JP2010273894A - Cover sheet used for coating transdermal patches - Google Patents

Abstract

A cover sheet for coating a transdermal absorbable patch preparation that can be easily applied to a desired position, has excellent fixability to the skin surface of a transdermal absorbable patch preparation, and is inconspicuous in the applied state. To provide.
A cover sheet used for coating a transdermally absorbable patch preparation, the cover sheet comprising a carrier, a support, an adhesive layer and a release liner in this order, the carrier on one surface, By having a positioning print pattern corresponding to a predetermined portion of the transdermal absorbable patch preparation, the transdermal absorbable patch preparation can be easily and accurately coated so as to be at a predetermined position on the cover sheet. A cover sheet capable of sufficiently fixing the skin-absorbing patch preparation to the skin surface is obtained.
[Selection] Figure 1

Description

  The present invention relates to a cover sheet used for coating a transdermally absorbable patch preparation. More specifically, the present invention relates to a cover sheet that can more easily and reliably fix a transdermally absorbable patch preparation to the skin surface and is inconspicuous in the applied state.

  In recent years, a percutaneous administration method in which a drug is administered into the body through the skin surface has attracted attention, and as one of them, a patch preparation for transdermal administration using a drug-containing adhesive tape or sheet has been developed. In such a patch preparation, the preparation is fixed to the skin surface by the adhesive force of the adhesive, the drug in the preparation is released to the skin surface, and the drug is percutaneously absorbed inside the skin. In order to sufficiently percutaneously absorb the drug inside the skin, it is required to ensure fixation to the skin surface, and for this purpose, it is necessary to increase the adhesive strength of the adhesive. However, when the adhesive strength of the adhesive is increased, the fixation to the skin surface increases, but on the other hand, there is a pain when peeling from the skin surface, and skin irritation or skin damage due to exfoliation may occur. Therefore, the adjustment of adhesive strength is a very important requirement in relation to skin irritation.

  In addition, depending on the type of drug used in the transdermally absorbable patch preparation, there are those that are difficult to absorb percutaneously simply by being included in the adhesive. In such a case, a transdermal absorption enhancer is also present. There is a need. Usually, many percutaneous absorption enhancers are liquid at room temperature, and when these are contained, the adhesive strength tends to decrease. As a result, during the application of the transdermal absorbable patch preparation to the skin surface, the adhesive layer may float from the skin surface, resulting in decreased adhesion, peeling or falling off. The improvement effect may not be obtained.

  As a method for solving such a problem, there is a method of covering the transdermally absorbable patch preparation from above with a thin adhesive sheet, so-called cover sheet. In such a method using a cover sheet, the physical properties (for example, stretchability), adhesive properties, and the application position of the cover sheet greatly affect the fixability and skin irritation of the transdermally absorbable patch preparation. Patent Document 1 discloses a cover sheet in which adhesiveness and stretchability of the cover sheet are adjusted as a cover sheet for covering a patch preparation. The cover sheet cannot sufficiently secure a close contact portion between the skin surface and the cover sheet, and the transdermal absorbable patch preparation may not be sufficiently fixed to the skin surface. In addition, it is difficult to apply the transdermally absorbable patch preparation in the center of the cover sheet, and improvement in operability is demanded by medical staff.

  Patent Document 2 discloses a medical adhesive sheet having a printing part whose shape does not deform before and after application. The medical patch sheet is printed with a frame for clearly observing, observing and observing characters and affected areas for infants. The printing section is provided so as to remain on the surface of the film base material after the backing sheet is peeled off, and is intended to make the printing section visible in an attached state. However, a subject (for example, a patient) to which a transdermal absorbable patch preparation or a cover sheet thereof is usually applied is suitable for a patch preparation that is familiar with the color of the skin and is not noticeable after being applied. Therefore, the medical patch sheet described in Patent Document 2 can be suitably used only for specific purposes such as when it is necessary to quantitatively grasp the wound treatment status, and such a patch sheet is almost always used. Not desired.

