JP2008184436A - Hyperesthesia-suppressing dental abrasive material composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an abrasive material suppressing hyperesthesia caused when polishing teeth, concurrently enabling effective cleaning of the tooth surface, and excellent in operability. <P>SOLUTION: The hyperesthesia-suppressing dental abrasive material composition comprises (A) an acidic group-containing (co)polymer obtained by (co)polymerizing at least one radically polymerizable monomer selected from the group consisting of a radically polymerizable monomer having an acidic group in a molecule, a radically polymerizable monomer having a functional group in a molecule which functional group is easily converted to an acidic group in water, and a salt thereof, (B) an inorganic calcium salt and (C) water. Thereby, high tooth abrasive performance and high operability are possessed and hyperesthesia caused in tooth polishing is suppressed. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a dental abrasive composition capable of suppressing hypersensitivity.

  In recent years, interest in prevention of dental diseases is very high, and tooth surface abrasives are frequently used for professional mechanical cleaning by dental care workers such as calculus removal. Furthermore, similar tooth surface abrasives are used after tooth bleaching or mechanical removal (root planing) of tooth root surface contaminated tooth for those suffering from periodontal disease. However, the abrasives used in these procedures often cause hypersensitivity, especially dentin hypersensitivity, and many patients complain of pain during tooth surface polishing.

  In addition, there is a growing interest in aesthetics of teeth, and tooth bleaching is frequently performed, but in many cases, tooth bleaching involves fine demineralization of the outermost surface layer of the tooth, A system that removes and removes color components is used. In addition, many tooth bleaching agents used for tooth bleaching as described above require surface polishing after bleaching treatment, but in addition to tooth demineralization by bleaching treatment, by performing polishing, pain is caused. The possibility of appealing becomes even higher.

  At present, a large number of abrasive materials for teeth are commercially available. As represented by, for example, Patent Document 1, these materials can improve the physical polishing strength of the abrasive material, the cleaning performance in a minute portion, or the operability. There is an improvement in the point of improvement, and an abrasive that makes it difficult to generate hypersensitivity is not commercially available.

  On the other hand, regarding suppression of hypersensitivity, Patent Document 2 discloses an anti-dentin hypersensitivity that reduces hypersensitivity by using an aqueous emulsion that reacts with a calcium compound and forms an aggregate larger than the diameter of the dentinal tubule. Although a composition has been proposed, this Patent Document 2 does not mention treatment during tooth surface cleaning.

Further, in Patent Document 3, a cleaning material useful in suppressing dentin hypersensitivity with a composition similar to Patent Document 2 has been proposed, but the operation step is likely to be complicated, and the operator Both patients are disadvantaged.
JP 2003-40754 A JP-A-8-225424 JP-A-7-82125

  An object of the present invention is to provide a polishing material that suppresses hypersensitivity induced during tooth polishing, enables effective cleaning of a tooth surface, and has good operability.

The hypersensitive hypersensitivity dental abrasive composition of the present invention,
(A) selected from the group consisting of a radical polymerizable monomer having an acidic group in the molecule, a radical polymerizable monomer having a functional group easily converted into an acidic group in water in the molecule, and salts thereof. An acidic group-containing (co) polymer formed by (co) polymerizing at least one radical polymerizable monomer,
(B) inorganic calcium salt,
(C) water,
It is characterized by containing.

  The perceptual hypersensitivity dental abrasive composition of the present invention can remarkably suppress the hypersensitivity induced during tooth polishing while maintaining high tooth polishing performance and high operability.

Hereinafter, the hypersensitivity-suppressing dental abrasive composition of the present invention will be specifically described.
In the present invention, “part” or “%” indicates a weight basis unless otherwise specified. In addition, “(meth) acryl ...” is described as a generic term for “acrylic ...” and “metaacryl ...”.

  The acidic group-containing (co) polymer (A) component constituting the hypersensitivity-suppressing dental abrasive composition of the present invention has the effect of blocking the dentinal tubules of the dentine and suppressing hypersensitivity and polishing operation. Functions as a lubricant or thickener.

  The acidic group-containing (co) polymer (A) component used in the present invention has a radical polymerizable monomer having an acidic group in the molecule and a functional group that can be easily converted into an acidic group in water in the molecule. An acidic group-containing (co) polymer obtained by (co) polymerizing at least one radical polymerizable monomer selected from the group consisting of a radical polymerizable monomer and a salt thereof.

That is, the acidic group-containing (co) polymer (A) component used in the present invention includes a radical polymerizable monomer (Ms) having an acidic group in the molecule, a functional group that can be easily converted into an acidic group in water. It is a radical polymerizable monomer (Ms) having at least one group or a salt thereof (Ms). These can be used alone or in combination.

  The acidic group-containing (co) polymer (A) component used in the present invention is a polymer obtained by polymerizing the above radical polymerizable monomer or a salt thereof alone, or a copolymer obtained by copolymerizing these in combination. Although it is a polymer, it may be a copolymer obtained by copolymerizing a monomer (M1) other than these radical polymerizable monomers (Ms).

  Furthermore, the main chain of the acidic group-containing (co) polymer (A) component preferably has a radical polymer structure, but for example, a short crosslinked structure having a molecular chain length of 15 atoms or less may be formed. Further, the pendant may have a dehydration condensation molecular chain.

  Examples of the acidic group contained in the radical polymerizable monomer (Ms) or the functional group that can be easily converted into an acidic group in water include a carboxylic acid group, a phosphoric acid group and a sulfonic acid group, or easily in water. Mention may be made of substituents which are converted into these functional groups. In the present invention, among these, a sulfonic acid group and / or a functional group that easily converts to a sulfonic acid group in water is preferable.

Examples of the radical polymerizable monomer (Ms) used in the present invention include 2-sulfoethyl (meth) acrylate, 1-sulfo-1-propyl (meth) acrylate, and 1-sulfo-2-propyl (meth) acrylate. 2-sulfo-1-propyl (meth) acrylate, 2-sulfo-2-propyl (meth) acrylate, 1-sulfo-2-butyl (meth) acrylate, 3-sulfo-2-butyl (meth) acrylate, 1 -Sulfoalkyl (meth) acrylates such as methyl-2-sulfopropyl (meth) acrylate and 2-methyl-2-sulfopropyl (meth) acrylate;
At least a part of hydrogen atoms constituting the alkyl chain such as 3-bromo-2-sulfo-2-propyl (meth) acrylate and 3-methoxy-1-sulfo-2-propyl (meth) acrylate are halogen atoms. Substituted compounds, compounds having heteroatoms such as oxygen in the alkyl chain;
Compounds such as 1,1-dimethyl-2-sulfoethyl (meth) acrylamide, 2- (meth) acrylamide-2-methylpropanesulfonic acid, and the like;
Furthermore, vinyl aryl sulfonic acid, such as 4-styrene sulfonic acid and 4- (prop-1-en-2-yl) benzene sulfonic acid, etc. can be mentioned.

