JP2012055441A - Medicine injection device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medicine injection device for filling a container with a medicine while preventing generation of core ring or deformation of the bevel of a needle.SOLUTION: A pre-filled syringe 1 includes an outer cylinder 2, a cannula 3, a needle hub 4 and a sealing member 6. The outer cylinder 2 stores the medicine M and has a discharge portion 12 for discharging the medicine M. The needle hub 4 has an insertion portion 18 for allowing the discharge portion 12 to be inserted thereinto. The needle hub 4 can move in the axial direction of the discharge portion 12. The sealing member 6 is arranged in a space S formed by the tip end surface 12b of the discharge portion 12 and the insertion portion 18 of the needle hub 4. By moving the needle hub 4 in the axial direction, the sealing member 6 is brought into liquid-tight contact with the tip end surface 12b of the discharge portion 12 (first state), or it is separated from the tip end surface 12b of the discharge portion 12 to connect the cannula 3 with the discharge portion 12 and to form a flow path for passing the medicine M (second state).

Description

  The present invention relates to a drug injection device that has a needle tube and stores a drug in a container in advance.

  In recent years, a medicine injection device in which a medicine is filled in advance in a syringe which is a storage container, a so-called prefilled syringe has been widely used (for example, see Patent Document 1). In the prefilled syringe described in Patent Document 1, a double-ended needle held by a needle hub is attached to an outer cylinder prefilled with a medicine.

  The needle tip on the side inserted into the outer cylinder of the double-ended needle is covered with a rubber cap. Then, the needle tip of the double-ended needle penetrates through the rubber cap, so that the inside of the outer cylinder and the outside of the outer cylinder are communicated by the double-ended needle. In such a medicine container, it is not necessary to suck the medicine from the vial into the syringe when the medicine is administered, and the time required for the administration can be shortened and the waste of the medicine can be reduced.

A prefilled syringe having a needle tube is also used. Next, a prefilled syringe having a conventional needle tube will be described with reference to FIG.
FIG. 15 is a cross-sectional view showing a conventional prefilled syringe.

  As shown in FIG. 15, the prefilled syringe 100 includes an outer cylinder 102 that is a storage container for storing the medicine M, a needle tube 103, a cap 104, and a pusher (not shown). The outer cylinder 102 is formed in a substantially cylindrical shape with both ends opened. A needle tube 103 is fixed to one end of the outer cylinder 102 in the axial direction. A pusher (not shown) is inserted into the other end portion of the outer cylinder 102 in the axial direction.

  A cap 104 is detachably attached so as to cover the needle tip of the needle tube 103 and one end of the outer cylinder 102. The cap 104 is formed in a hollow substantially truncated cone shape. Inside the cap 104 is provided a rubber material 105 into which the needle tip of the needle tube 103 is punctured. And by puncturing the needle tip of the needle tube 103 in the rubber material 105 provided in the cap 104, the medicine M filled in the outer cylinder 102 is prevented from leaking from the needle tip of the needle tube 103 in a state before use. Yes.

JP-A-8-117334

  However, in the prefilled syringe described in Patent Document 1, a rubber cap that covers one side of the double-ended needle is attached to the tip of the double-ended needle so that one side of the double-ended needle is inserted into the syringe and the syringe and the double-ended needle communicate with each other. Needed to puncture. For this reason, there is a possibility that so-called coring, in which the rubber cap is scraped off by the tip of the double-ended needle, may occur.

  Further, in the prefilled syringe 100 shown in FIG. 15, the medicine in the outer cylinder 102 is sealed by puncturing the needle member of the needle tube 103 into the rubber material 105 provided on the cap 104. As a result, when the needle tip of the needle tube 103 is punctured into the rubber material 105, there is a problem that coring occurs or the needle tip is deformed and hurt by the rubber material 105.

  An object of the present invention is to allow the medicine to be sealed in the storage container without causing the coring or the needle tip of the needle tube to be deformed in consideration of the above-mentioned problems, and to communicate the storage container and the needle tube. An object of the present invention is to provide a medicine injection device that can be made to operate.

  In order to solve the above problems and achieve the object of the present invention, a drug injection device of the present invention has a storage container having a discharge part for storing a drug and discharging the drug, and a needle tip that can puncture a living body. A needle tube. Also, a needle hub having a holding portion for holding the needle tube and an insertion portion into which the discharge portion is inserted, which is movable in the axial direction of the discharge portion of the storage container, and a distal end surface of the discharge portion and insertion of the needle hub And a sealing member disposed in a space formed by the portion. The seal member moves the needle hub in the axial direction so that the needle tube and the discharge portion communicate with each other in a first state where the tip end surface of the discharge portion comes into liquid-tight contact with the tip portion of the discharge portion. And it changes to the 2nd state in which the channel through which a medicine passes is formed.

