JP2008088095A - Method for suppressing buildup of dental plaque - Google Patents
Method for suppressing buildup of dental plaque Download PDFInfo
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- JP2008088095A JP2008088095A JP2006269956A JP2006269956A JP2008088095A JP 2008088095 A JP2008088095 A JP 2008088095A JP 2006269956 A JP2006269956 A JP 2006269956A JP 2006269956 A JP2006269956 A JP 2006269956A JP 2008088095 A JP2008088095 A JP 2008088095A
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- antibacterial agent
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- 238000000034 method Methods 0.000 title claims abstract description 17
- 208000002064 Dental Plaque Diseases 0.000 title abstract description 5
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 23
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229910052709 silver Inorganic materials 0.000 claims abstract description 14
- 239000004332 silver Substances 0.000 claims abstract description 14
- 239000010457 zeolite Substances 0.000 claims abstract description 14
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229910021536 Zeolite Inorganic materials 0.000 claims abstract description 13
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 12
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000010949 copper Substances 0.000 claims abstract description 12
- 229910052802 copper Inorganic materials 0.000 claims abstract description 12
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 12
- 239000011701 zinc Substances 0.000 claims abstract description 12
- 239000011521 glass Substances 0.000 claims abstract description 9
- 229910052751 metal Inorganic materials 0.000 claims abstract description 7
- 239000002184 metal Substances 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 4
- 229910021645 metal ion Inorganic materials 0.000 claims description 8
- 239000013078 crystal Substances 0.000 claims description 4
- 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 210000002200 mouth mucosa Anatomy 0.000 abstract description 5
- 150000002739 metals Chemical class 0.000 abstract 3
- 150000002500 ions Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 7
- 239000013013 elastic material Substances 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 3
- 208000025157 Oral disease Diseases 0.000 description 3
- 229910004298 SiO 2 Inorganic materials 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000030194 mouth disease Diseases 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- NJLLQSBAHIKGKF-UHFFFAOYSA-N dipotassium dioxido(oxo)titanium Chemical compound [K+].[K+].[O-][Ti]([O-])=O NJLLQSBAHIKGKF-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000005038 ethylene vinyl acetate Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 208000028169 periodontal disease Diseases 0.000 description 2
- -1 phosphate compound Chemical class 0.000 description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 208000032484 Accidental exposure to product Diseases 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229910010413 TiO 2 Inorganic materials 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- JYIBXUUINYLWLR-UHFFFAOYSA-N aluminum;calcium;potassium;silicon;sodium;trihydrate Chemical compound O.O.O.[Na].[Al].[Si].[K].[Ca] JYIBXUUINYLWLR-UHFFFAOYSA-N 0.000 description 1
- 229910052908 analcime Inorganic materials 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 206010006514 bruxism Diseases 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229910001603 clinoptilolite Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910000664 lithium aluminum titanium phosphates (LATP) Inorganic materials 0.000 description 1
- 229910052680 mordenite Inorganic materials 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052665 sodalite Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001738 temporomandibular joint Anatomy 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Description
本発明は、う蝕や歯周病等の口腔内疾患の原因となる歯垢の歯面への付着を抑制する方法に関する。 The present invention relates to a method for suppressing adhesion of dental plaque, which causes oral diseases such as caries and periodontal disease, to the tooth surface.
口腔内疾患の代表例としては、う蝕症（むし歯），歯周病（歯槽膿漏）を挙げることができる。これらの疾患は、口腔内細菌による感染症の１種と考えられている。これらの疾患の予防においては歯垢の速やかな除去が重要とされている。しかし最も重要なことは歯垢を歯面に付着させないことである。 Representative examples of oral diseases include caries disease (cavities) and periodontal disease (alveolar pyorrhea). These diseases are considered as one type of infection caused by oral bacteria. Prompt removal of plaque is considered important in preventing these diseases. However, the most important thing is not to allow plaque to adhere to the tooth surface.
歯垢の付着を抑制する方法としては、クロロヘキシジン等の有機抗菌剤や、銀，銅，亜鉛などの無機抗菌剤や、抗菌性金属イオンを担持したゼオライト等を、歯磨剤や洗口剤等に配合した歯科用組成物が開示されている（例えば特許文献１〜５参照。）。 To prevent plaque adhesion, organic antibacterial agents such as chlorohexidine, inorganic antibacterial agents such as silver, copper and zinc, and zeolites carrying antibacterial metal ions can be used as toothpastes and mouthwashes. The compounded dental composition is disclosed (for example, refer patent documents 1-5).
