JP2008109989A - Medical patch products - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical patch having a favorable adhesion to a skin and a high moisture permeability, capable of preventing stuffiness and itch due to perspiration for a long period of time, and having a superior elasticity and superior pasting property to the skin. <P>SOLUTION: This medical patch comprises an adhesive layer at least on one face of a base material, which consists of a base material body having air permeability and moisture permeability, and an elastic member selected from groups formed of a sheet-like body knitted or woven with thread and an elastic fiber thread; and is characterized in that the thickness of the base material body is within 10-50 μ and at least 15% or more of the total thickness of the elastic member is embedded in the base material body. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a medical patch product such as an adhesive bandage, adhesive bandage, surgical tape and the like.

Conventionally, adhesive bandages, adhesive bandages, surgical tapes, and the like have been used as medical patch products, but medical patch products are required to have moisture permeability and breathability. That is, if there is not enough moisture permeability or breathability, if the medical patch product is pasted for a long time, evaporation of moisture from the skin surface is hindered by the medical patch product, and itching and rash may occur. is there.

In addition, when a medical patch product is directly applied to the skin, even if it has moisture permeability and breathability, if the medical patch product is wrinkled when the skin is applied, it may be uncomfortable. , Wrinkles, etc. may cause itching and rash. In addition, since it needs to be applied to the skin for a long time, the medical patch product is required to have good stretchability.

In general, as a method for imparting air permeability and moisture permeability to the medical patch product as described above, (1) a method of forming a through hole in the medical patch product, (2) benzoyl peroxide, etc. on an acrylic adhesive And a method of crosslinking at a high temperature, and (3) a method of blending an acrylic adhesive with a crosslinking agent and crosslinking at a high temperature.

  However, in the method (1), the production process is complicated and the productivity is poor. In the method (2), the odor due to the decomposition of peroxide is strong and the re-adhesiveness is poor. In the method (3), There was no problem such as odor, but there was a problem that the re-adhesiveness was poor.

Further, as a means for satisfying moisture permeability and ease of sticking, a medical sticking product in which an elastic net is laminated on a support (film) as a base material using an adhesive has been proposed (see Patent Document 1).
However, in the medical patch product in which the previously proposed support and net are sequentially laminated, the product becomes thick, so that sufficient moisture permeability cannot always be obtained. In addition, the bonding strength between the support and the net is weak, the tape peels off from the support and the net layer, the appearance is bad, and water enters from the gap between the support and the net, and from the skin during use. There were problems such as peeling.

Japanese Patent Laid-Open No. 7-31546

  In view of the above-mentioned drawbacks, the present invention has good adhesion to the skin and high moisture permeability, can prevent stuffiness and itching due to perspiration for a long time, has excellent stretchability, and can be applied to the skin. The purpose is to provide an excellent medical patch product.

  In order to achieve the above object, a medical patch product according to the present invention includes a base material body having air permeability or moisture permeability, a sheet-like body in which a yarn is knitted or woven, and an elastic fiber yarn. A medical patch product comprising a pressure-sensitive adhesive layer on at least one surface of a base material comprising a selected elastic member, wherein the thickness of the base body is in the range of 10 to 50 microns, At least 15% or more of the total thickness is buried in the base body.

  In the present invention, the medical patch product is not particularly limited, and examples thereof include adhesive bandages, poultices, dressing materials, adhesive bandages, surgical tapes, and the like, and also include adhesive sheets and adhesive films.

  The material of the base material is not particularly limited as long as it has breathability or moisture permeability that can prevent stuffiness and itching due to perspiration for a long time. For example, it is formed of silicone resin or urethane resin, etc. Single films of laminated moisture-permeable films or laminates of these films, or those obtained by mechanically perforating them, or stretchable nonwoven fabrics (in the case of wet and dry nonwoven fabrics, a stretchable member is inserted when forming the fiber into a sheet. In the case of spunbond, it is obtained by inserting a stretchable member at the time of forming a sheet and integrating it, followed by hot pressing.

