JP2008139132A - Physiological examination device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To easily perform the discarding of a liquid or the washing or the like of an examination container and to enhance an examination precision in a physiological examination device constituted so as to put the liquid separated from the human body such as urine, blood, etc. in the examination container to directly examine the same. <P>SOLUTION: In the physiological examination device 100 equipped with the examination container 5 for housing the liquid such as urine, blood, etc. discharged from the human body, a light emitter 1 for emitting light, a spectroscope 3 for spectrally diffracting the light emitted from the light emitter 1 and a photodetector 6 (61 and 62) for detecting the light transmitted through the liquid in the light spectrally diffracted by the spectroscope 3, the examination container 5 is irradiated with the light spectrally diffracted by the spectroscope 3 from the outside and the photodetector 6 is provided outside opposed to the examination container 5 to detect the transmitted light from the examination container 5. The liquid non-housing region 52 and liquid housing region 53 in the examination container 5 is irradiated with the light spectrally diffracted by the spectroscope 3 and the respective transmitted lights are detected by the photodetector 6. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a biopsy apparatus that can determine the human health condition by irradiating light to urine or blood discharged from a human body.

  In recent years, various methods for optically examining human urine and blood have been proposed. For example, the methods described in JP-A-63-94158 and JP-A-2-27262, There are known inspection methods described in Japanese Patent No. 248622, Japanese Patent Application Laid-Open No. 11-271222, Japanese Patent Application Laid-Open No. 2005-148018, and the like.

  Each of these methods will be explained. First, the methods described in JP-A-63-94158 and JP-A-2-27262 are designed to perform inspection using test paper coated with a reagent. Then, urine is soaked in a test paper and the color reaction is optically measured so that the components of urine can be examined.

The methods described in JP-A-11-248622, JP-A-11-271222, and JP-A-2005-148018 are provided with a test container for storing urine. In this state, the urine is irradiated from the urine with the light dispersed therein, and the urine is examined from the change in the wavelength of the light. This method will be described with reference to FIG. 4. 91 is a light source, 92 is a spectroscope, 93 is an optical fiber that outputs light from the spectroscope, and 94 is a glass test container for storing urine. Inside the cuvette 94, there are provided a distal end portion 93a of an optical fiber 93 and a light receiver 95, which irradiates light from the distal end portion 93a of the optical fiber 93 soaked in urine. By receiving light with a light receiver 95 provided in the urine, a specific component in urine such as sugar and protein can be measured.
JP-A-63-94158 JP-A-2-27262 Japanese Patent Laid-Open No. 11-248622 JP 11-271222 A JP 2005-148018 A

  By the way, among the above prior arts, the method described in the former JP-A-63-94158 and JP-A-2-27262 requires the use of a test paper coated with a reagent. Paper is required and the cost is high. In addition, it has been pointed out that the method of inspecting by the indirect method using the reaction with the test paper tends to cause an error in the inspection result.

  On the other hand, the methods described in the latter JP-A-11-248622, JP-A-11-271222, JP-A-2005-148018, etc. do not require the use of reagents, test papers, etc. The running cost can be reduced. However, in this method, since the tip of the optical fiber and the light receiver are mounted in the inspection container, the inspection container must be cleaned for each use. Further, when throwing away urine, there arises a problem that the optical fiber and the connection portion of the light receiver must be once removed from the test container.

  Therefore, the present invention has been made paying attention to the above problems, and in a biological examination apparatus in which a liquid separated from a human body such as urine or blood can be directly inspected by placing it in an examination container, the disposal of the liquid It is an object of the present invention to provide a living body inspection apparatus that can easily clean the inspection container and the like and can improve the inspection accuracy.

