JP2008206630A - Transfusion pump apparatus and control method of transfusion pump apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a transfusion pump apparatus accurately managing the injection amount of a liquid medicine by a simple configuration. <P>SOLUTION: The transfusion pump apparatus 1 for injecting the liquid medicine enclosed in a liquid medicine container 2 into the body of a patient 3 is provided with a pump 4 to be intermittently driven to pressurize and discharge the liquid medicine, a transfusion tube 5 through which the liquid medicine passes, and a discharge side pressure sensor 7 for detecting the pressure of a discharge side tube part 27b arranged more on the discharge side than the pump 4 of the transfusion tube 5. Also, the transfusion pump apparatus 1 is provided with a control section for detecting the residual pressure of the discharge side tube part 27b after the lapse of prescribed time from the time of detecting the maximum pressure of the discharge side tube part 27b when the pump 4 is intermittently driven on the basis of an output result from the discharge side pressure sensor 7 and performing prescribed processing on the basis of the detected result of the residual pressure. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an infusion pump device for injecting a drug solution into a human or animal body and a method for controlling the infusion pump device.

  Conventionally, for example, an infusion pump device for injecting a pain relief drug solution (analgesic agent) to a cancer patient has been used in the medical field. As such an infusion pump device, an infusion pump device including a finger-type pump that pressurizes and discharges a chemical solution in an infusion tube with pump fingers arranged vertically is known (for example, see Patent Document 1).

  The infusion pump device described in Patent Document 1 includes a catheter connected to an infusion tube and a blockage detection sensor (pressure sensor) disposed between the filter and the pump. If the catheter or filter is clogged and a pressure exceeding the pressure resistance is applied to each component of the infusion pump device such as an infusion tube, each component of the infusion pump device is damaged. For this reason, the infusion pump device described in Patent Document 1 detects the maximum pressure in the infusion tube with an occlusion detection sensor, and issues an alarm when the maximum pressure is equal to or higher than a set pressure.

JP 2000-300667 A

  For example, in order to improve the quality of life of patients with end-stage cancer, etc., it is considered that the need to more appropriately relieve patient pain will increase in the future. Here, in order to alleviate the patient's pain more appropriately, it is necessary to accurately manage the amount of the chemical solution injected by the infusion pump device.

  However, when the catheter or the filter is clogged with a foreign substance, pressure loss occurs even if each component of the infusion pump device is not damaged. Pressure loss also occurs when air is mixed when the catheter is connected to the infusion tube and the filter is clogged by air bubbles, or when the diameter of the catheter connected to the infusion tube is extremely thin. For this reason, it becomes difficult to accurately manage the injection amount of the chemical solution by the infusion pump device.

  In addition, if the flowmeter which measures the flow volume of a chemical | medical solution is installed in the infusion pump apparatus of patent document 1, it will become possible to manage the injection amount of a chemical | medical solution with sufficient precision. However, there is no current flow meter that is a small-sized flow meter that can be installed in the infusion pump device described in Patent Document 1 and that can accurately measure the flow rate of a small amount of chemical liquid.

  Therefore, an object of the present invention is to provide an infusion pump device and a method for controlling the infusion pump device that can accurately manage the injection amount of a chemical solution with a simple configuration.

  In order to solve the above-described problems, the present invention provides an infusion pump device for injecting a medicinal solution sealed in a medicinal solution container into a human or animal body, and a pump that drives the medicinal solution while pressurizing it intermittently. And an infusion tube through which the chemical solution passes, a discharge side pressure sensor for detecting the pressure of the discharge side tube portion disposed on the discharge side of the pump of the infusion tube, and an output result from the discharge side pressure sensor And a control unit that detects a residual pressure in the discharge side tube unit after a predetermined time has elapsed since the maximum pressure detection of the discharge side tube unit during intermittent driving of the pump and performs a predetermined process based on the detection result of the residual pressure It is characterized by providing.

  In the infusion pump device of the present invention, the control unit is configured to control the discharge side tube unit after a predetermined time has elapsed from the time when the maximum pressure of the discharge side tube unit is detected during intermittent driving of the pump, based on the output result from the discharge side pressure sensor. Residual pressure is detected. Here, if the residual pressure in the discharge-side tube portion has dropped to a predetermined pressure after a lapse of a predetermined time after the pump has been intermittently driven, the chemical liquid discharged from the pump will enter the body of a person or animal (human etc.) Presumed to be injected. On the other hand, if the residual pressure of the discharge side tube portion does not drop to a predetermined pressure after the lapse of a predetermined time after the intermittent drive of the pump, the chemical discharged from the pump remains in the infusion tube, and the discharged chemical Is not expected to be injected into human bodies. Therefore, it becomes possible for the control unit to detect whether or not a predetermined amount of chemical solution is injected into the body of a person or the like by detecting the residual pressure in the discharge side tube unit. That is, it is possible to estimate whether or not a predetermined amount of chemical liquid is injected into the body of a person or the like with a simple configuration using the discharge side pressure sensor.

  Moreover, in the infusion pump apparatus of this invention, the control part is performing the predetermined | prescribed process based on the detection result of the residual pressure of a discharge side tube part. That is, the control unit performs a predetermined process based on an estimation result as to whether or not a predetermined amount of chemical solution is injected into the body of a person or the like. Therefore, by performing this predetermined process, it is possible to accurately manage the injection amount of the chemical solution.

  In this invention, it is preferable that a control part detects the residual pressure at the time of starting of the intermittent drive of a pump. If comprised in this way, the quantity of the chemical | medical solution inject | poured by one intermittent drive of the pump can be estimated more appropriately. Therefore, it becomes possible to manage the injection amount of the chemical solution with higher accuracy.

