JP2008285461A - Biomedical adhesive gel sheet and sheet-like cosmetic containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a self-adhesive gel sheet for living organisms that does not require a pretreatment such as immersion in a toilet lotion and exhibits an excellent moisture-retaining property, and a cosmetic obtained using the same. <P>SOLUTION: The self-adhesive gel sheet for living organisms comprises a hydrogel containing a gellant and a polyhydric alcohol compound and having a melting point of 37°C or lower. Preferably, the gellant is, for example, gelatin or a derivative thereof. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a bioadhesive gel sheet used in the fields of pharmaceuticals, quasi-drugs, cosmetics, hygiene materials, sundries, and the like, and a sheet-like cosmetic containing the same.

  Bioadhesive gel sheets are used for packs and patches for the treatment of beauty, facial and skin, carriers for active ingredients such as percutaneous absorption components and anti-inflammatory analgesic components, wound protection and drug immobilization, etc. It is used for adhesive tapes for living bodies, wound dressings and the like. These gel sheets increase the physiological function of the skin by sticking to the skin and increasing the skin temperature and water content (water retention), and this increased skin temperature and moisture is the activity in the sheet. Migration can be enhanced by penetration of the ingredients into the skin.

As for the gel sheet having such an action, a gel sheet containing polysaccharides such as collagen, chitin, chitosan, alginic acid and cellulose is known (for example, Patent Document 1). As gel sheets, there are known a type that does not dissolve at the time of use (removes after use) and a type that dissolves the sheet by impregnating lotion or the like at the time of use (for example, Patent Document 2).
Dissolving gel sheets have the advantage that reliable contact with the entire skin is possible compared to non-dissolving gel sheets. However, poor dissolution may occur depending on the composition of the skin lotion and the impregnation time, and the skin lotion is impregnated. The handling was troublesome.

In addition, there is a type of pack sheet in which an active ingredient is efficiently dissolved by laminating a water-containing gel sheet on a soluble film before use (for example, Patent Document 3). However, in this pack sheet, it is necessary to superimpose immediately before use, and a soluble dry film is brought into contact with the epidermis, so that the effect of imparting water retention may be insufficient.
Japanese Patent Laid-Open No. 3-81213 JP 2005-263785 A JP 2006-56804 A

  An object of the present invention made in order to solve the above-mentioned problems is to provide a living body pressure-sensitive adhesive gel sheet and a sheet-like cosmetic material that require no pretreatment and have a good moisturizing effect.

The bioadhesive gel sheet of the present invention comprises a hydrogel containing a gelling agent and a polyhydric alcohol compound and having a melting point of 37 ° C. or lower.
The gelling agent may be gelatin or a derivative thereof. In this case, it is preferable that the gelatin or the derivative thereof has a jelly strength of 280 g or less according to JIS K 6503.
In the above-mentioned bioadhesive gel sheet of the present invention, the hydrogel may further contain an excipient.
In this case, the excipient is preferably inorganic or organic fine particles.
Moreover, the said adhesive gel sheet for biological bodies of this invention may further have an insoluble support body layer.
The sheet-like cosmetic of the present invention includes the above-mentioned living body pressure-sensitive adhesive gel sheet.

  In the present invention, the “adhesive gel sheet for living body” refers to a pack or patch used for beauty, facial treatment, skin treatment, etc., a carrier for an active ingredient such as a percutaneous absorption component or an anti-inflammatory analgesic component, wound protection or drug fixation. A pressure-sensitive adhesive sheet that is applied directly to the skin for the purpose of holding active ingredients and moisture and penetrating into the skin. Say. This bioadhesive gel sheet is useful as a cosmetic material such as a pack for attaching moisture and active ingredients to the skin by applying it to the skin.

  ADVANTAGE OF THE INVENTION According to this invention, while pre-processing is unnecessary, the biological adhesive gel sheet and sheet-like cosmetics which have a favorable moisturizing effect can be provided.

