JP2009046391A - Pharmaceutical preparation for improving and treating cachexia and food preparation having cachexia-improving action - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a pharmaceutical preparation for improving and treating cachexia in diseases such as cancer and tumor, diabetes, endocrine diseases, haematologic diseases and tuberculosis, and to provide a food preparation. <P>SOLUTION: The pharmaceutical preparation for improving and treating the cachexia and the food preparation each contains Sapium sebiferum (L.) Roxb. and/or its extract as an active ingredient. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a cachexia-improving therapeutic preparation and a food preparation having a cachexia-improving action in diseases such as cancer and tumor, diabetes, endocrine disease, blood system disease, tuberculosis and the like.

  When diseases such as cancer and tumor, diabetes, endocrine disease, blood system disease, tuberculosis worsen, symptoms such as generalized weakness, malaise, loss of appetite, irritability (extreme skinnyness), complexion, paleness, inability to act Get up. It has a characteristic facial appearance (cachexia), such as facial edema or lower leg edema, dry and loose skin, and dents in the eyes and cheeks. Such a condition refers to “cachexia”. Cachexia is considered to be a pathological condition caused by various metabolic abnormalities including proteins and toxohormones. Cachexia causes an extreme decrease in patient quality of life (QOL).

  Biochemically, electrolyte abnormalities (eg, hypercalcemia), tumor necrosis factor-α (TNF-α), interleukin-6 (interleukin, IL-6), interferon (IFN); ), An increase in the content of physiologically active substances such as toxohormones.

  Improving cachexia (especially malaise, loss of appetite, and anxiety) empowers patients to perform daily behavior, reduces mental distress for patients and their families, improves quality of survival, and clinically However, it has a great social significance.

  Until now, there is only a symptomatic treatment method for cachexia, and there is no effective treatment method. Drugs that are used symptomatically in Japan are purinperan as the first choice, hystron H as the second choice, and steroids as the third choice (Non-patent Document 1, Non-patent Document 2, Non-patent Document 3). However, all these drugs have strong side effects. Patients who have progressed to cachexia are no longer able to withstand the side effects of these drugs.

  In recent years, therefore, research has been conducted on anti-cachexia effects in natural medicinal plants. So far, natural medicinal plants that are effective in improving cachexia are Huang Ren (Non-patent Document 4), Ginseng (Non-patent Document 5), Juzen Daihoto (Medical Ginseng, Bukkyou, Sandalwood, Licorice, Toki) , Peony, nematode, diau, nikki, and a mixture of 10 kinds of herbal medicines, non-patent document 6) and the like.

  However, these plants showed improvements in biochemical indicators (TNF-α, IFN, IL-6, etc.) on the data, but the clinical effect was too thin, and a satisfactory effect was obtained. I can't.

  Therefore, the present invention examined the action of the plant Nankin goby (Patent Document 1), which has been recognized as having an anticancer action, in improving cachexia.

Japanese Patent Application No. 2004-364329. Tetsuo Kashiwagi, “Palliative Medicine”, 1997, Miwa Shoten, Tokyo. World Health Organization, "Release from end-stage symptoms", 2000, Medical School, Tokyo. Makoto Yamamuro, “Palliative Care Text”, 2002: Chugai Medical, Tokyo. Norio Iizuka et al., “Examination of the effect of Coptidis rhizoma on cancer cachexia”, Vol. 15, no. 3, p. 354, 2001, Biotherapy. Toru Sugiyama et al., “Chinese Medicine and Traditional Chinese Medicine, Kampo Medicine in Gynecological Cancer Treatment”, Vol. 48, no. 3, p. 153-157, 2002, cancer clinical. Masanori Takahashi, “Effects of Juzentaihoto (TJ-48) on Anorexia in the End Stage of Gastrointestinal Cancer—Relationship with the Appetite Related Hormone Ghrelin”, Vol. 24, no. 11, p. 2742-3, 2004, Prog Med.

  An object of the present invention is to provide a cachexia-improving therapeutic preparation and a food preparation thereof that have a remarkable clinical effect on cachexia and that have no side effects.

  Furthermore, an object of the present invention is to provide an effective prophylactic preparation and food preparation so that patients with cancer and tumor, diabetes, endocrine disease, blood system disease, tuberculosis and the like do not become cachexia.