  In the present invention, the infusion pump device includes a display unit and / or an alarm generation unit for notifying a change in the residual pressure, and the control unit determines that the residual pressure reaches a predetermined set residual pressure based on the detection result of the residual pressure. A warning display informing that an abnormality that does not decrease has occurred is displayed on the display unit, and / or an alarm informing that an abnormality has occurred in which the residual pressure does not decrease to a predetermined residual pressure is generated in the alarm generation unit. preferable. If comprised in this way, a patient himself / herself, a doctor, a nurse, etc. can be notified that the predetermined amount of chemical | medical solution is not inject | poured into the patient's body, for example. Therefore, a patient, a doctor, a nurse, or the like can take a predetermined treatment so that a predetermined amount of the chemical solution is injected based on the warning display or alarm. For example, a catheter or filter can be exchanged.

  Here, in general, the infusion pump device operates for a predetermined time based on the set value of the unit injection flow rate that is the injection flow rate per unit time of the chemical solution and the set value of the total injection amount of the chemical solution to a person, etc. Stop after a predetermined time. At this time, the infusion pump device is intermittently driven at a set fixed interval. In other words, even if a predetermined amount of drug solution is not actually injected into the patient, the infusion pump device stops after a predetermined time has elapsed. Therefore, in the present invention, the control unit controls the pump based on the detection result of the residual pressure so as to extend the time for injecting the chemical solution necessary for injecting the predetermined amount of the chemical solution in the chemical solution container into the person or animal. It is preferable to control the pump so as to shorten the interval of intermittent driving of the pump. If comprised in this way, it will become possible to inject | pour a predetermined amount of chemical | medical solutions reliably into a person etc. (namely, with sufficient precision).

  In the present invention, the infusion pump device includes an input unit to which a unit injection flow rate that is an injection flow rate per unit time of the chemical solution and a total injection amount of the chemical solution are input, and the control unit is a unit injection input from the input unit It is preferable to set the total number of times the pump is driven from the flow rate and the total injection amount, and to increase the total number of times the pump is driven based on the detection result of the residual pressure, thereby extending the chemical solution injection time. If comprised in this way, chemical | medical solution injection | pouring time can be extended by simple structure of increasing the frequency | count of a drive of a pump.

  In order to solve the above-described problems, the present invention provides an infusion pump device for injecting a chemical solution sealed in a chemical solution container into a human or animal body. Pump, the infusion tube through which the chemical solution passes, the discharge side pressure sensor for detecting the pressure of the discharge side tube portion disposed on the discharge side of the infusion tube, and the output result from the discharge side pressure sensor Based on the above, during the intermittent drive of the pump, it detects the decrease time from when the pressure of the discharge side tube portion reaches the maximum pressure until the pressure of the discharge side tube portion drops to a predetermined pressure, and also detects the decrease time And a control unit that performs predetermined processing based on the result.

  In the infusion pump device of the present invention, the control unit determines the pressure of the discharge side tube unit from the time when the pressure of the discharge side tube unit reaches the maximum pressure during intermittent driving of the pump, based on the output result from the discharge side pressure sensor. The time until the pressure drops to a predetermined pressure is detected. Here, if the decrease time from when the pressure of the discharge side tube portion reaches the maximum pressure to when it decreases to a predetermined pressure is short, the chemical liquid discharged from the pump is smoothly injected into the body of a person or the like It is estimated to be. On the other hand, if the time until the pressure of the discharge side tube section decreases to a predetermined pressure is long, the chemical liquid discharged from the pump stays in the infusion tube, and the discharged chemical liquid is smooth in the human body. It is estimated that it was not injected. For this reason, it is possible to estimate whether or not a predetermined amount of chemical solution is injected into the body of a person or the like by the control unit detecting the pressure drop time. Moreover, in the infusion pump apparatus of this invention, the control part is performing the predetermined process based on the detection result of fall time. That is, the control unit performs a predetermined process based on an estimation result as to whether or not a predetermined amount of chemical solution is injected into the body of a person or the like. Therefore, by performing this predetermined process, it is possible to accurately manage the injection amount of the chemical solution.

  Furthermore, in order to solve the above-described problems, the present invention provides an infusion pump device for pressurizing and discharging a chemical solution intermittently in a control method of an infusion pump device for injecting a chemical solution sealed in a chemical solution container into a human or animal body. Based on the output result from the discharge-side pressure sensor for detecting the pressure of the discharge-side tube part arranged on the discharge side of the pump drive step and the infusion tube through which the chemical solution passes and the discharge side of the pump The residual pressure detection step for detecting the residual pressure in the discharge side tube portion after a lapse of a predetermined time from the detection of the maximum pressure in the discharge side tube portion during intermittent driving and the detection result of the residual pressure detected in the residual pressure detection step And a processing step for performing predetermined processing based on the processing step.

  In the control method of the infusion pump device of the present invention, in the residual pressure detection step, based on the output result from the discharge side pressure sensor, after a predetermined time has elapsed since the maximum pressure detection of the discharge side tube portion at the time of intermittent drive of the pump. The residual pressure in the discharge side tube portion is detected. Therefore, it is possible to estimate whether or not a predetermined amount of chemical solution is injected into the body of a person or the like. That is, it is possible to estimate whether or not a predetermined amount of chemical liquid is injected into the body of a person or the like with a simple configuration using the discharge side pressure sensor. In the control method of the present invention, a predetermined process is performed based on the detection result of the residual pressure in the processing step. That is, in the processing step, a predetermined process is performed based on an estimation result as to whether or not a predetermined amount of chemical solution is injected into the body of a person or the like. Therefore, by performing this predetermined process, it is possible to accurately manage the injection amount of the chemical solution.

  As described above, with the infusion pump device and the method for controlling the infusion pump device according to the present invention, it is possible to accurately manage the injection amount of the chemical solution with a simple configuration.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings.

(Schematic configuration of infusion pump)
FIG. 1 is a diagram for explaining a schematic configuration inside an infusion pump device 1 according to an embodiment of the present invention. FIG. 2 is a graph showing the relationship between the injection time of the chemical solution injected by the infusion pump device 1 shown in FIG. 1 and the unit injection flow rate that is the injection flow rate per unit time. FIG. 3 is a view showing the relationship between the injection time of the chemical solution injected by the infusion pump device 1 shown in FIG. 1, the pressure of the discharge side tube portion 27b, and the drive timing of the pump 4, and FIG. A state where no clogging has occurred is shown, and (B) shows a state where the filter is clogged.

