JP2008230994A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic which contains a 4-methoxysalicylate salt and has properly increased viscosity, and to provide a method for producing the cosmetic. <P>SOLUTION: The method for producing the cosmetic is characterized by dissolving gellan gum and a 4-methoxysalicylate salt at high temperature, cooling the solution to produce the gel, crushing the gel, to produce a fine gel-like composition, and adding the fine gel-like composition to a cosmetic. Thus, the suitably thickened cosmetic is prepared. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a cosmetic containing a fine gel composition obtained by pulverizing a gel. More specifically, the present invention relates to a cosmetic composition in which gellan gum and 4-methoxysalicylate are dissolved at a high temperature and then cooled to form a gel, and a fine gel composition obtained by pulverizing the gel is blended. Moreover, it is related with the manufacturing method of this cosmetics.

Whitening agents used in cosmetics include vitamin C derivatives, arbutin, 4-methoxysalicylate, and the like. Among these, 4-methoxysalicylate is a drug expected to have a high whitening effect. However, when 4-methoxy salicylate is blended, the viscosity of the gel is lowered, and it is difficult to prepare a cosmetic material having an appropriate viscosity. There is a possibility that an agent having an appropriate viscosity can be prepared by increasing the amount of the thickener. However, when the amount of the thickener is increased, there is a drawback that the conventional feeling is not fresh and sticky.

An important factor in evaluating cosmetics is the feeling of use and stability. Attempts have been made to apply gellan gum to a composition for external use because of its unique feeling of use and the fact that it exhibits a thickening action even under electrolyte addition conditions. In recent years, studies have been made to prepare fine gels by adding gels made from gellan gum by adding alkali metal or alkaline earth metal cations such as sodium and calcium, and applying them to thickened external compositions. (See Patent Document 1).
Further, a gel composition containing gellan gum and an electrolyte that releases ammonium ions has been studied. (See Patent Document 2)
However, when 4-methoxysalicylate is simply blended in a prescription system thickened using gellan gum, the viscosity of the gel is lowered, and it is not possible to prepare a cosmetic material that is moderately thickened.
JP 9-20649 A JP 2004-196709 A

  This invention makes it a technical subject to mix | blend 4-methoxy salicylate and to provide the cosmetics moderately thickened. Moreover, let it be a technical subject to provide the manufacturing method of this cosmetics.

  As a result of diligent research to solve the conventional problems, the present inventors dissolved gellan gum and 4-methoxysalicylate at a high temperature, then cooled to produce a gel, and the gel was pulverized. It has been found that a cosmetic composition having a moderately thickened viscosity can be obtained by blending the gel composition into the cosmetic composition, and the present invention has been completed.

That is, in the present invention, gellan gum and 4-methoxysalicylate are dissolved at 80 to 95 ° C. and then cooled to a temperature below the temperature at which the gel is formed to produce a gel. It is related with the cosmetics characterized by mix | blending.
In the present invention, gellan gum and 4-methoxysalicylate are dissolved at 80 to 95 ° C., and then cooled to a temperature below the temperature at which the gel is formed to produce a gel. It is related with the manufacturing method of the cosmetics characterized by mix | blending.

  According to the present invention, gellan gum and 4-methoxysalicylate are dissolved at a high temperature, cooled to form a gel, and a fine gel composition obtained by pulverizing the gel is blended into a cosmetic. A thickened cosmetic can be provided.

Hereinafter, preferred embodiments of the present invention will be described in detail.
The gellan gum in the present invention is U.S. S. A. Developed by Kelco, Inc., which is composed of glucose, glucuronic acid and rhamnose produced by Pseudomonas erodea in a medium mainly composed of glucose (glucose: glucuronic acid: rhamnose = 2: 1: 1). Ratio)), which is mainly composed of heteropolysaccharide. In addition, its molecular weight is about 670,000 to 920,000, and it is an industrial product with high purity that is industrially produced under complete production control. As shown in the following formula, the structural formula is a linear high-molecular polysaccharide composed of repeating 1-3 linked glucose, 1-4 bonded glucuronic acid, 1-4 bonded glucose, and 1-4 bonded rhamnose. is there.