JP 11-343232 A No. 7-25935

  The present invention has been made in order to solve the above-described conventional problems. The object of the present invention is to fix the transdermal absorbable patch preparation on the skin surface easily and easily at a desired position. It is another object of the present invention to provide a cover sheet for coating a transdermally absorbable patch preparation which is excellent in the state of being applied and is inconspicuous in the applied state.

The cover sheet of the present invention is used for coating a transdermally absorbable patch preparation. The cover sheet includes a carrier, a support, an adhesive layer, and a release liner in this order, and the carrier has a positioning print pattern corresponding to a predetermined portion of the transdermally absorbable patch preparation on one surface. .
In a preferred embodiment, the carrier, support, and pressure-sensitive adhesive layer are transparent.
In preferable embodiment, the distance of the peripheral part of the said support body and the outermost part of the said positioning printing pattern is 10 mm-30 mm.
In a preferred embodiment, the positioning printing pattern has the same shape as the outline of the transdermally absorbable patch preparation.
In a preferred embodiment, the positioning printing pattern has two or more portions that coincide with the contour of the transdermally absorbable patch preparation.
In a preferred embodiment, the portion of the positioning printing pattern that coincides with the contour of the transdermal absorbable patch preparation is point-symmetric with respect to the center of the transdermal absorbable patch preparation and / or the transdermal absorbable patch preparation. It is formed so as to be line symmetric with respect to the symmetry axis.
In a preferred embodiment, the cover sheet of the present invention has two sets of positioning print patterns formed so as to be point-symmetric and / or line-symmetric.

  In the cover sheet of the present invention, the carrier laminated on the support has a positioning print pattern corresponding to a predetermined portion of the transdermally absorbable patch preparation on one side, so that it can be easily and accurately passed. The skin-absorbable patch preparation can be coated so as to be in a desired position of the cover sheet (for example, the center of the cover sheet). Therefore, the cover sheet of the present invention can sufficiently fix the transdermally absorbable patch preparation to the skin surface. Furthermore, since the carrier is removed after the cover sheet is pasted, the positioning printing pattern does not remain on the support after the cover is pasted. Therefore, the transdermally absorbable patch preparation and the cover sheet can be made inconspicuous even after the sticking.

It is a schematic sectional drawing of the cover sheet in preferable embodiment of this invention. It is a schematic perspective view of the specific example of the cover sheet in preferable embodiment of this invention. It is a schematic perspective view of the specific example of the cover sheet in another preferable embodiment of this invention. It is a schematic perspective view of the specific example of the cover sheet in another preferable embodiment of this invention. It is a schematic perspective view of the specific example of the cover sheet in another preferable embodiment of this invention. It is a schematic perspective view of the specific example of the cover sheet in another preferable embodiment of this invention. It is a schematic perspective view of the specific example of the cover sheet in another preferable embodiment of this invention. It is a schematic perspective view of the specific example of the cover sheet in another preferable embodiment of this invention. It is a schematic perspective view of the specific example of the cover sheet in another preferable embodiment of this invention. It is the schematic which shows the measurement location of the shift | offset | difference of the sticking location in an Example.

<A. Overview of cover sheet>
The cover sheet of the present invention is used for coating a transdermally absorbable patch preparation. FIG. 1 is a schematic cross-sectional view of a cover sheet according to a preferred embodiment of the present invention. The cover sheet 100 includes a carrier 10, a support 20, a pressure-sensitive adhesive layer 30, and a release liner 40 in this order. The carrier 10 has a positioning print pattern 50 on the surface opposite to the surface in contact with the support 20. The positioning print pattern 50 corresponds to a predetermined portion of the transdermally absorbable patch preparation to be coated. In another embodiment (not shown), the carrier 10 has a positioning print pattern 50 on the surface in contact with the support 20.

  There is no restriction | limiting in particular as a structure of a cover sheet, Arbitrary appropriate structures may be employ | adopted. Specifically, configurations described in Japanese Patent No. 3152966, Japanese Patent Laid-Open No. 2005-218494, Japanese Patent Laid-Open No. 2005-218495, and the like are given, and the configurations described in these patent documents are preferable. The descriptions of these patent documents are incorporated herein by reference. Each member constituting the cover sheet of the present invention preferably has transparency, and it is particularly preferable that the carrier, the support, and the pressure-sensitive adhesive layer all have transparency. With such a configuration, the cover sheet of the present invention can be easily attached at a desired position.

