JP2011152211A - Guide wire - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a guide wire for improving slip performance on a guide wire distal end side, to improve selectivity of a tube-shaped organ at a branch part, and to increase hold power with respect to a tube on a guide wire basal end side. <P>SOLUTION: The guide wire 10 comprises a core line 20 and a resin film 40 coated on an outer periphery of the core line 20. The outer peripheral surface within a prescribed range along an axis direction from the guide wire distal end has a rugged shape, and a smooth surface 47 in which an outer peripheral surface from a basal end of the rugged-shaped outer peripheral surface 43 to the guide wire basal end is not rugged. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a guide wire used when a tube such as a catheter is inserted into a human tubular organ such as a blood vessel, a ureter, a bile duct, or a trachea.

  Conventionally, in order to inspect and treat human tubular organs such as blood vessels, ureters, bile ducts, and trachea, a tube-like catheter is inserted and a drug such as a contrast medium or an anticancer agent is administered, or tissue is removed by forceps through the catheter. Some of them are collected. When inserting the catheter, a relatively thin and flexible guide wire is inserted into the tubular organ, and the distal end of the guide wire reaches the target location, and then the catheter is inserted along the outer periphery of the guide wire. .

  As a conventional guide wire of this type, Patent Document 1 below discloses a guide wire in which the outer periphery of a core wire is covered with a resin film having at least a part of an uneven spiral pattern color-coded in a plurality of colors. In the embodiment, it is described that a resin film having an uneven spiral pattern is coated on the base side of the core wire.

  In the following Patent Document 2, a wire body having a core wire, a raised portion forming layer partially provided on the outer periphery of the wire body, and at least the raised portion forming layer and the raised portion forming layer in the formation region of the raised portion forming layer, and A portion of the outer surface of the guide wire that is provided with the raised portion forming layer is raised with respect to a portion that is not provided with the raised portion forming layer. A guide wire is disclosed. The raised portion forming layer is provided from the leading end to the proximal end of the core wire, and as a result, the outer periphery of the covering layer covering the raised portion forming layer and the wire body is uneven from the leading end to the proximal end of the guide wire. ing.

JP 2007-97662 A JP 2008-264498 A

  Since the distal end side of the guide wire of Patent Document 1 is not uneven, when the guide wire is inserted into the tubular organ from the distal end side, the contact area with the inner wall of the tubular organ on the distal end side of the guide wire is increased and the slip property is low. . As a result, there is a problem in the selectivity of the tubular organ because it is difficult to insert the tip of the guide wire into the target branch tube at the branch portion where a plurality of branch tubes branch.

  Also, when a tube such as a catheter or sheath is inserted into a tubular organ through a guide wire, the tube is moved along the outer periphery of the guide wire with the tip of the guide wire previously placed at the target location of the tubular organ. To go. In this case, while holding and fixing the base side of the guide wire with one hand, hold the tube with the other hand and operate it. Sometimes you want to.

  However, since the guide wires of Patent Documents 1 and 2 are both uneven on the base side, the contact area of the guide wire with respect to the inner periphery of the tube is small, and the guide wire is easy to slide with respect to the tube. Therefore, when the hand is released from the guide wire or the tube, the guide wire moves with respect to the tube, and the guide wire placed at the target position may be displaced. In this case, the position of the guide wire must be corrected again, resulting in trouble with workability.

  Accordingly, an object of the present invention is to improve the sliding property of the guide wire at the distal end side in the insertion direction into the tubular organ, to improve the selectivity of the tubular organ at the branch portion, and to the tube at the guide wire base side. It is to provide a guide wire that increases the holding force against the.

  In order to achieve the above object, one of the present invention is a guide wire comprising a core wire and a resin film coated on the outer periphery of the core wire, the outer periphery having a predetermined range along the axial direction from the tip of the guide wire. The surface is uneven, and the outer peripheral surface from the proximal end of the uneven outer peripheral surface to the guide wire proximal end is a smooth surface without unevenness.

  In one guide wire of the present invention, the core wire has a base portion and a reduced diameter portion that is reduced in diameter from the base portion toward the tip of the guide wire, and the resin film has a reduced diameter portion of the core wire. A concavo-convex resin film having a concavo-convex outer peripheral surface covering the middle or a portion reaching the distal end side of the base, and a smooth resin film covering from the base end of the concavo-convex resin film to the base end of the base of the core wire It is preferable to have.

