JP2011032171A - Skin whitening composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a composition having an excellent skin whitening effect. <P>SOLUTION: The skin whitening composition includes component (A) of astaxanthin and component (B) of at least one kind selected from cysteine and a derivative thereof, glutathione and a derivative thereof, tranexamic acid and a derivative thereof, arbutin and a derivative thereof, hydroquinone and a derivative thereof, ascorbic acid and a derivative thereof, ellagic acid and a derivative thereof, resorcinol and a derivative thereof, an endothelin antagonist, a placenta extract, a plant extract, a molasses extract, a yeast extract, a microorganism fermentation metabolite, citric acid, lactic acid, tartaric acid, malic acid, glycolic acid, succinic acid, vitamin E and a derivative thereof, vitamin B and a derivative thereof, vitamin A and a derivative thereof, an amino acid and a derivative thereof, a carotenoid, a polyphenol, titanium oxide, zinc oxide, olive oil, Pashikku oil, sunflower oil, jojoba oil and the like. A drug, a skin external preparation or a food and drink product which contains the skin whitening composition is also provided. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a whitening composition having an excellent whitening effect containing astaxanthin and a conventional whitening agent. More specifically, astaxanthin alone or a conventional whitening agent alone has a certain amount of whitening effect, but by combining them, the effect is further enhanced and the present invention relates to a whitening composition having an excellent whitening effect. Moreover, it is related with the pharmaceutical containing the composition for whitening, the skin external preparation, and food and drink.

  So far, vitamin Cs, glutathione, hydroquinone and derivatives thereof, placenta extract, plant extract and the like have been used as whitening agents. However, there are problems such as insufficient whitening effect and safety.

Astaxanthin is one of the same carotenoids as β-carotene, and is widely distributed in nature, especially in the ocean, including crustaceans such as shrimp and crabs, fish such as salmon and Thailand, algae such as the green alga Hematococcus, and yeasts such as the red yeast Phaffia. It is a food-rich red pigment. As for the whitening effect of astaxanthin, a pigmentation inhibitory action for external use (Non-Patent Document 1) and an in vitro melanin production inhibitory action (Non-Patent Document 2) have been reported, but the actual whitening effect is sufficient. That's not true.

Fragrance Journal, 14, 180-185, 2001 Carotenoid Science, 5, 21-24, 2002

  The subject of this invention is providing the whitening composition which has the outstanding whitening effect, the pharmaceutical containing the composition for whitening, the skin external preparation, food and drink, and methods for using them.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that by combining astaxanthin and a conventional whitening agent, those effects are further enhanced and an excellent whitening effect can be obtained. The present invention is based on such knowledge.

  By using the whitening composition of the present invention in the form of pharmaceuticals, external preparations for skin and foods and drinks, an effective whitening effect can be exhibited.

The composition of the present invention contains astaxanthin as the component (A). Astaxanthin means a product derived from a natural product or obtained by synthesis. Examples of those derived from natural products include microalgae such as the green alga Hematococcus, yeasts such as the red yeast Phaffia, crustacean shells such as shrimp, krill and crabs, craniopod viscera such as squid and octopus, various Adonis genus petals, such as seafood skin and fins of the seafood, Paracoccus sp. N81106, Brevundimonas sp. SD212, Erythrobacter sp.
Names obtained from α-proteobacteria such as PC6, actinomycetes such as Gordonia sp. KANMONKAZ-1129, labyrinthulas such as Schizophytriuym sp. Can do. Natural extracts and chemically synthesized products are commercially available and are readily available.

  Astaxanthin is 3,3′-dihydroxy-β, β-carotene-4,4′-dione and has stereoisomers. Specifically, three stereoisomers of (3R, 3′R) -astaxanthin, (3R, 3 ′S) -astaxanthin and (3S, 3 ′S) -astaxanthin are known. Any of these can be used. The present invention includes monoesters and diesters of these astaxanthin isomers.

  In the present invention, the fatty acid ester of astaxanthin may be any of those derived from natural products or those obtained by synthesis, but those derived from natural products in which astaxanthin esters are dissolved in various oils and fats are preferred from absorption in the body. Natural sources include, for example, a krill extract, a faffia yeast extract, and a hematococcus alga extract. Particularly preferred is a hematococcus alga extract depending on the stability of astaxanthin and the type of ester of astaxanthin.

