JP2009011555A - Non-invasive biological information measuring device - Google Patents

Abstract

In a non-invasive living body information measuring apparatus for detecting a photoacoustic wave signal from a living body including a feature amount of living body information by entering light on the surface of the living body without increasing the size of the apparatus. A noninvasive living body information measuring device for detecting a mounting error is provided.
A non-invasive living body information measuring apparatus for detecting a photoacoustic wave signal from within the living body including a feature amount of living body information from the surface of the living body by making light incident on the surface of the living body, wherein the photoacoustic wave The first measurement position and the second measurement position are detected from the detection signal of the signal, and the distance between the first and second measurement positions is measured, and the distance is equal to or less than the compression threshold value A or the pulling threshold value B. More specifically, it includes a mounting confirmation unit 207 that outputs an error signal when the time-out threshold value C is equal to or higher than a timeout threshold C, and an error display unit 208 that notifies the error signal output by the mounting confirmation unit, and can be mounted without increasing the size of the apparatus. It is possible to provide a noninvasive living body information measuring apparatus that detects an error.
[Selection] Figure 2

Description

  The present invention relates to a non-invasive living body information measuring apparatus capable of measuring living body information without invading the living body, and more specifically, based on a photoacoustic wave signal from within the living body, an error in attaching the measuring apparatus to the living body. The present invention relates to a noninvasive living body information measuring apparatus capable of detection.

  The number of patients with diabetes, a typical lifestyle-related disease, is increasing worldwide. Diabetic patients require routine glycemic control to reduce complications from diabetes and improve the quality of life of patients. Therefore, patients must measure blood glucose regularly every day under the guidance of a doctor.

  As a typical method for measuring a blood glucose level, there is an invasive blood glucose measuring device that measures blood glucose level by collecting blood by inserting a patient's finger. The invasive blood glucose measurement device is troublesome and painful when blood is collected by puncturing a finger, and there is a risk of infection, etc., so there is no need to collect blood, and blood glucose measurement is not required. A device has already been proposed.

  As an example of this non-invasive blood glucose measurement device, a “biological measurement system” using a photoacoustic effect has been proposed (for example, Patent Document 1).

  A “biological measurement system” using a photoacoustic effect irradiates a part of a living body, such as a fingertip, from the biological measurement system with light having a wavelength absorbed by glucose. The light is focused on a relatively small focal area. In general, the collected light is absorbed by glucose and converted into kinetic energy in the tissue in the region adjacent to the focal region.

  The kinetic energy converted in the tissue increases the temperature and pressure of the absorbing tissue region and generates sound waves. This sound wave is hereinafter referred to as “photoacoustic wave signal”. The photoacoustic wave signal is emitted from the absorbing tissue region and detected by an acoustic sensor included in the biological measurement system. The acoustic sensor is mounted in contact with the living body surface. The intensity of the photoacoustic wave signal is a function of the amount of glucose in the absorbing tissue region, and the intensity measured by the sensor is used to examine the blood glucose level.

In addition, as a method of detecting a mounting failure of the photoacoustic sample cell using the photoacoustic effect, the photoacoustic cell is closely attached to the measurement object by providing a double sealing portion on the photoacoustic cell, and further, between the sealing portions. There has already been proposed a method for detecting an attachment error of a photoacoustic cell when suction is performed and the pressure does not drop to a predetermined pressure after suction for a certain time (for example, Patent Document 2).
Special table 2001-526557 gazette Japanese Patent Laid-Open No. 6-249837

  However, in the technique described in Patent Document 1, it is necessary to attach the acoustic sensor so as to be in contact with the living body surface. Therefore, a normal photoacoustic wave signal can be obtained depending on the contact state between the acoustic sensor and the living body surface. The blood glucose level is estimated based on the intensity of the erroneous photoacoustic wave signal. Therefore, there is a problem that there is a risk that the patient may administer insulin based on an incorrect blood glucose level.

  In addition, in order to obtain a normal photoacoustic wave signal, the technique for detecting a mounting error of the photoacoustic sensor (photoacoustic sample cell) described in Patent Document 2 described above is used for a pressure detector, vacuum suction, and sample airtightness. However, when these non-invasive blood glucose measuring devices are provided, the photoacoustic sensor is increased in size.

  SUMMARY OF THE INVENTION An object of the present invention is to solve the conventional problems, and to provide a noninvasive living body information measuring apparatus capable of detecting an acoustic sensor mounting error without increasing the size of the apparatus.

  In order to solve the conventional problem, a non-invasive living body information measuring apparatus according to claim 1 of the present invention is a photoacoustic wave from the living body that includes a feature amount of living body information by irradiating light on the surface of the living body. In a non-invasive living body information measuring apparatus for detecting a signal from the surface of the living body, at least one light source, control means for controlling the lighting timing of the light source and outputting an activation signal, and based on the activation signal, Photoacoustic detection means for detecting a photoacoustic wave signal from the living body by irradiation light and generating a detection signal; and feature quantity estimation means for estimating a feature quantity of biological information from the detection signal generated by the photoacoustic detection means A feature amount display means for displaying the feature amount of the biological information estimated by the feature amount estimation means, and a distance between the surface of the living body and a blood vessel in the living body based on the detection signal generated by the photoacoustic detection means. Measure An attachment confirmation means for confirming whether or not the noninvasive living body information measuring device is correctly attached to the living body according to the distance, and an error display means for notifying a user of an error signal output from the attachment confirmation means. It is provided with the feature.

  A noninvasive living body information measuring apparatus according to claim 2 of the present invention is the noninvasive living body information measuring apparatus according to claim 1, wherein the mounting confirmation means uses the first measurement position and the second from the detection signal. And measuring the distance between the first and second measurement positions, and determining whether or not the distance is a wearing state in which the living body is compressed by the noninvasive living body information measuring device Is a threshold value for compression A or less, a threshold value for pulling B that is a criterion for determining whether or not the living body is pulled by the noninvasive living body information measuring device, or a distance between the first and second measurement positions. The error signal indicating that the non-invasive biological information measuring device is attached to the living body is an error when the time-out threshold C is equal to or greater than a timeout threshold C, which is a criterion for determining whether or not the measurement of the time-out is timed out. It is what.

  According to a third aspect of the present invention, there is provided the noninvasive living body information measuring apparatus according to the first aspect, wherein the mounting confirmation means outputs a detection signal output from the photoacoustic detecting means. Measurement position detection means for detecting the first and second measurement positions based on the output and outputting a measurement start signal and a measurement end signal indicating measurement start and measurement end of the distance between the first and second measurement positions; It has an error detection counter that starts counting based on the measurement start signal and ends counting based on the measurement end signal, and outputs the error signal by comparing the value counted by the error detection counter with a threshold value. And an error detection means.

  A non-invasive living body information measuring apparatus according to claim 4 of the present invention is the non-invasive living body information measuring apparatus according to claim 3, wherein the error detecting means compares with a value counted by the error detecting counter. Is a threshold value for compression A which is a criterion for determining whether or not the living body is pressed by the non-invasive living body information measuring device, and whether or not the living body is pulled by the non-invasive living body information measuring device. A pulling threshold B which is a determination criterion, and a timeout threshold C which is a determination criterion as to whether or not the measurement of the distance between the first and second measurement positions times out, and the error detection means The error signal is output when the value counted by the error detection counter is not more than the compression threshold A, or not less than the pulling threshold B, or not less than the timeout threshold C. The one in which the features.

  The noninvasive living body information measuring apparatus according to claim 5 of the present invention is the noninvasive living body information measuring apparatus according to claim 3, wherein the measurement position detecting means is a detection signal output from the photoacoustic detecting means. And detecting the first measurement position by comparing the detection signal with a threshold value D for the surface of the living body, which is a criterion for determining whether or not the detection signal corresponds to a photoacoustic signal whose energy has been converted on the surface of the living body. , Start outputting a measurement start signal indicating the start of measurement of the distance between the first and second measurement positions, and then the detection signal output from the photoacoustic detection means and the detection signal are transmitted in the blood vessel in the living body. The second measurement position is detected by comparing with a blood vessel threshold value E in the living body, which is a criterion for determining whether or not the photoacoustic signal is subjected to energy conversion, and the first and second measurements. Of distance between positions Starts outputting the measurement end signal indicating a constant completion, it is characterized in.

  A noninvasive living body information measuring apparatus according to claim 6 of the present invention is the noninvasive living body information measuring apparatus according to claim 5, wherein the detection signal output from the photoacoustic detecting means is a threshold value for the surface of the living body. A position that changes from a value higher than D to a lower value is detected as the first measurement position, and output of the measurement start signal is started, and the detection signal is a value higher than a value lower than the threshold value D for the surface of the living body. And the output of the measurement start signal is terminated at a position where the detection signal changes to, and then the position where the detection signal changes from a value higher than the blood vessel threshold E in the living body to a lower value is detected as the second measurement position. Starting the output of the measurement end signal and ending the output of the measurement end signal at a position where the detection signal changes from a value lower than the blood vessel threshold E in the living body to a higher value. It is intended to.

  The noninvasive living body information measuring apparatus according to claim 7 of the present invention is the noninvasive living body information measuring apparatus according to claim 3, wherein the measurement position detecting means includes a low pass filter, When the output time of the measurement start signal and the measurement end signal is short, the measurement start signal and the measurement end signal can be invalidated.

  Moreover, the noninvasive living body information measuring device according to claim 8 of the present invention is the noninvasive living body information measuring device according to claim 7, wherein the low-pass filter has a plurality of externally writable registers, The time for invalidating the measurement start signal and the measurement end signal can be changed by changing a value written in the register.

  Further, the noninvasive living body information measuring apparatus according to claim 9 of the present invention is the noninvasive living body information measuring apparatus according to claim 5, wherein the measurement position detecting means includes a peak position extracting means, The extraction means compares the detection signal with the biological surface threshold D, detects the position where the difference between the detection signal and the biological surface threshold D is the largest as the first measurement position, and then Comparing the detection signal with the blood vessel threshold value E in the living body, and detecting the position where the difference between the detection signal and the blood vessel threshold value E in the living body is the largest as the second measurement position. It is a feature.

  A non-invasive living body information measuring apparatus according to claim 10 of the present invention is the non-invasive living body information measuring apparatus according to claim 2, wherein the first measurement position detected by the mounting confirmation means is the position of the living body. It is a position corresponding to a detection signal generated from a photoacoustic wave signal from the surface.

  Further, the noninvasive living body information measuring apparatus according to claim 11 of the present invention is the noninvasive living body information measuring apparatus according to claim 2, wherein the second measurement position detected by the mounting confirmation means is the in vivo body. It is a position corresponding to the detection signal generated from the photoacoustic wave signal from the blood vessel.

  A noninvasive living body information measuring apparatus according to claim 12 of the present invention is the noninvasive living body information measuring apparatus according to claim 5, wherein the measurement position detecting means compares the detection signal with the detection surface threshold. D and the in-vivo blood vessel threshold value E are respectively predetermined amplitude values for the detection signal.

  A non-invasive living body information measuring apparatus according to claim 13 of the present invention is the non-invasive living body information measuring apparatus according to claim 5, wherein the measurement position detecting means is a detection signal generated by the photoacoustic detecting means. The living body surface threshold value D and the in vivo blood vessel threshold value E to be compared are values of a predetermined inclination with respect to the detection signal, respectively.

