making the eyeball an object to be observed,
The observation optical system includes a blue enhancement filter and a polarization filter disposed on the object side of the blue enhancement filter, and the inside of the eye can be observed through the blue enhancement filter and the polarization filter. And an intraocular observation microscope.

The second aspect of the present invention is:
With an observation optical system for observing the inside of the eye irradiated with illumination light while making the eyeball an object to be observed,
The observation optical system includes a blue light cut filter and a polarization filter disposed closer to the object side than the blue light cut filter, and can observe the inside of the eye through the blue light cut filter and the polarization filter. This is an intraocular observation microscope.

The third aspect of the present invention is:
With an observation optical system for observing the inside of the eye irradiated with illumination light while making the eyeball an object to be observed,
The observation optical system has a plurality of optical filters including at least one of a blue enhancement filter and a blue light cut filter and a polarizing filter, and the inside of the eye can be observed selectively using the plurality of optical filters. An intraocular observation microscope characterized by comprising a filter unit.

The fourth aspect of the present invention is:
A filter unit that is used by being mounted on an intraocular observation microscope equipped with an observation optical system for observing the inside of an eye irradiated with illumination light while using an eyeball as an object to be observed.
It has a plurality of optical filters including at least one of a blue enhancement filter and a blue light cut filter and a polarizing filter, and the inside of the eye can be observed by selectively using the plurality of optical filters. This is a filter unit.

A fifth aspect of the present invention is the filter unit according to the fourth aspect,
The plurality of optical filters include the blue enhancement filter, the blue light cut filter, and the polarization filter,
First support means for supporting the blue enhancement filter so as to be movable back and forth with respect to the position of the optical axis of the observation optical system;
Second support means for supporting the blue light cut filter so as to be movable back and forth with respect to the position of the optical axis of the observation optical system;
And third support means for supporting the polarizing filter so as to be movable back and forth with respect to the position of the optical axis of the observation optical system.

  According to the present invention, by optimizing the optical system used for intraocular observation, the visibility when observing the fundus tissue can be improved, and the stained region of the inner boundary membrane can be clarified.

It is a functional block diagram which shows the structural example of the microscope for intraocular observation which concerns on embodiment of this invention. It is an enlarged view (the 1) which shows the attachment state of the filter unit in the microscope for intraocular observation. It is a perspective view (the 1) which shows the whole structure of a filter unit. It is a perspective view (the 2) which shows the whole structure of a filter unit. It is an enlarged view (the 2) which shows the attachment state of the filter unit in the microscope for intraocular observation. It is a figure which shows the spectral irradiance distribution graph obtained when applying the intraocular illumination light by a halogen light source and irradiating the fundus of a pig eye. It is a figure which shows the spectral irradiance distribution graph obtained when 420-nm intraocular illumination light by a xenon light source is applied and the fundus of a pig eye is irradiated. It is a figure which shows the spectral irradiance distribution graph obtained when applying the intraocular illumination light of 515 nm by a xenon light source and irradiating the fundus of a pig eye.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
In the embodiment of the present invention, description will be given in the following order.
1. 1. Configuration of the intraocular observation microscope 2. Configuration of filter unit 3. Operation of filter unit 4. How to use an intraocular microscope Measurement result 6. Modified example

<1. Configuration of microscope for intraocular observation>
FIG. 1 is a functional block diagram showing a configuration example of an intraocular observation microscope according to an embodiment of the present invention. The intraocular observation microscope 1 is, for example, a binocular optical microscope, and is largely configured to include an illumination optical system 2 and an observation optical system 3. The intraocular observation microscope 1 is mainly used in ophthalmic surgery, but is not particularly limited thereto, and can be widely used for intraocular observation.

  The illumination optical system 2 is an optical system that irradiates light into the eye. The illumination optical system 2 includes a light source 4, a condenser lens 5, a diaphragm member 6, and a prism 7. The observation optical system 3 is an optical system for observing the inside of the eye. The observation optical system 3 includes an eyepiece lens 11, a zoom lens 12, a beam splitter 13, an objective lens 14, and a filter unit 15.

  In addition, about the structure of each optical system of the illumination optical system 2 and the observation optical system 3, not only the structure mentioned here but various changes (addition, a change, replacement, deletion, etc. of an optical element) are possible.