  That is, in order to solve the above-described problems, the present invention separates a test container for storing a liquid such as urine or blood discharged from a human body, a light emitter that emits light, and light emitted from the light emitter. In a living body inspection apparatus comprising a spectroscope and a light receiver that receives light that has passed through a liquid out of the light dispersed by the spectroscope, the light dispersed by the spectroscope is irradiated from the outside of the cuvette. The light receiver is provided on the outer side of the cuvette so as to receive the transmitted light from the cuvette.

  With this configuration, light irradiation and light reception are performed from the outside of the cuvette, eliminating the need to attach an optical fiber tip or light receiver to the cuvette, and simply removing the cuvette and cleaning the cuvette. Can do. In addition, urine can be easily discarded.

  In such an invention, the light dispersed by the spectroscope is irradiated to the liquid storage area and the liquid non-storage area in the cuvette, and each transmitted light is received by the light receiver.

  Normally, when light is irradiated from the outside of the cuvette, the properties of the transmitted light may change depending on the material of the cuvette and an incorrect test result may be output. By irradiating the storage area with light and receiving the transmitted light, it is possible to perform an accurate inspection in consideration of the error from the difference between the transmitted light in the liquid storage area and the liquid non-storage area.

  Furthermore, when irradiating light to the liquid storage region and the liquid non-storage region, the light is split so that a spectral line along the vertical direction appears, and the spectrum is horizontally aligned so as to include each spectral line that has been split. A plurality of extractions are performed, and each extracted spectrum is irradiated to the liquid storage area and the liquid non-storage area.

  If configured in this way, the same two spectra can be generated by one spectrometer, and if the two spectra are irradiated to the liquid storage area and the liquid non-storage area of the cuvette, an error will occur. This makes it possible to carry out a precise inspection with less. At this time, since only one spectroscope needs to be provided, the apparatus can be reduced in cost and size.

  According to the present invention, a test container that stores liquids such as urine and blood discharged from the human body, a light emitter that emits light, a spectroscope that splits light emitted from the light emitter, and the spectroscope And a light receiving device that receives light transmitted through the liquid among the light dispersed by the light, and irradiates the light separated by the spectroscope from the outside of the inspection container, and the light receiving device is irradiated to the inspection container. Since it is provided outside the opposite side of the tube to receive the transmitted light from the cuvette, it is necessary to irradiate and receive light from the outside of the cuvette, so there is no need to attach an optical fiber tip or light receiver to the cuvette The inspection container can be easily removed and the inspection container can be cleaned. In addition, urine can be easily discarded.

  Hereinafter, an embodiment of the present invention will be described with reference to the drawings. FIG. 1 is a configuration diagram illustrating the principle of the biological examination apparatus 100, and FIG. 2 is a diagram illustrating functions of the biological examination apparatus 100.

  First, the biopsy device 100 will be described in detail with reference to FIG. 1. The biopsy device 100 according to the present embodiment includes a test container 5 that stores urine discharged from humans, collected blood, and the like, and its test. A light emitter 1 that emits light from the outside of the container 5, a spectroscope 3 that separates light emitted from the light emitter 1, and a first light that separates light split by the spectroscope 3 into two slit lights. A second separator 4, a light receiver 6 that receives light irradiated on the cuvette 5 through the slit of the second separator 4, and a display device that outputs information received by the light receiver 6. 7.

  Among these, the light emitter 1 outputs light emitted from the light source as one elongated slit light. As the light source, for example, a halogen lamp having a uniform spectrum over all wavelength regions is used. The light output from the halogen lamp is applied to the first separator 2 provided in front of the halogen lamp, and is output as one slit light in the longitudinal direction by the slit 21 in the longitudinal direction provided in the central portion. The In this embodiment, a halogen lamp is used as a light source. However, the present invention is not limited to this, and a fluorescent lamp, a white light bulb, an LED, or the like can be used. It may output light having a wavelength suitable for inspection. For example, when examining urine, using an LED that outputs light in the near-infrared region of 700 nm to 1200 nm, where the absorbance of water is extremely low, the absorbance of urine components other than water can be emphasized and measured. In addition, when a light having a wavelength of 1200 nm to 2500 nm at which the absorbance of water greatly increases, the absorbance of urine components other than water can be measured by reducing the absorbance of water.

