JP2008298590A - Analyzing apparatus and reagent bottle management method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an analyzing apparatus capable of reducing overall burdens from the manufacturing of reagents and their use by reducing burdens on the side of reagent manufacturing factories in the case that reagents are managed through the use of RFID tags, and to provide a reagent managing method. <P>SOLUTION: In the case where the presence of two reagent bottles or more housing the same type of reagents of the same lot number is determined on the basis of manufacturing-side management information of read RFID tags 11c on the side of the analyzing apparatus 1, identifiable bottle numbers are written in the RFID tags 11c of the two reagent bottles or more to make the two reagent bottles or more identifiable. Since it is possible to omit the writing of serial numbers on the manufacturing side of reagents, it is possible to reduce burdens on the side of reagent manufacturing factories. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an analyzer for analyzing a sample using a reagent in a bottle and a management method for managing a reagent used for analysis.

  2. Description of the Related Art Conventionally, an analyzer that automatically analyzes a sample by dispensing a sample and a reagent into a reaction vessel and optically detecting a reaction occurring in the reaction vessel is known. In such an analyzer, since it is necessary to store and manage a plurality of reagents in the reagent storage according to the measurement item, an RFID tag in which reagent information is recorded is attached to each reagent bottle (for example, Patent Document 1). For example, a method has been proposed in which the reagent contained in each reagent bottle is managed by reading an RFID tag via a radio wave having a predetermined frequency.

  In order to manage the reagent using the RFID tag, first, the reagent manufacturing factory side uses the RFID tag with a reagent type, an analysis item to be used, an expiration date of the reagent, a reagent bottle type, a lot number, and a different number for each reagent bottle. A serial number is written as reagent information. Then, the analyzer reads the reagent information in the RFID tag attached to the reagent bottle, and recognizes and analyzes the reagent contained in each reagent bottle based on the reagent type and use analysis item read from the RFID tag. Reagents used for processing are selected, the expiration date of each reagent is confirmed based on the expiration date read from the RFID tag, and the remaining amount of reagent in the reagent bottle is managed based on the reagent bottle type read from the RFID tag. The calibration processing is controlled based on the lot number read from the RFID tag.

  Here, in the analyzer, a plurality of reagent bottles of the same type are often stored in the same reagent storage for reagents used for analysis items with a large number of requests. In such a case, the analyzer uses the serial number written in the RFID tag as reagent information on the reagent manufacturing factory side to distinguish between the plurality of reagent bottles of the same type accommodated in the same reagent storage. .

JP 2006-153524 A

  However, this serial number is used for discriminating the same kind of reagent bottle at the time of use, and is not necessarily information necessary for management until the reagent is manufactured and shipped. Nevertheless, on the reagent manufacturing factory side, shipment was possible only after the complicated process of writing the serial number with a different number for each reagent bottle into each RFID tag was completed. For this reason, conventionally, the burden of RFID writing processing on the reagent manufacturing factory side has been great.

  The present invention has been made in view of the above-described drawbacks of the prior art, and reduces the burden on the reagent manufacturing factory side when reagent management is performed using RFID tags, and thus the entire process from reagent manufacture to use. It is an object of the present invention to provide an analyzer and a reagent management method that can realize a practical load reduction.

  In order to solve the above-described problems and achieve the object, an analyzer according to the present invention is an analyzer that analyzes a sample using a reagent in a bottle, and is attached to the bottle via radio waves of a predetermined frequency. An information storage medium capable of communicating with the outside and storing the type and lot information of the reagent in the bottle as manufacturing side management information, and the manufacturing side management stored in the information storage medium via the radio wave of the predetermined frequency Reading means for reading information, writing means for writing apparatus-side management information corresponding to the reagent in the bottle to the information storage medium via radio waves of the predetermined frequency, and manufacturing-side management information read by the reading means If it is determined that there are two or more bottles containing reagents with the same type and lot information, two or more bottles containing reagents with the same type and lot information are stored. Bottle information that can be identified with respect to the information storage medium of each bottle is written in the writing means as the apparatus-side management information, and manufacturing-side management information stored in the information storage medium attached to each bottle, and And / or control means for managing the reagent in each bottle using the apparatus-side management information.

  Further, in the analyzer according to the present invention, the control means uses the manufacturing side management information and the bottle information for the reagents in two or more bottles containing the reagents having the same type and lot information. The reagent in the other bottles is managed using the manufacturing side management information.