  The light source 4 is a light source provided in the intraocular observation microscope 1 itself, and generates illumination light. The condensing lens 5 condenses the illumination light generated by the light source 4. The aperture member 6 has an aperture opening that allows the illumination light condensed by the condenser lens 5 to pass therethrough. The prism 7 reflects the illumination light that has passed through the aperture opening of the aperture member 6 toward the eyeball that is the object to be observed.

  The eyepiece 11 is disposed in the vicinity of the eyepiece on the optical axis of the light reflected from the eyeball. The eyepiece is a portion that the operator looks into when observing the inside of the eye. The eyepieces are arranged in a pair on the left and right at the top of a lens barrel (described later) that constitutes the main body of the intraocular observation microscope 1. The zoom lens 12 is configured by combining a plurality of lenses (convex lens, concave lens). The beam splitter 13 divides the light incident through the objective lens 14. The light split by the beam splitter 13 travels toward the corresponding eyepiece. The objective lens 14 is disposed at the lowermost part of the lens barrel. The filter unit 15 will be described in detail below.

<2. Configuration of filter unit>
FIG. 2 is an enlarged view showing a mounting state of the filter unit in the intraocular observation microscope. 3 and 4 are perspective views showing the overall structure of the filter unit. In FIGS. 3 and 4, the optical filter described later is omitted.

  The filter unit 15 is attached to the lower end of the lens barrel 16 of the intraocular observation microscope 1. The objective lens 14 described above protrudes from the lower end portion of the lens barrel 16. The filter unit 15 is attached to the lower end portion of the lens barrel 16 while avoiding positional interference with the objective lens 14.

  The filter unit 15 includes a base member 21, a shaft receiving member 22, three pairs of guide shafts 23, a shaft support member 24, two arm members 25 and 26, and three pairs of slide members 27, 28, and 29. The configuration includes three filter holders 30, 31, 32, a polarizing filter 33, a blue enhancement filter 34, and a blue light cut filter 35.

  The base member 21 is a member serving as a base for fixing the filter unit 15 to the lens barrel 16. The base member 21 is configured by, for example, a rectangular metal plate. A total of four mounting holes 36 are provided in the base member 21. Each mounting hole 36 is formed so as to penetrate the base member 21. At the lower end portion of the lens barrel 16, four mounting screw holes (not shown) corresponding to the mounting holes 36 are formed. For example, the base member 21 is fixed to the lens barrel 16 by inserting male screw portions of bolts into the respective mounting holes 36 and inserting and tightening the bolts into the screw holes of the lens barrel 16. ing.

  The shaft receiving member 22 is fixed to the lower surface of the base member 21 with screws or the like. The shaft receiving member 22 supports three pairs of guide shafts 23 with the shaft support member 24. The shaft receiving member 22 is partially formed in an L-shape, and this L-shaped portion is fixed to the lower surface of the base member 21. The three pairs of guide shafts 23 are arranged in parallel directions. Each guide shaft 23 is provided in a line in the longitudinal direction of the shaft receiving member 22 and the shaft support member 24. One end portion of each guide shaft 23 is fixed to the shaft receiving member 22, and the other end portion is fixed to the shaft support member 24.

  Here, the three pairs of guide shafts 23 are distinguished from the first guide shaft pair, the second guide shaft pair, and the third guide shaft pair. In such a case, the first guide shaft pair is constituted by two guide shafts 23 arranged on the outermost side, and the second guide shaft pair is constituted by two guide shafts 23 arranged on the inner side (intermediate) thereof. It is constituted by. The third guide shaft pair is constituted by a set of two guide shafts 23 arranged on the innermost side.

  A slide member 27 is attached to each of the two guide shafts 23 constituting the first guide shaft pair. The slide member 27 is provided so as to be movable (slidable) along the guide shaft 23. Slide members 28 are attached to the two guide shafts 23 constituting the second guide shaft pair. The slide member 28 is provided so as to be movable (slidable) along the guide shaft 23. A slide member 29 is attached to each of the two guide shafts 23 constituting the third guide shaft pair. The slide member 29 is provided so as to be movable (slidable) along the guide shaft 23. Each slide member 27, 28, 29 is provided so as to freely reciprocate between the shaft receiving member 22 and the shaft support member 24 while being guided by the corresponding guide shaft pair.