Of these, 2- (meth) acrylamide-2-methylpropanesulfonic acid, 4-styrenesulfonic acid and / or a salt thereof are preferably used in the present invention.
Further, as the radically polymerizable monomer that can be most widely used as a monomer (M1) component other than the radically polymerizable monomer (Ms) used in the present invention, for example, a conjugated diene unit such as butadiene or isoprene is used. Mers;
Aromatic vinyl monomers such as styrene, α-methylstyrene, chlorostyrene;
Vinyl cyanide monomers such as acrylonitrile and methacrylonitrile;
Alkyl (meth) acrylates such as methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate;
Hydroxyalkyl (meth) acrylates such as 2-hydroxyethyl (meth) acrylate, 3-hydroxypropyl (meth) acrylate, 2,3-dihydroxypropyl (meth) acrylate;
Like N- (meth) acryloyloxyethyl-acetamide, N- (meth) acryloxypropyl-acetamide, N- (meth) acryloxyisopropyl-acetamide, N- (meth) acryloxybutyl-acetamide A compound in which (meth) acrylate is (meth) acrylamide;
Vinyl halides and vinylidenes such as vinyl chloride, vinyl bromide, vinylidene chloride, vinylidene bromide;
Examples thereof include vinyl esters such as vinyl acetate and vinyl propionate. These monomers can be used alone or in combination.

  Furthermore, as long as the performance of the present invention is not impaired, the monomer constituting the polymer (A) obtained by (co) polymerizing a radically polymerizable monomer as a monomer component, the radically polymerizable monomer having antibacterial properties The body (M2) can be used. By using the radically polymerizable monomer (M2) having antibacterial properties to impart antibacterial properties to the acidic group-containing (co) polymer (A) component, it can prevent dental diseases such as caries over a long period of time. I can expect.

  Examples of such radically polymerizable monomers (M2) having antibacterial properties include 12- (meth) acryloyloxidedecylpyridinium bromide, benzylbis [(meth) acryloyloxyethyl] dodecylammonium chloride, N, N, N-tris. Examples include [(meth) acryloyloxyethyl] dodecyl ammonium chloride, a compound obtained by adding ether of 10-undecenyl alcohol to polyethylene glycol mono (meth) acrylate.

  The monomer having an acidic group or a functional group that can be easily converted into the functional group in water is usually 0.00001 to 0.01 mol / g in the acidic group-containing polymer (A) component. (Co) polymerization is preferably carried out in an amount of 0.00002 to 0.005 mol / g.

  In the present invention, the acidic group-containing (co) polymer (A) component is preferably an aqueous emulsion (Ae) or a water-soluble polymer (Aw). It is preferable that the solubility with respect to the water of the acidic group containing (co) polymer (A) component in 25 degreeC is 25% or more.

  When the acidic group-containing (co) polymer (A) component is an aqueous emulsion (Ae), in order to infiltrate the aqueous emulsion to a depth sufficient to seal the dentin tubule, the aqueous emulsion (Ae) The particle size of the component is preferably smaller than the diameter of the dentin tubule. In general, the diameter of the dentinal tubule varies depending on the position or depth, and although there are individual differences, it is usually in the range of 1 to 3 μm. Accordingly, the average particle size of the component particles constituting the aqueous emulsion (Ae) is preferably 3 μm or less, more preferably 1 μm or less.

  The diameter of the dentinal tubule is determined by removing the enamel from the extracted tooth, brushing the exposed dentin surface with a dentifrice and a toothbrush for 1 minute or more, then performing ultrasonic cleaning in water, scanning type It can measure by observing with an electron microscope (SEM).

  Further, since there is a distribution in the particle size of the component constituting the aqueous emulsion (Ae), it is not particularly required that the particle size of all the emulsion particles is smaller than the dentinal tubule diameter. In the present invention, among the particles forming the emulsion of the aqueous emulsion (Ae) component, those having a particle size of less than 3 μm preferably account for 50% or more, and the particle size of 90% or more of the emulsion particles is less than 3 μm. More preferred. In addition to the above conditions, among the particles forming the aqueous emulsion used as the polymer (A) component having a radical polymerizable monomer as a single unit, those having a particle size of 1 μm or less occupy 65% or more. Is particularly preferable, and it is particularly preferable to occupy 75% or more. When the emulsion particles have a particle size distribution as described above, pain due to hypersensitivity is reduced.

  As a more preferred aqueous emulsion (Ae) component, for example, polymer emulsion particles are preferably dispersed in a high-speed mixer or homogenizer, for example, with a diameter of 3 μm or less, more preferably with a diameter of 1 μm or less, and most preferably with a diameter of 0.00. It is desirable to improve the dispersion stability by preparing emulsion particles having a size of 5 μm or less so that the emulsion particles are present in an amount of 0.5% or more in the acidic group-containing (co) polymer (A) component. Further, in the acidic group-containing (co) polymer (A) component, it is preferable that emulsion particles having a particle size of 1.0 μm or less occupy 50% or more, particularly 75% or more of the whole emulsion particles, and emulsion particles Most preferably.

  The component for forming an aqueous emulsion (Ae) having a particle size smaller than the dentin tubule size contained in the acidic group-containing (co) polymer (A) component is highly water-soluble and usually has a solubility in water of 25 ° C. When a calcium compound, such as calcium chloride, is added to the acidic group-containing (co) polymer (A), the compound reacts with the calcium compound and has a diameter larger than the dentinal tubule diameter. The aggregate which has can be formed.

The diameter of the aggregate formed in this manner usually exceeds 3 μm, preferably 10 μm or more, more preferably 50 to several thousand μm.
The addition amount of the calcium compound is preferably in the range of 10 to 100 parts by weight with respect to 100 parts by weight of the emulsion particles or nonvolatile components in the emulsion.

