JP2009235051A - Pimple improving agent and skin external preparation article - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new material for preventing and/or improving a pimple and an external preparation article for skin using it. <P>SOLUTION: A pimple improving agent has, as an effective component, an extract from a plant belonging to genus Astilbe such as Astibe thunbergii, preferably a combined material of the extract and polyphenols. The external preparation article for skin can be obtained by blending the pimple improving agent. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

The present invention relates to an acne-improving agent comprising an extract of a plant belonging to the genus Pleurotus as an active ingredient and an external skin product containing the same.

Acne, also known as acne, is an inflammatory disease of the skin and is diagnosed with acne vulgaris or folliculitis. There are still many unclear points about the pathogenesis of acne, for example, lipid-requiring skin resident bacteria (Propionibacterium acnes), Malassezia globosa, Malassezia rostrica (M. rostrica), etc. ) Shows that free fatty acids produced by degrading sebum are flammable, the cells activate the complement and show a hypersensitivity reaction, and the secreted substances due to the growth of the cells induce inflammation of the epidermis. It has been. When these factors stimulate inflammation-inducing proteins in the skin tissue, inflammation occurs, and the sebaceous glands become enlarged, red and swollen, and pus accumulates, resulting in acne symptoms.

For the treatment of acne, as a component of topical drugs, tetracycline antibacterial agents such as hexachlorophene and benzalkonium chloride, female hormones that inhibit sebum secretion, corticosteroids such as glucocorticoid and hydrocortisone, and other anti-inflammatory agents In addition, vitamin B2 that promotes skin metabolism, vitamin B6 that enhances skin resistance, vitamin C that prevents pigmentation, and the like are used as components of internal medicines. However, for example, long-term use of topical drugs containing steroidal components weakens the skin's resistance, making them susceptible to infection with bacteria, viruses, fungi, etc. However, although the vitamins showed a mild effect, they were not fully satisfactory.

In addition, as a natural product-derived component for the prevention and improvement of acne, loquat extract (Patent Document 1), guava leaf and Gymnema leaf extract (Patent Document 2), sugina extract (Patent Document 3), Odaka Ryo Koji extract (patent document 4), kiwi seed extract (patent document 5) and the like have been proposed, but few have practically sufficient effects, and materials that exhibit even more powerful effects are required. It was.

JP-A-10-265364 JP 2001-226274 A JP 2002-47190 A JP 2006-62992 A JP 2007-99751 A

In view of such circumstances, an object of the present invention is to develop a novel material for preventing and / or improving acne and to provide an external skin product using the same.

In order to solve the above-mentioned problems, the present inventors have intensively studied various materials having an action of suppressing acne, and as a result, plants belonging to the genus Pichia such as red pepper exhibit a very powerful acne improving effect, The present inventors have found that this can be effectively used for external skin products such as cosmetics, and have completed the present invention.

That is, the feature of the present invention resides in an acne ameliorating agent comprising an extract of a plant belonging to the genus Pleurotus as an active ingredient. In this invention, it is desirable that the plant belonging to the genus Pleurotus is red pepper, and it is desirable that the extract is a plant belonging to the genus Pleurotus using water and / or a hydrophilic organic solvent.

Another feature of the present invention is that the acne-improving agent further comprises polyphenols. In this invention, it is desirable that the polyphenols be one or more selected from the group consisting of proanthocyanidins, tannins, catechins, flavones, flavonols, isoflavones and glycosides thereof. In addition, the polyphenols are one or more extracts selected from the group consisting of grape seeds or pericarp, guava leaves, apple fruits or skins, pomegranate leaves, puer tea leaves, green tea leaves, akamegashi bark and cocoa beans. Preferably it is.

Yet another feature of the present invention resides in an external skin product comprising any of the above-mentioned acne-improving agents.

In the plant belonging to the genus Pleurotus such as red pepper according to the present invention, the extract, particularly the extract containing a hydrophilic component, has a remarkable effect in improving acne symptoms. This effect is synergistically enhanced by combining the above-mentioned extract of a plant belonging to the genus Pleurotus such as red and tricholoma and polyphenols. For this reason, according to the present invention, the above-mentioned extract of plants belonging to the genus Pleurotus such as red pepper, and a combination of this and a polyphenol is used as an active substance, and the acne improver is blended An acne preparation for improving acne is provided.

