JP2009242273A - Oral composition capable of lowering serum ldl cholesterol level - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an oral composition capable of lowering serum LDL cholesterol level, and to provide the oral composition which is capable of lowering the serum LDL cholesterol level without affecting serum HDL cholesterol level and is prepared using an orally ingestible material which is harmless in long-term use. <P>SOLUTION: An extract from willow tree bark and/or bud is compounded with the oral composition. Particularly, the oral composition preferably comprises a bark extract of Salix sp. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to an oral composition characterized by reducing LDL cholesterol level in serum containing willow bark extract and / or willow bud extract.

  It is known that if the serum cholesterol level, particularly the state of high LDL cholesterol level, continues, the risk of alteration of the vascular tissue increases. If this condition is left untreated, dyslipidemia develops and ultimately causes heart disease and cerebrovascular disease that account for about 30% of Japanese deaths, reducing serum LDL cholesterol. It is important to keep it low. However, due to irregular eating habits and excessive intake of animal lipids due to disordered dietary habits, the number of people who develop dyslipidemia increases year by year as serum LDL cholesterol levels increase. is doing.

    Since the LDL cholesterol level in serum is greatly affected by the meal content, a method of improving the meal content and lowering the serum LDL cholesterol level is effective and most preferred. However, it is actually difficult to improve and continuously execute the meal content, and a method for lowering the LDL cholesterol level in serum without changing the daily meal content is desired. Although taking medicines is highly effective and easy to implement, there are many people who take medicines for long periods of time depending on their efficacy, so there is a risk of side effects such as rhabdomyolysis and liver dysfunction. This is not preferable because it increases the cost increase.

Therefore, development of functional foods containing food-derived materials as active ingredients has been promoted as a method that is easy to implement and that does not cause safety problems even when carried out for a long period of time. For example, Patent Literature 1 discloses a cholesterol-lowering agent containing an extract of edible edible active ingredient as an active ingredient, and Patent Literature 2 discloses Lactobacillus species (Lactobacillus).
sp. Serum cholesterol-lowering composition comprising an isolated strain of)) as an active ingredient, Patent Document 3 proposes a serum cholesterol-lowering agent containing a peptide contained in egg white as an active ingredient. There is nothing to get.
JP 2007-210990 A JP 2007-135596 A JP 2007-126369 A

  An object of the present invention is to provide an oral composition having a lowering effect on serum LDL cholesterol level.

  In order to solve the above-mentioned problems, the present inventors have found that willow bark extract and / or willow bud extract have an excellent effect of lowering LDL cholesterol level in serum, and have completed the present invention.

That is, the present invention provides the following composition.
Item 1. An oral composition characterized by lowering LDL cholesterol level in serum containing willow bark extract and / or willow bud extract.
Item 2. The oral composition according to claim 1, which is a food with a label “helping keep cholesterol normal”.

  According to the present invention, an oral composition having a lowering effect on serum LDL cholesterol level can be provided.

  Hereinafter, the present invention will be described in more detail.

The willows that can be used in the present invention are plants belonging to the Populus genus or Salix family of the Salicaceae family. Examples of plants belonging to the Populus genus, Mallotus Ha Koyanagi (aka marine, Populus alba; P.Alba), Canada poplar, American Black Mountain break (aka Hiro ha Koyanagi), populus euphratica, (P. euphratica), Oba Mountain leveling (P.Tomentosa) , Chilemendro (P.koreana), Dronoki (P.maximowiczii), European black willow (P.nigra), Atlantic willow ( aka Italian porcupine; P.nigra var. Italica), Porcupine ( aka poplar; poplar; P. sieboldii) , Balsam poplar (P. tecamahaca), long-tailed porcupine, P. davidiana, P. tremuloides, P. euramericana and the like. Examples of plants belonging to the genus Salix include: S. alba, S. alopochroa, Yusura willow, Weeping willow ( also known as S. babylonica), Siberian willow ( also known as S. bakko) , Red willow ( aka S. chaeagnos), S. chrysochoma, S. daphnoides, S. elaeagnos Scopoli, S. futura, S. futura, aka Sana. gilgiana), cat willow (S. alba) (S. gracilistyla), black willow (S. gracilistyla var. melanostachys), saus (S. humboldtiana), Incoryana nagi (S. integral), white willow (S. japonica), white willow (S. jessoens), Kinuyanagi (S.kinuyanagi), Koryanagi (S.koriyanagi), Ezo willow (S.rorida), Frisode willow ( S. leucopithecia), Unryu willow (S. matsudana f. Tortuosa), Takane willow ( also known as Rengay willow), S.ohshidare, S. nummularia ssp. Pauciflora, Ezo. susu), S. purpurea, Kou Hiryu, Miyama willow ( aka S. reinii), Komai willow (S. rupifraga), Onoe willow (aka Karafuto willow; S. sachalinensis), S. serissaefolia (S. serissaefolia), Shirai willow , Salix sp, S. subfragilis, Japanese willow (also known as Japanese willow), Japanese willow, Japanese willow ( also known as S. vulpina), S. yezoalpina, etc. The extraction sites of willow are bark and barley. / Or buds (especially new shoots) are used, but their leaves, flowers, fruits, branches, trunks, etc. are partly mixed Good. Preferred willow is Western willow, among others Salix daphnoides, Salix sp, Salix purpurea, Salix fragilix, a Salix alba.