  Fatty acid esters of astaxanthin have not been observed to be mutagenic, are known to be highly safe compounds, and are widely used as food additives (Jiro Takahashi et al .: Toxicity test of hematococcus alga astaxanthin-Ames Test, rat single dose toxicity test, rat 90 day repeated oral dose toxicity test-, clinical medicine, 20: 867-881, 2004).

  Haematococcus algae is a green algae belonging to the Volboxic Chlamydomonas family, and since it is a green algae, it has a high chlorophyll content and is green, and it swims in the water with two flagella, but it lacks nutrient sources, changes in temperature, etc. Under starvation conditions, dormant spores are formed, the astaxanthin content is increased, and red spheres are formed. In the present invention, hematococcus in any state can be used, but it is preferable to use hematococcus that has become dormant spores containing a large amount of astaxanthin. In addition, among green algae belonging to the genus Haematococcus, for example, Haematococcus pluvialis is preferable.

  As a method for culturing Haematococcus green algae, a hermetically sealed culture method is preferred in which no foreign microorganisms are mixed and propagated and other contaminants are not mixed. For example, a partially open-type dome shape, conical shape or cylindrical shape is preferable. A culture method using a culture medium having a culture apparatus and a gas discharge device movable within the apparatus (International Publication No. 99/50384), or culturing by irradiating light from inside a sealed culture apparatus And a method using a flat culture tank or a tube-type culture layer are suitable.

  The method for obtaining an extract from Haematococcus algae according to the present invention includes a method in which Haematococcus algae is dried and pulverized and then extracted with an organic solvent such as acetone or alcohol, and the Haematococcus algae is suspended in an organic solvent and pulverized and extracted simultaneously. Or a supercritical extraction method using carbon dioxide or the like.

The supercritical extraction method can be performed by a conventional method. For example, Hirose (Ind Eng Chem Res, 2006, 45 (10), 3652-3657, Extraction
of Astaxanthin from Haematococcus pluvialis Using Supercritical CO2 and Ethanol
as Entrainer) et al.

  Various methods are known for extracting and purifying the culture or the crustacean using an organic solvent. For example, since astaxanthin and its esters are oil-soluble substances, astaxanthin-containing components can be extracted from natural products containing astaxanthin with an oil-soluble organic solvent such as acetone, alcohol, ethyl acetate, benzene, and chloroform. Also, supercritical extraction can be performed using carbon dioxide, water, or the like. After extraction, the solvent is removed according to a conventional method to obtain a mixed concentrate of monoester type astaxanthin and diester type astaxanthin. The obtained concentrate can be further purified by separation column or lipase decomposition, if desired.

  A method of drying Haematococcus algae cultured in the above-mentioned dome type culture apparatus or closed type culture apparatus, extracting with acetone after pulverization, or performing pulverization and extraction in acetone at the same time, and then removing acetone to extract astaxanthin (Japanese Patent Laid-Open No. 2006-70114) has almost no oxidation of astaxanthin because it does not come into contact with air, and there are few impurities, that is, there are few substances that inhibit the effect of the present invention, and it contains astaxanthin and triglycerides in high purity. This is preferable.