The bioadhesive gel sheet of the present invention comprises a hydrogel containing a gelling agent and a polyhydric alcohol compound and having a melting point of 37 ° C. or lower.
The living body pressure-sensitive adhesive gel sheet of the present invention has a hydrogel having a melting point of 37 ° C. or lower, that is, lower than the body temperature, so that it is easily dissolved by sticking to the epidermis at the time of use. Can be granted. Therefore, according to the present invention, it is possible to obtain a biomedical pressure-sensitive adhesive gel sheet that does not require pretreatment and has a good moisturizing effect. It is useful as a sheet-like cosmetic for penetrating from the skin.
Hereinafter, the present invention will be described in detail.

[Hydrogel]
The hydrogel according to the present invention includes a gelling agent and a polyhydric alcohol compound, and has a melting point of 37 ° C. or lower.
Such a hydrogel is a thermosensitive gel that dissolves at around so-called body temperature, more preferably a hydrogel having a melting point at 20 ° C. to 37 ° C., and a hydrogel having a melting point at 23 ° C. to 35 ° C. More preferably it is. By using a thermosensitive gel, the influence of the external environment such as humidity and individual differences among subjects is reduced, and a certain effect is easily obtained. Here, the melting point of the hydrogel can be measured by a known method. For example, it can be measured by using the methods described in JP-A-6-279749 and JP-A-11-57455. Specifically, it may be measured using any one of a droplet dropping method, an inversion method, a CarriMed Rheometer method, and a viscosity method. In the present invention, it is preferably measured by the Rheometer method described in the publication.

<Gelling agent>
Examples of the gelling agent in the present invention include gelatin or a derivative thereof, a hydrophilic polymer, and the like. These may be used alone or in combination of two or more. Among these gelling agents, it is preferable to include at least gelatin or a derivative thereof that can easily adjust the melting point, have high compatibility with a living body, and can obtain a viscoelastic gel with good handleability. Moreover, as long as the solubility at the time of sticking is not impaired, it is preferable to combine gelatin or a derivative thereof with a hydrophilic polymer from the viewpoint of improving moisture retention.

Gelatin is a collagen hydrolyzed protein with no particular limitation on its production method, and is generally treated with acid treatment method or alkali treatment method using cow bone, cow skin, pig skin, and fish phosphorus as raw materials. However, it may be obtained by an enzymatic method. In the present invention, the weight average molecular weight of the gelatin measured by gel permeation chromatography (GPC) is preferably 50,000 to 300,000, particularly preferably 50,000 to 100,000. If the weight average molecular weight of gelatin is about 50,000 or more, shape retention can be made high. On the other hand, setting it to 300,000 or less is preferable because the solubility at the time of pasting is not impaired.
Examples of gelatin derivatives include known derivatives such as acid anhydride adducts of gelatin (eg, phthalated gelatin, succinated gelatin, trimellitated gelatin, etc.), and lactone adducts (glucono-δ-lactone). Addition gelatin, etc.), acylated gelatin (acetylated gelatin, etc.), esterified gelatin (methyl esterified gelatin, etc.), and the like. Of these, acid anhydride adducts are preferred from the viewpoints of meltability and handleability. Regarding the molecular weights of these gelatin derivatives, the matters described for gelatin can be applied as they are.

  The proportion of gelatin or a derivative thereof in the hydrogel can be 0.5% by mass to 20% by mass, preferably 1% by mass to 10% by mass, from the viewpoints of meltability and handleability. By making the content 0.5% by mass or more, it is possible to obtain a gel having a high water content and good handleability. On the other hand, by making the content 20% by mass or less, it is possible to improve the melting property.

  As a method for adjusting the melting point of the hydrogel to 37 ° C. or lower, it is possible to select a gelatin or derivative thereof having a jelly strength of 100 to 280 g based on JIS K6503. By selecting gelatin having a jelly strength in this range, the melting point of the gel can be easily designed to be 37 ° C. or lower. Moreover, it is more preferable to select a jelly strength of 150 to 200 g from the viewpoint of meltability.