The present invention is described in detail below. First, the acne improving agent which is the first feature of the present invention contains an extract of a plant belonging to the genus Astilbe as an active ingredient. Plants belonging to the genus Pleurotus are classified into the family Uchinosidae, and there are various examples of those according to the present invention. As representative examples, Akashima (scientific name: Astilbe thunbergii (SIEB. Et ZUCC.) MIQ.) Can be mentioned. A red ginger is a perennial that grows naturally in the mountains of Japan, and its rhizome is called red hemp, and has been used as a substitute for urtices (such as Cimifuga simplex WORMSKJORD) for the purpose of lower fever and detoxification since ancient times. It has been. In the present invention, what is referred to as red hemp or red hemp is also included.

As an example of a plant belonging to the genus Tigetasashi, Astilbe chinensis, A. austrosinensis, A.M. thunbergii, A.M. thunbergii (SIEB. et ZUCC.) Miq. : Akashouma, A. thunbergii (SIEB. et ZUCC.) MIQ. var. congesta BOISS. (= A. Odontophylla MIQ.): Triashoma, A. polyandra, A.M. grandis, A.M. rivularis, A.M. japonica (MORR.et DECNE.) A. GRAY: Awamorisho, A. microphylla KNOLL: S. pylori, A. myriantha and the like. In the present invention, red pepper and triash are preferred raw materials, and red pepper is most desirable.

The part of the plant belonging to the genus Pleurotus such as red pepper used in the present invention is preferably roots and / or rhizomes, and its mode is obtained by appropriately applying processing such as drying, shredding or grinding to the roots and / or rhizomes. Extract obtained by extraction with a solvent, an extract obtained by removing the solvent from the extract, column chromatography or solvent using an adsorbent such as silica gel, magnesium silicate, ion exchange resin, activated alumina, cellulose, activated carbon Any purified product subjected to a purification treatment such as fractionation may be used, but the above-mentioned extract or a purified product thereof is desirable from the viewpoint of convenience and effects of uses described later.

In the extraction treatment, water, a hydrophilic organic solvent or a mixed solvent thereof is preferably used as the extraction solvent, and this extract is used as an active ingredient of the agent of the present invention. As hydrophilic organic solvents, lower monohydric alcohols such as methanol, ethanol, propanol and isopropanol, polyhydric alcohols such as propylene glycol, 1,3-butanediol and glycerin, acetone, methyl ethyl ketone, ether, petroleum ether, ethyl acetate and These hydrates and mixtures can be exemplified. In order to efficiently obtain an extract for achieving the desired effect of the present invention, it is desirable to use ethanol, acetone, ethyl acetate, and their hydrates as a solvent for extraction. The water content of the hydrated product is, for example, 1 to 99% by weight in the case of ethanol, more preferably 10 to 50% by weight, and 1 to 50% by weight in the case of acetone, more preferably 10 to 30% by weight. In the case of ethyl acetate, it is 80 to 99% by weight, more preferably 85 to 95% by weight. Outside these ranges, the desired effect of the present invention is reduced or the yield of the extract is reduced.

In order to easily and efficiently obtain the purified product according to the present invention, for example, extraction with water-containing ethanol or water-containing acetone is preferable, and the extract is further fractionated with ethyl acetate to collect the soluble fraction. . In the extraction treatment, an extraction solvent is added in an amount of about 1 to 100 times by weight with respect to the raw material, and the mixture is appropriately stirred at normal temperature or under pressure at room temperature or in a heated state for 10 minutes to several days. Subsequently, the insoluble matter is filtered or centrifuged to obtain an extract according to the present invention, and the solvent is removed from the extract by known means such as vacuum distillation, spray drying, freeze drying and the like. The extract which concerns on can be obtained. Further, a purified product can be obtained by subjecting this extract to known purification processes such as fractionation with an adsorbent, solvent fractionation, and combinations thereof.

It is known that the roots and rhizomes of plants belonging to the genus Tigetasas, such as red pepper, contain flavonoids such as bergenin, astilbine, and astilbic acid in addition to starch and tannin. It is said to show an effect. On the other hand, this invention discovered that the said extract and refined | purified substance of the plants of the genus Pleurotus such as red pepper significantly improve the acne symptom.

