JP2008114037A - Blood pressure measuring device and blood pressure measuring device control method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a blood pressure measuring apparatus reducing a physical burden of a subject, capable of measuring a part except for a finger liable to move and measuring the blood pressure stably for a long period of time; and also to provide a control method for the blood pressure measuring apparatus. <P>SOLUTION: By this blood pressure measuring apparatus and the control method for this blood pressure measuring apparatus stably, a peripheral vascular resistance in a local part of the peripheral vessel of the subject distributed in parallel to each another is retained by pressurization and a blood pressure value is estimated from a change in the volume of the blood flow flowing in the peripheral vessel to be pressurized. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a blood pressure measurement device that measures blood pressure and a blood pressure measurement device control method.

  With the aging of society, dealing with adult lifestyle-related diseases has become a major social issue. It is recognized that long-term blood pressure data collection is very important, especially for diseases related to high blood pressure. From such a point of view, various biological information measuring devices including blood pressure have been developed (for example, see Non-Patent Document 1).

  Strictly speaking, the blood pressure value changes every heartbeat. In patients with advanced arteriosclerosis, there is a risk of death due to an increase in blood pressure for one beat. For example, in patients with advanced cerebrovascular arteriosclerosis, there is a possibility that cerebrovascular disorders may be caused by an instantaneous increase in blood pressure, leading to the development of cerebral infarction. Even if the normal blood pressure value is not so high, if the blood pressure value instantaneously increases frequently, it is considered that the normal blood pressure value is also affected. In other words, it is important to constantly monitor the blood pressure value to grasp the blood pressure fluctuation for each beat and detect these signs as soon as possible.

  Conventionally, methods for constantly monitoring blood pressure values have been realized by measurement methods such as a direct method and a volume compensation method. In the present specification, the names of the outer ears are based on Non-Patent Documents 2 and 3. The direct method is a method of measuring the blood pressure value from the height of the level of blood flowing into the catheter when the catheter is inserted into the blood vessel. The volume compensation method is a method of obtaining a continuous blood pressure value and a waveform by compressing the blood vessel with liquid or air from outside the blood vessel with the cuff and controlling the pressure inside the cuff so as to cancel the pulsation of the blood vessel. .

Kenichi Yamakoshi, Tatsuo Togawa, “Biosensor and Measuring Device”, MM Japan Society / ME textbook series A-1, pages 39-52 Sobotta Illustrated Human Anatomy Volume 1 (Translation by Michio Okamoto), p. 126, Medical School, issued October 1, 1996 The Atlas of Human Body, p. 20, Kodansha Co., Ltd., published on January 29, 2004, 35th edition

  However, the direct method described above is invasive because it is necessary to use a catheter, and a physical load is applied to the subject. In addition, since there is a physical load on the subject, it is not suitable for long-time continuous measurement. On the other hand, in the volume compensation method, since the measurement site is limited to the finger, it is sensitive to the movement of the body and easily mixed with noise. Further, it is necessary to close the blood flow by strongly pressing the measurement site, and the volume compensation method is not suitable for continuous measurement for a long time.

  Therefore, in the present invention, there is provided a blood pressure measurement device and a blood pressure measurement device control method capable of measuring a blood pressure value that can be measured with a finger other than an easy-to-move finger with less physical burden on the subject and that can stably monitor a blood pressure value for a long time. The purpose is to provide.

  In order to solve the above problems, in the present invention, the blood pressure value is obtained from the blood flow rate of blood flowing in the peripheral blood vessel while maintaining the peripheral vascular resistance of the peripheral blood vessel of the subject constant.

  First, the basic principle of the blood pressure measurement device and the blood pressure measurement device control method according to the present invention will be described.

  FIG. 1 shows the structure of a subcutaneous blood vessel in a living body. FIG. 2 shows a circuit configuration diagram in the case where a blood circulation system of a living body is simulated as an electric circuit. Note that FIG. It is the figure which extracted a part of skin structure.

  As shown in FIG. 1, the subcutaneous structure of a living body is formed in the order of epidermis 141, dermis 142, and subcutaneous tissue 143. In particular, focusing on the subcutaneous blood vessels of the living body, the subcutaneous structure of the living body has an arterial region 121 where an artery 131 having a relatively large blood vessel diameter exists, and an arteriole 132 whose blood vessel diameter is smaller than the blood vessel diameter of the blood vessel existing in the arterial region 121. Are formed in the order of the arteriole region 122 where the blood vessel exists, and the capillary region 123 where the blood vessel diameter is smaller than the blood vessel diameter of the blood vessel existing in the arteriole region 122. As described above, the blood vessel diameter decreases as the structure of the blood vessel changes from the artery 131 to the arteriole 132 and the capillary blood vessel 133, and the blood pressure value decreases. The drop in blood pressure from the artery 131 to the arteriole 132 is greatest, and when reaching the capillary 133, the blood pressure drops to about 20 mmHg. Thus, the arteriole 132 is considered to have a property like electric resistance in an electric circuit. In the present specification, arterioles may be referred to as “peripheral blood vessels”.

  In general, blood pressure can be simply expressed as the product of cardiac output and peripheral vascular resistance. The blood pumped out from the left ventricle (not shown) always flows into the right ventricle (not shown) through the aorta (not shown), the artery 131, the arteriole 132, and the capillary 133 through any vein. Return to. In other words, when the blood circulation system is considered as an electric circuit, as shown in FIG. 2, the heart that pumps blood is connected to the power source 105, the organs of the living body, and blood vessels of tissues such as the brain, extremities, muscles, and skin. The arteries to be connected are the circuit 106, the electrical resistances 107a to 107e in which the vascular resistance in each tissue such as each organ, brain, limb, muscle, and skin of the living body is connected in parallel to the power source 105, each organ, brain, limb, muscle in the living body The vein connecting the blood vessel of the tissue such as the skin and the heart is the circuit 108, the blood pressure of the living body is the voltage of the power source 105, and the blood vessels and veins of the tissues such as the organs, brain, extremities, muscles and skin from the artery to the living body. It can be simulated that the blood that passes back to the heart is the current 109 that flows through the entire electrical circuit 110.

  Therefore, if the vascular resistance of the peripheral blood vessel and the change in the blood flow flowing through the peripheral blood vessel are known in a part of the peripheral blood vessels distributed in parallel, the fluctuation of the blood pressure value, which is the product thereof, can be known. However, peripheral vascular resistance, that is, vascular resistance of arterioles, is changed by contraction of muscle fibers of arterioles accompanying the action of autonomic nerves. The influence of the autonomic nervous system appears due to various factors such as tension, relaxation, stress, and breathing. Therefore, when the blood flow is measured in the peripheral part of the living body, the blood flow rate is changed not only by the cardiac output and the pulsation within one beat but also by the change in the peripheral vascular resistance. Such an influence of the autonomic nervous system affects blood pressure fluctuations through peripheral vascular resistance and changes in blood flow, and thus is not preferable when measuring continuous blood pressure.