Other methods for adjusting gelatin to the desired melting point include inorganic salts (eg sodium chloride, sodium nitrate, potassium chloride, etc.), organic acids or salts thereof (acetic acid, sorbic acid, stearic acid, palmitic acid, oleic acid, linoleic acid) Acid, linolenic acid, benzoic acid, cholic acid, etc.), organic amine compounds (triethylamine, trihexylamine, octylamine, etc.), alcohol compounds (ethanol, n-propanol, i-propanol, n-butanol, n-hexanol, n) -Octanol, cetyl alcohol, etc.) may be combined with gelatin to prepare a hydrogel. Among these, it is preferable to use in combination with an inorganic salt or an organic acid or a salt thereof from the viewpoints of meltability and handleability.
These inorganic salts, organic acids or salts thereof, organic salts, and alcohol compounds are generally 1 to 100% by mass with respect to gelatin or a derivative thereof, and preferably 5 to 50% by mass from the viewpoints of meltability and handleability. Added in an amount. By adding 1% by mass or more of these inorganic salts, organic acids or salts thereof, organic salts, and alcohol compounds with respect to gelatin or a derivative thereof, association between gelatin molecules can be suppressed and the melting point can be lowered. Moreover, the handleability as a hydrogel can be provided by setting it as 100 mass% or less.

  As the hydrophilic polymer used in the present invention, a synthetic polymer having a hydrophilic functional group (for example, hydroxyl group, carboxyl group, sulfo group, phospho group, carbamoyl group, amino group, ammonio group, ethyleneoxy group, etc.) Any natural polymer can be used. These may be used alone or in admixture of two or more.

  Suitable synthetic polymers having a hydrophilic group for the present invention include, for example, vinyl alcohol (co) polymer, 2-hydroxyethyl acrylate (co) polymer, acrylic acid (co) polymer, methacrylic acid (copolymer). ) Polymer, maleic acid (co) polymer, itaconic acid (co) polymer, p-vinylbenzoic acid (co) polymer, 2-acrylamido-2-methyl-1-propanesulfonic acid (co) polymer, Styrene sulfonic acid (co) polymer, acrylamide (co) polymer, acryloylmorpholine (co) polymer, N-vinylpyrrolidone (co) polymer, vinylamine (co) polymer, N, N-dimethyldiallylammonium chloride ( Co) polymer, 2-methacryloyloxyethylammonium chloride (co) polymer, polyethylene glycol methacrylate (co) polymer, poly Chiren'imin, and the like.

  Natural polymers having hydrophilic groups include neutral polysaccharides (eg, cellulose, amylose, amylopectin, dextran, pullulan, inulin, galactan, mannan, xylan, arabinan, glucomannan, galactomannan, hydroxyethylcellulose, methylcellulose, etc.) , Anionic polysaccharides (pectinic acid, alginic acid, agarose, agar, carrageenan, fucoidan, hyaluronic acid, chondroitin sulfate, heparin, gellan gum, native gellan gum, xanthan gum, carboxymethylcellulose, etc.), cationic polysaccharide (chitin, chitosan, cationization) Cellulose, etc.) and proteins (casein, elastin, etc.).

  These hydrophilic polymers may have a proportion of 0.1% to 5% by mass, preferably 0.2% to 3.% by mass, in the hydrogel from the viewpoints of meltability and handleability. . By making the content 0.1% by mass or more, the handling property of the gel can be improved. On the other hand, by making the content 5% by mass or less, the meltability can be improved and the viscosity of the melt can be reduced. .

<Polyhydric alcohol>
The hydrogel in the present invention contains at least a polyhydric alcohol compound from the viewpoints of melting point adjustment, moisture retention and handling properties. When the polyhydric alcohol is used as a pressure-sensitive adhesive gel sheet for a living body, it can improve the tackiness on the surface of the hydrogel and can act on the formation of crosslinking points in the hydrogel to lower the melting point.
Examples of polyhydric alcohols include glycerins (glycerin, diglycerin, etc.), glycols (eg, diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, 1,2-propanediol, 1,3-propanediol, dipropylene. Glycol, 1,2-butanediol, 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, etc., sugars (glucose, fructose, mannose, galactose, xylose) , Arabinose, glucosamine, N-acetylglucosamine, sucrose, lactose, maltose, isomaltose, trehalose, cellobiose, cordobiose, sophorose, maltotriose, raffinose, staki Over scan, etc.), sugar alcohols (glycerol, tray roll, erythritol, arabinitol, xylitol, ribitol, mannitol, sorbitol, galactitol, inositol, etc.). The said polyhydric alcohol can be used individually or in mixture of 2 or more types.

