JP2007014866A - Method for preparing oil in water microemulsion composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method for preparing an oil in water microemulsion composition capable of efficiently micronizing the emulsified particles by a simple and high temperature emulsifying process. <P>SOLUTION: The method for preparing an oil in water microemulsion composition comprises processes of mixing and stirring (A) an aqueous solvent, (B) a nonionic surfactant, (C) an oil component, to prepare an emulsion composition of an oil in aqueous solvent type; and adding an aqueous formulation (D) to the resulting emulsion composition of an oil in aqueous solvent type to prepare an oil in water emulsion composition, which is characterized in that the aqueous solvent (A) comprises a polyoxypropylene-polyoxyethylene random copolymer dialkyl ether. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a method for producing an oil-in-water microemulsion composition, and particularly to improvement of the formulation stability.

In the non-aqueous emulsification method, a hydrophilic nonionic surfactant is added to an aqueous solvent, and an oil is added thereto to create an oil-in-water emulsion in an aqueous solvent, and water is further added to the oil-in-water emulsion in the aqueous solvent. In this method, an oil-in-water emulsion is obtained, and polyhydric alcohols (particularly divalent glycols) are used as the aqueous solvent (see, for example, Patent Document 1). This non-aqueous emulsification method can blend a large amount of oil with a smaller amount of surfactant than other emulsification methods. Therefore, when the emulsified composition produced by the non-aqueous emulsification method is used as a skin external preparation such as cosmetics, there is an advantage that a product with little stickiness can be obtained.
JP 57-29213 A

However, the conventional non-aqueous emulsification method is not sufficient to make the emulsified particles fine, and the stability of the emulsified composition is somewhat problematic. Further, when emulsification is performed at a high temperature, the particle size of the emulsified particles is further increased, and it has been particularly difficult to sufficiently reduce the solid or semi-solid oil content. In addition, other methods have problems such as a large amount of surfactant relative to the amount of oil and a special and inefficient production process such as high-pressure emulsification.
The present invention has been made in view of the above problems, and its object is to provide a method for producing an oil-in-water microemulsion composition capable of sufficiently miniaturizing emulsified particles even when emulsified at a high temperature in a simple process. There is to do.

In order to achieve the above object, the present inventors have conducted extensive research, and as a result, polyoxypropylene / polyoxyethylene random copolymer dialkyl ether is used as an aqueous solvent in the non-aqueous emulsification method. Has been found to be small, and the present invention has been completed.
That is, in the method for producing an oil-in-water fine emulsion composition according to the present invention, (A) an aqueous solvent, (B) a nonionic surfactant, and (C) an oil component are mixed and stirred to obtain an oil-in-water emulsion composition in an aqueous solvent. And (D) adding an aqueous formulation to the oil-in-water emulsion composition in an aqueous solvent to prepare an oil-in-water emulsion composition, and (A) polyoxypropylene in the aqueous solvent. -Polyoxyethylene random copolymer dialkyl ether is included.

In said manufacturing method, it can prepare suitably at the temperature of 70 degreeC or more by the said oil-in-water emulsion composition preparation process at least.
In the above production method, it is preferable that the oil component (C) contains a solid or semi-solid oil component at room temperature.
In said manufacturing method, it is suitable that the quantity of said (C) oil content with respect to the quantity of said (B) nonionic surfactant is 5 times or more.
In said manufacturing method, the emulsion particle diameter of the said oil-in-water type fine emulsion composition can be suitably 0.3 micrometer or less.
In the above production method, it is preferable that the (A) aqueous solvent contains polyoxyethylene / polyoxypropylene random copolymer dimethyl ether.
In the above production method, it is more preferable that the (C) oil contains one or more higher alcohols or higher fatty acids that are liquid at room temperature.

  According to the method for producing an oil-in-water fine emulsion composition according to the present invention, since a polyoxypropylene / polyoxyethylene random copolymer dialkyl ether is used as an aqueous solvent, fine emulsified particles even when emulsified at a high temperature An emulsified composition having a diameter can be obtained.