  The spectroscope 3 is constituted by a triangular prism, and splits the slit light output from the slit 21 of the first separator 2. Similarly, the split light is split into light having a spectral line along the longitudinal direction. In this embodiment, a triangular prism having a triangular bottom surface is used as the spectroscope 3, whereby red light, orange light, yellow light, green light, blue light, indigo light, violet light, etc. in the longitudinal direction. To obtain a spectral line.

  Reference numeral 4 denotes a second separator, which is attached in front of the spectrometer 3. The light split by the spectroscope 3 is applied to the two horizontal slits 41 and 42 provided in the second separator 4, and the upper slit light 41 a is output from the upper slit 41 and the lower slit 42. Outputs the lower slit light 42a. These upper slit light 41a and lower slit light 42a include spectral lines along the vertical direction of red, orange, yellow, green, blue, indigo, and purple, respectively. The upper slit light 41 a is irradiated above the center of the cuvette 5, and the lower slit light 42 a is irradiated below the center of the cuvette 5.

  The cuvette 5 is formed of transparent glass, plastic, or the like, and is configured so that it can be easily detached from the apparatus 100 main body. This cuvette 5 stores biological separations such as urine and blood, and is provided with a water injection line 51 serving as a reference for water injection at the center or above the center. After injecting urine or blood below the water injection line 51, the lower slit light 42a separated by the second separator 4 is irradiated to the lower side of the water injection line 51, that is, the liquid storage region 53. In addition, the upper slit light 41a separated by the second separator 4 is irradiated to the upper side of the water injection line 51, that is, the liquid non-storage area 52. In this irradiation, in order to prevent light reflection and refraction by the cuvette 5, the side of the cuvette 5 configured as a hollow rectangular parallelepiped is irradiated perpendicularly.

  The light receivers 6 are provided at two locations on the outside of the cuvette 5 and receive light transmitted through the liquid non-storage area 52 and the liquid storage area 53, respectively. The light receiver 6 is configured by a CCD, a photodiode, or the like, and receives transmitted light such as the cuvette 5 or urine out of the light dispersed by the spectroscope 3. The received light is enlarged and output to the display device 7 as it is as a spectrum image, or the received light image is analyzed by the analysis unit 8 and then output as the analysis result. The light receiver 6 may be one having sensitivity to a wavelength corresponding to the output peak from the light emitter 1.

  The display device 7 displays the reference data and the inspection data so that they can be compared and compared. For example, as shown in FIG. 3, the display device 7 displays the inspection result data on the upper side of the screen, and the reference on the lower side. Display data. Here, the reference data refers to data and images generated based on urine collected from a healthy person in advance, and includes the amount of shift (numerical value) of the spectrum of light emitted from the light source and the amount of shift. Spectral image. These reference data are stored in advance in the memory and displayed on the display device 7. On the other hand, the inspection result data indicates a spectral image based on light transmitted through the liquid non-storage region 52, a spectral image based on light transmitted through the liquid storage region 53, or a shift amount of spectral lines in these spectral images. Data. When this inspection data is displayed, for example, a spectral image based on light transmitted through the liquid non-storage region 52 and a spectral image based on light transmitted through the liquid storage region 53 are displayed as they are. A numerical value obtained by subtracting the shift amount of the spectral line of the light transmitted through the liquid non-storage region 52 from the shift amount of the spectral line of the light transmitted through the liquid 53 is displayed.