In the present invention, the component (B) to be combined with the component (A) astaxanthin is one or more selected from the following agents. In the following specific examples, “derivatives” include esters, salts, and glycosides.
Component (B) includes cysteine and derivatives thereof, glutathione and derivatives thereof, tranexamic acid and derivatives thereof, arbutin and derivatives thereof, hydroquinone and derivatives thereof, ascorbic acid and derivatives thereof (ascorbyl magnesium phosphate, ascorbyl aminopropyl phosphate, Sodium ascorbyl phosphate, ascorbic acid glucoside, ascorbic acid sulfate, ascorbyl dipalmitate, ascorbyl tetraisopalmitate, etc.), ellagic acid and its derivatives, resorcin and its derivatives, endothelin antagonists, grabrizine, glabrene, liquiritin, isoliquiritin and Licorice extract, placenta extract, illesen extract, sunflower extract, Ibukitorano extract, Agetsu extract, Ogon Nevana extract, onionis extract, seaweed extract (comb, macombu, wakame, hijiki, hibamata, sujime, trolokombu, kajime, tsuruarame, chigaiso, hondawala, giant kelp, etc .; , Sugiori, Usubanori, Asakusa Nori, Pinus, Tosakamatsu, Funori, Ogonori, Kamenori, Igisu, Egonori, and other red algae; Green algae such as Aomidoro; cyanobacteria such as spirulina), Clara extract, gokahi extract, saicin extract, hawthorn extract, white lily extract, peonies extract, sempukuka extract, Mulberry) extract, soy extract, tea extract, toki extract, beechlen extract, beech extract, grape seed extract, hop extract, squid extract, yukinoshita extract, pearl barley (yokuinin) extract, senkyu Extract, chamomile extract, raspberry extract, coffee extract, rice extract, wheat germ extract, lily extract, molasses extract, yeast extract, microbial fermentation metabolites (from lactic acid bacteria, bifidobacteria, etc.), citrus Acid, lactic acid, tartaric acid, malic acid, glycolic acid, succinic acid, vitamin E and its derivatives, vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin Adenine dinucleotide, cyanocobalamin, folic acid, nicotinamide, nicoti Nicotinic acids such as benzyl acid, cholines, etc.), vitamin A and derivatives thereof (retinol palmitate, retinol acetate such as retinol acetate, retinal such as dehydroretinal and derivatives thereof), amino acids and derivatives thereof (aspartic acid, Acetylglutamine, arginine, glycine, glutamic acid, histidine, serine, taurine, thiotaurine, theanine, hydroxyproline, pyrrolidonecarboxylic acid, urea, etc., carotenoids (β-carotene, lycopene, β-cryptoxanthin, lutein, zeaxanthin, capsanthin, Fucoxanthin, etc.), polyphenols (flavonoids, catechins, etc.), superoxide dismutase (SOD) s, mannitol, 2-hydroxy-4-methoxybenzophenone, 2 Hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, 2-methoxyhexyl paramethoxycinnamate, 4-tert-butyl-4'-methoxydibenzoylmethane, titanium oxide, zinc oxide, olive oil, persic oil, sunflower oil And jojoba oil.
More preferred are cysteine and its derivatives, glutathione and its derivatives, tranexamic acid and its derivatives, arbutin and its derivatives, hydroquinone and its derivatives, ascorbic acid and its derivatives, ellagic acid and its derivatives, resorcin and its derivatives, endothelin Antagonist, licorice extract, placenta extract, citric acid, lactic acid, tartaric acid, malic acid, glycolic acid, succinic acid, vitamin E and its derivatives, vitamin B and its derivatives, vitamin A and its derivatives, amino acids and their derivatives, Examples include carotenoids, polyphenols, and superoxide dismutase (SOD).

  In the component (B), cysteine and derivatives thereof, glutathione and derivatives thereof, tranexamic acid and derivatives thereof, ascorbic acid and derivatives thereof, ellagic acid and derivatives thereof, resorcin and derivatives thereof, endothelin antagonists, grabrizine, glabrene, liquiritin, Isoliquiritin and licorice extract, placenta extract, illesen extract, sunflower extract, Ibukitorano extract, Agetsu extract, Ogon (Koganebana) extract, Onionis extract, seaweed extract, Clara (Kujin) Extract, Sesame extract, Saicin extract, Hawthorn extract, Shirayuri extract, Peonies extract, Sempukuka extract, Sakuhakuhi (mulberry) extract, Soybean extract, Tea extract, Toki extract, Byakuren extract, Beech extract, grape seed extraction , Hop extract, micaika extract, yukinoshita extract, pearl barley (yokuinin) extract, nematode extract, chamomile extract, raspberry extract, coffee extract, rice extract, wheat germ extract, lily extract, molasses Extract, yeast extract, microbial fermentation metabolite, citric acid, lactic acid, tartaric acid, malic acid, succinic acid, vitamin E and its derivatives, vitamin B and its derivatives, vitamin A and its derivatives, amino acids and their derivatives, carotenoids , Polyphenols, superoxide dismutase (SOD), mannitol, olive oil, persic oil, sunflower oil, jojoba oil, etc. can be used in foods and drinks, more preferably cysteine and its derivatives, glutathione and its derivatives, tranexamic acid And its derivatives, arbutin and its Conductor, hydroquinone and its derivatives, ascorbic acid and its derivatives, ellagic acid and its derivatives, resorcin and its derivatives, endothelin antagonist, licorice extract, placenta extract, citric acid, lactic acid, tartaric acid, malic acid, glycolic acid, succinic acid Examples include acids, vitamin E and derivatives thereof, vitamin B and derivatives thereof, vitamin A and derivatives thereof, amino acids and derivatives thereof, carotenoids, polyphenols, and superoxide dismutase (SOD) s.