  In addition, another drug injection device of the present invention includes a storage container having a discharge portion for storing a drug and discharging the drug, and a needle tube having a needle tip that can puncture a living body. In addition, it has a holding part for holding the needle tube, and an insertion part in which the discharge part is inserted and an opposing surface facing the tip surface of the discharge part is formed, and is movable in the axial direction of the discharge part of the storage container. Needle hub. And a seal member disposed in a space formed by the distal end surface of the discharge portion and the insertion portion of the needle hub, and having a through hole connecting the distal end surface side of the discharge portion and the opposite surface side of the needle hub; It is equipped with. Then, the seal member moves the needle hub in the axial direction so as to be in liquid-tight contact with the distal end surface of the discharge portion, and the closed state of the through hole is released. At the same time, the needle tube and the discharge portion communicate with each other through the through-hole, and the state changes to a second state in which a flow path through which the drug passes is formed.

  According to the pharmaceutical injection device of the present invention, when the needle tube and the storage container are communicated with each other, it is not necessary to puncture the needle tip of the needle tube into a sealing member such as a rubber cap. It is possible to prevent deformation and pain.

It is sectional drawing which shows 1st Embodiment of the prefilled syringe applied as a chemical injection device of this invention. It is sectional drawing which shows the state which inject | pours the chemical | medical agent concerning the 1st Embodiment of the prefilled syringe applied as a chemical | medical agent injection apparatus of this invention of this invention. FIG. 2 (A) is a top view and FIG. 2 (B) is a side view showing an inflow passage securing means according to a first embodiment of a prefilled syringe applied as a medicine injection device of the present invention. is there. It is sectional drawing which shows the 2nd Embodiment of the prefilled syringe applied as a chemical injection device of this invention. FIG. 5 is a cross-sectional view taken along line EE ′ shown in FIG. 4. FIG. 5 is a cross-sectional view taken along line FF ′ shown in FIG. 4. It is sectional drawing which shows the 3rd Embodiment of the prefilled syringe applied as a chemical injection device of this invention. It is sectional drawing which shows the state which inject | pours the chemical | medical agent concerning the 3rd Embodiment of the prefilled syringe applied as a chemical injection apparatus of this invention of this invention. It is sectional drawing which expands and shows the principal part of the prefilled syringe shown in FIG. It is sectional drawing which expands and shows the principal part concerning the 4th Embodiment of the prefilled syringe applied as a chemical injection device of this invention. It is sectional drawing which shows the 5th Embodiment of the prefilled syringe applied as a chemical injection device of this invention. It is sectional drawing which shows the state which inject | pours the chemical | medical agent concerning the 5th Example of the prefilled syringe applied as a chemical | medical agent injection apparatus of this invention of this invention. It is sectional drawing which shows the 6th Embodiment of the prefilled syringe applied as a chemical injection device of this invention. It is sectional drawing which shows the state which inject | pours the chemical | medical agent concerning the 6th Embodiment of the prefilled syringe applied as a chemical | medical agent injection apparatus of this invention of this invention. It is sectional drawing which shows the conventional prefilled syringe with a needle | hook.

Embodiments of the pharmaceutical injection device of the present invention will be described below with reference to FIGS. In addition, the same code | symbol is attached | subjected to the common member in each figure. The present invention is not limited to the following form.
The description will be given in the following order.
1. First embodiment example 1-1. Configuration example of drug injection device 1-2. 1. Method of using drug injection device Second embodiment example 3. FIG. 3. Third embodiment example 4. Fourth embodiment example 5. Fifth embodiment Sixth embodiment

<1. First Embodiment>
1-1. Configuration Example of Drug Injection Device First, a first embodiment example (hereinafter referred to as “this example”) of a prefilled syringe applied as a drug injection device of the present invention will be described with reference to FIGS.
FIG. 1 is a cross-sectional view showing a first state of the seal member in the prefilled syringe of this example, and FIG. 2 is a cross-sectional view showing a second state of the seal member in the prefilled syringe. FIG. 3A and FIG. 3B are a top view and a side view showing the inflow channel securing means.

  The prefilled syringe 1 of this example stores a medicine M to be administered to a living body in advance. As shown in FIG. 1, the prefilled syringe 1 includes an outer cylinder 2 that stores the medicine M, a hollow needle tube 3 having a needle hole 3b, a needle hub 4 that holds the needle tube 3, a pusher (not shown), A seal member 6 and an inflow channel securing means 7 are provided.

  In this example, the drug M stored in advance in the prefilled syringe 1 may be any drug that is normally used as an injection. For example, protein medical products such as antibodies, peptide medical products such as hormones, Nucleic acid medical products, cell medicines, blood products, vaccines to prevent various infectious diseases, anticancer drugs, narcotic drugs, narcotics, antibiotics, steroids, proteolytic enzyme inhibitors, sugar injection solutions such as heparin, glucose, Examples include electrolyte correction injection solutions such as sodium chloride and potassium lactate, vitamins, fat emulsions, contrast agents, and stimulants.

[Outer cylinder]
First, the outer cylinder 2 will be described.
The outer cylinder 2 showing a specific example of the storage container is formed in a cylindrical shape, and both ends in the axial direction are open. The outer cylinder 2 includes a substantially cylindrical storage portion 11 that stores the medicine M and a substantially cylindrical discharge portion 12 to which the needle hub 4 is attached. A pusher (not shown) is inserted into the storage portion 11 from the other end side in the axial direction.

  The discharge part 12 is provided continuously from one end of the storage part 11 in the axial direction. The diameter of the discharge part 12 is set smaller than the diameter of the storage part 11. A discharge port 12 a for discharging the medicine M is formed in the discharge unit 12.