  The method for producing an oil-in-water fine emulsion composition according to the present invention comprises (A) an aqueous solvent, (B) a nonionic surfactant, and (C) an oil component mixed and stirred to prepare an oil-in-water emulsion composition in an aqueous solvent. And (D) adding an aqueous formulation to the oil-in-water emulsion composition in an aqueous solvent to prepare an oil-in-water emulsion composition, and (A) the polyoxypropylene-polyethylene in the aqueous solvent. An oxyethylene random copolymer dialkyl ether is included. And even if it emulsifies at the temperature higher than normal temperature (for example, 70 degreeC or more) at least by the said oil-in-water-type emulsion composition adjustment process in the said aqueous solvent, the oil-in-water type fine emulsion composition which has a sufficiently fine emulsion particle diameter can be obtained. it can. In addition, "normal temperature" means 15-25 degreeC.

(A) As the aqueous solvent, among polyoxypropylene / polyoxyethylene random copolymer dialkyl ethers, hydrophilic ones (low compatibility with oil components) are preferable, especially polyoxypropylene / polyoxyethylene random copolymers. Polymer dimethyl ether is preferred. Also, depending on the type of oil and nonionic surfactant to be combined, the average added mole number of polyoxypropylene is 2 to 50, the average added mole number of polyoxyethylene is 8 to 100, polyoxyethylene and polyoxy The ratio [POE / (POE + POP)] of the average number of moles of polyoxyethylene to the total number of moles of propylene added is preferably 0.5 or more. Here, POE and POP are abbreviations for polyoxyethylene and polyoxypropylene, respectively, and may be abbreviated as follows.
The polyoxypropylene / polyoxyethylene random copolymer dialkyl ether can be produced by a known method. For example, it can be obtained by addition-polymerizing ethylene oxide and propylene oxide to a compound having a hydroxyl group, and then ether-reacting an alkyl halide in the presence of an alkali catalyst.

  The content of the POP / POE random copolymer dialkyl ether in the aqueous solvent used in the step of preparing the oil-in-water emulsion composition in the aqueous solvent is preferably 30% by mass or more. For example, when POP / POE copolymer dialkyl ether and water are used as the aqueous solvent, the amount of water in the aqueous solvent should be 0.5 to 2 times (mass ratio) of the POP / POE random copolymer dialkyl ether. Is desirable. The aqueous solvent may contain other aqueous solvents other than water.

The nonionic surfactant (B) used in the present invention is preferably a hydrophilic one (for example, HLB is 12 or more). For example, polyoxyethylene (40 to 100 mol) hydrogenated castor oil, polyoxyethylene ( 10-30 mol) phytosterol, polyoxyethylene (20-30 mol) cholesterol, polyoxyethylene (16-30 mol) octyldodecanol, polyoxyethylene (20-30) behenyl alcohol and the like.
In addition, the type of oil component (C) is not particularly limited, but according to the production method of the present invention, a sufficiently fine emulsified particle diameter can be obtained even when emulsified at a high temperature. And particularly preferably applied. Specifically, waxes such as mole, beeswax, carnauba wax, candelilla wax; higher alcohols such as cetanol, myristyl alcohol, stearyl alcohol, behenyl alcohol; lipids such as cholesterol, phytosterol, phytosterol alkyl ether, ceramide, and the like Derivatives; hydrocarbons such as solid paraffin, petrolatum, microcrystalline wax; lauroyl glutamic acid (phytosteryl / octyldodecyl), lauroyl glutamic acid (phytosteryl / octyldodecyl / behenyl), hydrogenated castor oil, stearic acid hydrogenated castor oil, tetra (ethylhexane) Acid / benzoic acid) pentaerythrityl, tetra (ethylhexanoic acid / benzoic acid / behenic acid) pentaerythrityl and the like. That.

