JP2010018546A - Collagenase inhibitor, external preparation for skin, oral composition and food - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a collagenase inhibitor highly safe to a human body, and exhibiting excellent effects, to provide the collagenase inhibitor safely formulated with various kinds of compositions, and exhibiting the excellent effects, and to provide an external preparation for the skin, an oral composition and a food, obtained by formulating the collagenase inhibitor. <P>SOLUTION: The collagenase inhibitor contains an extract of at least one kind of plants selected from the group consisting of Dipterocarpus obtusifolius, Parkia religiosa, Eugenia javanica, Eugenia paniala, Eugenia siamensis, Linociera macrophylla wall and Achras sapotal as an active ingredient. The external preparation for the skin, the oral composition and the food contain the collagenase inhibitor. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a collagenase inhibitor. More specifically, the present invention relates to a collagenase inhibitor containing an extract of a specific plant as an active ingredient. Furthermore, the present invention relates to the use of such a collagenase inhibitor, and more specifically to an external preparation for skin, a composition for oral cavity and a food containing the collagenase inhibitor.

Many studies have been made on the physiology of the skin involving collagen. In skin aging, qualitative and quantitative changes such as collagen fibers, elastin fibers, and acidic mucopolysaccharides, which are dermal matrix components, occur as fibroblast activity decreases. Collagen fibers become stiff due to the formation of abnormal aging crosslinks and lose their inherent elasticity. In addition, elastin fibers are denatured and disintegrated, and elastin with a different amino acid composition is produced in a compensatory manner, resulting in functional impairment. As a result, the skin loses its flexibility and wrinkles and sagging occurs.
In recent years research has progressed and various Matrixin family matrix proteases (MMPs) have been purified that are thought to play an important role in the construction of skin tissue and maintaining homeostasis. Among these matrix proteases, collagenases, namely MMP-1, MMP-8, MMP-13, and MMP-18 have been identified so far. In particular, MMP-1 degrades collagens I and III, which are main components of the skin matrix, and is deeply involved in skin aging. Collagen denaturation and reduction are caused by overexpression of collagenase, a collagenolytic enzyme. Therefore, inhibiting the activity of collagenase gives skin elasticity and elasticity and is important for preventing skin aging.

On the other hand, in the oral cavity region, Porphyromonas gingivalis is involved in the onset and progression of periodontal disease, and it is known that periodontal tissue is destroyed by collagenase produced by the porphyromonas gingivalis. For this reason, it is thought that periodontal disease can be prevented and treated by inhibiting the activity of collagenase.
Conventionally, a substance having a collagenase inhibitory activity has been found, making it an active ingredient of a collagenase inhibitor and its application have been studied. For example, a cacao husk extract that is cacao bean peel (see Patent Document 1), a rose family Onistrawberry extract (see Patent Document 2), lactoferrin (see Patent Document 3), and the like have been proposed. Further, since collagenase is a metalloprotease, metal chelating agents such as diferoxamine, ethylenediamine tetraacetic acid (EDTA) salt, tartaric acid and citric acid are also used as collagenase inhibitors.
Under the circumstances of increasing interest in skin aging and oral hygiene, it is required to find a substance having no side effects, higher safety and excellent collagenase inhibitory action.

JP-A-3-44331 JP 2003-137801 A JP-A-5-186368

  An object of the present invention is to provide a collagenase inhibitor that is highly safe for the human body and can exhibit excellent effects. Another object of the present invention is to provide a collagenase inhibitor that can be safely blended into various compositions and can exhibit excellent effects. The object of the present invention is further to provide a composition containing such a collagenase inhibitor, for example, an external preparation for skin, a composition for oral cavity, and a food.

As a result of intensive studies to achieve the above-mentioned problems, the present inventors have found that an extract of a specific plant has an excellent collagenase activity inhibitory action, and have completed the present invention.
Accordingly, the present invention relates to Dipterocarpus obtusifolius, Parkia religiosa, Eugenia javanica, Eugenia paniala, Eugenia siamensis, and Eugenia siamensis. A collagenase inhibitor characterized by containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Linociera macrophylla wall) and Achras sapotal.
The above-mentioned collagenase inhibitor of the present invention can be blended in various compositions, for example, external preparations for skin, oral compositions, and foods.
Therefore, the present invention is further directed to a skin external preparation containing the collagenase inhibitor, an oral composition containing the collagenase inhibitor, and a food containing the collagenase inhibitor.

The collagenase inhibitor of the present invention comprises an extract from a plant as an active ingredient, exhibits extremely high safety, and exhibits an excellent collagenase activity inhibitory action. The collagenase inhibitor of the present invention can be used as it is in the form of a solvent extract from plants, or can be formulated into various dosage forms.
The collagenase inhibitor of the present invention is useful for the prevention and alleviation of diseases such as living organisms, skin disorders, aging and oral cavity caused by collagenase activity, such as periodontal disease. The collagenase inhibitor of the present invention can also be easily blended into compositions such as external preparations for skin, oral compositions and foods. Therefore, according to the skin external preparation, oral composition and food containing the collagenase inhibitor of the present invention, the collagenase activity inhibitory action of the collagenase inhibitor of the present invention can be enjoyed, and these can be derived from the living body caused by the collagenase activity. It can be used to prevent or reduce diseases such as skin damage, aging, and periodontal disease in the oral cavity.

  Collagenase inhibitors of the present invention include Dipterocarpus obtusifolius, Parkia religiosa, Eugenia javanica, Eugenia paniala, Eugenia macrosia sis. It contains at least one plant extract selected from the group consisting of Linociera macrophylla wall and Achras sapotal, specifically, a solvent extract as an active ingredient.

Dipterocarpus obtusifolius (scientific name: Dipterocarpus obtusifolius) used in the present invention is a plant belonging to the genus Dipterocarpus obtusifolius and grows mainly in Southeast Asia. It has not been known so far that this plant has a collagenase inhibitory action. The bark, root, leaf, flower, fruit, etc. can be used as a raw material for obtaining an extract of Dipterocarpus obtusifolius, but bark is preferably used.
Parkia religiosa (scientific name: Parkia religiosa) is a plant belonging to the genus Parchia, which grows mainly in the tropics. It has not been known so far that this plant has a collagenase inhibitory action. The bark, roots, leaves, flowers, fruits, etc. can be used as the raw material for obtaining the extract of Parkia religiosa, but the pericarp is preferably used.
Eugenia javanica (scientific name: Eugenia javanica) is a plant belonging to the genus Eugenia, which grows mainly from the subtropics to the tropics. It has not been known so far that this plant has a collagenase inhibitory action. As a raw material for obtaining an extract of Eugenia javanica, its bark, roots, leaves, flowers, fruits and the like can be used, but bark is preferably used.

Eugenia paniala (scientific name: Eugenia paniala) is a plant belonging to the genus Eugenia, which grows mainly from the subtropics to the tropics. It has not been known so far that this plant has a collagenase inhibitory action. As a raw material for obtaining an extract of Eugenia paniala, its bark, root, leaf, flower, fruit and the like can be used, but leaves are preferably used.
Eugenia siamensis (scientific name: Eugenia siamensis) is a plant belonging to the genus Eugenia, which grows mainly from the subtropics to the tropics. It has not been known so far that this plant has a collagenase inhibitory action. The bark, root, leaf, flower, fruit, etc. can be used as a raw material for obtaining an extract of Eugenia siamensis, but leaves are preferably used.
Rinociera macrophylla wall (scientific name: linociera macrophylla wall) is a plant belonging to the genus Rinosiella, which grows mainly from the tropics to the temperate zone. It has not been known so far that this plant has a collagenase inhibitory action. As the raw material for obtaining the extract of linociera macrophylla wall, its bark, roots, leaves, flowers, fruits and the like can be used, but the roots are preferably used.
Achras sapotal (scientific name: Achras sapotal) is a plant belonging to the genus Manilkara of the Acetaceae family and grows widely in the rainforest area. It has not been known so far that this plant has a collagenase inhibitory action. Here, as a raw material for obtaining an extract of Achras sapotal, its bark, roots, leaves, flowers, fruits and the like can be used, but leaves are preferably used.
These plant extracts are of very low toxicity.

In the extraction from the plant raw material, the raw material for extraction may be used as it is. However, considering the extraction efficiency, it is desirable to extract the raw material after processing such as chopping, drying, and grinding.
Extraction is performed with a solvent, and examples of the extraction solvent include polar solvents, nonpolar solvents, and mixtures thereof. Examples of polar solvents include water, ethyl ether, ethylene chloride, dioxane, acetone, ethanol, methanol, ethyl acetate, propylene glycol and the like. Examples of nonpolar solvents include n-hexane, petroleum ether, ligroin, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, toluene, benzene and the like. These extraction solvents may be used alone or in combination of two or more. For example, water, ethanol, or a mixture of water and ethanol (for example, water-containing ethanol) can be preferably used.
Moreover, generally the ratio (mass) of an extraction raw material and an extraction solvent is the range of 1-1000 mass parts of extraction solvents with respect to 1 mass part of plant raw materials, Preferably it is the range of 1-100 mass parts. Yes, more preferably in the range of 1 to 20 parts by weight, of which about 10 parts by weight is desirable.

The extraction temperature is desirably about 5 ° C. to the boiling point of the extraction solvent. For example, it is convenient to carry out the extraction at room temperature (about 10 to 30 ° C.). The extraction time is not particularly limited, but is preferably about 1 hour to 14 days.
Further, with respect to the extraction method, for example, immersion extraction with an extraction solvent at a temperature from about 5 ° C. to the boiling point of the extraction solvent can be mentioned, and the extraction can be performed under normal pressure. A stirring operation may be performed during the immersion. In addition, operations such as pressurization, heating, steam pressure, centrifugation, filtration, and pressing may be performed.
The extraction operation can be repeated with the raw material residue after the first extraction operation.
The plant extract which is an active ingredient of the collagenase inhibitor of the present invention may be extracted from one kind of plant raw material, or two or more parts of one kind of plant may be used as the extraction raw material. More than one kind of plant may be mixed as an extraction raw material to perform the extraction operation, or two or more kinds of plant extracts may be mixed.

The plant extract thus obtained can be used as it is depending on the situation, or it can be concentrated or purified by a known means. For example, the obtained extract may be subjected to treatments such as concentration, dilution and filtration, decolorization with activated carbon and the like, and deodorization treatment. Further, the extract may be processed into a dried product by concentration, drying, spray drying, freeze drying or the like.
The plant extract can be used in various forms such as an active ingredient concentrate (eg, concentrated extract), paste, gel, solid dried product and / or diluted product. For example, the extract is directly vacuum (frozen) dried, concentrated under reduced pressure, then vacuum (frozen) dried, or concentrated under reduced pressure, and then fractionated with various solvents to purify collagenase-inhibiting components, The extract may be obtained by (freeze) drying, or by concentration and purification using column chromatography in which an extract is loaded onto the column and then vacuum (freeze) dried.
In addition, the process of obtaining said plant extract is also possible to select and use the thing of the shape according to the objective and a concentrated thing, stopping operation suitably in the middle process, without performing to the last drying process. .
The extract obtained by the above extraction operation may be used as an extract by distilling off the solvent. Alternatively, in some cases, particularly when the extraction solvent is non-toxic water, ethanol, or the like, the extract may be used as it is without distilling off the solvent.

The collagenase inhibitor of the present invention may have a composition of the above plant extract alone, which is an active ingredient, or may contain other ingredients in addition to the active ingredient.
The collagenase inhibitor according to the present invention can be prepared in various dosage forms. For example, it can be prepared in a desired form such as a solution in which a plant extract, which is an active ingredient of the collagenase inhibitor of the present invention, is dissolved in an appropriate solvent, or a paste, powder, block, or the like. In this case, the collagenase inhibitor of the present invention has a very stable collagenase inhibitory action in various forms such as a solid state, an aqueous solution state, and a state dissolved in an organic solvent, and is therefore limited to the selection of the dosage form. There is no.
The collagenase inhibitor of the present invention can be used in a wide range of compositions, and the present invention is particularly directed to an external preparation for skin, an oral composition, and food.