  The analyzer according to the present invention further includes a moving means for storing a plurality of the bottles and moving the bottles to be dispensed to a reagent suction position, and the reading means includes the moving process of the moving means. Read according to the information storage medium of the bottle that is provided according to the movement path of the bottle and moves on the movement path, and the writing means is provided according to the movement path and moves on the movement path Information is written in the information storage medium of the bottle.

  In the analyzer according to the present invention, the information storage medium is attached to the upper surface of the bottle, the bottom surface of the bottle, or the side surface of the bottle, and the reading unit and the writing unit move on the moving path. It is provided in the position which can be approached with the information recording medium attached | subjected to the said bottle.

  The analyzing apparatus according to the present invention is characterized in that a plurality of the reading means and the writing means are arranged corresponding to each of the plurality of bottles.

  The management method according to the present invention is a management method for managing a reagent used for analysis. The management method is attached to a bottle and is capable of communicating with the outside via radio waves of a predetermined frequency, and the type of reagent in the bottle and A reading step for reading the manufacturing side management information from an information storage medium storing lot information as manufacturing side management information, and a reagent of the same type and lot information based on the manufacturing side management information read in the reading step. If it is determined that there are two or more bottles containing a reagent having the same type and lot information in the determination step, and determining whether there are two or more bottles stored, the type and lot information is A writing step for writing identifiable bottle information to information storage media of two or more bottles containing the same reagent. And flop, characterized in that it comprises a and a management step of managing the reagent in each bottle by using a manufacturing-side management information and / or device-side management information in the information storage medium.

  Further, in the management method according to the present invention, the management step uses the manufacturing side management information and the bottle information for reagents in two or more bottles containing reagents having the same type and lot information. The reagent in the other bottles is managed using the manufacturing side management information.

  According to the present invention, when the analyzer side determines that there are two or more bottles containing reagents of the same type and lot information based on the manufacturing side management information in the read information storage medium, By writing bottle information that can be identified on the information storage medium of the two or more bottles so that the two or more bottles can be identified, writing of serial information on the reagent manufacturing side can be omitted. Therefore, it is possible to reduce the burden on the reagent manufacturing factory side, and to reduce the overall load from reagent manufacture to use.

  Hereinafter, with reference to the drawings, an analyzer that is an embodiment of the present invention will be described by way of example of an analyzer that performs biochemical analysis on a sample such as blood or urine. Note that the present invention is not limited to the embodiments. In the description of the drawings, the same parts are denoted by the same reference numerals.

  FIG. 1 is a schematic diagram illustrating a configuration of an analyzer according to an embodiment. As shown in FIG. 1, the analyzer 1 according to the embodiment dispenses a specimen and a reagent to be analyzed into a reaction vessel 21 and optically measures a reaction occurring in the reaction vessel 21. And a control mechanism 3 that controls the entire analyzer 1 including the measurement mechanism 2 and analyzes the measurement result in the measurement mechanism 2. The analyzer 1 automatically and sequentially performs biochemical analysis for detecting the concentration of the detection target in the sample by the cooperation of these two mechanisms.

  First, the measurement mechanism 2 will be described. The measurement mechanism 2 is roughly divided into a reaction table 10, a first reagent storage 11, a first reagent dispensing mechanism 12, a sample transfer unit 13, a sample dispensing mechanism 14, a second reagent storage 15, a second reagent dispensing mechanism 16, A stirring unit 17, a photometric unit 18, and a cleaning unit 19 are provided.

  The reaction table 10 transfers the reaction container 21 to a predetermined position in order to dispense a sample or reagent into the reaction container 21, to stir, wash or measure the reaction container 21. The reaction table 10 is rotatable about a vertical line passing through the center of the reaction table 10 as a rotation axis by driving a drive mechanism (not shown) under the control of the control unit 31. An openable and closable lid and a thermostat (not shown) are provided above and below the reaction table 10, respectively.

  The first reagent storage 11 can store a plurality of first reagent bottles 11 a in which the first reagent dispensed first among the two types of reagents dispensed in the reaction container 21 is accommodated. A plurality of storage chambers are arranged at equal intervals in the first reagent storage 11, and the first reagent bottle 11a is detachably stored in each storage chamber. For example, the first reagent storage 11 rotates clockwise or counterclockwise with a vertical line passing through the center of the first reagent storage 11 as a rotation axis when a drive mechanism (not shown) is driven under the control of the control unit 31. The first reagent bottle 11a that is movable and that is to be dispensed is moved to the reagent aspirating position by the first reagent dispensing mechanism 12. An openable / closable lid (not shown) is provided above the first reagent storage 11. The first reagent storage 11 is kept cold. Therefore, when the first reagent bottle 11a is stored in the first reagent storage 11 and the lid is closed, the reagent stored in the first reagent bottle 11a is kept in a cold state, and the first reagent bottle 11a Evaporation and denaturation of the reagent contained in the container can be suppressed.