  Furthermore, it is preferable to blend one or two or more higher alcohols or higher fatty acids that are liquid at room temperature in (C) the oil. By blending these in the oil, the emulsified particles are further refined, and a more stable oil-in-water emulsion is obtained. Examples of higher alcohols that are liquid at room temperature include unsaturated higher alcohols such as oleyl alcohol, linoleyl alcohol, and linolenyl alcohol; branched saturated higher alcohols such as isostearyl alcohol, octyldodecyl alcohol, and decyltetradecanol. Is mentioned. Examples of the higher fatty acid that is liquid at room temperature include unsaturated fatty acids such as oleic acid, linoleic acid, and linolenic acid, isostearic acid, isopalmitic acid, and isomyristic acid.

(C) The amount of oil is preferably about 5 to 15 times (mass ratio) with respect to the amount of (B) nonionic surfactant. If it is 5 times or more, the amount of the nonionic surfactant is not so large, so that the resulting oil-in-water emulsion composition has little stickiness and good usability. Moreover, if it is 15 times or less, the oil-in-water-type emulsion composition of a sufficiently fine emulsion particle diameter can be obtained suitably.
Further, the amount of the higher alcohol or higher fatty acid which is liquid at room temperature in the oil component is desirably 5% by mass to 60% by mass, particularly preferably 15% by mass to 40% by mass with respect to the total oil content. It is. Within this range, an oil-in-water emulsion composition having high stability and good usability can be suitably obtained.

In addition, the above (D) aqueous formulation is not particularly limited as long as it is a formulation having water or an aqueous solvent as a main medium. In addition to water or an aqueous solvent, it is usually used for cosmetics, pharmaceuticals, and the like. You may mix | blend the component by the compounding quantity of the range which does not affect stability.
In the preparation process of the oil-in-water emulsion composition in an aqueous solvent, (A) 0.1 to 50% by mass of a POP / POE random copolymer dialkyl ether as an aqueous solvent and 0.05 to 50% by mass of water, (B) It is preferable to blend 0.01 to 10% by mass of the nonionic surfactant and 0.05 to 80% by mass of the oil component (C).
Moreover, in the preparation process of the oil-in-water emulsion composition, the amount of the (D) aqueous formulation relative to the amount of the oil-in-water emulsion composition is not particularly limited, but is preferably 3 to 150 times.

  In the preparation process of the oil-in-water emulsion composition in the aqueous solvent, as shown in FIG. 1A, (A) the nonionic surfactant 14 and the oil 12 are added to the high concentration aqueous solution 10 of POP / POE random copolymer dialkyl ether. And an oil-in-water emulsion in an aqueous solvent is formed. At this time, it is considered that the POP / POE random copolymer dialkyl ether molecules 18 are distributed in the vicinity of the hydrophilic group 16 (polyoxyethylene chain) of the nonionic surfactant 14. Therefore, the distance between the hydrophilic groups 16 of each nonionic surfactant 14 increases, and a force acts in the direction of increasing the curvature toward the oil component 12 with respect to the emulsion. As a result, it is considered that an emulsion having a small emulsified particle size can be obtained. When the oil-in-water emulsion composition in an aqueous solvent is added to the aqueous phase as shown in FIG. 1B, most of the POP / POE dimethyl ether molecules 18 distributed in the vicinity of the hydrophilic group 16 diffuse into the water, An oil-in-water emulsion having an emulsified particle size can be obtained.

  Here, considering the case where the temperature at the time of emulsification is high, the lipophilicity of the hydrophilic group 16 of the nonionic surfactant 14 increases as the temperature increases. Then, since the effective cross-sectional area of the hydrophilic group part of a nonionic surfactant becomes small, there exists a tendency for an emulsion particle diameter to become large. However, since the lipophilicity of the POP / POE dialkyl ether 18 is also increased, the POP / POE dialkyl ether molecules 18 are distributed in a large number on the hydrophilic group 16 portion of the nonionic surfactant 14 even when the temperature rises. . As a result, the above mechanism (increase in effective cross-sectional area of the hydrophilic group portion of the nonionic surfactant 14 by the POP / POE dialkyl ether molecules 18) functions even at high temperatures, and an oil-in-water emulsion having a fine emulsified particle size is obtained. It is thought that can be obtained.