  The infusion pump device 1 of this embodiment is a device for injecting a drug solution (analgesic agent) into a patient's body in order to relieve pain of a patient such as terminal cancer or a patient after surgery, for example, as shown in FIG. As shown, the chemical liquid sealed in the chemical liquid container 2 is discharged toward the patient 3. Moreover, the infusion pump apparatus 1 of this form is a small pump apparatus which the patient 3 can carry, for example.

  As shown in FIG. 1, this infusion pump device 1 includes a pump 4 that pressurizes and discharges a chemical solution, an infusion tube 5 through which the chemical solution passes, and a chemical solution container 2 and a pump for detecting the pressure of the infusion tube 5. 4, an inhalation-side pressure sensor 6 disposed between 4 and a discharge-side pressure sensor 7 disposed between the patient 3 and the pump 4, and a housing 8 housing these components. In addition, the unit injection flow rate of the chemical solution (the injection flow rate of the chemical solution per unit time) by the infusion pump device 1 of the present embodiment is, for example, 0.1 ml (milliliter) to 20 ml.

  The infusion pump device 1 includes a control unit 9 that performs various controls of the infusion pump device 1 and an input unit that inputs information (operation conditions) necessary for the operation of the infusion pump device 1 as described later. 10 and an alarm generator 11 for generating an alarm when the maximum pressure detected by the discharge-side pressure sensor 7 exceeds a predetermined value in order to prevent damage to each component of the infusion pump device 1. (See FIG. 4). The configurations of the control unit 9, the input unit 10, the alarm generation unit 11, and the like will be described later. In the following description, the right side of FIG. 1 is “right”, the left side is “left”, the upper side is “upper”, and the lower side is “lower”.

  The pump 4 is a peristaltic pump that performs infusion by pressing (pressing) the infusion tube 5. Specifically, the pump 4 is a finger-type pump including three fingers 14 to 16 that press the infusion tube 5. As shown in FIG. 1, the pump 4 includes a motor 17 serving as a drive source for driving the fingers 14 to 16, and a transmission mechanism 18 that transmits power of the motor 17.

  The three fingers 14 to 16 are arranged in this order from the suction side to the discharge side, and press the infusion tube 5 in a predetermined order in order to discharge the drug solution. That is, the fingers 14 to 16 are driven by the motor 17 and the transmission mechanism 18 to move up and down and press the infusion tube 5 at the raised position. The finger 14 mainly plays a role of inhaling a chemical solution. The finger 16 mainly plays a role of discharging the chemical solution. The finger 15 mainly serves to pressurize and discharge the chemical solution. The pump 4 may include four or more fingers.

  The transmission mechanism 18 includes an eccentric cam 19 to 21 that moves the fingers 14 to 16 up and down, a rotary shaft 22 to which the eccentric cam 19 to 21 is fixed, a gear 23 that is fixed to the rotary shaft 22, and an output shaft of the motor 17. And a gear 24 meshed with the gear 23.

  The infusion tube 5 includes a first infusion tube 27 disposed above the pump 4 from the suction side to the discharge side of the pump 4, a second infusion tube 28 connected to the left end of the first infusion tube 27, A third infusion tube 29 connected to the right end of one infusion tube 27; The first infusion tube 27 and the second infusion tube 28 are connected via a connector 30, and the first infusion tube 27 and the third infusion tube 29 are connected via a connector 30.

  The center part of the 1st infusion tube 27 of the left-right direction is pressed by the fingers 14-16. A part of the suction side tube portion 27 a disposed on the suction side of the pump 4 with respect to the first infusion tube 27 is inhaled by a first pressing portion 32 a formed on a lid portion 32 to be described later constituting the housing 8. It is pressed toward the side pressure sensor 6. In addition, a part of the discharge side tube portion 27 b disposed on the discharge side of the first infusion tube 27 is disposed on the discharge side pressure sensor 7 by a second pressing portion 32 b described later formed on the lid portion 32. It is pressed toward.

  The 2nd infusion tube 28 is connected to the chemical | medical solution container 2 via a connector, a check valve, etc. which are not illustrated. The third infusion tube 29 is connected to a check valve (not shown), a catheter, a filter, an injection needle, and the like, and the patient 3 is stabbed with an injection needle connected to the third infusion tube 29.

  The suction side pressure sensor 6 is a pressure sensor for detecting the pressure of the suction side tube portion 27a, and is disposed below the suction side tube portion 27a. In the infusion pump device 1, it is detected from the output result of the suction side pressure sensor 6 that the chemical liquid in the chemical liquid container 2 has run out.

  The discharge side pressure sensor 7 is a pressure sensor for detecting the pressure of the discharge side tube portion 27b, and is disposed below the discharge side tube portion 27b. In the infusion pump device 1, based on the output result from the discharge side pressure sensor 7, the maximum pressure of the discharge side tube portion 27 b is detected in order to protect each component of the infusion pump device 1 as will be described later. As will be described later, the residual pressure in the discharge side tube portion 27b is detected.

  The housing 8 includes a main body 31 that houses the motor 17, the transmission mechanism 18, and the like, and an openable / closable lid 32 that covers the upper surface of the main body 31. A groove portion (not shown) is formed on the upper surface of the main body portion 31, and the infusion tube 5 is disposed in the groove portion. Further, the fingers 14 to 16 protrude upward from the upper surface of the main body 31, and the fingers 14 to 16 retract from the upper surface of the main body 31 toward the inside of the main body 31 (that is, the lower side).

  A first pressing portion 32 a that presses a part of the suction side tube portion 27 a toward the suction side pressure sensor 6 is formed in the lid portion 32 at a position facing the suction side pressure sensor 6. Similarly, a second pressing portion 32 b that presses a part of the discharge side tube portion 27 b toward the discharge side pressure sensor 7 is formed in the lid portion 32 at a position facing the discharge side pressure sensor 7. In addition, the lid portion 32 is formed with a first abutting portion 32 c that crushes (presses) the first infusion tube 27 together with the suction finger 14 at a position facing the suction finger 14. Similarly, a second abutting portion 32 d that crushes (presses) the first infusion tube 27 together with the discharge finger 16 is formed in the lid portion 32 at a position facing the discharge finger 16.