  The noninvasive living body information measuring apparatus according to claim 14 of the present invention is the noninvasive living body information measuring apparatus according to claim 5, wherein the measurement position detecting means has a plurality of externally writable registers. The threshold value D for the surface of the living body and the threshold value E for the blood vessel in the living body can be changed by changing the value written in the register.

  Further, the noninvasive living body information measuring apparatus according to claim 15 of the present invention is the noninvasive living body information measuring apparatus according to claim 3, wherein the error signal output by the error detecting means is received by the photoacoustic detecting means. It is output as a result of detecting pressure or tension on the surface of the living body.

  Moreover, the noninvasive living body information measuring device according to claim 16 of the present invention is the noninvasive living body information measuring device according to claim 3, wherein the error detecting means has a plurality of externally writable registers, The compression threshold value A, the pulling threshold value B, and the timeout threshold value C can be changed by changing values to be written in the register.

  A non-invasive living body information measuring apparatus according to claim 17 of the present invention irradiates a surface of a living body with light and transmits a photoacoustic wave signal from the living body including a feature quantity of living body information from the surface of the living body. In the noninvasive living body information measuring device to detect, at least one light source, a control means for controlling the lighting timing of the light source and outputting an activation signal, and based on the activation signal, the light from the living body emitted from the light source A photoacoustic detection unit that detects a photoacoustic wave signal and generates a detection signal, a feature amount estimation unit that estimates a feature amount of biological information from the detection signal generated by the photoacoustic detection unit, and the feature amount estimation unit And a feature amount display means for displaying the feature amount estimated by the method, and counting is started based on the activation signal, and the position extraction is performed when the counted value is equal to or larger than the position extraction threshold value X which is a criterion for starting position measurement. A start signal generation counter that outputs a signal, and the position extraction signal is received to measure the distance between the surface of the living body and the blood vessel in the living body based on the detection signal generated by the photoacoustic detection means; A non-invasive living body information measuring device according to the mounting check means for checking whether or not the living body information is correctly mounted, and an error display means for notifying the user of an error signal output from the mounting check means. It is characterized by that.

  Further, the noninvasive living body information measuring apparatus according to claim 18 of the present invention is the noninvasive living body information measuring apparatus according to claim 17, wherein the mounting confirmation means uses the first measurement position and the second from the detection signal. And measuring the distance between the first and second measurement positions, and determining whether or not the distance is a wearing state in which the living body is compressed by the noninvasive living body information measuring device Is a threshold value for compression A or less, a threshold value for pulling B that is a criterion for determining whether or not the living body is pulled by the noninvasive living body information measuring device, or a distance between the first and second measurement positions. The error signal indicating that the photoacoustic detection means is attached to the living body is an error is output when a time-out threshold C or more, which is a criterion for determining whether or not the measurement of the time-out occurs, is characterized in that Is.

  The noninvasive living body information measuring apparatus according to claim 19 of the present invention is the noninvasive living body information measuring apparatus according to claim 17, wherein the mounting confirmation means outputs a detection signal output from the photoacoustic detecting means. Measurement position detection means for detecting the first and second measurement positions based on the output and outputting a measurement start signal and a measurement end signal indicating measurement start and measurement end of the distance between the first and second measurement positions; It has an error detection counter that starts counting based on the measurement start signal and ends counting based on the measurement end signal, and outputs the error signal by comparing the value counted by the error detection counter with a threshold value. And an error detection means.

  A non-invasive living body information measuring apparatus according to claim 20 of the present invention is the non-invasive living body information measuring apparatus according to claim 19, wherein the error detecting means compares with a value counted by the error detecting counter. Is a threshold value for compression A which is a criterion for determining whether or not the living body is pressed by the non-invasive living body information measuring device, and whether or not the living body is pulled by the non-invasive living body information measuring device. A pulling threshold B which is a determination criterion, and a timeout threshold C which is a determination criterion as to whether or not the measurement of the distance between the first and second measurement positions times out, and the error detection means The error signal is output when the value counted by the error detection counter is not more than the compression threshold A, not less than the pulling threshold B, or not less than the timeout threshold C. It is characterized in.

  The noninvasive living body information measuring apparatus according to claim 21 of the present invention is the noninvasive living body information measuring apparatus according to claim 19, wherein the measurement position detecting means is a detection signal output from the photoacoustic detecting means. And detecting the first measurement position by comparing the detection signal with a threshold value D for the surface of the living body, which is a criterion for determining whether or not the detection signal corresponds to a photoacoustic signal whose energy has been converted on the surface of the living body. , Start outputting a measurement start signal indicating the start of measurement of the distance between the first and second measurement positions, and then the detection signal output from the photoacoustic detection means and the detection signal are transmitted in the blood vessel in the living body. The second measurement position is detected by comparing with a blood vessel threshold value E in the living body, which is a criterion for determining whether or not the photoacoustic signal is subjected to energy conversion, and the first and second measurements. Distance between positions Starts outputting the measurement end signal indicating the end of measurement, it is characterized in.

  The noninvasive living body information measuring apparatus according to claim 22 of the present invention is the noninvasive living body information measuring apparatus according to claim 21, wherein the detection signal output from the photoacoustic detecting means is a threshold value for the surface of the living body. A position that changes from a value higher than D to a lower value is detected as the first measurement position, and output of the measurement start signal is started, and the detection signal is a value higher than a value lower than the threshold value D for the surface of the living body. And the output of the measurement start signal is terminated at a position where the detection signal changes to, and then the position where the detection signal changes from a value higher than the blood vessel threshold E in the living body to a lower value is detected as the second measurement position. , Start outputting the measurement end signal, and end the measurement at a position where the detection signal output from the photoacoustic detection means changes from a value lower than the blood vessel threshold E in the living body to a higher value. It ends the output of the items, and is characterized in.

  The noninvasive living body information measuring apparatus according to claim 23 of the present invention is the noninvasive living body information measuring apparatus according to claim 19, wherein the measurement position detecting means includes a low pass filter, When the output time of the measurement start signal and the measurement end signal is short, the measurement start signal and the measurement end signal can be invalidated.

  A noninvasive living body information measuring apparatus according to claim 24 of the present invention is the noninvasive living body information measuring apparatus according to claim 22, wherein the low-pass filter has a plurality of externally writable registers, The time for invalidating the measurement start signal and the measurement end signal can be changed by changing a value written in the register.

  The noninvasive living body information measuring apparatus according to claim 25 of the present invention is the noninvasive living body information measuring apparatus according to claim 21, wherein the measurement position detecting means includes a peak position extracting means, The extraction means compares the detection signal with the biological surface threshold D, detects the position where the difference between the detection signal and the biological surface threshold D is the largest as the first measurement position, and then Comparing the detection signal with the blood vessel threshold value E in the living body, and detecting the position where the difference between the detection signal and the blood vessel threshold value E in the living body is the largest as the second measurement position. It is a feature.

  A noninvasive living body information measuring apparatus according to claim 26 of the present invention is the noninvasive living body information measuring apparatus according to claim 17, wherein the first measurement position detected by the mounting confirmation means is the position of the living body. It is a position corresponding to a detection signal generated from a photoacoustic wave signal from the surface.

  A non-invasive living body information measuring apparatus according to claim 27 of the present invention is the non-invasive living body information measuring apparatus according to claim 17, wherein the second measurement position detected by the mounting confirmation means is the in vivo body. It is a position corresponding to the detection signal generated from the photoacoustic wave signal from the blood vessel.

  A noninvasive living body information measuring device according to claim 28 of the present invention is the noninvasive living body information measuring device according to claim 21, wherein the measurement position detecting means compares the detection signal with the detection surface threshold. D and the in-vivo blood vessel threshold value E are respectively predetermined amplitude values for the detection signal.

  A non-invasive living body information measuring apparatus according to claim 29 of the present invention is the non-invasive living body information measuring apparatus according to claim 21, wherein the measurement position detecting means is a detection signal generated by the photoacoustic detecting means. The living body surface threshold value D and the in vivo blood vessel threshold value E to be compared are values of a predetermined inclination with respect to the detection signal, respectively.

  The noninvasive living body information measuring apparatus according to claim 30 of the present invention is the noninvasive living body information measuring apparatus according to claim 21, wherein the measurement position detecting means has a plurality of externally writable registers. The threshold value D for the surface of the living body and the threshold value E for the blood vessel in the living body can be changed by changing the value written in the register.

  The noninvasive living body information measuring apparatus according to claim 31 of the present invention is the noninvasive living body information measuring apparatus according to claim 19, wherein the error signal output from the error detecting means is received by the photoacoustic detecting means. It is output as a result of detecting pressure or tension on the surface of the living body.

  Further, the noninvasive living body information measuring device according to claim 32 of the present invention is the noninvasive living body information measuring device according to claim 20, wherein the error detecting means includes a plurality of externally writable registers, The compression threshold value A, the pulling threshold value B, and the timeout threshold value C can be changed by changing values to be written in the register.

  The noninvasive living body information measuring apparatus according to claim 33 of the present invention is the noninvasive living body information measuring apparatus according to claim 17, wherein the start signal generation counter has a register writable from the outside, The position extraction threshold value X can be changed by changing the value written to the register.

  According to a thirty-fourth aspect of the present invention, there is provided a noninvasive living body information measuring apparatus that emits light on the surface of a living body to transmit a photoacoustic wave signal from the living body including a feature amount of living body information from the surface of the living body. In the noninvasive living body information measuring device to detect, at least one light source, a control means for controlling the lighting timing of the light source and outputting an activation signal, and based on the activation signal, the light from the living body emitted from the light source A photoacoustic detection unit that detects a photoacoustic wave signal and generates a detection signal, a feature amount estimation unit that estimates a feature amount of biological information from the detection signal generated by the photoacoustic detection unit, and the feature amount estimation unit And a feature amount display means for displaying the feature amount estimated by the method, and counting is started based on the activation signal, and the position extraction is performed when the counted value is equal to or larger than the position extraction threshold value X which is a criterion for starting position measurement. By receiving a start signal generation counter that outputs a signal and the position extraction signal, a second measurement position of the detection signal generated by the photoacoustic detection unit is detected, and the output timing of the position extraction signal An error that is measured by the distance to the second measurement position and confirms whether or not the non-invasive living body information measuring device is correctly mounted on the living body according to the distance; An error display means for notifying a user of a signal is provided.

  A non-invasive living body information measuring apparatus according to claim 35 of the present invention is the non-invasive living body information measuring apparatus according to claim 34, wherein the mounting confirmation means detects a second measurement position from the detection signal. The distance between the output timing of the position detection signal and the second measurement position is measured, and the distance is a criterion for determining whether or not the living body is pressed by the noninvasive biological information measuring device. Less than the compression threshold A, greater than the pull threshold B, which is a criterion for determining whether or not the living body is pulled by the non-invasive living body information measurement device, or between the output timing of the position extraction signal and the second measurement position The error signal indicating that the photoacoustic detection means is attached to the living body is an error when the distance measurement is equal to or more than a timeout threshold C, which is a criterion for determining whether or not the distance measurement is timed out. The one in which the features.

  A noninvasive living body information measuring apparatus according to claim 36 of the present invention is the noninvasive living body information measuring apparatus according to claim 34, wherein the mounting confirmation means outputs a detection signal output from the photoacoustic detecting means. Measurement position detecting means for detecting the second measurement position based on the output timing and outputting a measurement end signal indicating the measurement end of the distance between the second measurement positions and the output timing of the position extraction signal; An error detection means having an error detection counter that starts counting at an output timing and ends counting based on the measurement end signal, and outputs the error signal by comparing a value counted by the error detection counter with a threshold value It is characterized by having.