  The compounding amount of astaxanthin in the whitening composition of the present invention is 0.01-100 mg, preferably 0.1-30 mg for internal use, and 0.001-10 mg, preferably 0.01- 1 mg. The dosage varies depending on the age, weight, symptom level, and dosage form of the patient to be administered.

  The blending ratio of astaxanthin and component (B) in the whitening composition of the present invention differs depending on whether component (B) is hydrophilic or lipophilic because ataxanthin is lipophilic, but generally 1: 0. It can mix | blend in the ratio of 01-1000, Preferably it is 1: 0.1-100. The whitening composition of the present invention can be blended in the range of 0.001 to 99.9% by weight, preferably 0.01 to 90% by weight, based on the total amount to be blended.

  When using the whitening composition of this invention, it can be used with the form of normal food-drinks, a skin external preparation, or a pharmaceutical.

  The pharmaceutical comprising the whitening composition of the present invention can be administered orally or parenterally. Examples of oral dosage forms include solid dosage forms such as tablets, intraoral quick disintegrating tablets, capsules, granules and fine granules, and liquid dosage forms such as syrups and suspensions. Parenteral dosage forms are administered in the form of injections, eye drops, nasal drops, patches, ointments and suppositories. A lipid-dispersed preparation is effective for increasing blood concentration. Pharmaceutical products include quasi-drugs.

  The medicine containing the whitening composition of the present invention may contain an appropriate amount of various additives used for production of general preparations. Examples of such additives include excipients, binders, acidulants, foaming agents, artificial sweeteners, fragrances, lubricants, colorants, stabilizers, pH adjusters, and surfactants. Examples of excipients include corn starch, potato starch, wheat starch, rice starch, partially pregelatinized starch, pregelatinized starch, and starches such as porous starch, sugars such as lactose, sucrose, and glucose, mannitol, xylitol, Examples thereof include sugar alcohols such as erythritol, sorbitol, maltitol, magnesium aluminate metasilicate, hydrotalcite, anhydrous calcium phosphate, precipitated calcium carbonate, calcium silicate, and light anhydrous silicic acid. Examples of the binder include hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, gum arabic powder, gelatin, and pullulan. Examples of the disintegrant include starch, agar, carmellose calcium, sodium carboxymethyl starch, croscarmellose sodium, crospovidone, crystalline cellulose, and F-MELT (trademark, manufactured by Fuji Chemical Industry Co., Ltd.). Examples of sour agents include citric acid, tartaric acid, malic acid, ascorbic acid and the like. Examples of the foaming agent include sodium bicarbonate and sodium carbonate. Examples of the sweetener include saccharin sodium, dipotassium glycyrrhizin, aspartame, stevia and thaumatin. Examples of the fragrances include lemon oil, orange oil, menthol and the like. Examples of the lubricant include magnesium stearate, sucrose fatty acid ester, polyethylene glycol, talc, stearic acid, and sodium stearyl fumarate. Examples of the colorant include edible pigments such as edible yellow No. 5, edible red No. 2, and edible blue No. 2, edible lake pigments, and iron sesquioxide. Examples of the stabilizer include sodium edetate, tocopherol, cyclodextrin and the like. Examples of the pH adjuster include citrate, phosphate, carbonate, tartrate, fumarate, acetate, amino acid salt and the like. Examples of the surfactant include polysorbate 80, methyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, polyoxyethylene sorbitan monolaurate, gum arabic, and powdered tragacanth. In order to improve the absorption and formulation of astaxanthin and tocotrienol, it can be in a powder state.