There is no restriction | limiting in particular in the manufacturing method of an acidic group containing (co) polymer (A), It can manufacture by a conventionally well-known method.
As a specific production method, when the acidic group-containing (co) polymer (A) is an aqueous emulsion (Ae), it can be produced by employing a conventionally known emulsion polymerization method. Specifically, in the presence of a polymerization initiator, various monomers can be added all at once, divided, or continuously dropwise into an aqueous medium. The polymerization temperature at this time is generally 0 to 100 ° C., and practically 30 to 90 ° C.

  Moreover, when an acidic group containing (co) polymer (A) component is a water-soluble polymer (Aw), it can manufacture by a conventionally well-known method using water or an aqueous medium. For example, after charging various monomers and a polymerization initiator in water or an organic solvent and allowing the polymerization reaction to proceed by raising the temperature, for example, a method of obtaining an aqueous polymer by reprecipitation purification or the like can be mentioned. In this case, the reaction temperature is generally 40 to 200 ° C.

  The number average molecular weight (Mn) of the acidic group-containing (co) polymer (A) component measured by the GPC method is preferably 3,000 or more, more preferably 7,000 or more, and even more preferably 10,000. That's it. The upper limit of the number average molecular weight is usually 5 million.

The aqueous polymer (Aw) having a preferable water solubility as the acidic group-containing (co) polymer (A) component has (meth) acrylamide alkanesulfonic acid (H ₂ C═C) in the polymer molecule.
Component units derived from radically polymerizable monomers (Ms) such as (R ¹ ) —CO—NH—R ² —SO ₃ H, R ¹ : H or CH ₃ , R ² : a divalent hydrocarbon group) It is a polymer having Furthermore, in the polymer molecule, a (poly) hydroxyalkyl having 4 to 8 carbon atoms having one or more hydroxyl groups (
Derived from (meth) acrylamide (H ₂ C═C (R ³ ) —CO—NH—R ⁴ (OH) _n , R ³ : H or CH ₃ , R ⁴ : hydrocarbon group, n: an integer of 1 or more) The component units to be used are in a hydroxyl group molar ratio (total number of hydroxyl groups of the unit in the polymer / number of moles of total monomer units), preferably 0.7 to 11.0 [mol / mol], more preferably 0. It is preferable to use a polymer having a molecular weight of .75 to 10.5 [mol / mol], more preferably 0.8 to 10.0 [mol / mol].

Copolymers other than the copolymer (hereinbelow referred to as AS-HA polymer) having the (meth) acrylamide alkanesulfonic acid unit and the (poly) hydroxyalkyl (meth) acrylamide unit (herein, the following) AS-HA equivalent polymer), AS-
The numerical range of the molar weight ratio [mol / g], which is the ratio of the number of moles of acidic groups (sulfonic acid, etc.) and hydroxyl groups contained in the AS-HA equivalent polymer to the weight of the HA equivalent polymer is AS-HA polymer. The molar weight ratio corresponding to the numerical range of the molar ratio [mol / mol] in the case (wherein the AS-HA polymer is 2,3-dihydroxypropyl (meth) acrylamide and 2- (meth) acrylamide-2) It is preferable that the ratio is calculated as a copolymer comprising methylpropanesulfonic acid and having methyl acrylate if necessary.

  In the present invention, a styrene sulfonic acid unit is preferred as the (Ms) component unit that forms the polymer (Ae) having a preferred aqueous emulsion form as the acidic group-containing (co) polymer (A) component. Furthermore, in the polymer molecule, the (meth) acrylic acid alkyl ester unit having 4 to 8 carbon atoms is preferably in a molar ratio (number of moles of the unit / number of moles of total polymerized units in the polymer). To 99.9 [mol / mol], more preferably 80 to 99.9 [mol / mol], and still more preferably 85 to 99.5 [mol / mol]. .

  The acidic group-containing (co) polymer (A) component in the present invention is usually in the range of 1 to 25%, preferably 3 to 22%, more preferably 5 to 20% in the total amount of the composition. Contained in an amount. If the upper limit of this numerical range is exceeded, the viscosity of the composition will rise, making it difficult to carry out polishing and cleaning operations smoothly.If the lower limit is exceeded, the viscosity of the composition will be extremely low, and during the cleaning operation “Sagging” or scattering to other parts is likely to occur, and further, the sealing performance of the dentinal tubules is reduced, and the effect of suppressing hypersensitivity is hardly exhibited.

Further, the radical polymerizable monomer (Ms) having an acidic group is included in the total amount of the component units constituting the polymer (A) obtained by (co) polymerizing the radical polymerizable monomer as a monomer component. The content is preferably 0.1 to 30 mol%, more preferably 0.1 to 20 mol%, and still more preferably 0.5 to 10 mol%. If it falls below this range, the perceptual hypersensitivity suppressing effect becomes difficult to be expressed, and if it exceeds, there is a concern about aggregation with the inorganic calcium salt (B) component to be blended.

  The inorganic calcium salt (B) in the dental abrasive composition having a hypersensitivity suppressing property of the present invention is a calcium salt whose solubility in water at 25 ° C. is usually less than 0.5 g / 100 ml. It is. The inorganic calcium salt has a function of removing organic substances and inorganic deposition components on the tooth surface.

Specific compounds include CaHPO ₄ (hereinafter referred to as DCP), Ca ₃ (PO ₄ ) ₂ (hereinafter referred to as TCP), Ca ₅ (PO ₄ ) ₃ OH, and Ca ₄ O (PO ₄ ) _2. (Hereinafter referred to as TTCP), Ca ₈ H ₂ (PO ₄ ) ₆ , Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ (hereinafter referred to as HAP), CaP ₄ O ₁₁ , Ca (PO ₃ ) ₂ , Ca ₂ P ₂ O ₇ , Ca (H ₂ PO ₄ ) ₂ , CaO, Ca (
OH) ₂ , CaCO ₃ and their hydrates. These can be used alone or in combination. There are no particular limitations on the crystal structure of these inorganic calcium salts, and non-stoichiometric defects may be included. Of these, DCP, TCP, TTCP, and HAP are preferably used in the present invention. These inorganic calcium salts can be used alone or in combination.

  Of these inorganic calcium salts, when DCP or TTCP is used, it is preferable to use both. By using both at the same time, after applying the dental abrasive composition having the sensitivity to hypersensitivity, these phosphates bind to the tooth surface in the presence of moisture in the oral cavity and are similar to hard tissues It can be converted into HAP and the tooth surface can be modified.