  A non-invasive living body information measuring apparatus according to claim 37 of the present invention is the non-invasive living body information measuring apparatus according to claim 36, wherein the error detecting means compares with a value counted by the error detecting counter. Is a threshold value for compression A which is a criterion for determining whether or not the living body is pressed by the non-invasive living body information measuring device, and whether or not the living body is pulled by the non-invasive living body information measuring device. A threshold value for pulling B that is a criterion for determination, and a threshold value for timeout C that is a criterion for determining whether or not the measurement of the distance from the output timing of the position extraction signal to the second measurement position times out, and the error The detection means is configured such that the value counted by the error detection counter is not more than the compression threshold A, or not less than the pulling threshold B, or not less than the timeout threshold C. The outputs an error signal is the m, characterized in that when.

  The noninvasive living body information measuring apparatus according to Claim 38 of the present invention is the noninvasive living body information measuring apparatus according to Claim 36, wherein the measurement position detecting means is configured to detect the photoacoustic detection based on the position extraction signal. The detection signal output from the means is compared with the in-vivo blood vessel threshold value E which is a criterion for determining whether or not the detection signal corresponds to the photoacoustic signal whose energy has been converted in the in-vivo blood vessel. The second measurement position is detected, and the output of the measurement end signal indicating the end of the measurement of the distance between the output timing of the position extraction signal and the second measurement position is started.

  A non-invasive living body information measuring apparatus according to claim 39 of the present invention is the non-invasive living body information measuring apparatus according to claim 38, wherein the detection signal output from the photoacoustic detecting means is used for blood vessels in the living body. A position that changes from a value higher than the threshold value E to a lower value is detected as the second measurement position, and the detection signal output from the photoacoustic detection means changes from a value lower than the blood vessel threshold value E in the living body to a higher value. The output of the measurement end signal is terminated at the changing position.

  The noninvasive living body information measuring apparatus according to claim 40 of the present invention is the noninvasive living body information measuring apparatus according to claim 36, wherein the measurement position detecting means includes a low pass filter, When the output time of the measurement end signal is short, the measurement end signal can be invalidated.

  A non-invasive living body information measuring device according to claim 41 of the present invention is the non-invasive living body information measuring device according to claim 40, wherein the low-pass filter has an externally writable register. It is possible to change the time for invalidating the measurement end signal by changing the value.

  The noninvasive living body information measuring apparatus according to claim 42 of the present invention is the noninvasive living body information measuring apparatus according to claim 38, wherein the measurement position detecting means includes a peak position extracting means, The extraction means compares the detection signal with the blood vessel threshold value E in the living body, and detects the position where the difference between the detection signal and the blood vessel threshold value E in the living body is the largest as the second measurement position. It is characterized by that.

  A non-invasive living body information measuring apparatus according to claim 43 of the present invention is the non-invasive living body information measuring apparatus according to claim 38, wherein the second measurement position measured by the mounting confirmation means is the in-vivo body measuring apparatus. It is a position corresponding to the detection signal generated from the photoacoustic wave signal from the blood vessel.

  A noninvasive living body information measuring apparatus according to claim 44 of the present invention is the noninvasive living body information measuring apparatus according to claim 38, wherein the measurement position detecting means compares the detection signal with the in vivo blood vessel. The threshold E is a predetermined amplitude value for the detection signal.

  A noninvasive living body information measuring device according to claim 45 of the present invention is the noninvasive living body information measuring device according to claim 38, wherein the measurement position detecting means compares the detection signal with the in vivo blood vessel. The threshold value E is a value of a predetermined inclination with respect to the detection signal.

  The noninvasive living body information measuring device according to claim 46 of the present invention is the noninvasive living body information measuring device according to claim 36, wherein the measurement position detecting means has a register writable from the outside, It is possible to change the blood vessel threshold value E in the living body by changing a value written in the register.

  According to a 47th aspect of the present invention, in the noninvasive living body information measuring apparatus according to the 36th aspect, the error signal output by the error detecting means is obtained by the photoacoustic detecting means. It is output as a result of detecting pressure or tension on the surface of the living body.

  Further, the noninvasive living body information measuring device according to Claim 48 of the present invention is the noninvasive living body information measuring device according to Claim 37, wherein the error detecting means has a plurality of externally writable registers, The compression threshold value A, the pulling threshold value B, and the timeout threshold value C can be changed by changing values to be written in the register.

  The noninvasive living body information measuring device according to claim 48 of the present invention is the noninvasive living body information measuring device according to claim 34, wherein the start signal generation counter has a register writable from the outside, The position extraction threshold value X can be changed by changing the value written to the register.

  According to the non-invasive living body information measuring device of the present invention, the distance between the measurement positions detected from the photoacoustic wave signal returned from the living body after the non-invasive living body information measuring device is mounted on the living body and irradiated with light. Since the measurement device itself determines whether or not the non-invasive living body information measuring device is properly attached to the living body according to whether or not it is the same as when correctly attached, without increasing the size of the device An attachment error of the photoacoustic detection means to the living body can be detected. For this reason, when the noninvasive living body information measuring device is a noninvasive blood sugar level measuring device, it can prevent beforehand that a patient will administer insulin based on a wrong blood sugar level.

Embodiments of the noninvasive living body information measuring apparatus of the present invention will be described below in detail with reference to the drawings.
(Embodiment 1)

  In Embodiment 1 of the present invention, it is assumed that the noninvasive biological information measuring device is a noninvasive blood glucose measuring device.

  FIG. 1 is a diagram showing a state when the noninvasive living body information measuring apparatus according to Embodiment 1 of the present invention is mounted on a living body.

  In FIG. 1, 101 is a non-invasive blood glucose measuring device, 102 is the surface of a living body, 103 is irradiation light, 104 is a blood vessel, and 105 is a photoacoustic wave signal. FIG. 1A is a diagram showing a state where the non-invasive blood glucose measuring device 101 is normally attached, and FIG. 1B is a case where the non-invasive blood glucose measuring device 101 is abnormally attached (the non-invasive blood glucose measuring device is a living body). FIG. 1 (c) shows a state when the non-invasive blood glucose measuring device 101 is abnormally attached (the surface 102 of the living body is pulled by the non-invasive blood glucose measuring device). FIG.

  The noninvasive blood glucose measuring device 101 is mounted so as to be in contact with the surface 102 of the living body, and the irradiation light 103 irradiated by the noninvasive blood glucose measuring device 101 is incident on the living body. The irradiation light 103 propagates in the living body and is absorbed by glucose in the blood flowing in the blood vessel 104, and a photoacoustic wave signal 105 is generated. The non-invasive blood glucose measuring device 101 detects a photoacoustic wave signal 105 generated by glucose in the blood vessel 104 and estimates a blood glucose level that is a feature amount of biological information.

  FIG. 2 is a diagram showing a block configuration of the noninvasive blood glucose measurement device 101 according to Embodiment 1 of the present invention.

  In FIG. 2, 201 is a light source that emits light from the surface of a living body, 202 is a control unit that controls lighting timing of the light source 201 and outputs an activation signal, and 203 is an activation signal from the control unit 202. Based on the photoacoustic wave detection means for detecting the photoacoustic wave signal from the living body by the irradiation light of the light source 201 and generating the detection signal, 204 is a feature quantity of the biological information from the detection signal generated by the photoacoustic detection means 203. Feature quantity estimation means for estimation, 205 is a feature quantity display means for displaying the feature quantity of the biological information estimated by the feature quantity estimation means 204, 206 is a start signal generation counter to which an activation signal 212 is input, and 207 is a detection signal 213. Is a mounting confirmation means 208 to which is input, and 208 is an error display means for displaying an error signal 215.

  Also, 211 is a control signal, 212 is an activation signal, 213 is a detection signal, 214 is a position extraction signal, 215 is an error signal, 216 is a blood glucose level, and 221 is a threshold value X for position extraction.

  The light source 201 includes at least one light source 201 and emits irradiation light 103 having a wavelength equal to the wavelength absorbed by glucose.

  The control means 202 outputs a control signal 211 such as the lighting timing of the light source 201, turns on the light source 201, and outputs an activation signal 212.

  The photoacoustic detection unit 203 detects the photoacoustic wave signal 105 based on the activation signal 212 from the control unit 202 and generates a detection signal 213.

  The feature amount estimation unit 204 estimates the blood glucose level 216 from the detection signal 213 generated by the photoacoustic detection unit 203.

  The feature amount display unit 205 displays the blood sugar level 216 estimated by the feature amount estimation unit 204.

  The start signal generation counter 206 starts counting based on the activation signal 212 from the control means 202, and outputs a position extraction signal 214 when the counted value is equal to or larger than a preset position extraction threshold X (221).

  The mounting confirmation unit 207 detects the first measurement position and the second measurement position from the detection signal 213 generated by the photoacoustic detection unit 203 based on the position extraction signal 214 from the start signal generation counter 206, and the first measurement position is detected. The time between the measurement position and the second measurement position is measured, and the measured time is either a threshold value for compression A (321) or less, a threshold value for tension B (322) or more, or a threshold value for timeout C (323) or more. When this is true, an error signal 215 is output. The compression threshold A is a criterion for determining whether or not the living body is in a wearing state in which the living body is compressed by the noninvasive living body information measuring apparatus. The pulling threshold B is a criterion for determining whether or not the living body is pulled by the non-invasive living body information measuring apparatus. Further, the timeout threshold C is a criterion for determining whether or not the distance between the first and second measurement positions, that is, the measurement of the time difference is a timeout.

  The error display unit 208 notifies the error signal 215 output from the mounting confirmation unit 207.

  FIG. 3 is a diagram showing a block configuration of the mounting confirmation unit 207 according to Embodiment 1 of the present invention.

  In FIG. 3, 301 is a measurement position detection means, 302 is an error detection counter, 303 is an error detection means, 304 is a low-pass filter, and 305 is a peak position extraction means.

  311 is a measurement start signal, 312 is a measurement end signal, 321 is a compression threshold A, 322 is a pulling threshold B, and 323 is a timeout threshold C. Reference numeral 324 denotes a living body surface threshold D, which is a criterion for determining whether or not the detection signal output from the photoacoustic detection unit 203 corresponds to a photoacoustic signal whose energy has been converted on the surface of the living body. Reference numeral 325 denotes a blood vessel threshold value E in the living body, which is a criterion for determining whether or not the detection signal output from the photoacoustic detection means 203 corresponds to a photoacoustic signal whose energy has been converted in the blood vessel in the living body. 326 to 329 are invalid time register groups, 326 is an invalid time threshold before LPF start, 327 is an invalid time threshold after LPF start, 328 is an invalid time threshold before LPF end, and 329 is an invalid time threshold after LPF end. Each is written.

  The measurement position detection unit 301 includes a low-pass filter 304 and a peak position extraction unit 305, and is set in advance with the detection signal 213 generated by the photoacoustic detection unit 203 based on the position extraction signal 214 from the start signal generation counter 206. And a position where the detection signal 213 changes from a value higher than the threshold value D (324) for the surface of the living body to a lower value is detected as the first measurement position, and measurement is performed. The output of the start signal 311 is started, and the output of the measurement start signal 311 is terminated at a position where the detection signal 213 changes from a value lower than the biological surface threshold D (324) to a higher value. Compared with the in-vivo threshold value E (325) in the living body, is the detection signal 213 higher than the in-vivo threshold value E (325) in the living body? A position where the position that changes to a low value is detected as the second measurement position and the output of the measurement end signal 312 is started, and the detection signal 213 changes from a value lower than the blood vessel threshold value E (325) in the living body Then, the output of the measurement end signal 312 is finished.