  For syrups, drinks, suspensions, eye drops, injections and other liquids, active ingredients are adjusted to pH, buffers, solubilizers, suspensions, etc., as required, tonicity agents, stabilizers, antiseptics It can be formulated by a conventional method in the presence of an agent. Examples of the suspending agent include polysorbate 80, methyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, polyoxyethylene sorbitan monolaurate, gum arabic, and powdered tragacanth. Examples of the solubilizer include polysorbate 80, hydrogenated polyoxyethylene castor oil, nicotinamide, polyoxyethylene sorbitan monolaurate, macrogol, and castor oil fatty acid ethyl ester. Examples of the stabilizer include sodium sulfite and sodium metasulfite. Examples of the preservative include methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, sorbic acid, phenol, cresol, chlorocresol and the like.

  There are no particular limitations on the form of the external preparation for skin, for example, cosmetics such as emulsions, creams, lotions, packs, dispersions, cleaning agents, makeup cosmetics, scalp / hair products, ointments, creams, and external use. It can be a pharmaceutical such as a liquid. In addition to the above components, components commonly used in skin external preparations such as cosmetics and pharmaceuticals, such as whitening agents, moisturizers, various skin nutritional components, ultraviolet absorbers, antioxidants, oily components, surfactants, thickeners , Alcohols, coloring agents, water, preservatives, fragrances and the like can be appropriately blended as necessary.

  The composition of this invention can be mix | blended and used for food-drinks, and can acquire the same effect.

  As foods and drinks, supplements, functional health foods, and special-purpose foods are preferred because they can be used as supplements, functional health foods, special-purpose foods, and general foods. It can be ingested in the same form, solid dosage forms such as tablets, buccal disintegrating tablets, capsules, granules, fine granules, and liquid dosage forms such as syrups and suspensions. Among ingredients used in the above pharmaceutical preparations, those that can be used in foods can be selected, in addition to milk protein, soy protein, egg albumin protein, etc., or egg white oligopeptide, soy hydrolyzate that is a degradation product thereof, A mixture of amino acids alone can also be used in combination. In addition, when provided in the form of a drink, nutritional additives such as amino acids, vitamins and minerals, sweeteners, spices, fragrances, and pigments may be added to improve the nutritional balance and flavor during intake. Good. The form of the food or drink of the present invention is not limited to these.

  Examples of forms of general foods, that is, foods and drinks include margarine, butter, butter sauce, cheese, fresh cream, shortening, lard, ice cream, yogurt, dairy products, sauce meat products, fish products, pickles, french fries, potato chips , Snacks, kakimochi, popcorn, sprinkles, chewing gum, chocolate, pudding, jelly, gummy candy, candy, drop, caramel, bread, castella, cake, donuts, biscuits, cookies, crackers, macaroni, pasta, ramen, buckwheat, udon , Salad oil, instant soup, dressing, eggs, mayonnaise, miso, etc., or carbonated or non-carbonated beverages such as fruit juices, soft drinks, sports beverages, non-alcohol or liquor such as tea, coffee, cocoa Yuru, it can be added to examples of the general foods such as alcoholic beverages, such as medicinal liquor.

  In foods and drinks, the cosmetic composition of the present invention is blended with raw materials for general foods and processed and manufactured according to a conventional method. The blending amount varies depending on the form of the food and is not particularly limited. Generally, the cosmetic composition of the present invention can be appropriately selected by those skilled in the art according to the type of food and drink, and the above-mentioned amount is blended. Can do.

  In order to describe the present invention in more detail, examples will be given below, but it goes without saying that the present invention is not limited to these examples.

[Experiment 1] Difference in melanin synthesis inhibitory action depending on application timing As an evaluation system, a three-dimensional skin model “LabCyte” is a human skin epithelial cell marketed by Japan Tissue Engineering Co., Ltd. (J-TEC).
"MELANO-MODEL" was used. The culture was started according to the description of the kit, and the culture medium and the test substance were replaced with new ones every two days. Culture was performed for 14 days under the application timing shown in Table 1 and the test substance conditions shown in Table 2. As a comparative example, tranexamic acid that is already known to have an inhibitory action on melanin synthesis was used. After 14 days, the absorbance at 405 nm, which is an index of the amount of melanin, was measured for the lysate obtained by extracting melanin from each treated tissue, and the melanin suppression index was calculated by the following equations [1] and [2]. At the same time, the cell viability was determined colorimetrically at a measurement wavelength of 570 nm and a control wavelength of 650 nm using MTT Assay, and calculated by the following equation [3]. The results are shown in Table 3.
formula:
Melanin inhibition rate of each test substance = (1−405 nm absorbance of tissue lysate during treatment of each test substance / 405 nm absorbance of control tissue lysate) × 100 [1]
Melanin inhibition index = melanin inhibition rate of each test substance / melanin inhibition rate of astaxanthin [2]
Cell viability = (570 nm absorbance at each test substance treatment−650 nm absorbance at each test substance treatment) / (control 570 nm absorbance−control 650 nm absorbance) [3]