  0.001-1.5 mass% is preferable with respect to the whole external composition, and, as for the compounding quantity of the gellan gum in this invention, 0.005-1.0 mass% is especially preferable. When the blending amount is less than 0.001% by mass with respect to the entire external composition, it becomes practically difficult to sufficiently gel, and when it exceeds 1.5% by mass with respect to the entire external composition. A film peculiar to a polymer is formed on the system, and when used on the skin, the feeling of use is impaired.

  The kind of 4-methoxysalicylate salt used in the present invention is not particularly limited as long as it is a pharmaceutically acceptable salt. For example, an alkali metal such as sodium salt, potassium salt, calcium salt is used. In addition to salts or alkaline earth metal salts, salts such as ammonium salts and amino acid salts can be mentioned. Of these, potassium 4-methoxysalicylate is preferable in that it can provide a gel having high transparency and stability. In the present invention, 4-methoxysalicylate may be blended or 4-methoxysalicylic acid and an alkali compound that forms a salt may be blended separately.

The blending amount of 4-methoxysalicylate in the present invention should be appropriately selected according to the specific dosage form of the external preparation for skin and the balance with other blending components, and is particularly limited. Although it is not, it is preferable that it is 0.001-10.0 mass% with respect to the whole external composition, More preferably, it is 0.01-5.0 mass%. When the blending amount of 4-methoxysalicylate is less than 0.001% by mass relative to the entire composition for external use, it is difficult to sufficiently exhibit the whitening effect, and it is blended exceeding 10.0% by mass. However, the improvement of the whitening effect commensurate with the increase in the amount of blending is hardly recognized, and the tendency to promote a rather sticky feeling of use is strong, which is not preferable.

In this invention, after melt | dissolving gellan gum and 4-methoxy salicylate at high temperature of 80-95 degreeC, it cools below to the temperature which forms a gel, and produces a gel. Usually, since the solution containing gellan gum gels at 38 degrees C or less, Preferably it cools to 15-38 degreeC, More preferably, it is 20-35 degreeC. A whitening cosmetic can be provided by blending the cosmetic with a fine gel composition obtained by pulverizing the gel using a homomixer or the like.
The cosmetic compounded with the pulverized gel may be any of a transparent liquid, a translucent liquid, an O / W emulsified aqueous phase, and a W / O emulsified aqueous phase. It is also possible to blend in a three-phase system in which powders are further dispersed.

Even if other cosmetic ingredients are blended without heating and dissolving a mixture of gellan gum and 4-methoxysalicylate, a cosmetic having an appropriate viscosity cannot be obtained.
The gel obtained in the present invention is a stronger gel than a gel prepared using gellan gum and an ascorbic acid derivative, and has a characteristic that it is more stable at high temperatures and more fresh and non-sticky.

In the present invention, in addition to the essential components described above, other components that can be usually blended in the composition for external use can be blended as long as the desired effects of the present invention are not impaired.
For example, hydrocarbons such as liquid paraffin, squalane and petrolatum; fats and oils such as macadamia nut oil, olive koji and lanolin; waxes such as jojoba oil, carnauba wax and candelilla wax; silicones such as dimethylpolysiloxane and methylphenylsiloxane Higher alcohols such as capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol, phytosterol; higher fatty acids such as capric acid, myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid, linolenic acid; Polyethylene glycol, glycerin, 1,
Moisturizers such as 3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, mucopolysaccharide, hyaluronic acid, chondroitin sulfate, chitin, chitosan; lower alcohols such as ethanol; antioxidants such as butylhydroxytoluene, tocopherol, and phytin; Antibacterial agents such as benzoic acid, salicylic acid, sorbic acid, paraoxybenzoic acid alkyl ester, hexachlorophene, and the like can be appropriately blended.

  Amino acids such as glycine, alanine, valine, leucine, threonine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamine, taurine, histidine and their alkali metal salts and hydrochlorides; acyl sarcosine acids (eg, lauroyl sarcosine sodium), glutathione Organic acids such as citric acid, malic acid, tartaric acid and lactic acid; vitamin A and its derivatives; vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, vitamin B12, vitamin B15 and its derivatives Vitamin B such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, etc .; vitamin D; vitamins such as vitamin H, pantothenic acid, panthetin, etc. Nicotinamide, benzyl nicotinate, γ-oryzanol, allantoin, glycyrrhizic acid (salt), glycyrrhetinic acid and its derivatives, hinokitiol, bisabolol, eucalyptol, thymol, inositol, saikosaponin, carrot saponin, hetimasaponin, muclodisaponin Various drugs such as saponins such as pantothenyl ethyl ether, ethinyl estradiol, tranexamic acid, arbutin, cephalanthin, and placenta extract; borage, clara, corn, orange, sage, yarrow, zebra, thyme, thyme, spruce, spruce, birch , Natural extracts extracted with various solvents such as horsetail, loofah, maroonier, yukinoshita, arnica, lily, mugwort, peonies, aloe, gardenia, sawara, etc .; neutralizing agent, Antioxidants, pigments, fragrances, purified water and the like can be appropriately blended.