  In the infusion pump device 1 of this embodiment, the pump 4 is driven intermittently to discharge a certain amount of chemical liquid. For example, the pump 4 discharges 0.1 ml of chemical liquid by one driving. Specifically, the pump 4 discharges the chemical liquid by intermittently repeating the following one-cycle operation.

  In this embodiment, the state in which the finger 14 and the finger 16 are raised to press the first infusion tube 27 and the finger 15 is lowered is the standby state of the pump 4. In the standby state, a certain amount of chemical liquid discharged by one intermittent drive is prefilled in the first infusion tube 27 disposed between the finger 14 and the finger 16.

  When the pump 4 is activated in the standby state, the finger 16 is lowered, and then the finger 15 is raised to press the first infusion tube 27. The chemical solution is discharged from the pump 4 by the downward movement of the finger 16 and the upward movement of the finger 15. Then, after the finger 16 is raised and the first infusion tube 27 is crushed, the finger 14 and the finger 15 are lowered, and the drug solution is inhaled. Thereafter, the finger 14 moves up and returns to the standby state described above.

  Further, in the infusion pump device 1 of this embodiment, as shown by the solid line in FIG. 2, the unit injection flow rate (the injection flow rate of the chemical solution per unit time) is usually set to the elapsed time (injection time) from the start of the injection of the chemical solution. Regardless. That is, as indicated by the solid line L1 in FIG. 3, the pump 4 performs the above-described one-cycle operation at a constant drive time interval (drive pitch). When the solid line L1 changes upward in FIG. 3, the pump 4 is intermittently driven (one-cycle operation).

  Here, when the patient 3 feels particularly intense pain, as shown by the broken line in FIG. 2, more chemical solution may be injected in a short time. At this time, the pump 4 is driven at a driving pitch shorter than the driving pitch shown in FIG. Further, when the patient 3 feels particularly intense pain and presses a predetermined input button (not shown) constituting the input unit 10 (see FIG. 4), more chemical solution is injected in a short time.

  When the pump 4 is driven, the pressure of the discharge side tube portion 27b detected based on the output from the discharge side pressure sensor 7 changes as indicated by solid lines L2 and L3 in FIG. That is, as indicated by the solid lines L2 and L3 in FIG. 3, when the pump 4 is activated (when the solid line L1 rises upward), the finger 16 is first lowered, so that the pressure in the discharge side tube portion 27b is temporarily increased. Will decline. Thereafter, since the finger 15 rises, the pressure of the discharge side tube portion 27b rises, and eventually reaches the maximum pressure when the pump 4 is intermittently driven (during one cycle operation). Thereafter, since the chemical liquid discharged from the pump 4 is injected into the patient 3 through a catheter, a filter, and the like, the pressure in the discharge side tube portion 27b gradually decreases.

  Here, when the filter (not shown) connected to the third infusion tube 29 is new and is not clogged (and the catheter is not clogged and the diameter of the catheter is extremely large). 3), even if the pump 4 repeats intermittent driving, the discharge-side tube is not used until the next intermittent operation starts after one intermittent operation, as indicated by the solid line L2 in FIG. The pressure (residual pressure) of the portion 27b is reduced to a predetermined pressure (20 Kpa in the example shown in FIG. 3A).

  On the other hand, when the filter is clogged (or when the catheter is clogged or the diameter of the catheter is extremely thin), as shown by the solid line L3 in FIG. If the pump 4 repeats intermittent driving, the residual pressure in the discharge side tube portion 27b gradually increases when the next intermittent operation starts (when the solid line L1 rises upward). Alternatively, in this case, if the pump 4 repeats intermittent driving, the residual pressure in the discharge side tube portion 27b when the next intermittent operation starts does not decrease to a predetermined pressure. This is because the chemical liquid discharged from the pump 4 in one intermittent operation is not injected into the patient 3 but remains in the first infusion tube 27 or the like due to pressure loss caused by filter clogging or the like. is there. In this way, by detecting the residual pressure in the discharge side tube portion 27b after a predetermined time has elapsed after one intermittent operation, the drug solution discharged from the pump 4 in one intermittent operation is injected into the body of the patient 3. It can be estimated whether it was done. In addition, clogging of the catheter and the filter occurs due to foreign matters, bubbles, etc.

  Moreover, when the chemical | medical solution which should be inject | poured into the patient 3 by one intermittent operation | movement of the pump 4 is not inject | poured, there exists a possibility that the pain of the patient 3 cannot be relieved more appropriately. Therefore, in such a case, it is necessary to perform an appropriate process to more appropriately relieve the pain of the patient 3. Therefore, in this embodiment, as will be described later, it is determined whether or not a chemical solution to be injected into the patient 3 has been injected, and processing as described below is performed.

  As shown by the broken line L4 in FIG. 3B, if the time between intermittent operations of the pump 4 is long (that is, if the unit injection flow rate is small), even if the filter or the like is clogged, the following By the time the intermittent operation starts, the residual pressure in the discharge side tube portion 27b decreases to a predetermined pressure (20 Kpa in the example shown in FIG. 3B). That is, the situation in which the chemical solution to be injected into the patient 3 is not injected does not occur unless the unit injection flow rate is relatively large even when the filter is clogged.

(Schematic configuration of the control unit of the infusion pump device)
FIG. 4 is a block diagram schematically showing the control unit 9 and related devices of the infusion pump device 1 shown in FIG. FIG. 5 is an enlarged graph showing a portion corresponding to the E portion in FIG. FIG. 4 shows only the configuration related to the discharge of the chemical solution by the pump 4, the configuration related to the detection of the pressure of the discharge side tube portion 27b, and the configuration related to the processing after pressure detection.