  The skin external preparation, oral composition, and food dosage form containing the collagenase inhibitor of the present invention are arbitrary, and include ampoules, capsules, powders, granules, tablets, solids, liquids, and gels. Various dosage forms such as pastes, emulsions, creams, ointments, sheets, mousses, powder dispersions, and multilayers can be formed.

Specifically, as a skin external preparation containing the collagenase inhibitor of the present invention, basic cosmetics such as creams, emulsions, lotions, cosmetics, ointments, oils, packs, lotions, gels; undermakeups, foundations, etc. Skin cleansing agents such as soap, body soap, cleanser, cleanser, cleansing cream, cleansing lotion and cleansing milk; hair cosmetics such as shampoo, rinse, treatment, hair tonic and hair restorer; Examples include bath additives; deodorants such as antiperspirants and deodorant sticks; and drugs for external use. The dosage form is not particularly limited as long as it is conventionally used for external use on the skin.
In the external preparation for skin of the present invention, the amount of the plant extract, which is an active ingredient of a collagenase inhibitor, is suitably 0.001 to 10% by mass, particularly 0.01 to 1% by mass of the whole composition. It is desirable to do.
In the external preparation for skin of the present invention, other collagenase inhibitors other than the above-mentioned collagenase inhibitors may be used in combination.

The skin external preparation of the present invention includes components usually used in skin external preparations such as cosmetics and pharmaceuticals, for example, oily ingredients, surfactants (synthetic and natural), moisturizers, thickeners, antiseptic / disinfectants, A powder component, an ultraviolet absorber, a whitening agent, an antioxidant, an alcohol, a colorant, an aqueous component, water, a physiologically active component, and the like can be appropriately blended as necessary.
Here, as the oil component, for example, olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, palm oil, palm oil, cacao oil, meadow foam oil, sheer butter, tea tree oil, avocado oil, Oils derived from plants such as macadamia nut oil and plant-derived squalane; Oils and fats derived from animals such as mink oil and turtle oil; waxes such as beeswax, canauba wax, rice wax, lanolin; liquid paraffin, petrolatum, paraffin wax, squalane Hydrocarbons: fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, cis-11-eicosenoic acid; higher alcohols such as lauryl alcohol, cetanol, stearyl alcohol; isopropyl myristate, oleic acid Butyl, 2-ethyl hex Jiruguriseraido, higher fatty acid octyldodecyl (octyl stearate dodecyl and the like), and the synthetic esters and synthetic triglycerides such like.

Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyethylene glycol fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene Nonionic surfactants such as hydrogenated castor oil, polyoxyethylene sorbitol fatty acid ester, fatty acid alkanolamide; fatty acid salt, alkyl sulfate, alkyl benzene sulfonate, polyoxyethylene alkyl ether sulfate, polyoxyethylene fatty amine sulfate, Polyoxyethylene alkyl phenyl ether sulfate, polyoxyethylene alkyl ether phosphate, sodium N-lauroyl sarcosine Anionic surfactants of: quaternary ammonium salts, primary to tertiary fatty amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-hydroxyethylimidazolinium salts, N, N-dialkyl Cationic surfactants such as morpholinium salts and polyethylene polyamine fatty acid amide salts; N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N-trialkyl-N-alkyleneammoniocarboxyl Amphoteric surfactants such as betaine, N-acidaminopropyl-N ′, N′-dimethyl-N′-β-hydroxypropylammoniosulfobetaine, and coconut oil fatty acid amidopropylbetaine can be used.
Also, stevia derivatives such as enzyme-treated stevia, lecithin and its derivatives, lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented cereals (wheat, beans, millet, etc.) etc. You can also.

  Examples of humectants include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidonecarboxylate, and sugars such as trehalose, lactic acid bacteria fermented rice, and mucopolysaccharides. (For example, hyaluronic acid and its derivatives, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, NMF related substances, lactic acid, urea, higher fatty acid octyldodecyl, seaweed extract, seafood Examples include derived collagen and derivatives thereof, various amino acids and derivatives thereof.

  Examples of thickeners include, for example, algaic acid, agar, carrageenan, fucoidan, etc. Synthetic polymers such as gums, cellulose derivatives such as carboxymethylcellulose, hydroxyethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic acid / methacrylic acid copolymer; hyaluronic acid and its derivatives, polyglutamic acid and its derivatives, etc. Is mentioned.

Examples of the antiseptic / disinfectant include urea; paraoxybenzoates such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate; dibutylhydroxytoluene, phenoxyethanol, dichlorophene, chlorhexidine hydrochloride, Examples include benzalkonium, salicylic acid, ethanol, undecylenic acid, phenols, isopropylmethylphenol, jamal (imidazodenyl urea), 1,2-pentanediol, various essential oils, and bark distillate.
Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk powder, and cellulose. System powder, grains (rice, wheat, corn, millet, etc.) powder, beans (soybean, red beans, etc.) powder, etc.

  Examples of ultraviolet absorbers include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, 2-ethylhexyl paramethoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4 -Methoxybenzophenone-5-sulfonate, 4-tertiarybutyl-4-methoxybenzoylmethane, 2- (2-hydroxy-5-methylphenyl) benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. .

Examples of physiologically active ingredients include whitening ingredients such as t-cycloamino acid derivatives, kojic acid and derivatives thereof, ascorbic acid and derivatives thereof, hydroquinone derivatives, ellagic acid and derivatives thereof, resorcinol derivatives, pine bark extract, etc. -Dihydroxybenzoic acid derivatives, nicotine derivatives, vitamin E and its derivatives, α-hydroxy acids and the like.
Examples of the kojic acid derivative include kojic acid sugar derivatives such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid butyrate, kojic acid ethers, kojic acid glucoside, and the like. Examples of the acid derivative include L-ascorbic acid-2-phosphate sodium, L-ascorbic acid-2-phosphate magnesium, L-ascorbic acid-2-sulfate sodium, L-ascorbic acid-2-sulfate ester. Ascorbic acid ester salts such as lunamagnesium, L-ascorbic acid-2-glucoside (2-O-α-D-glucopyranosyl-L-ascorbic acid), L-ascorbic acid-5-glucoside (5-O-α-D) -Glucopyranosyl-L-ascorbic acid) L-ascorbic acid sugar derivatives, such as L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, etc. Ascorbic acid tetra fatty acid esters, 3-O-ethylascorbic acid, L-ascorbic acid-2-phosphate-6-O-palmitate sodium, etc., as hydroquinone derivatives, arbutin (hydroquinone-β-D-glucopyranoside) , Α-arbutin (hydroquinone-α-D-glucopyranoside) and the like, and as the resorcinol derivative, for example, 4-n-butylresorcinol, 4-n-butylresorcinol, 4-isoamylresorcinol and the like are 2,5-dihydroxybenzoic acid. Examples of derivatives include 2,5- Acetoxybenzoic acid, 2-acetoxy-5-dihydroxybenzoic acid, 2-hydroxy-5-propionyloxybenzoic acid and the like are nicotinic acid derivatives such as nicotinic acid amide and benzyl nicotinate, and vitamin E derivatives as For example, vitamin E nicotinate, vitamin E linoleate and the like, and α-hydroxy acids include, for example, lactic acid, malic acid, succinic acid, citric acid, α-hydroxyoctanoic acid and the like.

  Others, disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, sequestering agents such as gluconic acid, caffeine, tannin, verapamil, tranexamic acid and its derivatives, licorice extract, orgon Extracts, aloe extract, various herbal medicines, drugs such as tocopherol acetate, glycyrrhizic acid and its derivatives or salts thereof, sugars such as glucose, fructose, mannose, sucrose, trehalose, pH adjusters such as potassium hydroxide and citric acid As a solvent, ethanol or water can be appropriately blended.

  The skin external preparation of the present invention can be produced according to a conventional method according to its form and shape, and the above-mentioned plant extract may be blended in an appropriate production process.

The oral composition containing the collagenase inhibitor of the present invention includes, for example, toothpaste, liquid dentifrice, liquid dentifrice, dentifrice such as powder dentifrice, oral ointment, patch, mouthwash, mouthwash It can be provided in various forms such as an agent, gargle, gargle tablet, injectable preparation, spray, oral gel, oral paste, film, troche, tablet, chewable, chewing gum and the like.
In the composition for oral cavity of the present invention, the amount of the plant extract which is an active ingredient of the collagenase inhibitor is suitably 0.001 to 10% by mass, particularly 0.01 to 1% by mass of the whole composition. It is desirable that
In the composition for oral cavity of this invention, you may use together other collagenase inhibitors other than said collagenase inhibitor.

In the oral composition of the present invention, components usually used in oral preparations, such as abrasives, binders, thickeners, surfactants, fragrances, preservatives, bactericides, antibacterial agents, anti-cariogenic agents, A flame retardant, a whitening agent, a moisturizer, an antioxidant, an oil component, an alcohol, a powder component, a colorant, an aqueous component, water, and the like can be appropriately blended as necessary.
Specifically, for dentifrices such as toothpastes, crystalline silica, amorphous silica, hydrous silicic acid, silicic anhydride, other silica-based abrasives, zeolite, aluminosilicate, aluminum oxide, water Aluminum oxide, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide (titanium dioxide), calcium dihydrogen phosphate, calcium hydrogen phosphate anhydrous, dicalcium phosphate dihydrate, heavy calcium carbonate, light calcium carbonate, etc. Is mentioned. When using an abrasive | polishing agent, the compounding quantity is the range of 3-99 mass% generally.

Examples of binders include carrageenan, carboxymethylcellulose, carboxymethylcellulose sodium, methylcellulose, hydroxymethylcellulose, carboxymethylhydroxymethylcellulose sodium, hydroxypropylcellulose, cellulose derivatives such as crystalline cellulose, alkali metal alginates such as sodium alginate, propylene glycol alginate, Gums such as xanthan gum, tragacanth gum, karaya gum, gum arabic, etc., synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, gelling silica, gelling aluminum silica, vegant, laponite, etc. An inorganic binder is mentioned. When using a binder, generally the compounding quantity is the range of 0.5-10 mass%.
Examples of thickeners include sorbit, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, maltite, lactit and the like. The blending amount of the thickener is generally in the range of 1 to 50% by mass.

  Examples of the surfactant include, for example, sodium lauryl sulfate, sodium α-olefin sulfonate, sodium dodecylbenzene sulfonate, sodium N-lauroyl sarcosine, N-acyl glutamate, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, Examples include polyoxyethylene polyoxypropylene block copolymers, alkyl glucosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and alkyldimethylamine oxide. The amount of the surfactant is generally up to about 5% by mass.

Further, as optional components, for example, sweeteners such as xylitol, sodium saccharin, stevioside, glycyrrhizin, perilartin, thaumatin, aspartylphenylalanine methyl ester, p-methoxycinamic amic aldenide, sucrose, fructose, sodium cyclamate; spearmint oil, peppermint Perfumes such as oil, wintergreen oil, sassafras oil, clove oil, eucalyptus oil, sage oil, mayonnaise oil, thyme oil, lemon oil, orange oil, 1-menthol, carvone, anethole, eugenol, thymol, methyl salicylate; benzoic acid , Sodium benzoate, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, p-hydroxybutyl benzoic acid, low Preservatives such as fatty acid monoglycerides; bactericides such as quaternary ammonium salts, triclosan, alkyldiaminoethylglycine hydrochloride, phenols, isopropylmethylphenol; epsilon aminocaproic acid; dextranase, amylase, protease, mutanase, lytic enzyme, lysozyme Enzymes such as sodium monofluorophosphate, potassium monofluorophosphate, fluorides such as sodium fluoride, ammonium fluoride, stannous fluoride; chlorhexidine salts, dihydrocholesterol, glycyrrhizin salts, dipotassium glycyrrhizinate, glycyrrhetinic acid, Chlorophyll, copper chlorophyllin sodium, caropeptide, vitamins, tocopherol acetate, DL-α-tocopherol, azulene, lysozyme chloride, sorbic acid, azure Xidine, hinokitiol, cetylpyridinium chloride, alkylglycine, alkyldiaminoethylglycine salt, allantoin, tranexamic acid, water-soluble primary or secondary phosphate, sodium chloride, anticalculus agent, anti-plaque agent, potassium nitrate, aluminum lactate, Examples of the pH adjusting agent (sodium hydroxide, citric acid, citrate, etc.) and water, ethanol and the like can be given as solvents.
In addition, the addition amount of these arbitrary components can be made into a normal amount in the range which does not prevent this invention.