The acne-improving agent of the present invention comprises an extract of the plant belonging to the genus Acanthaceae obtained as described above as an active ingredient, but in order to further enhance the desired effect of the present invention, a polyphenol is used in combination. It is desirable. The polyphenols used in the acne-improving agent of the present invention may be known ones, and among them, plant polyphenols are easily available and simple. This includes hydrolyzable tannins, catechins, condensed tannins (such as proanthocyanidins), flavones, flavonols, isoflavones and the like. Examples of hydrolyzable tannins include gallotannins (pentotannins, gallic tannins, etc.), ellagitannins (pedencragin, terimagradin, casuarine, etc.), ellagitannins oligomers (agrimoniin, enotein B, etc.), and caffeine tannins (rosmarinic acid, lithospermic acid, etc.) it can. Catechin is epicatechin, epigallocatechin, epigallocatechin gallate, etc. Condensed tannin is a catechin condensate, such as properocyanidins such as propelargonidin, procyanidin, prodelphinidin and their acid degradation products (anthocyanidins) Can be mentioned. Examples of flavones include apigenin and luteolin, examples of flavonols include quercetin, quercitrin, isoquercitrin, rutin, kaempferol and the like, examples of isoflavones include daidzein, genistein, and isogenin, and glycosides thereof.

In the acne improving agent of the present invention, hydrolyzable tannin, catechin, proanthocyanidins, flavones, flavonols, isoflavones and glycosides thereof, more preferably hydrolyzable tannins, catechins and flavonols are used. It is desirable to use in combination with the above-mentioned processed product of the genus Pleurotus.

The polyphenols may be pure products that are chemically synthesized, but natural products containing them, more preferably plants as raw materials, subjected to treatments such as drying, crushing, extraction, concentration and distillation according to known methods. It is preferable to use the resulting extract or purified product. That is, it is not particularly limited as long as it is a plant containing the polyphenols, but desirably grape seeds or pericarp, guava leaves, apple immature fruits or skins, chuchu leaves, Pu'er tea leaves, green tea leaves, red mulberry bark, mulberry leaves , Using buckwheat whole grass, soybeans, French coastal pine, cacao beans, etc., using one or more as raw materials, extracting by adding a solvent to those appropriately processed by drying, shredding or grinding Treated extract, extract obtained by removing the solvent from the extract, column chromatography filled with an adsorbent such as silica gel, magnesium silicate, ion exchange resin, activated alumina, cellulose, activated carbon, etc. Any of these may be used. In order to express the desired effect of the present invention more strongly, an extract extracted with water and / or a hydrophilic organic solvent or a purified product thereof is desirable.

This extraction treatment is carried out using lower monohydric alcohols such as methanol, ethanol, propanol and isopropanol, polyhydric alcohols such as propylene glycol, 1,3-butanediol and glycerin, and hydrophilic organic materials such as acetone, methyl ethyl ketone and mixtures thereof. Using a solvent or a water-containing solvent thereof, add the extraction solvent in an equal weight or about 100 times by weight with respect to the raw material, and at normal pressure or under pressure, at room temperature or in a heated state for 10 minutes to several days with appropriate stirring. After the extraction treatment, the insoluble matter is removed by centrifugation or filtration to obtain an extract containing polyphenols. Further, the solvent is removed from the extract by means of vacuum distillation, freeze drying, spray drying or the like. An extract containing polyphenols can be prepared. The extract can be subjected to the purification treatment to obtain a purified product containing polyphenols at a high concentration. These commercially available products may be used in the present invention.

Desirable embodiments of the acne-improving agent of the present invention include an extract or purified product of a plant belonging to the genus Acanthaceae obtained as described above, for example, a dried product of red root and / or rhizome. It is. A more preferable embodiment is essential from the plant belonging to the genus Pleurotus genus, and contains a combination of polyphenols, and most preferably mainly uses an extract or a purified product of red rhizome. Combined with one or two or more extracts or purified products selected from the group consisting of grape seeds or pericarp, guava leaves, immature apple or skins, tochu leaves, pu-er tea leaves, green tea leaves, akamegasiwa bark and cacao beans It will be.

The ratio of both of the treated product of the genus Pleurotus plant and the treated product containing the polyphenols is difficult to define uniformly depending on the form of each treated product. Processed products containing polyphenols = 100/0 to 1/99 (weight ratio; the same unless otherwise specified), more preferably 100/0 to 50/50, most preferably 90/10 to 60 / 40.