  Thus, according to the production method of the present invention, an emulsified composition having a fine emulsified particle diameter can be obtained even when emulsified at a high temperature with a small amount of a surfactant. Moreover, the oil-in-water emulsion composition manufactured by the manufacturing method concerning this invention can be used conveniently for skin external preparations, such as cosmetics. In particular, since a stable product can be obtained even when blended in a low-viscosity base material, it can be suitably applied to the production of emulsified cosmetics, lotion-like emulsions, lotion-like sunscreens, and the like.

The present invention will be described more specifically below, but the present invention is not limited to the following examples.
First, an oil-in-water emulsion composition is first prepared with the composition (mass%) shown in Tables 1 and 2, and the emulsion particle diameter when emulsified at room temperature, the emulsion particle diameter when emulsified at 70 ° C. or higher, and the emulsion composition The stability of the product and the feel of use of the composition were examined.

Production method (1) (B) Nonionic surfactant in Tables 1 and 2 and (C) Oil component are mixed, and (A) Aqueous solvent is gradually added while being applied to a homomixer at room temperature or 70 ° C. A mold emulsion composition was prepared.
(2) This oil-in-water emulsion in an aqueous solvent was added to (D) the aqueous formulation to obtain an oil-in-water emulsion.
Measurement of the emulsified particle diameter of emulsion particle size resulting oil-in-water emulsion composition was carried out by a light scattering method. The apparatus used was F-PAR-1000 (Otsuka Electronics Co., Ltd.).

Stability The stability of the obtained oil-in-water emulsion composition was determined according to the following criteria after the composition was stored for 1 month under temperature test conditions of 0 ° C., room temperature, 37 ° C. and 50 ° C.
A: No abnormality such as separation or change in appearance is observed at each test temperature. O: Only the composition at the test temperature of 50.degree. C. has a change in appearance. .DELTA .: The appearance of the composition at the test temperature of 37.degree. Change is observed ×: Abnormalities such as separation and changes in appearance are observed even in the composition where the test temperature is room temperature and 0 ° C.

The feeling of use of the obtained oil-in-water emulsion composition was tested as follows. Twenty women's panels evaluated the usability of the composition immediately after preparation, and evaluated it according to the following criteria.
◎: More than 16 panelists evaluated as having no stickiness or oily feel ○: 10 to 15 panels evaluated as having a feel without stickiness or oiliness △: Stickiness or oil 6 to 9 panels evaluated to have a feeling of use without a stickiness ×: 5 or less panels evaluated to have a feeling of use without stickiness or oiliness As shown in Tables 1 and 2, It was found that Test Examples 1-1 to 1-9 using an aqueous solvent that had been used in the non-aqueous emulsification method described above were not sufficiently refined in emulsion particle diameter and not sufficiently stable. It was also found that when emulsified at a high temperature, the particle size of the emulsified particles was larger than that at room temperature. Also, good results were not obtained for the feeling of use.

On the other hand, Test Examples 1-10 to 1-12 using POP (4) POE (17) random copolymer dimethyl ether as an aqueous solvent have a sufficiently fine emulsion particle size and good stability, and are emulsified at high temperatures. Even so, the emulsified particle size was almost the same as at room temperature. Moreover, even if there was little surfactant with respect to an oil component, it was able to be set as the sufficiently fine particle diameter of 0.3 micrometer or less. Furthermore, good results were shown for the feeling of use.
In addition, as can be seen by comparing Test Examples 1-11 and 1-12, in this production method, when a higher alcohol or higher fatty acid that is liquid at room temperature such as isostearic acid is added to the oil, the emulsified particles become finer. As a result, not only was the stability improved, but also the oiliness when applied to the skin could be reduced.

Next, the oil particle size when emulsified at 70 ° C. and the stability of the obtained oil-in-water emulsion composition were examined for oil components containing semi-solid or solid at room temperature. Table 3 shows the results.