  An RFID tag 11c that stores reagent information related to the reagent stored in the first reagent bottle 11a is attached to the side surface of the first reagent bottle 11a on the outer periphery side of the first reagent container 11. The RFID tag is a tag-shaped information storage medium used in an RFID (Radio Frequency Identification) system. Various kinds of information stored in the RFID tag 11c can be read and written and rewritten via radio waves having a predetermined frequency for instructing writing and reading. The RFID tag 11c includes, as manufacturing side management information, a manufacturer code indicating a manufacturer, an item code indicating an analysis item to be used, a bottle type indicating a reagent bottle size, one of the first reagent and the second reagent, and a reagent. The reagent type indicating the type, the expiration date of the reagent, and the lot number are written on the reagent manufacturing factory side. When it is determined in the analyzer 1 that there are two or more first reagent bottles 11a containing reagents of the same type and lot number, the two RFID tags 11c of the two or more bottles are identified by the two. A bottle number that can identify each bottle is written as apparatus-side management information. The RFID tag 11c has manufacturing side management information and apparatus side management information, as well as the reagent start time in the first reagent bottle 11a to which the RFID tag 11c is attached, and the reagent remaining amount in the first reagent bottle 11a. The progress information generated by using the reagent may be stored.

  A first reagent reader / writer 11 b for reading and writing the RFID tag 11 c is provided on the outer periphery of the first reagent storage 11. Under the control of the control unit 31, the first reagent reader / writer 11b reads manufacturing-side management information, device-side management information, and the like stored in the RFID tag 11c via radio waves of a predetermined frequency, and the first reagent The apparatus-side management information corresponding to the reagent in the bottle 11a is written in the RFID tag 11c attached to the first reagent bottle 11a. The first reagent reader / writer 11b is provided according to the movement path of the first reagent bottle 11a accompanying the movement process of the first reagent storage 11, and moves on the movement path so as to be communicable with the RFID tag 11c. The RFID tag 11c attached on the first reagent bottle 11a is provided at a position close to the first reagent bottle 11a. The first reagent reader / writer 11b reads information from the RFID tag 11c of the first reagent bottle 11a that moves on the moving path, and also sends information to the RFID tag 11c of the first reagent bottle 11a that moves on the moving path. Write.

  The first reagent dispensing mechanism 12 includes an arm 12a to which a probe for aspirating and discharging the first reagent is attached to the tip. The arm 12a freely moves up and down in the vertical direction and rotates around the vertical line passing through its base end as a central axis. The first reagent dispensing mechanism 12 includes an intake / exhaust mechanism using an unillustrated intake / exhaust syringe. The first reagent dispensing mechanism 12 sucks the reagent in the first reagent bottle 11a corresponding to the analysis item designated by the sample to be analyzed moved to the reagent suction position on the first reagent storage 11 into the probe. Then, the arm 12a is rotated clockwise in the figure, and dispensed into the reaction container 21 conveyed to the reagent discharge position on the reaction table 10.

  The sample transfer unit 13 includes a plurality of sample racks 13b that hold a plurality of sample containers 13a containing liquid samples such as blood and urine and sequentially transfer them in the direction of the arrows in the figure. The sample in the sample container 13a transferred to a predetermined position on the sample transfer unit 13 is dispensed by the sample dispensing mechanism 14 into the reaction container 21 that is arranged and transported on the reaction table 10.

  Similar to the first reagent dispensing mechanism 12, the sample dispensing mechanism 14 includes an arm 14 a to which a probe for aspirating and discharging a sample is attached at the tip, and an intake / exhaust mechanism using an unillustrated intake / exhaust syringe. The sample dispensing mechanism 14 sucks the sample into the probe from the sample container 13a transferred to the predetermined position on the sample transfer unit 13, and dispenses the sample by rotating the arm 14a counterclockwise in the drawing. To do.