しかしながら、歯磨剤や洗口剤は使用方法の特性上、口から体内へ入ってしまう量が多く、誤飲の危険性もある。また歯磨剤や洗口剤は口腔内で数十秒間しか適用されないため強力な抗菌剤（主に有機合成系抗菌剤）を高濃度で用いることが必要であり口腔粘膜への安全性の面で問題がある。更に、歯磨剤や洗口剤は口腔内全体の幅広い範囲に作用してしまうため、口腔内疾患に関与しない常在菌まで影響を与えてしまう。 However, dentifrices and mouthwashes often enter the body from the mouth due to the characteristics of the method of use, and there is a risk of accidental ingestion. In addition, since dentifrices and mouthwashes are applied only within the oral cavity for several tens of seconds, it is necessary to use strong antibacterial agents (mainly organic synthetic antibacterial agents) at high concentrations, and in terms of safety to the oral mucosa. There's a problem. Furthermore, since dentifrices and mouthwashes act on a wide range of the entire oral cavity, they affect even resident bacteria that are not involved in oral diseases.
そこで本発明は、口から体内へ入る量が少なく、生体全体や口腔粘膜に害を及ぼす虞がない、更には歯垢の付着を抑制させたい箇所に対して選択的に適用することが可能な歯垢の付着抑制方法を提供することを課題とする。 Therefore, the present invention has a small amount entering the body from the mouth, has no possibility of harming the whole living body and oral mucosa, and can be selectively applied to a place where it is desired to suppress adhesion of plaque. It is an object of the present invention to provide a method for suppressing plaque adhesion.
本発明者等は前記課題を解決するために鋭意検討した結果、外傷（歯牙の破折や顎関節の骨折など）に対する保護を目的として使用されていたマウスピースの基材に粉末状の無機系抗菌剤を混合し、該マウスピースを口腔内へ装着させれば前記課題を解決できることを究明して本発明を完成したのである。 As a result of intensive studies to solve the above problems, the present inventors have found that a powdery inorganic system is used as a base material for a mouthpiece that has been used for the purpose of protecting against trauma (such as fracture of a tooth or fracture of a temporomandibular joint). The present invention was completed by investigating that the above problem could be solved by mixing an antibacterial agent and mounting the mouthpiece in the oral cavity.
即ち本発明は、粉末状の無機系抗菌剤が混合されたマウスピースを装着することを特徴とする歯垢の付着抑制方法である。 That is, the present invention is a method for suppressing plaque adhesion, comprising mounting a mouthpiece mixed with a powdery inorganic antibacterial agent.
本発明に係る歯垢の付着抑制方法は、抗菌剤が口から体内へ入ってしまう量が少なく、生体全体や口腔粘膜に害を及ぼす虞が少なく、更には歯垢の付着を抑制させたい箇所に対して選択的に抗菌剤を適用することが可能な優れた方法である。 The method for inhibiting the adhesion of plaque according to the present invention has a small amount of antibacterial agent entering the body from the mouth, has a low risk of harming the whole living body and oral mucosa, and further a place where it is desired to suppress the adhesion of plaque. It is an excellent method capable of selectively applying an antibacterial agent.
本発明方法で使用するマウスピースの基材としては、従来から歯科やスポーツ分野で使用されているマウスガードやマウスピースの基材が使用できる。本発明で用いるマウスピースは弾性材から成りその弾性材に粉末状の無機系抗菌剤が混合されている。弾性材としては、例えばポリオレフィン系軟質弾性材やエチレン−酢酸ビニルコポリマー等が挙げられる。また、従来の歯科治療において矯正やブラキシズムの治療に用いられていた樹脂系の材料をマウスピースの基材とすることもできる。この樹脂系の材料は光重合，加熱重合，常温重合の何れの重合体系でも使用できる。 As the mouthpiece base material used in the method of the present invention, a mouth guard or mouthpiece base material conventionally used in the dentistry or sports field can be used. The mouthpiece used in the present invention is made of an elastic material, and a powdered inorganic antibacterial agent is mixed with the elastic material. Examples of the elastic material include a polyolefin-based soft elastic material and an ethylene-vinyl acetate copolymer. In addition, a resin-based material that has been used for orthodontic treatment and bruxism treatment in conventional dental treatment can be used as the base material of the mouthpiece. This resin material can be used in any polymerization system such as photopolymerization, heat polymerization, and room temperature polymerization.