  The embodiment of the present invention is as follows. However, the unit of the amount is mass%.

Example 1: Solubilized whitening cosmetic liquid A parts ethanol 10.0
PPG-13
Decyltetradeces-24 0.3
Methyl paraoxybenzoate 0.1
Phenoxyethanol 0.1
Fragrance Mentyl lactate 0.004
B parts glycerin 2.0
PEG / PPG-14 / 7 dimethyl ether 3.0
Dipropylene glycol 1.0
1,3 Butylene glycol 5.0
Juyaku extract 0.5
Karin extract 0.1
Dipotassium glycyrrhizinate 0.05
Purified water Residual C parts purified water 52.0
Gellan gum 0.2
4-methoxysalicylic acid potassium salt 1.0
"Production method"
The alcohol phase of A was added to the aqueous phase of B and solubilized to prepare a lotion. Phase C gellan gum was dissolved at 85 ° C., potassium 4-methoxysalicylate was added, cooled to 25 ° C. (room temperature), solidified, crushed, and added to the skin lotion.

Example 2: Sheet-like impregnated mask of solubilized whitening cosmetic liquid “Production method”
The cosmetic liquid of Example 1 was further impregnated into a non-woven fabric to obtain a solubilized whitening cosmetic liquid-impregnated sheet-like mask.

Example 3: Solubilized whitening cosmetic liquid A parts ethanol 10.0
PPG-13 Decyltetradeceth-24 0.3
Methyl paraoxybenzoate 0.1
Phenoxyethanol 0.1
Fragrance Trace B parts Glycerin 2.0
PEG / PPG-14 / 7 dimethyl ether 3.0
Dipropylene glycol 1.0
1,3 Butylene glycol 5.0
Beech bud extract 0.5
Asenya extract 0.1
Yukinoshita Extract 0.1
Licorice extract 0.3
Peonies extract 0.5
ONONIS EXTRACT 0.3
Mishima psycho root extract 0.1
Rose extract 0.3
Dipotassium glycyrrhizinate 0.05
Purified water Residual C parts purified water 56.0
Gellan gum 0.2
4-methoxysalicylic acid potassium salt 1.0
"Production method"
The alcohol phase of A was added to the aqueous phase of B and solubilized to prepare a lotion. Phase C gellan gum was dissolved at 85 ° C. and potassium 4-methoxysalicylate was added, then cooled to 25 ° C. (room temperature), and the solidified product was pulverized and added to the skin lotion.

Example 4: Sheet-shaped impregnated mask of solubilized whitening cosmetic liquid The cosmetic liquid of Example 2 was further impregnated into a nonwoven fabric or the like to obtain a solubilized whitening cosmetic liquid-impregnated sheet-shaped mask.

Example 5: Whitening Milk A Parts Dimethicone 1.0
Squalane 1.0
Cetyl ethylhexanoate 2.0
Carboxyvinyl polymer 0.2
Fragrance Trace B parts Glycerin 2.0
Polyoxyethylene hydrogenated castor oil 0.3
Methyl paraoxybenzoate 0.1
Phenoxyethanol 0.1
PEG / PPG-14 / 7 dimethyl ether 3.0
Dipropylene glycol 1.0
1,3 Butylene glycol 5.0
Oat extract 0.3
Hinogi extract 0.3
Loquat extract 0.5
Aloe extract 0.3
Ginger extract 0.1
Dipotassium glycyrrhizinate 0.05
Purified water Residual caustic potash appropriate amount C parts purified water 52.0
Gellan gum 0.2
4-methoxysalicylic acid potassium salt 1.0
"Production method"
After the oil phase of A is added to the aqueous phase of B and emulsified, the gellan gum of phase C is dissolved at 85 ° C. and 4-methoxysalicylic acid potassium salt is added, and then cooled to 25 ° C. (room temperature) and solidified. The emulsion was crushed to obtain an emulsion.