  The arm member 25 is attached so as to span between the pair of slide members 27. Both end portions of the arm member 25 are fixed to the corresponding slide members 27 by screws or the like. The arm member 26 is attached so as to span between a pair of slide members 28. Both end portions of the arm member 26 are fixed to the corresponding slide members 28 by screws or the like.

  The filter holder 30 is supported by the arm member 25. A circular opening 37 is formed in the filter holder 30. The polarizing filter 33 is attached to the lower surface side of the filter holder 30 so as to close the opening 37. The polarization filter 33 is rotatably attached so that the polarization state can be changed. The filter holder 31 is supported by the arm member 26. The filter holder 31 is formed with a square (square, rectangular, etc.) opening 38. The blue enhancement filter 34 is attached to the filter holder 31 so as to close the opening 38. The filter holder 32 is supported by the slide member 29 directly or via a connecting member (not shown). The filter holder 32 is formed with a quadrangular (square, rectangular, etc.) opening 39. The blue light cut filter 35 is attached to the filter holder 32 so as to close the opening 39.

  Thus, the filter unit 15 includes three different optical filters (33, 34, 35). Specifically, one polarizing filter 33 and two color filters are provided. Of the two color filters, one color filter is configured by the blue enhancement filter 34, and the other color filter is configured by the blue light cut filter 35. The three optical filters (33, 34, 35) are supported by separate filter holders 30, 31, 32, respectively, and the respective filter holders 30, 32, 33 are attached to separate slide members 27, 28, 29. It is connected.

<3. Operation of filter unit>
Subsequently, the operation of the filter unit 15 will be described.
The filter holder 30 moves integrally with the arm member 25 connected to the slide member 27 when the pair of slide members 27 move along the two guide shafts 23 constituting the first guide shaft pair. The filter holder 31 moves integrally with the arm member 26 connected to the slide member 28 when the pair of slide members 28 move along the two guide shafts 23 constituting the second guide shaft pair. The filter holder 32 moves integrally with the slide member 29 by moving the pair of slide members 29 along the two guide shafts 23 constituting the third guide shaft pair.
FIG. 3 shows a state in which the three filter holders 30, 31, 32 are arranged so as to overlap each other, and FIG. 4 shows a state in which the three filter holders 30, 31, 32 are arranged so as to be shifted from each other. Yes.

  The polarizing filter 33 is a filter that transmits light of a specific polarization component and blocks other light. The polarizing filter 33 has, for example, two filters that overlap each other, and the effect of the polarizing filter can be adjusted by rotating one of them. The polarizing filter 33 can move forward and backward with respect to the space below the objective lens 14 by moving the filter holder 30 in a direction parallel to the axial direction of the guide shaft 23. Specifically, when the polarizing filter 33 is advanced into the space below the objective lens 14 by the movement of the filter holder 30, the polarizing filter 33 is arranged coaxially with the central axis of the objective lens 14. Further, when the polarizing filter 33 is retracted from the space below the objective lens 14 by moving the filter holder 30, the polarizing filter 33 is retracted to the space below the base member 21.

  The blue enhancement filter 34 is a type of color enhancement filter and is a filter that particularly emphasizes blue. The blue enhancement filter 34 can move forward and backward with respect to the space below the objective lens 14 by moving the filter holder 31 in a direction parallel to the axial direction of the guide shaft 23. Specifically, when the blue enhancement filter 34 is advanced into the space below the objective lens 14 by moving the filter holder 31, the blue enhancement filter 34 is arranged coaxially with the central axis of the objective lens 14. Further, when the blue enhancement filter 34 is retracted from the space below the objective lens 14 by the movement of the filter holder 31, the blue enhancement filter 34 is retracted to the space below the base member 21.

  The blue light cut filter 35 is a filter that mainly blocks light in the blue wavelength range or lower. The blue light cut filter 35 can be constituted by, for example, a sharp cut filter having a transmission limit wavelength of 440 to 520 nm. The blue light cut filter 35 can move forward and backward with respect to the space below the objective lens 14 by moving the filter holder 32 in a direction parallel to the axial direction of the guide shaft 23. Specifically, when the blue light cut filter 35 is advanced into the space below the objective lens 14 by the movement of the filter holder 32, the blue light cut filter 35 is disposed coaxially with the central axis of the objective lens 14. It becomes. When the blue light cut filter 35 is retracted from the space below the objective lens 14 by the movement of the filter holder 32, the blue light cut filter 35 is retracted to the space below the base member 21.