  The composition for oral cavity of the present invention can be produced according to a conventional method according to its form and shape, and the above-mentioned plant extract may be blended in an appropriate production process.

The food containing the collagenase inhibitor of the present invention is not particularly limited, and examples thereof include various food forms such as chewing gum, candy, candy, gummy candy, tablet, and powdered juice.
The food of the present invention can be produced by appropriately blending ingredients according to the properties of the target food together with the above-described plant extract. Examples of ingredients used in the production of the food include sweeteners such as gum base, sugar, isomaltose, maltose, corn syrup, starch syrup, palatinose and maltose, flavors, gums such as gum arabic, gelatin, excipients, etc. Is mentioned.
In the food of the present invention, the amount of the plant extract, which is an active ingredient of a collagenase inhibitor, is suitably 0.001 to 10% by mass, particularly 0.01 to 1% by mass of the whole composition. Is desirable.
In the food of the present invention, other collagenase inhibitors other than the above-described collagenase inhibitors may be used in combination.

EXAMPLES Next, the present invention will be specifically described with reference to examples, but the present invention is not limited thereto.
<Example 1>
Preparation of Dipterocarpus obtusifolius Extract 10 g of Dipterocarpus obtusifolius bark was added to 100 g of 70% ethanol solution at room temperature (20 ° C.). Soaked extraction was performed. After 24 hours, the residue was removed by filtration to obtain an extract.
<Example 2>
Preparation of Extract of Parkia religiosa 100 ml of 70% ethanol solution was added to 10 g of dried skin of Parkia religiosa, and immersion extraction was performed at room temperature (20 ° C.). After 24 hours, the residue was removed by filtration to obtain an extract.
<Example 3>
Preparation of Eugenia javanica extract 100 g of 70% ethanol solution was added to 10 g of dried Eugenia javanica bark, and immersion extraction was performed at room temperature (20 ° C.). After 24 hours, the residue was removed by filtration to obtain an extract.

<Example 4>
Preparation of Eugenia paniala extract 100 mL of 70% ethanol solution was added to 10 g of dried Eugenia paniala leaves, and immersion extraction was performed at room temperature (20 ° C.). After 24 hours, the residue was removed by filtration to obtain an extract.
<Example 5>
Preparation of Eugenia siamensis extract 100 g of 70% ethanol solution was added to 10 g of dried Eugenia siamensis leaves, and immersion extraction was performed at room temperature (20 ° C.). After 24 hours, the residue was removed by filtration to obtain an extract.
<Example 6>
Preparation of extract of linociera macrophylla wall (10g) Add 100mL of 70% ethanol solution to 10g of dried linociera macrophylla wall root and extract at room temperature (20 ℃). went. After 24 hours, the residue was removed by filtration to obtain an extract.
<Example 7>
Preparation of Achras sapotal extract 100 g of 70% ethanol solution was added to 10 g of dried Achras sapotal leaves, and immersion extraction was performed at room temperature (20 ° C.). After 24 hours, the residue was removed by filtration to obtain an extract.

<Test example>
Test of Collagenase Activity Inhibitory Action Using the extracts obtained in Examples 1 to 7 as a sample, collagenase activity inhibitory action was measured using a commercially available collagenase activity measurement kit (collageno kit CLN-100, manufactured by Collagen Technology Training Co., Ltd.). And evaluated.
Specifically, a degradation product produced by reacting with collagenase in the presence of a test sample using fluorescently labeled collagen as a substrate is selectively denatured at 35 ° C., and then extracted with ethanol, and the fluorescence of the extracted degradation product is expressed. By measuring the strength, the inhibition rate of collagenase activity was determined using the decrease rate of collagenase activity of the subject as the inhibition rate.
Measurement of collagenase activity inhibition effect: A collagenase solution (0.3 unit to 0.5 unit / mL, manufactured by Wako Pure Chemical Industries, Ltd.) 100 μL, a fluorescently labeled collagen solution 200 μL, and a test sample 100 μL were mixed to give a total of 400 μL. The reaction was carried out for a time, and the fluorescence intensity of the degradation product was measured after the reaction to calculate the collagenase activity. The test sample was prepared with 0.05 M Tris-HCl buffer (pH 7.5) so that the final concentration was 0.01%. In addition, as a control test, it is known that 100 μL of 0.05 M Tris-HCl buffer (pH 7.5) is used as a control instead of the above test sample solution, and that it has collagenase inhibitory activity as a comparative test instead of the test sample. Collagenase activity was measured in the same manner as described above using ethylenediaminetetraacetic acid (EDTA), which is a non-organic substance. The collagenase activity inhibition rate was determined by the following formula.
Collagenase activity inhibition rate (%) = (1− (S−S _b / C−B)) × 100
(S: fluorescence intensity of the test sample when collagenase is added S _b : fluorescence intensity of the test sample when collagenase is not added C: fluorescence intensity of the control when collagenase is added B: fluorescence intensity of the control when collagenase is not added)
The results are shown in Table 1.

  As is clear from the results in Table 1, the collagenase inhibitory effect of the active ingredient of the collagenase inhibitor of the present invention was stronger than the collagenase inhibitory effect of EDTA.

Various plant extracts were blended according to the following formulation, and the skin external preparation, oral composition and food of the present invention were prepared by a conventional method. The unit of the amount is mass%.
The present invention is not limited to the following formulation examples.
<Example 8>
Lotion Toner lotion was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (60) hydrogenated castor oil 0.3%
2. Glycerol 3.0%
3. Dipropylene glycol 2.0%
4). Ethanol 5.0%
5). Extract of Example 1 0.1%
6). Methylparaben 0.2%
7). Purified water balance
100%
Ingredients 1-7 were mixed and dissolved uniformly to obtain a skin lotion.

<Example 9>
Lotion Toner lotion was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (60) hydrogenated castor oil 0.3%
2. Glycerol 3.0%
3. Dipropylene glycol 2.0%
4). Ethanol 5.0%
5). Extract of Example 2 0.1%
6). Methylparaben 0.2%
7). Purified water balance
100%
Ingredients 1-7 were mixed and dissolved uniformly to obtain a skin lotion.

<Example 10>
Lotion Toner lotion was prepared according to the following composition. The total amount was adjusted to 100 with purified water.
1. Polyoxyethylene (60) hydrogenated castor oil 0.3%
2. Glycerol 3.0%
3. Dipropylene glycol 2.0%
4). Ethanol 5.0%
5). Extract of Example 3 0.1%
6). Methylparaben 0.2%
7). Purified water balance
100%
Ingredients 1-7 were mixed and dissolved uniformly to obtain a skin lotion.

<Example 11>
Lotion Toner lotion was prepared according to the following composition. The total amount was adjusted to 100 with purified water.
1. Polyoxyethylene (60) hydrogenated castor oil 0.3%
2. Glycerol 3.0%
3. Dipropylene glycol 2.0%
4). Ethanol 5.0%
5). Extract of Example 4 0.1%
6). Methylparaben 0.2%
7). Purified water balance
100%
Ingredients 1-7 were mixed and dissolved uniformly to obtain a skin lotion.

<Example 12>
Lotion Toner lotion was prepared according to the following composition. The total amount was adjusted to 100 with purified water.
1. Polyoxyethylene (60) hydrogenated castor oil 0.3%
2. Glycerol 3.0%
3. Dipropylene glycol 2.0%
4). Ethanol 5.0%
5). Extract of Example 5 0.1%
6). Methylparaben 0.2%
7). Purified water balance
100%
Ingredients 1-7 were mixed and dissolved uniformly to obtain a skin lotion.

<Example 13>
Lotion Toner lotion was prepared according to the following composition. The total amount was adjusted to 100 with purified water.
1. Polyoxyethylene (60) hydrogenated castor oil 0.3%
2. Glycerol 3.0%
3. Dipropylene glycol 2.0%
4). Ethanol 5.0%
5). Extract of Example 6 0.1%
6). Methylparaben 0.2%
7). Purified water balance
100%
Ingredients 1-7 were mixed and dissolved uniformly to obtain a skin lotion.

<Example 14>
Lotion Toner lotion was prepared according to the following composition. The total amount was adjusted to 100 with purified water.
1. Polyoxyethylene (60) hydrogenated castor oil 0.3%
2. Glycerol 3.0%
3. Dipropylene glycol 2.0%
4). Ethanol 5.0%
5). Extract of Example 7 0.1%
6). Methylparaben 0.2%
7). Purified water balance
100%
Ingredients 1-7 were mixed and dissolved uniformly to obtain a skin lotion.

<Example 15>
Cream A cream was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (10) sodium alkyl ether phosphate 4.5%
2. Polyoxyethylene (3) alkyl ether 2.0%
3. Lipophilic glyceryl monostearate 2.0%
4). Cetanol 2.0%
5). Squalane 5.0%
6). Liquid paraffin 10.0%
7.1,3-butylene glycol 5.0%
8). Hydrolyzed soy protein 0.5%
9. Sodium hyaluronate (1%) 1.0%
10. Methylparaben 0.2%
11. Propylparaben 0.1%
12 Extract of Example 1 0.1%
13. Purified water balance
100%
Ingredients 1-7, 10 and 11 were heated and mixed at 80 ° C., and 13 heated to the same temperature was gradually added to emulsify. Cool to 40 ° C. and add ingredients 8, 9 and 12 to emulsify. The solution was cooled to around 40 ° C. to obtain a cream.

<Example 16>
Cream A cream was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (10) sodium alkyl ether phosphate 4.5%
2. Polyoxyethylene (3) alkyl ether 2.0%
3. Lipophilic glyceryl monostearate 2.0%
4). Cetanol 2.0%
5). Squalane 5.0%
6). Liquid paraffin 10.0%
7.1,3-butylene glycol 5.0%
8). Hydrolyzed soy protein 0.5%
9. Sodium hyaluronate (1%) 1.0%
10. Methylparaben 0.2%
11. Propylparaben 0.1%
12 Extract of Example 2 0.1%
13. Purified water balance
100%
Ingredients 1-7, 10 and 11 were heated and mixed at 80 ° C., and 13 heated to the same temperature was gradually added to emulsify. Cool to 40 ° C. and add ingredients 8, 9 and 12 to emulsify. The solution was cooled to around 40 ° C. to obtain a cream.

<Example 17>
Cream A cream was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (10) sodium alkyl ether phosphate 4.5%
2. Polyoxyethylene (3) alkyl ether 2.0%
3. Lipophilic glyceryl monostearate 2.0%
4). Cetanol 2.0%
5). Squalane 5.0%
6). Liquid paraffin 10.0%
7.1,3-butylene glycol 5.0%
8). Hydrolyzed soy protein 0.5%
9. Sodium hyaluronate (1%) 1.0%
10. Methylparaben 0.2%
11. Propylparaben 0.1%
12 Extract of Example 3 0.1%
13. Purified water balance
100%
Ingredients 1-7, 10 and 11 were heated and mixed at 80 ° C., and 13 heated to the same temperature was gradually added to emulsify. Cool to 40 ° C. and add ingredients 8, 9 and 12 to emulsify. The solution was cooled to around 40 ° C. to obtain a cream.

<Example 18>
Cream A cream was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (10) sodium alkyl ether phosphate 4.5%
2. Polyoxyethylene (3) alkyl ether 2.0%
3. Lipophilic glyceryl monostearate 2.0%
4). Cetanol 2.0%
5). Squalane 5.0%
6). Liquid paraffin 10.0%
7.1,3-butylene glycol 5.0%
8). Hydrolyzed soy protein 0.5%
9. Sodium hyaluronate (1%) 1.0%
10. Methylparaben 0.2%
11. Propylparaben 0.1%
12 Extract of Example 4 0.1%
13. Purified water balance
100%
Ingredients 1-7, 10 and 11 were heated and mixed at 80 ° C., and 13 heated to the same temperature was gradually added to emulsify. Cool to 40 ° C. and add ingredients 8, 9 and 12 to emulsify. The solution was cooled to around 40 ° C. to obtain a cream.