The acne-improving agent of the present invention uses the treated product of the plant belonging to the genus Pleurotus or the treated product containing polyphenols, and if necessary, known excipients, binders, disintegrants, abundant agents. Mixing appropriate amounts of agents, diluents, etc., for example, sugars, sugar alcohols, starches, celluloses, dicalcium phosphate, mica, talc, purified water, ethanol, etc., to form solid, paste or liquid Can be processed. The content of the processed product of the genus Pleurotus in the acne-improving agent of the present invention is about 0.1 wt% to 100 wt%, more preferably about 10 wt% to about 80 wt%. If it is less than about 0.1% by weight, the desired effect may not be achieved in an external skin product using the acne-improving agent of the present invention.

In the external skin preparation of the present invention, the acne-improving agent may be used as it is as an external skin preparation. However, if necessary, a known additive used for an ordinary external skin preparation may be used in combination with a conventional method. It is desirable to prepare it as a composition. Here, the known additive may be any one that is used in pharmaceuticals, cosmetics, toiletry products, etc. and does not violate the gist of the present invention. For example, excipients, binders, disintegrants Various additives such as lubricants, wetting agents, fluidizing agents, preservatives, surfactants, stabilizers, diluents, solubilizers, bactericides, preservatives, colorants, and fragrances can be used.

Among the above-mentioned known additives, examples of excipients include cellulose and derivatives thereof, starch, modified starch, dextrin, resistant digestive dextrin, sugar alcohols such as lactose, mannitol, sorbitol, dicalcium phosphate, mica, talc, etc. Is mentioned.

Binders and disintegrators include cellulose derivatives such as crystalline cellulose, methylcellulose, ethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, hydroxypropylmethylcellulose acetate succinate, carmellose sodium, starch derived from wheat, rice, corn, potato, etc. Pregelatinized starch, partially pregelatinized starch, modified starch such as hydroxypropyl starch, dextrin, pullulan, polyvinylpyrrolidone, aminoalkyl methacrylate copolymer, methacrylic acid copolymer, polyvinyl acetal diethylaminoacetate, polyvinyl alcohol, gum arabic, agar, gelatin, white Examples include shellac, tragacanth, and macro goal.

As a lubricant, for example, starch derived from wheat, rice, corn, potato, stearic acid, calcium stearate, magnesium stearate, hydrous silicon dioxide, light anhydrous silicic acid, synthetic aluminum silicate, dried aluminum hydroxide gel, talc , Magnesium aluminate metasilicate, calcium hydrogen phosphate, anhydrous calcium hydrogen phosphate, sucrose fatty acid ester, waxes, hydrogenated vegetable oil, polyethylene glycol and the like.

Wetting agents, moisturizing agents and emollients include squalane, squalene, lecithin, lysolecithin, cholesterol, sphingolipid, serine, glutamine, sorbitol, mannitol, glycerin, pyrrolidone carboxylic acid, 1,3-butylene glycol, propylene glycol, dipropylene Glycol, lactic acid and its salt, hyaluronic acid, sodium hyaluronate, collagen, water-soluble collagen, hydrolyzed elastin, alginic acid and its salt, mucopolysaccharide, polyethylene glycol, polyaspartate, water-soluble chitin, water-soluble chitosan, glucosamine And its derivatives, N-acetyl-D-glucosamine, cholesteryl long-chain acyl glutamate, cholesteryl hydroxystearate, hydrogenated castor oil, 12-hydroxystearic acid Ricinoleic acid, stearic acid, rosin acids, lanolin, lanolin fatty acid cholesteryl ester, isopropyl myristate, cetyl palmitate, isononyl isononanoate, silicone oils (cyclomethicone, dimethicone, cyclomethicone, etc.), can be exemplified milk whey, or the like.

Examples of the fluidizing agent include fine silicon dioxide, hydrous silicon dioxide, light anhydrous silicic acid, dry aluminum hydroxide gel, synthetic aluminum silicate, magnesium silicate and the like.