  The second reagent storage 15 can store a plurality of second reagent bottles 15a in which the second reagent to be dispensed after the sample is dispensed among the two types of reagents dispensed in the reaction container 21 is accommodated. Similar to the first reagent storage 11, the second reagent storage 15 is provided with a plurality of storage chambers in which the second reagent bottles 15a are detachably stored. Similar to the first reagent storage 11, the second reagent storage 15 can be rotated clockwise or counterclockwise, and the desired second reagent bottle 15a is moved to the reagent suction position by the second reagent dispensing mechanism 16. To do. Similar to the first reagent bottle 11a, the RFID tag 15c in which manufacturing side management information and apparatus side management information related to the second reagent stored in the second reagent bottle 15a are recorded on the side surface of the second reagent bottle 15a. Is attached. As in the RFID tag 11c, manufacturing side management information is written in the RFID tag 15c on the reagent manufacturing factory side. When it is determined in the analyzer 1 that there are two or more second reagent bottles 15a containing reagents of the same type and lot number, the two RFID tags 15c of the two or more bottles are identified by the two. A bottle number that can identify each bottle is written as apparatus-side management information. The second reagent reader 15 has a function similar to that of the first reagent reader / writer 11b on the outer periphery of the second reagent container 15, and reads and writes information on the RFID tag 15c attached to the second reagent bottle 15a. A writer 15b is provided.

  Similarly to the first reagent dispensing mechanism 12, the second reagent dispensing mechanism 16 is an intake / exhaust mechanism using an arm 16a having a probe for aspirating and discharging the second reagent attached to the tip, and an unillustrated intake / exhaust syringe. The reagent in the second reagent bottle 15a corresponding to the analysis item instructed to the sample to be analyzed that has been moved to the reagent suction position on the second reagent storage 15 is sucked into the probe and then on the reaction table 10. To the reaction container 21 transported to the reagent discharge position. The stirring unit 17 stirs the first reagent, the sample, and the second reagent dispensed in the reaction vessel 21 to promote the reaction.

  The photometry unit 18 emits light of a predetermined wavelength to the reaction vessel 21 and receives the light that has passed through the reaction liquid of the reagent and the sample in the reaction vessel 21 to measure the spectral intensity. The measurement result obtained by the photometry unit 18 is output to the control unit 31 and analyzed by the analysis unit 34.

  The cleaning unit 19 performs cleaning by sucking and discharging the liquid mixture in the reaction vessel 21 that has been measured by the photometry unit 18 by using a nozzle (not shown) and injecting and sucking cleaning liquid such as detergent and cleaning water. . The washed reaction vessel 21 is reused. Depending on the contents of the inspection, the reaction vessel 21 may be discarded after completion of one measurement, and a new reaction vessel 21 may be automatically supplied although not shown.

  Next, the control mechanism 3 will be described. The control mechanism 3 includes a control unit 31, an input unit 33, an analysis unit 34, a storage unit 35, an output unit 36, and a transmission / reception unit 37. These units included in the measurement mechanism 2 and the control mechanism 3 are electrically connected to the control unit 31.

  The control unit 31 is configured using a CPU or the like, and controls processing and operation of each unit of the analyzer 1. The control unit 31 performs predetermined input / output control on information input / output to / from each of these components, and performs predetermined information processing on this information.

  The input unit 33 is configured by using a keyboard, a mouse, and the like, and acquires various information necessary for analyzing the sample, instruction information for the analysis operation, and the like from the outside. The analysis unit 34 obtains the concentration of the detection target in the sample based on the measurement result by the photometry unit 18, and performs component analysis of the sample. The storage unit 35 is configured using a hard disk that magnetically stores information and a memory that loads various programs related to the process from the hard disk and electrically stores them when the analyzer 1 executes the process. Various information including the analysis result of the sample is stored. The storage unit 35 may include an auxiliary storage device that can read information stored in a storage medium such as a CD-ROM, a DVD-ROM, or a PC card. The output unit 36 is configured using a display, a printer, a speaker, and the like, and outputs various information including the analysis result of the sample. The transmission / reception unit 37 has a function as an interface for transmitting / receiving information according to a predetermined format via a communication network (not shown).

  The control unit 31 includes a reagent management unit 32 that manages the reagents in the reagent bottles installed in the analyzer 1. The reagent management unit 32 uses the manufacturing-side management information and / or the apparatus-side management information in the RFID tags 11c and 15c attached to the first reagent bottle 11a and the second reagent bottle 15a, respectively. And the reagent in each 2nd reagent bottle 15a is managed.

  In order to manage the reagent, the reagent management unit 32 first has the same type and lot number based on the manufacturing side management information read by the first reagent reader / writer 11b and the second reagent reader / writer 15b. It is determined whether there are two or more bottles containing the reagent in the analyzer 1.

  Next, a case will be described in which the reagent management unit 32 determines that there are two or more bottles containing reagents of the same type and lot number in the analyzer 1. Specifically, as shown in FIG. 2, the reagent bottles 111a and 112a having the same lot number are stored in the same first reagent storage 11 together with the manufacturer code, item code, bottle type, reagent type, and reagent expiration date. This is the case.