  Therefore, in the blood pressure measurement device and the blood pressure measurement device control method according to the present invention, the vascular resistance in the local region of the peripheral blood vessels distributed in parallel is maintained constant by pressurization, and the change in blood flow flowing in the pressurized local region is detected. We decided to estimate blood pressure. That is, the current value of the current flowing through the electrical resistor 107c is obtained under the condition that the resistance value of one of the electrical resistors 107a to 107e in FIG. 2 (for example, the electrical resistor 107c) is constant, and the voltage value is calculated. be equivalent to.

  Specifically, the blood pressure measurement device according to the present invention comprises a peripheral vascular resistance maintaining unit that maintains an average value of a peripheral vascular resistance of a peripheral blood vessel of a subject during a pulse, and the peripheral vascular resistance maintaining unit. Blood flow change detecting means for detecting a change in blood flow of the blood flowing in the peripheral blood vessel in which peripheral vascular resistance is maintained, and estimating the blood pressure value of the subject from the blood flow change detected by the blood flow change detecting means A blood pressure measuring device.

  According to the blood pressure measurement device of the present invention, it is possible to measure blood pressure stably with low noise and less burden on the subject.

  In the blood pressure measurement device, the peripheral vascular resistance maintaining means includes an outer ear mounting portion that is attached to the outer ear that is a part of the subject and pressurizes the outer ear, and controls the pressure applied to the outer ear by the outer ear mounting portion. Thus, it is desirable to maintain the average value of the peripheral vascular resistance of the peripheral blood vessels in the outer ear during a pulse in a substantially constant manner.

  With the blood pressure measurement device of the present invention, the blood pressure value at the head position can be stably measured with low noise.

  Further, in the blood pressure measurement device, the peripheral vascular resistance maintaining means pressurizes the subject, and an average volume during a pulse of the peripheral blood vessel under the pressurized portion to which the subject is pressurized becomes substantially constant. In this way, it is desirable to maintain the average value of the peripheral vascular resistance during one pulse to be substantially constant by controlling the pressure applied to the subject.

Further, in the blood pressure measurement device, the peripheral vascular resistance maintaining means may calculate the pulse volume of the instantaneous blood volume of the peripheral blood vessel under the pressurized portion as an average volume during the pulse of the peripheral blood vessel under the pressurized portion. It is desirable to calculate the average value.

In the blood pressure measurement device, it is preferable that the peripheral vascular resistance maintaining unit calculates an average value of the instantaneous blood volume in the peripheral blood vessel during one pulse from the blood flow detected by the blood flow change detecting unit.

  Further, in the blood pressure measurement device, the peripheral vascular resistance maintaining means irradiates outgoing light under the pressurized part, and transmitted light that has passed through the subject out of the outgoing light emitted under the pressurized part or A photoelectric sensor that receives scattered light scattered inside the subject is provided to the subject so that the average received light amount of the transmitted light or scattered light of the photoelectric sensor during a pulse of a peripheral blood vessel is constant. It is desirable to control the applied pressure.

  Further, in the blood pressure measurement device, the peripheral vascular resistance maintaining means maintains a blood flow change by the blood flow change detecting means when maintaining an average value of the peripheral vascular resistance of the peripheral blood vessels in a single pulse. It is desirable to occlude the capillaries involved in detection.

  Further, in the blood pressure measurement device, the peripheral vascular resistance maintaining means may maintain the pressure higher than a pressure that pressurizes the subject and closes the capillaries under the pressurized portion to which the subject is pressurized. desirable.

  Further, in the blood pressure measurement device, the blood flow rate change detecting means irradiates irradiation light under the pressurized portion, and reflects reflected light reflected by the subject out of the irradiated light irradiated under the pressurized portion. It is desirable to provide a blood flow sensor that receives light and detects a change in blood flow of blood flowing into the peripheral blood vessel of the subject from the Doppler shift amount of the reflected light with respect to the irradiation light.

  In the blood pressure measurement device, the blood flow rate change detecting unit detects a blood flow rate of blood flowing inside the peripheral blood vessel of the subject, and the blood pressure estimating unit is detected by the blood flow rate change detecting unit. It is desirable to calculate the blood pressure value of the subject by multiplying the blood flow volume by the resistance value of the peripheral vascular resistance maintained by the peripheral vascular resistance maintaining means.

  In the blood pressure measuring device, the blood pressure estimating means is calculated by multiplying the blood flow detected by the blood flow change detecting means and the resistance value of the peripheral vascular resistance maintained by the peripheral vascular resistance maintaining means. It is desirable to correct the difference between the blood pressure value and the blood pressure value measured by the standard measurement method.

  Here, the standard measurement method includes a direct method using a catheter, a Kafkorotkov method, a cuff oscillometric method, a palpation method, a flash method, an ultrasonic method, a volume vibration method, a volume compensation method, a tonometry method, and the like.

  Further, the blood pressure measurement device control method according to the present invention causes the peripheral vascular resistance maintaining means to maintain an average value of the peripheral vascular resistance of the peripheral blood vessel of the subject during a single pulse substantially constant, and the peripheral vascular resistance maintaining means The blood flow change in the blood flowing in the peripheral blood vessel in which the peripheral vascular resistance is maintained is detected by the blood flow change detecting means, and the blood pressure value of the subject is determined from the blood flow change detected by the blood flow change detecting means. This is a blood pressure measurement device control method to be estimated by the estimation means.

  According to the blood pressure measurement device control method of the present invention, it is possible to stably measure blood pressure with low noise and less burden on the subject.

  In the blood pressure measurement device control method, the peripheral vascular resistance maintaining means controls the pressure applied to the outer ear of an outer ear mounting portion that is attached to the outer ear that is a part of the subject and pressurizes the outer ear, thereby controlling the outer ear. It is desirable to maintain the average value of the peripheral vascular resistance of the peripheral blood vessels during a single pulse in a substantially constant manner.

  By the blood pressure measurement device control method of the present invention, the blood pressure value at the head position can be stably measured with low noise.

  Further, in the blood pressure measurement device control method, the peripheral volume of the peripheral blood vessel under the pressurized portion of the subject to be pressurized by the peripheral vascular resistance maintaining means is approximately constant in the peripheral vascular resistance maintaining means. It is desirable to control the pressure applied to the subject so that the average value of the peripheral vascular resistance during one pulse is maintained substantially constant.

  Further, in the blood pressure measurement device control method, the peripheral blood vessel resistance maintaining means may be configured to cause the peripheral blood vessel under the pressurized portion to have an average volume during a pulse of the peripheral blood vessel, and the instantaneous blood volume pulse of the peripheral blood vessel under the pressurized portion. It is desirable to calculate an average value during one beat.

  In the blood pressure measurement device control method, the peripheral vascular resistance maintaining unit may calculate an average value of the instantaneous blood volume of the peripheral blood vessel during one pulse from the blood flow detected by the blood flow change detecting unit. desirable.