  As shown in FIG. 4, the control unit 9 includes a pressure detection unit 35 as a configuration related to the discharge of the chemical solution by the pump 4, a configuration related to detection of the pressure of the discharge side tube unit 27 b, and a configuration related to processing after pressure detection. A residual pressure comparison unit 36, a maximum pressure comparison unit 37, an alarm control unit 38, a pump drive unit 39, a pump control unit 40, and a storage unit 41. The components such as the pressure detection unit 35, the residual pressure comparison unit 36, the maximum pressure comparison unit 37, the alarm control unit 38, and the pump control unit 40 are arithmetic means such as a CPU constituting the control unit 9, and clock generation such as a crystal oscillator. Means and / or input / output means such as an IO port, and the storage unit 41 is realized by a storage medium.

  The control unit 9 is connected to the pump 4 (specifically, the motor 17), the discharge-side pressure sensor 7, the input unit 10, and the alarm generation unit 11 through input / output means (not shown). The input unit 10 is, for example, an operation button attached to the main body 31 of the housing 8. In addition, the alarm generation unit 11 includes a speaker that generates a predetermined warning sound, and is attached to the main body unit 31.

  An output signal from the discharge side pressure sensor 7 is input to the pressure detection unit 35. Based on this output signal, the pressure detector 35 detects the maximum pressure P1 of the discharge side tube portion 27b during the intermittent operation of the pump 4. That is, as shown in FIG. 5, the pressure detection unit 35 detects the maximum value (peak value of the solid line L2 (L3)) of the output signal of the discharge side pressure sensor 7 during one intermittent operation as the maximum pressure P1. The detection result is output to the maximum pressure comparison unit 37.

  Moreover, the pressure detection part 35 detects the residual pressure of the discharge side tube part 27b after predetermined time progress from the time of detection of the maximum pressure P1. In this embodiment, as shown in FIG. 5, the pressure detection unit 35 detects the residual pressure P2 at the time of starting the next intermittent operation of the pump 4 (at the rise of the solid line L1), and the detection result is used as the residual pressure comparison unit. To 36. The pressure detection unit 35 may be incorporated in the discharge side pressure sensor 7.

  Based on the output result from the pressure detection unit 35, the residual pressure comparison unit 36 compares the residual pressure P2 of the discharge side tube portion 27b with a predetermined set residual pressure (20 Kpa in the example shown in FIG. 3), and compares this comparison. The result is output to the pump control unit 40. The set residual pressure is set based on, for example, the convergence pressure of the discharge side tube portion 27b after a sufficiently long time has elapsed after the drive of the pump 4 once, and is stored in the storage unit 41.

  Based on the output result from the pressure detection unit 35, the maximum pressure comparison unit 37 compares the maximum pressure P1 of the discharge side tube unit 27b with a predetermined set maximum pressure (for example, 150 Kpa), and performs alarm control on the comparison result. To the unit 38. The set maximum pressure is set based on each component of the infusion pump device 1 such as the infusion tube 5 and the pressure resistance of the catheter and the like, and is stored in the storage unit 41.

  The alarm control unit 38 determines whether or not the maximum pressure P1 exceeds the set maximum pressure based on the comparison result input from the maximum pressure comparison unit 37. When it is determined that the maximum pressure P1 exceeds the set maximum pressure, the catheter and the filter are in a closed state, and each component of the infusion pump device 1 such as the infusion tube 5 or the like has a pressure higher than the pressure resistance. Since this is applied, there is a risk that these structures may be damaged. Therefore, in this case, the alarm control unit 38 controls the alarm generation unit 11 so that the alarm generation unit 11 issues an alarm.

  The pump drive unit 39 is a motor drive circuit that drives the motor 17, and drives the pump 4 (specifically, the motor 17) based on a control command from the pump control unit 40.

  For example, information on the unit injection flow rate and the total injection amount (total amount of the chemical solution injected into the patient 3) input from the input unit 10 is input to the pump control unit 40. In this embodiment, the amount of the chemical liquid discharged by one intermittent drive of the pump 4 is constant. Therefore, the pump control unit 40 sets the driving pitch (driving time interval) of the pump 4 and the total number of driving times of the pump 4 based on the input information on the unit injection flow rate and the total injection amount. Then, based on the set drive pitch of the pump 4 and the total number of drive times of the pump 4, a drive command for the pump 4 is output to the pump drive unit 39. In addition, the chemical solution injection time to the patient 3 is calculated from the drive pitch of the pump 4 and the total number of times the pump 4 is driven, and the infusion pump device 1 stops when this chemical solution injection time elapses.

  Further, the pump control unit 40 determines whether or not the residual pressure P2 has decreased to the set residual pressure based on the comparison result input from the residual pressure comparison unit 36. When it is determined that the set residual pressure P2 has not decreased to the set residual pressure, it can be determined that the chemical solution to be injected into the patient 3 is not injected by one intermittent operation of the pump 4. Therefore, in this case, even if the pump 4 is driven by the driving pitch of the pump 4 and the total number of driving times of the pump 4 set based on the information of the unit injection flow rate and the total injection amount input from the input unit 10, a predetermined value is obtained. The total injection volume cannot be injected into patient 3.

  Therefore, in this embodiment, when the pump control unit 40 determines that the residual pressure P2 has not decreased to the set residual pressure, the pump control unit 40 increases the total number of times the pump 4 is set based on the determination result. That is, the pump control unit 40 increases the total number of times the pump 4 is driven to inject a predetermined total injection amount into the patient 3, thereby extending the time for injecting the chemical solution into the patient 3. For example, from the ratio between the residual pressure P2 and the set residual pressure, it can be estimated to what extent the injection amount of the chemical solution is insufficient in one intermittent operation of the pump 4. Therefore, the total number of driving of the pump 4 is increased so that the shortage can be injected into the patient 3 based on the estimation result. Then, the pump control unit 40 controls the pump 4 via the pump driving unit 39 based on the increased total number of driving times of the pump 4.

(Outline control of infusion pump device)
FIG. 6 is a flowchart showing a control flow related to the discharge of the chemical solution in the infusion pump device 1 shown in FIG. FIG. 7 is a flowchart showing a control flow related to detection of the residual pressure of the discharge side tube portion 27b and processing after detection of the residual pressure in the infusion pump device 1 shown in FIG.