  Another aspect of the present invention is a guide wire composed of a core wire and a resin film coated on the outer periphery of the core wire, and the outer peripheral surface in a predetermined range along the axial direction from both ends of the guide wire is uneven. The outer peripheral surface located between these uneven | corrugated outer peripheral surfaces has comprised the smooth surface without an unevenness | corrugation, It is characterized by the above-mentioned.

  In another guide wire of the present invention, the core wire has a reduced diameter portion whose both ends are reduced in diameter, and a portion between the reduced diameter portions forms a base portion thicker than the reduced diameter portion, The resin film covers a portion from the both ends of the core wire to the middle of the reduced diameter portion or the end portion side of the base portion, and between the uneven resin film having the uneven outer peripheral surface and the uneven resin film. It is preferable to have a smooth resin film covering the portion.

  In the guide wire of the present invention, it is preferable that the concavo-convex resin film is subjected to a hydrophilic treatment, and the smooth resin film is subjected to a water repellency treatment.

  The guide wire of the present invention is preferably used when inserted into a blood vessel.

  According to the present invention, the outer peripheral surface of the predetermined range along the axial direction from the distal end of the guide wire or the outer peripheral surface of the predetermined range along the axial direction from both ends of the guide wire has an uneven shape. When the guide wire is inserted into the tubular organ, the friction area can be reduced by reducing the contact area of the guide wire with respect to the inner wall of the tubular organ on the distal side in the insertion direction of the tubular organ, and the sliding property on the distal side of the guide wire It is possible to smoothly move the tubular organ. In addition, since the guide wire has good slidability, it can be easily inserted into a desired branch tube at a branch portion where a plurality of branch tubes are branched, and the selectivity of the tubular organ at the branch portion is improved.

  Furthermore, when the outer peripheral surface in a predetermined range along the axial direction from the distal end of the guide wire is uneven, the outer peripheral surface from the proximal end of the uneven peripheral surface to the proximal end of the guide wire, or both ends of the guide wire When the outer peripheral surface of the predetermined range along the axial direction is uneven, the outer peripheral surface located between the uneven outer peripheral surfaces is a smooth surface without unevenness. The contact area of the base portion of the guide wire with respect to the inner periphery of a tube such as an inserted catheter is increased. As a result, the frictional force between the outer periphery of the base of the guide wire and the inner periphery of the tube increases, and even if the hand is released from the guide wire, the guide wire is less likely to be displaced with respect to the tube and held in place. be able to.

It is a section explanatory view showing one embodiment of a guide wire of the present invention. It is a side view of the guide wire. The other shape of the uneven | corrugated outer peripheral surface in the same guide wire is shown, (a) is explanatory drawing at the time of providing a cyclic | annular convex part at predetermined intervals in an axial direction, (b) provides the protrusion extended in an axial direction. (C) is a cross-sectional view taken along the line AA in (b), (d) is an explanatory view when annular protrusions are provided at predetermined intervals in the axial direction on the outer periphery of the core wire, e) It is explanatory drawing at the time of providing a circular ditch | groove in the axial direction at predetermined intervals on the outer periphery of a core wire. The use state of the guide wire is shown, (a) is an explanatory view showing the state at the branching portion, and (b) is an explanatory view showing the state at the guide wire hand side. It is a section explanatory view showing other embodiments of the guide wire of the present invention.

  Hereinafter, an embodiment of a guide wire of the present invention will be described with reference to the drawings.

  As shown in FIGS. 1 and 2, the guide wire 10 in this embodiment includes a core wire 20 having a reduced diameter portion 23 on the distal end side, a coil 30 attached to the outer periphery of the reduced diameter portion 23 of the core wire 20, and A resin film 40 is provided on the outer periphery of the core wire 20 and the outer periphery of the coil 30. As shown in FIG. 2, a predetermined range of the outer peripheral surface along the axial direction from the distal end of the guide wire forms an uneven outer peripheral surface 43, and the outer peripheral surface from the proximal end of this uneven outer peripheral surface 43 to the proximal end of the guide wire Forms a smooth surface 47 with no irregularities. In the following description, the base portion of the guide wire means a portion having a smooth surface 47 without unevenness.