The thickness of the base body is limited to a range of 10 to 50 microns, and preferably 10 microns to 40 microns. The reason is that if the thickness of the base body is too thin, the moisture permeability is high. This is because there is no stiffness, and it becomes difficult to apply at the time of application to the skin, and if the thickness of the base body is too thick, sufficient moisture permeability cannot be obtained.
A preferable moisture permeability of the substrate body is 1000 g / m ² · 24 h or more.
The moisture permeability is a value measured according to JIS Z 0208.

  Further, in the present invention, at least 15% or more (preferably 20% or more) of the stretchable member in the thickness direction is limited to being embedded in the base body, and may be 100% embedded. The reason is that if the buried amount is less than 15%, sufficient adhesive strength cannot be obtained, and the substrate main body and the elastic member may cause delamination at the time of peeling from the skin, or the elastic member from the substrate main body. This is because the protrusion of the substrate is large, irregularities are generated on the surface of the base body, and defects in appearance are caused.

  The stretchable member is not particularly limited as long as the yarn is a knitted or woven sheet-like body and stretchable fiber yarn, but the sheet-like body has a predetermined stretchability when the yarn is knitted or woven. If it can be secured, it is not particularly limited, and more preferably, these fibers are preferably warp knitted, weft knitted, and loop knitted in terms of stretchability. A structure such as a pattern, a polygonal pattern, and other stitch patterns may be used.

In this invention, the total thickness of the said sheet-like body means the thickness of the maximum thickness part of the intersection of fibers in the case of three-dimensional structures, such as a grid | lattice form.
The yarn constituting the sheet-like body may be a twisted yarn, a monofilament, a synthetic fiber, or a natural fiber, and the stretchability of the yarn itself is not limited as long as a predetermined stretchability can be secured in a knitted or woven state.
Examples of preferable fibers include synthetic fibers such as cupra, nylon (polyamide), acetate, and polyester, and two or more of these may be mixed.

The thickness of the yarn and the elastic fiber yarn constituting the sheet-like body is preferably 30 denier or less, and more preferably 20 denier or less.
That is, when the thickness of the yarn and the stretchable fiber yarn exceeds 30 denier, it becomes difficult to integrate with the base material body, the stretchability of the base material body is impaired, and suitable adhesion to the skin is obtained. There is a risk of being lost.

Moreover, it is preferable that the base material has a tensile stress of 0.3 kg or less when the base material having a width of 15 mm is stretched by 50%.
That is, if it exceeds 0.3 kg, the adhesion to the skin is poor, there is a sense of incongruity when the skin is applied, and it may cause itching and rash.

  The method for integrating the base body and the stretchable member is not particularly limited. For example, the moisture-permeable resin that becomes the base body is heated and melted, extruded together with the stretchable member, and has a predetermined thickness. A sheet is placed on the elastic member by the method of burying the elastic member when forming the film, or by heat-melting the moisture-permeable resin that becomes the substrate body and extruding it from the pores to form fibers. Well-known things, such as a method of forming a substrate main body, are mentioned.

Although it does not specifically limit as an adhesive which forms the adhesive layer of this invention, For example, conventionally well-known (meth) acrylic acid ester type, silicone type, a natural or synthetic rubber type, urethane type, etc. are selected. The
In the pressure-sensitive adhesive layer, a tackifier, an inorganic filler, an anti-aging agent, an antioxidant, an ultraviolet absorber, a pigment and the like that are added to a general pressure-sensitive adhesive within a range not impairing the effects of the present invention. May be added.

The amount of lamination of the adhesive to the substrate is not particularly limited, the amount of stack is too small enough tackiness becomes difficult to obtain, since if too great breathability may deteriorate, 1 m ² per 15 60 g is preferably laminated.
The method of forming the pressure-sensitive adhesive layer is not particularly limited. For example, a method of directly applying the pressure-sensitive adhesive to one side of the base material, or applying a pressure-sensitive adhesive in advance on a release sheet to form a pressure-sensitive adhesive layer Thereafter, a method of transferring and laminating the obtained pressure-sensitive adhesive layer onto a substrate is exemplified, and the latter method is preferably used.