  The usage-amount of an inorganic calcium salt (B) component is 0.1 to 50% normally with respect to the whole quantity of a composition, Preferably it is 1 to 40%, More preferably, it is 3 to 30%. If the upper limit of this numerical range is exceeded, the viscosity of the composition will increase and cleaning operations will not be possible, and it will be difficult for the composition to penetrate the tooth surface or interdental area, resulting in poor cleaning performance and excessive tooth surface. In addition, if it falls below the lower limit, the desired cleaning effect is hardly exhibited.

  Further, in the present invention, when DCP and TTCP are used at the same time, the mixing weight ratio (TTCP / DCP) of the both is usually 0.33 to 3.5, preferably 2.3 within the range of the amount used. Is in the range of ~ 3, particularly preferably 2.6 to 2.8. Beyond this range, the conversion to hydroxyapatite may not be sufficient.

  In the present invention, the shape of the inorganic calcium salt (B) component is not particularly limited, and may be spherical, spindle-shaped or irregular, but in order to polish and clean the tooth surface in a short time, it is irregular. Preferably there is. In order to further improve the cleaning performance, it is preferable to include a sintered body having high hardness.

The longest diameter of the inorganic calcium salt (B) component used here is usually 0.001 to 300 μm, preferably 0.05 to 250 μm, and more preferably 0.01 to 200 μm. Here, the longest diameter means the diameter of the maximum length of the particle including the case where the particle shape of the inorganic calcium salt (B) component is spherical. If the upper limit of this numerical range is exceeded, the dental hard tissue may be excessively ground, and if the lower limit is exceeded, the polishing performance will be extremely low, and polishing will take a long time. There are concerns about adverse effects. Furthermore, when DCP and TTCP are used simultaneously, the longest diameter of DCP is usually in the range of 0.001 to 30 μm, preferably 0.05 to 20 μm, more preferably 0.1 to 15 μm.
The longest diameter is usually 0.5 to 30 μm, preferably 1 to 25 μm, more preferably 10 to 20 μm. If the value is below the lower limit of the numerical range, the composition tends to aggregate during the polishing operation and the operation becomes difficult. If the value exceeds the upper limit, it takes a long time to convert the tooth surface to HAP, and the tooth surface is modified. Quality effects are less likely to appear.

  Further, there is no particular limitation on the presence form of these calcium phosphate salts, and both may be particles that are mixed and molded in an amount within the above-mentioned blending range, or the entire blending The respective particles may be mixed so that the ratio is substantially within the above range, or particles having different blending ratios may be mixed so as to be within the above range.

  The component (C) constituting the hypersensitive hypersensitive dental abrasive composition of the present invention is water. While reducing the heat generation during polishing, the composition is made into a paste useful for polishing. The type of water is not particularly limited as long as safety to the living body is ensured, but it is preferable to use distilled water, deionized distilled water, or Japanese Pharmacopoeia purified water.

  When the acidic group-containing (co) polymer (A) component is an aqueous emulsion, the water as component (C) in the present invention is also contained in the inorganic calcium salt (B) component. Crystal water is also counted as the water of component (C) and totaled. In the perceptual hypersensitivity dental abrasive composition of the present invention, the amount of water as component (C) is usually 99 to 25%, preferably 96 to 38%, more preferably relative to the total amount of the composition. 92-50%. When the upper limit of this numerical range is exceeded, the viscosity of the composition decreases, and “sagging” to other parts during the cleaning operation or scattering to the surgeon is likely to occur. Not only does the cleaning performance become significantly lower, but the generation of heat during the cleaning operation may adversely affect the pulp or periodontal tissue.

  However, a composition corresponding to an embodiment in which the composition of the present invention is prepared in advance to be less than the preferred moisture content as described above, and water is added during treatment to return to the preferred moisture content. A composition having is also suitable. In that case, it is preferably 55 to 3%, more preferably 52 to 5%, still more preferably 50 to 10%. If the value falls below the lower limit of the numerical range, it may take time to reconstitute a uniform composition, leading to a decrease in workability. If the value exceeds the upper limit, the degree of freedom of water content adjustment is reduced. Alternatively, it may be substituted by a small amount of alcohols (ethanol etc.) or ketones (acetone etc.) instead of water at a ratio in this numerical range.

  The perceptual hypersensitivity dental abrasive composition of the present invention is a composition containing an acidic group-containing (co) polymer (A), an inorganic calcium salt (B) and water (C) as described above. Further, other components may be contained.

Component (D) is an acidic compound and can be added for the purpose of promoting the interaction between the polymer (A) and the tooth, imparting stability to the film, and further imparting storage stability of the composition. . The component (D) may be either an inorganic acid or an organic acid, and is not particularly limited. However, the acidic compound that is not very strong and has a low decalcifying action on the tooth is preferably used in dentistry. Further, a water-soluble acid having a significantly lower molecular weight than (A), for example, a molecular weight of 200 or less and / or a salt thereof is preferable, and the calcium salt of the acid is insoluble or hardly soluble in water. Here, the salt is a metal salt, an ammonium salt, or an amine salt. As a measure of water solubility, the solubility in water at 25 ° C. is 0.5 g / 100 g or more. Specifically, in addition to oxalic acid, citric acid, tartaric acid, propionic acid, and / or their salts, alkali metal salts and ammonium salts of sulfuric acid such as ammonium sulfate, ammonium hydrogen sulfate, sodium ammonium sulfate, potassium ammonium sulfate, sodium sulfite, Alkali metal salts and ammonium salts of sulfite such as ammonium sulfite can be preferably used. Moreover, as (D) component, what does not have radically polymerizable ethylenic double bond is used suitably.

  The blending amount is preferably in the range of 0.01 to 10 (more preferably 0.02 to 5)% in the total amount of the composition. If the lower limit of this numerical range is not reached, the effect of acid addition cannot be confirmed, and if the upper limit is exceeded, the surface may be inadvertently decalcified not only for the application part but also for the surrounding teeth. is there.