マウスピースに混合される粉末状の無機系抗菌剤は抗菌性を持つ金属粉末または金属元素，金属イオンを無機質の担体に含ませた物質である。例えば、銀，銅，亜鉛の中から１種または２種以上が選択された金属粉末、銀，銅，亜鉛の中から１種または２種以上が選択された金属イオンを担持したゼオライト、或いは結晶格子の一部が銀，銅，亜鉛の中から１種または２種以上が選択された金属イオンに置換されている結晶化ガラス、銀，銅，亜鉛の中から１種または２種以上が選択された金属イオンを担持したリン酸塩系化合物の何れかであることが好ましい。その他にもケイ酸カルシウム，炭酸カルシウム，酸化アルミ，活性炭，酸化チタン，チタン酸カリウム等も使用できる。 The powdered inorganic antibacterial agent mixed with the mouthpiece is a substance in which an antibacterial metal powder or metal element or metal ion is contained in an inorganic carrier. For example, a metal powder selected from one or more of silver, copper and zinc, a zeolite or a crystal carrying a metal ion selected from one or more of silver, copper and zinc Select one or more of crystallized glass, silver, copper, or zinc, where a part of the lattice is replaced with metal ions selected from one or more of silver, copper, and zinc It is preferable that any one of the phosphate compounds carrying the supported metal ions. In addition, calcium silicate, calcium carbonate, aluminum oxide, activated carbon, titanium oxide, potassium titanate, etc. can be used.
ゼオライトとしては、天然ゼオライト及び合成ゼオライトの何れも使用できる。特に限定されるものではないが、例えばＡ−型ゼオライト、Ｘ−型ゼオライト、Ｙ−型ゼオライト、Ｔ−型ゼオライト、高シリカゼオライト、ソーダライト、モルデナイト、アナルサイム、クリノプチロライト、チャバサイト、エリオナイト等を挙げることができる。中でも、不純物の混入率が低い合成ゼオライトが好ましい。 As zeolite, both natural zeolite and synthetic zeolite can be used. Although not particularly limited, for example, A-type zeolite, X-type zeolite, Y-type zeolite, T-type zeolite, high silica zeolite, sodalite, mordenite, analcime, clinoptilolite, chabasite, erio A knight etc. can be mentioned. Among these, synthetic zeolite having a low impurity mixing rate is preferable.
結晶化ガラスとしては、（Ｂａ，Ｓｒ，Ｃａ）Ｏ− Ａｌ２Ｏ３ − ＴｉＯ２ −ＳｉＯ２ 系結晶化ガラス、（Ｂａ，Ｓｒ，Ｃａ）Ｏ− Ａｌ２ Ｏ３ − ＳｉＯ２ 系結晶化ガラスまたはＮａ２ Ｏ − Ｋ２ Ｏ− Ａｌ２ Ｏ３ − Ｂ２ Ｏ３ − ＳｉＯ２ 系結晶化ガラスを挙げることができるが、これ以外のガラスであっても加熱することにより結晶を析出するものであれば使用することができる。 The crystallized glass, (Ba, Sr, Ca) O- Al 2 O 3 - TiO 2 -SiO 2 based crystallized glass, (Ba, Sr, Ca) O- Al 2 O 3 - SiO 2 based crystallized glass Or, Na 2 O—K 2 O—Al 2 O 3 —B 2 O 3 —SiO 2 -based crystallized glass can be mentioned, but even other glasses can precipitate crystals by heating. Can be used if present.
リン酸塩系化合物としては、ハイドロキシアパタイト、リン酸３カルシウム、フッ素アパタイトが挙げられる。これらのリン酸カルシウム化合物は単独で用いても、または混合物として用いてもよい。 Examples of the phosphate compound include hydroxyapatite, tricalcium phosphate, and fluorine apatite. These calcium phosphate compounds may be used alone or as a mixture.
粉末状の無機系抗菌剤はマウスピース基材中に０．１〜１０重量％配合されていることが好ましい。０．１重量％より少ないと歯垢の付着を抑制する効果が低く、１０重量％よりも多いとマウスピースの耐久性が低下する。 The powdered inorganic antibacterial agent is preferably blended in an amount of 0.1 to 10% by weight in the mouthpiece base material. If it is less than 0.1% by weight, the effect of suppressing the adhesion of plaque is low, and if it is more than 10% by weight, the durability of the mouthpiece is lowered.