  In the blood pressure measurement device control method, the peripheral vascular resistance maintaining means receives transmitted light transmitted through the subject or scattered light scattered inside the subject out of light irradiated on the subject. It is desirable to control the pressure applied to the subject so that the average received light amount of the transmitted light or scattered light during a pulse of the peripheral blood vessel of the photoelectric sensor is constant.

  Further, in the blood pressure measurement device control method, when the peripheral vascular resistance maintaining means maintains the average value of the peripheral vascular resistance of the peripheral blood vessels in a single pulse, the peripheral vascular resistance maintaining means, It is desirable to occlude capillaries related to detection of blood flow change by the blood flow change detection means.

  Further, in the blood pressure measurement device control method, the peripheral vascular resistance maintaining means maintains the pressure under the pressurized portion of the subject to be pressurized by the peripheral vascular resistance maintaining means at a pressure higher than the pressure at which the capillaries are blocked. It is desirable to make it.

  Further, in the blood pressure measurement device control method, the blood flow rate change detection unit receives reflected light reflected by the subject out of the irradiation light irradiated to the subject, and the Doppler shift of the reflected light with respect to the irradiated light It is desirable to detect a change in blood flow volume of blood flowing into the peripheral blood vessel of the subject from the amount.

  Further, in the blood pressure measurement device control method, the blood flow rate change detecting unit detects the blood flow rate of blood flowing in the peripheral blood vessel of the subject, and the blood pressure estimating unit detects the blood flow rate change detecting unit. It is desirable to calculate the blood pressure value of the subject by multiplying the blood flow volume thus obtained and the resistance value of the peripheral vascular resistance maintained by the peripheral vascular resistance maintaining means.

  Further, in the blood pressure measurement device control method, the blood pressure estimation means is calculated by multiplying the blood flow detected by the blood flow change detection means and the resistance value of the peripheral vascular resistance maintained by the peripheral vascular resistance maintenance means. It is desirable to correct the difference between the measured blood pressure value and the blood pressure value measured by the standard measurement method.

  With the blood pressure measurement device and the blood pressure measurement device control method according to the present invention, the physical burden on the subject is small, it is possible to measure other than a finger that is easy to move, and blood pressure can be measured stably for a long time.

  Embodiments of the present invention will be described with reference to the accompanying drawings. The embodiment described below is an example of the configuration of the present invention, and the present invention is not limited to the following embodiment.

(First embodiment)
FIG. 3 shows a schematic configuration diagram of the blood pressure measurement device 111 according to the present embodiment.

  The blood pressure measurement device 111 in FIG. 3 includes peripheral vascular resistance maintaining means for maintaining an average value of the peripheral vascular resistance of the arteriole 82 (peripheral blood vessel) of the subject 120 during one pulse, and peripheral vascular resistance maintaining means. The blood flow rate change detecting means for detecting the blood flow change of the blood 85 flowing inside the arteriole 82 in which the peripheral vascular resistance is maintained, and the blood pressure value of the subject 120 from the blood flow change detected by the blood flow change detecting means. Blood pressure estimating means for estimating.

  In the present embodiment, as peripheral vascular resistance maintaining means, a pressurizing means 11 (11a and 11b in FIG. 3; the same applies hereinafter) for pressurizing the subject 120, and the inside of the pressurizing means 11 by sending air to the pressurizing means 11 A pump 61 for increasing the pressure of the pressure, a valve 63 for discharging the air inside the pressurizing means 11 and reducing the pressure inside the pressurizing means 11, and a portion under the pressurized portion of the subject 120 pressurized by the pressurizing means 11. The photoelectric sensor 22 that receives the scattered light 91b scattered inside the arteriole 82 out of the emitted light 91a irradiated on the pressure sensor 11 and the pressurizing means 11 by controlling the pump 61 and the valve 63 based on the amount of light received by the photoelectric sensor 22. And a control unit 64 for controlling the pressure applied to the subject 120. The control unit 64 also has a function of estimating the blood pressure of the subject 120 as will be described later.

  The pressurizing unit 11 is a cuff that wraps around the arm, foot, or finger of the living body that is the subject 120 and pressurizes the arm with the air pressure inside the pressurizing unit 11, or the arm, foot, or finger of the living body that is the subject 120. Or the cuff which pressurizes with the air pressure inside the pressurization means 11 from right and left across the outer ear can be applied. In this embodiment, the pressurizing unit 11 pressurizes the subject 120 with the air pressure inside the pressurizing unit 11, but it may be a specific gas instead of air, or the hydraulic pressure inside the pressurizing unit 11. Alternatively, the subject 120 may be pressurized by water pressure. When the subject 120 is pressurized by the air pressure inside the pressurizing means 11, the pressure on the subject can be adjusted with a simple configuration by taking in air from the outside. Further, when the subject 120 is pressurized by the hydraulic pressure or the water pressure inside the pressurizing means 11, the pressing force applied to the subject 120 can be adjusted quickly. This is because pressurization by hydraulic pressure or water pressure can output a pressure stronger than that of air, so that pressurization to a set pressure and decompression can be performed quickly.

  The pump 61 sends air into the pressurizing means 11 through the pipe 52 in response to a command from the control unit 64 described later. Thereby, since the pressure inside the pressurizing unit 11 increases, the pressurizing unit 11 can increase the pressure applied to the subject 120. The valve 63 discharges air discharged from the inside of the pressurizing means 11 through the pipe 52 from the exhaust pipe 53 in response to a command from the control unit 64 described later. Since the pressure inside the pressurizing unit 11 decreases due to the discharge of air, the pressurizing unit 11 can reduce the pressure applied to the subject 120. In the present embodiment, the pump 61 delivers air, but when the pressurizing unit 11 pressurizes the subject 120 by the water pressure or hydraulic pressure inside the pressurizing unit 11, it depends on the pressurizing method. Water or oil. Similarly, the valve 63 also discharges air. However, when the pressurizing unit 11 pressurizes the subject 120 by the water pressure or hydraulic pressure inside the pressurizing unit 11, it depends on the pressurizing method. We will drain water or oil.

  The photoelectric sensor 22 includes a light emitting element 14 that emits the emitted light 91a toward a portion under the pressure of the subject 120 that is pressurized by the pressurizing unit 11, and the inside of the arteriole 82 of the emitted light 91a emitted from the light emitting element 14. And a light receiving element 15 that receives the scattered light 91b scattered in step S1. As the light emitting element 14, for example, a laser diode or LED can be applied, and the laser light or LED light as the emitted light 91 a is irradiated below the pressurized portion of the subject 120 pressurized by the pressurizing means 11. Further, a photodiode can be applied as the light receiving element 15, and an electric signal corresponding to the amount of received scattered light 91b is output to the control unit 64. The photoelectric sensor 22 and the control unit are connected by a signal line 51b. In the present embodiment, the light-emitting element 14 and the light-receiving element 15 are provided inside the pressurizing unit 11. However, if the light-emitting element 14 can be irradiated under the pressurized portion of the subject 120 pressurized by the pressurizing unit 11, It can be provided at any position. Further, the light receiving element 15 can be provided at any position as long as it can receive the scattered light 91b. In the present embodiment, the light receiving element 15 receives the scattered light 91b. However, the light receiving element 15 may receive the transmitted light transmitted through the subject 120. In this case, the light receiving element 15 is provided so as to face the light emitting element 14, for example. In the present embodiment, since the light receiving element 15 is provided on the subject 120, the light receiving element 15 receives scattered light 91 b scattered inside the subject 120 and emitted from the subject 120.