  As shown in FIG. 1, the core wire 20 includes a base portion 21 extending at a predetermined length with a constant diameter, a tapered portion 24 extending while being gradually reduced in diameter from the distal end of the base portion 21 toward the distal end of the guide wire, and the same tapered portion. And a small-diameter portion 25 extending linearly from the tip of 24 with a constant diameter. The tapered portion 24 and the small diameter portion 25 form the reduced diameter portion 23 in the present invention. The diameter-reduced portion 23 may have a tapered shape in which the entire diameter gradually decreases toward the tip, or may have a stepped shape by gradually reducing the diameter toward the tip, and is not particularly limited. .

  Examples of the material of the core wire 20 include a Ni—Ti alloy, a Ni—Ti—X (X = Fe, Cu, V, Co, etc.) alloy, a Cu—Zn—X (X = Al, Fe, etc.) alloy, and the like. A superelastic alloy, or stainless steel, piano wire, and X-ray opaque material made of Pt, Ti, Pd, Rh, Au, W, Ag, Bi, Ta, and alloys thereof are preferably used.

  The coil 30 attached to the outer periphery of the reduced diameter portion 23 of the core wire 20 includes, for example, a Ni—Ti alloy, a Ni—Ti—X (X = Fe, Cu, V, Co, etc.) alloy, Cu—Zn—X ( X = Al, Fe, etc.) Super elastic alloy such as an alloy, or stainless steel, piano wire, X-ray made of Pt, Ti, Pd, Rh, Au, W, Ag, Bi, Ta and alloys thereof It is formed by winding a metal wire made of an impermeable material.

  In the coil 30 of this embodiment, the base side is a tightly wound portion 31 in which wires are closely wound, and the pushability can be maintained, and the distal end side is a coarsely wound portion 33 having a gap between the wires. It is possible to ensure sex.

  Then, the reduced diameter portion 23 of the core wire 20 is inserted into the inner periphery of the coil 30, and the proximal end of the densely wound portion 31 is fixed to the outer periphery of the tapered portion 24 via a joint portion 35 made of a brazing material. Is fixed to the tip of the small-diameter portion 25 via a round head portion 36 made of brazing material, and an adhesive 37 is filled in the gap between the inner periphery of the coil 30 and the outer periphery of the core wire 20. The coil 30 is mounted on the outer periphery of the reduced diameter portion 23.

  A resin film 40 is coated on the entire outer periphery of the core wire 20 and the outer periphery of the coil 30 to which the reduced diameter portion 23 of the concentric wire 20 is attached. The resin film 40 in this embodiment covers an uneven resin film 41 that covers a portion from the distal end of the core wire 20 to the distal end side of the base portion 21, and covers from the proximal end of the uneven resin film 41 to the proximal end of the core wire 20. And a smooth resin film 45.

  The concavo-convex resin film 41 of this embodiment has a bottomed cylindrical tube shape in which the distal end portion 41a is closed and the proximal end side is opened. Here, it extends so as to be able to cover from the forefront of the core wire 20 to the portion extending beyond the tapered portion 24 of the reduced diameter portion 23 to the tip side of the base portion 21. Further, the distal end portion 41a has a tapered shape with a rounded tip, thereby enhancing insertion into a tubular organ.

  The uneven resin film 41 is made of, for example, polyurethane, nylon elastomer, polyether block amide, polyethylene, polyvinyl chloride, vinyl acetate, polytetrafluoroethylene (PTFE), perfluoroalkoxy resin (PFA), four Fluorine resins such as fluorinated ethylene-hexafluoropropylene copolymer (FEP) and tetrafluoroethylene-ethylene copolymer (ETFE) can be preferably used. Moreover, it is preferable that the outer periphery of the concavo-convex resin film 41 is subjected to a hydrophilic treatment in which a hydrophilic resin such as polyvinyl pyrrolidone, polyethylene glycol, or methyl vinyl ether maleic anhydride copolymer is coated.

  As shown in FIGS. 1 and 2, convex portions 43 a are spirally provided on the outer periphery of the concavo-convex resin film 41 at a predetermined pitch P along the axial direction, thereby adjacent convex portions. 43a and 43a form a spiral concave portion 43b, and these convex portions 43a and concave portions 43b are alternately and continuously arranged in the axial direction of the outer periphery of the concave-convex resin film 41 to form a spiral concave-convex outer periphery. A surface 43 is formed. As a result, the contact area of the distal end side of the guide wire with the inner wall of the tubular organ is reduced, so that the frictional resistance can be reduced and the slipperiness can be improved.