  (E) component which is another component mix | blended with the hypersensitivity suppression dental abrasive | polishing material composition of this invention is a fluorine compound. By adding a fluorine compound to the perceptual hypersensitivity dental abrasive composition of the present invention, the acid resistance of the tooth itself can be improved. The fluorine compound (E) that can be used in the present invention is capable of releasing fluorine ions into water. Examples of such fluorine compounds (E) include disodium fluorophosphate, tin fluoride, sodium fluoride, calcium fluoride, potassium fluoride, sodium silicon fluoride, fluoroaluminosilicate glass, ammonium fluoride, fluorine. Calcium fluoride, sodium monofluorophosphate, stannous fluoride and the like can be mentioned. Among these, it is preferable to use sodium fluoride, calcium fluoride, sodium monofluorophosphate, and stannous fluoride as the fluorine compound (E). These fluorine compounds (E) can be used alone or in combination. The compounding amount of the fluorine compound in the composition of the present invention is such that the amount and application frequency of the hypersensitivity-suppressing dental abrasive composition of the present invention, the acid resistance or the effectiveness of remineralization, and further to the human body. Can be set as appropriate in consideration of the influence of the above.

  From this viewpoint, the fluorine compound (E) in the present invention has a fluorine ion concentration in the composition of usually 0.0001 to 5%, more preferably 0.001 to 2%, and still more preferably 0.01 to 1%. Used in amounts that are within range. Below this numerical range, the acid resistance improving action or remineralization action of the desired tooth substance may not be sufficiently exhibited, and it is difficult to confirm the action by adding the fluorine compound (E). If the amount exceeds 100%, there is a concern about harm to the living body.

  Furthermore, the hypersensitivity-suppressing dental abrasive composition of the present invention includes hydrogen peroxide as a component (F) in order to assist in improving the color tone of the tooth surface within the range in which the properties of the composition are not impaired. Alternatively, urea peroxide may be added. These hydrogen peroxide and urea peroxide can be blended alone or in combination. In the composition of the present invention, the hydrogen peroxide or urea peroxide (F) is usually 0.1 to 5%, preferably 0.5 to 4%, more preferably, based on the total amount of the composition. It can mix | blend in the quantity within the range of 1-3%. By blending hydrogen peroxide or urea peroxide (F) in such an amount, the abrasiveness is improved without excessively decalcifying the tooth surface.

  Further, the perceptual hypersensitivity dental abrasive composition of the present invention assists in improving the color tone of the tooth surface and provides antibacterial properties on the tooth surface as long as the properties of the composition are not impaired. For the purpose, a titanium compound can be further blended as the component (G). Examples of titanium compounds that can be used in the present invention include titanium dioxide.

There are various crystal forms of titanium dioxide which is a suitable example of the titanium compound (G) that can be blended in the composition of the present invention. In the present invention, it is preferable to blend anatase type titanium oxide. Such titanium dioxide preferably has photocatalytic activity, and is not limited to a shape and a property as long as it has photocatalytic properties. In addition, platinum-supported titanium dioxide in which platinum is supported on such titanium dioxide to improve the photocatalytic activity can also be used. It is also possible to use titanium dioxide having improved photocatalytic action in response to light in the visible light region by performing plasma treatment or the like on titanium dioxide. The titanium dioxide may be in a powder state or in a sol state dispersed in a medium such as water. The average particle diameter of the primary particles of titanium dioxide that can be used in the present invention is usually 1 to 500 nm, preferably 5 to 5 nm.
It is in the range of 200 nm. The titanium dioxide having the average particle diameter as described above may be a primary particle or an aggregate in which primary particles are aggregated. When titanium dioxide aggregates are used, the particle size of the aggregates is usually in the range of 5 nm to 50 μm, preferably in the range of 10 nm to 30 μm. When the titanium compound (G) is blended in the present invention, the titanium compound (G) is most preferably anatase type (g1), and the average particle size of primary particles satisfies the condition of 1 to 500 nm (g2). Titanium dioxide particles. This means that each particle satisfies (g1) and (g2) simultaneously. Compared with this, (g1) and non- (g2) particles and non- (g1) and (g2) particles In the case of this mixture, the effect is not expected.

  In the present invention, the titanium compound (G) is preferably 0.01 to 24%, more preferably 0.1 to 12%, still more preferably 0.1 to 8% with respect to the total amount of the composition. Can be blended. Below this numerical range, the effect of improving the desired tooth color cannot be exhibited, and when this numerical range is exceeded, the acidic group-containing (co) polymer (A) component or acidic compound (D) component is stored during storage. It reacts and causes significant agglomeration, and there is a risk of excessively polishing the teeth.

  It is preferable to add a binder as the component (H) to the hypersensitive hypersensitive dental abrasive composition of the present invention. This binder (H) imparts an appropriate viscosity to the composition of the present invention to prevent “sag” and “scattering” when the composition is used, and the composition of the present invention is applied to the dentinal tubule. It is used to improve the suppression effect of hypersensitivity by infiltrating to the extent and sealing the dentinal tubule.

The binder (H) that can be used in the present invention is a compound that can impart a degree of viscosity or consistency to the composition. Examples of such a binder (H) include water-soluble polymers such as polyvinyl pyrrolidone, polyethylene glycol, polypropylene glycol and polyvinyl alcohol (PVA); natural polymer compounds such as gum arabic, alginic acid and carrageenan; carboxymethyl cellulose (CMC) ) And the like. These binders can be used alone or in combination.

  The perceptual hypersensitivity dental abrasive composition of the present invention contains an acidic group-containing (co) polymer (A), an inorganic calcium salt (B) and water (C) as essential components. By jointly expressing a predetermined viscosity, the composition of the present invention makes it difficult for “sag” and “scattering” to occur, and the composition penetrates into the dentinal tubule and seals the dentinal tubule, thereby deepening the deep part of the tooth. In this way, the abrasive composition is prevented from penetrating and the hypersensitivity is suppressed. The viscosity of the composition of the present invention can be adjusted mainly by the blending ratio of the acidic group-containing (co) polymer (A), inorganic calcium salt (B) and water (C). The viscosity of the composition can be adjusted by blending the binder (H).

The composition of the present invention usually has a viscosity at the use temperature (36 ° C.) of the composition of the present invention in order to prevent “sag” and “scattering” and to make the dentinal tubule blockage rate 99% or more, for example. Is 0.1
It adjusts in the range of -500 Pa.s, Preferably it is 5-350 Pa.s, More preferably, it is 8-250 Pa.s. In order to adjust the composition of the present invention to such a viscosity, for example, when polyvinyl alcohol (PVA) is used as the binder (H), polyvinyl alcohol (PVA) is usually added to the composition of the present invention. Is an amount in the range of 0.5 to 35%, preferably 1 to 3%.
Blend in an amount in the range of 0%. The binder (H) is blended in such an amount so that the viscosity of the composition of the present invention is usually 0.1 to 500 Pa · s, preferably 5 to 350 Pa · s, more preferably 8 to
By adjusting within the range of 250 Pa · s, the suppressive action against hypersensitivity becomes very high, and it is very easy to use without causing “sag” or “scattering” at the time of use.