  The control unit 64 is configured so that the magnitude of the electrical signal from the light receiving element 15 of the photoelectric sensor 22 is constant, that is, the average amount of light received in the pulse of the scattered light 91b in the light receiving element 15 is constant. The pressure applied to the subject 120 is controlled by adjusting the air supply amount of the pump 61 and the air discharge amount of the valve 63. The intensity of the scattered light 91b differs depending on the thickness of the blood vessel of the arteriole 82. When the light from the light emitting element 14 is reflected by blood, the intensity of the scattered light 91b is larger as the blood vessel is thicker, and the intensity of the scattered light 91b is smaller as the blood vessel is thinner. On the contrary, when the light from the light emitting element 14 is absorbed by blood, the intensity of the scattered light 91b is smaller as the blood vessel is thicker, and the intensity of the scattered light 91b is larger as the blood vessel is thinner. As described above, the intensity of the scattered light 91b changes according to the amount of scattered light 91a emitted from the light emitting element 14 in the blood vessel of the arteriole 82. The same applies to the case where the light receiving element 15 receives not the scattered light 91b but the transmitted light transmitted through the subject 120. When the control unit 64 controls the pressure applied to the subject 120 so that the average amount of light received in the pulse of the scattered light 91b of the light receiving element 15 is constant, the volume of the arteriole 82 is made substantially constant, that is, the fine volume is reduced. The blood vessel diameter of the artery 82 can be made substantially constant. Since the vascular resistance of the arteriole 82 is determined by the vascular diameter of the vasculature of the arteriole 82, as described above, the subject is measured so that the average amount of light received in the pulse of the scattered light 91b in the light receiving element 15 is constant. By controlling the pressure applied to 120, the control unit 64 maintains the average value of the vascular resistance of the blood vessels of the arteriole 82 during one pulse regardless of the influence of the autonomic nervous system of the subject 120. be able to.

In addition, the control unit 64 may detect blood cell components that move at a predetermined speed or more from the electrical signal from the light receiving element 15, calculate the instantaneous blood volume of the arteriole 82 from the sum, and calculate the volume of the arteriole 82. it can. In this calculation method, the control system is configured by regarding the instantaneous blood volume of the arteriole 82 as the “volume of the arteriole 82 (peripheral blood vessel)”. Here, the predetermined speed is an upper limit speed considered to be stationary among the speeds of the blood cells 84 calculated from the Doppler shift of the reflected light 90b. For example, the predetermined speed is approximately 2.0 mm / s. That is, the component that moves at approximately 2.0 mm / s or more in the blood cell 84 is set as the blood cell to be detected, and the instantaneous blood volume can be detected from the sum of the components. The instantaneous blood volume is a value that can be calculated by converting the electric signal from the light receiving element 15 into a power spectrum in the control unit 64 and then integrating the power spectrum. The control unit 64 controls the pressure applied to the subject 120 by operating the pump 61, the pressure sensor 62, and the valve 63 so that the average value calculated during the pulse of the instantaneous blood volume of the blood vessel is constant. Thus, the blood vessel diameter of the arteriole 82 can be made substantially constant, and the average value of the vascular resistance of the blood vessel of the arteriole 82 can be kept substantially constant regardless of the influence of the autonomic nervous system of the subject 120. it can. Note that a laser diode is preferable as the light emitting element in measuring the Doppler shift.

  Further, in the present embodiment, the reflected light 90b reflected by the subject 120 among the irradiated light 90a irradiated under the pressurized portion pressurized by the pressurizing means 11 of the subject 120 is received as the blood flow change detecting means. The blood flow sensor head 21, the pressure sensor 62 that detects the pressure inside the pressurizing unit 11, and the subject 120 of the pressurizing unit 11 by controlling the pump 61 and the valve 63 based on the detected pressure from the pressure sensor 62. And a control unit 64 for controlling the pressure applied to the. Further, the control unit 64 detects a change in the blood flow rate of the blood 85 flowing inside the arteriole 82 of the subject 120 from the Doppler shift amount of the reflected light 90b with respect to the irradiation light 90a based on the electrical signal from the blood flow sensor head 21. It also has a function to do.

  The blood flow sensor head 21 includes a light emitting element 12 that emits irradiation light 90a toward a portion under pressure to be pressurized by the pressurizing unit 11 of the subject 120, and an arteriole 82 of the irradiation light 90a from the light emitting element 12. And a light receiving element 13 that receives the reflected light 90b. As the light emitting element 12, for example, a laser diode can be applied, and the laser light as the irradiation light 90 a is irradiated below the portion to be pressurized of the subject 120 to be pressurized by the pressurizing unit 11. Moreover, a photodiode can be applied as the light receiving element 13, and an electric signal corresponding to the amount of received light of the reflected light 90b is output to the control unit 64. The blood flow sensor head 21 and the control unit 64 are connected by a signal line 51a. In the present embodiment, the light emitting element 12 and the light receiving element 13 are provided inside the pressurizing unit 11. However, if the light emitting element 12 can be irradiated under the pressurized portion of the subject 120 pressurized by the pressurizing unit 11, It can be provided at any position. The light receiving element 13 can also be provided at any position as long as it can receive the reflected light 90b. In the present embodiment, since the light receiving element 13 is provided on the subject 120, the light receiving element 13 receives the reflected light 90 b reflected from the subject 120 and emitted from the subject 120.

  The blood 85 flows inside the arteriole 82, and the irradiation light 90a is reflected by the blood cell 84 contained in the blood 85 flowing inside the arteriole 82 to become reflected light 90b. The reflected light 90b undergoes a frequency shift according to the velocity of the blood cell 84, that is, the velocity of the blood flow, due to the wave Doppler effect. By detecting this frequency shift amount, the blood flow velocity of the blood 85 flowing inside the arteriole 82 can be obtained, and the change in the blood flow amount can be obtained from the change in the blood flow velocity. Specifically, the control unit 64 can obtain the blood flow volume by obtaining the power spectrum of the electrical signal from the light receiving element 13 and multiplying and integrating the frequency.