[Table 1] Application timing

[Table 2] Test substance conditions

[Table 3] Results

  As is apparent from the results in Table 3, the inhibitory action of tranexamic acid on melanin production was greatly reduced by changing the timing of application. In contrast, astaxanthin was further increased by changing the timing of application. In all cases, it was confirmed that the cell viability was very high and toxicity was low. Therefore, by applying a combination of astaxanthin and existing whitening ingredients to the skin, it exerts an extremely excellent melanin production inhibitory effect, effectively suppressing skin blackening, spots, freckles, etc. due to sunburn, and whitening In addition, skin effect can be expected.

[Experiment 2] Melanin synthesis inhibition combined effect In the method of Experiment 1, L-cysteine, which is already known to have a melanin synthesis inhibitory effect as a comparative example, and Table 1 application timing 1 conditions in combination with it are shown. The melanin synthesis inhibition index was calculated. At the same time, the cell viability was calculated according to the same method. The results are shown in Table 4.

[Table 4] Results

  As is apparent from the results in Table 4, when used in combination, an extremely excellent whitening effect was obtained as compared with the time of each individual treatment. In addition, a very high cell viability was observed both alone and in combination, and it was confirmed that the toxicity was low. Therefore, by applying a combination of astaxanthin and an existing whitening agent to the skin, it exhibits an extremely excellent melanin production inhibitory effect, effectively suppressing skin blackening, spots, freckles, etc. due to sunburn, and whitening And it turns out that the skin-beautifying effect is obtained.

Claims (7)