<Example 19>
Cream A cream was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (10) sodium alkyl ether phosphate 4.5%
2. Polyoxyethylene (3) alkyl ether 2.0%
3. Lipophilic glyceryl monostearate 2.0%
4). Cetanol 2.0%
5). Squalane 5.0%
6). Liquid paraffin 10.0%
7.1,3-butylene glycol 5.0%
8). Hydrolyzed soy protein 0.5%
9. Sodium hyaluronate (1%) 1.0%
10. Methylparaben 0.2%
11. Propylparaben 0.1%
12 Extract of Example 5 0.1%
13. Purified water balance
100%
Ingredients 1-7, 10 and 11 were heated and mixed at 80 ° C., and 13 heated to the same temperature was gradually added to emulsify. Cool to 40 ° C. and add ingredients 8, 9 and 12 to emulsify. The solution was cooled to around 40 ° C. to obtain a cream.

<Example 20>
Cream A cream was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (10) sodium alkyl ether phosphate 4.5%
2. Polyoxyethylene (3) alkyl ether 2.0%
3. Lipophilic glyceryl monostearate 2.0%
4). Cetanol 2.0%
5). Squalane 5.0%
6). Liquid paraffin 10.0%
7.1,3-butylene glycol 5.0%
8). Hydrolyzed soy protein 0.5%
9. Sodium hyaluronate (1%) 1.0%
10. Methylparaben 0.2%
11. Propylparaben 0.1%
12 Extract of Example 6 0.1%
13. Purified water balance
100%
Ingredients 1-7, 10 and 11 were heated and mixed at 80 ° C., and 13 heated to the same temperature was gradually added to emulsify. Cool to 40 ° C. and add ingredients 8, 9 and 12 to emulsify. The solution was cooled to around 40 ° C. to obtain a cream.

<Example 21>
Cream A cream was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (10) sodium alkyl ether phosphate 4.5%
2. Polyoxyethylene (3) alkyl ether 2.0%
3. Lipophilic glyceryl monostearate 2.0%
4). Cetanol 2.0%
5). Squalane 5.0%
6). Liquid paraffin 10.0%
7.1,3-butylene glycol 5.0%
8). Hydrolyzed soy protein 0.5%
9. Sodium hyaluronate (1%) 1.0%
10. Methylparaben 0.2%
11. Propylparaben 0.1%
12 Extract of Example 7 0.1%
13. Purified water balance
100%
Ingredients 1-7, 10 and 11 were heated and mixed at 80 ° C., and 13 heated to the same temperature was gradually added to emulsify. Cool to 40 ° C. and add ingredients 8, 9 and 12 to emulsify. The solution was cooled to around 40 ° C. to obtain a cream.

<Example 22>
Emulsion An emulsion was prepared with the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (20) behenyl ether 1.2%
2. Tetraoleic acid polyoxyethylene (60) sorbit 1.2%
3. Lipophilic glyceryl monostearate 1.0%
4). Cetostearyl alcohol 0.5%
5.1,3-butylene glycol 6.0%
6). Liquid paraffin 8.0%
7). Plant-based squalane 3.0%
8). Isocetyl myristate 2.0%
9. Phenoxyethanol 0.5%
10. Methylparaben 0.3%
11. Propylparaben 0.1%
12 Carboxyvinyl polymer 0.1%
13. Xanthan gum (1% aqueous solution) 10.0%
14 Potassium hydroxide (10% aqueous solution) 0.47%
15. Extract of Example 1 0.1%
16. Purified water balance
100%
Components 1 to 11 were uniformly heated and mixed at 80 ° C., and component 16 at the same temperature was gradually added and emulsified. After component 12 was added and mixed, component 14 was added to make it uniform. Subsequently, it cooled to 50 degreeC, the components 13 and 15 were added, and it cooled to room temperature vicinity, and was set as the emulsion.

<Example 23>
Emulsion An emulsion was prepared with the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (20) behenyl ether 1.2%
2. Tetraoleic acid polyoxyethylene (60) sorbit 1.2%
3. Lipophilic glyceryl monostearate 1.0%
4). Cetostearyl alcohol 0.5%
5.1,3-butylene glycol 6.0%
6). Liquid paraffin 8.0%
7). Plant-based squalane 3.0%
8). Isocetyl myristate 2.0%
9. Phenoxyethanol 0.5%
10. Methylparaben 0.3%
11. Propylparaben 0.1%
12 Carboxyvinyl polymer 0.1%
13. Xanthan gum (1% aqueous solution) 10.0%
14 Potassium hydroxide (10% aqueous solution) 0.47%
15. Extract of Example 2 0.1%
16. Purified water balance
100%
Components 1 to 11 were uniformly heated and mixed at 80 ° C., and component 16 at the same temperature was gradually added and emulsified. After component 12 was added and mixed, component 14 was added to make it uniform. Subsequently, it cooled to 50 degreeC, the components 13 and 15 were added, and it cooled to room temperature vicinity, and was set as the emulsion.

<Example 24>
Emulsion An emulsion was prepared with the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (20) behenyl ether 1.2%
2. Tetraoleic acid polyoxyethylene (60) sorbit 1.2%
3. Lipophilic glyceryl monostearate 1.0%
4). Cetostearyl alcohol 0.5%
5.1,3-butylene glycol 6.0%
6). Liquid paraffin 8.0%
7). Plant-based squalane 3.0%
8). Isocetyl myristate 2.0%
9. Phenoxyethanol 0.5%
10. Methylparaben 0.3%
11. Propylparaben 0.1%
12 Carboxyvinyl polymer 0.1%
13. Xanthan gum (1% aqueous solution) 10.0%
14 Potassium hydroxide (10% aqueous solution) 0.47%
15. Extract of Example 3 0.1%
16. Purified water balance
100%
Components 1 to 11 were uniformly heated and mixed at 80 ° C., and component 16 at the same temperature was gradually added and emulsified. After component 12 was added and mixed, component 14 was added to make it uniform. Subsequently, it cooled to 50 degreeC, the components 13 and 15 were added, and it cooled to room temperature vicinity, and was set as the emulsion.

<Example 25>
Emulsion An emulsion was prepared with the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (20) behenyl ether 1.2%
2. Tetraoleic acid polyoxyethylene (60) sorbit 1.2%
3. Lipophilic glyceryl monostearate 1.0%
4). Cetostearyl alcohol 0.5%
5.1,3-butylene glycol 6.0%
6). Liquid paraffin 8.0%
7). Plant-based squalane 3.0%
8). Isocetyl myristate 2.0%
9. Phenoxyethanol 0.5%
10. Methylparaben 0.3%
11. Propylparaben 0.1%
12 Carboxyvinyl polymer 0.1%
13. Xanthan gum (1% aqueous solution) 10.0%
14 Potassium hydroxide (10% aqueous solution) 0.47%
15. Extract of Example 4 0.1%
16. Purified water balance
100%
Components 1 to 11 were uniformly heated and mixed at 80 ° C., and component 16 at the same temperature was gradually added and emulsified. After component 12 was added and mixed, component 14 was added to make it uniform. Subsequently, it cooled to 50 degreeC, the components 13 and 15 were added, and it cooled to room temperature vicinity, and was set as the emulsion.

<Example 26>
Emulsion An emulsion was prepared with the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (20) behenyl ether 1.2%
2. Tetraoleic acid polyoxyethylene (60) sorbit 1.2%
3. Lipophilic glyceryl monostearate 1.0%
4). Cetostearyl alcohol 0.5%
5.1,3-butylene glycol 6.0%
6). Liquid paraffin 8.0%
7). Plant-based squalane 3.0%
8). Isocetyl myristate 2.0%
9. Phenoxyethanol 0.5%
10. Methylparaben 0.3%
11. Propylparaben 0.1%
12 Carboxyvinyl polymer 0.1%
13. Xanthan gum (1% aqueous solution) 10.0%
14 Potassium hydroxide (10% aqueous solution) 0.47%
15. Extract of Example 5 0.1%
16. Purified water balance
100%
Components 1 to 11 were uniformly heated and mixed at 80 ° C., and component 16 at the same temperature was gradually added and emulsified. After component 12 was added and mixed, component 14 was added to make it uniform. Subsequently, it cooled to 50 degreeC, the components 13 and 15 were added, and it cooled to room temperature vicinity, and was set as the emulsion.

<Example 27>
Emulsion An emulsion was prepared with the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (20) behenyl ether 1.2%
2. Tetraoleic acid polyoxyethylene (60) sorbit 1.2%
3. Lipophilic glyceryl monostearate 1.0%
4). Cetostearyl alcohol 0.5%
5.1,3-butylene glycol 6.0%
6). Liquid paraffin 8.0%
7). Plant-based squalane 3.0%
8). Isocetyl myristate 2.0%
9. Phenoxyethanol 0.5%
10. Methylparaben 0.3%
11. Propylparaben 0.1%
12 Carboxyvinyl polymer 0.1%
13. Xanthan gum (1% aqueous solution) 10.0%
14 Potassium hydroxide (10% aqueous solution) 0.47%
15. Extract of Example 6 0.1%
16. Purified water balance
100%
Components 1 to 11 were uniformly heated and mixed at 80 ° C., and component 16 at the same temperature was gradually added and emulsified. After component 12 was added and mixed, component 14 was added to make it uniform. Subsequently, it cooled to 50 degreeC, the components 13 and 15 were added, and it cooled to room temperature vicinity, and was set as the emulsion.

<Example 28>
Emulsion An emulsion was prepared with the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (20) behenyl ether 1.2%
2. Tetraoleic acid polyoxyethylene (60) sorbit 1.2%
3. Lipophilic glyceryl monostearate 1.0%
4). Cetostearyl alcohol 0.5%
5.1,3-butylene glycol 6.0%
6). Liquid paraffin 8.0%
7). Plant-based squalane 3.0%
8). Isocetyl myristate 2.0%
9. Phenoxyethanol 0.5%
10. Methylparaben 0.3%
11. Propylparaben 0.1%
12 Carboxyvinyl polymer 0.1%
13. Xanthan gum (1% aqueous solution) 10.0%
14 Potassium hydroxide (10% aqueous solution) 0.47%
15. Extract of Example 7 0.1%
16. Purified water balance
100%
Components 1 to 11 were uniformly heated and mixed at 80 ° C., and component 16 at the same temperature was gradually added and emulsified. After component 12 was added and mixed, component 14 was added to make it uniform. Subsequently, it cooled to 50 degreeC, the components 13 and 15 were added, and it cooled to room temperature vicinity, and was set as the emulsion.

<Example 29>
Face washing foam A face washing foam was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Myristic acid 20.0%
2. Palmitic acid 5.0%
3. Lauric acid diethanolamide 3.5%
4). Polyethylene glycol distearate (140) 1.0%
5). Polyethylene glycol 400 5.0%
6). N-lauroylmethyl taurine sodium solution 8.0%
7). Glycerin 20.0%
8). Sorbit solution 3.0%
9. Edetate disodium 0.05%
10. Dibutylhydroxytoluene 0.05%
11. Potassium hydroxide 5.3%
12 Isopropyl methylphenol 0.2%
13. Fragrance 0.1%
14 Extract of Example 1 0.1%
15. Purified water balance
100%
Components 1 to 10 and 12 were uniformly heated and mixed at 80 ° C., and a solution obtained by dissolving component 11 in component 15 was gradually added thereto. After sufficiently stirring, the mixture was cooled to 45 ° C., components 13 and 14 were added, and the mixture was cooled to around room temperature to obtain a face-washing foam.

<Example 30>
Face washing foam A face washing foam was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Myristic acid 20.0%
2. Palmitic acid 5.0%
3. Lauric acid diethanolamide 3.5%
4). Polyethylene glycol distearate (140) 1.0%
5). Polyethylene glycol 400 5.0%
6). N-lauroylmethyl taurine sodium solution 8.0%
7). Glycerin 20.0%
8). Sorbit solution 3.0%
9. Edetate disodium 0.05%
10. Dibutylhydroxytoluene 0.05%
11. Potassium hydroxide 5.3%
12 Isopropyl methylphenol 0.2%
13. Fragrance 0.1%
14 Extract of Example 2 0.1%
15. Purified water balance
100%
Components 1 to 10 and 12 were uniformly heated and mixed at 80 ° C., and a solution obtained by dissolving component 11 in component 15 was gradually added thereto. After sufficiently stirring, the mixture was cooled to 45 ° C., components 13 and 14 were added, and the mixture was cooled to around room temperature to obtain a face-washing foam.