  Further, a screw portion 13 and an O-ring 14 are provided on the outer peripheral surface of the discharge portion 12. The O-ring 14 is disposed at the end of the discharge unit 12 opposite to the storage unit 11. The O-ring 14 is provided continuously along the circumferential direction on the outer peripheral surface of the distal end portion of the discharge portion 12. Further, the screw portion 13 is formed in a bulging portion 16 that bulges outward from the outer peripheral surface of the discharge portion 12 in the radial direction.

  The material of the outer cylinder 2 is, for example, polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer. And various resins such as polyesters such as polyethylene terephthalate, butadiene-styrene copolymers, and polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12). Among them, it is preferable to use a resin such as polypropylene, cyclic polyolefin, polyester, or poly- (4-methylpentene-1) because it is easy to mold. In addition, it is preferable that the material of the outer cylinder 2 is substantially transparent in order to ensure internal visibility.

  In addition, although the example which formed the shape of the outer cylinder 2 in the substantially cylindrical shape was demonstrated in this example, the shape of the outer cylinder 2 may be a hollow square column shape or a hexagonal column shape. Furthermore, although the example using the substantially cylindrical outer cylinder 2 as a storage container was demonstrated, it is not limited to this. As a storage container, the storage part which stores a chemical | medical agent using the sheet | seat which has flexibility, for example may be formed in the bag shape. In addition, when forming a storage part in a bag shape, a pusher can be omitted.

[Needle tube]
Next, the needle tube 3 will be described.
The needle tube 3 has a size of 10 gauge (outside diameter of about 3.4 mm) to 36 gauge (outside diameter of about 0.1 mm), preferably 14 gauge to 33 gauge (outer diameter: about 1.6 to 0). 0.2 mm), more preferably 28 gauge to 33 gauge (outer diameter: about 0.36 to 0.2 mm). At one end of the needle tube 3, a blade surface 3a for making the needle tip an acute angle is formed.

  Examples of the material of the needle tube 3 include stainless steel, but are not limited thereto, and aluminum, aluminum alloy, titanium, titanium alloy, and other metals can be used. As the needle tube 3, not only a straight needle but also a double-ended needle or a tapered needle at least partially tapered can be used. As the tapered needle, the proximal end portion has a thicker outer diameter than the needle distal end portion, and the intermediate portion may have a tapered structure. Further, the cross-sectional shape of the needle tube 3 may be not only a circle but also a polygon such as a triangle.

[Needle hub]
Next, the needle hub 4 will be described.
The needle hub 4 has a shape in which two cylinders having different diameters are connected along the axial direction. The needle hub 4 includes a holding portion 17 that holds the needle tube 3 and an insertion portion 18 into which the discharge portion 12 of the outer cylinder 2 is inserted. One side of the needle hub 4 in the axial direction is a holding portion 17, and the other side in the axial direction is an insertion portion 18.

  The diameter of the holding part 17 is set smaller than the diameter of the insertion part 18. The needle tube 3 is fixed to the holding portion 17 by a fixing method such as high-frequency welding, bonding with an adhesive, or insert molding. The needle tip of the needle tube 3 protrudes from one side of the holding portion 17 in the axial direction.

  The insertion portion 18 is provided continuously at the other end in the axial direction of the holding portion 17. The insertion part 18 is formed with an insertion hole 18a into which the discharge part 12 of the outer cylinder 2 is inserted. The inner diameter of the insertion hole 18 a is set to a size corresponding to the outer diameter of the discharge part 12. Further, a screw groove 19 that is screwed with the screw portion 13 of the discharge portion 12 is formed on the inner wall of the insertion hole 18 a of the insertion portion 18.

  Further, when the discharge part 12 of the outer cylinder 2 is inserted into the insertion hole 18 a of the insertion part 18, the O-ring 14 provided in the discharge part 12 comes into liquid-tight contact with the inner wall of the insertion hole 18 a of the insertion part 18. Thereby, when the medicine M is discharged, it is possible to prevent the medicine M from leaking from the gap between the discharge portion 12 and the insertion portion 18.

  An inner flange portion 21 is formed at the end of the insertion portion 18 opposite to the holding portion 17. The inner flange portion 21 is a flange that protrudes substantially vertically from the inner wall of the insertion hole 18a toward the radially inward direction. The inner flange portion 21 may be provided continuously along the circumferential direction of the inner wall of the insertion hole 18a, or a plurality of inner flange portions 21 may be provided at intervals in the circumferential direction. Furthermore, you may make it the inner flange part 21 protrude from one place of the inner wall of the insertion hole 18a.

  The bulging portion 16 provided on the inner flange portion 21 and the discharge portion 12 abuts to restrict the movement of the needle hub 4 and prevent the needle hub 4 from falling off the outer cylinder 2. The inner flange portion 21 and the bulging portion 16 constitute one specific example of the regulating means of the present invention.

  Furthermore, an inflow port 22 through which the medicine M passes is formed on the opposing surface 18b of the insertion portion 18 that faces the distal end surface 12b of the discharge portion 12. The inflow port 22 communicates with the needle hole 3 b of the needle tube 3 held by the holding unit 17.