An aqueous medium can be further added to the composition of the present invention as component (I). Examples of such an aqueous medium (I) include glycols such as propylene glycol, ethylene glycol, diethylene glycol, triethylene glycol and propylene glycol, and alcohols such as glycerol, sorbitol and ethanol. it can. These aqueous media (I) can be used alone or in combination. In the case of using the aqueous medium (I) in the present invention, it is preferable to use ethanol having low harmfulness. The amount of the aqueous medium (I) used is such that the viscosity of the composition is usually 0 as described above. .
It is adjusted to be in the range of 1 to 500 Pa · s, preferably 5 to 350 Pa · s, more preferably 8 to 250 Pa · s.

Furthermore, in the perceptual hypersensitivity dental abrasive composition of the present invention, as a component (J) as long as the properties of the composition of the present invention are not impaired,
Thickeners such as silica and talc;
Foaming agents such as sodium lauryl sulfate and sodium laurate;
Sweeteners such as xylitol, sorbitol, aspartame, sucralose, stevia;
Perfumes such as sorbitol, l-menthol, limonene;
Inorganic pigments such as titanium mica, titanium oxide, bismuth oxychloride, synthetic phlogopite, mica, iron oxide;
Colors such as Blue No. 1, Blue No. 404, Red No. 106, Red No. 201, Red No. 220, Red No. 225, Red No. 226, Red No. 227, Yellow No. 4, Gunjo, Conger, etc .;
Bactericidal / antibacterial agents such as chlorhexidine hydrochloride, cetylpyridinium chloride, chlorhexidine gluconate, dipotassium glycyrrhizinate, isopropylmethylphenol, triclosan, benzethonium chloride;
Vitamins such as retinols, riboflavin, ascorbic acid, cholecalciferols, nicotinic acids;
Alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and salts or hydroxides thereof In addition, amino acids such as tranexamic acid and taurine or analogs thereof may be added.

  The hypersensitivity-suppressing dental abrasive composition of the present invention is composed of the above components, and the components constituting the composition may be mixed in the composition from the beginning, The composition of the present invention may be prepared on the spot by packaging at least a part of the components constituting the composition as separate bodies and mixing these components as necessary. That is, the present invention also includes a perceptual hypersensitivity dental abrasive composition that is mixed and used at the ratio by weight when used.

  In consideration of convenience during use, a mixture in which the respective components are mixed in advance is preferable. Surprisingly, the inorganic calcium salt (B) having a high affinity with the tooth component, and the acidic group-containing (co) polymer (A) component that causes the aggregation phenomenon of the fine particles in the dentinal tubule are combined with the component (C ) Even when stored for a long time in an environment in which water is present (even if stored for a long time in the coexistence state of components (A), (B), and (C)), the aggregation reaction of these components hardly occurs. First, it can be put to practical use.

Here, the term “long-term storage” is preferably 12 months or longer, more preferably 24 months or longer, and even more preferably 36 months or longer under the condition of a temperature of 25 ° C.
As a method for using the dental abrasive composition having the effect of suppressing hypersensitivity of the present invention, all components are kneaded, stored in a storage container such as a tube, and then attached to a dental medical handpiece, a polishing brush For example, a method of taking out an appropriate amount of the kneaded composition and applying it directly to the tooth surface, a method of taking out directly to a toothbrush as a normal dentifrice, a method of brushing teeth, a method of taking out directly on a brush, etc., etc. be able to.
〔Example〕
EXAMPLES Hereinafter, although an Example further demonstrates this invention in detail, this invention is not limited at all by an Example.
<Example of preparation of aqueous emulsion>
Distilled water (50 g) was charged into a reactor equipped with a stirrer, a condenser, a thermometer, a nitrogen inlet, and a dropping funnel, heated to 60 ° C., and nitrogen gas was bubbled for 1 hour.

  Then, under a nitrogen atmosphere, 2.0 g of methyl methacrylate (MMA), 0.54 g of sodium styrenesulfonate, 30 mg of potassium persulfate and 10 mg of sodium hydrogensulfite were added, and the mixture was vigorously stirred at 60 ° C. for 2.5 hours.

Further, 1.0 g of MMA, 15 mg of potassium persulfate, and 7 mg of sodium hydrogen sulfite were added four times at 30 minute intervals, and then vigorously stirred for 19.5 hours.
After cooling to room temperature, 0.19 ml of concentrated hydrochloric acid was added and stirred for 2 hours. The mixture was placed in a dialysis tube and dialyzed repeatedly while exchanging distilled water every day for 5 days. The tube was dried at room temperature and normal pressure to obtain an aqueous emulsion having a solid content of 22.0%.

The content of MMA unit in this polymer was 96.9 mol% from elemental analysis, and the number average molecular weight determined by GPC (polystyrene equivalent molecular weight in N, N-dimethylformamide mobile phase) analysis was 100,000 or more.

When the emulsion polymer emulsion particles were observed by transmission microscope observation, the diameter of the particles contained in the emulsion was in the range of 0.1 to 0.5 μm, and a laser diffraction / scattering type particle size distribution measuring apparatus. It was confirmed that the diameter of all the emulsion particles contained by (LA-910, manufactured by Horiba Co., Ltd.) is 1 μm or less. Hereinafter, this aqueous emulsion is referred to as MSE.
<Example of production of aqueous polymer>
A reactor equipped with a stirrer, a condenser, a thermometer, a nitrogen inlet, and a dropping funnel, 200 g of distilled water, 31.8 g (0.2 mol) of 2,3-dihydroxypropyl methacrylamide, 2-acrylamide-2- Methylpropanesulfonic acid 10.4 g (0.05 mol), ammonium persulfate 1.1 g, sodium sulfite 0.6 g were charged, nitrogen gas was bubbled for 15 minutes, and the internal temperature was raised to 70 ° C. while stirring. After performing the polymerization for 2 hours, it was cooled to room temperature.