  The shape of the cover sheet of the present invention can be any suitable shape depending on the purpose and the shape of the transdermally absorbable patch preparation, and specifically includes a square, a rectangle, a circle, an ellipse, and the like. It is done. The shape of the cover sheet is preferably the same outer shape as that of the transdermally absorbable patch preparation, more preferably a shape obtained by enlarging the transdermally absorbable patch preparation at a certain magnification (ie, similar to the transdermal absorbable patch preparation). is there. In addition, when the shape of a cover sheet has a corner | angular part like a square or a rectangle, it is preferable to round a corner | angular part (what is called a round). By rounding the corners, it is possible to prevent end peeling of the cover sheet.

  The total thickness of the cover sheet of the present invention can be set to any appropriate value. For example, the thickness of the support and the pressure-sensitive adhesive layer may be in a range described later.

  The size (plane area) of the cover sheet of the present invention may be larger than that of the transdermally absorbable patch preparation, and can be set to any appropriate size according to the size of the transdermally absorbable patch preparation. Preferably, the size of the cover sheet is such that the periphery of the support 20 and the outline of the transdermally absorbable patch preparation are in the following ranges. Specifically, the distance between the peripheral edge of the support and the contour of the transdermally absorbable patch preparation is preferably 10 mm to 30 mm, more preferably 10 mm to 20 mm. By setting the distance between the peripheral edge of the support and the contour of the transdermally absorbable patch preparation within the above range, it is possible to prevent the inflow of air from the outside after sticking. The sheet can be sufficiently fixed to the skin surface. Furthermore, the exfoliation phenomenon due to the pressure-sensitive adhesive layer of the cover sheet can be prevented at the time of peeling, and the balance between the fixation to the skin surface and the skin irritation can be achieved.

  Further, the length of the cover sheet (quantitatively, the length of the support) is preferably 110 to 400%, more preferably 110 to 300% with respect to the length of the transdermally absorbable patch preparation. is there. By setting the ratio of the length of the support to the transdermally absorbable patch preparation within such a range, excellent fixability can be realized with the minimum necessary size (that is, low cost). In the present specification, the “length” refers to a characteristic length of the shape, for example, the diameter in the case of a circle, the major axis or minor axis in the case of an ellipse, and the square or rectangle in the case of a square or rectangle. The length of one side or one diagonal line.

<A-1. Career>
The carrier 10 has easy releasability with respect to the support, gives rigidity and shape retention to the cover sheet body, and improves handling. By using the carrier, the cover sheet can be prevented from floating during the attaching operation. In addition, the adhesive force with respect to the support body of a carrier needs to be made smaller than the skin adhesive force of an adhesive layer. Further, the carrier prevents the cover sheet from being damaged or damaged before use, and also functions as a protective layer that keeps the film surface in a sterile state for a long time when the cover sheet is sterilized. In the cover sheet 100 of the present invention, one surface of the carrier 10 (that is, the outermost layer surface of the cover sheet or between the carrier 10 and the support 20) corresponds to a predetermined portion of the transdermally absorbable patch preparation. A positioning print pattern 50 is formed.

  The carrier 10 can be made of any appropriate material depending on the purpose. Specific examples of such materials include plastic films (for example, polyethylene, polypropylene, polyester, or laminated composites thereof) and paper (for example, high-quality paper, kraft paper, etc.). The carrier is preferably made of a transparent plastic film such as polyethylene or polypropylene. By comprising a plastic film having transparency, it is easy to match the predetermined part of the transdermal absorption patch preparation to be coated with the positioning printing pattern, and the cover sheet can be easily pasted at a desired position, The efficiency of the pasting work is greatly improved.