  Examples of the material of the needle hub 4 include synthetic resins such as polycarbonate, polypropylene, and polyethylene.

  The shape of the needle hub 4 is not limited to a cylindrical shape, and may be formed in a rectangular tube shape such as a rectangular column or a hexagonal column having a cylindrical hole at the center. Furthermore, in this example, although the example which comprised the control means by the inner flange part 21 and the bulging part 16 was demonstrated, it is not limited to this. For example, a protrusion may be provided at a predetermined position of the screw groove 19.

  Moreover, although the example which connected by screwing the needle hub 4 and the outer cylinder 2 was demonstrated, the connection method of the needle hub 4 and the outer cylinder 2 is not limited to this. For example, a locking portion is provided in the insertion hole 18 a of the insertion portion 18, and a locking receiving portion that locks the locking portion on the outer peripheral surface of the discharge portion 12 is provided. Then, the needle hub 4 and the outer cylinder 2 may be connected by locking the locking portion and the locking receiving portion.

[Seal member]
Next, the seal member 6 will be described.
The seal member 6 is formed in a substantially cylindrical shape. The diameter of the seal member 6 is set to be larger than the inner diameter of the discharge port 12a of the discharge portion 12, and is set to be smaller than the inner diameter of the insertion hole 18a of the insertion portion 18. Therefore, a gap is formed between the seal member 6 and the insertion hole 18 a of the insertion portion 18.

  The seal member 6 is disposed in a space S formed by the insertion portion 18 of the needle hub 4 and the distal end surface 12 b of the discharge portion 12. The seal member 6 is sandwiched between the facing surface 18 b of the needle hub 4 and the distal end surface 12 b of the discharge portion 12 in the outer cylinder 2 together with an inflow channel securing means 7 described later. The seal member 6 is in liquid-tight contact with the distal end surface 12b of the discharge portion 12, and closes the opening of the discharge port 12a. The state of the seal member 6 at this time is referred to as a first state. Thereby, it can prevent that the chemical | medical agent M leaks from the outer cylinder 2 in the state before use.

  As shown in FIG. 2, when the needle hub 4 is moved so that the distance between the facing surface 18b of the needle hub 4 and the distal end surface 12b of the discharge portion 12 is greater than the thickness of the seal member 6, the needle hub 4 and The holding of the seal member 6 and the inflow passage securing means 7 by the outer cylinder 2 is released. Therefore, the seal member 6 can move in the space S. As a result, the seal member 6 moves away from the distal end surface 12b of the discharge portion 12 from the first state, and changes to the second state in which the needle tube 3 and the discharge portion 12 are communicated.

  Furthermore, the material of the seal member 6 is not particularly limited, but it is preferable that the seal member 6 is made of an elastic material in order to improve the liquid tightness with the outer cylinder 2. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, various thermoplastic elastomers such as polyurethane, polyester, polyamide, olefin, and styrene, or Elastic materials such as a mixture thereof can be used.

  In this example, the shape of the seal member 6 is formed in a substantially cylindrical shape, but may be formed in various other shapes such as a square column and a hexagonal column.

[Inflow channel securing means]
Next, the inflow channel securing means 7 will be described.
The inflow channel securing means 7 is disposed between the seal member 6 and the facing surface 18 b of the needle hub 4. As shown in FIGS. 3A and 3B, the inflow passage securing means 7 is composed of a plate-like member 23 formed in a substantially disc shape. Eight grooves 24 are formed on one surface 23 a of the plate-like member 23. The eight grooves 24 are formed radially from the approximate center of the one surface 23a toward the radially outward direction. Further, the center of one surface 23 a of the plate-like member 23 faces the inlet 22 of the insertion portion 18. And as shown in FIG. 3, this groove | channel 24 becomes an inflow path through which the chemical | medical agent M passes.

  The material of the plate-like member 23 is not particularly limited, but a material having such a hardness that the groove 24 as the inflow path is not crushed by the water pressure when the medicine M is discharged is preferable.

  In addition, in this example, although the example which formed the plate-shaped member 23 which comprises the inflow channel securing means 7 in the substantially disk shape was demonstrated, it is not limited to this, According to the shape of the needle hub 4, You may form in flat form, such as a rectangle and a hexagon. Further, the number of grooves 24 is not limited to eight, and may be seven or less or nine or more.

  Moreover, although the example which forms the inflow path through which the chemical | medical agent M passes by the groove | channel 24 was demonstrated, it does not limit to this, For example, a processus | protrusion is provided in one surface 23a of the plate-shaped member 23, and this processus | protrusion and needle hub 4 You may make it form an inflow path by the opposing surface 18b.

1-2. Next, the usage method of the prefilled syringe 1 of this example is demonstrated with reference to FIG.1 and FIG.2.

  First, as shown in FIG. 1, in a state before use, the screw portion 13 of the discharge portion 12 and the screw groove 19 of the needle hub 4 are screwed together. At this time, the seal member 6 is sandwiched between the front end surface 12 b of the discharge portion 12 and the facing surface 18 b of the needle hub 4 together with the plate-like member 23 constituting the inflow passage securing means 7. It is in liquid-tight contact with 12b (first state).