  From the above, the following arrangement form can be alternatively adopted for the three optical filters (33, 34, 35). In the first arrangement form, all the optical filters (33, 34, 35) are retracted from the space below the objective lens 14 and arranged. The second arrangement form is a form in which only the polarizing filter 33 is advanced into the space below the objective lens 14. The third arrangement form is a state in which only the blue enhancement filter 34 is advanced and arranged in the space below the objective lens 14. The fourth arrangement form is a form in which only the blue light cut filter 35 is advanced into the space below the objective lens 14.

  The fifth arrangement form is a form in which the polarizing filter 33 and the blue enhancement filter 34 are arranged in a space below the objective lens 14. The sixth arrangement form is a form in which the polarizing filter 33 and the blue light cut filter 35 are arranged in a space below the objective lens 14. The seventh arrangement form is a form in which a blue enhancement filter 34 and a blue light cut filter 35 are arranged in a space below the objective lens 14. In the eighth arrangement form, all the optical filters (33, 34, 35) are arranged in a space below the objective lens 14 in an overlapping manner.

  Which of the eight arrangement forms described above is used is determined by the operator's manual operation. In other words, the surgeon who uses the intraocular observation microscope 1 can set the desired arrangement form by his own manual operation.

  Incidentally, the central axis of the objective lens 14 is coaxial with the optical axis of the observation optical system 3. For this reason, when the blue enhancement filter 34 is advanced into the space below the objective lens 14, the blue enhancement filter 34 is disposed coaxially with the position of the optical axis of the observation optical system 3. Therefore, the blue emphasis filter 34 is supported so as to be movable forward and backward between a position advanced on the optical axis and a position retracted (withdrawn) from the position of the optical axis of the observation optical system 3. . Further, the support means (first support means) for supporting the blue emphasis filter 34 so as to be able to advance and retreat in this way is configured using the guide shaft 23, the slide member 29, the filter holder 32, and the like described above.

  Similarly, when the blue light cut filter 35 is advanced below the objective lens 14, the blue light cut filter 35 is arranged coaxially with respect to the position of the optical axis of the observation optical system 3. Therefore, the blue light cut filter 35 is supported so as to be movable forward and backward between the position of the observation optical system 3 along the optical axis and the position retracted from the optical axis. Yes. Further, the support means (second support means) for supporting the blue light cut filter 35 so as to be movable back and forth in this way is configured by using the above-described guide shaft 23, arm member 26, filter holder 31, and the like.

  Further, when the polarizing filter 33 is advanced into the space below the objective lens 14, the polarizing filter 33 is arranged coaxially with respect to the position of the optical axis of the observation optical system 3. Accordingly, the polarizing filter 33 is supported so as to be movable back and forth between a position that has advanced on the optical axis of the observation optical system 3 and a position that has retracted (retracted) from the position. Further, the support means (third support means) for supporting the polarizing filter 33 so as to be movable back and forth in this way is configured using the above-described guide shaft 23, arm member 25, slide member 27, filter holder 30, and the like. Yes.

<4. How to use the microscope for intraocular observation>
Next, a method for using the intraocular observation microscope according to the embodiment of the present invention will be described.
Here, as an example, as shown in FIG. 2 above, a surgical contact lens 42 is placed on the cornea of the eyeball 41, the distal end side of the end illuminator 43 is inserted into the eyeball 41, and the vitreous body is observed while observing the inside of the eye. Assume that surgery is performed.

  The end illuminator 43 is a surgical instrument that performs intraocular illumination. The end illuminator 43 is configured by using an optical fiber or the like, and irradiates light generated by a light source unit (not shown) from the tip portion. The light source unit has a plurality of different types of light sources. Here, as an example, it is assumed that the light source unit includes a halogen light source and a xenon light source. Further, the end illuminator 43 emits either one of light generated by a halogen light source or light generated by a xenon light source according to the type of light source provided in the light source unit. In addition, the wavelength of light generated by the xenon light source can be set to either 420 nm or 515 nm. Then, for example, switching means (buttons provided on the operation unit of the light source unit) determines whether the light emitted from the end illuminator 43 is light from a halogen light source, 420 nm light from a xenon light source, or 515 nm light from a xenon light source , Switches, levers, etc.) can be arbitrarily selected by the surgeon or his assistant.