  As the release sheet, any release sheet conventionally used for adhesive tapes can be used. For example, paper such as kraft paper, kurpack paper, fine paper, polyethylene, polypropylene, polyester, polyurethane And those obtained by applying a release agent such as a long-chain alkyl release agent or a silicone release agent to the surface of the synthetic resin film and the laminated film.

As the method of applying the pressure-sensitive adhesive on the release sheet, any conventionally known method can be applied. For example, when the pressure-sensitive adhesive is a hot-melt type, it is heated and melted with an extruder and is applied onto the release sheet. Extrusion coating method If the pressure sensitive adhesive is solvent type or emulsion type, apply to the release sheet with knife coater, bar coater, etc. and heat dry so that the solid content of the pressure sensitive adhesive is 20-70 g / m ² The method of doing is mentioned.

The pressure-sensitive adhesive laminated on the substrate is usually aged in the case of a two-component cross-linking pressure-sensitive adhesive using a cross-linking agent. For example, the maturation method may be carried out in a heating curing room adjusted to a predetermined temperature. For example, a method of leaving it for a predetermined time and then cooling at room temperature is preferable, and aging at 20 to 80 ° C. for 20 hours or more is preferable.
That is, when the aging temperature is less than 20 ° C., the crosslink density is low and adhesive residue tends to occur. When the aging temperature exceeds 80 ° C., when a white non-woven fabric or woven fabric is used as a substrate, yellowing occurs. Or the adhesive may be deteriorated. On the other hand, when the aging time is less than 20 hours, the crosslink density is low and adhesive residue is likely to occur.

  The medical patch product according to the present invention is a stretchable material selected from the group consisting of a base material body having air permeability or moisture permeability, a sheet-like body in which yarns are knitted or woven, and stretchable fiber yarns as described above. A medical patch product comprising a pressure-sensitive adhesive layer on at least one side of a base material made of an adhesive member, wherein the base body has a thickness in the range of 10 to 50 microns, and at least the total thickness of the stretchable member Since 15% or more is embedded in the base body, it has good adhesion to the skin, high moisture permeability, can prevent stuffiness and itching caused by perspiration for a long time, and has excellent elasticity. It has excellent adhesion to the skin.

  Moreover, if the thickness of the thread | yarn which comprises an elastic member shall be 30 denier or less, it can be set as what was excellent in the adhesiveness to skin more reliably.

  If the tensile stress at the time of 50% elongation of a 15 mm wide base material is 0.3 kg or less, firm adhesion can be secured, and there will be no itching or rash even when applied to the skin for a longer time.

  Hereinafter, the present invention will be described in more detail with reference to examples. In addition, this invention is not limited to a following example.

(Example 1)
Polyol having terminal active hydrogen having a molecular weight of 750 to 5000 A thermoplastic polyurethane resin, which is a base material body composed of a low molecular weight diol having a molecular weight of 500 or less and an organic diisocyanate, is melted, and is formed into a sheet shape so as to have a thickness of 40 microns with a T-die. At the same time, a sheet-like elastic member (Asahi Kasei Cupra, trade name Bemberg x1661) is fed out, laminated with a thermoplastic polyurethane resin, pressed with a press roll, and the total thickness of the elastic member is 100. A base material embedded in a polyurethane resin layer in which% is the base body was obtained.

  Acrylic copolymer having a weight average molecular weight of 500,000 is copolymerized in ethyl acetate with 100 parts by weight of 2-ethylhexyl acrylate and 2.0 parts by weight of 2-hydroxyethyl acrylate having a hydroxyl group as a functional group in an inert gas atmosphere. After the coalescence was obtained, the viscosity was further adjusted using ethyl acetate to obtain an acrylic acid ester copolymer having tg = −18 ° C. and Mn 400,000 (solid content 55%).