Antioxidants include ascorbic acid, tocotrienol, dl-α-tocopherol, α-tocopherol, γ-tocopherol, δ-tocopherol, tocopherols such as tocopherol acetate, isopropyl citrate, disodium calcium ethylenediaminetetraacetate, dibutylhydroxytoluene Phytic acid, caffeic acid, catechin, gallic acid, propyl gallate, erythorbic acid and its sodium salt, dilauryl thiodipropionate, L-cysteine hydrochloride and the like.

Examples of preservatives and preservatives include benzoic acid, sorbic acid, paraoxybenzoic acid, methyl paraoxybenzoate, propyl paraoxybenzoate, isopropyl paraoxybenzoate, propionic acid, sodium sulfite, chlorobutanol and the like.

Examples of surfactants include soy lecithin, egg yolk lecithin, lysolecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, glycerophospholipids such as phosphatidylserine, sucrose fatty acid esters, glycerin fatty acid esters, diglycerin fatty acid esters such as diglycerin fatty acid esters Sorbitan fatty acid esters such as esters, sorbitan monostearate, sorbitan sesquioleate, polyoxyethylene higher alcohol ethers, polyoxypropylene higher alcohol ethers, polyoxyethylene fatty acid esters, polyoxypropylene fatty acid esters, polysorbate 80, polyoxyethylene sorbitan Nonionic surfactants such as fatty acid esters, polyoxyethylene hydrogenated castor oil, benzil chloride Cationic surfactants such as conium, stearyltrimethylammonium chloride, dicetyldimethylammonium chloride, and behenyltrimethylammonium chloride; amphoteric surface activities such as 2-cocoyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and betaine amidoacetate Agent, higher alcohol sulfate, higher alcohol ether sulfate, long chain fatty acid alkali metal salt, long chain fatty acid alkaline earth metal salt, long chain fatty acid basic amino acid salt, N-long chain acyl amino acid, N-long chain acyl amino acid There are anionic surfactants such as salts.

Examples of the stabilizer include paraoxybenzoates such as methylparaben and propylparaben, alcohols such as chlorobutanol, benzyl alcohol, and phenylethyl alcohol, benzalkonium chloride, acetic anhydride, sorbic acid, and the like.

Diluent, solubilizer, solubilizer, purified water, ethanol, lauryl sulfate triethanolamine, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, glycerin, olive oil, castor oil, silicone oil, liquid paraffin, cyclodextrin, etc. is there.

Examples of isotonic agents include sodium chloride, potassium chloride, glycerin, boric acid and the like.

Examples of pH adjusters include lactic acid, succinic acid, fumaric acid, citric acid, malic acid, tartaric acid, gluconic acid, and sodium or potassium salts thereof, glucono delta lactone, adipic acid, sodium acetate, arginine, triethanolamine. Sodium hydroxide, potassium hydroxide, phosphoric acid, sodium dihydrogen phosphate, tripotassium hydrogen phosphate and the like.

Examples of the ultraviolet absorber include paraaminobenzoic acid derivatives such as paraaminobenzoic acid and octylparadimethylaminobenzoate, benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone and dihydroxydimethoxybenzophenone, ethyl paramethoxycinnamate, and octyl paramethoxycinnamate. Methoxycinnamic acid derivatives such as octyl salicylate, salicylic acid derivatives such as homomenthyl salicylate, α-dehydroamino acid derivatives such as N-benzoyl-O-methyl-α-dehydrotyrosine-2-ethylhexyl ester, 4- (3,4-dimethoxy) Benzalhydantoin derivatives such as phenyl) methylene-2,5-dioxo-1-imidazolidinepropionic acid 2-ethylhexyl ester, urocanic acid, ethyl urocanate, 4-ter-butyl -4'-methoxydibenzoylmethane, 2- (2'-hydroxy-5'-methylphenyl) benzotriazole, and the like.

Examples of the disinfectant include hinokitiol, triclosan, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zinc pyrithione and the like.

Examples of colorants include zinc oxide, titanium oxide, iron oxide, silica, talc, mica, copper chlorophyll, water-soluble anato, β-carotene, riboflavin and its butyrate, gardenia yellow, blue No. 1, red No. 202, edible Examples include Red No. 2, No. 105, Edible Yellow No. 4, Edible Green No. 3, Edible Blue No. 2, and the like.