  In this case, since the manufacturer code, item code, bottle type, reagent type, reagent expiration date, and lot number stored as the manufacturing management information are all the same, the reagent management unit 32 determines the reagent bottles 111a and 112a according to the manufacturing management information. Cannot be identified. Therefore, the reagent management unit 32 uses the bottle numbers that can be identified for the information storage media of the two or more bottles as device-side management information in the first reagent reader / writer 11b and the second reagent reader / writer 15b. Write to allow the two or more bottles to be identified. For example, the reagent management unit 32 causes the first reagent reader / writer 11b to write the bottle number “1” in the RFID tag 111c attached to the reagent bottle 111a as shown by the arrow Y1 in FIG. As indicated by the arrow Y2 of 2, the bottle number “2” is written in the RFID tag 112c attached to the reagent bottle 112a. Then, the reagent management unit 32 writes the reagents in the two or more reagent bottles 111a and 112a containing the reagents of the same type and lot information, together with the manufacturing side management information, to the RFID tags 111c and 112c, respectively. Each reagent bottle 111a, 112a is identified and managed using the bottle number “1” or “2”.

  A case will be described in which the reagent management unit 32 determines that there are not two or more bottles containing reagents of the same type and lot number in the analyzer 1. Specifically, as shown in FIG. 3, the first reagent bottle 113a in which the manufacturer code, the item code, the bottle type, the reagent type, and the reagent expiration date are the same, but the reagents of different lots with different lot numbers are accommodated. , 114 a are stored in the same first reagent storage 11.

  In this case, since the lot numbers are different among the pieces of information stored as the manufacturing management information, the reagent management unit 32 uses the RFID attached to the first reagent bottles 113a and 114a as indicated by arrows Y3 and Y4 in FIG. The bottle number is not written to the tag 113c. This is because the reagent management unit 32 can identify the first reagent bottles 113a and 114a by this lot number. The reagent management unit 32 uses the manufacturing side management information stored in the RFID tag 11c for the reagents in the reagent bottles other than the two or more reagent bottles containing the reagents of the same type and lot information. Identify and manage each reagent bottle.

  Here, with respect to the reagent used in the conventional analyzer, a serial number is used for distinguishing a plurality of reagent bottles of the same type at the time of use. For this reason, the reagent used in the conventional analyzer has the same manufacturer code, item code, bottle type, reagent type, reagent expiration date, and lot number, as indicated by the arrow Y10 in FIG. Even so, it was necessary to change the serial number for each reagent bottle and write it. Specifically, as shown in FIG. 4, from the reader / writer 104 installed in the reagent manufacturing factory, instruction radio waves DA11-15 including serial numbers different from each other for each RFID tag 110c attached to each reagent bottle 110a. Each RFID tag 110c must be written to the corresponding RFID tag 110c, and writing processing must be performed on each RFID tag 110c. This serial number is used for identification when the reagent is used in the analyzer, and is not necessarily required for management until the reagent is manufactured and shipped. In spite of that, since it could only be shipped after finishing the complicated process of writing the serial number with a different number to the corresponding RFID tag, the burden of the RFID manufacturing process on the reagent manufacturing factory side is great. It was.

  On the other hand, in the analyzer 1, each reagent is used as it is with respect to the reagent in the reagent bottle containing the reagent whose one of the manufacturing side management information read from the RFID tags 11c and 15c is different. For the reagents in two or more reagent bottles that identify the reagents in the bottles and store the same reagent on the manufacturing side, the bottles are stored in the RFID tags 11c and 15c of the bottles that store the reagents. After the number is written, the reagent in each reagent bottle is identified using the bottle number and the apparatus side management information.

  Accordingly, as illustrated in FIG. 5, the reagent used in the analyzer 1 is supplied from the reader / writer 4 with the manufacturer code, item code, bottle type, reagent type, reagent expiration date, and lot number as shown in FIG. It is sufficient to write six types of information as manufacturing side management information in the RFID tag 11c attached to each first reagent bottle 11a. That is, for the reagent used in the analyzer 1, it is not necessary to write a serial number for distinguishing each reagent bottle in the reagent manufacturing factory. Therefore, for the reagents used in the analyzer 1, only information that is essential between the production and shipment is information that essentially indicates the reagent itself, such as the reagent type, the amount of reagent contained, and the lot number. If data is written by the reader / writer 4, it can be shipped from the reagent manufacturing factory. Especially for reagent bottles containing reagents of the same lot, information with exactly the same manufacturer code, item code, bottle type, reagent type, reagent expiration date and lot number is written as device-side management information, enabling batch writing. In some cases, as shown by the arrow Y5, the device-side management information writing process can be completed by only issuing the instruction radio wave D1 for instructing writing to the plurality of RFID tags 11c from the reader / writer 4 once.