  Thereby, it can prevent that the chemical | medical agent M accommodated in the outer cylinder 2 leaks. As a result, unlike the conventional prefilled syringe 100 shown in FIG. 15, there is no need to puncture the needle tip of the needle tube 3 into a sealing member such as a rubber material, so that coring occurs or the needle tip of the needle tube 3 It becomes possible to prevent it from being injured.

  Next, in use, the needle hub 4 is first twisted to release the screw engagement between the threaded portion 13 of the discharge portion 12 and the thread groove 19 of the needle hub 4. Then, as shown in FIG. 2, the needle hub 4 is moved in the axial direction of the discharge portion 12, and the distance between the facing surface 18 b of the needle hub 4 and the distal end surface 12 b of the discharge portion 12 is increased. Here, the inner flange portion 21 is provided in the insertion portion 18 of the needle hub 4, and the bulging portion 16 is provided in the discharge portion 12. Therefore, it is possible to prevent the needle hub 4 from falling out of the outer cylinder 2 by contacting the bulging portion 16 and the inner flange portion 21.

  When the distance between the facing surface 18b of the needle hub 4 and the distal end surface 12b of the discharge portion 12 is greater than or equal to the thickness of the seal member 6, the seal member 6 and the plate-like member 23 are clamped by the needle hub 4 and the outer cylinder 2. Canceled. As a result, the seal member 6 can move within the insertion portion 18, and the liquid tightness of the outer cylinder 2 is released by the seal member 6. That is, the seal member 6 changes from the first state to the second state.

  Even if the seal member 6 is in close contact with the distal end surface 12b of the discharge portion 12 due to long-term storage, the seal member is discharged by pressing the unillustrated pusher and discharging the medicine M stored in the storage portion 11. 6 separates from the front end surface 12b of the discharge part 12 by the water pressure of the medicine M.

  Here, the seal member 6 may be pushed by the water pressure of the medicine M to block the inlet 22 of the needle hub 4. However, in this example, a plate-like member 23 having a groove 24 serving as an inflow passage is provided between the seal member 6 and the facing surface 18b of the insertion portion 18 in which the inflow port 22 is formed. As a result, the inlet 22 can be prevented from being blocked by the seal member 6, and an inflow path through which the drug M passes can be secured by the groove 24 of the plate-like member 23.

  Further, an O-ring 14 is provided on the outer peripheral surface of the distal end portion of the discharge portion 12. Thereby, it is possible to prevent the medicine M from leaking between the discharge part 12 and the insertion part 18.

  Then, as shown in FIG. 2, the medicine M passes through the gap between the seal member 6 and the insertion hole 18 a, and further reaches the inlet 22 through the groove 24 of the plate-like member 23. As a result, the medicine M passes through the needle hole 3b of the needle tube 3 and is discharged to the outside. Therefore, the outer tube 2 and the needle tube 3 can be communicated without puncturing the needle tip of the needle tube 3 into a sealing member such as a rubber cap.

<2. Second Embodiment>
Next, a second embodiment of the prefilled syringe applied as the drug injection device of the present invention will be described with reference to FIGS.
FIG. 4 is a cross-sectional view showing a state when the prefilled syringe according to the second embodiment is used. 5 is a cross-sectional view taken along the line EE ′ shown in FIG. 4, and FIG. 6 is a cross-sectional view taken along the line FF ′ shown in FIG.

  The prefilled syringe 31 according to the second embodiment differs from the prefilled syringe 1 according to the first embodiment in that the seal member and the inflow passage securing means are fixed to the needle hub. Therefore, here, the seal member, the inflow channel securing means, and the needle hub will be described, and the same reference numerals are given to the portions common to the prefilled syringe 1 and the redundant description will be omitted.

  As shown in FIG. 4, the needle hub 32 has a holding portion 33 and an insertion portion 34. Two fixing pieces 35 are provided on the inner wall of the insertion hole 34 a of the insertion portion 34. The two fixing pieces 35 are formed at corners where the opposing surface 34b and the side walls of the insertion hole 34a are connected. Moreover, as shown in FIG. 5, the two fixed pieces 35 are disposed at positions facing each other.

  The plate-like member 38 constituting the inflow path securing means 37 is formed with a groove 39 that forms the inflow path and two fitting portions 40 into which the fixing pieces 35 are fitted. The two fitting portions 40 are concave portions that are recessed from the outer edge of the plate-shaped member 38 toward the radially inward direction. The plate-like member 38 is fixed to the needle hub 32 by fitting the fitting portion 40 and the fixing piece 35.

  Furthermore, as shown in FIG. 6A, a fixing portion 41 is formed on the other surface 38b opposite to the one surface 38a where the groove 39 is formed in the plate-like member 38. The fixing portion 41 is two columnar protrusions 42 protruding substantially perpendicularly from the other surface 38b. The two protrusions 42 are inserted into the seal member 36. Therefore, the seal member 36 and the plate-like member 38 are fixed integrally. That is, the needle hub 32, the plate-like member 38, and the seal member 36 are fixed integrally.

  Other configurations are the same as those of the prefilled syringe 1 according to the above-described first embodiment, and thus description thereof is omitted. Also with the prefilled syringe 31 having such a configuration, the same operations and effects as those of the prefilled syringe 1 according to the above-described first embodiment can be obtained.