  The error detection counter 302 starts counting based on the measurement start signal 311 output from the measurement position detection unit 301 and ends counting based on the measurement end signal 312.

  The error detection means 303 includes an error detection counter 302, and a value counted by the error detection counter 302 and a preset compression threshold A (321), pulling threshold B (322), or timeout threshold C (323). And the error signal 215 is output when the counted value is equal to or less than the compression threshold A (321) or the pulling threshold B (322). Even when the measurement position cannot be detected, the value counted by the error detection counter 302 is compared with a preset timeout threshold C (323), and when the counted value is equal to or greater than the timeout threshold C (323). An error signal 215 is output. The output error signal 215 is notified by the error display means 208.

  The low-pass filter 304 invalidates the measurement start signal and the measurement end signal when the output time of the measurement start signal and the measurement end signal is short.

  The peak position extraction unit 305 compares the detection signal 213 output from the photoacoustic detection unit 203 with the biological surface threshold D (324), and the difference between the detection signal and the biological surface threshold D (324). Is detected as the first measurement position, and then the detection signal 213 and the in-vivo blood vessel threshold value E (325) are compared, and the detection signal 213 and the in-vivo blood vessel threshold value E (325) are compared. Is detected as the second measurement position.

  FIG. 4 is a diagram showing a detailed operation of the measurement position detecting unit 301 in the first embodiment of the present invention.

  In FIG. 4, (a) shows a case where a short waveform change occurs when the detection signal 213 changes from a value higher than the biological surface threshold D (324) to a lower value, and (d) shows the detection signal 213. Shows a case where a short waveform change occurs when the value changes from a lower value to a higher value than the biological surface threshold D (324), and (b) and (e) show the detection signal 213 as the biological surface threshold D. (324) A real-time detection signal that outputs a Lo level when it is higher and a Hi level when it is lower. (C) and (f) show a measurement start signal 311 obtained by filtering the real-time detection signal by the low-pass filter 304. Show.

  Here, each of the invalid time register groups (having an invalid time threshold before starting LPF 326, an invalid time threshold after starting LPF 327, an invalid time threshold before ending LPF 328, and an invalid time threshold after ending LPF 329) has a measurement start signal 311 respectively. In addition, a continuous output time for enabling the measurement end signal 312 is set in advance.

  First, using FIGS. 4A, 4B, and 4C, when the detection signal 213 (a) changes from a higher value to a lower value than the biological surface threshold D (324), a short waveform change is performed. The operation of the measurement position detection unit 301 when the error occurs will be described.

  At ts0, the measurement position detection unit 301 compares the detection signal 213 with the biological surface threshold D (324). At this time, since the detection signal 213 is lower than the biological surface threshold D (324), the real-time detection signal is output at the Hi level. The measurement start signal 311 is at the Lo level after the change is cut by the low-pass filter 304.

  At ts1, similarly to ts0, the detection signal 213 is lower than the biological surface threshold D (324), so the real-time detection signal is output at the Hi level. The measurement start signal 311 is compared with the continuous output time of the real-time detection signal (b: time of ts0 to ts1) by the low-pass filter 304 and the invalid time threshold 326 before the LPF start, and the continuous output time of the real-time detection signal is before the LPF start. Since it is shorter than the invalid time threshold value 326, the output real-time detection signal is invalidated to the Lo level.

  At ts2, since the detection signal 213 is higher than the threshold value D (324) for the living body surface, the real-time detection signal is output at the Lo level. The measurement start signal 311 is not changed by the low-pass filter 304 and remains at the Lo level.

  At ts3, the detection signal 213 becomes lower than the biological surface threshold D (324) again, so the real-time detection signal is output at the Hi level. The measurement start signal 311 is at the Lo level after the change is cut by the low-pass filter 304.

  At ts4, as in ts3, the detection signal 213 is lower than the biological surface threshold D (324), so the real-time detection signal is output at the Hi level. The measurement start signal 311 is compared by the low-pass filter 304 between the continuous output time of the real-time detection signal (b: time of ts3 to ts4) and the invalid time threshold 326 before the LPF start, and the continuous output time of the real-time detection signal is before the LPF start. Since it is longer than the invalid time threshold 326, the output real-time detection signal is validated and becomes Hi level.

  At ts5, since the detection signal 213 is higher than the biological surface threshold D (324), the real-time detection signal is output at the Lo level. The change in the measurement start signal 311 is cut by the low-pass filter 304 and remains at the Hi level.

  At ts6, as in ts5, the detection signal 213 is higher than the biological surface threshold D (324), so the real-time detection signal is output at the Lo level. The measurement start signal 311 is compared by the low-pass filter 304 between the continuous output time of the real-time detection signal (b: time of ts5 to ts6) and the invalid time threshold 327 after the start of LPF, and the continuous output time of the real-time detection signal after the LPF starts. Since it is longer than the invalid time threshold value 327, the output real-time detection signal is validated and then becomes Lo level.

  Next, using FIGS. 4D, 4E, and 4F, when the detection signal 213 (d) changes from a lower value to a higher value than the biological surface threshold D (324), a short waveform is obtained. An operation of the low-pass filter 304 when a change occurs will be described.

  In te0, the measurement position detection unit 301 compares the detection signal 213 with the biological surface threshold D (324). At this time, since the detection signal 213 is lower than the biological surface threshold D (324), the real-time detection signal is output at the Hi level. The measurement start signal 311 is at the Lo level after the change is cut by the low-pass filter 304.

  In te1, as in te0, the detection signal 213 is lower than the biological surface threshold D (324), so the real-time detection signal is output at the Hi level. The measurement start signal 311 is compared with the continuous output time of the real-time detection signal (e: time from te0 to te1) by the low-pass filter 304 and the invalid time threshold 326 before the LPF start, and the continuous output time of the real-time detection signal is before the LPF start. Since it is longer than the invalid time threshold 326, the output real-time detection signal is validated and becomes Hi level.

  In te2, since the detection signal 213 is higher than the biological surface threshold D (324), the real-time detection signal is output at the Lo level. The change in the measurement start signal 311 is cut by the low-pass filter 304 and remains at the Hi level.

  In te3, since the detection signal 213 is again higher than the biological surface threshold D (324), the real-time detection signal is output at the Lo level. The measurement start signal 311 is compared with the continuous output time of the real time detection signal (e: time from te2 to te3) by the low pass filter 304 and the invalid time threshold 327 after the start of LPF, and the continuous output time of the real time detection signal is after the LPF starts. Since it is shorter than the invalid time threshold value 327, the output real-time detection signal is invalidated and remains at the Hi level.

  In te4, since the detection signal 213 is lower than the biological surface threshold D (324), the real-time detection signal is output at the Hi level. The change in the measurement start signal 311 is cut by the low-pass filter 304 and remains at the Hi level.

  In te5, similarly to te4, the detection signal 213 is lower than the biological surface threshold D (324), so the real-time detection signal is output at the Hi level. The measurement start signal 311 is cut by the low-pass filter 304 and remains at the Hi level.

  In te6, since the detection signal 213 becomes higher than the biological surface threshold D (324) again, the real-time detection signal is output at the Lo level. The measurement start signal 311 is cut by the low-pass filter 304 and remains at the Hi level.

  In te7, similarly to te6, since the detection signal 213 is higher than the biological surface threshold D (324), the real-time detection signal is output at the Lo level. The measurement start signal 311 is compared by the low-pass filter 304 between the continuous output time of the real-time detection signal (e: time from te6 to te7) and the invalid time threshold 327 after the start of LPF, and the continuous output time of the real-time detection signal after the LPF starts. Since it is longer than the invalid time threshold value 327, the output real-time detection signal is validated and becomes Lo level.

  Regarding the measurement end signal 312, the same applies if the LPF start invalid time threshold value 326 included in the low pass filter 304 is replaced with the LPF start invalid time threshold value 328, and the LPF start invalid time threshold value 327 is replaced with the LPF end invalid time threshold value 329. Since the explanation of is established, the explanation is omitted.

  FIG. 5 is a diagram showing a timing chart when the non-invasive blood glucose measuring device 101 according to Embodiment 1 of the present invention is normally attached.

  5, (a) is a start signal 212, (b) is a detection signal 213, (c) is a start signal generation counter 206, (d) is a position extraction signal 214, (e) is an error detection counter 302, (f) ) Is an error signal 215.

  Hereinafter, the operation when the noninvasive blood glucose measurement device 101 is normally attached to the surface 102 of the living body will be described with reference to FIGS. 1, 2, 3, and 5.

Here, the following values are set for the respective threshold values. That is,
Compression threshold A (321): Time from the first measurement position detected as an attachment error to the second measurement position Pull threshold B (322): Second measurement from the first measurement position detected as an attachment error Time to position Time-out threshold C (323): Time to timeout in measurement from the first measurement position to the second measurement position Biological surface threshold D (324): Detection signal at the first measurement position In-vivo blood vessel threshold E (325): Amplitude of detection signal 213 at the second measurement position Position extraction threshold X (221): From lighting of the light source 201 until detection of the measurement position is started Set each time in advance.

  First, as shown in FIG. 1A, the non-invasive blood glucose measuring device 101 is attached to the surface 102 of a living body such as a patient's arm. Thereafter, when the patient activates a blood glucose level measurement start switch (not shown) provided in the non-invasive blood glucose measuring device 101, the control means 211 outputs a control signal 211 such as the lighting timing of the light source 201, and the light source 201 is turned on. In addition, an activation signal 212 is output (FIG. 5A: t50).

  Irradiation light 103 from the light source 201 propagates through the living body and is absorbed by glucose in the blood vessel 104 to generate a photoacoustic wave signal 105.

  When the photoacoustic detection unit 203 receives the activation signal 212 from the control unit 202, detection of the photoacoustic wave signal 105 is started, and a detection signal 213 (FIG. 5B) is generated.

  When the start signal generation counter 206 detects the activation signal 212 from the control means 202, the count is started and continues until the position extraction threshold value X (221) is reached (FIG. 5C). When the value counted by the start signal generation counter 206 becomes equal to or greater than the position extraction threshold value X (221) (t51), the position extraction signal 214 starts to detect the first measurement position and the second measurement position. Is output (FIG. 5D).

  When the position extraction signal 214 output from the start signal generation counter 206 is detected by the measurement position detection means 301, the amplitude of the detection signal 213 and the threshold for the surface of the living body are detected in order to detect the first measurement position from the detection signal 213. D (324) is compared. When the amplitude of the detection signal 213 is equal to or greater than the biological surface threshold D (324), the first measurement position (t52) is detected and the output of the measurement start signal 311 is started. Further, in order to detect the second measurement position from the detection signal 213, the amplitude of the detection signal 213 is compared with the blood vessel threshold value E (325) in the living body. When the amplitude of the detection signal 213 is equal to or greater than the blood vessel threshold E (325) in the living body, the second measurement position (t53) is detected, and the measurement end detection unit 301 outputs the measurement end signal 312. Since the detection of the first measurement position and the second measurement position has been described with reference to FIG. 3, the description thereof is omitted here.