  First, in the vitreous surgery, the inner boundary membrane staining method using the aforementioned staining solution such as ICG, TB, BBG or the like is employed. However, ICG and TB have recently reported a number of reports of tissue damage to the retina. For example, triamcinone acetonide (hereinafter referred to as “TA”) is also known as an alternative staining solution. However, TA is effective for visualizing the vitreous body, but has a drawback that the visibility of the inner boundary film is inferior. In response to these problems, BBG is considered to exhibit good staining on the inner limiting membrane and to have high tissue safety to the retina. Certainly, a cold-colored staining solution such as BBG has a substantially diagonal hue as compared with the color tone of the retinal pigment epithelial cells, and is expected to obtain clear contrast and visibility. However, the boundary between the stained region stained with BBG and the other region may be unclear depending on the patient. Therefore, in the embodiment of the present invention, assuming a case where BBG is used as a staining solution, a technique suitable for performing a safer and more reliable operation by further emphasizing the hue of the stained region of BBG. To do. However, the present invention may be applied to the case of observing a stained region with a staining solution other than BBG (preferably, a blue staining solution).

(First use example)
When irradiating light from a halogen light source from the tip of the end illuminator 43, as shown in FIG. That is, the fifth arrangement form is adopted among the eight arrangement forms described above. As a result, the light irradiated into the eyeball 41 from the distal end portion of the end illuminator 43 is reflected by the fundus of the eyeball 41 as shown by the broken line in the figure, and then emitted to the lens barrel 16 side through the contact lens 42. Further, the light thus emitted passes through the polarization filter 33 and the blue enhancement filter 34 in order, and then is taken into the eyepiece lens 11 and finally reaches the eyepiece.

  In this way, when light from a halogen light source is used as irradiation light, when the surgeon observes the inside of the eye through the polarizing filter 33 and the blue enhancement filter 34, the whole is compared with the case of observing without passing through these optical filters. Although it became darker, it was found that the boundary between the stained region of BBG and the other region became clear and the hue was emphasized. In addition, when a polarizing filter or a blue enhancement filter was used alone, no remarkable hue enhancement effect was observed. Moreover, the inventors measured the spectral irradiance distribution of the reflected light from the fundus for confirmation. The measurement result will be described later.

(Second usage example)
When irradiating 420 nm light from the xenon light source from the tip of the end illuminator 43, as shown in FIG. 5, the polarizing filter 33 and the blue light cut filter 35 are arranged in a space below the objective lens 14. That is, the sixth arrangement form is adopted among the eight arrangement forms described above. As a result, the light irradiated into the eyeball 41 from the tip of the end illuminator 43 is reflected from the fundus of the eyeball 41 and then emitted to the lens barrel 16 through the contact lens 42 as shown by the broken line in the figure. Is done. Further, the light thus emitted passes through the polarization filter 33 and the blue light cut filter 35 in order, and then is taken into the eyepiece lens 11 and finally reaches the eyepiece.

  In this way, when 420 nm light from a xenon light source is used as irradiation light, when the surgeon observes the inside of the eye through the polarizing filter 33 and the blue light cut filter 35, compared to the case of observing without passing through these optical filters. Although it became dark overall, it was found that the boundary between the stained region of BBG and the other region became clear and the hue was emphasized. Further, in the observation using 515 nm light from the xenon light source as the irradiation light, the effect of improving the visibility of the stained region of BBG was recognized. While the 515 nm light from the xenon light source is yellow light, the blue dyeing liquid containing BBG has a characteristic of absorbing this yellow light. For this reason, when 515 nm light from a xenon light source is irradiated on the fundus and the reflected light is incident on the polarizing filter 33 and the blue light cut filter 35, the reflected light from the stained region of BBG is blocked by the filter. Reflected light from other parts passes through the filter. For this reason, it seems that the hue of a dyeing | staining area | region and the other part is emphasized. As in the case of the halogen light source, the inventors measured the spectral radiant intensity distribution of the reflected light from the fundus. The measurement result will be described later.

