JP2007014594A - Chemicals feeder - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a chemicals feeder convenient in its operation, which prevents injection pain and gives no injection fear. <P>SOLUTION: The chemicals feeder includes a chemical chamber to contain a chemical therein, and a needle of a needle keeper, which communicate so as to discharge the chemical out of a needlepoint. A circular outer frame surrounding the chemical chamber and a circular plate made of an elastic material are coupled to be cushion-like, which enables a strong slap on a surface of the circular outer frame and a part of a body together to discharge the chemical, and to prevent the injection pain by the feeder. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a chemical solution injection device, and more specifically, closes the device to a skin surface which is a chemical solution injection site of the body, and by strongly slap the skin surface together with the device, the chemical solution is injected into the body, and a part of the body The present invention relates to a drug solution injection device that does not feel pain due to an injection needle due to a strong stimulus felt by slap.

  Since injection is accompanied by unpleasant irritation, it is a depressing event for those who receive it. In particular, in the case of injection therapy that requires daily administration, frequent administration, and long-term administration, pain due to the needle, fear of injection, depression, annoyance, time required for treatment, etc. are major problems. Even now that the method of using a simple cartridge with a thin injection needle is being carried out, it can be said that the physical and mental distress is great.

  Therefore, if the self-injection can be performed without danger without feeling the pain of the injection needle and the fear of injection, and without causing the unpleasant feeling of drug injection, the burden on the patient is remarkably reduced, for example, insulin injection treatment is performed. In addition to making significant contributions to medical care such as diabetes, social contributions such as reducing medical expenses are significant.

  Accordingly, an object of the present invention is to provide a medicinal solution injection device that does not feel pain due to injection, does not feel fear of injection, and is easy to operate.

  In order to solve this problem, the present inventor has conducted intensive studies, and as a result, the medicinal solution injecting device is brought into close contact with the skin surface, which is the injecting site (administration site) of the medicinal solution in the body, and the skin surface including the medicinal device is slapped. (Slap; forcefully slap a part of the body with a slack) to easily inject the drug solution subcutaneously or intramuscularly, and at the same time, a drug solution injection device that does not cause severe pain due to the puncture of the injection needle The headline and the present invention were completed.

  Therefore, the present invention provides a chemical solution injection device that does not feel pain (hereinafter referred to as “needle pain”) due to puncture of an injection needle and can inject (administer) a target chemical solution with a simple operation.

More specifically, the present invention has the following basic configuration as an aspect thereof.
(1) a liquid medicine injection part formed by sealing a lower part of a cylindrical chemical liquid chamber with a bottom provided with a needle support that holds a needle communicating with the chemical liquid chamber;
A circular outer frame that is joined to the upper surface of the chemical solution chamber and surrounds the chemical solution injection portion, with a lower portion opened,
An elastic material disk serving as a skin contact surface with a portion fitted to the circular outer frame;
Consists of
A chemical liquid injector, wherein a needle support of the chemical liquid injector and a tip portion of a needle held by the needle support are embedded in an elastic material disk;
(2) When an elastic material disk serving as a skin contact surface of the chemical liquid injector is brought into close contact with the skin surface and the upper part of the circular outer frame is strongly slapd together with a part of the body (hereinafter referred to as “slap”), The liquid injector according to (1) above, wherein a needle tip held by a needle support embedded in the plate is exposed to 1 to 4 mm to the outside of the elastic material disk;
(3) The above-mentioned (1), wherein the needle tip exposed to the outside of the elastic disk is instantaneously returned into the elastic disk when the hand force is removed after the upper part of the circular outer frame is slapd. A chemical injection device according to claim 1;
(4) The chemical injection device according to (1) above, wherein a ring through which a finger can pass is attached to the upper part of the circular outer frame;
(5) The chemical injection device according to (1), wherein the volume of the chemical chamber is 10 to 120 μL;
(6) The chemical injection device according to (1), wherein the volume of the chemical chamber is 50 to 11 μL;
(7) The chemical injection device according to (1) above, wherein the bottom area of the elastic material disk is 1 to 10 cm ² ;
(8) The chemical injection device according to (1), wherein the elastic material disk has a bottom area of ² to 5 cm ² ;
(9) The liquid injector according to (1) above, wherein the needle held by the needle support is an injection needle having an outer diameter of 0.1 to 0.5 mm and a length of 2 to 6 mm;
(10) The chemical injection device according to (1), wherein the elastic material disk is an elastic material made of sponge, rubber, or latex;
It is.