  When the measurement start signal 311 from the measurement position detection unit 301 is detected by the error detection counter 302 included in the error detection unit 303, the count is started, and the count is continued until the measurement end signal 312 is detected (FIG. 5 (e)). )). The error detection means 303 compares the value counted by the error detection counter 302 at the output timing of the measurement end signal 312 with a preset compression threshold A (321) or tension threshold B (322). When the non-invasive blood sugar measuring device 101 is normally worn, the counted value becomes a value between the compression threshold A (321) and the pulling threshold B (322), and therefore the error signal 215 (FIG. 5 (f): t54) is not output. In addition, at the output timing (t54) of the error signal 215, the count value of the error detection counter 302 is reset.

  When the feature amount estimation unit 204 detects that the error signal 215 is not output from the error detection unit 303 (t55), the blood sugar level 216 is obtained from the detection signal 213 generated by the photoacoustic detection unit 203, Displayed by the feature amount display means 205.

  FIG. 6 is a timing chart when the non-invasive blood sugar measuring device 101 is abnormally worn according to Embodiment 1 of the present invention, that is, when the non-invasive blood sugar measuring device 101 is pressed against the surface 102 of the living body. It is.

  6, (a) is a start signal 212, (b) is a detection signal 213, (c) is a start signal generation counter 206, (d) is a position extraction signal 214, (e) is an error detection counter 302, (f) ) Is an error signal 215.

  Hereinafter, the operation when the noninvasive blood glucose measurement device 101 is pressed against the surface 102 of the living body and mounted will be described with reference to FIGS. 1, 2, 3, and 6.

Here, the following values are set for the respective threshold values. That is,
Compression threshold A (321): Time from the first measurement position detected as an attachment error to the second measurement position Pull threshold B (322): Second measurement from the first measurement position detected as an attachment error Time to position Time-out threshold C (323): Time to timeout in measurement from the first measurement position to the second measurement position Biological surface threshold D (324): Detection signal at the first measurement position In-vivo blood vessel threshold E (325): Amplitude of detection signal 213 at the second measurement position Position extraction threshold X (221): From lighting of the light source 201 until detection of the measurement position is started Set each time in advance.

  First, as shown in FIG. 1B, the noninvasive blood glucose measurement device 101 is attached to the surface 102 of a living body such as a patient's arm. Thereafter, when the patient activates a blood glucose level measurement start switch (not shown) provided in the non-invasive blood glucose measuring device 101, the control means 211 outputs a control signal 211 such as the lighting timing of the light source 201, and the light source 201 is turned on. At the same time, an activation signal 212 is output (FIG. 6A: t60).

  Irradiation light 103 from the light source 201 propagates through the living body and is absorbed by glucose in the blood vessel 104 to generate a photoacoustic wave signal 105.

  When the photoacoustic detection unit 203 receives the activation signal 212 from the control unit 202, detection of the photoacoustic wave signal 105 is started, and a detection signal 213 (FIG. 6B) is generated.

  When the start signal generation counter 206 detects the activation signal 212 from the control means 202, the count is started, and the count is continued until the position extraction threshold value X (221) is reached (FIG. 6C). When the value counted by the start signal generation counter 206 becomes equal to or greater than the position extraction threshold value X (221) (t61), the position extraction signal 214 starts to detect the first measurement position and the second measurement position. Is output (FIG. 6D).

  When the position extraction signal 214 output from the start signal generation counter 206 is detected by the measurement position detection means 301, the amplitude of the detection signal 213 and the threshold for the surface of the living body are detected in order to detect the first measurement position from the detection signal 213. D (324) is compared. When the amplitude of the detection signal 213 is equal to or greater than the biological surface threshold D (324), the first measurement position (t62) is detected and the output of the measurement start signal 311 is started. Further, in order to detect the second measurement position from the detection signal 213, the amplitude of the detection signal 213 is compared with the blood vessel threshold value E (325) in the living body. When the amplitude of the detection signal 213 is equal to or greater than the blood vessel threshold value E (325) in the living body, the second measurement position (t63) is detected, and the measurement position detection unit 301 outputs the measurement end signal 312. Since the detection of the first measurement position and the second measurement position has been described with reference to FIG. 3, the description thereof is omitted here.

  When the measurement start signal 311 from the measurement position detection unit 301 is detected by the error detection counter 302 included in the error detection unit 303, the count starts, and continues until the measurement end signal 312 is detected (FIG. 6 (e)). )). The error detection means 303 compares the value counted by the error detection counter 302 at the output timing of the measurement end signal 312 with a preset compression threshold A (321). When the non-invasive blood glucose measuring device 101 is mounted so as to press the surface of the living body, the counted value becomes a value equal to or smaller than the compression threshold A (321), and therefore the error signal 215 (FIG. 6 (f)). : T64) is output. In addition, at the output timing (t64) of the error signal 215, the count value of the error detection counter 302 is reset.

  When it is detected that the error signal 215 is output (t65), the error display means 208 notifies the mounting error.

  FIG. 7 is a timing chart when the non-invasive blood glucose measuring device 101 according to the first embodiment of the present invention is abnormally worn, that is, when the surface 102 of the living body is pulled by the non-invasive blood glucose measuring device 101. It is.

  7, (a) is a start signal 212, (b) is a detection signal 213, (c) is a start signal generation counter 206, (d) is a position extraction signal 214, (e) is an error detection counter 302, (f ) Is an error signal 215.

  Hereinafter, the operation when the surface 102 of the living body is pulled by the noninvasive blood glucose measurement device 101 will be described with reference to FIGS. 1, 2, 3, and 7.

Here, the following values are set for the respective threshold values. That is,
Compression threshold A (321): Time from the first measurement position detected as an attachment error to the second measurement position Pull threshold B (322): Second measurement from the first measurement position detected as an attachment error Time to position Time-out threshold C (323): Time to timeout in measurement from the first measurement position to the second measurement position Biological surface threshold D (324): Detection signal at the first measurement position In-vivo blood vessel threshold E (325): Amplitude of detection signal 213 at the second measurement position Position extraction threshold X (221): From lighting of the light source 201 until detection of the measurement position is started Set each time in advance.

  First, as shown in FIG. 1C, the noninvasive blood glucose measurement device 101 is attached to the surface 102 of a living body such as a patient's arm. Thereafter, when the patient activates a blood glucose level measurement start switch (not shown) provided in the non-invasive blood glucose measuring device 101, the control means 211 outputs a control signal 211 such as the lighting timing of the light source 201, and the light source 201 is turned on. In addition, an activation signal 212 is output (FIG. 7A: t70).

  Irradiation light 103 from the light source 201 propagates through the living body and is absorbed by glucose in the blood vessel 104 to generate a photoacoustic wave signal 105.

  When the photoacoustic detection unit 203 receives the activation signal 212 from the control unit 202, detection of the photoacoustic wave signal 105 is started, and a detection signal 213 (FIG. 7B) is generated.

  When the start signal generation counter 206 detects the activation signal 212 from the control means 202, the count is started, and the count is continued until the position extraction threshold value X (221) or more is reached (FIG. 7C). When the value counted by the start signal generation counter 206 becomes equal to or greater than the position extraction threshold value X (221) (t71), the position extraction signal 214 is output so as to start detection of the first measurement position and the second measurement position. (FIG. 7D).

  When the position extraction signal 214 output from the start signal generation counter 206 is detected by the measurement position detection means 301, the amplitude of the detection signal 213 and the threshold for the surface of the living body are detected in order to detect the first measurement position from the detection signal 213. D (324) is compared. When the amplitude of the detection signal 213 is equal to or greater than the biological surface threshold D (324), the first measurement position (t72) is detected and the output of the measurement start signal 311 is started. Further, in order to detect the second measurement position from the detection signal 213, the amplitude of the detection signal 213 is compared with the blood vessel threshold value E (325) in the living body. When the amplitude of the detection signal 213 is equal to or greater than the blood vessel threshold E (325) in the living body, the second measurement position (t73) is detected, and the measurement position detection unit 301 outputs the measurement end signal 312. Since the detection of the first measurement position and the second measurement position has been described with reference to FIG. 3, the description thereof is omitted here.

  When the measurement start signal 311 from the measurement position detection unit 301 is detected by the error detection counter 302 included in the error detection unit 303, the count starts, and continues until the measurement end signal 312 is detected (FIG. 7 (e)). )). The error detection means 303 compares the value counted by the error detection counter 302 at the output timing of the measurement end signal 312 with a preset pulling threshold B (322). When the non-invasive blood glucose measuring device 101 is attached so as to pull the surface of the living body, the counted value becomes a value equal to or larger than the pulling threshold B (322), so that the error signal 215 (FIG. 7 (f): t74) is output. In addition, at the output timing (t74) of the error signal 215, the count value of the error detection counter 302 is reset.

  When it is detected that the error signal 215 has been output (t75), the error display means 208 notifies the mounting error.

  As described above, according to the first embodiment of the present invention, by providing the mounting confirmation means 207, the first measurement position and the second measurement position are detected from the detection signal 213, and the first and second measurement positions are detected. By measuring the time between measurement positions and determining whether this corresponds to the time when it is normally worn by comparing it with a threshold value, it is possible to determine whether or not there is a wearing error due to the measurement operation of the noninvasive blood glucose measuring device. Since it can be determined, it becomes possible to detect a mounting error without increasing the size of the non-invasive blood glucose measuring device, and to prevent the patient from administering insulin based on an incorrect blood glucose level. it can.

  In the first embodiment of the present invention, the biological surface threshold D (324) and the biological blood vessel threshold E (325) are detected signals 213 at the first measurement position and the second measurement position, respectively. However, the inclination of the detection signal 213 at the first measurement position and the second measurement position may be used, and similar results can be obtained.

  Further, in the first embodiment of the present invention, by providing the start signal generation counter 206, a waiting time from the activation signal 212 output from the control means 202 to the preset position extraction threshold value X (221) is provided. In the above description, the first measurement position and the second measurement position are detected. However, by setting so as not to generate a signal that exceeds the threshold value D (324) for the living body before the first measurement position. The start signal generation counter 206 may be omitted, and a similar result can be obtained.

  In Embodiment 1 of the present invention, the low-pass filter 304 is provided in the measurement position detection unit 301. However, the noise of the detection signal 213 is provided in the photoacoustic detection unit 203 to remove the influence of disturbance. Components may be removed, and the same effect can be obtained.

  Furthermore, in the first embodiment of the present invention, the measurement position detection unit 301 detects a position where the detection signal 213 changes from a value lower than the biological surface threshold D (324) as a first value as the first measurement position. The position where the detection signal 213 changes from a value higher than the blood vessel threshold value E (325) in the living body to a lower value is detected as the second measurement position, but the peak position extraction in the measurement position detection means 301 is detected. The means 305 detects, as the first measurement peak position, the position where the difference between the detection signal 213 and the biological surface threshold D (324) is the maximum during the period when the measurement start signal 311 is valid, and then the measurement end signal The position where the difference between the detection signal 213 and the blood vessel threshold value E (325) in the living body is the largest is detected as the second measurement peak position during the period in which 312 is valid, and the error detection counter 302 May be counted a first measurement peak position and time of the second measurement peak positions from, it is possible to obtain the same effect.

(Embodiment 2)
In Embodiment 2 of the present invention, it is assumed that the noninvasive biological information measuring device is a noninvasive blood glucose measuring device.

  Since the appearance and block diagram of the noninvasive living body information measuring apparatus according to the second embodiment of the present invention when mounted on a living body are the same as those of the first embodiment except for the mounting confirmation means 207, description thereof will be omitted.

  FIG. 8 is a diagram showing a block configuration of the mounting confirmation unit 207 according to Embodiment 2 of the present invention.