  In addition, in either case of adopting the first usage method or the second usage method, as a secondary effect, there is a dawn caused by light reflected on the surface of a surgical instrument such as a vitreous cutter or an insulator. Reduced. Surface reflections of surgical instruments in the eye can interfere with surgery. For this reason, there is also provided a surgical instrument having a surface roughened for the purpose of suppressing surface reflection of a surgical instrument such as a vitreous cutter. However, when this type of surgical instrument is used, the eye tissue may be damaged by contact with minute irregularities formed on the surface of the surgical instrument. On the other hand, according to the above secondary effect, even if the surface of the surgical instrument is smooth, the dawn due to reflected light from the surface is reduced. For this reason, it is possible to ensure a good visual field without taking the risk of damaging the eye tissue. Further, when an intraocular lens is inserted into the eyeball 41, an effect of reducing brightening due to surface reflection of the intraocular lens can be obtained.

<5. Measurement results>
Hereinafter, the measurement results performed by the inventors will be described.
In this experiment, vitrectomy was performed on the eyeball 41 of the removed pig eye to replace the liquid, and the illumination light (hereinafter referred to as “intraocular illumination light”) was applied to the fundus before and after the inner boundary membrane was stained with BBG. The spectral irradiance distribution when irradiated was examined.
The equipment used in the experiment is as follows.
Spectroradiometer (USH-40V, USHIO INC.)
Microscope (OPM1 VISU 1FR manufactured by Zeiss)
Halogen light source (Oertli OS3)
Xenon light source (DORC Bright Star)
The optical filters used in the experiment are as follows.
Polarizing filter (Circular PL (W) Vernier manufactured by Kenko Corporation)
Blue emphasis filter (Blue Hansar Light manufactured by Marumi Koki Co., Ltd.)
Blue light cut filter (Sharp cut filter Y (SCF-50S-52Y) manufactured by Sigma Kogyo Co., Ltd.)

  FIG. 6 is a diagram showing a spectral irradiance distribution graph obtained when the fundus of the pig eye is irradiated by applying intraocular illumination light from a halogen light source. In this graph, the case where the optical filter of the filter unit 15 is not used is indicated by a double line, the case where the polarizing filter 33 and the blue enhancement filter 34 are used is indicated by a solid line, and the absorbance of BBG is indicated by a broken line.

  FIG. 7 is a diagram showing a spectral irradiance distribution graph obtained when the fundus of a pig eye is irradiated by applying 420 nm intraocular illumination light from a xenon light source. In this graph, the case where the optical filter of the filter unit 15 is not used is indicated by a double line, and the case where the polarizing filter 33 and the blue light cut filter 35 are used is indicated by a solid line. Further, the case without BBG staining is indicated by a dotted line, and the absorbance of BBG is indicated by a broken line.

  FIG. 8 is a diagram showing a spectral irradiance distribution graph obtained when irradiating the fundus of a pig eye by applying 515 nm intraocular illumination light from a xenon light source. In this graph, the case where the optical filter of the filter unit 15 is not used is indicated by a double line, the case where the polarizing filter 33 and the blue light cut filter 35 are used is indicated by a solid line, and the absorbance of BBG is indicated by a broken line. .

Hereinafter, the measurement result will be considered.
About FIG. 6 In the spectral irradiance distribution when no filter is used, an illuminance peak was observed on the shorter wavelength side than the BBG absorbance peak. When the polarizing filter 33 and the blue enhancement filter 34 were used, the illuminance at a wavelength shorter than the BBG absorbance peak was reduced, and the illuminance distribution became flat. As a result, the illuminance of the BBG stained area is lowered, and the illuminance of other portions is considered to be relatively improved. Due to this effect, the BBG stained area became dark and the other parts became bright, so the boundary portion became clear and the hue was emphasized.

About FIG. 7 In the spectral irradiance distribution when no filter is used, an illuminance peak was observed on the shorter wavelength side than the BBG absorbance peak. When the polarizing filter 33 and the blue light cut filter 35 were used, the illuminance at a wavelength shorter than the BBG absorbance peak was greatly reduced, and the illuminance distribution was relatively flat. As a result, the illuminance of the BBG stained area is lowered, and the illuminance of other parts is relatively improved. Due to this effect, the BBG stained area is darkened and the other parts are brightened. It became clear that the hue was emphasized.