  Among these, as the polyhydric alcohol compound in the bioadhesive gel sheet of the present invention, a compound having a 1,2- or 1,3-diol structure is preferable, and glycerin, 1,2-propanediol, 1,2-butane is preferable. Alcohols such as diol, 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol are more preferable, and glycerin, 1,2-propanediol, 1,3-butanediol, 1,2- Hexanediol is particularly preferred.

  The proportion of the polyhydric alcohol in the hydrogel in the present invention is preferably 50% by mass or less, and particularly preferably 1 to 20% by mass. By setting the ratio of the polyhydric alcohol in the hydrogel to 50% by mass or less, good gel strength can be maintained, and the solubility at the time of sticking does not decrease, which is preferable.

<Excipient>
In the hydrogel of the present invention, it is preferable to add an excipient for further improving the shape stability. Examples of the excipient include organic or inorganic fine particles, hydrophilic or hydrophobic polymers and the like, and organic or inorganic fine particles are preferable from the viewpoint of shape stability. As the organic fine particles, known polystyrene particles, polymethacrylate particles, and microcrystalline cellulose are preferable. As the inorganic fine particles, silica, alumina, calcium carbonate, kaolin, clay mineral, and the like are preferable. Of these, silica or clay minerals are preferable, and gas phase method silica having an average particle diameter of 200 nm or less and synthetic smectite are particularly preferable.
The proportion of the excipient in the hydrogel in the present invention is preferably 10% by mass or less, particularly preferably 1 to 5% by mass, from the viewpoint of shape stability.

<Additives>
In the hydrogel in the present invention, various additives (active ingredients) can be further blended according to the purpose of use of the bioadhesive gel sheet. Such additives include, for example, medicinal ingredients for the purpose of beauty, facial treatment and skin treatment, as well as moisturizers, thickeners, fragrances, colorants, stabilizers, antioxidants, ultraviolet absorbers, and tackifiers. , PH adjusters, chelating agents, surfactants, preservatives, antibacterial agents and the like.

Examples of the humectant include amino acids, α-hydroxy acid salts (for example, sodium lactate, potassium lactate, potassium gluconate, etc.), urea, sodium pyrrolidonecarboxylate, betaine, whey and the like. These can be used alone or in admixture of two or more.
It is preferable that the compounding quantity in the hydrogel of a moisturizer is 0.1-10 mass%, and it is more preferable that it is 0.5-5 mass%.

  The medicinal ingredients are not particularly limited as long as they are conventionally used in pharmaceuticals, quasi drugs, cosmetics, hygiene materials, miscellaneous goods, and the like. For example, Ashitaba extract, Avocado extract, Achacha extract, Altea Extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, ages extract, echinacea leaf extract, sorghum extract, buckwheat extract, laurel extract, barley extract, hypericum extract, oleander Extract, Dutch mustard extract, orange extract, seawater dried product, seaweed extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, chamomile extract, carrot extract, kawara mugi extract, licorice extract, calcade extract, cypress , Kiwi extract, Kina extract, Cucumber extract, Guanosine, Gardenia extract, Kumazasa extract, Clara extract, Walnut extract, Grapefruit extract, Clematis extract, Chlorella extract, Mulberry extract, Gentianana extract, Tea extract, Yeast extract, Burdock extract, Rice bran extract , Rice germ oil, Comfrey extract, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Salvia extract, Soybean extract, Sasa extract, Hawthorn extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Citrus extract,