  It has been found that the present invention has an excellent cachexia-improving action of peanut.

  The cachexia-improving therapeutic preparation of the present invention contains nankin goby or an extract thereof as an active ingredient.

  The cachexia prevention and improvement food preparation of the present invention contains peanut or a extract thereof as an active ingredient.

  In the present invention, “cancer” means a carcinoma derived from epithelial cells, a sarcoma derived from non-epithelial cells such as bones and muscles, and a gland originating from secretory tissue. Cancer (adenomas), lymphoma originating from lymphoid tissue (lymphoma), melanoma arising from melanocyte, melanoma arising in germ cell tissue, hematopoiesis due to tumorigenicity of hematopoietic cells It refers to brain tumors that are organ tumors or neuroepithelial tumors.

  Further, in the present invention, “a extract of peanut” refers to an extract extracted from a peanut with a solvent or a dried product of this extract.

  According to the cachexia improving therapeutic agent of the present invention, there are no serious side effects by containing nankin goby and / or its extract as an active ingredient, cancer and tumor, diabetes, endocrine disease, blood system disease, tuberculosis. The patient's cachexia condition can be improved. Therefore, the cachexia improving therapeutic preparation of the present invention is useful, for example, as a cachexia improving preparation and / or a therapeutic preparation thereof, and / or a food preparation thereof, and / or a functional food preparation thereof. According to the preparation of the present invention, cachexia of end-stage patients can be improved and QOL can be improved.

  The cachexia-improving therapeutic preparation and / or cachexia-preventing preparation and food preparation thereof (hereinafter also referred to as “composition”) of the present invention contain peanut and / or an extract thereof as active ingredients.

  According to the composition of the present invention, the cachexia-improving action can prevent diseases such as cancer and tumor, diabetes, endocrine disease, blood system disease, tuberculosis from progressing to the cachexia state. , And can improve and treat cachexia.

  The composition of the present invention is useful, for example, as an active ingredient of a cachexia ameliorating therapeutic preparation and a food preparation thereof. The composition of the present invention is very useful in that it has an excellent cachexia improving effect and has no serious side effects. Hereinafter, the method of the present invention will be specifically described.

1. Euphorbiaceae Sapium plant used as a raw material in the composition of the present invention is a deciduous or evergreen shrub or tree. Plants of the genus Sapium are distributed in tropics and subtropics such as Southeast Asia and Central and South America. An example of a plant belonging to the genus Sapium of the Euphorbiaceae family is peanut.

  When a plant belonging to the genus Sapium is used as a raw material of the present invention, its use site is not particularly limited. For example, fruit, stem, root, root bark, flower, seed, bark, resin, trunk, xylem, branch Etc. can be used. It can also be used with various parts such as the trunk or root epidermis, soft tissue, endothelium, xylem, and sieve. These materials may be either wet or dry. Moreover, you may use the extract obtained by drying the extract extracted with the solvent, or this extract.

  Although it does not specifically limit as a kind of solvent for extraction, For example, water, a hydrophilic organic solvent, and a lipophilic organic solvent are mentioned. Examples of the hydrophilic organic solvent include lower alcohols such as methanol, ethanol, propanol and butanol, organic acids such as formic acid and acetic acid, dimethyl sulfoxide and phenols. Among these, water or ethanol is preferable in that it is used for food. Examples of the lipophilic organic solvent include chloroform, pentane, hexane, acetone, ethyl acetate, acetonitrile, benzene, and vegetable oils such as rapeseed oil.

名：Ｖｅｇｅｔａｂｌｅ ｔａｌｌｏｗ、または、Ｃｈｉｎｅｓｅ ｔａｌｌｏｗ ｔｒｅｅ、または、Ｔａｌｌｏｗ ｔｒｅｅ、または、ｗｈｉｔｅ ｗａｘ ｂｅｒｒｙ、または、ｃｈｉｃｋｅｎ ｔｒｅｅ、または、ｐｏｐｃｏｒｎ ｔｒｅｅ）は、中国原産のトウダイグサ科サピウム属落葉高木で、秋には菓が美しい赤紅色に色づき、街路樹や庭園樹として植栽されている。日本では、その乾燥根皮は利尿剤または下剤として利用され、その種子は蝋燭や石鹸の原料として利用されている。Nankin goby (Nanjing Huangpu, Scientific name: Sapium sebiferum (L.) Roxb.,

Name: Vegetable tall, Chinese tall tree, Tallow tree, white wax very, chicken tree, or popcorn tree Colored in beautiful red and red, it is planted as street trees and garden trees. In Japan, the dried root bark is used as a diuretic or laxative, and its seed is used as a raw material for candles and soaps.