In addition, various fragrances and plant essences can be used as necessary, and as fats and oils, vegetable oils such as avocado oil, olive oil and jojoba oil, fatty acids such as oleic acid and isostearic acid, petrolatum, lanolin, ceresin, microcrystalline wax, Carnauba wax, candelilla wax, coconut oil fatty acid, lauric acid, hardened beef tallow fatty acid and other fatty acids, cetyl 2-ethylhexanoate, isopropyl myristate, 2-octyldodecyl myristate, neopentyl glycol di-2-ethylhexanoate, Ester oil such as glycerol tri-2-ethylhexanoate, oleic acid-2-octyldodecyl, glycerol triisostearate, 2-ethylhexanoic acid diglyceride, ester oil such as long chain acyl glutamic acid octyldodecyl ester, Siloxane, methyl hydrogen polysiloxane, methylphenyl polysiloxane, silicone oils such as octamethylcyclotetrasiloxane, liquid paraffin, can be used squalene, etc. in appropriate liquid hydrocarbon oils squalane. In addition, this invention is not limited at all by these each illustration.

The form of the external skin product of the present invention is not particularly limited, and is generally applied to the skin, hair and scalp, and is a dosage form such as a lotion, emulsion, gel, cream, ointment, etc. For example, lotion, emulsion, cream, foundation, pack, essence, lipstick, face wash, shampoo, rinse, hair tonic, hair treatment and the like can be mentioned. In addition, quasi-drugs such as ointments, poultices, bath preparations, cleaning agents and aerosols may be included.

In order to produce the skin external product of the present invention, the above-mentioned known additives may be appropriately selected, and a predetermined amount of the acne-improving agent of the present invention may be added thereto, followed by processing by an ordinary production method. Here, the compounding amount of the acne-improving agent of the present invention is about 0.01% to about 90% by weight, more desirably about 0.1% to about 70% by weight as the extract of the plant belonging to the genus Acanthus contained in the agent. % By weight. If the amount is less than about 0.01% by weight, the external skin product of the present invention may not exhibit the desired effect, and if it exceeds about 90% by weight, it may be difficult to process a normal dosage form as an external skin product. In order to prevent and / or ameliorate acne symptoms, the external skin product of the present invention can be appropriately used by applying or contacting the skin or scalp.

Next, although an Example is given and this invention is demonstrated in detail, this invention is not limited at all by this. In each example, all the percentages, parts and ratios are based on weight.

Production Example 1
1 kg of dried rhizome of Astilbe thumbergii (SIEB. EtZUCC.) MIQ. Crushed to 3-5 mm square size was charged into a stainless steel extraction kettle, and 8 L of water-containing ethanol with a moisture content of 48 wt% was added. The mixture was extracted at 70 ° C. for 4 hours with stirring. Thereafter, the insoluble residue was removed by filtration, and the extract was collected. The extract was subjected to vacuum concentration treatment to remove the solvent, and 74 g of a reddish brown extract (referred to as sample A-1) was obtained.

Production Example 2
1 Kg of red pepper rhizome used in Production Example 1 was placed in a stainless steel extraction kettle, 10 L of water-containing acetone having a water content of 25% by weight was added, and the mixture was extracted for 3 hours under reflux. divided. The residue was again added with 5 L of water-containing acetone and treated in the same manner to obtain an extract. Both extracts were combined and the solvent was distilled off under reduced pressure to obtain 86 g of a reddish brown extract (referred to as sample A-2).

Production Example 3
50 g of red pepper rhizome extract (sample A-2) obtained in Production Example 2 was suspended in 1 L of ion-exchanged water, 250 mL of ethyl acetate was added to the suspension and stirred, and then the ethyl acetate layer was collected. Solvent fractionation in which the same amount of ethyl acetate was added to the layer and treated in the same manner was repeated three times. The ethyl acetate layers were combined, the solvent was distilled off under reduced pressure, and the ethyl acetate-soluble fraction (sample A- 3) 23 g was obtained.

Production Example 4
The rhizomes of Astilbe odontophylla MIQ. Were sun-dried and dried, and 1 Kg of this crushed piece was treated in the same manner as in Production Example 1 to obtain 80 g of a reddish brown extract (referred to as sample A-4).

Comparative production example 1
A dried leaf obtained by sunshine-drying guava leaves and crushed to a size of about 5 mm square or less was charged into a stainless steel extraction kettle, and 10 L of hydrous ethanol with a moisture content of 47% by weight was added, followed by extraction treatment under reflux for 5 hours. Thereafter, the residue was filtered off and the extract was collected. The solvent was distilled off from the extract under reduced pressure to obtain 330 g of a brown guava leaf-derived tannin-containing extract (referred to as sample C-1).