Peonies extract, ginger root extract, birch extract, horsetail extract, horse chestnut extract, hawthorn extract, horse elder extract, yarrow extract, mint extract, sage extract, mallow extract, sensu extract, senbu extract, soybean extract, tiso extract, Thyme extract, tea extract, clove extract, chigaya extract, chimpi extract, toki extract, toki-senka extract, tonin extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, Parsley extract, honey, hamamelis extract, parietaria extract, toad extract, bisabolol, loquat extract, dandelion extract, Mushroom extract, Bukuryu extract, Butcher bloom extract, Grape extract, Propolis, Loofah extract, Safflower extract, Peppermint extract, Bodaiju extract, Button extract, Hops extract, Pine extract, Maronier extract, Citrus extract, Mulberry extract, Melissa extract, Peach extract, Cornflower extract , Eucalyptus extract, Yukinoshita extract, Yuzu extract, Yokuinin extract, Artemisia extract, Lavender extract, Apple extract, Lettuce extract, Lemon extract, Lotus root extract, Rose extract, Rosemary extract, Roman chamomile extract, Royal jelly extract, etc., Plant-derived ingredients, seaweed Mention may be made of natural components such as derived components.

  Oily components such as sphingolipids, ceramides, cholesterol, cholesterol derivatives, phospholipids; anti-inflammatory agents such as ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhizic acid, lysozyme chloride, guaiazulene, hydrocortisone; vitamins A, B2, B6 , C, D, E, vitamins such as calcium pantothenate, biotin, nicotinamide, vitamin C ester; active ingredients such as allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid; tocophenol, β-carotene , Astaxanthin, canthaxanthin, fucoxanthin, β-cryptoxanthin, CoQ10, flavonoids, tannins, lignans, saponins, etc .; cell activators such as α-hydroxy acids, β-hydroxy acids; - oryzanol, blood circulation promoters, such as vitamin E derivatives; retinol, wound healing agents such as retinol derivatives; arbutin, kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, such as glutathione whitening agents;

Cephalanthin, licorice extract, red pepper tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride, dl-α-tocopherol, dl-α-tocopherol acetate, nicotinic acid, nicotinic acid derivatives, calcium pantothenate, D-pantothenyl alcohol, acetyl Pantothenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinyl esteradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, takanal, camphor, salicylic acid, nonyl acid vanillylamide, nonanoic acid vanillylamide, piroctone olamine, pentadecane Glyceryl acid, 1-menthol, mononitroguaiacol, resorcin, γ-aminobutyric acid, benzethoni chloride, mexihydrochloride Chin, auxin, female hormones, cantharis tincture, cyclosporine, hydrocortisone, monostearate polyoxyethylene sorbitan, and the like peppermint oil.
In addition, it is possible to add medicinal components such as analgesics, tranquilizers, antihypertensives, antibiotics, antihistamines, antibacterial substances, etc., as long as they can be administered into the living body by transdermal absorption. .

  The compounding amount of these active ingredients and medicinal ingredients cannot be defined unconditionally because the effective amount varies depending on the material, but generally it is preferably 0.001 to 10% by mass with respect to the total amount of hydrogel, 0.05 More preferably, it is -5 mass%.

  The proportion of water (liquid component) in the hydrogel according to the present invention is preferably 1 to 99% by mass, more preferably 5 to 95% by mass, and more preferably 10 to 90% by mass. preferable. In the range of 1 to 99% by mass of the liquid component contained in the hydrogel, various additives such as medicinal components blended in the gel can be easily dissolved and dispersed, and a practically sufficient gel layer Strength, and additives such as solvents and medicinal ingredients blended in the gel layer can be kept stable.