  As described above, with respect to the reagent used for the analyzer 1, the serial number writing for bottle identification at the time of use on the reagent manufacturing side can be omitted, so the burden on the reagent manufacturing factory side can be reduced.

  Further, in the analysis apparatus 1, the bottle number is written in the RFID tags 11c and 15c only for the reagent bottles in which the reagent in each reagent bottle cannot be identified by the manufacturing side management information read from the RFID tags 11c and 15c. The bottle can be identified. In other words, the analyzer 1 performs the bottle number writing process only when necessary. For this reason, according to the analyzer 1, since the burden of reagent management at the time of reagent use can be reduced as compared with the case where the bottle numbers are written for all the bottles, the entire process from the manufacture of the reagent to the use thereof can be reduced. Load reduction can be realized.

  Next, with reference to FIG. 6, the reagent identification process in the analyzer 1 will be described. As shown in FIG. 6, when the control unit 31 determines that a new reagent bottle is installed in the analyzer 1 (step S2), the reagent management unit 32 uses the first reagent reader / writer 11b and the second reagent use. A tag information reading process is performed for causing the reader / writer 15b to read apparatus-side management information in the RFID tags 11c and 15c of all the reagent bottles in the reagent container in which the reagent bottle is newly installed (step S4). In this case, the first reagent reader / writer 11b and the second reagent reader / writer 15b read at least the manufacturer code, item code, bottle type, reagent type, reagent expiration date, and lot number in each RFID tag 11c, 15c. It ’s enough.

  Then, the reagent management unit 32 determines whether or not there are two or more reagent bottles having the same lot number in the reagent of the type to be confirmed based on the management information of each device read from the RFID tags 11c and 15c. Judgment is made (step S6). When the reagent management unit 32 determines that there are two or more reagent bottles having the same lot number (step S6: Yes), the reagent management unit 32 applies each of these to the first reagent reader / writer 11b and the second reagent reader / writer 15b. A bottle number writing process for writing different bottle numbers to the RFID tags 11c and 15c attached to the reagent bottles is performed (step S8).

  Next, when the reagent management unit 32 determines that there are not two or more reagent bottles having the same lot number (step S6: No), or when the bottle number writing process (step S8) ends, all types of reagent bottles are displayed. It is determined whether the lot number has been confirmed for the reagent (step S10). If the reagent management unit 32 determines that the lot number has not been confirmed for all types of reagents (step S10: No), the process proceeds to step S6, and the lot number is the same for the type of reagent to be confirmed. It is determined whether there are two or more reagent bottles. On the other hand, when it is determined that the lot number has been confirmed for all types of reagents (step S10: Yes), the reagent management unit 32 displays the manufacturing side management information and / or the apparatus side management information in the RFID tags 11c and 15c. The use management of the reagent in the reagent bottle is carried out (step S12).

  The reagent identification process in the analyzer 1 is performed every time a reagent bottle is newly installed in the analyzer 1. In the reagent identification process in the analyzer 1, when a reagent bottle that has been used halfway in another apparatus and has a bottle number already written in the RFID tags 11c and 15c is newly set Even if there are other reagent bottles with the same manufacturer code, item code, bottle type, reagent type, reagent expiration date, and lot number, the bottle number in the RFID tag of this bottle is assigned to the new bottle. Since the number is rewritten, each reagent bottle can be appropriately identified.

  In the analyzer 1, progress information generated by the use of the reagent such as the reagent use start time and the reagent remaining amount in the reagent bottle is written in the RFID tags 11c and 15c as needed, and the reagent in the reagent bottle is used every time the reagent is used. It may be possible to further optimize the use of the reagent by determining whether the remaining amount of the reagent or the expiration date has expired.

  In FIG. 1, RFID tags 11 c and 15 c are attached to the side surfaces of the reagent bottles, and the first reagent reader / writer 11 b and the second reagent reader are arranged on the outer periphery of the first reagent container 11 and the second reagent container 15. Although the case where the writer 15b is provided has been described as an example, the present invention is not limited to this. For example, as illustrated in FIG. 7, the RFID tag 11c is attached to the bottom surface of the first reagent bottle, the first reagent reader / writer 11b is provided at the lower part of the first reagent storage 11, and the RFID tags 11c and 15c are read and written. May be performed. In this case, the first reagent reader / writer 11b is an area corresponding to the movement path of the first reagent bottle 11a, and a position where the first reagent bottle 11a can approach the RFID tag 11c of the first reagent bottle 11a that is moved by the rotation process of the reagent table 11e. Should be provided.