Production method (1) (B) Nonionic surfactant in Table 3 and (C) Oil component are mixed, and (A) Aqueous solvent is gradually added while applying to homomixer at 70 ° C., and oil-in-water emulsion composition in aqueous solvent Was prepared.
(2) This oil-in-water emulsion in an aqueous solvent was added to (D) the aqueous formulation to obtain an oil-in-water emulsion.
Measurement of the emulsified particle diameter of emulsion particle size resulting oil-in-water emulsion was carried out by a light scattering method. The apparatus used was FPAR-1000 (manufactured by Otsuka Electronics Co., Ltd.).

Stability The stability of the obtained oil-in-water emulsion composition was determined according to the following criteria after the composition was stored for 1 month under temperature test conditions of 0 ° C., room temperature, 37 ° C. and 50 ° C.
◎: No abnormality in appearance such as separation or change in transparency is observed at each test temperature. ○: Only a composition having a test temperature of 50 ° C. has a slight change in appearance. △: About a composition having a test temperature of 37 ° C. In addition, an abnormality such as a change in appearance is observed. ×: An abnormality such as a change in appearance is observed even for a composition having a test temperature of room temperature and 0 ° C. As can be seen from Table 3, emulsification by a conventional non-aqueous emulsification method. In Test Examples 2-5 to 2-8, it was not possible to obtain a sufficiently fine emulsified particle diameter with respect to a semi-solid or solid oil component at room temperature. On the other hand, in Test Examples 2-1 to 2-4 using the POP (4) POE (17) random copolymer as the aqueous solvent, it was possible to obtain a sufficiently fine emulsified particle size of 0.3 μm or less.

Next, the following test was conducted to investigate a suitable range for the ratio of POE to the sum of POP and POE in the POP / POE random copolymer dimethyl ether (POE / POP + POE).

Stability The stability of the obtained oil-in-water emulsion composition was determined according to the following criteria after the composition was stored for 1 month under temperature test conditions of 0 ° C., room temperature, 37 ° C. and 50 ° C.
◎: No abnormality in appearance such as separation or change in transparency is observed at each test temperature. ○: Only a composition having a test temperature of 50 ° C. has a slight change in appearance. △: About a composition having a test temperature of 37 ° C. In addition, an abnormality such as a change in appearance is observed. ×: An abnormality such as a change in appearance is also observed for a composition having a test temperature of room temperature and 0 ° C. From the results shown in Table 4, in particular, the number of moles of POP and POE added. It was found that the ratio of the added mole number of POE to the sum is particularly preferably 0.5 or more.
Examples according to the present invention will be specifically described below. In addition, the numerical value in prescription is the mass% with respect to the completed oil-in-water type composition. However, the present invention is not limited to the following.

<Lotion>
(Compounding ingredients)
(1) POE (25) Octyldodecanol 0.045
(2) Sorbitan sesquiisostearate 0.015
(3) Squalane 0.4
(4) Oleic acid 0.1
(5) Retinol palmitate 0.02
(6) Fragrance 0.01
(7) POP (07) POE (14) dimethyl ether (random copolymer) 0.4
(8) Ion exchange water 0.4
(9) Ethanol 6.0
(10) Dipropylene glycol 3.0
(11) 1,3-butylene glycol 6.0
(12) Polyethylene glycol 1500 2.0
(13) Betaine 1.0
(14) Citric acid 0.01
(15) Sodium citrate 0.09
(16) Sodium edetate 0.1
(17) Paraben 0.15
(18) Ion exchange water Residue (Production method)
(1)-(6) was mixed and the mixture of (7) and (8) was added, applying to a homomixer at normal temperature. The obtained oil-in-water emulsion in an aqueous solvent was added to the aqueous formulation part of (9) to (18), which was uniformly dissolved in advance.
The obtained lotion-like oil-in-water emulsion composition had an average particle size of 0.14 μm, good stability over time, and a fresh, non-sticky feel.