  In the prefilled syringe 31 according to the second embodiment, when the needle hub 32 is twisted in order to release the screw engagement between the screw portion 13 of the discharge portion 12 and the screw groove of the needle hub 32, the seal member 36 and The plate-like member 38 rotates integrally with the needle hub 32. At this time, a shearing force in the rotational direction acts between the seal member 36 and the distal end surface 12 b of the discharge portion 12. As a result, even if the seal member 36 is in close contact with the distal end surface 12b of the discharge portion 12 by long-term storage, the liquid-tight state by the seal member 36 can be easily released.

  In addition, in FIG. 6A, although the example which comprised the fixing | fixed part 41 as two protrusion 42 which protruded in the substantially cylindrical shape was demonstrated, it is not limited to this. For example, the fixing portion 41B shown in FIG. 6B is a convex portion 42B protruding in a substantially cross shape. That is, the shape of the fixing portion provided on the plate-like member 38 may be any shape as long as the seal member 36 can rotate integrally with the plate-like member 38 and the needle hub 32.

<3. Third Embodiment>
Next, a third embodiment of the prefilled syringe applied as the drug injection device of the present invention will be described with reference to FIGS.
FIG. 7 is a cross-sectional view showing a state before use of the prefilled syringe according to the third embodiment, and FIG. 8 is a cross-sectional view showing a state in use. FIG. 9 is an enlarged cross-sectional view showing a main part of FIG.

  The prefilled syringe 51 according to the third embodiment differs from the prefilled syringe 1 according to the first embodiment in the configuration of the inflow channel securing means and the needle hub. Therefore, here, the inflow channel securing means and the needle hub will be described, and the same reference numerals are assigned to the portions common to the prefilled syringe 1 according to the first embodiment, and redundant description will be omitted.

  As shown in FIG. 7, the needle hub 52 has an insertion portion 53 and a holding portion 54. A substantially cylindrical convex portion 55 is formed on the opposing surface 53 b of the insertion portion 53 that faces the distal end surface 12 b of the discharge portion 12. This convex part 55 protrudes toward the front end surface 12b side of the discharge part 12 from the opposing surface 53b. And the cylindrical hole of this convex part 55 comprises the inflow port 56 which flows the chemical | medical agent M into the needle tube 3. FIG.

  The inflow channel securing means 57 is configured as a coil spring 58. The coil spring 58 is disposed so as to cover the outer periphery of the convex portion 55 provided in the insertion portion 53. One end of the coil spring 58 is fixed to the facing surface 53 b of the insertion portion 53, and the other end is fixed to the seal member 6.

  The seal member 6 is disposed in a space S formed by the insertion portion 53 and the distal end surface 12 b of the discharge portion 12. Specifically, the seal member 6 is disposed between the distal end surface 12b of the discharge portion 12 and the opposing surface 53b of the needle hub 52, and the end portion of the convex portion 55 protruding from the distal end surface 12b and the opposing surface 53b. It is pinched by. The seal member 6 is in liquid-tight contact with the distal end surface 12b of the discharge portion 12 and seals the medicine M in the outer cylinder 2 (first state).

  As shown in FIG. 8, when the distance between the facing surface 53 b of the needle hub 52 and the distal end surface 12 b of the discharge portion 12 is more than the thickness of the seal member 6, the seal member 6 is held between the needle hub 52 and the outer cylinder 2. Canceled. Thereby, the seal member 6 is separated from the distal end surface 12b of the discharge portion 12, and the liquid tightness of the outer cylinder 2 by the seal member 6 is released (second state).

  Here, since the seal member 6 is pushed out by the water pressure of the medicine M, the distance T between the seal member 6 and the distal end surface 12b of the discharge portion 12 increases, and the distance P between the seal member 6 and the end portion of the convex portion 55 is increased. Narrow. Then, the seal member 6 may block the inlet 56 of the needle hub 52, that is, the cylindrical hole of the convex portion 55.

  However, in the third embodiment, a coil spring 58 is provided in the insertion portion 53 as the inflow passage securing means 57. The coil spring 58 urges the seal member 6 toward the distal end surface 12b side of the discharge portion 12. Therefore, the seal member 6 is brought into a floating state between the distal end surface 12b of the discharge portion 12 and the end portion of the convex portion 55 by the biasing force of the coil spring 56 and the water pressure of the medicine M. As a result, the sealing member 6 can be prevented from blocking the inflow port 56.

  Other configurations are the same as those of the prefilled syringe 1 according to the above-described first embodiment, and thus description thereof is omitted. Also with the prefilled syringe 51 having such a configuration, the same operations and effects as those of the prefilled syringe 1 according to the first embodiment described above can be obtained.

<4. Fourth Embodiment>
Next, with reference to FIG. 10, the 4th Embodiment of the prefilled syringe applied as a chemical | medical agent injection apparatus of this invention is demonstrated.
FIG. 10 is an enlarged cross-sectional view showing a main part of the prefilled syringe according to the fourth embodiment.