  When peanut is used as a raw material of the composition of the present invention, the use site is not particularly limited. For example, root bark, root, stem, seed, fruit, leaf, flower, bark, resin, trunk, xylem, branch Can be used. It can also be used with various parts such as the trunk or root epidermis, soft tissue, endothelium, xylem, and sieve. Further, as a raw material of the composition of the present invention, an extract extracted from a groundnut with a solvent or a dried product obtained by drying the extract may be used. When humans ingest peanut and / or its extract, diarrhea may occur, but it will recover after about half a day. There are no other side effects and no toxicity.

  The method for producing the extract of peanut (the extraction method of the active ingredient) is not particularly limited. For example, a fresh root bark or dried root bark of peanut is soaked in distilled water, and the temperature is low for several minutes to several tens of hours. The method of leaving still above is mentioned. Examples of other methods for producing the extract include a hot water extraction method and a solvent extraction method.

2. Evaluation method of cachexia improving action As an evaluation of cachexia improving action in the composition of the present invention, a known method for evaluating humans and an evaluation method for cancer-bearing animal models are used. be able to. As evaluation methods for human subjects, there are an evaluation method based on clinical indicators and an evaluation method based on biochemical indicators.

  Although it does not necessarily limit as a clinical parameter | index, Symptoms, such as anorexia, a malaise, a tingle, a weight loss, are often used mainly (nonpatent literature 6).

  Biochemical indicators include, but are not limited to, TNF-α, IFN, and IL-6.

  In addition, plasma calcium concentration and blood glucose level may be used as evaluation indexes.

  In the present invention, first, humans were evaluated from clinical indices.

  As diseases such as cancer and tumor, diabetes, endocrine disease, blood system disease, tuberculosis progress, various types such as TNF-α, IFN, IL-6, including toxohormones in body fluids, especially blood Cytokines increase, appetite-related hormones (ghrelin, leptin) decrease, and anorexia occurs. In addition, an increase in feeding inhibitory neuron activity in the hypothalamus, a decrease in feeding promoting neuron activity, and suppression of gastric motility and secretory function through the vagus nerve pathway also cause anorexia.

  Loss of appetite causes weight loss, tingling, malaise, and thus a decrease in daily behavioral ability.

  Improvement of appetite and weight gain, recovery of daily behavioral ability are evaluated as improvement of cachexia or escape from cachexia (healing).

3. Applications related to cachexia-improving action Cancers are roughly classified into hematopoietic cancer, carcinoma composed of epithelial cells, and sarcoma composed of non-epithelial cells. Examples of hematopoietic cancer are leukemia, malignant lymphoma, myeloma, and the like. Examples of the cancer derived from epithelial cells include lung cancer, breast cancer, stomach cancer, colon cancer, uterine cancer, ovarian cancer, head and neck cancer (laryngeal cancer, pharyngeal cancer, tongue cancer, etc.) and the like. Examples of the sarcoma include osteosarcoma, chondrosarcoma, rhabdomyosarcoma, leiomyosarcoma, fibrosarcoma, liposarcoma, and angiosarcoma.

  The composition of the present invention can exert an anti-cachexia effect on any terminal cancer. That is, examples of terminal cancers to which the composition of the present invention is applied include malignant lymphoma (Hodgkin lymphoma, non-Hodgkin lymphoma, etc.), gastric cancer, penile cancer, pharyngeal cancer (nasopharyngeal cancer, oropharyngeal cancer). , Hypopharyngeal canal, etc.), vulvar cancer, pituitary fibroma, hepatocellular carcinoma, thymoma, mycosis fungoides, cancer of unknown primary origin, myelodysplastic syndrome, uterine cancer (cervical cancer, uterine body) Cancer, uterine sarcoma), chorionic disease, esophageal cancer, renal pelvic cancer, ureteral cancer, glioma, renal cell cancer, pancreatic cancer, pancreatic endocrine tumor, testicular tumor, prostate cancer , Colorectal cancer, multiple myeloma, bile duct cancer, gallbladder cancer, vaginal cancer, mesothelioma, acoustic schwannoma, soft tissue sarcoma, breast cancer, brain tumor, lung cancer, leukemia (acute myeloid leukemia, acute lymphoblastic leukemia) Adult T-cell leukemia / lymphoma, chronic myeloid leukemia, chronic lymphocytic leukemia) (Malignant melanoma, etc.), bladder cancer, chronic myeloproliferative diseases, ovarian cancer, ovarian germ cell tumor.