Comparative production example 2
The dried grape seeds were crushed to a size of about 2 mm square or less, 1 kg of this was charged into a stainless steel extraction kettle, 10 L of water-containing ethanol with a water content of 25% by weight was added, and the mixture was extracted for 4 hours under reflux. The residue was collected by filtration, and the extract was collected. The solvent was distilled off from the extract under reduced pressure to obtain 257 g of a proanthocyanidin-containing extract derived from brown grape seed (referred to as sample C-2).

Comparative production example 3
The dried green tea leaves are crushed to a size of about 3 mm square or less, 1 kg of this is charged into a stainless steel extraction kettle, 10 L of water-containing ethanol adjusted to a water content of 30% by weight is added and subjected to extraction treatment under reflux for 5 hours. The extract was collected by filtration, and the solvent was distilled off from the extract under reduced pressure to obtain 270 g of a catechin-containing extract (referred to as sample C-3) derived from brown green tea leaves.

Test example 20-41 years old, 80 men and women who are suffering from acne (10 people per group), after thoroughly washing their face with cosmetic soap, skin external prototypes (prototype Nos. 1-4 and comparisons) Application prototype Nos. 5 to 8) were applied 2-3 times a day for 4 weeks and observed. Here, the skin external prototype is a skin lotion type, and the formulation is based on ethanol: 10.0%, sorbitol (70%): 3.0%, glycerin: 4.0%, polyoxylene (40 mol) ) Addition hardened castor oil: 0.5%, citric acid: 0.2%, and ion-exchanged water: remaining amount. Sample A-1, Sample A-2, Sample A-3, Sample A-4 were added to this basic composition. Samples C-1, C-2, or C-3 were prepared according to conventional methods, with each required amount adjusted and blended with the amount of ion-exchanged water. Regarding the evaluation of these prototypes, the skin condition was observed before and after use, and the acne improvement degree was evaluated in three stages based on the criteria of (a) improved, (b) no change, (c) deteriorated. The acne improvement effect is: ◎: (a) is 75% or more, ○: (a) is 74% to 50%, Δ: (a) is 49% to 25%, and X: (a) is 24% or less. Judged. The results are shown in Table 1.

As a result, when the sample concerning this invention was mix | blended, the remarkable effect was recognized in the improvement of an acne (prototype No. 1-4). It should be noted that the prototype No. with an acne improvement effect was ◎. The evaluation numerical values of (a) of 2 to 4 are the prototype Nos. 2 is 80%. 3 and no. 4 was 90% each. On the other hand, this effect was not recognized when only a basic compounding prescription (prototype No. 8) and a comparative sample were blended (prototype Nos. 5 to 7).

Prototype examples 1-7
Various types of external skin products were made using the following formulation (all values are% by weight).
(1) Lotion (a) Sorbit 2
(B) Glycerin 4
(C) Polyethylene glycol 1000 2
(D) Ethanol 10
(E) Sample A-1 1
(F) Preservative (Methylparaben) Appropriate amount (g) Purified water The remaining amount (a) to (f) is added to (g) heated to 80 ° C., stirred and dissolved, then cooled to room temperature and filled into a container did. This lotion can be used as an external skin preparation for improving acne.

(2) Latex (a) Squalane 4
(B) Vaseline 1
(C) Cetyl alcohol 0.5
(D) Sorbitan monostearate 1.5
(E) Polyoxyethylene (20) sorbitan monooleate 3
(F) Glycerin 5
(G) Sample A-2 5
(H) Sample C-3 2
(I) Purified water The remaining amounts (a) to (d) were heated and dissolved at 80 ° C. to obtain an oil phase component, and (e) to (i) were heated and dissolved at 80 ° C. to obtain an aqueous phase component. At the same temperature, the oil phase component was added to the aqueous phase component with stirring, and the mixture was uniformly emulsified with a homogenizer, cooled to room temperature, degassed, and filled into a container. This emulsion can be used as an external skin preparation for preventing and / or improving acne.