Furthermore, the present invention provides
(11) The medicinal solution injection device according to (1), wherein the medicinal solution incorporated in the medicinal solution chamber is an injection solution or suspension of a drug or vaccine that requires frequent injection administration and is effective in a small amount ;
(12) Drug is insulin, human growth hormone, interferon-α, interferon-β, interferon-γ, erythropoietin, thrombopoietin, urokinase, t-PA, interleukins, G-CSF, GM-CSF, SOD, FGF, EGF A medicinal solution injecting device according to (11) above, which is selected from HGF, NGF, BDNF, leptin, NT-3, PTH, ACTH, GnRH, TRH, vasopressin, calcitonin, midkine, antigen, antibody and enzyme;
(13) The drug solution injector according to (11) above, wherein the drug is a nanoparticulate or microparticulate product of the drug described in (12) above;
(14) The chemical solution injection device according to (1), which is used for injection into the skin or muscle;
It is.

Moreover, this invention is another aspect,
(15) The chemical solution injection device described in any one of (1) to (14) is brought into close contact with the skin surface, and the upper surface of the circular outer frame of the device and the vicinity of the skin where the chemical solution injection device is in close contact with each other are strongly slapd simultaneously. A chemical solution injection method characterized by injecting a chemical solution built in the chemical solution chamber;
It is.

  As described above, according to the present invention, the drug solution is instantly injected subcutaneously and intramuscularly by slap (strong slap) on the skin surface as a drug injection site, and does not feel needle pain due to stimulation by the slap. It is extremely specific in that it provides an injection device and a chemical solution injection method using the device.

The chemical injection device and the chemical injection method provided by the present invention slap the skin contact surface of the chemical injection device together with injection sites such as the thigh and lower leg, upper arm, forearm, and abdomen, that is, strongly slap. Thus, the drug solution is instantaneously injected and the needle is instantaneously removed, and there is an advantage that the pain due to needle puncture and the discomfort of the drug solution injection are not felt.
This is thought to be because needle pain is concealed and alleviated by strong slap stimulation to a part of the body such as the thigh and lower leg. In addition, since the needle of the injection device cannot be seen from the outside, there is an advantage that almost no fear of injection is felt.
Further, since the drug injection treatment can be performed simply by slap the drug injection device, it is simple and has the advantage that the administration of the drug solution can be completed within one minute.

The chemical injection device of the present invention has a bottom area of the device itself of about 1 to 10 cm ² and a height of about 1.3 to 3.0 cm. Even in public, it has the feature that self-administration can be easily performed especially in the forearm. In addition, since this apparatus is small and light, for example, when the drug is insulin, it has an advantage that it can be carried in a pocket, a bag, etc. for one day.

  Furthermore, the chemical solution chamber is accommodated so that a certain amount of chemical solution exhibiting a desired therapeutic effect can be administered by one slap operation, and no further chemical solution is injected. Therefore, it has high safety, and can be disposable as a disposable type, and is hygienic and has an advantage that there is no fear of infection to others.

  Moreover, in the chemical solution injection device of the present invention, since the filling of the chemical solution is a predetermined amount per administration, several types of devices having different chemical solution contents can be prepared. For example, when the drug is insulin, there is an advantage that the dose is not mistaken if the product is made into 3, 5, 8, 10, 15 units and the products are color-coded.