  The pressure sensor 62 detects the pressure of the air inside the pressurizing means 11 through the pipe 52. For example, a piezoelectric pressure sensor can be applied. Here, when the control unit 64 maintains the average value of the blood vessel resistance of the blood vessels of the arteriole 82 during a pulse, the control unit 64 sets the capillaries 81 related to the detection of the change in blood flow by the blood flow sensor head 21. It is desirable to occlude. Specifically, the control unit 64 maintains the pressure of the air inside the pressurizing unit 11 to be equal to or higher than the pressure at which the capillaries 81 are blocked according to the detected pressure from the pressure sensor 62. The pressure enough to occlude the capillary blood vessel 81 can be examined in advance experimentally. In the present embodiment, the pressure is detected so as to block the capillary blood vessel 81 based on the pressure detected by the pressure sensor 62. For example, the amount of noise becomes a certain value or less based on the amount of noise from the blood flow sensor head 21. The pressure can be set to such a pressure that the capillary 81 is occluded. The control unit 64 maintains the pressure of the air inside the pressurizing means 11 to be equal to or higher than the pressure at which the capillary blood vessels 81 are blocked, so that the blood vessel resistance of the arteriole 82 is made substantially constant by pressurization and at the same time Can be occluded. Further, by blocking the capillary blood vessel 81, it is possible to eliminate blood flow in the capillary blood vessel 81, which can be noise when measuring the blood flow amount flowing inside the arteriole 82, and blood flow estimation accuracy for estimating blood pressure. Can be improved.

  Even if the capillaries related to the detection of the change in blood flow, that is, the capillaries 81 under the pressurized portion by the pressurizing means 11 of the subject 120 are blocked, the blood flow itself is not inhibited by the anastomosis of the capillaries 81. Absent. A blood vessel anastomosis means that a plurality of blood vessels communicate with each other.

  In the present embodiment, the blood pressure estimation unit includes a control unit 64 that estimates the blood pressure value of the subject 120 from the change in blood flow in the arteriole 82 detected based on the electrical signal from the light receiving element 13. Since the vascular resistance of the arteriole 82 is maintained substantially constant by the pressurizing means 11, the control unit 64 can estimate the blood pressure value of the subject 120 by measuring a change in blood flow. Specifically, the blood flow volume of the arteriole 82 detected based on the electrical signal from the light receiving element 13 is multiplied by the resistance value of the vascular resistance of the arteriole 82 maintained by the pressurizing means 11. Estimate blood pressure.

  In this embodiment, since the peripheral vascular resistance varies depending on each person, an accurate blood pressure value may be obtained by correcting a difference from the blood pressure value measured by the standard measurement method. Specifically, the control unit 64 stores in advance the difference between the standard measurement method and the blood pressure value obtained by the above-described measurement, and adds the blood flow rate of the arteriole 82 detected based on the electrical signal from the light receiving element 13. The blood pressure value of the subject 120 is obtained by multiplying the resistance value of the vascular resistance of the arteriole 82 maintained by the pressure means 11, and then the stored difference value is added to calculate an accurate blood pressure value. . Further, for example, correction may be performed using a linear expression or a multi-order expression.

  The blood pressure measurement device 111 may have a function of measuring a blood pressure value by the standard measurement method. By providing such a function, the difference between the standard measurement method and the blood pressure value obtained by the above-described measurement can be easily obtained in advance.

  In this apparatus, since a pressurization site | part may be small, an apparatus can be reduced in size and weight. Moreover, since it is sufficient to control the pressurization with a cycle slower than the pulsation, the apparatus can be simplified. Furthermore, blood pressure can be measured by using a finger other than a mobile finger.

  As described above, the blood pressure measurement device can measure blood pressure with a low physical burden and a low noise with little physical burden on the subject.

  Next, FIG. 4 shows a flowchart of the blood pressure measurement device control method according to the present embodiment. In FIG. 4, step S1 is a step of measuring a blood pressure value by a standard measurement method, and a blood flow rate is measured by the present blood pressure measuring device, and step S2 is a peripheral blood vessel resistance value calculated from the blood pressure value and the blood flow rate described above. Step S3 is a step of obtaining a target value of the average amount of light received during one pulse of the light receiving element in order to make the average arteriole blood vessel diameter during one pulse in the pressurized portion substantially constant. S4 is a step of adjusting the pressure so that the average value of the average amount of light received during one pulse of the light receiving element coincides with the target value, step S5 is a step of measuring the blood flow, and step S6 is the previously obtained peripheral vascular resistance. A step of estimating the blood pressure value from the value, step S7 is a step of correcting the blood pressure value obtained in step S6 from the blood pressure value measured by the standard measurement method and the blood flow, and step S8 is a measurement. It is a step to determine whether Ryosuru.

  Step S1 is a step of measuring the blood pressure value by the standard measurement method and the blood flow rate by the present blood pressure measuring device. Since the peripheral vascular resistance is different for each person, the blood pressure value and the blood flow are measured in advance by a standard measurement method in step S1 before performing continuous blood pressure measurement. Of the standard measurement methods, the blood pressure measurement site by a single measurement may be the upper arm or the wrist, but since the blood pressure value at the head position can be obtained by measuring with the tragus, it is optimal from the viewpoint of preventing cerebrovascular disorders. is there. For this reason, the blood pressure value is measured in advance with a blood pressure monitor employing a standard measurement method, for example, the cuff oscillometric method, and the blood flow rate is measured with the present blood pressure measurement device. If the blood pressure measurement device has a blood pressure measurement function based on the standard blood pressure method, the blood pressure value can be measured using the standard blood pressure measurement device. In this step, the subject is preferably in a sitting position.

  In step S2, the blood flow rate and blood pressure value described above are measured and stored in the control unit of the blood pressure measurement device. In FIG. 4, step S1 and step S2 are executed before step S3, but step S1 and step S2 need only be executed before step S6.

  In step S3, the target value of the amount of light received by the light receiving element is acquired in order to make the average arteriole blood vessel diameter during one pulse in the pressurized portion approximately constant. At this time, it is desirable that the subject is in a sitting position and the pressure applied to the pressurized portion is such that the capillaries of the pressurized portion are blocked. In this state, the average value per pulse of the received light amount obtained from the photoelectric sensor is set as a target value for pressurization control during continuous measurement.

  Steps S4 to S6 are the continuous measurement mode. In step S4, pressurization adjustment is performed so that the average value of the amount of received light during one pulse beats the target value. In the pressurization adjustment, the peripheral vascular resistance maintaining means maintains the average value of the peripheral vascular resistance of the subject during one pulse in a substantially constant manner. Specifically, the pressure on the subject is controlled so that the average volume during the pulse of the peripheral blood vessel of the subject is constant, and the average value of the peripheral vascular resistance during the pulse is maintained substantially constant. For example, the photoelectric sensor receives light transmitted through the subject or scattered light scattered inside the subject out of the light irradiated to the subject, and the average amount of light received in the pulse of transmitted light or scattered light is The pressure applied to the subject is controlled to be constant. When maintaining the average value of the peripheral vascular resistance of the peripheral blood vessel during a single pulse, it is desirable to block the capillary vessel with the peripheral vascular resistance maintaining means, and in particular, maintain the pressure higher than the pressure to block the capillary vessel. It is desirable. In a control system that controls the pressure applied to a subject so that the average amount of light received during a pulse is constant in order to maintain the average value of the peripheral vascular resistance of the peripheral blood vessels during a pulse, There should be a response speed that follows changes in the autonomic nervous system such as tension, relaxation, stress, and breathing. For example, it is around 1 second.