  In the present invention, the willow bark extract or willow bud extract is preferably extracted after processing the willow bark and buds into a shape suitable for extraction, such as shredding, drying, and grinding, as necessary. . Usually, the treated willow extraction site is extracted by using an extraction solvent by allowing it to stand, shake, irradiate with ultrasonic waves, heat, pressurize, etc. or a combination thereof. Preferably, the willow extraction site is immersed in an extraction solvent and shaken or stirred.

As the extraction solvent, water, an organic solvent or the like is usually used alone or in combination of two or more. Organic solvents are usually lower alcohols such as ethanol, propanol, isopropanol and butanol; polyhydric alcohols such as polyethylene glycol, propylene glycol, 1,3-butylene glycol and dipropylene glycol; esters such as ethyl acetate and butyl acetate. Ketones such as acetone and methyl ethyl ketone; Supercritical fluid such as CO ₂ can be used. A preferred extraction solvent is water or ethanol, which can be used alone or in combination. A more preferred extraction solvent is water.

  The extraction temperature is usually 3 to the boiling point of the solvent. The extraction time varies depending on the type of extraction solvent, the extraction temperature, the form of the willow extraction site, etc., but is usually 1 hour to 7 days, preferably 2 hours to 3 days. Moreover, it can also pressurize as needed.

  The extract can be used as it is as the willow bark extract and / or willow bud extract in the present invention, but the concentrated, dried, freeze-dried extract can be dissolved in water, an organic solvent or the like, or extracted. Performs purification processes such as decolorization, deodorization, and desalting as long as the effects of the product are not impaired, and liquid / liquid distribution. What was obtained by performing the fractionation process by column chromatography etc. can also be used. Moreover, a willow bark extract and / or a willow bud extract can be used by being encapsulated in a carrier such as a liposome or a microcapsule.

  The content of the willow bark extract and / or willow bud extract in the oral composition for lowering the LDL cholesterol level in the serum of the present invention is 0.0001 to 50% by weight, preferably 0.01 to 30% by weight, More preferably, it is 0.5 to 10% by weight.

  The oral composition of the present invention is in a form suitable for oral intake depending on the purpose of use, for example, a solid agent such as a liquid, a drink, a tablet, a granule, a fine granule, a powder, or the liquid or solid In addition to the capsules, oral sprays, and troches, various forms commonly used in foods can be used.

  Furthermore, as a solid agent such as a tablet, a tablet with a normal tablet skin, for example, a sugar-coated tablet, a gelatin-encapsulated tablet, a film-coated tablet, a double tablet, or a multilayer tablet can be used as necessary. The liquid preparation may be an aqueous or oily suspension, liquid, syrup, or exylylline, and can be prepared according to a conventional method using normal carriers, additives and the like.

  Preferable preparation forms are tablets, troches, granules, capsules, drinks, and more preferable preparation forms are tablets, granules or drinks.

  The oral composition of the present invention can contain foods and additives acceptable as pharmaceuticals and foods. For example, in addition to other nutritional components such as carbohydrates (sugars, carbohydrates, etc.), lipids, proteins, minerals, vitamins, dietary fiber, etc., ingredients necessary to impart food form and function (for example, Flavor ingredients, ingredients, bacteriostatic ingredients, pigment ingredients, various seasoning ingredients, etc.) and additives used in normal formulation (excipients such as palatinose, maltitol, lactose, saccharin, stevia, etc.) Sweeteners, magnesium stearate, lubricants such as sucrose fatty acid esters, acidulants such as citric acid, flavoring agents such as zinc chloride and powdered tea, flavoring agents), animal and plant extracts, and various medicinal ingredients. .