  As the drug used in the drug solution injector of the present invention, a drug that requires frequent injections and that exhibits an effect in a very small amount is particularly effective.

  As described above, the drug solution injection device of the present invention changes the concept of conventional injections, and is a drug solution administration device that greatly contributes to diabetes treatment and the like.

As described above, the chemical injection device provided by the present invention is basically
A medicinal solution injecting portion formed by sealing the lower portion of the cylindrical medicinal solution chamber with a bottom portion provided with a needle support for holding a needle communicating with the medicinal solution chamber;
A circular outer frame that is joined to the upper surface of the chemical solution chamber and surrounds the chemical solution injection portion, with a lower portion opened,
An elastic material disk serving as a skin contact surface with a portion fitted to the circular outer frame;
Consists of
In the chemical liquid injector, the needle support of the chemical liquid injector and the tip of the needle held by the needle support are embedded in an elastic material disk.

Hereinafter, a chemical liquid injector provided by the present invention will be described in detail with reference to the drawings.
FIG. 1 is an enlarged cross-sectional view schematically showing a chemical injection device according to one embodiment of the chemical injection device of the present invention.

  In the figure, reference numeral 1 denotes a chemical solution injection device according to the present invention. The chemical solution injection device 1 is provided with a needle support 13 for holding a needle 12 communicating with the chemical solution chamber 11 at a lower portion of the chemical solution chamber 11 provided in the cylinder 10. A liquid injection part 20 sealed by the bottom 14, a circular outer frame 30 which is bonded to the upper surface of the chemical liquid chamber 11 and whose lower part surrounding the chemical injection part 20 is released, and a skin contact surface 45 which contacts the skin. The elastic material disk 40 is partly fitted in the circular outer frame 30 and is held by the needle support 13 of the drug solution injector 20 and the needle support. A configuration is adopted in which the tip portion 15 of the needle 12 is embedded in an elastic material disk.

  That is, the chemical injection device 1 of the present invention employs a configuration in which a chemical injection unit 20 including a chemical solution chamber 11 and a needle support 13 that holds a needle 12 communicating with the chemical solution chamber is surrounded by a circular outer frame 30. Then, a part of the elastic material disk 40 is fitted to the circular outer frame 30 and the needle support 13 of the drug solution injection part 20 and the tip portion 15 of the needle 12 held by the needle support are made of an elastic material circle. Uses a structure embedded in the plate.

  In this case, the bottom surface of the elastic material disk 40 is flat in order to bring the device of the present invention into close contact with the skin surface of the body where the liquid medicine is injected, such as the thigh, lower leg, upper arm, forearm, and abdomen. A skin contact surface 45 is provided.

  Therefore, when a chemical solution is administered using the chemical solution injection device 1 of the present invention, the chemical solution injection device 1 is brought into close contact with the skin contact surface 45, which is the bottom surface of the elastic material disk 40, in the state where the injection is performed. The elastic material circle includes the upper surface 31 of the circular outer frame 30 and slaps the administration site, or holds and fixes the liquid injector of the present invention in the palm and slaps the injection site of the body in that state. The plate 40 is in a cushioned state due to its elasticity, and the needle 12 is exposed to the outside. Therefore, the needle 12 is pierced into the injection site of the body in contact with the skin contact surface 45, and the liquid medicine is instantaneously injected into the body.

  Since this slap operation is performed instantaneously, only the strong stimulation by the slap is given in the vicinity of the injection site, and as a result, the total amount of the chemical solution in the chemical solution chamber is hardly felt. Will be administered at the site of injection.

  A schematic enlarged cross-sectional view of the scrap-operated chemical liquid injector of the present invention is shown in FIG. In addition, the code | symbol in a figure is the same as that of FIG.