<Example 31>
Face washing foam A face washing foam was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Myristic acid 20.0%
2. Palmitic acid 5.0%
3. Lauric acid diethanolamide 3.5%
4). Polyethylene glycol distearate (140) 1.0%
5). Polyethylene glycol 400 5.0%
6). N-lauroylmethyl taurine sodium solution 8.0%
7). Glycerin 20.0%
8). Sorbit solution 3.0%
9. Edetate disodium 0.05%
10. Dibutylhydroxytoluene 0.05%
11. Potassium hydroxide 5.3%
12 Isopropyl methylphenol 0.2%
13. Fragrance 0.1%
14 Extract of Example 3 0.1%
15. Purified water balance
100%
Components 1 to 10 and 12 were uniformly heated and mixed at 80 ° C., and a solution obtained by dissolving component 11 in component 15 was gradually added thereto. After sufficiently stirring, the mixture was cooled to 45 ° C., components 13 and 14 were added, and the mixture was cooled to around room temperature to obtain a face-washing foam.

<Example 32>
Face washing foam A face washing foam was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Myristic acid 20.0%
2. Palmitic acid 5.0%
3. Lauric acid diethanolamide 3.5%
4). Polyethylene glycol distearate (140) 1.0%
5). Polyethylene glycol 400 5.0%
6). N-lauroylmethyl taurine sodium solution 8.0%
7). Glycerin 20.0%
8). Sorbit solution 3.0%
9. Edetate disodium 0.05%
10. Dibutylhydroxytoluene 0.05%
11. Potassium hydroxide 5.3%
12 Isopropyl methylphenol 0.2%
13. Fragrance 0.1%
14 Extract of Example 4 0.1%
15. Purified water balance
100%
Components 1 to 10 and 12 were uniformly heated and mixed at 80 ° C., and a solution obtained by dissolving component 11 in component 15 was gradually added thereto. After sufficiently stirring, the mixture was cooled to 45 ° C., components 13 and 14 were added, and the mixture was cooled to around room temperature to obtain a face-washing foam.

<Example 33>
Face washing foam A face washing foam was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Myristic acid 20.0%
2. Palmitic acid 5.0%
3. Lauric acid diethanolamide 3.5%
4). Polyethylene glycol distearate (140) 1.0%
5). Polyethylene glycol 400 5.0%
6). N-lauroylmethyl taurine sodium solution 8.0%
7). Glycerin 20.0%
8). Sorbit solution 3.0%
9. Edetate disodium 0.05%
10. Dibutylhydroxytoluene 0.05%
11. Potassium hydroxide 5.3%
12 Isopropyl methylphenol 0.2%
13. Fragrance 0.1%
14 Extract of Example 5 0.1%
15. Purified water balance
100%
Components 1 to 10 and 12 were uniformly heated and mixed at 80 ° C., and a solution obtained by dissolving component 11 in component 15 was gradually added thereto. After sufficiently stirring, the mixture was cooled to 45 ° C., components 13 and 14 were added, and the mixture was cooled to around room temperature to obtain a face-washing foam.

<Example 34>
Face washing foam A face washing foam was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Myristic acid 20.0%
2. Palmitic acid 5.0%
3. Lauric acid diethanolamide 3.5%
4). Polyethylene glycol distearate (140) 1.0%
5). Polyethylene glycol 400 5.0%
6). N-lauroylmethyl taurine sodium solution 8.0%
7). Glycerin 20.0%
8). Sorbit solution 3.0%
9. Edetate disodium 0.05%
10. Dibutylhydroxytoluene 0.05%
11. Potassium hydroxide 5.3%
12 Isopropyl methylphenol 0.2%
13. Fragrance 0.1%
14 Extract of Example 6 0.1%
15. Purified water balance
100%
Components 1 to 10 and 12 were uniformly heated and mixed at 80 ° C., and a solution obtained by dissolving component 11 in component 15 was gradually added thereto. After sufficiently stirring, the mixture was cooled to 45 ° C., components 13 and 14 were added, and the mixture was cooled to around room temperature to obtain a face-washing foam.

<Example 35>
Face washing foam A face washing foam was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Myristic acid 20.0%
2. Palmitic acid 5.0%
3. Lauric acid diethanolamide 3.5%
4). Polyethylene glycol distearate (140) 1.0%
5). Polyethylene glycol 400 5.0%
6). N-lauroylmethyl taurine sodium solution 8.0%
7). Glycerin 20.0%
8). Sorbit solution 3.0%
9. Edetate disodium 0.05%
10. Dibutylhydroxytoluene 0.05%
11. Potassium hydroxide 5.3%
12 Isopropyl methylphenol 0.2%
13. Fragrance 0.1%
14 Extract of Example 7 0.1%
15. Purified water balance
100%
Components 1 to 10 and 12 were uniformly heated and mixed at 80 ° C., and a solution obtained by dissolving component 11 in component 15 was gradually added thereto. After sufficiently stirring, the mixture was cooled to 45 ° C., components 13 and 14 were added, and the mixture was cooled to around room temperature to obtain a face-washing foam.

<Example 36>
Hair shampoo A hair shampoo was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (3) sodium lauryl ether sulfate 20.0%
2. Palm oil fatty acid amidopropyl betaine solution 10.0%
3. Lauric acid diethanolamide 3.5%
4). Ethylene glycol distearate 1.0%
5). Lauroyl sarcosine sodium solution 8.0%
6). Jojoba oil 0.2%
7). Glycerin 1.0%
8). Methylparaben 0.2%
9. Edetate disodium 0.1%
10. Tocopherol acetate 0.05%
11. Citric acid appropriate amount12. Cationized cellulose (1% aqueous solution) 20.0%
13. Fragrance 0.2%
14 Extract of Example 1 0.1%
15. Purified water balance
100%
Ingredients 1 to 10 were uniformly heated and mixed at 75 ° C., and ingredient 15 heated to the same temperature was gradually added thereto. Next, components 11 and 12 were added and mixed uniformly, then cooled to 50 ° C., components 13 and 14 were added, and cooled to near room temperature to obtain a hair shampoo.

<Example 37>
Hair shampoo A hair shampoo was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (3) sodium lauryl ether sulfate 20.0%
2. Palm oil fatty acid amidopropyl betaine solution 10.0%
3. Lauric acid diethanolamide 3.5%
4). Ethylene glycol distearate 1.0%
5). Lauroyl sarcosine sodium solution 8.0%
6). Jojoba oil 0.2%
7). Glycerin 1.0%
8). Methylparaben 0.2%
9. Edetate disodium 0.1%
10. Tocopherol acetate 0.05%
11. Citric acid appropriate amount12. Cationized cellulose (1% aqueous solution) 20.0%
13. Fragrance 0.2%
14 Extract of Example 2 0.1%
15. Purified water balance
100%
Ingredients 1 to 10 were uniformly heated and mixed at 75 ° C., and ingredient 15 heated to the same temperature was gradually added thereto. Next, components 11 and 12 were added and mixed uniformly, then cooled to 50 ° C., components 13 and 14 were added, and cooled to near room temperature to obtain a hair shampoo.

<Example 38>
Hair shampoo A hair shampoo was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (3) sodium lauryl ether sulfate 20.0%
2. Palm oil fatty acid amidopropyl betaine solution 10.0%
3. Lauric acid diethanolamide 3.5%
4). Ethylene glycol distearate 1.0%
5). Lauroyl sarcosine sodium solution 8.0%
6). Jojoba oil 0.2%
7). Glycerin 1.0%
8). Methylparaben 0.2%
9. Edetate disodium 0.1%
10. Tocopherol acetate 0.05%
11. Citric acid appropriate amount12. Cationized cellulose (1% aqueous solution) 20.0%
13. Fragrance 0.2%
14 Extract of Example 3 0.1%
15. Purified water balance
100%
Ingredients 1 to 10 were uniformly heated and mixed at 75 ° C., and ingredient 15 heated to the same temperature was gradually added thereto. Next, components 11 and 12 were added and mixed uniformly, then cooled to 50 ° C., components 13 and 14 were added, and cooled to near room temperature to obtain a hair shampoo.

<Example 39>
Hair shampoo A hair shampoo was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (3) sodium lauryl ether sulfate 20.0%
2. Palm oil fatty acid amidopropyl betaine solution 10.0%
3. Lauric acid diethanolamide 3.5%
4). Ethylene glycol distearate 1.0%
5). Lauroyl sarcosine sodium solution 8.0%
6). Jojoba oil 0.2%
7). Glycerin 1.0%
8). Methylparaben 0.2%
9. Edetate disodium 0.1%
10. Tocopherol acetate 0.05%
11. Citric acid appropriate amount12. Cationized cellulose (1% aqueous solution) 20.0%
13. Fragrance 0.2%
14 Extract of Example 4 0.1%
15. Purified water balance
100%
Ingredients 1 to 10 were uniformly heated and mixed at 75 ° C., and ingredient 15 heated to the same temperature was gradually added thereto. Next, components 11 and 12 were added and mixed uniformly, then cooled to 50 ° C., components 13 and 14 were added, and cooled to near room temperature to obtain a hair shampoo.

<Example 40>
Hair shampoo A hair shampoo was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (3) sodium lauryl ether sulfate 20.0%
2. Palm oil fatty acid amidopropyl betaine solution 10.0%
3. Lauric acid diethanolamide 3.5%
4). Ethylene glycol distearate 1.0%
5). Lauroyl sarcosine sodium solution 8.0%
6). Jojoba oil 0.2%
7). Glycerin 1.0%
8). Methylparaben 0.2%
9. Edetate disodium 0.1%
10. Tocopherol acetate 0.05%
11. Citric acid appropriate amount12. Cationized cellulose (1% aqueous solution) 20.0%
13. Fragrance 0.2%
14 Extract of Example 5 0.1%
15. Purified water balance
100%
Ingredients 1 to 10 were uniformly heated and mixed at 75 ° C., and ingredient 15 heated to the same temperature was gradually added thereto. Next, components 11 and 12 were added and mixed uniformly, then cooled to 50 ° C., components 13 and 14 were added, and cooled to near room temperature to obtain a hair shampoo.

<Example 41>
Hair shampoo A hair shampoo was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (3) sodium lauryl ether sulfate 20.0%
2. Palm oil fatty acid amidopropyl betaine solution 10.0%
3. Lauric acid diethanolamide 3.5%
4). Ethylene glycol distearate 1.0%
5). Lauroyl sarcosine sodium solution 8.0%
6). Jojoba oil 0.2%
7). Glycerin 1.0%
8). Methylparaben 0.2%
9. Edetate disodium 0.1%
10. Tocopherol acetate 0.05%
11. Citric acid appropriate amount12. Cationized cellulose (1% aqueous solution) 20.0%
13. Fragrance 0.2%
14 Extract of Example 6 0.1%
15. Purified water balance
100%
Ingredients 1 to 10 were uniformly heated and mixed at 75 ° C., and ingredient 15 heated to the same temperature was gradually added thereto. Next, components 11 and 12 were added and mixed uniformly, then cooled to 50 ° C., components 13 and 14 were added, and cooled to near room temperature to obtain a hair shampoo.

<Example 42>
Hair shampoo A hair shampoo was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (3) sodium lauryl ether sulfate 20.0%
2. Palm oil fatty acid amidopropyl betaine solution 10.0%
3. Lauric acid diethanolamide 3.5%
4). Ethylene glycol distearate 1.0%
5). Lauroyl sarcosine sodium solution 8.0%
6). Jojoba oil 0.2%
7). Glycerin 1.0%
8). Methylparaben 0.2%
9. Edetate disodium 0.1%
10. Tocopherol acetate 0.05%
11. Citric acid appropriate amount12. Cationized cellulose (1% aqueous solution) 20.0%
13. Fragrance 0.2%
14 Extract of Example 7 0.1%
15. Purified water balance
100%
Ingredients 1 to 10 were uniformly heated and mixed at 75 ° C., and ingredient 15 heated to the same temperature was gradually added thereto. Next, components 11 and 12 were added and mixed uniformly, then cooled to 50 ° C., components 13 and 14 were added, and cooled to near room temperature to obtain a hair shampoo.