  In step S5, the blood flow is measured. The blood flow rate change detecting means detects the blood flow rate change of the blood flowing in the peripheral blood vessel in which the peripheral blood vessel resistance is maintained by the peripheral blood vessel resistance maintaining means. The change in blood flow is caused by causing the blood flow change detection means to receive the reflected light reflected by the subject out of the irradiation light emitted to the subject, and to enter the peripheral blood vessel of the subject from the Doppler shift amount of the reflected light with respect to the irradiated light. What is necessary is just to detect the blood flow rate change of the flowing blood flow. Changes in blood flow are measured at regular intervals, and the measurement frequency is mainly governed by the calculation time of the blood flow meter, but it is sufficient if it is sufficiently fast compared to changes in the autonomic nervous system. For example, the interval is 0.02 seconds.

  In step S6, the blood pressure estimation means is made to estimate the blood pressure value of the subject from the change in blood flow obtained in step S5. Specifically, the blood pressure value is calculated by multiplying the blood flow detected by the blood flow change detecting means in step S5 and the resistance value of the peripheral vascular resistance. By making the peripheral vascular resistance of the subject substantially constant, the change in blood flow accompanying pulsation reflects the change in stroke volume, and as a result, the change in blood pressure value can be obtained. The maximum and minimum values of blood flow during a single pulse reflect the systolic blood pressure value and the diastolic blood pressure value during the same pulse. Since this method can estimate systolic blood pressure values and diastolic blood pressure values for each pulse, the blood pressure value of a subject is measured by a standard measurement method before, during or after the start of measurement. Peripheral vascular resistance can be obtained by calculating the relationship between blood pressure and blood flow.

  If necessary, step S7 may be provided to correct the blood pressure value obtained in step S6 from the blood pressure value measured by the standard measurement method. The blood pressure value can be obtained more accurately by the correction. In FIG. 4, step S7 is executed between step S4 and step S8. However, step S7 may be executed after step S8 when the continuous measurement mode ends.

  Finally, in step 8, a measurement end determination is made. If YES, the measurement ends, and if NO, the process returns to step S4.

  According to this method, the pressure applied to the pressurized part is controlled so that the average value of the peripheral blood vessel resistance of the peripheral blood vessel under the pressurized part during one pulse is substantially constant. Therefore, it is not necessary to control the pressure on the subject to a strictly determined value, which makes it easy to attach to the subject. Moreover, since it is sufficient to control the pressurization at a cycle slower than the pulsation, high-speed control is not necessary.

(Second embodiment)
FIG. 5 shows a schematic configuration diagram of the blood pressure measurement device 112 according to the present embodiment.

  The blood pressure measurement device 112 of FIG. 5 includes a mounting portion 70 and a main body portion 71 that are attached to the outer ear of the subject, in particular, the tragus. The mounting unit 70 includes a first arm 31, a second arm 32, a first cuff 18 a mounted on the first arm, a second cuff 18 b mounted on the second arm, and the first arm 31. And the angle of the second arm 32 to adjust the angle between the first cuff 18a and the second cuff 18b and pressurize the tragus between the first cuff 18a and the second cuff 18b. A blood flow sensor head 21 and a photoelectric sensor 22 incorporated in a second cuff are provided.

  The main body 71 has a pump 61 for sending air to the first cuff 18a and the second cuff 18b and increasing the internal pressure, and discharges the air inside the first cuff 18a and the second cuff 18b A pressure sensor 62 for detecting the internal pressure of the pump 61, the first cuff 18a and the second cuff 18b based on the amount of light received by the photoelectric sensor 22, and the pressure sensor 62, the first cuff 18a and the first cuff 18a. An exhaust pipe 53 for discharging air discharged from the inside of the second cuff 18b through the pipe 52 to the outside, and a battery 65 and a valve for supplying a DC voltage to the electrical system of the blood pressure measurement device 112 so as to be portable The control part 64 which controls 63 and controls the pressurization force to the subject by the cuff 18a and the cuff 18b is provided. The controller 64 also has a function of estimating the blood pressure of the subject as will be described later. The control unit 64 also has a function of detecting a change in blood flow volume based on an electrical signal from the blood flow sensor head 21.

  The mounting portion 70 and the main body portion 71 are connected via signal lines 51a and 51b. The signal line 51 a connects the blood flow sensor head 21 and the control unit 64. The signal line 51 b connects the photoelectric sensor 22 and the control unit 64. The exhaust pipe 52 connects the first cuff 18 a and the second cuff 18 b to the pump 61, the pressure sensor 62, and the valve 63.

  The mounting portion 70 and the main body portion 71 may be an integrated type or a separate type. Moreover, you may supply electric power from AC power supply irrespective of the electric power supply from the battery 65. FIG.

  In FIG. 5, the joint portion 35 varies the angle α between the first arm 31 and the second arm 32. This variable mechanism makes it easy to attach to the tragus with individual differences. Although the photoelectric sensor 22 is disposed in one cuff and the blood flow sensor head 21 is disposed in the other cuff, both may be disposed in one cuff, or a part of the photoelectric sensor 22 or the blood flow sensor. A part of the head 21 may be arranged separately. The cuff inserted into the ear canal may be the first cuff 18a or the second cuff 18b, but it is desirable that the cuff in which the blood flow sensor head 21 is disposed is inserted into the ear canal.

  The blood pressure measurement mechanism and procedure in the blood pressure measurement device 112 are the same as the flow of the blood pressure measurement mechanism and blood pressure measurement device control method in the blood pressure measurement device 111 described in the first embodiment.

  The blood pressure measurement device 112 may store the blood pressure value calculated from the blood flow volume in a storage unit (not shown). Moreover, you may display a blood-pressure value on the display part which is not shown in figure. Further, the blood pressure value may be transmitted to the outside by a transmission unit not shown. By providing such a mechanism, the subject can refer to blood pressure value data accumulated for his / her own health maintenance and health examination.

  As described above, since this blood pressure measurement device can be easily worn on the outer ear, the blood pressure value at the head position can be continuously measured stably for a long time.

(Third embodiment)
FIG. 6 shows a schematic configuration diagram of the blood pressure measurement device 113 according to the present embodiment. In addition, about the component with the same code | symbol as the blood pressure measurement apparatus 111 demonstrated in FIG. 2, description is abbreviate | omitted since it shows the same thing mutually.

  6 is provided with a control unit 66 in place of the control unit 64 of the blood pressure measurement device 111 in FIG. 2, which makes it possible to omit the photoelectric sensor 22 in FIG. 2. This is different from the blood pressure measurement device 111. Note that the pump 61, the pressure sensor 62, and the valve 63 perform the respective functions in response to commands from the control unit 66, as in the case of the control unit 64 in FIG.