  The thickness of the carrier 10 can vary depending on the application and the constituent materials. The thickness of the carrier is preferably 15 μm to 200 μm, more preferably 20 μm to 100 μm. Moreover, it is preferable that the carrier 10 has transparency. Since the carrier 10 is transparent, the predetermined part of the transdermally absorbable patch preparation to be coated can be easily aligned with the positioning printing pattern, and the cover sheet can be easily pasted at a desired position, and the pasting operation The efficiency is greatly improved.

  The carrier may have a dividing part that divides the carrier into two or more. When the carrier has a dividing portion, the carrier is more easily peeled off after the cover sheet is stuck, and the operability is further improved. As the configuration of the dividing portion, for example, the configuration described in JP 2008-264170 A can be cited. The description of the patent document is incorporated by reference in this specification.

<A-2. Support>
The support 20 supports and protects the pressure-sensitive adhesive layer in the pasted state. Any appropriate material can be used as the material constituting the support 20 as long as it can follow the movement of the deposition site. Specific examples include acrylic polymers, polyethylene polymers, ethylene-vinyl acetate copolymers, polyurethane polymers, polyether polyester polymers, and nylon derivatives. The material constituting the support is preferably an acrylic polymer, a polyurethane polymer, a polyether polyester polymer, and a nylon derivative. By using these materials, it is excellent in water vapor permeability when formed into a film, hardly hinders breathing of the covered skin, and can suppress the skin whitening phenomenon. The support 20 preferably has transparency. Since the support 20 has transparency, the predetermined part of the transdermally absorbable patch preparation to be coated can be easily aligned with the positioning printing pattern, and the cover sheet can be easily pasted at a desired position. The efficiency of work is greatly improved. Moreover, it can be set as the cover sheet which is not conspicuous even after affixing.

  Arbitrary appropriate thickness may be employ | adopted for the thickness of the support body 20 according to a constituent material. The thickness of the support is preferably a thickness that can follow the movement of the deposition site, and is usually 20 to 150 μm, more preferably 25 to 75 μm.

<A-3. Adhesive layer>
Any appropriate pressure-sensitive adhesive can be adopted as the pressure-sensitive adhesive layer 30 as long as it is a pressure-sensitive adhesive used for medical purposes. Specific examples of such pressure-sensitive adhesives include natural rubber-based, synthetic rubber-based, acrylic-based, and silicone-based pressure-sensitive adhesives. Among these pressure-sensitive adhesives, acrylic pressure-sensitive adhesives are preferable. This is because it has transparency, can further suppress irritation to the skin, and is easy to adjust the physical properties of the adhesive. The pressure-sensitive adhesive layer 30 preferably has transparency. Since the adhesive layer 30 has transparency, it is easy to match the predetermined portion of the transdermally absorbable patch preparation to be coated with the positioning printing pattern, and the cover sheet can be easily attached to a desired position. The efficiency of the pasting work is greatly improved. Moreover, it can be set as the cover sheet which is not conspicuous even after affixing.

  Arbitrary appropriate thickness can be employ | adopted for the thickness of the adhesive layer 30 according to the objective and a use. The thickness of the pressure-sensitive adhesive layer is preferably 10 μm to 60 μm, and more preferably 20 μm to 50 μm. If it is such thickness, since it is excellent in the adhesiveness to the biological body surface, a transdermally absorbable patch preparation can fully be fixed to the skin surface.

<A-4. Release liner>
As the release liner 40, any appropriate release liner can be adopted as long as it can be satisfactorily peeled from the pressure-sensitive adhesive layer 30. Typically, the release liner has a substrate and a release treatment layer formed on the surface of the substrate. Specific examples of the substrate include plastic films (for example, polyethylene, polypropylene, polyester, or laminated composites thereof) and paper (for example, fine paper, kraft paper, etc.). The release treatment layer can be formed by subjecting the substrate surface to a silicone resin treatment, a fluorine resin treatment, or the like.

  The thickness of the release liner 40 can be appropriately set according to the purpose. The thickness of the release liner is preferably 50 μm to 250 μm, more preferably 75 μm to 200 μm. The release liner 40 may have a dividing portion as disclosed in Japanese Patent No. 3152966. The description of the patent document is incorporated by reference in this specification. The operability is improved when the release liner has a dividing portion.