  As shown in FIG. 1, in this embodiment, the predetermined range along the axial direction from the distal end portion 41a of the concavo-convex resin film 41 is not uneven but is formed smoothly, and the base end of this smooth portion Accordingly, an uneven outer peripheral surface 43 is formed in a predetermined range along the axial direction of the uneven resin film 41 (this range is referred to as an uneven surface forming range L). The uneven surface forming range L is preferably 30 to 200 mm. If the uneven surface forming range L is within the above range, the length of the uneven outer peripheral surface 43 on the guide wire distal end side and the length of the smooth surface 47 on the guide wire base side are secured in a well-balanced manner. Both the sliding property on the side and the holding force for the tube on the guide wire base side can be enhanced. In addition, when the uneven surface formation range L is less than 30 mm, it is difficult to ensure slipperiness on the distal end side of the guide wire, and when it exceeds 200 mm, the smooth surface 47 is shortened and it is difficult to ensure the holding force for the tube.

  In addition, as shown in the partial enlarged view of FIG. 2, the pitch P between adjacent convex parts 43a and 43b is preferably 0.5 mm or more, more preferably 0.5 to 2 mm, and 1 to 1.5 mm. Most preferably. When the pitch P is 0.5 mm or more, the adjacent convex portions 43a and 43a are separated from each other at an appropriate interval. Since the convex portions 43a and 43a are too close to each other, the concave and convex portions are easily caught on the inner wall of the tubular organ, and the slipperiness is lowered.

  Further, the height difference D between the convex portion 43a and the concave portion 43b forming the concave / convex outer peripheral surface 43 (from the portion of the convex portion 43a that protrudes most in the guide wire outer diameter direction to the concave portion 43b that is most concave in the guide wire inner diameter direction). The distance to the heel portion) is preferably 0.01 to 0.05 mm, and more preferably 0.01 to 0.02 mm. If the height difference D is less than 0.01 mm, the effect of improving slipperiness cannot be expected, and if it exceeds 0.05 mm, the outer diameter of the guide wire 10 is increased, resulting in a loss of flexibility. If the height difference D is 0.01 to 0.05 mm, the outer diameter of the guide wire 10 is made as small as possible, and the sliding property on the distal end side of the guide wire with respect to the tubular organ is effectively reduced within a range that does not impair flexibility. Can be improved.

  Moreover, as shown in FIG. 1, it is preferable that the thickness T (projection height from the outer peripheral surface of the base 21 of the core wire 20) of the uneven resin film 41 is 0.09 mm or more. If the thickness T is 0.09 mm or more, the unevenness as described above is formed on the outer peripheral surface of the uneven resin film 41 without being affected by the shape of the coil 30 disposed on the inner periphery of the uneven resin film 41. The outer peripheral surface 43 can be formed.

  The concave / convex outer peripheral surface 43 is not limited to the one formed by providing spiral convex portions 43a and concave portions 43b on the outer periphery of the concave / convex resin film 41. For example, as shown in FIG. 3A, the concave / convex outer peripheral surface 43 may be formed on the outer periphery of the concave / convex resin film 41 by providing annular convex portions 43c at predetermined intervals along the axial direction. . Further, as shown in FIGS. 3B and 3C, the protrusions 43 d that extend along the axial direction are projected evenly on the outer periphery of the uneven outer peripheral surface 43 at predetermined intervals, thereby forming an uneven shape. The outer peripheral surface 43 may be formed.

  Further, in the above-described embodiment, the concave / convex outer peripheral surface 43 is directly provided on the concave / convex resin film 41 itself. However, the present invention is not limited to this, and by providing the core wire 20 with the concave / convex outer periphery 43 The surface 43 may be formed indirectly. For example, as shown in FIG. 3 (d), when the annular protrusions 27 are provided on the outer periphery of the core wire 20 at predetermined intervals along the axial direction and the uneven resin film 41 is adhered and covered thereto, the protrusions The concavo-convex resin film 41 swells along the protruding shape of the portion 27, and the concavo-convex outer peripheral surface 43 can be formed on the outer periphery thereof. Further, as shown in FIG. 3 (e), when the concave grooves 28 are provided on the outer periphery of the core wire 20 at predetermined intervals along the axial direction, and the concave-convex resin film 41 is adhered and covered thereto, the concave grooves 28 are formed. The concave / convex outer peripheral surface 43 can be formed on the outer periphery of the concave / convex resin film 41 entering the groove 28 and being recessed.