  Furthermore, it can exert an anti-cachexia effect even in the cachexia state of diseases such as diabetes, endocrine disease, blood system disease, tuberculosis and the like.

  When the composition of the present invention is used as a cachexia improving therapeutic preparation, it can be used in combination with other anticancer agents. In this case, the composition of the present invention can be used in combination with interferons or cytokines that enhance the immune function.

  Furthermore, the composition of the present invention is used in combination with other anticancer agents such as cisplatin, carboplatin, oxaloplatin, mitomycin, bleomycin, adriamycin, 5-fluorouracil, taxol, or in combination with radiation therapy. You can also

  When the composition of the present invention is used as a cachexia ameliorating therapeutic preparation, it can be used in combination with other botanical herbs (herbal medicine, herbal medicine, etc.).

  Examples of plant medicinal herbs include, but are not limited to, for example, eye grass (Iso), red aza, red root (Akanekon), red eyed (Akamegashiwa), agaricus, Aki, Santou Akyo), gelatin, akebi fruits (Kitsuko, Mokutsuushi), akebi vine stems (Kitsuji, Mokutsu), Ashitaba, Asunaro leaves (Asunaroyou), Achacha (Amacha), Achacharu, Flaxseed (Amanin), Abalone Shell (Ishimei, Sekitsukeme), Yurijin (Iklinin), Izui (Amadokoro), 1st place (Araragi, Yew), Fig fruit (Yichijinomi), Fig leaf (Yichijiyo), Ginkgo, Ina seedling (Inenae), Wei Reisen, Iwajisha, Iwabuki, Inchinkou, Menchiin ), Lewd sheep squid (Ikari grass, Yinokukaku), licorice (Yukoku), Ujin (turmeric), quail (Uzuku), 烏 棗 (Uso), bandit bone (Usokkotsu), 烏 ume (Ubai), glaze (Uyaku) , Peony (summer hay, kagosou), surplus food (agaric), back white coral (bill beetle), fruit (age), engorgone, longevity (engaiso), jade (ogi), ogon, yellow spirit , Ocher, yellow duck, cherry bark (Ohhi), wandering (Ohulgyo), Hou Ren (Ouren), Otsu Rafuji (prevented, Bowie), psyllium seeds (carlet, Chazenshi) , Psyllium whole plant (pre-cursor), younger brother (hypergum), distant (onji), kaika, kaikin sand (kaikinsha), kaishi knee (kaigoshitsu), lion (Hakugaishi), Kaimatsuko (Kaishoushi), Sea paulownia bark (Kaidohushi), Makuri, Kaijinso (Kinoshiku), Bakuhaku (Gaihaku), Yakugi (Gaiyou), Mugwort, Kakidooshi, Reindeer (Rensenso), Bamboo leaves (Kakinoha), oyster (Kakinoha), cocoon (Kite), summer hay (Kagosou), lion (Kashi), how many 烏 (Kashu), 莪 朮 (Gadju), cuckoo, kakkon (Kakkon), talc (Kasseki) ), Chamomile, cypress grass (saw), kaya fruit, guarana, potato (kaliroku), coconut (oak), quince fruit (carinomi), mushroom (mokka), karo root (caloron), calf Berries (Karojintsu), Kawaro Jin (Karoin), Kawayanagi (Kawayanagi), Kawaratake (parusal bamboo, Kiseitake), Kawara mugwort (Kin Chen, Inchinkou), Inui (Kankyo), Kanshu, Kanchu ( Licorice, licorice, licorice winter flower, licorice root root, licorice, bellflower, chrysanthemum flower, chrysanthemum flower, kikushi, chrysanthemum husk ), Kisame, Kakitsu, Koji, Kuwayose, Kosecha, Bamboo Bamboo, Kitasashajin, Valerian, Ganoderma Tachibana bark (Kippi), yellowfin (yellow tuna, amber), turtle plate (kiban), gymnema sylvestre, cucumber vine (cucumber), katsukatsu (Kyokatsu), Japanese kite (Kyokatsu), apricot (Kyonin), Izui (Tamatake, Gokukiku) ), Kiran grass, Golden cherry, Kinkan, Kinginka, Ginsai, Kinshinsai , Money grass, goldfish, senkakuso, guava fruit (bamboo bunka), coconut fruit, cucumber fruit seedling, bark root bark (earthbone bark, dicoppi), cocoon Leaves (Kukoyo), bitter ginseng (kujin), kuzu roots (kudzu, kakkon), spinach (kuseki), gardenia, buckwheat (kubaku), kumaraku (kumazasa), kumayanagi (beard willow), walnut, bitter skin ( Krempi), black letters (Kuromoji), mulberry tea (Kwacha), mulberry leaves (Kwanoha), mulberry seeds (Kwanomi), cocoon (Kai-Gai), chicken blood wisteria (Kaiketto), katsura (Keishi), cinnamon (Keihi) , Bay bay leaves, beetle, ginseng, kenshishi, kenji, kensan, ginseng, ginseng, gauze, maltose飴 (Bakugatokatou), safflower (Kouka), communal skin (Gankanhi), stake chrysanthemum (Koukikuka), incense (Koukou), incense (Koushi), incense demand (Kouju), red ginseng (Koujin), incense (Kobushi) ), Glutinous rice (Koubay), Koboku, Kobokujitsu, Kouhon, Gyuhuang, Ekokogi (Gokajin, Gokajin), Gokahi (Gokahi), cow knee ( Goshitsu), Kureyu, Kossaiho, Walnut (Peanut, Kotoniku), Pyrup (Gobai), Kaki, Gyudon, Sesame (Goma), Gomi (Goshi), Pepper (Koroha), Saiko (Psycho), Saiko (Psychoboku), Spicy (Saishin), Pomegranate peel (Ishizuchi pericarp, Sekiryukahi), Saffron, Sayo (Sayo), Yamasuko (Hawthorn), Yamasane Meat Zanik), Sanji-ko, Sanshishi, Sansha, Sanshuyu, Sansho, Sanzukon, Sunzukon, Sanso-nin, Sanbong, Sanyaku, Sanryo, Jio, Jukujio, Shion, Shikajicho, Shikaku, Ekokogi (Sashigaoka, Shigoka), Earth bone skin (jicoppi), purple root (shikon), soft purple root (nanshikon), magnet (diseki), purple quartz (shisekiei), shisoko (shisoshi), shitsuriko (shitsurishi), saiko (jifushi), licorice licorice (Shakanzou), Akaishi fat (Shakuseki), Shakuyaku, Yamato Shakuyaku, Serpentine (Jashobushi), Sasang (Shajin), Kitasashin (Kitashajin), Maeko (Shazenshi), Sha insect (Shachu), Amiko (Shujibushi), Shujibushi (Shujibushi), Zyuyaku, Dokudami, Shredded sand (Shukusha), Minoru Minoru (Shorotsu), Guro leaf (Shuroyo), Ginger (Chrysanthemum), pine resin (Choushu), wheat (Ginger), Sone (Ginger), urn (Ginger), moth (Ginger), Xiao Lian (Ginger), Sadako (Gyotoshi), ground dragon ( Jiryu), bonito, shingi, shingi, gentian, lizard stems and leaves, ninja winter, honeysuckle flowers (gold and silver flowers, goldfish), syringa, cedar, bean drum (Zushi), Drum (Koushi), Blue Saw (Seisoushi), Aoi (Seitai), Aoi (Seishi), Western ginseng (Carrot), Red fox (Sekishak, Stone) Root (Sekishokon), Ishimatsuko (Sekishoushi), Ishizuku pericarp (Sekiryu Kahi), Ishidake (Sekkotsumei), Gypsum (Sekko), Seiko (Sekkoku), Elderberry, Bone (Sekitsukoku), Senkakuso (Senkakoku), All Zenkatsu, River Kyu (Senkyu), Kawadamakin (Zenkoku), Maehu (Zenko), River grain (Senkok), River bone (Senktsu), River knee (Senshitsu), Reed grass, Sensokon), Regression ( Sentai), senna, Kawakai (Senbai), whirling flower (Senpukuka), assembly, Sensen (Senbou), Kawarenko (Senrenshi), grass (Souca), Sakukaku (Sokukakushi), Sakakuko (Sokukakushi) , Persimmon (mushroom), mulberry seed (mulberry coconut, cinnamon), crow ear (mushroom), persimmon (mushroom), grass moth (sowbill), mulberry white skin (sohakuhakuhi), mulberry leopard Persimmon (snow leopard), mulberry leaves (souyou), mulberry leaves (kuwanoha), foliage leaves (sakuhakuyo), sugi (soboku), soba (seoyo), daisyouka (daiwikyo), daihuang (daio), Daikaishi, Daikon grass, Japanese radish seeds (Rashiko, Rabushi), Daiseki, Taiseki, Daiiso, Daisaku, Daifukuhi, Takatogusa, Takusha, Takuran, Turmeric, Cod root bark (Taracompi), Dansang (Tangjin), Pale bamboo leaf (Tankukuyo), Bamboo leaf (Chikuyo), Dandelion root (Hokoeikon), Dandelion (Hong Kong, Hokoei), Chikujo, Chikujinjinjin, Bamboo leaves, Chimo, Tea leaves, Tea leaves Yu), Ding Chou (Chow), Ding Chou (Chou Ji), Choo Sung (Chow To Kou), Cang Tang (Cho Lei), Chin (Chinpi), Prickly Pear (Doutsu Grass, Dotsu Sou), Rust ( Tsuyukusa), Tsurudokudami root, Jukukashu, Tsuruna, Hamasensha, Teirexi, Tenjikuo, Tennansho, Tenma, Tenmokujitsu, Tenmokutsuru (Tenmokuru), Tenmon Fuyu (Tenmondou), Fuyu Toshi (Togashi), Toki (Touki), Fuyu Toshi (Toxi), Kara Sesame (Toshigoma), Lantern Grass (Toujinso), Ginseng (Toujin), Katana Beans (Tows), Cordyceps (Cultiva spruce), Tokatsu Katsu (Tokudokukatsu), Taojin (Tounin), Orange peel (Spruce), This medicine (Toyaku), Assembly, Earthenware Dokakon, Dokajitsu, Dokatsu, Dokudami, Toshishi, Tochinomi, Tochu, Tochu, Dotsuso (Bukryu), mountain return (Sankirai), Dobeckou (Becko), Bekkou (Betkko), bird-stopper (Tritomarazu), Megi (Japanese barberry), Tomburi, Chikiko (Jifushi), Nazuna, Natsume (white sword beans, Hakutozu), jujube, nutmeg, meat beans (Nikuzuk), Narukoyuri's rhizome (yellow spirit, horsetail), soft purple root (nanxikon), Nantenji (nantenjitsu), Nantenyo (nantenyou), Nanshige (nanbange), Nagi (nigaki) ), Meat Juyo (Nikujuyo), Nishiki (Nishikigi), Nukako (Nyuko), Elderberry, Elderberry Leaf (Yo), Carrot, White Ginseng (Hakujin), Shinobi Winter (Nindo) ), Rat seeds (Matsuko, Toshoushi), mouse mochi, female Sadako (Jotei), shellfish (Baimo), malt (Bakuga), white lion (Hakugaishi), lion Jin (Hakushinin), white shark (Hakuzuku), white Fresh skin (Hakusenpi), bald eagle (Hakutou), white peach blossom (Hakutouka), white sword bean (Hakutozu), white southern heaven (Shironanten), Nantenji (nantenjitsu), white pea (Hakuhenzu), barley winter (Bakumontou), 巴Bald tempura, shredded paper, boxfish, radish root, lotus seeds, octagonal, daikon kyoto, pigeon, sardine pigeon, hanamotsu, hub grass, Koji hub tea, Hama Sensha (Hamajisha), Hamabofu (Hanbofu), 蕃 果 (Bangka), Hanka, Banzakuro leaf, Guava leaf, Hanamuren, Hanshiren (Banse) Ryuyo), guava leaves, hantaikai, daikaishi, banyankon, hikai, cluster amaryllis (higanbana), hikikoshi (long life grass, enmeisou), hinoki (hishinomi), dried leaves (hiba), Cinnamon, Castor Sesame, Lily, Sandalwood, Sandalwood, Sandalwood, Sandalwood, Hyakubukon, White Flower Serpentine (Bicaccia japonicum), white cucumber (Biacukyu), white birch (Biakyokusan), hill, syrup (Sweet), birch leaf (Biwayo), loquat leaf, coconut (Binrouji), bonsai (Fukubonshi),茯苓 (Bukuryo), Tsutsumi (Bushi), Red Roughness (Benizarasa), Osamu (Henchiku), Prevention (Bouui), Sone (Boukon), Worm (Bouchi) C), Windproof (Bow Fu), Bamboo (Hubushi), Huang Hou (Hou), Waku Sok (Bokukoku), Bonebone Oil (Hakotsushi), Wuhu Paper (Hakoshi), Peony Skin (Boppi), Oyster (Borei) , 瑰 花 (maikaika), mao (maou), parasol mao (maizen), mao radish (maoukon), macri (marine herb, macri), machinin (mashinin), matababi vine (crane), heaven tree vine (Tenmokutsuru), Matatabi fruit, Amagi fruit (Tenmokujitsu), pine nut (Matsunomi), Haimatsuko (Kaishushiushi), Matsuba (Matsuba), Matsufuji (Matsufuji), Matsuyani, Matsuwa (shoushi), vine (Mankeishi) ), Mitsumouka, Beeswax beeswax, Milobaran, Oak, Fig fruit (no flower, Mukaka), Fig leaf, Meguri tree, Cotton chin (Mentinchin), Bandit (Mokuzoku), Tree Tsutsu (Mokutsu), Kitsuko (Mokutsuushi), Kite Tengu (Mokuten Ryo), Mata Tabi's Aneurysm (Mushi Kobu), Kiso (Mokka), Mika (Mokkou), Peach Leaves (Momonoha), Horsetail, Gate Mongkei, Yakuchi, Yakuchi, Yakuchinin, Yakumosou, Yakouto, Yashajitsu, Yatsumelan, Bear Gall (Yutan), under the snow (Yukinoshita), lily leaf, lily root (lily, sandalwood), yokuinin, thunder circle (raigan), 莱 fukuko (lifekushi), arabiko (rabushika), rahanka (Recompilation), Longan (Ryuganiku), Liu Yid (Ryukido), Ryu (Ryukotsu), Ryutan (Ryutan), Ryokyo (Ryoku), Mung Bean (Ryokuzu), Ganoderma (Ryokuzu), Renji (Lenghi) C) RenSenkusa (Rensensou), lotus meat (Ren'niku), antler (six-rowed), Rohachibo (Rohoubou), road-road communication (Rorotsuu), and the like sum 羌活 (Wakyoukatsu).