<A-5. Positioning print pattern>
The positioning print pattern 50 is formed on one surface of the carrier 10. That is, in one embodiment, the positioning print pattern 50 is formed on the surface opposite to the surface in contact with the support 20 of the carrier 10 (the surface of the outermost layer of the cover sheet 100) as shown in the illustrated example. Alternatively, the positioning print pattern 50 may be formed on a surface (between the carrier 10 and the support 20) that contacts the support 20 of the carrier 10 (not shown). The positioning print pattern corresponds to a predetermined portion of the transdermally absorbable patch preparation to be coated. The predetermined part of the transdermally absorbable patch preparation may be a part corresponding to the inside or outline of the transdermally absorbable patch preparation, and may be any appropriate part.

  The positioning printing pattern preferably has the same shape as the contour of the transdermally absorbable patch preparation. By having such a positioning printing pattern, it is possible to apply the printing more accurately at a desired position. For example, in FIG. 2A, the positioning print pattern 50 and the transdermal absorbable patch preparation 200 are square, and in FIGS. 2B and 2C, the positioning print pattern 50 and the transdermal absorbable patch preparation 200 are circular. Moreover, as described above, the cover sheet of the present invention preferably has a shape obtained by enlarging the transdermally absorbable patch preparation at a constant magnification. For example, in FIG. 2A, the cover sheet 100 and the transdermally absorbable patch preparation 200 are square, and in FIG. 2B, the cover sheet 100 and the transdermally absorbable patch preparation 200 are circular. The shape of the cover sheet and the shape of the transdermally absorbable patch preparation may be different. For example, as in the embodiment shown in FIG. 2C, a positioning print pattern 50 corresponding to the contour of the circular transdermal absorbable patch preparation 200 may be formed on the square cover sheet 100.

  In another preferred embodiment, the positioning printing pattern has at least two portions that match the contour of the transdermally absorbable patch preparation. With such a positioning print pattern, it can be easily pasted at a desired position at a lower cost than forming a print pattern having the same shape as the contour. As a specific example of the positioning printing pattern having at least two portions that match the outline of the transdermal absorbable patch preparation, a pattern (FIG. 3A) that matches the four corners of the square transdermal absorbable patch preparation 200, Arc (FIG. 3B) corresponding to the circumference of transdermal absorbable patch preparation 200, straight line (FIG. 3C) at least partially matching each side of square transdermal absorbable patch preparation 200, square transdermal absorbability A pattern (FIG. 3D) corresponding to the diagonal of the patch preparation 200 is mentioned.

  More preferably, the positioning print pattern having at least two portions that coincide with the contour of the transdermal absorbable patch preparation is a point with respect to the center of the transdermal absorbable patch preparation, as shown in FIGS. 3A to 3D. It is formed so as to be symmetrical and / or line symmetric with respect to the axis of symmetry of the transdermally absorbable patch preparation. By forming such a positioning print pattern, it is possible to easily and accurately affix the cover sheet to a desired position while reducing the cost by reducing the positioning print pattern to be formed.

  The positioning print pattern 50 may not be formed only by a pattern corresponding to a predetermined portion of the transdermally absorbable patch preparation. For example, as in the embodiment shown in FIG. 4, a square-shaped positioning print pattern 50 is formed on the cover sheet 100 and pasted so that the transdermally absorbable patch preparation 200 is positioned at a desired portion of the grid. Good. Moreover, you may form the part corresponding to the center of a transdermally absorbable patch formulation, a diagonal, and an object axis | shaft as a positioning printing pattern.

  The positioning print pattern is not limited to the illustrated embodiment, and may be appropriately combined.

<B. Manufacturing method of cover sheet>
The cover sheet of the present invention can be manufactured by any appropriate method. For example, a method of laminating a carrier, a support, a pressure-sensitive adhesive layer, and a release liner in which the positioning printing pattern is formed in advance, or a laminate of a carrier, a support, a pressure-sensitive adhesive layer, and a release liner is prepared, and the laminate And a method of forming a positioning print pattern on the carrier.