[Support layer]
In the bioadhesive gel sheet of the present invention, it is preferable that the hydrogel further has a water-insoluble support layer in order to improve shape stability and handleability. When using a support layer, it is preferable to peel and use only the support layer after pasting.
As such a support layer, a known support substrate in the form of a sheet such as a nonwoven fabric, a woven fabric, or a plastic film, or a crosslinked gel (gelatin / glutaraldehyde crosslinked gel, polyacrylic acid / polyvalent metal ion crosslinked gel, etc.) It is preferable to use a physical gel (such as agarose gel or κ-carrageenan gel) or a water-insoluble film (such as chitosan film, cellophane or κ-carrageenan cast film) formed from a hydrophilic polymer. Among these, in the pressure-sensitive adhesive gel sheet of the present invention, it is preferable to use a transparent film having a thickness of 100 μm or less, particularly a water-insoluble film (chitosan film, cellophane, κ-carrageenan cast film, etc.) formed from a hydrophilic polymer. Etc.) are preferred.

[Thickness of bioadhesive gel sheet]
The living body pressure-sensitive adhesive gel sheet of the present invention may be composed only of a hydrogel layer formed by forming a hydrogel into a layer. In this case, the thickness of the hydrogel layer is generally preferably from 0.4 to 3 mm, more preferably from 0.5 to 2 mm, from the viewpoint of shape retention and handleability.
In the case of a biomedical adhesive gel sheet having a hydrogel layer and a support layer, the thickness of the support layer is preferably 100 μm or less from the viewpoint of shape stability and handleability of the bioadhesive gel sheet. 5 to 80 μm is more preferable. In the case of such a multilayer structure, the thickness of the hydrogel may be the same as the thickness of the hydrogel layer described above, and the thickness of the bioadhesive gel sheet as a whole is suitably in the range of 0.4 to 3 mm. You may adjust.

The shape of the bioadhesive gel sheet of the present invention is not particularly limited, but it may be provided in a tape-like shape wound in a roll shape, or may be an individual sheet that is independent of each other. In the case of individual sheets, the shape is arbitrary, and examples thereof include an ellipse, a circle, a heart shape, a semicircle, a semielliptical shape, a square, a rectangle, a trapezoid, a triangle, or a combination of these, etc. You may design suitably the shape which can be affixed most appropriately with the shape along an application site | part, and a use site | part. In addition, the convex and concave portions are provided for the purpose of alignment, etc. at the center and the peripheral portion of the bioadhesive gel sheet, or the cut and cut-out portions are provided according to the shape of the part to be used to improve the handleability of the bioadhesive gel sheet. It may be improved.
In order to protect the surface of the pressure-sensitive adhesive gel sheet for use up to the time of use, the hydrogel may be coated with a protective sheet, and in order to prevent moisture and active ingredients from decreasing over time, It may be sealed one by one in a packaging material made of a breathable sheet.

The application site of the bioadhesive gel sheet of the present invention includes a face (lips, cheeks, eyes, upper and lower parts of eyes, nose, forehead, entire face), arms, legs, chest, abdomen, back, The neck etc. are mentioned.
In the living body pressure-sensitive adhesive gel sheet, not only the above-described shape but also the area, thickness, pressure-sensitive adhesive properties of the outermost surface of the hydrogel, and the like may be appropriately adjusted according to the application site.
For example, when forming an adhesive sheet where the application site is the entire face, the part corresponding to the position of the eyes and mouth is cut out, and the part corresponding to the position of the nose is cut, and the pasting area is large. Therefore, it is preferable to make adjustments such as increasing the adhesive strength of the adhesive layer or reducing the thickness. Further, the face shape may be divided into two parts, and divided into an upper part applied around the forehead, eyes and nose, and a lower part applied around the mouth to the chin part.
The living body pressure-sensitive adhesive gel sheet of the present invention is particularly useful as a sheet-like cosmetic material that is applied to the face in such a manner to moisturize the skin and give medicinal ingredients.

  Since the bioadhesive gel sheet of the present invention has the above-described configuration, the pretreatment is not required and the handleability is good, and a high moisture retention effect is achieved by adhering a hydrogel layer that stably holds a large amount of liquid components to the living body surface. Is useful as a carrier for active ingredients. For this reason, the adhesive gel sheet for living bodies of the present invention can be applied in a wide range.