  The outline of the control related to the discharge of the chemical solution in the infusion pump device 1 configured as described above, and the outline of the control related to the detection of the residual pressure of the discharge side tube portion 27b and the processing after the residual pressure detection are as follows. explain.

  When the infusion pump device 1 discharges the chemical solution and injects the chemical solution into the patient 3, first, necessary information (conditions) is input from the input unit 10 by the patient 3, a doctor, a nurse, or the like (step S1). ). For example, the unit injection flow rate and the total injection amount of the chemical solution are input. Thereafter, the pump control unit 40 sets the driving pitch of the pump 4 and the total number of times of driving of the pump 4 based on the input information on the unit injection flow rate and the total injection amount (step S2).

  When the setting of the drive pitch and the total number of times of driving is completed, the pump control unit 40 determines whether or not it is the start timing of the intermittent operation of the pump 4 (step S3), and when the start timing of the pump 4 comes, the pump control is performed. The unit 40 outputs a drive command for the pump 4 to the pump drive unit 39. Then, the pump 4 is activated and intermittently driven to pressurize and discharge the chemical solution (step S4).

  When the intermittent drive of the pump 4 is finished, the pump control unit 40 determines whether or not the drive of the pump 4 for the set total number of times of drive is finished (step S5). When the driving of the pump 4 for the set total number of times of driving is finished, the discharge control of the chemical solution in the infusion pump device 1 is finished, and the driving of the pump 4 for the set number of total driving times is not finished. Returns to step S3.

  Further, the process returns from step S5 to step S3, and if it is determined in step S3 that it is the start timing of the pump 4, according to the control flow shown in FIG. Perform post-detection processing.

  That is, first, the pressure detection unit 35 detects the residual pressure P2 of the discharge side tube portion 27b after a predetermined time has elapsed since the detection of the maximum pressure P1 of the discharge side tube portion 27b during the intermittent operation of the pump 4 (step S10). ). Specifically, as described above, the pressure detector 35 detects the residual pressure P2 of the discharge side tube portion 27b when the next pump 4 is started.

  The residual pressure comparison unit 36 compares the residual pressure P2 of the discharge side tube portion 27b with a predetermined set residual pressure based on the output result from the pressure detection unit 35, and outputs the comparison result to the pump control unit 40. At the same time, the pump control unit 40 determines whether or not the residual pressure P2 has decreased to the set residual pressure based on the comparison result input from the residual pressure comparison unit 36 (step S11).

  If the residual pressure P2 has decreased to the set residual pressure in step S11, the process of detecting the residual pressure of the discharge side tube portion 27b and the process after detecting the residual pressure is finished as it is. On the other hand, if the residual pressure P2 has not decreased to the set residual pressure in step S11, the pump control unit 40 resets the total number of times of driving to increase the set total number of times of driving of the pump 4 (step S12). After that, the detection flow of the discharge side tube portion 27b and the processing flow after the detection of the residual pressure are finished. When the total number of times of driving is reset, in step S5, it is determined whether or not the driving of the pump 4 having been reset is completed.

  In this embodiment, step S4 is a pump drive step for intermittently driving the pump 4 that pressurizes and discharges the chemical solution. In step S10, based on the output result from the discharge side pressure sensor 7, the discharge side tube portion 27b after a predetermined time has elapsed since the detection of the maximum pressure P1 of the discharge side tube portion 27b during intermittent driving of the pump 4. This is a residual pressure detecting step for detecting the residual pressure P2. Further, step S11 and step S12 are processing steps for performing a predetermined process based on the detection result of the residual pressure P2.

(Main effects of this form)
As described above, in the infusion pump device 1 of the present embodiment, the discharge side tube portion after a predetermined time has elapsed from the time when the maximum pressure P1 of the discharge side tube portion 27b is detected based on the output result from the discharge side pressure sensor 7. The residual pressure P2 of 27b is detected. As described above, it is possible to estimate whether or not the chemical liquid discharged from the pump 4 in one intermittent operation has been injected into the body of the patient 3 by detecting the residual pressure P2. Therefore, by detecting the residual pressure P2, it can be estimated whether or not a predetermined amount of the chemical solution is injected into the body of the patient 3.

  In this embodiment, a predetermined process is performed based on the detection result of the residual pressure P2. That is, the total number of times the pump 4 is driven is increased based on the estimation result as to whether or not a predetermined amount of the drug solution is injected into the body of the patient 3, thereby extending the drug solution injection time. Therefore, a predetermined amount of the chemical liquid sealed in the chemical liquid container 2 can be reliably (ie, accurately) injected into the patient 3. That is, in this embodiment, it is possible to accurately manage the injection amount of the chemical solution.

  In this embodiment, the residual pressure P2 at the time of starting the intermittent drive of the pump 4 is detected. Therefore, the amount of the chemical solution injected by one intermittent drive of the pump 4 can be estimated more appropriately. Therefore, the injection amount of the chemical solution can be managed with higher accuracy.

(Other embodiments)
The above-described embodiment is an example of a preferred embodiment of the present invention, but is not limited to this, and various modifications can be made without departing from the scope of the present invention.

  In the form mentioned above, when the residual pressure P2 has not fallen to the set residual pressure, the set total number of driving of the pump 4 is increased. In addition to this, for example, when the residual pressure P2 does not decrease to the set residual pressure, a warning display may be performed to notify that an abnormality has occurred in which the residual pressure P2 does not decrease to the set residual pressure. Hereinafter, a configuration for displaying a warning will be briefly described.

  When performing a warning display, as shown by a two-dot chain line in FIG. 4, the infusion pump device 1 includes a display unit 45 for displaying a change in the residual pressure P2. The display unit 45 is a liquid crystal panel, for example, and is attached to the main body unit 31. Moreover, the control part 9 is provided with the display control part 46 which controls the display part 45, as shown with the dashed-two dotted line of FIG. A comparison result between the residual pressure P2 and a predetermined set residual pressure is input from the residual pressure comparison unit 36 to the display control unit 46. The display control unit 46 determines whether or not the residual pressure P2 has decreased to the set residual pressure based on the comparison result input from the residual pressure comparison unit 36. When the display control unit 46 determines that the residual pressure P2 has not decreased to the set residual pressure, the display control unit 46 displays a warning on the display unit 45 based on the determination result.