<Example 43>
Hair restorer A hair restorer was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (40) hydrogenated castor oil 0.5%
2. Olive oil 0.1%
3. Dipropylene glycol 8.0%
4). Ethanol 23.0%
5). Extract of Example 1 0.1%
6). Methylparaben 0.2%
7). Fragrance 0.1%
8). Purified water balance
100%
Ingredients 1-8 were mixed and dissolved uniformly to obtain a hair restorer.

<Example 44>
Hair restorer A hair restorer was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (40) hydrogenated castor oil 0.5%
2. Olive oil 0.1%
3. Dipropylene glycol 8.0%
4). Ethanol 23.0%
5). Extract of Example 2 0.1%
6). Methylparaben 0.2%
7). Fragrance 0.1%
8). Purified water balance
100%
Ingredients 1-8 were mixed and dissolved uniformly to obtain a hair restorer.

<Example 45>
Hair restorer A hair restorer was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (40) hydrogenated castor oil 0.5%
2. Olive oil 0.1%
3. Dipropylene glycol 8.0%
4). Ethanol 23.0%
5). Extract of Example 3 0.1%
6). Methylparaben 0.2%
7). Fragrance 0.1%
8). Purified water balance
100%
Ingredients 1-8 were mixed and dissolved uniformly to obtain a hair restorer.

<Example 46>
Hair restorer A hair restorer was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (40) hydrogenated castor oil 0.5%
2. Olive oil 0.1%
3. Dipropylene glycol 8.0%
4). Ethanol 23.0%
5). Extract of Example 4 0.1%
6). Methylparaben 0.2%
7). Fragrance 0.1%
8). Purified water balance
100%
Ingredients 1-8 were mixed and dissolved uniformly to obtain a hair restorer.

<Example 47>
Hair restorer A hair restorer was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (40) hydrogenated castor oil 0.5%
2. Olive oil 0.1%
3. Dipropylene glycol 8.0%
4). Ethanol 23.0%
5). Extract of Example 5 0.1%
6). Methylparaben 0.2%
7). Fragrance 0.1%
8). Purified water balance
100%
Ingredients 1-8 were mixed and dissolved uniformly to obtain a hair restorer.

<Example 48>
Hair restorer A hair restorer was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (40) hydrogenated castor oil 0.5%
2. Olive oil 0.1%
3. Dipropylene glycol 8.0%
4). Ethanol 23.0%
5). Extract of Example 6 0.1%
6). Methylparaben 0.2%
7). Fragrance 0.1%
8). Purified water balance
100%
Ingredients 1-8 were mixed and dissolved uniformly to obtain a hair restorer.

<Example 49>
Hair restorer A hair restorer was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Polyoxyethylene (40) hydrogenated castor oil 0.5%
2. Olive oil 0.1%
3. Dipropylene glycol 8.0%
4). Ethanol 23.0%
5). Extract of Example 7 0.1%
6). Methylparaben 0.2%
7). Fragrance 0.1%
8). Purified water balance
100%
Ingredients 1-8 were mixed and dissolved uniformly to obtain a hair restorer.

<Example 50>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Calcium hydrogen phosphate anhydrate 20.0%
2. Calcium hydrogen phosphate dihydrate 20.0%
3. Silica anhydride 5.0%
4). Carrageenan 0.7%
5). Sodium carboxymethylcellulose 0.3%
6). Glycerin 20.0%
7.70% sorbite solution 10.0%
8). Methyl paraoxybenzoate 0.1%
9. Triclosan 0.1%
10. Saccharin sodium 0.1%
11. Sodium lauryl sulfate 1.5%
12 DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 1 0.1%
15. Purified water balance
100%

<Example 51>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Calcium hydrogen phosphate anhydrate 20.0%
2. Calcium hydrogen phosphate dihydrate 20.0%
3. Silica anhydride 5.0%
4). Carrageenan 0.7%
5). Sodium carboxymethylcellulose 0.3%
6). Glycerin 20.0%
7.70% sorbite solution 10.0%
8). Methyl paraoxybenzoate 0.1%
9. Triclosan 0.1%
10. Saccharin sodium 0.1%
11. Sodium lauryl sulfate 1.5%
12 DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 2 0.1%
15. Purified water balance
100%

<Example 52>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Calcium hydrogen phosphate anhydrate 20.0%
2. Calcium hydrogen phosphate dihydrate 20.0%
3. Silica anhydride 5.0%
4). Carrageenan 0.7%
5). Sodium carboxymethylcellulose 0.3%
6). Glycerin 20.0%
7.70% sorbite solution 10.0%
8). Methyl paraoxybenzoate 0.1%
9. Triclosan 0.1%
10. Saccharin sodium 0.1%
11. Sodium lauryl sulfate 1.5%
12 DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 3 0.1%
15. Purified water balance
100%

<Example 53>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Calcium hydrogen phosphate anhydrate 20.0%
2. Calcium hydrogen phosphate dihydrate 20.0%
3. Silica anhydride 5.0%
4). Carrageenan 0.7%
5). Sodium carboxymethylcellulose 0.3%
6). Glycerin 20.0%
7.70% sorbite solution 10.0%
8). Methyl paraoxybenzoate 0.1%
9. Triclosan 0.1%
10. Saccharin sodium 0.1%
11. Sodium lauryl sulfate 1.5%
12 DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 4 0.1%
15. Purified water balance
100%

<Example 54>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Calcium hydrogen phosphate anhydrate 20.0%
2. Calcium hydrogen phosphate dihydrate 20.0%
3. Silica anhydride 5.0%
4). Carrageenan 0.7%
5). Sodium carboxymethylcellulose 0.3%
6). Glycerin 20.0%
7.70% sorbite solution 10.0%
8). Methyl paraoxybenzoate 0.1%
9. Triclosan 0.1%
10. Saccharin sodium 0.1%
11. Sodium lauryl sulfate 1.5%
12 DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 5 0.1%
15. Purified water balance
100%

<Example 55>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Calcium hydrogen phosphate anhydrate 20.0%
2. Calcium hydrogen phosphate dihydrate 20.0%
3. Silica anhydride 5.0%
4). Carrageenan 0.7%
5). Sodium carboxymethylcellulose 0.3%
6). Glycerin 20.0%
7.70% sorbite solution 10.0%
8). Methyl paraoxybenzoate 0.1%
9. Triclosan 0.1%
10. Saccharin sodium 0.1%
11. Sodium lauryl sulfate 1.5%
12 DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 6 0.1%
15. Purified water balance
100%

<Example 56>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Calcium hydrogen phosphate anhydrate 20.0%
2. Calcium hydrogen phosphate dihydrate 20.0%
3. Silica anhydride 5.0%
4). Carrageenan 0.7%
5). Sodium carboxymethylcellulose 0.3%
6). Glycerin 20.0%
7.70% sorbite solution 10.0%
8). Methyl paraoxybenzoate 0.1%
9. Triclosan 0.1%
10. Saccharin sodium 0.1%
11. Sodium lauryl sulfate 1.5%
12 DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 7 0.1%
15. Purified water balance
100%

<Example 57>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Silica anhydride 20.0%
2. Titanium dioxide 0.5%
3. Carrageenan 1.0%
4). Propylene glycol 3.0%
5.70% sorbite solution 20.0%
6). Glycerin 20.0%
7). Methyl paraoxybenzoate 0.1%
8). Sodium monofluorophosphate 0.05%
9. Cetylpyridinium chloride 0.1%
10. Sodium lauryl sulfate 1.7%
11. Lauroyl sarcosine sodium 0.3%
12 Copper chlorophyllin sodium 0.05%
13. DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 1 0.1%
15. Fragrance 1.0%
16. Purified water balance
100%

<Example 58>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Silica anhydride 20.0%
2. Titanium dioxide 0.5%
3. Carrageenan 1.0%
4). Propylene glycol 3.0%
5.70% sorbite solution 20.0%
6). Glycerin 20.0%
7). Methyl paraoxybenzoate 0.1%
8). Sodium monofluorophosphate 0.05%
9. Cetylpyridinium chloride 0.1%
10. Sodium lauryl sulfate 1.7%
11. Lauroyl sarcosine sodium 0.3%
12 Copper chlorophyllin sodium 0.05%
13. DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 2 0.1%
15. Fragrance 1.0%
16. Purified water balance
100%

<Example 59>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Silica anhydride 20.0%
2. Titanium dioxide 0.5%
3. Carrageenan 1.0%
4). Propylene glycol 3.0%
5.70% sorbite solution 20.0%
6). Glycerin 20.0%
7). Methyl paraoxybenzoate 0.1%
8). Sodium monofluorophosphate 0.05%
9. Cetylpyridinium chloride 0.1%
10. Sodium lauryl sulfate 1.7%
11. Lauroyl sarcosine sodium 0.3%
12 Copper chlorophyllin sodium 0.05%
13. DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 3 0.1%
15. Fragrance 1.0%
16. Purified water balance
100%

<Example 60>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Silica anhydride 20.0%
2. Titanium dioxide 0.5%
3. Carrageenan 1.0%
4). Propylene glycol 3.0%
5.70% sorbite solution 20.0%
6). Glycerin 20.0%
7). Methyl paraoxybenzoate 0.1%
8). Sodium monofluorophosphate 0.05%
9. Cetylpyridinium chloride 0.1%
10. Sodium lauryl sulfate 1.7%
11. Lauroyl sarcosine sodium 0.3%
12 Copper chlorophyllin sodium 0.05%
13. DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 4 0.1%
15. Fragrance 1.0%
16. Purified water balance
100%

<Example 61>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Silica anhydride 20.0%
2. Titanium dioxide 0.5%
3. Carrageenan 1.0%
4). Propylene glycol 3.0%
5.70% sorbite solution 20.0%
6). Glycerin 20.0%
7). Methyl paraoxybenzoate 0.1%
8). Sodium monofluorophosphate 0.05%
9. Cetylpyridinium chloride 0.1%
10. Sodium lauryl sulfate 1.7%
11. Lauroyl sarcosine sodium 0.3%
12 Copper chlorophyllin sodium 0.05%
13. DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 5 0.1%
15. Fragrance 1.0%
16. Purified water balance
100%

<Example 62>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Silica anhydride 20.0%
2. Titanium dioxide 0.5%
3. Carrageenan 1.0%
4). Propylene glycol 3.0%
5.70% sorbite solution 20.0%
6). Glycerin 20.0%
7). Methyl paraoxybenzoate 0.1%
8). Sodium monofluorophosphate 0.05%
9. Cetylpyridinium chloride 0.1%
10. Sodium lauryl sulfate 1.7%
11. Lauroyl sarcosine sodium 0.3%
12 Copper chlorophyllin sodium 0.05%
13. DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 6 0.1%
15. Fragrance 1.0%
16. Purified water balance
100%

<Example 63>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Silica anhydride 20.0%
2. Titanium dioxide 0.5%
3. Carrageenan 1.0%
4). Propylene glycol 3.0%
5.70% sorbite solution 20.0%
6). Glycerin 20.0%
7). Methyl paraoxybenzoate 0.1%
8). Sodium monofluorophosphate 0.05%
9. Cetylpyridinium chloride 0.1%
10. Sodium lauryl sulfate 1.7%
11. Lauroyl sarcosine sodium 0.3%
12 Copper chlorophyllin sodium 0.05%
13. DL-α-tocopherol 0.1%
13. Polyethylene glycol 1.0%
14 Extract of Example 7 0.1%
15. Fragrance 1.0%
16. Purified water balance
100%

<Example 64>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Aluminum hydroxide 30.0%
2. Silica anhydride 5.0%
3. Sodium chloride 10.0%
4). Sodium carboxymethylcellulose 1.0%
5). Glycerin 20.0%
6). Sodium lauryl sulfate 1.8%
7). Isopropylmethylphenol 0.02%
8). Tocopherol acetate 0.1%
9. Polyoxyethylene hydrogenated castor oil 3.0%
10. Ethyl paraoxybenzoate 0.1%
11. DL-α-tocopherol 0.1%
12 Polyethylene glycol 1.0%
13. Extract of Example 1 0.1%
14 Fragrance 1.0%
15. Purified water balance
100%