The reaction mass was purified by reprecipitation with acetone / methanol to obtain 30 g of an aqueous polymer having a dry, colorless number average molecular weight of 100,000 or more. Hereinafter, this aqueous polymer is referred to as MCP.
<Abrasive evaluation method>
The human upper anterior teeth, which were conveniently removed within one week of use and stored in physiological saline, were washed with distilled water. Composition 0 in a rubber cup (Mersage Cup No. 2 web software, Matsukaze Co., Ltd.) attached to a handpiece of a dental motor (Rotary Master, Morita Co., Ltd.)
. 1 g was taken out and the human labial enamel was polished for 10 seconds at a speed of 3000 rpm.

The three items of “sag”, “scattering” of the composition during polishing, and macroscopic findings on the surface of the enamel after polishing were classified into three stages, and were evaluated comprehensively with 10 specimens.
<Production of dentin model>
The bovine front teeth extracted and stored frozen were thawed immediately before use, and a dentin plate of about 10 × 10 × 2 mm was cut out under water injection with a low-speed rotating diamond cutter (ISOMET, manufactured by BUEHLER). After polishing and smoothing the cutting surface with water-resistant abrasive paper (# 600), toothbrush with a dentifrice (White & White, manufactured by Lion Co., Ltd.) on one side of the dentin surface (Doctor Be Young, Bebrand Medico Dental) And made with a force of 20 to 30 g / cm ² under water injection for 3 minutes.

After washing with purified water, it was further washed by applying ultrasonic waves in purified water for 35 minutes, and the brushed surface was used as a dentin model.
<Evaluation method for suppression of hypersensitivity>
Apparent moisture was removed from the surface of the dentin model taken out of water by air blow and dried.

Composition 0. A rubber cup (Mersage Cup No. 2 web software, Matsukaze Co., Ltd.) attached to a handpiece of a dental motor (Rotary Master, Morita Co., Ltd.).
1 g was taken out and the dentin model surface was polished at 3000 rpm for 10 seconds. Subsequently, the polished surface was cleaned with distilled water and dried. The occlusion state of the dentinal tubule was observed with a scanning electron microscope (SEM-5610LV, manufactured by JEOL Ltd.) that was magnified 1500 times.

  The blocking condition of the dentinal tubules was evaluated by the average of 5 specimens using the dentinal tubule blocking ratio of the following formula.

[Example 1]
72.7 g of MSE (16.0 g as a polymer content), 6.2 g of HAP (baked product, average particle size 5 μm), 1.6 g of polyvinyl alcohol (average molecular weight 500), and 19.5 g of distilled water are sufficiently kneaded in an agate mortar. The obtained composition was stored in a glass sealed container. The viscosity of the composition thus obtained at 36 ° C. was 110 Pa · s.

Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 2]
MSE 72.7 g (16.0 g as a polymer content), HAP (baked product, average particle size 5 μm) 6.2 g, oxalic acid 0.4 g, polyvinyl alcohol (average molecular weight 500) 1.6 g, distilled water 19.1 g The mixture was sufficiently kneaded in a mortar, and the resulting composition was stored in a glass sealed container. The viscosity of the composition thus obtained at 36 ° C. was 112 Pa · s.

Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 3]
MSE 72.7g (16.0g as polymer content), HAP (baked product, average particle size 20μm) 6.2g, HAP (unfired product, average particle size 5μm) 0.6g, oxalic acid 0.4g, polyvinyl alcohol ( 1.6 g of average molecular weight 500) and 18.5 g of distilled water were sufficiently kneaded in an agate mortar, and the resulting composition was stored in a glass sealed container. The viscosity of the composition thus obtained at 36 ° C. was 121 Pa · s.

Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 4]
MSE 72.7g (16.0g as a polymer content), β-TCP (baked product, average particle size 5µm) 6.2g, oxalic acid 0.4g, polyvinyl alcohol (average molecular weight 500) 1.6g, distilled water 19.1g Was sufficiently kneaded in an agate mortar, and the resulting composition was stored in a glass sealed container.

The viscosity of the composition thus obtained at 36 ° C. was 113 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 5]
MSE 72.7g (16.0g as polymer content), DCP (average particle size 1µm) 1.7g, TTCP (average particle size 20µm) 4.7g, oxalic acid 0.4g, polyvinyl alcohol (average molecular weight 500) 1.6g Then, 18.9 g of distilled water was sufficiently kneaded in an agate mortar, and the resulting composition was stored in a closed glass container.

The viscosity of the composition thus obtained at 36 ° C. was 115 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 6]
16.0 g of MCP, 6.2 g of HAP (baked product, average particle size 5 μm), 15.0 g of polyvinyl alcohol (average molecular weight 500) and 62.8 g of distilled water were sufficiently kneaded in an agate mortar, and the resulting composition was obtained. Stored in a glass sealed container.

The viscosity of the composition thus obtained at 36 ° C. was 75 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 7]
MCP 16.0 g, HAP (baked product, average particle size 5 μm) 6.2 g, oxalic acid 0.4 g, polyvinyl alcohol (average molecular weight 500) 15.0 g, distilled water 62.4 g were sufficiently kneaded in an agate mortar, The obtained composition was stored in a glass sealed container.

The viscosity of the composition thus obtained at 36 ° C. was 79 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 8]
MCP 16.0 g, HAP (baked product, average particle size 20 μm) 6.2 g, HAP (unfired product, average particle size 5 μm) 0.6 g, oxalic acid 0.4 g, polyvinyl alcohol (average molecular weight 500) 15.0 g, 61.8 g of distilled water was sufficiently kneaded in an agate mortar, and the resulting composition was stored in a closed glass container.

The viscosity of the composition thus obtained at 36 ° C. was 82 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 9]
MCP 16.0 g, β-TCP (baked product, average particle size 5 μm) 6.2 g, oxalic acid 0.4 g, polyvinyl alcohol (average molecular weight 500) 15.0 g, and distilled water 62.4 g are sufficiently kneaded in an agate mortar. The obtained composition was stored in a glass sealed container.

The viscosity of the composition thus obtained at 36 ° C. was 78 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 10]
MCP 16.0 g, DCP (average particle size 1 μm) 1.7 g, TTCP (average particle size 20 μm) 4.7 g, oxalic acid 0.4 g, polyvinyl alcohol (average molecular weight 500) 15.0 g
Then, 62.2 g of distilled water was sufficiently kneaded in an agate mortar, and the resulting composition was stored in a closed glass container.

The viscosity of the composition thus obtained at 36 ° C. was 80 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 11]
MSE72.7g (16.0g as a polymer content), HAP (baked product, average particle size 5 μm) 6.2g, polyvinyl alcohol (average molecular weight 500) 1.6g, sodium fluoride 0.5g, distilled water 19.0g The mixture was sufficiently kneaded in an agate mortar, and the resulting composition was stored in a glass sealed container.