  The prefilled syringe 71 according to the fourth embodiment is obtained by changing the shape of the discharge port of the discharge unit 12 of the prefilled syringe 51 according to the third embodiment. Therefore, here, the discharge unit will be described, and the same reference numerals are given to the same parts as those of the prefilled syringe 1 according to the first embodiment and the prefilled syringe 51 according to the third embodiment, and overlapped. The description that has been made will be omitted.

  As shown in FIG. 10, the discharge port 72a formed in the discharge part 72 is formed so as to be shifted from the center of the shaft to one side. The discharge port 72 a is arranged so as to be shifted from the center of the shaft of the seal member 6. Therefore, in the prefilled syringe 71 according to the fourth embodiment, the medicine M is discharged while being biased to one side with respect to the surface of the seal member 6. As a result, since the seal member 6 is inclined in the space S, the inflow port 56 can be prevented from being blocked by the seal member 6.

  Other configurations are the same as those of the prefilled syringe 1 according to the above-described first embodiment, and thus description thereof is omitted. Also with the prefilled syringe 71 having such a configuration, the same operations and effects as those of the prefilled syringe 1 according to the first embodiment described above can be obtained.

<Fifth Embodiment>
Next, with reference to FIG.11 and FIG.12, the 5th Embodiment of the prefilled syringe applied as a chemical | medical agent injection apparatus of this invention is described.
FIG. 11: is sectional drawing which shows the state before use of the prefilled syringe concerning 5th Example, FIG. 12 is sectional drawing which shows the state at the time of use.

  The prefilled syringe 81 according to the fifth embodiment differs from the prefilled syringe 1 according to the first embodiment in the configuration of the seal member and the configuration of the flow path through which the drug M passes. Therefore, here, the seal member and the flow path will be described, and the same reference numerals are given to the portions common to the prefilled syringe 1 according to the first embodiment, and redundant description will be omitted.

  As shown in FIG. 11, the seal member 86 is formed in a substantially cylindrical shape, and a through hole 86a is formed along the axial direction thereof. The through hole 86 a is continuously provided from the end surface on the discharge portion 12 side of the seal member 86 to the end surface on the facing surface 18 b side of the needle hub 4. The seal member 86 connects the distal end surface 12b side of the discharge portion 12 and the opposing surface 18b side of the needle hub 4 by a through hole 86a.

  When the seal member 86 is in the first state, the opening on the needle hub 4 side of the through hole 86 a is sealed by the plate-like member 23 that is the inflow passage securing means 7. Thereby, it can prevent that the chemical | medical agent M leaks from the outer cylinder 2 in the state before use. In addition, although the example which seals the opening by the side of the needle hub 4 of the through-hole 86a with the inflow path securing means 7 was demonstrated, when the inflow path securing means 7 is not provided, the opening by the side of the needle hub 4 of the through-hole 86a is The needle hub 4 is sealed by the facing surface 18b.

  As shown in FIG. 12, when the needle hub 4 is moved so that the distance between the facing surface 18b of the needle hub 4 and the distal end surface 12b of the discharge portion 12 is more than the thickness of the seal member 6, the needle hub 4 and The holding of the seal member 86 by the outer cylinder 2 is released. Then, the inflow channel securing means 7 is separated from the seal member 86. Here, the inflow path securing means 7 may be fixed to the insertion portion 18 of the needle hub 4 in order to smoothly separate the inflow path securing means 7 from the seal member 86.

  As a result, the opening on the needle hub 4 side of the through hole 86a in the seal member 86 is released. Therefore, the needle tube 3 and the discharge portion 12 communicate with each other through the through hole 86a of the seal member 86. The state of the seal member 86 at this time is the second state.

  Other configurations are the same as those of the prefilled syringe 1 according to the above-described first embodiment, and thus description thereof is omitted. Also with the prefilled syringe 81 having such a configuration, the same operations and effects as those of the prefilled syringe 1 according to the first embodiment described above can be obtained.

  In the prefilled syringe 81 according to the fifth embodiment, the seal member 86 may be fixed to the distal end surface 12b of the discharge unit 12.

<Sixth embodiment>
Next, with reference to FIG.13 and FIG.14, the 6th Embodiment of the prefilled syringe applied as a chemical | medical agent injection apparatus of this invention is described.
FIG. 13: is sectional drawing which shows the state before use of the prefilled syringe concerning the 6th embodiment, and FIG. 14 is sectional drawing which shows the state at the time of use.

  The prefilled syringe 91 according to the sixth embodiment is different from the prefilled syringe 1 according to the first embodiment in the configuration of the seal member and the flow path through which the drug M passes. Therefore, here, the seal member and the flow path will be described, and the same reference numerals are given to the portions common to the prefilled syringe 1 according to the first embodiment, and redundant description will be omitted.

  As shown in FIG. 13, the prefilled syringe 91 according to the sixth embodiment is not provided with an inflow channel securing means. The prefilled syringe 91 includes a holding portion 93 that holds the needle tube 3 and a needle hub 92 having an insertion portion 94. The insertion portion 94 is provided with an insertion hole 94a into which the discharge portion 12 is inserted.

  The seal member 96 is disposed in a space S formed by the insertion portion 94 and the distal end surface 12 b of the discharge portion 12. Further, the seal member 96 is formed in a substantially cylindrical shape, and a through hole 96a is formed along the axial direction thereof. The through hole 96 a is continuously provided from the end surface on the discharge portion 12 side of the seal member 86 to the end surface on the facing surface 94 b side of the needle hub 92.