Example 6: Emulsion sheet-like impregnated mask The emulsion of Example 5 was further impregnated into a nonwoven fabric or the like to obtain an emulsion-impregnated sheet-like mask.

Example 7: Whitening whitening serum A parts diglyceryl diisostearate 0.2
PEG-60 hydrogenated castor oil 0.2
Glyceryl tri-2-ethylhexanoate 0.3
Methyl paraoxybenzoate 0.17
Fragrance Trace B parts Glycerin 3.0
1,3 Butylene glycol 9.5
C parts caustic potash appropriate amount dipotassium glycyrrhizinate 0.05
Artemisia extract 0.3
Hamelis Extract 0.1
Chamomile extract 0.5
Purified water Residual D parts purified water 52.0
Gellan gum 0.2
4-methoxysalicylic acid potassium salt 1.0
"Production method"
The A phase was mixed with the B phase and then added to the C aqueous phase to prepare a cloudy lotion. Dissolve D-phase gellan gum at 85 ° C., add 4-methoxysalicylic acid potassium salt, cool and pulverize to 25 ° C. (room temperature), and add to the cloudy lotion to obtain a translucent serum. It was.

Example 8: Sheet-like impregnated mask of translucent whitening cosmetic liquid The cosmetic liquid of Example 7 was further impregnated into a nonwoven fabric or the like to obtain a solubilized whitening cosmetic liquid-impregnated sheet-shaped mask.

Example 9: Whitening Cream A Parts Squalane 10.0
Cetanol 5.0
Vaseline 1.0
Cetyl ethylhexanoate 1.0
Trioctanoin 2.0
PEG-60 glyceryl isostearate 2.5
Glyceryl stearate 2.8
Fragrance Trace B parts Glycerin 2.0
Methyl paraoxybenzoate 0.1
Phenoxyethanol 0.1
PEG / PPG-14 / 7 dimethyl ether 3.0
Dipropylene glycol 1.0
1,3-butylene glycol 5.0
Dipotassium glycyrrhizinate 0.05
Purified water Residual caustic potash appropriate amount C parts purified water 52.0
Gellan gum 0.2
4-methoxysalicylic acid potassium salt 1.0
"Production method"
After the oil phase of A is added to the aqueous phase of B and emulsified, the gellan gum of phase C is dissolved at 85 ° C. and 4-methoxysalicylic acid potassium salt is added, and then cooled to 25 ° C. (room temperature) and solidified. The cream was crushed to obtain a cream.

Comparative Example 1: White turbid whitening serum In the formulation of Example 7, A phase was mixed with B phase, then added to C aqueous phase, D phase was dissolved in the obtained cloudy lotion, A translucent serum was obtained. (No hot melt)

“Evaluation” The results of evaluating Example 1 according to the evaluation criteria described later are shown.

(1) Evaluation of Usability For each cosmetic, a cosmetic use test was conducted by five specialist panels, and the following evaluations were made regarding the non-stickiness / freshness at the time of application and the non-stickiness / freshness after use. Evaluation was based on point criteria.
◎: Excellent (4 out of 5 responded that the evaluation items were excellent)
○: Slightly superior (2 to 3 out of 5 responded that the evaluation items were excellent)
Δ: Slightly inferior (1 out of 5 responded that the evaluation item was superior)
X: Inferior (out of 5 respondents said that 0 are superior in terms of evaluation items)

(2) Evaluation of viscosity
The viscosity (room temperature) immediately after trial production was measured and evaluated using a bismetholone viscometer VDA (manufactured by Shibaura System Co., Ltd.)
A: Very viscous (exceeds 5000 mPa · s)
○: Viscosity (500 mPa · s to 5000 mPa · s)
Δ: Some viscosity (50 mPa · s to 500 mPa · s)
×: No viscosity (less than 50 mPa · s)

Claims (2)

  Gelatin gum and 4-methoxysalicylate are dissolved at 80 to 95 ° C., then cooled to a temperature below the temperature at which the gel is formed to produce a gel, and a fine gel composition obtained by pulverizing the gel is blended And cosmetics.   Gelatin gum and 4-methoxysalicylate are dissolved at 80 to 95 ° C., then cooled to a temperature below the temperature at which the gel is formed to produce a gel, and a fine gel composition obtained by pulverizing the gel is blended A method for producing cosmetics.