<Whitening lotion>
(Compounding ingredients)
(1) POE (30) phytosterol 0.045
(2) Sorbitan sesquiisostearate 0.015
(3) α-olefin oligomer 0.25
(4) Lauroyl glutamic acid (phytosteryl / octyldodecyl) 0.05
(5) Tetra (ethylhexanoic acid / benzoic acid / behenic acid) pentaerythrityl 0.05
(6) Hydroxy stearic acid hydrogenated castor oil 0.05
(7) Isostearic acid 0.1
(8) Fragrance 0.01
(9) POP (4) POE (17) dimethyl ether (random copolymer) 0.4
(10) Ion exchange water 0.5
(11) Ethanol 5.0
(12) 1,3-butylene glycol 3.0
(13) Erythritol 2.0
(14) Xylitol 0.5
(15) Trilaureth-4-phosphate 0.02
(16) Ascorbic acid glucoside 2.0
(17) Citric acid 0.02
(18) Sodium citrate 0.18
(19) Sodium edetate 0.1
(20) Potassium hydroxide 0.38
(21) Paraben 0.1
(22) Phenoxyethanol 0.2
(23) Ion exchange water Residue (Production method)
(1) to (8) were mixed, and the mixture of (9) and (10) was added while applying to a homomixer at 70 ° C. The obtained oil-in-water emulsion in an aqueous solvent was added to the aqueous formulations of (11) to (23), which were uniformly dissolved in advance.
The obtained lotion-like oil-in-water emulsion composition had an average particle size of 0.16 μm, good stability over time, and a fresh and non-sticky feel.

<Emulsion>
(1) Beheness-30 0.96
(2) Tri (ethylhexanoic acid) glyceride 2.0
(3) Squalane 2.0
(4) Dimethylpolysiloxane (6cs) 1.0
(5) Vaseline 2.0
(6) Deodorized polyisobutene 0.2
(7) Behenyl alcohol 0.5
(8) Batyl alcohol 0.1
(9) Phytosterol 0.02
(10) Tocopherol acetate 0.05
(11) Isostearyl alcohol 2.0
(12) POP (28) POE (55) dimethyl ether (random copolymer) 6.4
(13) Ion exchange water 8.0
(14) Glycerin 4.0
(15) 1,3-butylene glycol 5.0
(16) Methyl Gluces-10 0.5
(17) Yukinoshita extract 0.2
(18) Carbomer 0.1
(19) Xanthan gum 0.05
(20) Sodium edetate 0.03
(21) Paraben 0.3
(22) Potassium hydroxide 0.02
(23) Ion exchange water Residue (Production method)
(1) to (11) were mixed, and the mixture of (12) and (13) was added while applying to a homomixer at 70 ° C. The obtained oil-in-water emulsion in an aqueous solvent was added to the aqueous formulations of (14) to (21) and (23) which were uniformly mixed in advance. (22) was added to neutralize.
The obtained emulsion oil-in-water emulsion composition had an average particle size of 0.25 μm, good stability over time, and excellent skin moisturizing and softening effects.

<Sunscreen>
(1) POE (30) Phytosterol 1.0
(2) POE (30) octyldodecanol 0.4
(3) Sorbitan sesquiisostearate 0.5
(4) Octyl methoxycinnamate 5.0
(5) Cetylisooctanoic acid 5.0
(6) 4-t-butyl-4'-methoxydibenzoylmethane 0.8
(7) Octocrylene 1.5
(8) Isostearic acid 1.0
(9) Isostearyl alcohol 1.0
(10) Octyldodecanol 0.5
(11) Perfume 0.03
(12) POP (28) POE (55) dimethyl ether (random copolymer) 12.9
(13) Ion exchange water 9.0
(14) Ethanol 7.0
(15) Dipropylene glycol 5.0
(16) Phenylbenzimidazolesulfonic acid 3.0
(17) Citric acid 0.01
(18) Sodium citrate 0.04
(19) Sodium edetate 0.05
(20) Phenoxyethanol 0.5
(21) Sodium hydroxide 0.45
(22) Residual ion exchange water (Production method)
(1) to (11) were mixed, and the mixture of (12) and (13) was added while applying to a homomixer at 70 ° C. The obtained oil-in-water emulsion in an aqueous solvent was added to the aqueous formulations of (14) to (22), which were uniformly dissolved in advance.
The obtained lotion-shaped sunscreen had an average particle size of 0.18 μm and good stability over time. Since the oily component containing the ultraviolet absorber is miniaturized, it does not become uneven when applied to the skin, and exhibits a high ultraviolet protection effect.