  Further, in a state before use, the seal member 96 is compressed by the front end surface 12 b of the discharge portion 12 and the opposing surface 94 b of the insertion portion 94. The seal member 96 is compressed and deformed so that its shape spreads outward in the radial direction, and the through hole 96a is closed. As a result, the sealing member 96 is in liquid-tight contact with the distal end surface 12b of the discharge portion 12 and the through hole 96a is closed, so that the chemical solution M does not leak from the outer cylinder 2. This state of the seal member 96 is the first state according to the fifth embodiment.

  As shown in FIG. 14, when the needle hub 92 is moved in the axial direction, the compression of the seal member 96 by the distal end surface 12b of the discharge portion 12 and the opposing surface 94b of the insertion portion 94 is released. Thereby, since the shape of the seal member 96 is restored, the closed state of the through hole 96a is released, and the chemical solution M can pass through the through hole 96a. As a result, the needle tube 3 and the discharge portion 12 communicate with each other through the through hole 96a of the seal member 96. The state of the seal member 96 at this time is the second state.

  Other configurations are the same as those of the prefilled syringe 1 according to the above-described first embodiment, and thus description thereof is omitted. Also with the prefilled syringe 91 having such a configuration, the same operations and effects as those of the prefilled syringe 1 according to the first embodiment described above can be obtained.

  Further, in the prefilled syringe 91 according to the sixth embodiment, the seal member 96 is fixed to the distal end surface 12b of the discharge section 12 in the same manner as the prefilled syringe 81 according to the fifth embodiment. Also good.

  The present invention is not limited to the embodiment described above and shown in the drawings, and various modifications can be made without departing from the scope of the invention described in the claims.

  DESCRIPTION OF SYMBOLS 1,31,51,71,81 ... Prefilled syringe (medicine injection apparatus), 2 ... Outer cylinder (storage container), 3 ... Needle tube, 3b ... Needle hole, 4, 32, 52, 92 ... Needle hub, 6,36 , 86, 96 ... sealing member, 7, 37, 57 ... inflow passage securing means, 12, 72 ... discharge part, 12a, 72a ... discharge port, 12b ... tip surface (tip), 13 ... screw part, 16 ... bulge Part (regulating means), 17, 33, 54, 93 ... holding part, 18, 34, 53, 94 ... insertion part, 18a, 34a, 53a, 94a ... insertion hole, 18b, 34b, 53b, 94b ... opposite surface, DESCRIPTION OF SYMBOLS 19 ... Screw groove, 21 ... Inner flange part (regulation means) 22, 56 ... Inlet, 23, 38 ... Plate-like member, 24, 39 ... Groove, 41, 41B ... Fixed part, 55 ... Convex part, 58 ... Coil springs 86a, 96a ... through holes ... space

Claims (6)

A storage container having a discharge part for storing the medicine and discharging the medicine;
A needle tube having a needle tip that can puncture a living body;
A needle hub having a holding portion for holding the needle tube and an insertion portion into which the discharge portion is inserted, and being movable in the axial direction of the discharge portion of the storage container;
A seal member disposed in a space formed by the distal end surface of the discharge portion and the insertion portion of the needle hub,
The seal member moves the needle hub in the axial direction so as to be in liquid-tight contact with the distal end surface of the discharge portion, and is separated from the distal end surface of the discharge portion and the needle tube The medicine injection device is characterized in that it changes to a second state in which a flow path through which the medicine is passed and the medicine passes is formed. An inflow path securing means for securing an inflow path through which the medicine passes is provided between the seal member and the facing surface of the needle hub facing the distal end surface of the discharge portion. The drug injection device according to claim 1. The drug injection device according to claim 2, wherein the inflow channel securing means is a plate-like member having a groove or a protrusion that forms an inflow channel through which the drug passes. A storage container having a discharge part for storing the medicine and discharging the medicine;
A needle tube having a needle tip that can puncture a living body;
A holding portion that holds the needle tube; and an insertion portion in which the discharge portion is inserted and an opposing surface that is opposed to the distal end surface of the discharge portion is formed, and is arranged in an axial direction of the discharge portion of the storage container A movable needle hub,
A through-hole is formed in the space formed by the distal end surface of the discharge portion and the insertion portion of the needle hub, and connects the distal end surface side of the discharge portion and the opposing surface side of the needle hub. A sealed member,
The seal member is configured to move the needle hub in the axial direction so as to be in liquid-tight contact with the distal end surface of the discharge portion and to close the through hole; and The drug injection device is changed to a second state in which the occlusion is released and the needle tube communicates with the discharge portion through the through-hole, and a flow path through which the drug passes is formed. . 5. The drug injection device according to claim 4, wherein, in the first state, the through hole is closed by compressing and deforming the seal member by the needle hub and the discharge portion. In the first state, the opening on the needle hub side of the through hole in the seal member is provided between the facing surface of the needle hub or between the facing surface of the needle hub and the sealing member, 6. The medicine injection device according to claim 4, wherein the medicine injection device is sealed by an inflow passage securing means for securing an inflow passage through which the medicine passes.

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