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited thereto. Unless otherwise specified, “part” and “%” represent “part by mass” and “% by mass”, respectively.
[Example 1]
Phthalate gelatin 0.5 part (jelly strength 150 g, molecular weight 300,000 or less: Nitta Gelatin Co., Ltd.) and 1,3-butanediol 2.0 part are dissolved in water 7.1 part. To this solution, 0.4 part of synthetic smectite (Lucentite SWN: manufactured by Corp Chemical Co., Ltd.) is added and stirred at 40 ° C. and 10,000 rpm for 10 minutes. The resulting solution was cast into a 65 mm × 95 mm polystyrene case and cooled at 4 ° C. for 16 hours to obtain a hydrogel of this example. The melting point of the hydrogel of Example 1 was measured by the Rheometer method. That is, after heating this hydrogel to 60 ° C, it is introduced into a rotational viscometer (Tokyo Keiki E-type viscometer VISCONIC EHD), cooled to 10 ° C and completely gelled, and then heated again to raise the temperature. The viscosity was measured at 2 ° C. intervals at 100 rpm. As a result, a rapid decrease in viscosity was observed at 25 ° C. Therefore, the melting point of the hydrogel of this example was 25 ° C.
[Example 2]
A hydrogel of this example was obtained in the same manner as in Example 1 except that 1,3-butanediol of Example 1 was changed to glycerin. The melting point of the hydrogel of Example 2 was 32 ° C. as measured by the Rheometer method as in Example 1.

Example 3
A hydrogel of this example was obtained in the same manner as in Example 1 except that the phthalated gelatin of Example 1 was changed to succinated gelatin (jelly strength: 180 g, molecular weight: 300,000 or less; manufactured by Nitta Gelatin). The melting point of the hydrogel of Example 3 was 26 ° C. as measured by the Rheometer method as in Example 1.
Example 4
0.5 part of phthalated gelatin of Example 1 was combined with 0.4 part of acid-treated gelatin derived from pig skin (jelly strength: 270 g, molecular weight of 300,000 or less; manufactured by Nitta Gelatin) and 0.1 part of linolenic acid. Except for the change, the hydrogel of this example was obtained in the same manner as in Example 1. The melting point of the hydrogel of Example 4 was 27 ° C. as measured by the Rheometer method as in Example 1.

Example 5
0.5 g of chitosan (Daichitosan 100D: manufactured by Dainichi Seika Kogyo Co., Ltd.) was gradually added to 49.5 g of a 1% by mass acetic acid aqueous solution and stirred at 40 ° C. for 3 hours to obtain a chitosan acetate aqueous solution. 18 g of this solution is placed in a 95 × 60 mm styrene square case and dried at 80 ° C. for 2 hours. The dried chitosan gel film was immersed in a 10% by mass sodium hydroxide methanol solution for 60 minutes, washed for 10 minutes under running water, and then air-dried to obtain a chitosan film having a thickness of 30 μm. Using this chitosan film as a support, the same hydrogel as in Example 1 is spread on the surface using a doctor blade so that the coating thickness is 1 mm. This was allowed to stand at room temperature for 2 hours to complete the gelation to obtain the hydrogel of this example. The melting point of the hydrogel layer of Example 5 was 25 ° C. as measured by the Rheometer method as in Example 1.

[Comparative Example 1]
0.4 parts of acid-processed gelatin derived from pig skin (jelly strength: 270 g, molecular weight of 300,000 or less: Nitta Gelatin), 0.1 part of glutaraldehyde, 2.0 parts of 1,3-butanediol were added to 7.5 parts of water. Dissolve in part. The resulting solution was cast into a 65 mm × 95 mm polystyrene case and heated at 40 ° C. for 16 hours to complete the gelation, and a comparative hydrogel was obtained. The melting point of the hydrogel of Comparative Example 1 was 45 ° C. as measured by the Rheometer method as in Example 1.
[Comparative Example 2]
0.09 parts of sodium alginate (degree of polymerization 100 to 130) and 0.05 parts of sodium alginate (degree of polymerization 260) are dissolved in 9.86 parts of water. This solution was dispensed in depth into a 65 mm × 95 mm size container and then freeze-dried by a conventional method to obtain a comparative dissolution sheet. The comparative sheet was used after impregnating the serum for 1 minute immediately before the evaluation. The melting point of the hydrogel of Comparative Example 2 was 40 ° C. as measured by the Rheometer method as in Example 1.