  In the state where the chemical liquid injection device of the present invention, which has been administered with the chemical liquid by the scrap operation, is separated from the skin surface, the circular outer frame 30 returns to the original state by the repulsive elastic force of the elastic material disk 40, and as a result The needle that has been punctured into the elastic body disk is buried in the elastic material disk 40 at the same time as it escapes from the injection site of the body. Therefore, the used device can be discarded in that state.

  That is, when disposing of the chemical injection device of the present invention after use, since the tip of the dangerous needle is not exposed to the outside, it is possible to perform extremely safe disposal, and to prevent blood infection to others. There is no danger.

  In FIG. 3, the whole external appearance schematic diagram of the chemical | medical solution injection | pouring apparatus of this invention was shown. In addition, the ring 32 is attached to the upper part of the circular outer frame 30 in the figure, which is convenient for daily carrying. Further, by passing a finger through the ring 32, the liquid medicine injection device of the present invention can be held and fixed to the palm, and the slap operation in that state can be easily performed. Furthermore, the ring 32 can be appropriately color-coded to serve as an index for the dose in the drug solution. For example, when the drug is insulin, the dose is not mistaken if each product of 3, 5, 8, 10, 15 units is distinguished by appropriately color-coding the ring 32.

  In the liquid injector 1 of the present invention, the needle 12 embedded in the elastic material disk 40 is exposed from the elastic material disk 40 subcutaneously or when the upper surface 31 of the circular outer frame 30 is slapd. It is necessary to expose the distal end portion 15 of the needle necessary for piercing into the muscle, and specifically, it is preferably designed to be exposed from the elastic material disk of 1 to 4 mm.

  In addition, when the drug solution injection device of the present invention is slapd, the total amount of the drug solution built in the drug solution chamber 11 needs to be discharged through the needle 12 and administered to the injection site of the body. The volume of 11 is 10 to 200 μL, preferably 50 to 100 μL. In addition, the capacity | capacitance can be suitably selected with the injection amount of 1 time of the chemical | medical solution to be used.

  In the chemical solution injector of the present invention, the needle support 13 is integrated with the bottom surface of the chemical solution chamber 11, and is communicated so that the chemical solution contained in the chemical solution chamber passes through the opening of the needle. The needle held by the needle support body needs to be instantaneously released and administered when the chemical liquid contained in the chemical liquid chamber 11 slaps, so that the outer diameter is 0.1 to 0.5 mm and the length is 2 It is preferred to use an injection needle with a size of ˜6 mm.

  Further, in the chemical injection device 1 of the present invention, in order to integrate the chemical injection unit 20 and the circular outer frame 30, the upper surface of the chemical solution chamber 11 is integrally joined to the circular outer frame 30, and the chemical injection unit 20 is entirely stored in a circular outer frame 30. Further, by providing the ring 32 through which a finger can pass on the outer upper surface of the circular outer frame, it is possible to easily slap, and it is possible to easily remove the needle from the injection site when slapd.

  The chemical solution injection device provided by the present invention is the most effective in injecting a chemical solution instantaneously without slap pain by using the elasticity of the elastic material disk 40 fitted to the circular outer frame 30. It is a feature. Since the slap is instantaneous and due to the strong stimulation in the vicinity of the device that the slap gives, the needle pain is concealed and alleviated.

  The elastic material as the elastic material disk 40 may be any material as long as the exposed needle 12 returns to the elastic material disk instantaneously when the circular outer frame 30 is slapd. , Rubber, latex and the like, among which sponge is preferably used.

Further, the bottom area of the elastic material disc 40 is coincident with the release area of the base of the circular outer frame 30, 1 to 10 cm ^2, and it is preferably a 2 to 5 cm ^2. The bottom surface of the elastic material disk 40 is in contact with injection sites such as the thigh, lower leg, upper arm, forearm, and abdomen, so a flat skin contact surface 45 is provided.