100 parts by weight of the obtained acrylic copolymer solution and 1.6 parts by weight of an isocyanate-based crosslinking agent (trade name Coronate L-55E manufactured by Nippon Polyurethane Co., Ltd.) are mixed to form polyurethane on the surface of the fine paper. It is coated on a release sheet that has been laminated and the surface of which has been processed with silicone so as to have a thickness of 40 to 45 microns, and dried in a gear oven at 100 ° C. for 10 minutes to obtain an adhesive layer. Then, the above-mentioned base material is bonded from above the pressure-sensitive adhesive layer so that the elastic member side is in contact with the pressure-sensitive adhesive layer, wound up in a roll shape, and a wound body is obtained. Then, the adhesive tape was obtained by curing at 40 ° C. for 48 hours.
The moisture permeability of the base material was 4000 g / m ² · 24 hr, and the moisture permeability of the adhesive tape after the adhesive coating was 2200 g / m ² .

(Example 2)
Except adjusting the pressure by a press roll and obtaining the base material which 30% of the total thickness of the elastic member was embedded in the polyurethane resin layer which is a base material main body, it was carried out similarly to Example 1. An adhesive tape was obtained.
The moisture permeability of the base material was 4000 g / m ² · 24 hr, and the moisture permeability of the adhesive tape after the adhesive coating was 2200 g / m ² .

(Example 3)
A series of cone-shaped resin (Asahi Kasei Co., Ltd., manufactured by Shin-Etsu Chemical Co., Ltd., trade name MF20) was melted by heat and extruded into a sheet shape with a T-die to a thickness of 40 microns. The product name Bemberg x1661) was rolled out, laminated with a thermoplastic polyurethane resin, pressed with a press roll, and 100% of the total thickness of the elastic member was embedded in the polyurethane resin layer that is the base body An adhesive tape was obtained in the same manner as in Example 1 except that the material was obtained.
The moisture permeability of the substrate was 4800 g / m ² · 24 hr, and the moisture permeability of the adhesive tape after adhesive coating was 2600 g / m ² .

Example 4
Except adjusting the pressure by a press roll and obtaining the base material which 15% of total thickness of the elastic member was embedded in the polyurethane resin layer which is a base material main body, it was carried out similarly to Example 1. An adhesive tape was obtained.
The moisture permeability of the base material was 4000 g / m ² · 24 hr, and the moisture permeability of the adhesive tape after adhesive coating was 1800 g / m ² .

(Comparative Example 1)
An adhesive tape was obtained in the same manner as in Example 2 except that non-stretchable glass fiber was used instead of the stretchable member.
The moisture permeability of the substrate was 4200 g / m ² · 24 hr, and the moisture permeability of the adhesive tape after adhesive coating was 1800 g / m ² .

(Comparative Example 2)
A thermoplastic polyurethane resin similar to that in Example 1 was extruded into a sheet shape to a thickness of 40 microns with a T-die to obtain a base body, and then hot hot having a thickness of 10 microns on one surface of the base body. Adhesive in the same manner as in Example 1 except that a stretchable member similar to that in Example 1 was laminated by dry lamination with a melt adhesive to obtain a substrate in which the stretchable member was not embedded in the substrate body. I got a tape.
The moisture permeability of the substrate was 2200 g / m ² · 24 hr, and the moisture permeability of the adhesive tape after adhesive coating was 800 g / m ² .