The viscosity of the composition thus obtained at 36 ° C. was 116 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 12]
72.7 g of MSE (16.0 g as a polymer content), 6.2 g of HAP (baked product, average particle size 5 μm), 1.6 g of polyvinyl alcohol (average molecular weight 500), 3.5 g of hydrogen peroxide (30% aqueous solution), 16.0 g of distilled water was sufficiently kneaded in an agate mortar, and the resulting composition was stored in a glass sealed container.

The viscosity of the composition thus obtained at 36 ° C. was 95 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 13]
MSE 72.7 g (16.0 g as a polymer content), HAP (baked product, average particle size 5 μm) 6.2 g, polyvinyl alcohol (average molecular weight 500) 1.6 g, anatase type titanium oxide (Super Titania, Showa Denko KK) Manufactured, average particle size of 6 nm, aggregated particles were SEM image magnified 15,000 times, 0.1-2 μm particles could be confirmed) 0.1 g and 19.4 g of distilled water were sufficient in an agate mortar The resulting composition was stored in a glass sealed container.

The viscosity of the composition thus obtained at 36 ° C. was 131 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 14]
16.0 g of MCP, 6.2 g of HAP (baked product, average particle size 5 μm), 15.0 g of polyvinyl alcohol (average molecular weight 500), 0.5 g of sodium fluoride and 62.3 g of distilled water were sufficiently kneaded in an agate mortar. The resulting composition was stored in a glass sealed container.

The viscosity of the composition thus obtained at 36 ° C. was 77 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 15]
MCP 16.0 g, HAP (baked product, average particle size 5 μm) 6.2 g, polyvinyl alcohol (average molecular weight 500) 15.0 g, hydrogen peroxide solution (30% aqueous solution) 3.5 g, distilled water 5
9.3 g was sufficiently kneaded in an agate mortar, and the obtained composition was stored in a glass sealed container.

The viscosity of the composition thus obtained at 36 ° C. was 66 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Example 16]
MCP 16.0 g, HAP (baked product, average particle size 5 μm) 6.2 g, polyvinyl alcohol (average molecular weight 500) 15.0 g, anatase type titanium oxide (Super Titania, Showa Denko, average particle size 6 nm, particles after aggregation Is an SEM image magnified 15,000 times and particles of 0.1 to 2 μm were confirmed) 0.1 g and 62.7 g of distilled water were sufficiently kneaded in an agate mortar, and the resulting composition was glass Stored in a sealed container.

The viscosity of the composition thus obtained at 36 ° C. was 87 Pa · s.
Moreover, the obtained composition was taken out just before use, and the above-mentioned abrasive evaluation and hypersensitivity suppression evaluation were performed. The results are listed in Table 1.
[Comparative Example 1]
0.1 g of a commercially available dental abrasive (Melsage, Regular, Matsukaze Co., Ltd.) was taken out, and the above-described abrasive evaluation and hypersensitivity suppression evaluation were performed.
The results are listed in Table 1.

<Abrasive evaluation>
Sauce: ○ ·· No “sag” of the composition.
Δ ·· Slight “sag” occurred in the composition.

X. Excessive "sag" occurred in the composition.
Spattering: ○ ··· No scattering of the composition.
Δ ·· A small amount of the composition was scattered.

X. The composition was scattered excessively.
Macroscopic findings on the enamel surface:
○ ・ ・ Glossy.

Δ ··· Partially not polished or cloudy.
× · · · There are excessive scratches.

  The perceptual hypersensitivity dental abrasive composition of the present invention has high tooth polishing performance and high operability. Moreover, this composition can remarkably suppress hypersensitivity induced during tooth polishing.

Claims (8)

(A) selected from the group consisting of a radical polymerizable monomer having an acidic group in the molecule, a radical polymerizable monomer having a functional group easily converted into an acidic group in water in the molecule, and salts thereof. An acidic group-containing (co) polymer formed by (co) polymerizing at least one radical polymerizable monomer,
(B) inorganic calcium salt,
(C) water,
A dental abrasive composition for suppressing hypersensitivity, comprising:   The above-mentioned acidic group-containing (co) polymer (A) component is a radically polymerizable monomer having a sulfonic acid group in the molecule, and a radically polymerizable property having a functional group that is easily converted into a sulfonic acid group in water in the molecule. The sulfonic acid group-containing (co) polymer obtained by (co) polymerizing at least one kind of radically polymerizable monomer selected from the group consisting of a monomer and a salt thereof, 2. A perceptual hypersensitivity dental abrasive composition according to item 1.   The acidic group-containing (co) polymer (A) component is at least one polymer selected from the group consisting of styrenesulfonic acid, 2- (meth) acrylamide-2-methylpropanesulfonic acid, and salts thereof. The perceptual hypersensitivity dental abrasive composition according to claim 2, wherein the monomer is (co) polymerized. The inorganic calcium salt component _{(B), CaHPO 4, Ca 3 (PO} 4) 2, Ca 5 (PO 4) 3 OH, Ca 4 O (PO 4) 2, Ca 8 H 2 (PO 4) 6, Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ , CaP ₄ O ₁₁ , Ca (PO ₃ ) ₂ , Ca ₂ P ₂ O ₇ , Ca (H ₂ PO ₄ ) ₂ , CaO, Ca (OH) ₂ , C
2. The hypersensitive hypersensitive dental abrasive composition according to claim 1, which is at least one inorganic calcium salt selected from the group consisting of aCO ₃ and hydrates thereof.   The perceptual hypersensitivity dental polishing composition according to any one of claims 1 to 4, wherein the perceptual hypersensitivity dental abrasive composition further comprises (D) an acidic compound. Material composition.   The hypersensitive hypersensitive dental polishing composition according to any one of claims 1 to 4, wherein the perceptual hypersensitive dental abrasive composition further comprises (E) a fluorine compound. Material composition.   5. The perceptual hypersensitivity dental abrasive composition further comprises (F) hydrogen peroxide and / or urea peroxide, according to any one of claims 1 to 4. A dental abrasive composition for suppressing hypersensitivity.   The hypersensitive hypersensitive dental polishing composition according to any one of claims 1 to 4, wherein the perceptual hypersensitive dental abrasive composition further contains (G) a titanium compound. Material composition.