  In FIG. 8, reference numeral 801 denotes a measurement position detection unit, 802 denotes an error detection counter, and 803 denotes an error detection unit.

  Based on the position extraction signal 214 from the start signal generation counter 206, the measurement position detection unit 801 uses the detection signal 213 generated by the photoacoustic detection unit 203 and a preset in-vivo blood vessel threshold value E (325). The second measurement position is extracted by comparison, and a measurement end signal 312 is output.

  The error detection counter 802 starts counting based on the position extraction signal 214 from the start signal generation counter 206, and further ends counting based on the measurement end signal 312.

  The error detection means 803 compares the value counted by the error detection counter 802 with a preset compression threshold A (321), pulling threshold B (322), or timeout threshold C (323) and counts them. When the value is equal to or less than the compression threshold A (321) or the tension threshold B (322), an error signal 215 is output. Even when the measurement position cannot be detected, the error signal 215 is output when the value counted by the error detection counter 802 is equal to or greater than the timeout threshold C (323). The output error signal is notified by the error display means 208.

  FIG. 9 is a diagram showing a timing chart when the non-invasive blood sugar measurement device 101 according to the second embodiment of the present invention is normally attached.

  9, (a) is a start signal 212, (b) is a detection signal 213, (c) is a start signal generation counter 206, (d) is a position extraction signal 214, (e) is an error detection counter 802, (f ) Is an error signal 215.

  Hereinafter, the operation when the noninvasive blood glucose measurement device 101 is normally attached to the surface 102 of the living body will be described with reference to FIGS. 1, 2, 7, and 9.

Here, the following values are set for the respective threshold values. That is,
Compression threshold A (321): Time from turning on the light source 201 detected as an attachment error to the second measurement position Pull threshold B (322): Second after turning on the light source 201 detected as an attachment error Time-out threshold C (323): Time to timeout in measurement from the light source 201 to the second measurement position In-vivo blood vessel threshold E (325): Second measurement position Amplitude position detection threshold value X (221) at ## EQU2 ## The time from when the light source 201 is turned on until the second measurement position is detected is set in advance.

  First, as shown in FIG. 1A, the non-invasive blood glucose measuring device 101 is attached to the surface 102 of a living body such as a patient's arm. Thereafter, when the patient activates a blood glucose level measurement start switch (not shown) provided in the non-invasive blood glucose measuring device 101, the control means 211 outputs a control signal 211 such as the lighting timing of the light source 201, and the light source 201 is turned on. In addition, an activation signal 212 is output (FIG. 9A: t90).

  Irradiation light 103 from the light source 201 propagates through the living body and is absorbed by glucose in the blood vessel 104 to generate a photoacoustic wave signal 105.

  When the photoacoustic detection unit 203 receives the activation signal 212 from the control unit 202, detection of the photoacoustic wave signal 105 is started, and a detection signal 213 (FIG. 9B) is generated.

  When the start signal generation counter 206 detects the activation signal 212 from the control means 202, the count is started, and the count is continued until the position extraction threshold value X (221) is reached (FIG. 9C). When the value counted by the start signal generation counter 206 becomes equal to or greater than the position extraction threshold value X (221) (t91), the position extraction signal 214 is output so as to start detection of the second measurement position (FIG. 9). (D)).

  When the position extraction signal 214 output from the start signal generation counter 206 is detected by the measurement position detection means 801, the second measurement position is detected from the detection signal 213, so that the amplitude of the detection signal 213 and the blood vessel in vivo are detected. The threshold value E (325) is compared. When the amplitude of the detection signal 213 is greater than or equal to the blood vessel threshold E (325) in the living body, the second measurement position (t92) is detected and the measurement end signal 312 is output. Since the detection of the second measurement position has been described with reference to FIG. 3, the description thereof is omitted here.

  The error detection counter 802 provided in the error detection means 803 starts counting when the position extraction signal 214 from the start signal generation counter 206 is detected, and continues counting until the measurement end signal 312 is detected (FIG. 9 (e) )). The error detection means 803 compares the value counted by the error detection counter 802 at the output timing of the measurement end signal 312 with a preset compression threshold A (321) or pulling threshold B (322). When the non-invasive blood glucose measuring device 101 is normally attached, the counted value is a value between the compression threshold A (321) and the pulling threshold B (322), and therefore the error signal 215 (FIG. 9). (F): t93) is not output. In addition, at the output timing (t93) of the error signal 215, the count value of the error detection counter 802 is reset.

  When the feature amount estimation unit 204 detects that the error signal 215 is not output from the error detection unit 803 (t94), the blood sugar level 216 is obtained from the detection signal 213 generated by the photoacoustic detection unit 203, Displayed by the feature amount display means 205.

  FIG. 10 is a diagram showing a timing chart when the non-invasive blood glucose measuring device 101 according to the second embodiment of the present invention is abnormally mounted, that is, when the non-invasive blood glucose measuring device 101 is pressed against the surface 102 of the living body. It is.

  10, (a) is a start signal 212, (b) is a detection signal 213, (c) is a start signal generation counter 206, (d) is a position extraction signal 214, (e) is an error detection counter 802, (f) ) Is an error signal 215.

  Hereinafter, the operation when the noninvasive blood glucose measuring device 101 is pressed against the surface 102 of the living body and mounted will be described with reference to FIGS. 1, 2, 7, and 10.

Here, the following values are set for the respective threshold values. That is,
Compression threshold A (321): Time from turning on the light source 201 detected as an attachment error to the second measurement position Pull threshold B (322): Second after turning on the light source 201 detected as an attachment error Time-out threshold C (323): Time to timeout in measurement from the light source 201 to the second measurement position In-vivo blood vessel threshold E (325): Second measurement position Amplitude position detection threshold value X (221) at ## EQU2 ## The time from when the light source 201 is turned on until the second measurement position is detected is set in advance.

  First, as shown in FIG. 1B, the noninvasive blood glucose measurement device 101 is attached to the surface 102 of a living body such as a patient's arm. Thereafter, when the patient activates a blood glucose level measurement start switch (not shown) provided in the non-invasive blood glucose measuring device 101, the control means 211 outputs a control signal 211 such as the lighting timing of the light source 201, and the light source 201 is turned on. At the same time, an activation signal 212 is output (FIG. 10A: t100).

  Irradiation light 103 from the light source 201 propagates through the living body and is absorbed by glucose in the blood vessel 104 to generate a photoacoustic wave signal 105.

  When the photoacoustic detection unit 203 receives the activation signal 212 from the control unit 202, detection of the photoacoustic wave signal 105 is started, and a detection signal 213 (FIG. 10B) is generated.

  When the start signal generation counter 206 detects the activation signal 212 from the control means 202, the count is started, and the count is continued until the position extraction threshold value X (221) is reached (FIG. 10C). When the value counted by the start signal generation counter 206 becomes equal to or greater than the position extraction threshold value X (221) (t101), the position extraction signal 214 is output to start detection of the second measurement position (FIG. 10 ( d)).

  When the position extraction signal 214 output from the start signal generation counter 206 is detected by the measurement position detection means 801, the second measurement position is detected from the detection signal 213, so that the amplitude of the detection signal 213 and the blood vessel in vivo are detected. The threshold value E (325) is compared. When the amplitude of the detection signal 213 is greater than or equal to the blood vessel threshold E (325) in the living body, the second measurement position (t102) is detected, and the measurement end detection unit 301 outputs a measurement end signal 312. Since the detection of the second measurement position has been described with reference to FIG. 3, the description thereof is omitted here.

  The error detection counter 802 provided in the error detection means 803 starts counting when the position extraction signal 214 from the start signal generation counter 206 is detected, and continues counting until the measurement end signal 312 is detected (FIG. 10 (e)). )). The error detection means 803 compares the value counted by the error detection counter 802 at the output timing of the measurement end signal 312 with a preset compression threshold A (321). When the non-invasive blood sugar measuring device 101 is mounted so as to press the surface of the living body, the counted value becomes a value equal to or smaller than the compression threshold A (321), and therefore the error signal 215 (FIG. 10 (f)). : T103) is output. In addition, at the output timing (t103) of the error signal 215, the count value of the error detection counter 802 is reset.

  When it is detected that the error signal 215 has been output (t104), the error display means 208 notifies the mounting error.

  FIG. 11 is a timing chart when the non-invasive blood glucose measuring device 101 according to the second embodiment of the present invention is abnormally worn, that is, when the surface 102 of the living body is pulled by the non-invasive blood glucose measuring device 101. It is.

  11, (a) is a start signal 212, (b) is a detection signal 213, (c) is a start signal generation counter 206, (d) is a position extraction signal 214, (e) is an error detection counter 802, (f ) Is an error signal 215.

  Hereinafter, the operation when the surface 102 of the living body is pulled by the non-invasive blood glucose measurement device 101 will be described with reference to FIGS. 1, 2, 7, and 11.

Here, the following values are set for the respective threshold values. That is,
Compression threshold A (321): Time from turning on the light source 201 detected as an attachment error to the second measurement position Pull threshold B (322): Second after turning on the light source 201 detected as an attachment error Time-out threshold C (323): Time to timeout in measurement from the light source 201 to the second measurement position In-vivo blood vessel threshold E (325): Second measurement position Amplitude position detection threshold value X (221) at ## EQU2 ## The time from when the light source 201 is turned on until the second measurement position is detected is set in advance.

  First, as shown in FIG. 1C, the noninvasive blood glucose measurement device 101 is attached to the surface 102 of a living body such as a patient's arm. Thereafter, when the patient activates a blood glucose level measurement start switch (not shown) provided in the non-invasive blood glucose measuring device 101, the control means 211 outputs a control signal 211 such as the lighting timing of the light source 201, and the light source 201 is turned on. At the same time, an activation signal 212 is output (FIG. 11 (a): t110).

  Irradiation light 103 from the light source 201 propagates through the living body and is absorbed by glucose in the blood vessel 104 to generate a photoacoustic wave signal 105.

  When the photoacoustic detection unit 203 receives the activation signal 212 from the control unit 202, detection of the photoacoustic wave signal 105 is started, and a detection signal 213 (FIG. 11B) is generated.

  When the start signal generation counter 206 detects the activation signal 212 from the control means 202, the count is started, and the count is continued until the position extraction threshold value X (221) is reached (FIG. 11 (c)). When the value counted by the start signal generation counter 206 becomes equal to or greater than the position extraction threshold X (221) (t111), the position extraction signal 214 is output to start detection of the second measurement position (FIG. 11 ( d)).

  When the position extraction signal 214 output from the start signal generation counter 206 is detected by the measurement position detection means 801, the second measurement position is detected from the detection signal 213, so that the amplitude of the detection signal 213 and the blood vessel in vivo are detected. The threshold value E (325) is compared. When the amplitude of the detection signal 213 is equal to or greater than the blood vessel threshold E (325) in the living body, the second measurement position (t112) is detected and the measurement end signal 312 is output. Since the detection of the second measurement position has been described with reference to FIG. 3, the description thereof is omitted here.

  When the position detection signal 214 from the start signal generation counter 206 is detected by the error detection counter 802 provided in the error detection means 803, the count is started and continues until the measurement end signal 312 is detected (FIG. 11 (e)). )). The error detection means 803 compares the value counted by the error detection counter 802 at the output timing of the measurement end signal 312 with a preset pulling threshold B (322). When the non-invasive blood glucose measuring device 101 is mounted so as to pull the surface of the living body, the counted value becomes a value equal to or larger than the pulling threshold B (322), and therefore the error signal 215 (FIG. 11 (f): t113) is output. In addition, at the output timing (t113) of the error signal 215, the count value of the error detection counter 802 is reset.