  Any appropriate printing method can be used as a method for forming the positioning printing pattern on one surface of the carrier, for example, gravure printing method, flexographic printing method, offset printing method, relief printing method, screen printing method. Etc. The color of the positioning print pattern can be selected as appropriate, and is preferably not a color close to the skin color (for example, skin color) so that the position where the cover sheet is applied can be recognized well.

  In the laminate, the carrier and the support are temporarily attached in a peelable or easily peelable state. By setting it as such a state, a carrier can be peeled easily after sticking a cover sheet. Arbitrary appropriate methods can be used as a method of bonding the carrier and the support so as to be peeled off, and inflation molding, extrusion lamination molding, lamination molding, casting, and the like can be performed. Any appropriate method can be used as a method for temporarily attaching the carrier and the support in an easily peeled state. For example, a method in which a weak adhesive is interposed, a pressure method, a heat pressure bonding method, a natural rubber For example, a pressure bonding method using a binder such as

  As a method for forming the pressure-sensitive adhesive layer, any appropriate method can be used. Specifically, a method of applying a solution containing a composition forming the pressure-sensitive adhesive layer to a release liner, a pre-shaped pressure-sensitive adhesive Examples thereof include a method of providing a film made of the composition on a release liner.

<C. Attaching the cover sheet>
There is no restriction | limiting in particular as the sticking method of the cover sheet of this invention, What is necessary is just pasted so that the transdermally absorbable patch preparation which it is going to coat | cover may contact | adhere sufficiently and is fixed. Specifically, a method of attaching to a transdermal absorbable patch preparation fixed to the skin so that the positioning printing pattern of the cover sheet of the present invention and a predetermined part of the transdermal absorbable patch preparation match. It is done. In addition, after pasting on the cover sheet of the present invention in advance so that the positioning printing pattern of the cover sheet and a predetermined part of the transdermal absorbable patch preparation match, the transdermal absorbable patch preparation and the cover sheet are attached. It may be applied to the skin at the same time.

  The present invention will be further described using the following examples and comparative examples. The present invention is not limited only to these examples.

[Production Example 1]
Preparation of transdermally absorbable patch preparation (placebo) A laminate (thickness (basis weight): 160 mg / m ² ) obtained by laminating a polyethylene terephthalate film and a polyethylene terephthalate nonwoven fabric is used as a support, and acrylic is provided on the nonwoven fabric side of the support. The adhesive was applied and dried to form an adhesive layer (thickness: 200 μm). The obtained laminate of the support and the pressure-sensitive adhesive layer was cut out to 71 × 71 mm to obtain a transdermally absorbable patch preparation (placebo).

[Example 1]
An acrylic pressure-sensitive adhesive was coated on a support (polyurethane film, thickness: 30 μm) to form a pressure-sensitive adhesive layer having a thickness of 30 μm. Separately, one side of paper having a thickness of 100 μm was treated with a silicone resin to produce a release liner, and the obtained release liner was bonded to the pressure-sensitive adhesive layer on the side subjected to the silicone resin treatment. Next, a carrier (polypropylene film, thickness: 40 μm) was detachably bonded to the surface of the support on which the pressure-sensitive adhesive layer was not formed by extrusion lamination molding.
A straight cut line was added using a die cut roll so as to completely divide the carrier at the center of the carrier to form a carrier dividing portion. Subsequently, a hot melt adhesive was used to bond both sides of the carrier dividing portion so that the flap portion in which the corrugated dividing portion was formed by the die cut roll was covered with the carrier dividing portion.
The positioning printing pattern shown in FIG. 2A was formed by gravure printing (printing ink: gravure ink, color: blue) on the surface of the carrier not in contact with the support and the flap portion. A cover sheet 1 was obtained by cutting out 100 × 100 mm so that the positioning print pattern was located at the center of the cover sheet. The distance between the periphery of the support of the cover sheet 1 and the outermost part of the printed pattern was 14.5 mm.