  Further, as illustrated in FIG. 8 which is a schematic sectional view of another example of the first reagent storage 11, an RFID tag 11c is attached to the upper surface of the first reagent bottle 11a to cover the inside of the first reagent storage 11. The first reagent reader / writer 11b may be provided on the lower surface of the lid 11d to read / write data from / to the RFID tags 11c and 15c. In this case, the first reagent reader / writer 11b is an area corresponding to the movement path of the first reagent bottle 11a arranged on the rotating reagent table 11e, and moves by the rotation process of the reagent table 11e. It may be provided at a position close to the RFID tag 11c of 11a.

  Moreover, as shown in FIG. 9, the analyzer 1 may include a measurement mechanism 202 provided with a reagent storage 211 that can store a plurality of reagent bottles 211a in a state of being arranged in two rows in a straight line. The reagent bottle 211a has a rectangular planar shape. As shown in FIG. 10, which is a schematic sectional view of the reagent storage 211, an RFID tag 11c is attached to the upper surface of the reagent bottle 211a. Then, as shown in FIGS. 9 and 10, the reagent dispensing mechanism 220 that aspirates the reagent from these reagent bottles 211a dispenses the reagent to the arm portion 223 that rotates in the horizontal direction around the support shaft 221. A probe 225 is provided. The arm part 223 has a first arm 223a whose one end is connected to the support shaft 221, a second arm 223b whose one end is connected to the other end of the first arm 223a, and one end connected to the other end of the second arm 223b. The third arm 223c is provided, and the probe 225 and the first reagent reader / writer 11b are provided on the other end side of the third arm 223c.

  In this arm portion 223, the first arm 223a and the second arm 223b are angularly displaced, whereby the probe 225 of the third arm 223c is moved above each reagent hole 211f provided in the lid 211d of the reagent storage 211. The first reagent reader / writer 11 b disposed on the third arm 223 c can be opposed to the RFID tag 11 c provided on the upper surface of each reagent bottle 211 a stored in the reagent storage 211. The control unit 31 controls the operation of the arm unit 223, and the RFID tag provided on the upper surface of the reagent bottle 211a in which the first reagent reader / writer 11b disposed in the third arm 223c is stored in the reagent storage 211 The information in the RFID tag 11c is read and the information is written in the RFID tag 11c by sequentially facing the 11c. 9 and 10, the example up to the third arm has been described, but the one up to the second arm may be used if necessary.

  A plurality of reader / writers that read the RFID tags attached to the reagent bottles may be arranged corresponding to each reagent bottle. Specifically, as illustrated in FIG. 11, reagent reader / writers 111 b to 116 b respectively corresponding to the reagent bottles 111 a to 116 a stored in the storage chambers of the first reagent storage 11 are arranged. In this case, the reagent reader / writer 111b reads and writes information on the RFID tag 111c attached to the reagent bottle 111a, and the reagent reader / writer 112b reads information on the RFID tag 112c attached to the reagent bottle 112a. The reagent reader / writer 113b reads and writes information on the RFID tag 113c attached to the reagent bottle 113a, and the reagent reader / writer 114b reads information on the RFID tag 114c attached to the reagent bottle 114a. The reagent reader / writer 115b reads and writes information on the RFID tag 115c attached to the reagent bottle 115a, and the reagent reader / writer 116b reads the reagent bottle 116. Reading and writing information to the RFID tag 116c attached to.

  The analysis apparatus 1 described in the above embodiment can be realized by executing a program prepared in advance on a computer system. This computer system implements the processing operation of the analyzer by reading and executing a program recorded on a predetermined recording medium. Here, the predetermined recording medium is not only a “portable physical medium” such as a flexible disk (FD), a CD-ROM, an MO disk, a DVD disk, a magneto-optical disk, and an IC card, but also inside and outside the computer system. It includes any recording medium that records a program readable by a computer system, such as a “communication medium” that holds the program in a short time when transmitting the program, such as a hard disk drive (HDD) provided. In addition, this computer system obtains a program from a management server or another computer system connected via a network line, and executes the obtained program to realize the processing operation of the analyzer.