  When it is detected that the error signal 215 is output (t114), the error display means 208 notifies the mounting error.

  As described above, according to the second embodiment of the present invention, by providing the mounting confirmation unit 207, the second measurement position is detected from when the second measurement position is detected from the detection signal 213 and the light source 201 is turned on. Whether or not there is a mounting error due to the measurement operation of the non-invasive blood glucose measurement device by measuring the time until detection of this and determining whether it corresponds to the time when it is normally mounted by comparing with a threshold value This makes it possible to detect a mounting error without increasing the size of the noninvasive blood glucose measurement device, and prevents the patient from administering insulin based on an incorrect blood glucose level. Can do.

  In the second embodiment of the present invention, the blood vessel threshold E (325) in the living body has been described as the amplitude of the detection signal 213 at the second measurement position, but the detection signal 213 at the second measurement position. A similar result can be obtained.

  In Embodiment 2 of the present invention, the low-pass filter 304 is provided in the measurement position detection unit 801. However, in order to remove the influence of disturbance, the low-pass filter 304 is provided in the photoacoustic detection unit 203 and the noise of the detection signal 213. Components may be removed, and similar effects can be obtained.

  Furthermore, in the second embodiment of the present invention, the measurement position detection unit 801 detects a position where the detection signal changes from a value higher than the blood vessel threshold value E in the living body as a second measurement position. However, the peak position extraction unit 305 in the measurement position detection unit 801 determines the second position where the difference between the detection signal 213 and the in-vivo blood vessel threshold E (325) is the largest during the period when the measurement end signal 312 is valid. The time of the second measurement peak position may be counted from when the error detection counter 802 detects the position extraction signal 214 from the start signal generation counter 206 with the error detection counter 802. Obtainable.

  Furthermore, in the second embodiment of the present invention, the time of the second measurement position is counted from when the error detection counter 802 detects the position extraction signal 214 from the start signal generation counter 206. However, the measurement position detection means 801 The second measurement position is detected by the peak position extraction means 305 during the period when the measurement end signal 312 is valid, and the time of the second measurement position is counted from when the light source 201 is turned on by the error detection counter 802. However, the same effect can be obtained.

  As described above, the noninvasive living body information measuring apparatus according to the present invention is provided with the attachment confirmation means in the noninvasive living body information measuring apparatus, and is appropriately mounted on the surface of the living body by the measurement operation of the noninvasive living body information measuring apparatus. Therefore, when the non-invasive biological information measuring device is a non-invasive blood glucose measuring device, the patient can be detected based on an incorrect blood glucose level. This is useful for preventing insulin administration.

(A) The figure which shows the state in case the mounting | wearing of the noninvasive blood glucose measuring device 101 in Embodiment 1 and Embodiment 2 of this invention is normal, (b) In Embodiment 1 and Embodiment 2 of this invention The figure which shows a state in case the mounting | wearing of the noninvasive blood glucose measuring device 101 is abnormal (it is pressed on the surface 102 of a biological body), (c) The noninvasive blood glucose measuring device in Embodiment 1 and Embodiment 2 of this invention The figure which shows the state when mounting | wearing of 101 is abnormal (the surface 102 of the biological body is pulled) The figure which shows the block structure of the noninvasive blood-glucose measuring device 101 in Embodiment 1 and Embodiment 2 of this invention. The figure which shows the block structure of the installation confirmation means 207 in Embodiment 1 of this invention. Waveform diagram showing the detailed operation of the measurement position detecting means 301 in Embodiment 1 of the present invention The figure which shows the timing chart in case the mounting | wearing of the noninvasive blood glucose measuring device 101 in Embodiment 1 of this invention is normal. The figure which shows the timing chart when mounting | wearing of the noninvasive blood glucose measuring device 101 in Embodiment 1 of this invention is abnormal (it is pressed on the surface 102 of a biological body). The figure which shows the timing chart when mounting | wearing of the noninvasive blood glucose measuring device 101 in Embodiment 1 of this invention is abnormal (the surface 102 of the biological body is pulled). The figure which shows the block configuration of the installation confirmation means 207 in Embodiment 2 of this invention. The figure which shows the timing chart in case the mounting | wearing of the noninvasive blood glucose measuring device 101 in Embodiment 2 of this invention is normal. The figure which shows the timing chart when mounting | wearing of the noninvasive blood glucose measuring device 101 in Embodiment 2 of this invention is abnormal (it is pressed on the surface 102 of a biological body). The figure which shows the timing chart when mounting | wearing of the noninvasive blood glucose measuring device 101 in Embodiment 2 of this invention is abnormal (the surface 102 of the biological body is pulled).

Explanation of symbols

DESCRIPTION OF SYMBOLS 101 Noninvasive blood glucose measuring device 102 Living body surface 103 Irradiation light 104 Blood vessel 105 Photoacoustic wave signal 201 Light source 202 Control means 203 Photoacoustic detection means 204 Feature quantity estimation means 205 Feature quantity display means 206 Start signal generation counter 207 Attachment confirmation means 208 Error display means 211 Control signal 212 Start signal 213 Detection signal 214 Position extraction signal 215 Error signal 216 Blood glucose level 221 Position extraction threshold X
301 Measurement position detection means 302 Error detection counter 303 Error detection means 304 Low pass filter 305 Peak position extraction means 311 Measurement start signal 312 Measurement end signal 321 Compression threshold A
322 Pulling threshold B
323 Timeout threshold C
324 Biological surface threshold D
325 Blood vessel threshold E
326 Invalid time threshold value before LPF start 327 Invalid time threshold value after LPF start 328 Invalid time threshold value before LPF end 329 Invalid time threshold value after LPF end 801 Measurement position detection means 802 Error detection counter 803 Error detection means

Claims (49)