  The Chinese herbal medicine preparation is not particularly limited, but includes various Chinese herbal extract preparations that have been approved for use by the Ministry of Health and Welfare.

4). Administration form The administration form of the composition of the present invention is not particularly limited, and for example, oral administration, topical administration, one-shot intravenous injection, intravenous infusion, continuous intravenous infusion, intraarterial injection, intraperitoneal administration, subcutaneous administration, cavity Such as internal administration.

  Although the dosage form of the composition of this invention is not specifically limited, It can be an oral agent and a parenteral agent. For example, in the present invention, a material containing a dried peanut, a peanut extract, or a dried product of the previous extract can be processed into the following dosage form.

  Examples of oral preparations include internal preparations such as capsules, powders, granules, liquids, syrups, and drinks. In this case, a binder, an excipient, a swelling agent, a lubricant, a sweetener, a flavoring agent and the like can be used together with the composition of the present invention. Here, the tablets can also be coated with shellac or sugar. Moreover, the capsule can also contain liquid carriers, such as fats and oils, in said material. Syrups and drinks may contain sweeteners, preservatives, pigment flavors and the like.

  Examples of parenterals include external preparations such as ointments, creams, and liquids, injections, and suppositories. As a base material for external preparations, petrolatum, paraffin, fats and oils, lanolin, macrocold, etc. are used, and can be made into ointments, creams and the like by ordinary methods. Examples of injections include liquids, desiccants, and lyophilization agents. The desiccant and lyophilizer are used aseptically dissolved in distilled water for injection or physiological saline at the time of use.