Next components (A) and (B)
(A) Astaxanthin,
(B) cysteine and derivatives thereof, glutathione and derivatives thereof, tranexamic acid and derivatives thereof, arbutin and derivatives thereof, hydroquinone and derivatives thereof, ascorbic acid and derivatives thereof, ellagic acid and derivatives thereof, resorcin and derivatives thereof, endothelin antagonists, Gravulidine, glabrene, liquiritin, isoliquiritin and licorice extract, placenta extract, illesen extract, sunflower extract, Ibukitorano extract, Agetsu extract, Ogon (Koganebana) extract, Ononis extract, seaweed extract , Clara (Kujin) extract, Gokahi extract, Saishin extract, Hawthorn extract, Shirayuri extract, Peonies extract, Sempakuka extract, Sakuhaku (mulberry) extract, Soy extract, Tea extract, Toki extract Thing, beer Len extract, beech extract, grape seed extract, hop extract, squid extract, saxifrage extract, pearl barley (yokuinin) extract, nematode extract, chamomile extract, raspberry extract, coffee extract, rice extract , Wheat germ extract, lily extract, molasses extract, yeast extract, microbial fermentation metabolites, citric acid, lactic acid, tartaric acid, malic acid, glycolic acid, succinic acid, vitamin E and its derivatives, vitamin B and its Derivatives, vitamin A and derivatives thereof, amino acids and derivatives thereof, carotenoids, polyphenols, superoxide dismutase (SOD) s, mannitol, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfone Acid sodium, paramethoxycinnamic acid-2- Hexyl, 4-tert-butyl-4'-methoxydibenzoylmethane, titanium oxide, zinc oxide, olive oil, persic oil, sunflower oil, one or more selected from jojoba oil,
A whitening composition containing Component (B) is cysteine and its derivatives, glutathione and its derivatives, tranexamic acid and its derivatives, ascorbic acid and its derivatives, ellagic acid and its derivatives, resorcin and its derivatives, endothelin antagonist, grabrizine, glabrene, liquiritin, isoliquiritin And licorice extract, placenta extract, illessen extract, sunflower extract, Ibukitranano extract, Agetsu extract, Ogon (Koganebana) extract, Ononis extract, seaweed extract, Clara extract , Gokahi extract, Saishin extract, Hawthorn extract, Shirayuri extract, Peonies extract, Sempukuka extract, Sakuhakuhi (mulberry) extract, Soy extract, Tea extract, Toki extract, Beechlen extract, Beech tree Extract, grape seed extract, Cup extract, mica squid extract, saxifrage extract, pearl barley (yokuinin) extract, nematode extract, chamomile extract, raspberry extract, coffee extract, rice extract, wheat germ extract, lily extract, molasses Extract, yeast extract, microbial fermentation metabolite, citric acid, lactic acid, tartaric acid, malic acid, succinic acid, vitamin E and its derivatives, vitamin B and its derivatives, vitamin A and its derivatives, amino acids and their derivatives, carotenoids 2. A whitening composition according to claim 1, which is one or more selected from polyphenols, superoxide dismutase (SOD), mannitol, olive oil, persic oil, sunflower oil, jojoba oil, and the like. A pharmaceutical comprising the whitening composition according to claim 1. An external preparation for skin comprising the whitening composition according to claim 1. A food or drink comprising the whitening composition according to claim 2. A skin external preparation comprising the astaxanthin or the whitening composition according to claim 1, and cysteine and derivatives thereof, glutathione and derivatives thereof, tranexamic acid and derivatives thereof, ascorbic acid and derivatives thereof, ellagic acid and derivatives thereof, Resorcins and derivatives thereof, endothelin antagonists, grabrizine, glabrene, liquiritin, isoliquiritin and licorice extract, placenta extract, illesen extract, sunflower extract, Ibukitora noo extract, Agetsu extract, Ogon (Koganebana) Extract, Ononis extract, seaweed extract, Clara extract, gokahi extract, Saishin extract, Hawthorn extract, Shirayuri extract, Peonies extract, Sempukuka extract, Sakuhakuhi (mulberry) extract, soybean Extract, tea extract, Yuki extract, beechlen extract, beech extract, grape seed extract, hop extract, mica extract, cypress extract, pearl barley (yokuinin) extract, nematode extract, chamomile extract, raspberry extract, coffee extract Product, rice extract, wheat germ extract, lily extract, molasses extract, yeast extract, microbial fermentation metabolite, citric acid, lactic acid, tartaric acid, malic acid, succinic acid, vitamin E and its derivatives, vitamin B and One or more selected from derivatives thereof, vitamin A and derivatives thereof, amino acids and derivatives thereof, carotenoids, polyphenols, superoxide dismutase (SOD), mannitol, olive oil, persic oil, sunflower oil, jojoba oil, etc. Skin whitening method using both foods and drinks containing Food and drink comprising the astaxanthin or the whitening composition according to claim 2, cysteine and derivatives thereof, glutathione and derivatives thereof, tranexamic acid and derivatives thereof, arbutin and derivatives thereof, hydroquinone and derivatives thereof, ascorbic acid and Derivatives thereof, ellagic acid and derivatives thereof, resorcin and derivatives thereof, endothelin antagonists, grabrizine, glabrene, liquiritin, isoliquiritin and licorice extract, placenta extract, irasen extract, sunflower extract, ibukitorano extract , Agetsu extract, Ogon (Koganebana) extract, Ononis extract, seaweed extract, Clara (kujin) extract, gokahi extract, Saishin extract, Hawthorn extract, Shirayuri extract, Peonies extract, Sempukuka extract , Sohakuhaku (mulberry) extract, soybean extract, tea extract, Japanese persimmon extract, beechlen extract, beech extract, grape seed extract, hop extract, squid extract, yukinoshita extract, pearl barley (yokuinin) extract , Citrus extract, chamomile extract, raspberry extract, coffee extract, rice extract, wheat germ extract, lily extract, molasses extract, yeast extract, microbial fermentation metabolites, citric acid, lactic acid, tartaric acid , Malic acid, glycolic acid, succinic acid, vitamin E and derivatives thereof, vitamin B and derivatives thereof, vitamin A and derivatives thereof, amino acids and derivatives thereof, carotenoids, polyphenols, superoxide dismutase (SOD) s, mannitol, 2 -Hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy From sodium benzophenone-5-sulfonate, 2-ethylhexyl paramethoxycinnamate, 4-tert-butyl-4'-methoxydibenzoylmethane, titanium oxide, zinc oxide, olive oil, persic oil, sunflower oil, jojoba oil, etc. A method for whitening the skin, using both of the external preparations for skin containing one or more selected.