粉末状の無機系抗菌剤は有機系の抗菌剤と比較して抗菌の作用が低い傾向があるが、本発明に係る歯垢の付着抑制方法においてはマウスピースの特性を利用するので長時間かけて、必要であれば抗菌剤を作用させる箇所を選択して、生体全体や口腔粘膜には害を及ぼさずに歯垢の付着を抑制することが可能となる。抗菌剤を作用させる箇所を選択する方法としては、例えば、一部分にのみ粉末状の無機系抗菌剤を混合したマウスピースを用いる方法がある。 Powdered inorganic antibacterial agents tend to have a lower antibacterial effect than organic antibacterial agents, but the method for inhibiting plaque adhesion according to the present invention takes advantage of the characteristics of a mouthpiece and takes a long time. Then, if necessary, the place where the antibacterial agent is applied can be selected to suppress the adhesion of plaque without causing any harm to the whole living body or the oral mucosa. As a method for selecting a place where an antibacterial agent is to be applied, for example, there is a method using a mouthpiece in which a powdered inorganic antibacterial agent is mixed only in part.
＜実施例１＞
エチレン−酢酸ビニルコポリマーを１２０℃に加熱し軟化させ、銀を担持した合成ゼオライトの抗菌剤（商品名：ゼオミック、シナネン社製）、結晶格子の一部が銀イオンで置換された結晶化ガラスの抗菌剤（商品名：ＬＡＴＰ，住田光学ガラス社製）、銀を担持したチタン酸カリウムの抗菌剤（商品名：バイカムＡＫ、大塚化学社製）を表１に示した配合量で添加し、型に入れてから冷却し、２００ｍｍ×２００ｍｍ、厚さ１ｍｍのシートを作製した。このシートから通法に従い被験者用の上下顎のフルサイズマウスピースを作製して歯垢付着の抑制効果を確認した。
<Example 1>
A synthetic zeolite antibacterial agent (trade name: Zeomic, manufactured by Sinanen Co., Ltd.), which is softened by heating an ethylene-vinyl acetate copolymer to 120 ° C., and a crystallized glass in which a part of the crystal lattice is replaced with silver ions. An antibacterial agent (trade name: LATP, manufactured by Sumita Optical Glass Co., Ltd.), an antibacterial agent of potassium titanate supporting silver (trade name: Baicom AK, manufactured by Otsuka Chemical Co., Ltd.) was added in the amounts shown in Table 1, and the mold was added. The sheet was then cooled to prepare a sheet having a size of 200 mm × 200 mm and a thickness of 1 mm. A full-size mouthpiece for the subject's upper and lower jaws was prepared from this sheet according to the usual method, and the effect of suppressing plaque adhesion was confirmed.
＜表１＞
＋＋：歯垢の付着が確認されなかった
＋：僅かな歯垢の付着が確認された
−：歯垢の付着が確認された
++: Plaque adhesion was not confirmed +: Slight plaque adhesion was confirmed-: Plaque adhesion was confirmed
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| JP2006269956A JP2008088095A (en) | 2006-09-29 | 2006-09-29 | Method for suppressing buildup of dental plaque |
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| JP2006269956A JP2008088095A (en) | 2006-09-29 | 2006-09-29 | Method for suppressing buildup of dental plaque |
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| JP2008088095A true JP2008088095A (en) | 2008-04-17 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8469709B2 (en) | 2011-02-08 | 2013-06-25 | Puthalath Koroth Raghuprasad | Dental hygiene device |
| US8721331B2 (en) | 2011-10-11 | 2014-05-13 | Puthalath Koroth Raghuprasad | Oral transmucosal drug delivery device |
| US8753116B2 (en) | 2011-02-08 | 2014-06-17 | Puthalath Koroth Raghuprasad | Dental hygiene device |
| JP2022190418A (en) * | 2021-06-14 | 2022-12-26 | 株式会社スタティックジャパン | Dental resin material, and antibacterial artificial tooth |
-
2006
- 2006-09-29 JP JP2006269956A patent/JP2008088095A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8469709B2 (en) | 2011-02-08 | 2013-06-25 | Puthalath Koroth Raghuprasad | Dental hygiene device |
| US8753116B2 (en) | 2011-02-08 | 2014-06-17 | Puthalath Koroth Raghuprasad | Dental hygiene device |
| US8721331B2 (en) | 2011-10-11 | 2014-05-13 | Puthalath Koroth Raghuprasad | Oral transmucosal drug delivery device |
| US9987196B2 (en) | 2011-10-11 | 2018-06-05 | Puthalath Koroth Raghuprasad | Oral transmucosal drug delivery device |
| JP2022190418A (en) * | 2021-06-14 | 2022-12-26 | 株式会社スタティックジャパン | Dental resin material, and antibacterial artificial tooth |
| JP7773173B2 (en) | 2021-06-14 | 2025-11-19 | 株式会社スタティックジャパン | Dental resin materials and antibacterial dentures |
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