  In the control related to the warning display, as shown in the control flow of FIG. 8, the display control unit 46 displays a warning on the display unit 45 instead of step S12 of FIG. 7 (step S22). In this case, step S11 and step S22 are processing steps for performing a predetermined process based on the detection result of the residual pressure P2.

  Further, when the residual pressure P2 has not decreased to the set residual pressure, an alarm may be generated informing that an abnormality has occurred in which the residual pressure P2 does not decrease to the set residual pressure. In this case, as shown by a two-dot chain line in FIG. 4, the comparison result between the residual pressure P2 and the predetermined set residual pressure is input to the alarm control unit 38 from the residual pressure comparison unit 36, and the alarm control unit 38 Based on the comparison result input from the residual pressure comparison unit 36, it is determined whether or not the residual pressure P2 has decreased to the set residual pressure. When the alarm control unit 38 determines that the residual pressure P2 has not decreased to the set residual pressure, the alarm control unit 38 causes the alarm generation unit 11 to generate an alarm based on the determination result. In the control related to such alarm generation, the alarm control unit 38 causes the alarm generation unit 11 to generate an alarm instead of step S22 of FIG. In this case, step S11 and the step of generating an alarm are processing steps for performing a predetermined process based on the detection result of the residual pressure P2.

  Further, when the residual pressure P2 is not reduced to the set residual pressure, a warning may be displayed and an alarm may be generated.

  As described above, when a warning is displayed and / or when an alarm is generated, the patient 3 itself, a doctor, a nurse, or the like is informed that a predetermined amount of the chemical is not injected into the patient 3 body. Can do. Therefore, the patient 3, a doctor, a nurse, or the like can take a predetermined treatment so that a predetermined amount of the chemical solution is injected based on the warning display or alarm. For example, a catheter or filter can be exchanged.

  It should be noted that the fact that the liquid that should be injected into the body of the patient 3 by the intermittent drive of the pump 4 is not injected does not have a fatal effect on the patient 3 and the infusion pump device 1. Therefore, when a warning is displayed instead of an alarm that is issued when the maximum pressure P1 exceeds the set maximum pressure, it is not necessary for the doctor or nurse to rush to the patient 3 in a hurry. Alternatively, by changing the alarm sound that is generated when the residual pressure P2 is not reduced to the set residual pressure and the alarm sound that is generated when the maximum pressure P1 exceeds the set maximum pressure, depending on the alarm sound, There is no need for a doctor or nurse to rush to the patient 3. As a result, it becomes possible to reduce the work load of a doctor or a nurse.

  Further, when the residual pressure P2 has not decreased to the set residual pressure, the drive pitch (intermittent drive interval) of the pump 4 is shortened so that more chemical liquid can be discharged from the pump 4 in a short time. good. In this case, the pump control unit 40 resets the drive pitch of the pump 4 instead of step S12 in FIG. In this case, based on the reset drive pitch, it is determined whether or not it is the start timing in step S3. In this case, step S11 and the step of resetting the drive pitch of the pump 4 are processing steps for performing a predetermined process based on the detection result of the residual pressure P2.

  Further, when the residual pressure P2 is not reduced to the set residual pressure, a warning display and / or alarm generation may be performed, and the chemical solution injection time may be extended and / or the driving pitch of the pump 4 may be shortened.

  In the form mentioned above, when the residual pressure P2 has not fallen to the setting residual pressure, the chemical | medical solution injection | pouring time to the patient 3 is extended by increasing the total frequency | count of driving of the pump 4. FIG. In addition to this, for example, the liquid injection time may be extended by increasing the drive pitch of the pump 4 without changing the total number of times the pump 4 is driven. As indicated by a broken line L4 in FIG. 3B, when the operation pitch of the pump 4 is long, the residual pressure P2 decreases to the set residual pressure. Therefore, by increasing the drive pitch of the pump 4, it becomes possible to reliably inject a predetermined amount of the drug solution sealed in the drug solution container 2 into the patient 3.

  In the form mentioned above, the pressure detection part 35 has detected the residual pressure P2 at the time of starting of the intermittent operation | movement of the pump 4 (at the time of the rising of the continuous line L1). In addition, for example, instead of the residual pressure P2 at the time of starting the pump 4, as shown in FIG. 9, the residual pressure P3 of the discharge side tube portion 27b after the predetermined time t0 has elapsed since the detection of the maximum pressure P1 is detected. May be. When the filter or the like is clogged, the residual pressure P3 of the discharge side tube portion 27b after the elapse of time t0 increases from the residual pressure P31 to the residual pressure P32 as shown in FIG. 9, for example. If the residual pressure increases to P32, it is estimated that the pressure in the discharge side tube portion 27b does not decrease to a predetermined pressure before the next intermittent start of the pump 4. Therefore, it is possible to estimate whether or not the chemical liquid to be injected into the patient 3 is injected by detecting the residual pressure P3 in the discharge side tube portion 27b after the elapse of time t0.

  In addition, as shown in FIG. 9, by detecting a decrease time t1 from when the pressure of the discharge side tube portion 27b reaches the maximum pressure P1 to when the pressure decreases to a predetermined reference pressure P0, it is injected into the patient 3. You may estimate whether the chemical | medical solution which should be injected is inject | poured. That is, if the drop time t1 is short, clogging of the filter or the like is not generated, and it is estimated that the chemical liquid discharged from the pump 4 is injected into the body of the patient 3. On the other hand, if the decrease time t1 is long, it is estimated that the drug solution discharged from the pump 4 stays in the infusion tube 5 and the like, and the discharged drug solution is not injected into the body of the patient 3. In this way, it is possible to estimate whether or not a predetermined amount of chemical solution is injected into the body of the patient 3 by detecting the decrease time t1. In this case, the control unit 9 includes a time detection unit (not shown) that detects the decrease time t1 based on the output result from the discharge side pressure sensor 7. The reference pressure P0 is stored in the storage unit 41, for example.