  Further, the display device 7 can optically analyze the received spectrum and display the analysis result as numerical data. When such a method is used, an analysis unit 8 is provided, and the transmitted light of the liquid non-storage region 52 and the liquid storage region 53 is output to the analysis unit 8 to detect the shift amount of each spectral line. In this detection, for example, the RGB (red, green, blue) value at each pixel is measured from the received image, and the reference value is stored from a position that almost matches the RGB value stored in advance for each pixel. Measure the deviation. Then, the component data in urine is read out from the deviation amount with respect to each RGB numerical value and displayed on the display device 7, or the deviation amount is directly displayed as a numerical value on the display device 7.

  When displaying the numerical value of the inspection result data on the display device 7, since it is expensive to provide the analysis unit 8 in the inspection device 100, for example, when the inspection device 100 has a communication function. May transmit the received image to the server computer via the Internet and perform analysis there. At present, mobile phones with camera functions are widely used, so that the transmitted light is received using a light receiver provided in the camera function of the mobile phone and the server computer is used using the communication function of the mobile phone. The inspection image may be transmitted to the analysis unit 8. Then, the analyzed result may be directly browsed on the website, or the test result may be received by e-mail later. However, since the mobile phone is often provided with only one camera lens, the light in the liquid non-storage area 52 and the light in the liquid storage area 53 are received as a single body, and the respective images are separated using software. To enable analysis processing.

  Next, processing using the thus configured biopsy apparatus 100 will be described.

  First, when a living body is inspected from discharge such as urine, the inspection container 5 is taken out from the living body inspection apparatus 100 and urine or the like is put into a water injection line 51 in the container. Then, the cuvette 5 is housed in the biological examination apparatus 100, and the illumination of the light emitter 1 is turned on. Then, light is output from the light emitter 1, and the first separator 2 is irradiated with the light. And light is irradiated to the slit 21 of the longitudinal direction provided in the 1st isolation | separation body 2, and the thin light of a longitudinal direction is output from there. The light in the longitudinal direction is output to the spectroscope 3, where it is similarly separated into light having a spectral line along the longitudinal direction. The separated light is further irradiated to the second separator 4 provided on the downstream side thereof, and is then irradiated to the upper slit 41 and the lower slit 42 provided above and below. At this time, each of the upper slit 41 and the lower slit 42 is irradiated with light including a plurality of spectral lines along the vertical direction, and horizontal slits including a plurality of spectral lines are output from the respective slits 41 and 42. Is done. Of the slit light 41a and 42a output from the upper slit 41 and the lower slit 42, the upper slit light 41a output from the upper slit 41 is irradiated from the outside to the liquid non-storage region 52 in the cuvette 5, The lower slit light 42a output from the lower slit 42 is applied to the liquid storage region 53 in the inspection container from the outside. The irradiated slit lights 41a and 42a pass through the cuvette 5 and urine, and then are received by the light receivers 61 and 62 provided outside the cuvette 5, respectively. At this time, the light transmitted through the liquid non-storage area 52 has a spectrum that varies depending on the material of the cuvette 5, and the light transmitted through the liquid storage area 53 varies depending on the material of the cuvette 5, urine, and the like. Spectrum.

  In the first embodiment, the light received by the light receivers 61 and 62 is displayed on the display device 7 as it is. When displaying this spectrum, the spectrum of the light transmitted through the liquid non-storage region 52 and the spectrum of the light transmitted through the liquid storage region 53 are set so that the shift amount of each spectral line can be recognized in one screen. Are displayed simultaneously. At this time, distribute the materials to the user to inform the user of the amount of each component based on the amount of deviation of the spectrum line, or display the amount of each component based on the amount of deviation on the screen. .

  In the second embodiment, the light received by the light receivers 61 and 62 is output to the analysis unit 8, where the amount of deviation with reference to the transmitted light of the liquid non-storage region 52 is detected, and Each component is analyzed by calculating the difference between the shift amount and the shift amount between the spectral lines in the reference data. Then, the analysis result is displayed and output on the display device 7.