[Comparative Example 3]
0.15 parts of agar, 0.08 parts of xanthan gum and 2.0 parts of 1,3-butanediol are added to 7.77 parts of water and dissolved by heating at 80 ° C. The obtained solution was cast into a 65 mm × 95 mm polystyrene case and allowed to stand at 25 ° C. for 16 hours to complete gelation. This hydrogel and a hydroxypropyl cellulose film having a thickness of 30 μm were pasted together immediately before the evaluation to obtain a partially dissolved sheet for comparison. The melting point of the hydrogel of Comparative Example 3 was 78 ° C. as measured by the Rheometer method as in Example 1.
[Comparative Example 4]
A comparative hydrogel was obtained in the same manner as in Example 1 except that the phthalated gelatin of Example 1 was changed to acid-treated gelatin derived from pig skin and 1,3-butanediol was changed to water. The melting point of the hydrogel of Comparative Example 4 was 38 ° C. as measured by the Rheometer method as in Example 1. Acid-treated gelatin phthalated gelatin derived from pig skin

(Evaluation of bioadhesive gel sheet)
About the adhesive gel sheet obtained by the said Example and comparative example, it evaluated by the following methods and references | standards, and the result was shown in following Table 1.
The adhesive gel sheet was actually used on a monitor and attached to the face, and the operability at that time was evaluated according to the following criteria. In addition, the result of the sensory evaluation was shown by the average value of 10 monitors.
(1) Operability A is attached when it is attached to the face without sticking to the finger and can be attached easily, B is attached when attaching to the finger and it takes time to attach, and it is easily broken and attached. The case where it was difficult was evaluated as C.
(2) Feeling of adhesion A when the adhesive gel sheet for living affixed to the face by the operation of (1) adheres along the surface of the face, A when the partial lift occurs, and wrinkles at each part. The case where a large number of floats occurred was evaluated as C.
(3) Solubility A is the case where the bioadhesive gel sheet adhered to the face for 15 minutes by the operation of (2) is uniformly dissolved, B is the case where it is dissolved but dripping, and the undissolved semi-solid is The case of remaining on the face was evaluated as C.
(4) Moisturizing feeling After pasting, the case where a satisfactory moisturizing feeling was obtained was evaluated as A, the case with a sticky feeling was evaluated as B, and the case where no moisturizing feeling was obtained was evaluated as C.
Each evaluation result is shown in Table 1.

From the results of Table 1, the living body pressure-sensitive adhesive gel sheets according to Examples 1 to 5 of the present invention do not require pretreatment such as impregnation into skin lotion, and are easy to handle, and the hydrogel does not adhere when applied. A good feeling of adhesion and moisturizing can be obtained by dissolution.
Therefore, according to the present invention, it is possible to provide a living body pressure-sensitive adhesive gel sheet that does not require pretreatment or the like and has good moisture retention.

Claims (7)

  A bioadhesive gel sheet comprising a gelling agent and a polyhydric alcohol compound and having a hydrogel having a melting point of 37 ° C or lower.   The bioadhesive gel sheet according to claim 1, wherein the gelling agent is gelatin or a derivative thereof.   The bioadhesive gel sheet according to claim 2, wherein the gelatin or a derivative thereof has a jelly strength of 280 g or less in accordance with JIS K 6503.   The bioadhesive gel sheet according to any one of claims 1 to 3, wherein the hydrogel further comprises an excipient.   The bioadhesive gel sheet according to claim 4, wherein the excipient is inorganic or organic fine particles.   The bioadhesive gel sheet according to any one of claims 1 to 5, further comprising an insoluble support layer.   A sheet-form cosmetic comprising the bioadhesive gel sheet according to any one of claims 1 to 6.