<Hair mist>
(1) POE (30) phytosterol 0.05
(2) Polyoxyethylene / methylpolysiloxane copolymer 0.01
(3) Methyl polysiloxane (6cs) 0.4
(4) Methyl polysiloxane (20 cs) 0.2
(5) Methylphenylpolysiloxane 0.2
(6) Isostearic acid 0.2
(7) Fragrance 0.05
(8) Tocopherol 0.01
(9) POP (4) POE (17) dimethyl ether (random copolymer) 0.4
(10) Ion exchange water 0.4
(11) 1,3-butylene glycol 7.0
(12) Glycerin 4.0
(13) Phenoxyethanol 0.5
(14) Behenyltrimethylammonium chloride 0.2
(15) Ethanol 3.0
(16) Residual ion exchange water (Production method)
(1) to (8) were mixed, and the mixture of (9) and (10) was added while applying to a homomixer at 70 ° C. The obtained oil-in-water emulsion in an aqueous solvent was added to the aqueous formulation parts (11) to (14) and (16) which were uniformly dissolved in advance at 70 ° C. and stirred. After cooling to room temperature, (15) was added.
The obtained skin lotion-like hair mist had an average particle size of 0.15 μm and good stability over time. When applied to the hair, it was non-sticky and stretched well, and after drying it had a great effect of smoothing the hair.

Schematic diagram illustrating the production method according to the present invention

Explanation of symbols

10 High Concentration Aqueous Solvent Solution 12 Oil 14 Nonionic Surfactant 16 Nonionic Surfactant Hydrophilic Group 18 POPPOE Dialkyl Ether Molecules

Claims (7)

  (A) an aqueous solvent, (B) a nonionic surfactant, and (C) an oil component are mixed and stirred to prepare an oil-in-water emulsion composition in an aqueous solvent; A step of adding an aqueous formulation to prepare an oil-in-water emulsion composition, wherein (A) the aqueous solvent contains a polyoxypropylene / polyoxyethylene random copolymer dialkyl ether in water A method for producing an oil-type fine emulsion composition. In the manufacturing method of Claim 1,
A method for producing an oil-in-water fine emulsion composition, wherein the preparation is carried out at a temperature of 70 ° C. or higher in at least the oil emulsion composition preparation step in the aqueous solvent. In the manufacturing method of Claim 1 or 2,
(C) A method for producing an oil-in-water microemulsion composition, which comprises a solid or semi-solid oil at room temperature as the oil. In the manufacturing method in any one of Claim 1 to 3,
The method for producing an oil-in-water fine emulsion composition, wherein the amount of the oil component (C) is 5 times or more with respect to the amount of the (B) nonionic surfactant. In the manufacturing method in any one of Claim 1 to 4,
The method for producing an oil-in-water fine emulsion composition, wherein the oil-in-water fine emulsion composition has an emulsified particle diameter of 0.3 μm or less. In the manufacturing method in any one of Claim 1 to 5,
(A) The manufacturing method of the oil-in-water type fine emulsion composition characterized by including the polyoxyethylene polyoxypropylene random copolymer dimethyl ether in the aqueous solvent. In the manufacturing method in any one of Claim 1 to 6,
(C) The method for producing an oil-in-water fine emulsion composition, wherein the oil component contains one or more higher alcohols or higher fatty acids that are liquid at room temperature.

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