  On the other hand, the smooth resin film 45 covering from the base end of the concavo-convex resin film 41 to the base end of the core wire 20 forms a smooth surface 47 without any concavo-convex on the outer periphery. In this embodiment, the front end side is open. At the same time, it has a bottomed cylindrical tube shape whose base end is closed.

  The material is, for example, polytetrafluoroethylene (PTFE), perfluoroalkoxy resin (PFA), tetrafluoroethylene-hexafluoropropylene copolymer (FEP), tetrafluoroethylene-ethylene copolymer (ETFE). Or a synthetic resin such as polyurethane, nylon elastomer, polyether block amide, polyethylene, polyvinyl chloride, or vinyl acetate is preferably used. Further, it is preferable that the outer periphery of the smooth resin film 45 is subjected to a water repellent treatment in which a water repellent resin such as a silicon resin or a fluorine resin is coated.

  In this embodiment, the coil 30 is attached to the outer periphery of the tip end of the core wire 20. However, the present invention is not limited to this, and the entire core wire 30 is not attached to the outer periphery of the tip end of the core wire 30. The guide wire according to the present invention may be configured by covering with.

  The guide wire 10 described above can be manufactured as follows, for example.

  First, a method for manufacturing the concavo-convex resin film 41 having a spiral concavo-convex shape as shown in FIGS. That is, a core material for tube molding is set in a hole of a molding die of a molding device (not shown), and this core material is passed through the hole of the molding die and pulled out from the hole at a predetermined speed, and a molten resin is formed on the outer periphery of the core material. By adhering, a tubular resin film is formed.

  At this time, by increasing the supply pressure when supplying the molten resin, higher than the general supply pressure, and by pulling out the core material from the hole of the molding die at a higher speed than the general extraction speed, A resin film having a concavo-convex outer peripheral surface 43 can be formed on the outer periphery of the core material. Finally, the tubular concavo-convex resin film 41 can be manufactured by pulling out the core material from the resin film.

  Further, the core wire 20 including the base portion 21, the taper portion 24, and the narrow diameter portion 25 is formed by appropriately machining or etching the strand having a predetermined diameter cut out by a predetermined length. Next, the coil 30 is attached to the outer periphery of the reduced diameter portion 23 of the core wire 20 by fixing the coil 30 to a predetermined portion of the core wire 20 through the joint portion 35 and the head portion 36 made of brazing material.

  Then, the smooth resin film 45 is coated on the outer periphery of the proximal side (base side), which is a portion to be gripped by the guide wire 10, and the uneven resin film 41 is formed on the outer periphery of the core wire 20 and the coil 30 on the distal end side of the guide wire 10. Cover.

  The coating of the concavo-convex resin film 41 and the smooth resin film 45 can be coated by, for example, pultrusion molding, or can be covered with a resin tube and fixed with an adhesive, and when it is made of a heat-shrinkable tube such as urethane. It is also possible to heat shrink by heating it with a heating means such as a heater after covering it on the outer periphery of the core wire 20 or the coil 30. In the case of a tube made of fluororesin or the like, a solvent such as methyl ethyl ketone (MEK) It is also possible to swell in advance and cover it on the outer periphery of the core wire 20 or the coil 30, and then to dry and shrink the solvent.

  In this embodiment, the smooth upper resin film 45 on the base end side is covered with a swelled beforehand by a solvent, covered with the outer periphery of the core wire 20, and then dried and contracted to form a concavo-convex shape on the front end side. The resin film 41 is covered by being fixed to the outer periphery of the core wire 20 and the coil 30 on the distal end side of the guide wire 10 via an adhesive 37. In this way, the guide wire 10 as shown in FIGS. 1 and 2 can be manufactured.

  The guide wire 10 thus obtained can be used, for example, when a medical tube such as a catheter or a sheath is guided to a target location of a tubular organ not shown in the well-known Seldinger method.

  This will be referred to with reference to FIGS. FIG. 4A is an explanatory view when a guide wire is inserted into a tubular organ, and in particular, in a branch portion V where a plurality of branch tubes V1 and V2 are branched, the guide is guided to the target branch tube. The state at the time of inserting the front-end | tip part of the wire 10 is shown. FIG. 4B shows a state on the proximal side (base side) of the guide wire 10 when the tube T is inserted along the guide wire 10.