(3) Cream (a) Squalane 20
(B) Beeswax 5
(C) Jojoba oil 5
(D) Sorbitan monostearate 1
(E) Glycerin sesquioleate 3
(F) Polyoxyethylene (20) sorbitan monostearate 3
(G) Glycerin 5
(H) Sample A-4 10
(I) Sample C-1 5
(J) Purified water The remaining amounts (a) to (e) were heated and dissolved at 80 ° C. to obtain an oil phase component, and (f) to (j) were heated and dissolved at 80 ° C. to obtain an aqueous phase component. At the same temperature, the oil phase component was added to the aqueous phase component with stirring, and the mixture was uniformly emulsified with a homogenizer, cooled to room temperature, degassed, and filled into a container. This cream can be used as an external skin product for preventing and / or improving acne.

(4) Body soap (a) Potassium laurate 13
(B) Potassium myristate 5
(C) Propylene glycol 7
(D) Sample A-2 10
(E) Hibiscus flower extract 3
(F) pH adjuster (citric acid) appropriate amount (g) preservative (methyl paraben) appropriate amount (h) purified water The remaining amount (a) and (b) were dissolved in advance by heating at 80 ° C. (c) to (h) The mixture was added to the solution with stirring and mixed uniformly with a homogenizer, then cooled to room temperature, degassed and filled into a container. This body soap can be used as an external skin product for preventing or improving acne.

(5) Shampoo (a) Lauric acid diethanolamide 2
(B) Lauryl sulfate triethanolamine 5
(C) Polyoxyethylene lauryl ether sodium sulfate 12
(D) 1,3-butylene glycol 4
(E) Edetate disodium 0.1
(F) Sample A-3 1
(G) Preservative and perfume appropriate amount (h) Purified water The remaining amount (b) to (h) is heated and dissolved to 70 ° C., (a) is added, emulsified with a homomixer, cooled and deaerated. Filled into a container.

(6) Hair tonic (a) Ethyl oleate 1
(B) Ethanol 45
(C) Polyoxyethylene (40) hydrogenated castor oil 2
(D) Sample A-1 15
(E) Sample C-2 5
(F) Purified water The remaining amount (c) to (f) was dissolved by heating to 60 ° C., the mixture of (a) and (b) heated to the same temperature was added, solubilized by a homomixer, cooled, Degassed and filled into containers.

(7) Powder bath agent (a) Sodium bicarbonate 50
(B) Anhydrous sodium sulfate 35
(C) Borax 3
(D) Sample A-3 7
(E) Sample C-3 5
(F) Chamomile extraction powder 4
(G) Coloring agent and fragrance Each appropriate amount (a) to (g) was mixed with a powder mixer and filled into a container. This powder bath agent can be used at the time of bathing to improve acne throughout the body.

(8) Ointment (a) Bleached beeswax 5
(B) Sorbitan sesquiole art 3
(C) White petrolatum 60
(D) Sample A-4 10
(E) Sample C-2 8
(F) Purified water The remaining amounts (a) to (e) were mixed at 60 ° C., (f) heated to the same temperature was added and kneaded, and then cooled, degassed and filled into a container. This ointment can be applied to the affected area as needed as an external skin preparation for improving acne symptoms.

Extracts of plants belonging to the genus Pleurotus, such as red ginger, and combinations of these extracts and polyphenols have the effect of significantly improving acne symptoms by applying them to the skin. It can be used as an external skin product for prevention and / or improvement.

Claims (7)

An acne-improving agent comprising an extract of a plant belonging to the genus Pleurotus as an active ingredient. The acne-improving agent according to claim 1, wherein the plant belonging to the genus Pleurotus is red pepper. The acne-improving agent according to claim 1 or 2, wherein the extract is an extract of a plant belonging to the genus Pleurotus using water and / or a hydrophilic organic solvent. The acne improving agent according to any one of claims 1 to 3, further comprising polyphenols. The acne-improving agent according to claim 4, wherein the polyphenol is one or more selected from the group consisting of proanthocyanidins, tannins, catechins, flavones, flavonols, isoflavones and glycosides thereof. 5. The polyphenol is one or more extracts selected from the group consisting of grape seeds or peels, guava leaves, apple fruits or peels, chuchu leaves, pu-erh tea leaves, green tea leaves, red mulberry bark and cocoa beans. Or the acne improving agent of 5. An external skin product containing the acne-improving agent according to any one of claims 1 to 6.