  As described above, according to the above embodiment, the light separated by the spectroscope 3 is irradiated from the outside of the cuvette 5, and the light receivers 61 and 62 are provided outside the cuvette 5 to face the cuvette 5. Therefore, it is not necessary to attach a tip portion of an optical fiber or a light receiver in the inspection container, and the inspection container 5 can be easily removed and cleaned. Moreover, urine etc. put in the inspection container 5 can also be discarded easily.

  In addition, since the light separated by the spectroscope 3 is irradiated to the liquid non-storage area 52 and the liquid storage area 53 in the cuvette and the respective transmitted lights are received by the light receivers 61 and 62, the liquid non-storage area From the difference in transmitted light between the storage area 52 and the liquid storage area 53, an accurate inspection can be performed in consideration of the error.

  Furthermore, when irradiating light to the liquid non-storage region 52 and the liquid storage region 53, the spectral is performed so that the spectral lines along the vertical direction appear, and the spectral is horizontally applied so as to include the spectral lines that are split. Since at least two of the extracted spectra are extracted and the liquid non-storage region 52 and the liquid storage region 53 are irradiated with each of the extracted spectra, the same two spectra can be extracted by one spectroscope 3. If the two spectra are irradiated to the liquid non-storage area 52 and the liquid storage area 53 of the inspection container 5, an inspection with little error can be performed. At this time, since only one spectroscope 3 needs to be provided, the device 100 can be reduced in cost and size.

  In addition, this invention can be implemented in various aspects, without being limited to the said embodiment.

  For example, in the above embodiment, two light receivers are provided so as to receive the transmitted light of the liquid non-storage region 52 and the transmitted light of the liquid storage region 53, respectively, but this is received by a single light receiver. You may make it do.

  In the above embodiment, the display device 7 is configured to display the transmitted light spectrum of the liquid non-storage area 52 and the transmitted light spectrum of the liquid storage area 53. For example, the difference between the spectrum lines is taken. Only the shift amount may be displayed.

  Furthermore, in the said embodiment, although the light-emitting device 1, the spectroscope 3, the test container 5, the light receivers 61 and 62, the display apparatus 7, etc. are comprised, the biopsy apparatus 100 is comprised, These each function For example, the light emitting device 1 to the cuvette 5 may be integrated, and the light receivers 61 and 62 and the display device 7 may be used also as functions of other devices.

FIG. 1 is a principle diagram of a biological examination apparatus according to an embodiment of the present invention. Functional block diagram of a biopsy device in the same form The figure which shows the display state of the display in the same form The figure which shows the structure of the conventional inspection device

Explanation of symbols

DESCRIPTION OF SYMBOLS 100 ... Biopsy apparatus 1 ... Light emitter 2 ... 1st separated body 21 ... Slit 3 ... Spectroscope 4 ... 2nd separated body 41 ... Upper slit 42- ..Lower slit 41a ... Upper slit light 42a ... Lower slit light 5 ... Inspection container 51 ... Water injection line 52 ... Liquid non-storage area 53 ... Liquid storage area 6 (61, 62) ) ... Receiver 7 ... Display device 8 ... Analysis unit

Claims (3)

  A test container that stores liquids such as urine and blood discharged from the human body, a spectroscope that splits light emitted from the light emitter, and light that has passed through the liquid out of the light that has been split by the spectroscope. In a living body inspection apparatus comprising a light receiver, the light split by the spectroscope is irradiated from the outside of the inspection container, and the light receiver is provided on the outer side facing the inspection container to receive the transmitted light from the inspection container. A biopsy device characterized by that.   The biopsy apparatus according to claim 1, wherein the light dispersed by the spectroscope is irradiated to a liquid storage area and a liquid non-storage area in the test container, and each transmitted light is received by a light receiver.   Using the spectroscope, the spectrum is split so that the spectral lines along the vertical direction appear, and a plurality of spectra are extracted along the horizontal direction so as to include the spectral lines that have been split. The biopsy apparatus according to claim 2, wherein the liquid storage area and the liquid non-storage area are irradiated.

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