The moisture permeability of the base material and the adhesive tape obtained in Examples 1 to 4 and Comparative Examples 1 and 2, adhesive strength of the adhesive tape to SUS, self-rear surface adhesive force, lifting, skin surface stuffiness, and adhesiveness were examined. The results were comprehensively evaluated for stretchability and permeability, and the results are shown in Table 1.
In addition, the measuring method or evaluation method of moisture permeability, SUS adhesive strength, self-back surface adhesive strength, peeling off, and skin surface moisture is as follows.
(1) Moisture permeability The moisture permeability was measured according to JIS Z0208 (cup method).
(2) Adhesive force to SUS A test piece having a width of 20 mm and a length of 150 mm was prepared from the above-mentioned adhesive tape so that the length direction of the test piece and the application direction of the pressure-sensitive adhesive coincided with each other. After the stainless steel plate was thoroughly washed with alcohol, an adhesive tape was attached to the stainless steel plate where the alcohol was sufficiently dried, and the adhesive strength after 30 seconds was measured by 1 reciprocating pressure with a 1 kg roller to obtain the adhesive strength against stainless steel.
The measuring machines and test conditions used for measuring the adhesive strength are as follows.
Test device Tensile tester with load cell (strograph)
・ Tensile speed 300mm / min
・ Tensile angle 180 °, number of samples 3 each
Measurement was performed in an environment of 23 ° C. and 65% RH (constant temperature and humidity).
(3) Self-Back Adhesive Force A test piece having a width of 20 mm and a length of 150 mm was prepared from the pressure-sensitive adhesive tape so that the length direction of the test piece and the application direction of the pressure-sensitive adhesive coincided with each other. After thoroughly washing the stainless steel plate with alcohol, affix the adhesive tape to the stainless steel plate where the alcohol is sufficiently dried, and then apply a test piece on top of it. The adhesive strength when the test piece was peeled was measured and used as the self-rear surface adhesive strength.
The measuring machines and test conditions used for measuring the adhesive strength are as follows.
Test device Tensile tester with load cell (strograph)
・ Tensile speed 300mm / min
・ Tensile angle 180 °, number of samples 3 each
Measurement was performed in an environment of 23 ° C. and 65% RH (constant temperature and humidity).
(4) Floating off A test piece cut to 20 mm x 80 mm from the above adhesive tape is affixed to the back of 10 randomly selected monitors, and the adhesion state of the test piece to the skin after 12 hours is visually confirmed to lift off. I examined the number of people.
(5) Steaming on the skin The test piece cut to 20mm x 80mm from the above adhesive tape is affixed to the back of 10 randomly selected monitors, and the moisture content on the skin when peeled off after 12 hours is measured with a portable moisture meter. Measured. In addition, when the test piece peeled off from the skin within 12 hours, the moisture content on the skin surface immediately after peeling off was recorded.

(6) Overall evaluation (a) Adhesiveness
◎ When 10 monitors are wrapped around fingers for 24 hours and slightly lifted at the end after 24 hours, 0 out of 10 ◎, less than 3 out of 10 ○ The case of 4 or more out of 10 people was evaluated as x.
(B) Elasticity
Investigate the tense feeling when 10 monitors are wrapped around your fingers. ◎ if 10 out of 10 people feel the sense of tension, ○ if less than 3 out of 10 and 4 out of 10 The case of more than people was evaluated as x.
(C) Moisture permeability
After 10 monitors are wrapped around a finger for 24 hours and then peeled off, the peeled-off part is 0 out of 10 ◎, 3 or 10 out of 10 ○, the case of 4 or more out of 10 was evaluated as x.

Claims (3)

A pressure-sensitive adhesive layer on at least one surface of a base material comprising a base material body having air permeability or moisture permeability, and a stretchable member selected from the group consisting of a knitted or woven sheet-like body and stretchable fiber yarns A medical patch product comprising:
A medical patch product, wherein the thickness of the base body is in the range of 10 to 50 microns, and at least 15% of the total thickness of the stretchable member is buried in the base body.   The medical patch product according to claim 1, wherein the thickness of the thread constituting the stretchable member is 30 denier or less.   The medical patch product according to claim 1 or 2, wherein a tensile stress at 50% elongation of a 15 mm-wide substrate is 0.3 kg or less.