In a non-invasive living body information measuring apparatus for detecting a photoacoustic wave signal from within the living body that includes a feature amount of living body information by irradiating the surface of the living body from the surface of the living body,
At least one light source;
Control means for controlling the lighting timing of the light source and outputting an activation signal;
A photoacoustic detection means for detecting a photoacoustic wave signal from the living body by irradiation light of the light source based on the activation signal, and generating a detection signal;
Feature quantity estimation means for estimating the feature quantity of biological information from the detection signal generated by the photoacoustic detection means;
Feature quantity display means for displaying the feature quantity of the biological information estimated by the feature quantity estimation means;
Based on the detection signal generated by the photoacoustic detection means, the distance between the surface of the living body and the blood vessel in the living body is measured, and whether or not the noninvasive living body information measuring device is correctly attached to the living body according to the distance. Installation confirmation means to confirm;
An error display means for notifying a user of an error signal output from the mounting confirmation means,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 1,
The mounting confirmation means includes
A first measurement position and a second measurement position are detected from the detection signal, a distance between the first and second measurement positions is measured, and the living body is compressed by a non-invasive living body information measuring device. A threshold value for compression A or lower, which is a criterion for determining whether or not the wearing state is applied, a threshold value for pulling B or higher, which is a criterion for determining whether or not the living body is pulled by the noninvasive biological information measuring device, or When the measurement of the distance between the first and second measurement positions is not less than a timeout threshold C, which is a criterion for determining whether or not a timeout occurs, it is an error to attach the noninvasive living body information measuring device to the living body. Output the error signal to the effect,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 1,
The mounting confirmation means includes
A measurement start signal for detecting the first and second measurement positions based on the detection signal output from the photoacoustic detection means and indicating the start and end of measurement of the distance between the first and second measurement positions; A measurement position detecting means for outputting a measurement end signal;
It has an error detection counter that starts counting based on the measurement start signal and ends counting based on the measurement end signal, and outputs the error signal by comparing the value counted by the error detection counter with a threshold value. Having an error detection means,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 3,
The threshold value that the error detection means compares with the value counted by the error detection counter is:
A threshold A for compression, which is a criterion for determining whether or not the living body is in a state of being pressed by the noninvasive living body information measuring device;
A pulling threshold B that is a criterion for determining whether or not the living body is pulled by the noninvasive living body information measuring device;
A timeout threshold C, which is a criterion for determining whether or not the measurement of the distance between the first and second measurement positions results in a timeout;
The error detection means outputs the error signal when a value counted by the error detection counter is not more than the compression threshold A, or not less than the pulling threshold B, or not less than the timeout threshold C.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 3,
The measurement position detecting means includes
Comparing the detection signal output from the photoacoustic detection means with a threshold value D for the surface of the living body, which is a criterion for determining whether the detection signal corresponds to a photoacoustic signal whose energy has been converted on the surface of the living body. And detecting the first measurement position and starting to output a measurement start signal indicating the start of measurement of the distance between the first and second measurement positions,
Thereafter, a detection signal output from the photoacoustic detection means and a threshold value E for the blood vessel in the living body, which is a criterion for determining whether or not the detection signal corresponds to a photoacoustic signal energy-converted in the blood vessel in the living body. Detecting the second measurement position by comparing and starting outputting a measurement end signal indicating the end of measurement of the distance between the first and second measurement positions;
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 5,
The position where the detection signal output from the photoacoustic detection means changes from a value higher than the threshold value D for the surface of the living body to a lower value is detected as the first measurement position, and the output of the measurement start signal is started. ,
Terminates the output of the measurement start signal at a position where the detection signal changes from a lower value to a higher value than the surface threshold D for the living body,
Thereafter, the position where the detection signal changes from a value higher than the blood vessel threshold E in the living body to a lower value is detected as the second measurement position, and the output of the measurement end signal is started.
Ending the output of the measurement end signal at a position where the detection signal changes from a lower value to a higher value than the blood vessel threshold value E in the living body,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 3,
The measurement position detection means has a low-pass filter,
The low-pass filter can invalidate the measurement start signal and the measurement end signal when the output time of the measurement start signal and the measurement end signal is short.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 7,
The low-pass filter has a plurality of externally writable registers,
By changing the value written to the register, it is possible to change the time for invalidating the measurement start signal and the measurement end signal.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 5,
The measurement position detection means has a peak position extraction means,
The peak position extraction means compares the detection signal with the living body surface threshold D, and detects the position where the difference between the detection signal and the living body surface threshold D is the largest as the first measurement position. Then, the detection signal is compared with the blood vessel threshold value E in the living body, and the position where the difference between the detection signal and the blood vessel threshold value E in the living body is the largest is detected as the second measurement position. ,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 2,
The first measurement position detected by the mounting confirmation means is:
The position corresponding to the detection signal generated from the photoacoustic wave signal from the surface of the living body,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 2,
The second measurement position detected by the mounting confirmation means is:
A position corresponding to a detection signal generated from a photoacoustic wave signal from a blood vessel in the living body,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 5,
The biological surface threshold D and the biological blood vessel threshold E that the measurement position detection means compares with the detection signal are:
Each is a predetermined amplitude value for the detection signal,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 5,
The biological surface threshold D and the biological blood vessel threshold E that the measurement position detection means compares with the detection signal generated by the photoacoustic detection means are:
Each is a value of a predetermined slope with respect to the detection signal,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 5,
The measurement position detecting means has a plurality of externally writable registers,
It is possible to change the threshold value D for the surface of the living body and the threshold value E for the blood vessel in the living body by changing the value written in the register.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 3,
The error signal output by the error detection means is
The photoacoustic detection means is output as a result of detecting pressure or tension on the surface of the living body.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 3,
The error detection means has a plurality of externally writable registers,
It is possible to change the threshold value for compression A, the threshold value for pulling B, and the threshold value for timeout C by changing the value written to the register.
A noninvasive living body information measuring device characterized by the above. In a non-invasive living body information measuring apparatus for detecting a photoacoustic wave signal from within the living body that includes a feature amount of living body information by irradiating light on the surface of the living body from the surface of the living body,
At least one light source;
Control means for controlling the lighting timing of the light source and outputting an activation signal;
A photoacoustic detection means for detecting a photoacoustic wave signal from the living body by irradiation light of the light source based on the activation signal, and generating a detection signal;
Feature quantity estimation means for estimating the feature quantity of biological information from the detection signal generated by the photoacoustic detection means;
Feature quantity display means for displaying the feature quantity estimated by the feature quantity estimation means;
A start signal generation counter that starts counting based on the activation signal and outputs a position extraction signal when the counted value is equal to or greater than a position extraction threshold value X that is a criterion for starting position measurement;
By receiving the position extraction signal, the distance between the surface of the living body and the blood vessel in the living body is measured based on the detection signal generated by the photoacoustic detection means, and a non-invasive living body information measuring device is provided according to the distance. An attachment confirmation means for confirming whether or not it is correctly attached to the living body;
An error display means for notifying a user of an error signal output from the mounting confirmation means,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 17,
The mounting confirmation means includes
A first measurement position and a second measurement position are detected from the detection signal, a distance between the first and second measurement positions is measured, and the living body is compressed by a non-invasive living body information measuring device. A threshold value for compression A or lower, which is a criterion for determining whether or not the wearing state is applied, a threshold value for pulling B or higher, which is a criterion for determining whether or not the living body is pulled by the noninvasive biological information measuring device, or When the measurement of the distance between the first and second measurement positions is greater than or equal to a timeout threshold C, which is a criterion for determining whether or not a timeout occurs, the attachment of the photoacoustic detection means to the living body is an error. Outputting the error signal;
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 17,
The mounting confirmation means includes
A measurement start signal for detecting the first and second measurement positions based on the detection signal output from the photoacoustic detection means and indicating the start and end of measurement of the distance between the first and second measurement positions; A measurement position detecting means for outputting a measurement end signal;
It has an error detection counter that starts counting based on the measurement start signal and ends counting based on the measurement end signal, and outputs the error signal by comparing the value counted by the error detection counter with a threshold value. Having an error detection means,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 19,
The threshold value that the error detection means compares with the value counted by the error detection counter is:
A threshold A for compression, which is a criterion for determining whether or not the living body is in a state of being pressed by the noninvasive living body information measuring device;
A pulling threshold B that is a criterion for determining whether or not the living body is pulled by the noninvasive living body information measuring device;
A timeout threshold C, which is a criterion for determining whether or not the measurement of the distance between the first and second measurement positions results in a timeout;
The error detection means outputs the error signal when a value counted by the error detection counter is not more than the compression threshold A, or not less than the pulling threshold B, or not less than the timeout threshold C.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 19,
The measurement position detecting means includes
Comparing the detection signal output from the photoacoustic detection means with a threshold value D for the surface of the living body, which is a criterion for determining whether the detection signal corresponds to a photoacoustic signal whose energy has been converted on the surface of the living body. And detecting the first measurement position and starting to output a measurement start signal indicating the start of measurement of the distance between the first and second measurement positions,
Thereafter, a detection signal output from the photoacoustic detection means and a threshold value E for the blood vessel in the living body, which is a criterion for determining whether or not the detection signal corresponds to a photoacoustic signal energy-converted in the blood vessel in the living body. Detecting the second measurement position by comparing and starting outputting a measurement end signal indicating the end of measurement of the distance between the first and second measurement positions;
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 21,
The position where the detection signal output from the photoacoustic detection means changes from a value higher than the threshold value D for the surface of the living body to a lower value is detected as the first measurement position, and the output of the measurement start signal is started. ,
Terminates the output of the measurement start signal at a position where the detection signal changes from a lower value to a higher value than the surface threshold D for the living body,
Thereafter, the position where the detection signal changes from a value higher than the blood vessel threshold E in the living body to a lower value is detected as the second measurement position, and the output of the measurement end signal is started.
Ending the output of the measurement end signal at a position where the detection signal output from the photoacoustic detection means changes from a value lower than the blood vessel threshold E in the living body to a higher value,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 19,
The measurement position detection means has a low-pass filter,
The low-pass filter can invalidate the measurement start signal and the measurement end signal when the output time of the measurement start signal and the measurement end signal is short.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 22,
The low-pass filter has a plurality of externally writable registers,
By changing the value written to the register, it is possible to change the time for invalidating the measurement start signal and the measurement end signal.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 21,
The measurement position detection means has a peak position extraction means,
The peak position extraction means compares the detection signal with the living body surface threshold D, and detects the position where the difference between the detection signal and the living body surface threshold D is the largest as the first measurement position. Then, the detection signal is compared with the blood vessel threshold value E in the living body, and the position where the difference between the detection signal and the blood vessel threshold value E in the living body is the largest is detected as the second measurement position. ,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 17,
The first measurement position detected by the mounting confirmation means is:
The position corresponding to the detection signal generated from the photoacoustic wave signal from the surface of the living body,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 17,
The second measurement position detected by the mounting confirmation means is:
A position corresponding to a detection signal generated from a photoacoustic wave signal from a blood vessel in the living body,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 21,
The biological surface threshold D and the biological blood vessel threshold E that the measurement position detection means compares with the detection signal are:
Each is a predetermined amplitude value for the detection signal,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 21,
The biological surface threshold D and the biological blood vessel threshold E that the measurement position detection means compares with the detection signal generated by the photoacoustic detection means are:
Each is a value of a predetermined slope with respect to the detection signal,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 21,
The measurement position detecting means has a plurality of externally writable registers,
It is possible to change the threshold value D for the surface of the living body and the threshold value E for the blood vessel in the living body by changing the value written in the register.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 19,
The error signal output by the error detection means is
The photoacoustic detection means is output as a result of detecting pressure or tension on the surface of the living body.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 20,
The error detection means has a plurality of externally writable registers,
It is possible to change the threshold A for compression, the threshold B for pulling, and the threshold C for time-out C by changing the value written to the register.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 17,
The start signal generation counter has a register writable from the outside,
It is possible to change the position extraction threshold value X by changing the value written to the register.
A noninvasive living body information measuring device characterized by the above. In a non-invasive living body information measuring apparatus for detecting a photoacoustic wave signal from within the living body that includes a feature amount of living body information by irradiating light on the surface of the living body from the surface of the living body,
At least one light source;
Control means for controlling the lighting timing of the light source and outputting an activation signal;
A photoacoustic detection means for detecting a photoacoustic wave signal from the living body by irradiation light of the light source based on the activation signal, and generating a detection signal;
Feature quantity estimation means for estimating the feature quantity of biological information from the detection signal generated by the photoacoustic detection means;
Feature quantity display means for displaying the feature quantity estimated by the feature quantity estimation means;
A start signal generation counter that starts counting based on the activation signal and outputs a position extraction signal when the counted value is equal to or greater than a position extraction threshold value X that is a criterion for starting position measurement;
By receiving the position extraction signal, the second measurement position of the detection signal generated by the photoacoustic detection means is detected, and the distance from the output timing of the position extraction signal to the second measurement position is measured. Mounting confirmation means for confirming whether or not the non-invasive living body information measuring device is correctly mounted on the living body according to the distance;
An error display means for notifying a user of an error signal output from the mounting confirmation means,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 34,
The mounting confirmation means includes
A second measurement position is detected from the detection signal, an output timing of the position detection signal and a distance between the second measurement positions are measured, and the living body is compressed by the noninvasive living body information measuring device. The threshold value for compression A or lower, which is a criterion for determining whether or not the wearer is in the worn state, the threshold value for pulling B that is a criterion for determining whether or not the living body is pulled by the noninvasive living body information measuring device, or the position When the measurement of the distance between the output timing of the extraction signal and the second measurement position is a time-out threshold C that is a criterion for determining whether or not a time-out occurs, the photoacoustic detection means is attached to the living body in error. Output the error signal to the effect,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 34,
The mounting confirmation means includes
The second measurement position is detected based on the detection signal output from the photoacoustic detection means, and a measurement end signal indicating the end of measurement of the output timing of the position extraction signal and the distance between the second measurement positions is output. Measuring position detecting means,
An error detection counter that starts counting at the output timing of the position extraction signal and ends counting based on the measurement end signal, and compares the value counted by the error detection counter with a threshold value to determine the error signal. Error detection means for outputting,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 36,
The threshold value that the error detection means compares with the value counted by the error detection counter is:
A threshold A for compression, which is a criterion for determining whether or not the living body is in a state of being pressed by the noninvasive living body information measuring device;
A pulling threshold B that is a criterion for determining whether or not the living body is pulled by the noninvasive living body information measuring device;
A timeout threshold C which is a criterion for determining whether or not the measurement of the distance from the output timing of the position extraction signal to the second measurement position times out,
The error detection means outputs the error signal when a value counted by the error detection counter is not more than the compression threshold A, or not less than the pulling threshold B, or not less than the timeout threshold C.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 36,
The measurement position detecting means includes
Based on the position extraction signal, a detection signal output from the photoacoustic detection means and a blood vessel in the living body that is a criterion for determining whether or not the detection signal corresponds to a photoacoustic signal energy-converted in the blood vessel in the living body The second measurement position is detected by comparing with a threshold value E, and the output of a measurement end signal indicating the end of measurement of the distance between the output timing of the position extraction signal and the second measurement position is started.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 38,
Detecting a position where the detection signal output from the photoacoustic detection means changes from a value higher than the blood vessel threshold E in the living body to a lower value as the second measurement position;
Ending the output of the measurement end signal at a position where the detection signal output from the photoacoustic detection means changes from a value lower than the blood vessel threshold E in the living body to a higher value,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 36,
The measurement position detection means has a low-pass filter,
The low-pass filter can invalidate the measurement end signal when the output time of the measurement end signal is short.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 40,
The low-pass filter has a register writable from the outside,
It is possible to change the time for invalidating the measurement end signal by changing the value of the register.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 38,
The measurement position detection means has a peak position extraction means,
The peak position extracting means compares the detection signal with the blood vessel threshold value E in the living body, and determines the position where the difference between the detection signal and the blood vessel threshold value E in the living body is the largest as the second measurement position. Detect as,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 38,
The second measurement position measured by the mounting confirmation means is:
A position corresponding to a detection signal generated from a photoacoustic wave signal from a blood vessel in the living body,
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 38,
The in-vivo blood vessel threshold value E that the measurement position detection means compares with the detection signal is:
A predetermined amplitude value for the detection signal;
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 38,
The in-vivo blood vessel threshold value E that the measurement position detection means compares with the detection signal is:
A value of a predetermined inclination with respect to the detection signal;
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 36,
The measurement position detection means has a register writable from the outside,
By changing the value to be written to the register, it is possible to change the blood vessel threshold E in the living body.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 36,
The error signal output by the error detection means is
The photoacoustic detection means is output as a result of detecting pressure or tension on the surface of the living body.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 37,
The error detection means has a plurality of externally writable registers,
It is possible to change the threshold value for compression A, the threshold value for pulling B, and the threshold value for timeout C by changing the value written to the register.
A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 34,
The start signal generation counter has a register writable from the outside,
It is possible to change the position extraction threshold value X by changing the value written to the register.
A noninvasive living body information measuring device characterized by the above.

Images