  In the above-described form, the total amount of the chemical liquid sealed in the chemical liquid container 2 is usually the total injection amount. However, the total injection amount may not be the total amount of the chemical liquid sealed in the chemical liquid container 2 but may be a partial amount of the chemical liquid sealed in the chemical liquid container 2.

  In the embodiment described above, the pump 4 is a finger-type pump including three fingers 14 to 16. In addition to this, for example, the pump 4 may be a roller pump including a plurality of rollers that press the infusion tube 5. The pump 4 may be another pump such as a diaphragm pump. In addition, when the pump 4 is a finger type pump as in the above-described embodiment, it is possible to accurately discharge a small amount of chemical liquid.

  In the above-described embodiment, the embodiment of the present invention has been described by taking the infusion pump device 1 for injecting a drug solution into the body of a patient (human) as an example. However, the configuration of the present invention is an animal (an animal other than a human). The present invention can also be applied to an infusion pump device for injecting a drug solution into the body.

It is a figure for demonstrating the schematic structure inside the infusion pump apparatus concerning embodiment of this invention. It is a graph which shows the relationship between the injection | pouring time of the chemical | medical solution inject | poured with the infusion pump apparatus shown in FIG. 1, and unit injection | pouring flow volume. It is a figure which shows the relationship between the injection | pouring time of the chemical | medical solution inject | poured with the infusion pump apparatus shown in FIG. 1, the pressure of a discharge side tube part, and the drive timing of a pump, (A) is the state which has not caused clogging of a filter (B) shows a state in which the filter is clogged. It is a block diagram which shows the outline of the control part of the infusion pump apparatus shown in FIG. 1, and its related apparatus. It is a graph which expands and shows the part corresponded to E section of Drawing 3 (A). It is a flowchart which shows the control flow relevant to discharge of the chemical | medical solution in the infusion pump apparatus shown in FIG. It is a flowchart which shows the control flow relevant to the process after detection of the residual pressure of the discharge side tube part in the infusion pump apparatus shown in FIG. 1, and residual pressure detection. It is a flowchart which shows the control flow relevant to the process after detection of the residual pressure of the discharge side tube part concerning other embodiment of this invention, and residual pressure detection. It is a figure for demonstrating the detection method of the residual pressure of the discharge side tube part concerning the other embodiment of this invention, and the detection method of the fall time of the pressure of a discharge side tube part.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Infusion pump apparatus 2 Chemical solution container 4 Pump 5 Infusion tube 7 Discharge side pressure sensor 9 Control part 10 Input part 11 Alarm generation part 27 1st infusion tube 27b Discharge side tube part 45 Display part P1 Maximum pressure P2 Residual pressure t1 Decrease time S4 Pump drive step S10 Residual pressure detection step S11 Part of processing step S12 Part of processing step S22 Part of processing step

Claims (7)

In an infusion pump device for injecting a medicinal solution sealed in a medicinal solution container into a human or animal body,
A pump that intermittently drives and pressurizes and discharges the chemical solution, an infusion tube through which the chemical solution passes, and a pressure of a discharge side tube portion of the infusion tube that is disposed on the discharge side of the pump is detected. And a discharge side tube part after a predetermined time has elapsed from the detection of the maximum pressure of the discharge side tube part during intermittent driving of the pump based on the output result from the discharge side pressure sensor And a control unit that performs a predetermined process based on the detection result of the residual pressure.   The infusion pump device according to claim 1, wherein the control unit detects the residual pressure at the time of starting intermittent driving of the pump. A display unit and / or an alarm generation unit for notifying the change of the residual pressure,
Based on the detection result of the residual pressure, the control unit performs a warning display on the display unit informing that an abnormality has occurred in which the residual pressure does not decrease to a predetermined set residual pressure, and / or the residual pressure. 3. The infusion pump device according to claim 1 or 2, wherein an alarm for notifying that an abnormality in which the pressure does not decrease to a predetermined set residual pressure has occurred is generated in the alarm generation unit.   The control unit controls the pump based on the detection result of the residual pressure so as to extend a chemical solution injection time required for injecting a predetermined amount of the chemical solution in the chemical solution container into the person or animal. The infusion pump device according to any one of claims 1 to 3, wherein the pump is controlled so as to shorten an interval of intermittent driving of the pump.   An input unit that inputs a unit injection flow rate that is an injection flow rate per unit time of the chemical solution and a total injection amount of the chemical solution; and the control unit is configured to input the unit injection flow rate and the total input amount that are input from the input unit. The total number of times that the pump is driven is set based on the injection amount, and the total number of times that the pump is driven is increased based on the detection result of the residual pressure, thereby extending the chemical solution injection time. 4. Infusion pump device. In an infusion pump device for injecting a medicinal solution sealed in a medicinal solution container into a human or animal body,
A pump that intermittently drives and pressurizes and discharges the chemical solution, an infusion tube through which the chemical solution passes, and a pressure of a discharge side tube portion of the infusion tube that is disposed on the discharge side of the pump is detected. The discharge side pressure sensor and the output result from the discharge side pressure sensor, when the pressure of the discharge side tube part reaches the maximum pressure during intermittent driving of the pump. An infusion pump device comprising: a controller that detects a decrease time until the pressure decreases to a predetermined pressure, and performs a predetermined process based on the detection result of the decrease time. In the control method of the infusion pump device for injecting the drug solution enclosed in the drug solution container into the human or animal body,
A pump driving step for intermittently driving a pump for pressurizing and discharging the chemical solution;
Based on the output result from the discharge-side pressure sensor for detecting the pressure of the discharge-side tube portion arranged on the discharge side of the pump of the infusion tube through which the chemical solution passes, the pump at the intermittent drive of the pump A residual pressure detecting step for detecting a residual pressure of the discharge side tube part after a predetermined time has elapsed since the maximum pressure detection of the discharge side tube part;
And a processing step of performing a predetermined process based on the detection result of the residual pressure detected in the residual pressure detection step.

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