<Example 65>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Aluminum hydroxide 30.0%
2. Silica anhydride 5.0%
3. Sodium chloride 10.0%
4). Sodium carboxymethylcellulose 1.0%
5). Glycerin 20.0%
6). Sodium lauryl sulfate 1.8%
7). Isopropylmethylphenol 0.02%
8). Tocopherol acetate 0.1%
9. Polyoxyethylene hydrogenated castor oil 3.0%
10. Ethyl paraoxybenzoate 0.1%
11. DL-α-tocopherol 0.1%
12 Polyethylene glycol 1.0%
13. Extract of Example 2 0.1%
14 Fragrance 1.0%
15. Purified water balance
100%

<Example 66>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Aluminum hydroxide 30.0%
2. Silica anhydride 5.0%
3. Sodium chloride 10.0%
4). Sodium carboxymethylcellulose 1.0%
5). Glycerin 20.0%
6). Sodium lauryl sulfate 1.8%
7). Isopropylmethylphenol 0.02%
8). Tocopherol acetate 0.1%
9. Polyoxyethylene hydrogenated castor oil 3.0%
10. Ethyl paraoxybenzoate 0.1%
11. DL-α-tocopherol 0.1%
12 Polyethylene glycol 1.0%
13. Extract of Example 3 0.1%
14 Fragrance 1.0%
15. Purified water balance
100%

<Example 67>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Aluminum hydroxide 30.0%
2. Silica anhydride 5.0%
3. Sodium chloride 10.0%
4). Sodium carboxymethylcellulose 1.0%
5). Glycerin 20.0%
6). Sodium lauryl sulfate 1.8%
7). Isopropylmethylphenol 0.02%
8). Tocopherol acetate 0.1%
9. Polyoxyethylene hydrogenated castor oil 3.0%
10. Ethyl paraoxybenzoate 0.1%
11. DL-α-tocopherol 0.1%
12 Polyethylene glycol 1.0%
13. Extract of Example 4 0.1%
14 Fragrance 1.0%
15. Purified water balance
100%

<Example 68>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Aluminum hydroxide 30.0%
2. Silica anhydride 5.0%
3. Sodium chloride 10.0%
4). Sodium carboxymethylcellulose 1.0%
5). Glycerin 20.0%
6). Sodium lauryl sulfate 1.8%
7). Isopropylmethylphenol 0.02%
8). Tocopherol acetate 0.1%
9. Polyoxyethylene hydrogenated castor oil 3.0%
10. Ethyl paraoxybenzoate 0.1%
11. DL-α-tocopherol 0.1%
12 Polyethylene glycol 1.0%
13. Extract of Example 5 0.1%
14 Fragrance 1.0%
15. Purified water balance
100%

<Example 69>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Aluminum hydroxide 30.0%
2. Silica anhydride 5.0%
3. Sodium chloride 10.0%
4). Sodium carboxymethylcellulose 1.0%
5). Glycerin 20.0%
6). Sodium lauryl sulfate 1.8%
7). Isopropylmethylphenol 0.02%
8). Tocopherol acetate 0.1%
9. Polyoxyethylene hydrogenated castor oil 3.0%
10. Ethyl paraoxybenzoate 0.1%
11. DL-α-tocopherol 0.1%
12 Polyethylene glycol 1.0%
13. Extract of Example 6 0.1%
14 Fragrance 1.0%
15. Purified water balance
100%

<Example 70>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Aluminum hydroxide 30.0%
2. Silica anhydride 5.0%
3. Sodium chloride 10.0%
4). Sodium carboxymethylcellulose 1.0%
5). Glycerin 20.0%
6). Sodium lauryl sulfate 1.8%
7). Isopropylmethylphenol 0.02%
8). Tocopherol acetate 0.1%
9. Polyoxyethylene hydrogenated castor oil 3.0%
10. Ethyl paraoxybenzoate 0.1%
11. DL-α-tocopherol 0.1%
12 Polyethylene glycol 1.0%
13. Extract of Example 7 0.1%
14 Fragrance 1.0%
15. Purified water balance
100%

<Example 71>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Hydroxypropyl cellulose 3.0%
2. Polyethylene glycol 25.0%
3. 1,3-butylene glycol 30.6%
4). Crystalline cellulose 5.0%
5). Calcium hydrogen phosphate anhydrate 20.0%
6). Calcium hydrogen phosphate dihydrate 20.0%
7). Sodium lauryl sulfate 1.0%
8). Cetylpyridinium chloride 0.05%
9. Tocopherol acetate 0.1%
10. Polyoxyethylene hydrogenated castor oil 3.0%
11. Propyl paraoxybenzoate 0.1%
12 Dipotassium glycyrrhizinate 0.05%
13. Zeolite 1.0%
14 Extract of Example 1 0.1%
15. Fragrance 1.0%
100%

<Example 72>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Hydroxypropyl cellulose 3.0%
2. Polyethylene glycol 25.0%
3. 1,3-butylene glycol 30.6%
4). Crystalline cellulose 5.0%
5). Calcium hydrogen phosphate anhydrate 20.0%
6). Calcium hydrogen phosphate dihydrate 20.0%
7). Sodium lauryl sulfate 1.0%
8). Cetylpyridinium chloride 0.05%
9. Tocopherol acetate 0.1%
10. Polyoxyethylene hydrogenated castor oil 3.0%
11. Propyl paraoxybenzoate 0.1%
12 Dipotassium glycyrrhizinate 0.05%
13. Zeolite 1.0%
14 Extract of Example 2 0.1%
15. Fragrance 1.0%
100%

<Example 73>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Hydroxypropyl cellulose 3.0%
2. Polyethylene glycol 25.0%
3. 1,3-butylene glycol 30.6%
4). Crystalline cellulose 5.0%
5). Calcium hydrogen phosphate anhydrate 20.0%
6). Calcium hydrogen phosphate dihydrate 20.0%
7). Sodium lauryl sulfate 1.0%
8). Cetylpyridinium chloride 0.05%
9. Tocopherol acetate 0.1%
10. Polyoxyethylene hydrogenated castor oil 3.0%
11. Propyl paraoxybenzoate 0.1%
12 Dipotassium glycyrrhizinate 0.05%
13. Zeolite 1.0%
14 Extract of Example 3 0.1%
15. Fragrance 1.0%
100%

<Example 74>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Hydroxypropyl cellulose 3.0%
2. Polyethylene glycol 25.0%
3. 1,3-butylene glycol 30.6%
4). Crystalline cellulose 5.0%
5). Calcium hydrogen phosphate anhydrate 20.0%
6). Calcium hydrogen phosphate dihydrate 20.0%
7). Sodium lauryl sulfate 1.0%
8). Cetylpyridinium chloride 0.05%
9. Tocopherol acetate 0.1%
10. Polyoxyethylene hydrogenated castor oil 3.0%
11. Propyl paraoxybenzoate 0.1%
12 Dipotassium glycyrrhizinate 0.05%
13. Zeolite 1.0%
14 Extract of Example 4 0.1%
15. Fragrance 1.0%
100%

<Example 75>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Hydroxypropyl cellulose 3.0%
2. Polyethylene glycol 25.0%
3. 1,3-butylene glycol 30.6%
4). Crystalline cellulose 5.0%
5). Calcium hydrogen phosphate anhydrate 20.0%
6). Calcium hydrogen phosphate dihydrate 20.0%
7). Sodium lauryl sulfate 1.0%
8). Cetylpyridinium chloride 0.05%
9. Tocopherol acetate 0.1%
10. Polyoxyethylene hydrogenated castor oil 3.0%
11. Propyl paraoxybenzoate 0.1%
12 Dipotassium glycyrrhizinate 0.05%
13. Zeolite 1.0%
14 Extract of Example 5 0.1%
15. Fragrance 1.0%
100%

<Example 76>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Hydroxypropyl cellulose 3.0%
2. Polyethylene glycol 25.0%
3. 1,3-butylene glycol 30.6%
4). Crystalline cellulose 5.0%
5). Calcium hydrogen phosphate anhydrate 20.0%
6). Calcium hydrogen phosphate dihydrate 20.0%
7). Sodium lauryl sulfate 1.0%
8). Cetylpyridinium chloride 0.05%
9. Tocopherol acetate 0.1%
10. Polyoxyethylene hydrogenated castor oil 3.0%
11. Propyl paraoxybenzoate 0.1%
12 Dipotassium glycyrrhizinate 0.05%
13. Zeolite 1.0%
14 Extract of Example 6 0.1%
15. Fragrance 1.0%
100%

<Example 77>
Toothpaste A toothpaste was prepared according to a conventional method with the following composition.
1. Hydroxypropyl cellulose 3.0%
2. Polyethylene glycol 25.0%
3. 1,3-butylene glycol 30.6%
4). Crystalline cellulose 5.0%
5). Calcium hydrogen phosphate anhydrate 20.0%
6). Calcium hydrogen phosphate dihydrate 20.0%
7). Sodium lauryl sulfate 1.0%
8). Cetylpyridinium chloride 0.05%
9. Tocopherol acetate 0.1%
10. Polyoxyethylene hydrogenated castor oil 3.0%
11. Propyl paraoxybenzoate 0.1%
12 Dipotassium glycyrrhizinate 0.05%
13. Zeolite 1.0%
14 Extract of Example 7 0.1%
15. Fragrance 1.0%
100%

<Example 78>
Liquid dentifrice A liquid dentifrice was prepared according to a conventional method with the following composition.
1. Silica anhydride 10.0%
2. Xanthan gum 1.0%
2. Glycerin 10.0%
3.70% sorbite solution 20.0%
4). Xylitol 1.0%
5). Ethyl paraoxybenzoate 0.1%
6). Butyl paraoxybenzoate 0.05%
7). Sodium dihydrogen phosphate dihydrate 0.3%
8). Sodium hydroxide 0.05%
9. DL-α-tocopherol 0.1%
10. Polyethylene glycol 1.0%
11. Extract of Example 1 0.1%
12 Fragrance 1.0%
13. Purified water balance
100%

<Example 79>
Liquid dentifrice A liquid dentifrice was prepared according to a conventional method with the following composition.
1. Silica anhydride 10.0%
2. Xanthan gum 1.0%
2. Glycerin 10.0%
3.70% sorbite solution 20.0%
4). Xylitol 1.0%
5). Ethyl paraoxybenzoate 0.1%
6). Butyl paraoxybenzoate 0.05%
7). Sodium dihydrogen phosphate dihydrate 0.3%
8). Sodium hydroxide 0.05%
9. DL-α-tocopherol 0.1%
10. Polyethylene glycol 1.0%
11. Extract of Example 2 0.1%
12 Fragrance 1.0%
13. Purified water balance
100%

<Example 80>
Liquid dentifrice A liquid dentifrice was prepared according to a conventional method with the following composition.
1. Silica anhydride 10.0%
2. Xanthan gum 1.0%
2. Glycerin 10.0%
3.70% sorbite solution 20.0%
4). Xylitol 1.0%
5). Ethyl paraoxybenzoate 0.1%
6). Butyl paraoxybenzoate 0.05%
7). Sodium dihydrogen phosphate dihydrate 0.3%
8). Sodium hydroxide 0.05%
9. DL-α-tocopherol 0.1%
10. Polyethylene glycol 1.0%
11. Extract of Example 3 0.1%
12 Fragrance 1.0%
13. Purified water balance
100%

<Example 81>
Liquid dentifrice A liquid dentifrice was prepared according to a conventional method with the following composition.
1. Silica anhydride 10.0%
2. Xanthan gum 1.0%
2. Glycerin 10.0%
3.70% sorbite solution 20.0%
4). Xylitol 1.0%
5). Ethyl paraoxybenzoate 0.1%
6). Butyl paraoxybenzoate 0.05%
7). Sodium dihydrogen phosphate dihydrate 0.3%
8). Sodium hydroxide 0.05%
9. DL-α-tocopherol 0.1%
10. Polyethylene glycol 1.0%
11. Extract of Example 4 0.1%
12 Fragrance 1.0%
13. Purified water balance
100%