  A food preparation can be prepared using the composition of the present invention as an active ingredient. In this case, the food preparation has an anti-cachexia effect. Further, in this case, by adding various food materials or beverage materials, for example, a food preparation in the form of powder, tablet, capsule, liquid (drink) can be obtained. Moreover, you may add a base material, an excipient | filler, an additive, a subsidiary material, a bulking agent, etc. to this food formulation suitably. The food preparation is preferably taken orally in several divided doses per day.

  In addition, the addition of other functional substances (for example, mushrooms such as Japanese matsutake, ganoderma mushrooms, and bamboo shoots, extracts thereof and processed products thereof) to the food preparation of the present invention is a different mechanism. It is preferable in that various effects are exhibited.

  These food preparations are used for humans or non-human animals who want to improve cachexia or prevent the occurrence of cachexia in diseases such as cancer or tumors, diabetes, endocrine diseases, blood system diseases, tuberculosis, etc. Is done.

  EXAMPLES Hereinafter, although this invention is demonstrated further more concretely based on an Example, this invention is not limited to this Example.

  Preparation of active ingredient of Nankin goby: Nankin goby was collected from the Heiwa Prefectural Hospital, China, and collected from the producing area. The epidermis of fresh root bark was removed to obtain 15 grams of soft tissue part and endothelium. These soft tissue parts and endothelium were immersed in 100 ml of distilled water and allowed to stand at low temperature (2 to 8 ° C.) for 24 hours. The soaked solution was used as a peanut extract. This extract was orally administered to patients. Three days later, the second administration was performed, and further three days later, the third administration was performed. Three weeks later, changes in clinical symptoms before and after administration were compared and evaluated.

  Clinical symptom findings were classified into the following grades and evaluated numerically.

  0: No symptoms. I: Mild (slight symptom but not so worrisome). II: Moderate (subject to symptom but patient) III: Altitude (strong symptom, disturbing daily life).

  We explained the program of this experiment and the merits and risks of participating in this experiment to the subjects, and conducted the experiment after obtaining consent.

  Subject C, male, age 63, abandoned treatment due to esophageal squamous cell carcinoma (middle), terminal stage, disease progression, etc. The clinical findings showed symptoms peculiar to cachexia such as weight loss (II), fatigue (III), expressionless facial appearance (III), loss of appetite (III), lower limb edema (I).

  Evaluation was performed 3 weeks after administration of peanut. Clinical findings included reduced fatigue (II), markedly improved mental status (II), appetite recovery (II), and reduced postprandial nausea (I). There was also a slight improvement (I) in lower limb edema. Body weight increased from 57.5 kg to 59.3 kg (FIG. 1).

  The improvement of clinical index in this case was extremely remarkable, and the effect of nankin goby on cachexia improvement treatment was recognized.

  Subject L, male, 57 years old, gastric mucinous adenocarcinoma, terminal stage. Clinical findings are characteristic of cachexia such as lean (II), malaise (III), pale complexion (I), anorexia (III), lower limb edema (I), and extremely low daily behavior (III) Symptoms were seen. Similar to Subject C, treatment was abandoned because there was no effective treatment method.

  Clinical findings 3 weeks after administration of peanuts showed significant improvement in mental status (I), recovery of appetite (II), reduced postprandial nausea (I), and improvement in lower limb edema (I) . Daily behavior, especially walking, increased significantly (I), and I was able to deal with patrols on my own. Body weight increased from 51.5 kg to 52.5 kg (FIG. 1).

  The improvement of clinical index in this case was extremely remarkable, and the effect of nankin goby on cachexia improvement treatment was recognized.

  From the above results, it has been clarified that Nankin goby has a cachexia improving therapeutic action. In addition, it was also found that there is reproducibility in the cachexia improving effect of peanut.

  The peanut and / or extract thereof of the present invention can be used as pharmaceuticals, quasi drugs and food preparations.

Changes in subjective symptoms by administration of peanut extract

Explanation of symbols

None.

Claims (2)

A cachexia-improving therapeutic preparation comprising peanut and / or an active ingredient thereof. The cachexia prevention and / or improvement food formulation which contains the cachexia improvement formulation of Claim 1 as an active ingredient.

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