  That is, the guide wire 10 is inserted into the tubular organ through the skin through a puncture needle or a sheath-like sheath. At this time, in this guide wire 10, the predetermined range along the axial direction from the distal end of the guide wire forms the concave / convex outer peripheral surface 43. Therefore, the tubular organ on the distal end side in the insertion direction of the guide wire 10 into the tubular organ. The frictional resistance can be reduced by reducing the contact area with the inner wall, the sliding property of the guide wire tip side can be improved, and the tubular organ can be moved smoothly.

  As described above, since the guide wire 10 has a good sliding property at the distal end side in the insertion direction into the tubular organ, the effect is particularly exerted at the branch portion V as shown in FIG. That is, after the distal end of the guide wire 10 reaches the branch portion V where the plurality of branch pipes V1 and V2 branch, the proximal side of the guide wire 10 is gripped and rotated so that the distal end portion of the guide wire 10 is in a predetermined direction. Rotate to select the target branch pipe (here, V1). Then, the guide wire 10 is inserted into the branch pipe V1. At this time, by providing the concavo-convex outer peripheral surface 43 as described above, the guide wire 10 is inserted at the distal end side in the insertion direction into the tubular organ. Therefore, the tube can be smoothly inserted into the desired branch pipe V1, and as a result, the selectivity of the tubular organ at the branch portion V can be improved.

  On the other hand, since the outer peripheral surface of the guide wire 10 from the base end of the concave / convex outer peripheral surface 43 to the guide wire base end forms a smooth surface 47 having no concave / convex portions, as shown in FIG. The outer circumference of the proximal side of the guide wire 10 is likely to come into contact with the inner circumference of the tube T inserted along the outer circumference of the wire, and the contact area of the proximal portion of the proximal side of the guide wire 10 with respect to the inner circumference of the tube T is increased. It becomes. As a result, the frictional force between the outer periphery of the base of the guide wire 10 and the inner periphery of the tube T can be increased, so that the holding force with respect to the tube T at the base of the guide wire is improved. Even if the guide wire 10 is released, the guide wire 10 is not easily displaced with respect to the tube T, and the guide wire 10 can be held at a predetermined position. Therefore, the work for correcting the position of the guide wire 10 that is necessary when the position of the guide wire 10 is displaced becomes unnecessary, and workability can be improved.

  In this embodiment, the resin film 40 is composed of a concavo-convex resin film 41 having a concavo-convex outer peripheral surface 43 and a smooth resin film 45. As a result, the slippery resin film 41 can improve the slidability of the guide wire tip side, and the smooth resin film 43 can increase the holding force of the guide wire 10 against the tube T. In addition, since the resin film 40 is divided into the concavo-convex resin film 41 and the smooth resin film 45, the concavo-convex resin film 41 having the concavo-convex outer peripheral surface 43 and having a complicated shape is formed on the entire core wire 20. The manufacturing cost can be reduced because it is not necessary to form with a covering length and it is sufficient to form a part with a short length.

  Furthermore, in this embodiment, the uneven resin film 41 is subjected to a hydrophilic treatment, and the smooth resin film 45 is subjected to a water repellent treatment. As described above, the hydrophilic treatment of the concavo-convex resin film 41 can further improve the slipping property of the guide wire on the distal side in the insertion direction into the tubular organ. Further, since it is possible to grip and rotate by hand without attaching a gripping tool to the proximal end portion of the guide wire 10, the operation of the guide wire 10 when selecting a desired branch pipe in the branch portion V is possible. Can be improved. On the other hand, since the smooth resin film 45 has been subjected to water repellency treatment, the base resin on the proximal side of the guide wire can be prevented from being peeled off by a liquid such as a chemical solution or a contrast medium. Stable operability can be obtained by preventing slipping due to the peeled resin.

  In this embodiment, the guide wire 10 is preferably used when inserted into a blood vessel. According to this, a desired branch pipe can be selected more effectively in guide wire insertion work into a blood vessel having many fine branch pipes.

  FIG. 5 shows another embodiment of the guide wire of the present invention. Note that substantially the same parts as those of the above-described embodiment are denoted by the same reference numerals, and description thereof is omitted.