  The material of the circular outer frame 30 may be any material as long as it fits snugly with the elastic material disk 40 and does not impair the elasticity of the elastic material disk 40. In order to prevent misuse after using the chemical injection device of the present invention, the outer frame is preferably transparent so that the inside of the device can be seen from the outside. The length from the upper surface of the circular outer frame 30 to the skin contact surface 45 of the elastic material disk 40 is preferably about 1.3 to 3.0 cm.

  As a drug that can be used in the drug solution injection device of the present invention, there is a drug that has a simple operation method and requires a small amount of administration, and therefore requires frequent injection administration, and exhibits a small amount of an effect. Is suitable. These drugs are used as solutions or suspensions.

  Preferred drugs include insulin, human growth hormone, interferon-α, interferon-β, interferon-γ, erythropoietin, thrombopoietin, urokinase, t-PA, interleukins, G-CSF, GM-CSF, SOD, FGF, EGF , HGF, NGF, BDNF, leptin, NT-3, PTH, ACTH, GnRH, TRH, vasopressin, calcitonin, midkine, antigens, antibodies and enzymes, and vaccines.

  In addition, nanoparticulates or microparticulates of these drugs can also be used. As nanoparticulates, WO2005-023282 discloses protein and peptide nanoparticles. As microparticulates, WO2004-112751 discloses interferon microparticles, and JP2005-8545 discloses human growth hormone. Of microparticles are described.

  The drug solution injection device of the present invention can be used for subcutaneous injection and intramuscular injection, but is particularly excellent in subcutaneous injection because the length of the exposed portion of the needle to the outside when the slap is 1 to 4 mm.

  The drug solution injection device of the present invention can be used not only for injecting a drug solution subcutaneously or intramuscularly but also for collecting blood for measuring blood components. For example, a small amount of bleeding may be caused from the skin by slap the device with a cotton needle instead of the injection needle of the device on the skin, and the bleeding blood may be used for measurement of blood components such as insulin. Is possible.

It should be noted that the chemical solution injection device provided by the present invention can be variously modified without departing from the object thereof, and such variations are also included in the technical scope of the present invention.
Furthermore, the present invention also provides a method for injecting a chemical solution using the chemical solution injection apparatus described above, and the means thereof can be easily understood from the above description.

  Specific examples in which the chemical injection device of the present invention is actually used and effects thereof will be shown below, but the present invention is not limited to these.

Example 1: Subcutaneous injection by slap Actually using a syringe needle having an outer diameter of 0.25 mm and a length of 2.5 mm, a drug solution injection device similar to that shown in FIG. 1 is prepared by filling a drug solution chamber with 50 μL of physiological saline. The entire apparatus was sterilized. Next, for the three volunteers who agreed, put the middle finger through the ring attached to the upper surface of the outer frame of the device, put the device on the palm, and hit the volunteer's thigh strongly (slap). At the same time, the device moved away from the thigh. As a result, all three volunteers felt almost no pain due to the thigh needle, and the entire amount of 50 μL of physiological saline was injected subcutaneously into the thigh.

Example 2 Effect of Subcutaneous Injection of Insulin The side of the waist of 2 kg rabbits (2 heads) fasted for 16 hours was shaved with a clipper and slapd at that site in the same manner as in Example 1. However, 50 μL of the drug solution was obtained by diluting 2 units of regular insulin with physiological saline. Blood was collected at 0, 10, 30, 60, and 120 minutes after the ear vein, and the insulin level was measured by ELISA. Two days later, using the same rabbit, the same amount of insulin was usually injected subcutaneously into the same site on the opposite side, and the blood insulin concentration was measured at the same interval. The results are shown in FIG. 4 and showed almost the same insulin concentration curve.

  From the above, it was found that the same amount of insulin as in the subcutaneous injection that is normally performed is injected by the drug solution injection device of the present invention and distributed in the body.

As described above, the medicinal solution injecting device of the present invention has the advantages that it can be infused instantaneously without feeling a needle pain, is portable, and can be safely infused without variation in dosage.
Therefore, it is a chemical solution injection device and method that changes the concept of conventional injections, and is an administration device and method that greatly contributes to diabetes treatment and the like.