About FIG. 8 When the spectral irradiance distribution when no filter was used was measured, an illuminance peak was observed on the shorter wavelength side than the BBG absorbance peak. When the polarizing filter 33 and the blue light cut filter 35 were used, the illuminance at a wavelength shorter than the BBG absorbance peak was greatly reduced, and the illuminance distribution was relatively flat. As a result, the illuminance of the BBG stained area is lowered, and the illuminance of the other parts is relatively improved, so that the BBG stained area becomes darker and the other parts become brighter, so that the boundary becomes clear. It is thought that the hue was emphasized.

<6. Modified example>
The technical scope of the present invention is not limited to the above-described embodiments, and includes various modifications and improvements as long as the specific effects obtained by the constituent elements of the invention and combinations thereof can be derived.

  For example, in the above-described embodiment, the filter unit 15 is configured to manually switch the combination of optical filters used for intraocular observation. However, the present invention is not limited to this, and a drive source such as a motor and its drive state are not limited thereto. It is also possible to automatically perform the switching by providing a control means for controlling the above. Further, when the type of the light source to be used is switched, it is possible to receive the switching signal and automatically switch the combination of optical filters used for intraocular observation. Specifically, when the surgeon operates the operation unit such as the light source unit to switch the type and wavelength of the light source to be used, the control means receives the switching signal and the control means determines the type of light source or the emission wavelength. It is possible to adopt a configuration in which the drive source is driven and controlled so as to obtain a combination of optical filters determined in advance.

  Further, the vertical positional relationship between the blue enhancement filter 34 and the blue light cut filter 35 in the filter unit 15 may be reversed. Further, the optical filter included in the intraocular observation microscope 1 or the filter unit 15 is not only configured to include the polarization filter 33, the blue enhancement filter 34, and the blue light cut filter 35, but also the polarization filter 33 and the blue enhancement filter. The structure provided only with 34, or the structure provided only with the polarizing filter 33 and the blue light cut filter 35 may be sufficient. In either case, it is preferable that a plurality of optical filters be selectively used depending on the observation target.

  DESCRIPTION OF SYMBOLS 1 ... Microscope for intraocular observation, 2 ... Illumination optical system, 3 ... Observation optical system, 15 ... Filter unit, 33 ... Polarizing filter, 34 ... Blue emphasis filter, 35 ... Blue light cut filter

Claims (5)

With an observation optical system for observing the inside of the eye irradiated with illumination light while making the eyeball an object to be observed,
The observation optical system includes a blue enhancement filter and a polarization filter disposed on the object side of the blue enhancement filter, and the inside of the eye can be observed through the blue enhancement filter and the polarization filter. A microscope for intraocular observation. With an observation optical system for observing the inside of the eye irradiated with illumination light while making the eyeball an object to be observed,
The observation optical system includes a blue light cut filter and a polarization filter disposed closer to the object side than the blue light cut filter, and can observe the inside of the eye through the blue light cut filter and the polarization filter. A microscope for intraocular observation characterized by the above. With an observation optical system for observing the inside of the eye irradiated with illumination light while making the eyeball an object to be observed,
The observation optical system has a plurality of optical filters including at least one of a blue enhancement filter and a blue light cut filter and a polarizing filter, and the inside of the eye can be observed selectively using the plurality of optical filters. A microscope for intraocular observation, comprising: a filter unit. A filter unit that is used by being mounted on an intraocular observation microscope equipped with an observation optical system for observing the inside of an eye irradiated with illumination light while using an eyeball as an object to be observed.
It has a plurality of optical filters including at least one of a blue enhancement filter and a blue light cut filter and a polarizing filter, and the inside of the eye can be observed by selectively using the plurality of optical filters. Filter unit to be used. The plurality of optical filters include the blue enhancement filter, the blue light cut filter, and the polarization filter,
First support means for supporting the blue enhancement filter so as to be movable back and forth with respect to the position of the optical axis of the observation optical system;
Second support means for supporting the blue light cut filter so as to be movable back and forth with respect to the position of the optical axis of the observation optical system;
The filter unit according to claim 4, further comprising third support means for supporting the polarizing filter so as to be movable back and forth with respect to the position of the optical axis of the observation optical system.

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