It is a schematic diagram which shows the principal part structure of the analyzer concerning Embodiment. It is a figure explaining the bottle number assignment | providing process in the analyzer shown in FIG. It is a figure explaining the bottle number assignment | providing process in the analyzer shown in FIG. It is a figure explaining the write-in process to the RFID tag of the reagent bottle used for the conventional analyzer. It is a figure explaining the write-in process to the RFID tag of the reagent bottle used for the analyzer shown in FIG. It is a flowchart which shows the process sequence of the reagent identification process in the analyzer shown in FIG. It is a schematic diagram which shows the other example of the principal part of the reagent storage shown in FIG. It is sectional drawing which shows the other example of the principal part of the reagent storage shown in FIG. It is a perspective view explaining the other example of the measurement mechanism shown in FIG. It is sectional drawing of the principal part of the reagent storage shown in FIG. It is a figure explaining the other example of arrangement | positioning of the reader / writer for reagents shown in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Analyzer 2 Measurement mechanism 3 Control mechanism 4 Reader / writer 10 Reaction table 11 1st reagent storage 11a 1st reagent bottle 11b 1st reagent reader / writer 11c, 15c, 111c-116c RFID tag 11d Lid 11e Reagent table 12 1st Reagent dispensing mechanism 12a, 14a, 16a Arm 13 Sample transfer unit 13b Sample rack 13a Sample container 14 Sample dispensing mechanism 15 Second reagent storage 15a Second reagent bottle 15b Second reagent reader / writer 16 Second reagent dispensing mechanism 17 Stirring unit 18 Photometric unit 19 Washing unit 21 Reaction vessel 31 Control unit 32 Reagent management unit 33 Input unit 34 Analysis unit 35 Storage unit 36 Output unit 37 Transmitter / receiver unit 104 Reader / writer 220 Reagent dispensing mechanism 211 Reagent chamber 211a Reagent bottle 211d Lid 211f Each reagent hole 221 Support shaft 223 Arm unit 225 Probe 111a to 116a Reagent bottle 111b to 116b Reagent reader / writer

Claims (7)

In an analyzer that analyzes a sample using a reagent in a bottle,
An information storage medium attached to the bottle, capable of communicating with the outside via radio waves of a predetermined frequency, and storing the reagent type and lot information in the bottle as manufacturing side management information;
Reading means for reading manufacturing-side management information stored in the information storage medium via radio waves of the predetermined frequency;
Writing means for writing apparatus-side management information corresponding to the reagent in the bottle to the information storage medium via the radio wave of the predetermined frequency;
When it is determined that there are two or more bottles containing the reagent of the same type and lot information based on the manufacturing side management information read by the reading means, the reagent of the same type and lot information is stored The bottle information that can be identified for the information storage media of two or more bottles is written in the writing means as the apparatus-side management information, and the manufacturing-side management stored in the information storage medium attached to each bottle Control means for managing the reagent in each bottle using information and / or apparatus-side management information;
An analyzer characterized by comprising:   The control means manages the reagent in two or more bottles containing the reagent of the same type and lot information using the manufacturing side management information and the bottle information, and the reagent in the other bottle The analysis apparatus according to claim 1, wherein management is performed using the manufacturing side management information. It further comprises a moving means for storing a plurality of the bottles and moving a bottle to be dispensed to a reagent suction position,
The reading means is provided according to the movement path of the bottle accompanying the movement process of the moving means, reads information from an information storage medium of the bottle moving on the movement path,
The analyzer according to claim 1, wherein the writing unit writes information in an information storage medium of the bottle that is provided according to the movement path and moves on the movement path. The information storage medium is attached to the bottle upper surface, the bottle bottom surface or the bottle side surface,
The analyzer according to claim 3, wherein the reading unit and the writing unit are provided at positions that can approach the information recording medium attached to the bottle that moves on the moving path.   The analyzer according to claim 1 or 2, wherein a plurality of the reading means and the writing means are arranged corresponding to each of the plurality of bottles. In a management method for managing reagents used for analysis,
A reading step of reading the manufacturing side management information from an information storage medium attached to the bottle and capable of communicating with the outside via radio waves of a predetermined frequency and storing the reagent type and lot information in the bottle as manufacturing side management information When,
A determination step of determining whether or not there are two or more bottles containing reagents of the same type and lot information based on the manufacturing side management information read in the reading step;
If it is determined in the determination step that there are two or more bottles containing reagents of the same type and lot information, the information storage medium of two or more bottles containing reagents of the same type and lot information is stored. A writing step for writing bottle information, each of which can be identified,
A management step of managing the reagent in each bottle using the manufacturing side management information and / or the apparatus side management information in the information storage medium;
The management method characterized by including.   The management step manages the reagent in two or more bottles containing the reagent of the same type and lot information using the manufacturing side management information and the bottle information, and the reagents in other bottles. The management method according to claim 6, wherein management is performed using the manufacturing side management information.

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