<Example 82>
Liquid dentifrice A liquid dentifrice was prepared according to a conventional method with the following composition.
1. Silica anhydride 10.0%
2. Xanthan gum 1.0%
2. Glycerin 10.0%
3.70% sorbite solution 20.0%
4). Xylitol 1.0%
5). Ethyl paraoxybenzoate 0.1%
6). Butyl paraoxybenzoate 0.05%
7). Sodium dihydrogen phosphate dihydrate 0.3%
8). Sodium hydroxide 0.05%
9. DL-α-tocopherol 0.1%
10. Polyethylene glycol 1.0%
11. Extract of Example 5 0.1%
12 Fragrance 1.0%
13. Purified water balance
100%

<Example 83>
Liquid dentifrice A liquid dentifrice was prepared according to a conventional method with the following composition.
1. Silica anhydride 10.0%
2. Xanthan gum 1.0%
2. Glycerin 10.0%
3.70% sorbite solution 20.0%
4). Xylitol 1.0%
5). Ethyl paraoxybenzoate 0.1%
6). Butyl paraoxybenzoate 0.05%
7). Sodium dihydrogen phosphate dihydrate 0.3%
8). Sodium hydroxide 0.05%
9. DL-α-tocopherol 0.1%
10. Polyethylene glycol 1.0%
11. Extract of Example 6 0.1%
12 Fragrance 1.0%
13. Purified water balance
100%

<Example 84>
Liquid dentifrice A liquid dentifrice was prepared according to a conventional method with the following composition.
1. Silica anhydride 10.0%
2. Xanthan gum 1.0%
2. Glycerin 10.0%
3.70% sorbite solution 20.0%
4). Xylitol 1.0%
5). Ethyl paraoxybenzoate 0.1%
6). Butyl paraoxybenzoate 0.05%
7). Sodium dihydrogen phosphate dihydrate 0.3%
8). Sodium hydroxide 0.05%
9. DL-α-tocopherol 0.1%
10. Polyethylene glycol 1.0%
11. Extract of Example 7 0.1%
12 Fragrance 1.0%
13. Purified water balance
100%

<Example 85>
Mouthwash A mouthwash was prepared according to a conventional method with the following composition.
1. Ethanol 5.0%
2. Polyoxyethylene hydrogenated castor oil 0.5%
3. Glycerin 5.0%
4). Xylitol 25.0%
5). Cetylpyridinium chloride 0.05%
6). Ethyl paraoxybenzoate 0.05%
7). Propyl paraoxybenzoate 0.05%
8). Citric acid 0.03%
9. Sodium citrate 0.12%
10. Yellow No. 4 0.0002%
11. Green No. 3 0.0002%
13. DL-α-tocopherol 0.1%
14 Polyethylene glycol 1.0%
15. Extract of Example 1 0.1%
16. Purified water balance
100%

<Example 86>
Mouthwash A mouthwash was prepared according to a conventional method with the following composition.
1. Ethanol 5.0%
2. Polyoxyethylene hydrogenated castor oil 0.5%
3. Glycerin 5.0%
4). Xylitol 25.0%
5). Cetylpyridinium chloride 0.05%
6). Ethyl paraoxybenzoate 0.05%
7). Propyl paraoxybenzoate 0.05%
8). Citric acid 0.03%
9. Sodium citrate 0.12%
10. Yellow No. 4 0.0002%
11. Green No. 3 0.0002%
13. DL-α-tocopherol 0.1%
14 Polyethylene glycol 1.0%
15. Extract of Example 2 0.1%
16. Purified water balance
100%

<Example 87>
Mouthwash A mouthwash was prepared according to a conventional method with the following composition.
1. Ethanol 5.0%
2. Polyoxyethylene hydrogenated castor oil 0.5%
3. Glycerin 5.0%
4). Xylitol 25.0%
5). Cetylpyridinium chloride 0.05%
6). Ethyl paraoxybenzoate 0.05%
7). Propyl paraoxybenzoate 0.05%
8). Citric acid 0.03%
9. Sodium citrate 0.12%
10. Yellow No. 4 0.0002%
11. Green No. 3 0.0002%
13. DL-α-tocopherol 0.1%
14 Polyethylene glycol 1.0%
15. Extract of Example 3 0.1%
16. Purified water balance
100%

<Example 88>
Mouthwash A mouthwash was prepared according to a conventional method with the following composition.
1. Ethanol 5.0%
2. Polyoxyethylene hydrogenated castor oil 0.5%
3. Glycerin 5.0%
4). Xylitol 25.0%
5). Cetylpyridinium chloride 0.05%
6). Ethyl paraoxybenzoate 0.05%
7). Propyl paraoxybenzoate 0.05%
8). Citric acid 0.03%
9. Sodium citrate 0.12%
10. Yellow No. 4 0.0002%
11. Green No. 3 0.0002%
13. DL-α-tocopherol 0.1%
14 Polyethylene glycol 1.0%
15. Extract of Example 4 0.1%
16. Purified water balance
100%

<Example 89>
Mouthwash A mouthwash was prepared according to a conventional method with the following composition.
1. Ethanol 5.0%
2. Polyoxyethylene hydrogenated castor oil 0.5%
3. Glycerin 5.0%
4). Xylitol 25.0%
5). Cetylpyridinium chloride 0.05%
6). Ethyl paraoxybenzoate 0.05%
7). Propyl paraoxybenzoate 0.05%
8). Citric acid 0.03%
9. Sodium citrate 0.12%
10. Yellow No. 4 0.0002%
11. Green No. 3 0.0002%
13. DL-α-tocopherol 0.1%
14 Polyethylene glycol 1.0%
15. Extract of Example 5 0.1%
16. Purified water balance
100%

<Example 90>
Mouthwash A mouthwash was prepared according to a conventional method with the following composition.
1. Ethanol 5.0%
2. Polyoxyethylene hydrogenated castor oil 0.5%
3. Glycerin 5.0%
4). Xylitol 25.0%
5). Cetylpyridinium chloride 0.05%
6). Ethyl paraoxybenzoate 0.05%
7). Propyl paraoxybenzoate 0.05%
8). Citric acid 0.03%
9. Sodium citrate 0.12%
10. Yellow No. 4 0.0002%
11. Green No. 3 0.0002%
13. DL-α-tocopherol 0.1%
14 Polyethylene glycol 1.0%
15. Extract of Example 6 0.1%
16. Purified water balance
100%

<Example 91>
Mouthwash A mouthwash was prepared according to a conventional method with the following composition.
1. Ethanol 5.0%
2. Polyoxyethylene hydrogenated castor oil 0.5%
3. Glycerin 5.0%
4). Xylitol 25.0%
5). Cetylpyridinium chloride 0.05%
6). Ethyl paraoxybenzoate 0.05%
7). Propyl paraoxybenzoate 0.05%
8). Citric acid 0.03%
9. Sodium citrate 0.12%
10. Yellow No. 4 0.0002%
11. Green No. 3 0.0002%
13. DL-α-tocopherol 0.1%
14 Polyethylene glycol 1.0%
15. Extract of Example 7 0.1%
16. Purified water balance
100%

<Example 92>
Chewing gum A chewing gum was prepared according to the following formulation.
1. Gum base 20.0%
2. Sugar 15.0%
3. Isomaltose 20.0%
4). Maltose 20.0%
5). Corn syrup 12.0%
6). Minamata 11.5%
7). Fragrance 0.5%
8). Extract of Example 1 1.0%
100%

<Example 93>
Chewing gum A chewing gum was prepared according to the following formulation.
1. Gum base 20.0%
2. Sugar 15.0%
3. Isomaltose 20.0%
4). Maltose 20.0%
5). Corn syrup 12.0%
6). Minamata 11.5%
7). Fragrance 0.5%
8). Extract of Example 2 1.0%
100%

<Example 94>
Chewing gum A chewing gum was prepared according to the following formulation.
1. Gum base 20.0%
2. Sugar 15.0%
3. Isomaltose 20.0%
4). Maltose 20.0%
5). Corn syrup 12.0%
6). Minamata 11.5%
7). Fragrance 0.5%
8). Extract of Example 3 1.0%
100%

<Example 95>
Chewing gum A chewing gum was prepared according to the following formulation.
1. Gum base 20.0%
2. Sugar 15.0%
3. Isomaltose 20.0%
4). Maltose 20.0%
5). Corn syrup 12.0%
6). Minamata 11.5%
7). Fragrance 0.5%
8). Extract of Example 4 1.0%
100%

<Example 96>
Chewing gum A chewing gum was prepared according to the following formulation.
1. Gum base 20.0%
2. Sugar 15.0%
3. Isomaltose 20.0%
4). Maltose 20.0%
5). Corn syrup 12.0%
6). Minamata 11.5%
7). Fragrance 0.5%
8). Extract of Example 5 1.0%
100%

<Example 97>
Chewing gum A chewing gum was prepared according to the following formulation.
1. Gum base 20.0%
2. Sugar 15.0%
3. Isomaltose 20.0%
4). Maltose 20.0%
5). Corn syrup 12.0%
6). Minamata 11.5%
7). Fragrance 0.5%
8). Extract of Example 6 1.0%
100%

<Example 98>
Chewing gum A chewing gum was prepared according to the following formulation.
1. Gum base 20.0%
2. Sugar 15.0%
3. Isomaltose 20.0%
4). Maltose 20.0%
5). Corn syrup 12.0%
6). Minamata 11.5%
7). Fragrance 0.5%
8). Extract of Example 7 1.0%
100%

<Example 99>
A troche was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Gum arabic 6.0%
2. Palatinose 30.0%
3. Multitose 20.0%
4). Isomaltose 22.0%
5). Gelatin 3.0%
6). Fragrance 0.2%
7). Extract of Example 1 1.0%
8). Purified water balance
100%

<Example 100>
A troche was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Gum arabic 6.0%
2. Palatinose 30.0%
3. Multitose 20.0%
4). Isomaltose 22.0%
5). Gelatin 3.0%
6). Fragrance 0.2%
7). Extract of Example 2 1.0%
8). Purified water balance
100%

<Example 101>
A troche was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Gum arabic 6.0%
2. Palatinose 30.0%
3. Multitose 20.0%
4). Isomaltose 22.0%
5). Gelatin 3.0%
6). Fragrance 0.2%
7). Extract of Example 3 1.0%
8). Purified water balance
100%

<Example 102>
A troche was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Gum arabic 6.0%
2. Palatinose 30.0%
3. Multitose 20.0%
4). Isomaltose 22.0%
5). Gelatin 3.0%
6). Fragrance 0.2%
7). Extract of Example 4 1.0%
8). Purified water balance
100%

<Example 103>
A troche was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Gum arabic 6.0%
2. Palatinose 30.0%
3. Multitose 20.0%
4). Isomaltose 22.0%
5). Gelatin 3.0%
6). Fragrance 0.2%
7). Extract of Example 5 1.0%
8). Purified water balance
100%

<Example 104>
A troche was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Gum arabic 6.0%
2. Palatinose 30.0%
3. Multitose 20.0%
4). Isomaltose 22.0%
5). Gelatin 3.0%
6). Fragrance 0.2%
7). Extract of Example 6 1.0%
8). Purified water balance
100%

<Example 105>
A troche was prepared according to the following composition. The total amount was 100% by mass with purified water.
1. Gum arabic 6.0%
2. Palatinose 30.0%
3. Multitose 20.0%
4). Isomaltose 22.0%
5). Gelatin 3.0%
6). Fragrance 0.2%
7). Extract of Example 7 1.0%
8). Purified water balance
100%

Claims (4)

  Dipterocarpus obtusifolius, Parkia religiosa, Eugenia javanica, Eugenia paniala, Eugenia siamensis wall, macro Leraphylla macro And an extract of at least one plant selected from the group consisting of Achras sapotal as an active ingredient.   A skin external preparation containing the collagenase inhibitor according to claim 1.   An oral composition containing the collagenase inhibitor according to claim 1.   A food containing the collagenase inhibitor according to claim 1.