It is the cross-sectional enlarged view which showed typically the apparatus based on the one Example about the chemical | medical solution injection device of this invention. It is the cross-sectional enlarged view which showed typically the case where a chemical | medical solution is administered using the chemical | medical solution injection device of this invention. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an overall view of an apparatus according to an embodiment of a chemical liquid injector of the present invention. 10 is a graph showing the results of Example 2.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Chemical solution injection device 11 Chemical solution chamber 12 Needle 13 Needle support body 20 Chemical solution injection part 30 Circular outer frame 40 Elastic material disk 45 Skin contact surface

Claims (15)

A medicinal solution injecting portion formed by sealing the lower portion of the cylindrical medicinal solution chamber with a bottom portion provided with a needle support for holding a needle communicating with the medicinal solution chamber;
A circular outer frame that is joined to the upper surface of the chemical solution chamber and surrounds the chemical solution injection portion, with a lower portion opened,
An elastic material disk serving as a skin contact surface with a portion fitted to the circular outer frame;
Consists of
A drug solution injection device, wherein a needle support of the drug solution injection section and a tip portion of a needle held by the needle support are embedded in an elastic material disk.   When the elastic material disk serving as the skin contact surface of the chemical injection device is in close contact with the skin surface and the upper part of the circular outer frame is strongly slapd together with a part of the body (hereinafter referred to as “slap”), The liquid injector according to claim 1, wherein a needle tip held by an embedded needle support is exposed to 1 to 4 mm to the outside of the elastic material disk.   2. The chemical solution according to claim 1, wherein when the hand is pulled after the upper part of the circular outer frame is slapd, the tip of the needle exposed to the outside of the elastic material disk instantaneously returns into the elastic material disk. Injection device.   The chemical injection device according to claim 1, wherein a ring through which a finger can pass is attached to an upper portion of the circular outer frame.   The chemical solution injector according to claim 1, wherein the chemical chamber has a volume of 10 to 200 µL.   The chemical solution injection device according to claim 1, wherein the chemical solution chamber has a volume of 50 to 100 μL. Liquid injector according to claim 1, bottom area of the elastic material disk is 1 to 10 cm ^2. The chemical injection device according to claim 1, wherein the elastic material disk has a bottom area of ² to 5 cm ² .   The drug solution injector according to claim 1, wherein the needle held by the needle support is an injection needle having an outer diameter of 0.1 to 0.5 mm and a length of 2 to 6 mm.   The chemical injection device according to claim 1, wherein the elastic material disk is an elastic material made of sponge, rubber or latex.   The medicinal solution injection device according to claim 1, wherein the medicinal solution incorporated in the medicinal solution chamber is an injection solution or suspension of a drug or vaccine that requires frequent injection administration and is effective in a very small amount.   The drug is insulin, human growth hormone, interferon-α, interferon-β, interferon-γ, erythropoietin, thrombopoietin, urokinase, t-PA, interleukins, G-CSF, GM-CSF, SOD, FGF, EGF, HGF, The medicinal solution injection device according to claim 11, which is selected from NGF, BDNF, leptin, NT-3, PTH, ACTH, GnRH, TRH, vasopressin, calcitonin, midkine, antigen, antibody and enzyme.   The drug solution injection device according to claim 11, wherein the drug is a nanoparticulate or microparticulate product of the drug described in claim 12.   The medicinal-solution injecting device according to claim 1, which is used for injecting subcutaneously or intramuscularly. A chemical solution injection device according to any one of claims 1 to 14 is brought into close contact with the skin surface, and the upper surface of the circular outer frame of the device and the vicinity of the skin where the chemical solution injection device is closely attached are simultaneously strongly slapd into the chemical solution chamber. A method of injecting a chemical solution, characterized by injecting a built-in chemical solution.

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