[Example 2]
A cover sheet 2 was obtained in the same manner as in Example 1 except that the positioning print pattern shown in FIG. 3A was formed instead of the positioning print pattern shown in FIG. 2A. The distance between the periphery of the support of the cover sheet 2 and the outermost part of the printed pattern was 14.5 mm.

[Example 3]
A cover sheet 3 was obtained in the same manner as in Example 1 except that the positioning print pattern shown in FIG. 3C was formed instead of the positioning print pattern shown in FIG. 2A. The distance between the peripheral edge of the support of the cover sheet 3 and the outermost part of the printed pattern was 14.5 mm.

[Example 4]
A cover sheet 4 was obtained in the same manner as in Example 1 except that the positioning print pattern shown in FIG. 3D was formed instead of the positioning print pattern shown in FIG. 2A. The distance between the periphery of the support of the cover sheet 4 and the outermost part of the printed pattern was 14.5 mm.

[Comparative Example 1]
A cover sheet 5 was obtained in the same manner as in Example 1 except that the positioning print pattern was not formed.

<Evaluation>
The transdermal absorbable patch preparation (placebo) obtained in Production Example 1 is pasted on the back of the volunteer, and the cover sheets 1 to 5 are placed on the cover sheet 1-5 so that the transdermal absorbable patch preparation is located at the center of the cover sheet. And the deviation from the case where it was properly attached (attached to the center of the cover sheet) was measured. The displacement was measured at two locations on the cover sheet as shown in FIG. When pasted so that the transdermal absorbable patch preparation is located in the center of the cover sheet, the distance between the end of the cover sheet and the end of the transdermal absorbable patch is 14.5 mm. At the same time, the time required to attach the cover sheet was also measured. These sticking tests were carried out by 6 persons for the cover sheets 1 to 5, respectively. Table 1 shows the deviations, the average values of deviations, and the deviations, and Table 2 shows the time required for each sticking, the average values of deviations, and the deviations.

[Evaluation]
In the cover sheets of Examples 1 to 4, the deviations measured at two locations were both small, and it was possible to coat the transdermal absorbable patch preparation so as to be located at the approximate center of the cover sheet. Moreover, the time required for sticking the cover sheet was short, and the sticking efficiency of the cover sheet was improved. On the other hand, in the cover sheet of Comparative Example 1, one shift can be reduced, but the other shift is increased. Also, the time required for pasting was long.

  The cover sheet of the present invention is suitably used for medical applications, and can be particularly suitably used for coating a transdermally absorbable patch preparation.

DESCRIPTION OF SYMBOLS 10 Carrier 20 Support body 30 Adhesive layer 40 Release liner 50 Positioning printing pattern 100 Cover sheet 200 Transdermal absorbable patch preparation

Claims (7)

A cover sheet used for coating a transdermally absorbable patch preparation,
A carrier, a support, an adhesive layer, and a release liner are provided in this order,
The cover sheet in which the carrier has a positioning print pattern corresponding to a predetermined portion of the transdermally absorbable patch preparation on one surface.   The cover sheet according to claim 1, wherein the carrier, the support, and the pressure-sensitive adhesive layer are transparent.   The cover sheet according to claim 1 or 2, wherein a distance between a peripheral edge of the support and the outermost part of the positioning printing pattern is 10 mm to 30 mm.   The cover sheet according to any one of claims 1 to 3, wherein the positioning printing pattern has the same shape as an outline of the transdermally absorbable patch preparation.   The cover sheet according to any one of claims 1 to 3, wherein the positioning printing pattern has two or more portions that coincide with the contour of the transdermally absorbable patch preparation.   The portion of the positioning print pattern that coincides with the contour of the transdermal absorbable patch preparation is point-symmetric with respect to the center of the transdermal absorbable patch preparation and / or with respect to the symmetry axis of the transdermal absorbable patch preparation. The cover sheet according to claim 5, wherein the cover sheet is formed to be line symmetric.   The cover sheet according to claim 6, which has two sets of positioning print patterns formed so as to be point-symmetric and / or line-symmetric.

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