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not limited to the following Example. In addition, the compounding quantity in each example shows weight%, unless there is a prescription | regulation.

<Test example: Drinking test>

Test method The test was conducted on 16 healthy subjects (26-45 years old, mean age 34.2 years old; 7 men, 9 women). In the drinking test, a drinking period of 2 weeks and a washout period of 2 weeks were set, and there were no dietary restrictions or other restrictions during the drinking period and the washout period. The willow bark extract as the test substance was a western willow bark extract (powder). During the drinking period, subjects drank 800 mg per day of the willow bark powder extract encapsulated daily. Blood sampling was performed at the start and end of the drinking period and on the fasting time at the end of the washout period, and the total serum cholesterol level, HDL cholesterol level, and LDL cholesterol level were measured. For statistical analysis of the measurement results, ANOVA was performed using the week of the test as a factor, and when the F value was significant, Bonferroni analysis was performed as a post hoc test, and a significant difference test was performed at each week. The test result is indicated by “**” when significant at a risk rate of 1% or less, “*” when significant at a risk rate of 5% or less, and “−” otherwise. The measurement results are shown in Table 1.

Test results Serum LDL cholesterol levels decreased significantly after 2 weeks of consumption of the willow bark extract, and increased significantly at the end of the subsequent washout period. I'm back. On the other hand, no change was observed in the HDL cholesterol level in the serum, and the total cholesterol level in the serum showed the same tendency as the LDL cholesterol level. From the above, it has been found that drinking of a willow bark extract decreases the LDL cholesterol level without affecting the serum HDL cholesterol level.

  Below, the prescription example which concerns on this invention is described.

Example 1: Powdered food
Ingredient Weight%
Western willow bark extract 20.0%
Fructose 30.0%
Dextrin 42.4%
Peppermint flavor 3.0%
Ascorbic acid 2.5%
Sucralose 0.1%
Lemon flavor 2.0%
Total 100.0%

Example 2: Tablet
Ingredient Weight%
Galactose 38.0%
Western willow bud extract 15.0%
Crystalline cellulose 21.94%
Erythritol 10.0%
Sucralose 0.06%
Citric acid 5.0%
Minato 4.0%
Menthol 1.0%
Sucrose fatty acid ester 5.0%
Total 100.0%

Example 3
Ingredient Weight%
Reduced maltose starch syrup 52.0%
Lactose 10.0%
Western willow bark extract 5.0%
Bamboo leaf water extract 5.0%
Citric acid 7.0%
Peppermint flavor 1.5%
Spearmint flavor 1.0%
Peach flavor 2.5%
Purified water 16.0%
Total 100.0%

Example 4: Granular food
Ingredient Weight%
Western willow bark / bud extract 10.0%
Dokudami water extract 5.0%
Guava water extract 5.0%
Loquat water extract 5.0%
Dextrin 49.8%
Glucose 20.0%
Aspartame 0.2%
Apple flavor 5.0%
Total 100.0%

Example 5: Chewable tablets
Ingredient Weight%
Western willow bark extract 20.0%
Glucose 30.0%
Aspartame 0.15%
Erythritol 20.0%
Crystalline cellulose 22.85%
Sucrose fatty acid ester 4.0%
Spearmint flavor 3.0%
Total 100.0%

Example 6: Powdered tea
Ingredient Weight%
Western willow bark extract 30.0%
Pearl barley water extract 10.0%
Sencha water extract 5.0%
Coffee tea water extract 3.0%
Dextrin 18.9%
Glucose 20.0%
Sucralose 0.1%
Milk powder 10.0%
Ginger flavor 3.0%
Total 100.0%

Example 7: Gummy candy
Ingredient Weight%
Western willow bark extract 10.0%
Sucrose 55.0%
Glucose 10.0%
Citric acid 1.2%
Gelatin 8.0%
l-Menthol 0.1%
Ginger flavor 1.2%
Purified water 14.5%
Total 100.0%

Example 8: Capsule
Ingredient Weight%
Western willow bark extract 65.0%
Crystalline cellulose 35.0%
Total 100.0%

Claims (2)

An oral composition characterized by lowering LDL cholesterol level in serum containing willow bark extract and / or willow bud extract. The oral composition according to claim 1, which is a food with a label “helping keep cholesterol normal”.