  In the guide wire 10a in this embodiment, the outer peripheral surface of the predetermined range along the axial direction from both ends of the guide wire forms the concave / convex outer peripheral surface 43, and the outer peripheral surface located between the two concave / convex outer peripheral surfaces 43, 43 is uneven. A smooth surface 47 having no surface is formed. In addition, the base part of the guide wire in this embodiment means the part which made the smooth surface 47 between the uneven | corrugated outer peripheral surfaces 43 and 43. FIG.

  As shown in FIG. 5, the core wire 20a has reduced diameter portions 23a and 23b whose both ends are reduced in diameter, and the portion between these reduced diameter portions 23a and 23b is more than the reduced diameter portions 23a and 23b. A thick base 21a is formed. Both the reduced diameter portions 23a and 23b are composed of a taper portion 24 and a small diameter portion 25 as in the above-described embodiment, and coils 30 are mounted on the outer periphery thereof.

  The outer periphery of the core wire 20a and the outer periphery of both the coils 30 and 30 are covered with the resin film 40. The resin film 40a in this embodiment covers the portions extending from both ends of the core wire 20a to the end portion side of the base portion 21a, and the concavo-convex resin films 41 and 41 having the concavo-convex outer peripheral surface 43, and the concavo-convex resin film 41. , 41 and a smooth resin film 45 covering the portion between them.

  In this embodiment, the maximum outer diameters Da and Db of the reduced diameter portions 23a and 23b of the core wire 20a are the same, and the lengths La and Lb along the axial direction are also the same. However, the present invention is not limited to this. For example, (1) the maximum outer diameters Da and Da of the reduced diameter portions 23a and 23b are set to different outer diameters, while the lengths La and Lb are the same length, or (2 ) While the lengths La and Lb of the reduced diameter portions 23a and 23b are different lengths, the maximum outer diameter Da and Db are the same outer diameter, or (3) the lengths La and Lb of the reduced diameter portions 23a and 23b are the same. On the other hand, the maximum outer diameters Da and Db may be different outer diameters.

  In the case of the above-described forms (1) to (3), the end to be used is appropriately selected according to the application location of the guide wire, such as when inserting into a blood vessel having a thin inner diameter or a digestive tract having a relatively large inner diameter. It is possible to improve the convenience for the user.

DESCRIPTION OF SYMBOLS 10 Guide wire 20 Core wire 21 Base 23 Reduced diameter part 40 Resin film 41 Uneven resin film 43 Uneven outer peripheral surface 45 Smooth resin film 47 Smooth surface

Claims (6)

A guide wire composed of a core wire and a resin film coated on the outer periphery of the core wire,
The outer peripheral surface in a predetermined range along the axial direction from the distal end of the guide wire has an uneven shape, and the outer peripheral surface from the proximal end of the uneven outer peripheral surface to the proximal end of the guide wire has a smooth surface without unevenness. Feature guide wire. The core wire has a base, and a reduced diameter portion reduced in diameter from the base toward the tip of the guide wire,
The resin film covers a portion extending from the tip of the core wire to the middle of the reduced diameter portion or the tip of the base, and has an uneven resin film having the uneven outer peripheral surface, and a base end of the uneven resin film The guide wire according to claim 1, further comprising: a smooth resin film covering from a base end to a base end of the base portion of the core wire. A guide wire composed of a core wire and a resin film coated on the outer periphery of the core wire,
A guide characterized in that an outer peripheral surface in a predetermined range along the axial direction from both ends of the guide wire has an uneven shape, and an outer peripheral surface located between the uneven outer peripheral surfaces forms a smooth surface without unevenness. Wire. The core wire has a reduced diameter part whose both ends are reduced in diameter, and a part between the reduced diameter parts forms a base part thicker than the reduced diameter part,
The resin film covers a portion from the both ends of the core wire to the middle of the reduced diameter portion or the end portion side of the base portion, and between the uneven resin film having the uneven outer peripheral surface and the uneven resin film. The guide wire according to claim 3, further comprising a smooth resin film covering the portion.   The guide wire according to any one of claims 1 to 4, wherein the concavo-convex resin film is subjected to a hydrophilic treatment, and the smooth resin film is subjected to a water repellency treatment.   The guide wire according to any one of claims 1 to 5, which is used when inserted into a blood vessel.