  The control unit 66 calculates the instantaneous blood volume of the blood 85 flowing into the arteriole 82 based on the electrical signal from the light receiving element 13, and applies to the subject 120 so that the average value of the calculated values is constant. The applied pressure is controlled by a pump 61, a pressure sensor 62 and a valve 63.

The blood pressure measurement device 113 utilizes the fact that the light emitting element 12 of the blood flow sensor head 21 is a laser diode, detects blood cell components that move at a predetermined speed or higher, and obtains the instantaneous blood volume of the arteriole 82 from the sum. The blood pressure measurement device 113 constitutes a control system by regarding the instantaneous blood volume of the arteriole 82 as the “volume of the arteriole 82 (peripheral blood vessel)” described in the first and second embodiments. Hereinafter, the “volume of arteriole 82 (peripheral blood vessel)” will be referred to as “blood vessel volume”. Here, the predetermined speed is the same as that of the first embodiment, and is, for example, approximately 2.0 mm / s. That is, the component that moves at approximately 2.0 mm / s or more in the blood cell 84 is set as the blood cell to be detected, and the instantaneous blood volume can be detected from the sum of the components. The instantaneous blood volume is a value that can be calculated by integrating an electric signal from the light receiving element 13 into a power spectrum in the control unit 66 and then integrating the power spectrum.

  As described above, in the blood pressure measuring device 113, the blood flow sensor head 21 used as the blood flow rate change detecting means in the blood pressure measuring device 111 in FIG. can do. Like the blood flow sensor head 21 of the blood pressure measurement device 111 in FIG. 2, the blood flow sensor head 21 naturally also has a function as a blood flow change detection means. It is possible to calculate the blood flow rate by a calculation process in the control unit 66. Therefore, the number of optical elements can be reduced as compared with the case where the instantaneous blood volume and the blood flow volume are detected by individual optical elements.

Comparing the instantaneous blood volume detection method of this embodiment with the blood vessel volume detection method of the first embodiment, in the first embodiment, the blood cell 84 in the blood 85 is used to detect the volume of the arteriole 82 in FIG. In the present embodiment, in order to detect the instantaneous blood volume in the arteriole 82 in FIG. 6, the velocity of the blood cell 84 that moves in the blood 85 is detected, and the sum of the velocity components is used. Instantaneous blood volume is detected. Therefore, it can be said that both are different in principle.

  FIG. 7 shows a flowchart of the blood pressure measurement device control method according to the present embodiment. In addition, about the step which attached | subjected the same step number as the flowchart demonstrated in FIG. 4, description is abbreviate | omitted as it shows the same step mutually.

In FIG. 7, only the point of FIG. 4 is a step of calculating the target value of the sum of blood cell components moving at a predetermined speed or higher in step S <b> 9 in order to make the average arteriole blood vessel diameter in a single pulse substantially constant. Is different. At this time, it is desirable that the subject is in a sitting position and the pressure applied to the pressurized portion is such that the capillaries of the pressurized portion are blocked. In this state, the average value of the instantaneous blood volume per pulse calculated from the blood flow obtained from the blood flow sensor head 21 in FIG. 6 is set as a target value for pressurization control during continuous measurement.

  A series of operations of step S10, step S5 and step S6 is a continuous measurement mode. In step S10, pressurization adjustment is performed so that the average value of the instantaneous blood volume during one pulse coincides with the target value. As a result, the pressure on the subject is controlled so that the average volume during the pulse of the peripheral blood vessel of the subject is constant, and the average value of the peripheral vascular resistance of the peripheral blood vessel during the pulse is maintained substantially constant. can do. When maintaining the average value of the peripheral vascular resistance of the peripheral blood vessel during a single pulse, it is desirable to block the capillary vessel with the peripheral vascular resistance maintaining means, and in particular, maintain the pressure higher than the pressure to block the capillary vessel. It is desirable. A control system that controls the pressure applied to the subject so that the average value of the instantaneous blood volume during a pulse is constant in order to maintain the average value of the peripheral blood vessel resistance of the peripheral blood vessel during the pulse. Then, it is only necessary to have a response speed that follows changes in the autonomic nervous system such as human tension, relaxation, stress, and respiration. For example, it is around 1 second.

(Fourth embodiment)
FIG. 8 shows a schematic configuration diagram of a blood pressure measurement device 114 according to the present embodiment. In addition, about the component with the code | symbol same as the blood pressure measuring apparatuses 112 and 113 demonstrated in FIG.5 and FIG.6, description is abbreviate | omitted as what shows the same thing mutually. Also in this embodiment, the blood pressure measurement device 114 regards the instantaneous blood volume of the peripheral blood vessel as the “volume of the peripheral blood vessel” described in the first and second embodiments, as in the third embodiment. Configure.

  The blood pressure measurement device 114 in FIG. 8 is a configuration example in the case where it is possible to measure blood pressure by attaching to the outer ear, like the blood pressure measurement device 112 in FIG. The blood pressure measurement device 114 is different from the blood pressure measurement device 112 of FIG. 5 in that the blood flow sensor head 21 has a function of detecting blood flow and a function of monitoring instantaneous blood volume. Thereby, the number of optical elements can be reduced compared with the case where the instantaneous blood volume and the blood flow volume are detected by individual optical elements.

  A blood pressure measurement device and a blood pressure measurement device control method according to the present invention include blood pressure measurement for safety management of a subject in a dangerous environment such as underwater action, blood pressure measurement for health maintenance and medical examination, or beauty. It can be used for blood pressure measurement in facilities and entertainment facilities.

Structure of subcutaneous blood vessels in living body Circuit configuration when mimicking the blood circulation system of a living body 1 is a schematic configuration diagram of a blood pressure measurement device according to an embodiment. Flow chart of blood pressure measurement device control method according to an embodiment 1 is a schematic configuration diagram of a blood pressure measurement device according to an embodiment. 1 is a schematic configuration diagram of a blood pressure measurement device according to an embodiment. Flow chart of blood pressure measurement device control method according to an embodiment 1 is a schematic configuration diagram of a blood pressure measurement device according to an embodiment.

Explanation of symbols

11a, 11b: pressurizing means 12: light emitting element 13: light receiving element 14: light emitting element 15: light receiving element 18a: first cuff 18b: second cuff 21: blood flow sensor head 22: photoelectric sensor 31: first Arm 32: Second arm 35: Joint part 51a, 51b: Signal line 52: Pipe 53: Exhaust pipe 61: Pump 62: Pressure sensor 63: Valve 64, 66: Control part 65: Battery 70: Mounting part 71: Main body Part 81: Capillary vessel 82: Arteriole (peripheral vessel)
84: Blood cell 90a: Irradiation light 90b: Reflected light 91a: Emission light 91b: Scattered light 105: Power supply 106, 108: Circuit 105: Power supply 107a to 107e: Electric resistance 109: Current 110: Electric circuit 111, 112: Blood pressure measuring device 120: subject 121: arterial region 122: arteriole region 123: capillary region 131: artery 132: arteriole 133: capillary vessel 134: vein 141: epidermis 142: dermis 143: subcutaneous tissue

Claims (19)

Peripheral vascular resistance maintaining means for maintaining the average value of the peripheral vascular resistance of the peripheral blood vessels of the subject during one pulse, substantially constant,
A blood flow rate change detecting means for detecting a blood flow rate change of the blood flowing in the peripheral blood vessel in which the peripheral vascular resistance is maintained by the peripheral vascular resistance maintaining means;
Blood pressure estimating means for estimating the blood pressure value of the subject from the blood flow change detected by the blood flow change detecting means;
A blood pressure measurement device comprising:   The peripheral vascular resistance maintaining means includes an outer ear mounting unit that is mounted on the outer ear that is a part of the subject and pressurizes the outer ear, and controls the pressure applied to the outer ear by the outer ear mounting unit to control the outer ear. The blood pressure measurement apparatus according to claim 1, wherein an average value of the peripheral blood vessel resistance of the peripheral blood vessel during one pulse is maintained substantially constant.   The peripheral vascular resistance maintaining means applies pressure to the subject so that an average volume during a pulse of a peripheral blood vessel under a pressurized portion to which the subject is pressurized is substantially constant. The blood pressure measuring device according to claim 1 or 2, wherein pressure is controlled to maintain an average value of the peripheral vascular resistance during one pulse in a substantially constant manner. The peripheral vascular resistance maintaining means calculates an average value during the pulse of the instantaneous blood volume of the peripheral blood vessel under the pressurized portion as an average volume during the pulse of the peripheral blood vessel under the pressurized portion. The blood pressure measuring device according to claim 3.   5. The blood pressure measurement according to claim 4, wherein the peripheral vascular resistance maintaining means calculates an average value of the instantaneous blood volume in the peripheral blood vessel during one pulse from the blood flow detected by the blood flow change detecting means. apparatus.   The peripheral vascular resistance maintaining means irradiates outgoing light under the pressurized portion and scatters the transmitted light transmitted through the subject or the inside of the subject of outgoing light irradiated under the pressurized portion. A photoelectric sensor for receiving scattered light, and controlling the pressure applied to the subject so that an average amount of the transmitted light or scattered light received by the photoelectric sensor during a pulse of a peripheral blood vessel is constant. The blood pressure measurement device according to claim 3, wherein   The peripheral vascular resistance maintaining means occludes capillaries related to detection of a change in blood flow by the blood flow change detecting means when maintaining an average value of the peripheral vascular resistance of the peripheral blood vessel during a pulse. The blood pressure measurement device according to claim 1, wherein the blood pressure measurement device is a blood pressure measurement device.   The said peripheral vascular resistance maintenance means maintains the pressure more than the pressure which pressurizes the said test object and obstruct | occludes the said capillary vessel under the to-be-pressurized part to which the said test object is pressurized. Blood pressure measuring device.   The blood flow rate change detecting means irradiates irradiation light under the pressurized portion, receives reflected light reflected by the subject out of irradiated light irradiated under the pressurized portion, and irradiates the reflected light. 9. A blood flow sensor for detecting a change in blood flow volume of blood flowing in the peripheral blood vessel of the subject from a Doppler shift amount with respect to light, comprising: a blood flow sensor; The blood pressure measurement device described.   The blood flow change detecting means detects a blood flow of blood flowing inside the peripheral blood vessel of the subject, and the blood pressure estimating means maintains the blood flow detected by the blood flow change detecting means and the peripheral vascular resistance. The blood pressure measurement device according to any one of claims 1 to 9, wherein the blood pressure value of the subject is calculated by multiplying the resistance value of the peripheral vascular resistance maintained by the means.   The blood pressure estimating means measures the blood pressure value calculated by multiplying the blood flow detected by the blood flow change detecting means and the resistance value of the peripheral vascular resistance maintained by the peripheral vascular resistance maintaining means by a standard measurement method. The blood pressure measurement device according to claim 10, wherein a difference from the blood pressure value is corrected.   The peripheral vascular resistance maintaining means maintains the average value of the peripheral vascular resistance of the subject's peripheral blood vessels during one pulse, and flows into the peripheral blood vessel in which the peripheral vascular resistance is maintained by the peripheral vascular resistance maintaining means. A blood pressure measurement device control method for causing a blood flow change detection means to detect a blood flow change, and causing the blood pressure estimation means to estimate a blood pressure value of the subject from the blood flow change detected by the blood flow change detection means.   The peripheral vascular resistance maintaining means controls the pressure applied to the outer ear of the outer ear mounting portion that is attached to the outer ear that is a part of the subject and pressurizes the outer ear, thereby controlling the peripheral vascular resistance of the peripheral blood vessel of the outer ear. The blood pressure measurement device control method according to claim 12, wherein an average value during one pulse is maintained substantially constant.   The peripheral vascular resistance maintaining means is subjected to a pressure applied to the subject so that an average volume during a pulse of a peripheral blood vessel under the pressurized portion of the subject to be pressurized by the peripheral vascular resistance maintaining means becomes substantially constant. The blood pressure measuring device control method according to claim 12 or 13, wherein the blood pressure measuring device is controlled to maintain an average value of the peripheral vascular resistance during one pulse in a substantially constant manner. Causing the peripheral vascular resistance maintaining means to calculate an average value during the pulse of the instantaneous blood volume of the peripheral blood vessel under the pressurized portion as an average volume during the pulse of the peripheral blood vessel under the pressurized portion. The blood pressure measurement method according to claim 14.   16. The blood pressure measurement according to claim 15, wherein the peripheral vascular resistance maintaining means calculates an average value of an instantaneous blood volume in the peripheral blood vessel during one pulse from a blood flow detected by the blood flow change detecting means. Method.   When the peripheral vascular resistance maintaining means maintains the average value of the peripheral vascular resistance of the peripheral blood vessels during one pulse, the peripheral vascular resistance maintaining means causes the blood flow change detection means to 13. The blood pressure measuring device control method according to claim 12, wherein capillaries related to detection are occluded.   18. The peripheral vascular resistance maintaining means maintains the pressure under the pressurized portion of the subject to be pressurized by the peripheral vascular resistance maintaining means at a pressure higher than the pressure at which the capillaries are blocked. The blood pressure measurement device control method described.   The blood flow change detecting means detects the blood flow of blood flowing in the peripheral blood vessel of the subject, and the blood pressure estimating means maintains the blood flow detected by the blood flow change detecting means and the peripheral vascular resistance. The blood pressure measurement device control method according to any one of claims 12 to 18, wherein the blood pressure value of the subject is calculated by multiplying the resistance value of the peripheral vascular resistance maintained by the means.

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