JP2006326368A - Transfer needle - Google Patents

Abstract

[PROBLEMS] To provide a safe and easy and reliable dissolution preparation of a drug in a liquid such as a solution or a chemical solution with a simple structure.
A liquid member 1 and a liquid member 1 are connected to or connected to the liquid member 1 so as to be separable in a liquid-tight state, and the liquid member 1 is defined as a drug member 2 side. The liquid hollow needle 6 protrudes on the opposite side, and the drug member 2 has a drug hollow needle 19 protruding on the opposite side of the liquid member 1 and communicating with the liquid hollow needle 6. A female luer in which at least one of the member 1 and the medicinal member 2 is opposed to the other and communicates with the one hollow needle 6, 19 and the syringe needle connecting portion is detachably connected in a liquid-tight state. 23 is provided.
[Selection] Figure 2

Description

  The present invention relates to a transfer needle, and more specifically, when a drug is dissolved and prepared in a liquid such as a solution or a drug solution during the preparation of an infusion solution, the solution or drug solution is transferred from the container to the drug-containing container. The present invention also relates to a transfer needle that is safe and can be injected easily and reliably.

  Preparations that are chemically unstable, such as antibiotics, anticancer drugs, blood products, and the like that change in the state of infusion, are usually stored in a lyophilized state in vials sealed with rubber stoppers. Immediately before, the preparation is used by dissolving and preparing it in a solution such as distilled water, physiological saline or glucose solution.

  At the time of this dissolution preparation, conventionally, using a metal hollow needle and a syringe, the solution is sucked from the container containing the solution, then injected into the container containing the drug, the drug is dissolved in the solution, and a drug solution is prepared. The most common method is to return the prepared drug solution to the syringe. However, this method is not only complicated, but also involves a risk of erroneous piercing by a metal hollow needle. Therefore, various transfer needles have been proposed in which dissolution preparation can be performed safely and easily and reliably (see, for example, Patent Documents 1 to 3).

  However, there are the following problems as problems of the conventional transfer needle. That is, the transfer needle is generally formed by injection molding, but there are also the following problems. That is, for example, as shown in FIG. 38, the transfer needle 77 includes a substrate 78, an upper hollow needle 79 projecting upward from the substrate 78, and a lower hollow projecting downward from the substrate 78 and communicating with the upper hollow needle 79. A needle 80, a skirt 81 standing from the outer peripheral edge of the substrate 78, a skirt 82 extending from the outer peripheral edge of the substrate 78, and the like. When manufacturing such a transfer needle 77 by injection molding, for example, upper and lower molds 83 and 84 as shown in FIG. 39 are used, and the mold 84 is inserted into the insertion hole 83A of the mold 83. It is conceivable that the insertion portion 84A to be inserted is formed, and the upper hollow needle 79 is formed between the insertion hole 83A and the insertion portion 84A.

  However, in this case, the length of the portion of the mold 84 that is located inside the lower hollow needle 79 and the insertion portion 84A (this portion is supported by the mold 84 only at the lower end). The length L becomes extremely long, causing a problem in its strength. Therefore, in practice, molds 83 and 84 as shown in FIG. 40 are used.

  As described above, the conventional integrated transfer needle needs to be formed by abutting the small-diameter liquid hollow needle 79 and the drug hollow needle 80 together. Therefore, if the molds 83 and 84 are strongly clamped at the time of molding, the molds 83 and 84 may be damaged. Conversely, if the molds 83 and 84 are weakly clamped, burrs are generated between the molds 83 and 84, and the communication state between the liquid hollow needle 79 and the drug hollow needle 80 becomes poor. appear. As described above, conventionally, it is difficult to adjust the clamping of the molds 83 and 84, and there is a problem that the transfer needle 77 cannot be easily formed.

  Further, the molds 83 and 84 are respectively formed with ring-shaped holes 83B and 84B for forming the wall portions of the hollow needles 79 and 80 that are elongated in the vertical direction. In this case, if the ring-shaped holes 83B and 84B have a small diameter, it is difficult to form the holes, and it is further difficult to make the insertion hole 83A and the insertion portion 84A thinner, and a high technique is required. Therefore, considering the molding stability of the transfer needle 77, the ring-shaped holes 83B, 84B inevitably have a large diameter, and as a result, the hollow needles 79, 80 have a large diameter.

  By the way, as shown in FIGS. 41A to 41C, when the hollow needle 71 of the transfer needle is punctured into the rubber stopper 72 of the vial 70, the hollow needle 71 is pushed back by the elastic force of the rubber stopper 72. Phenomenon, that is, a kickback phenomenon occurs. However, as described above, when the hollow needle 71 has a large diameter, the force pushed back when the hollow needle 71 is punctured into the rubber stopper 72 is large, and thereby communication between the hollow needle 71 and the inside of the vial 70 is achieved. There is a high possibility that the hollow needle 71 is disconnected from the rubber plug 72.

  As shown in FIGS. 37A to 37C, when the metal hollow needle 71 of the transfer needle is inserted into the rubber stopper 72 of the vial, first, the cutting edge 73 having a sharp cutting edge is first formed. Is inserted into the rubber plug 72 so as to cut the rubber plug 72, and then the rear side portion thereof is sequentially inserted into the rubber plug 72. At this time, since the rear end portion of the opening edge of the blade edge 73 of the hollow needle 71, that is, the heel portion 74 is sharp, the rubber plug 72 is likely to be cut off (coring) by the heel portion 74, Thereby, there was a possibility that the rubber piece 75 would be mixed into the prepared chemical solution. Similarly, coring occurs even in a large-diameter molded product.

  Further, conventionally, when a drug solution is prepared in a vial using a transfer needle, and the prepared drug solution in the vial is further moved to a syringe, the hollow needle of the transfer needle is attached to the vial. After removing from the rubber stopper, it was necessary to puncture the rubber stopper again with a metal hollow needle connected to the syringe and suck it into the syringe. For this reason, there is also a problem of occurrence of coring due to the needle piercing the rubber stopper twice.

  In order to solve this problem, the hollow needles of the transfer needles were inserted into the rubber stoppers of the upper and lower vials, and the solution and the drug in both vials were mixed to prepare the drug solution. When the upper vial is pulled away from the lower vial, the tip of the upper hollow needle is separated from the main body side of the transfer needle, and the tip of the lower hollow needle also falls into the lower vial. A technique has been proposed in which a prepared drug solution in the lower vial can be taken out by a syringe through the main body side of the transfer needle (see, for example, Patent Document 4). However, in this case, since the tip of each hollow needle remains in each vial, the work of separating and discarding the tip of each hollow needle and each vial is troublesome, and the needle piercing with the tip of each hollow needle, etc. Since there is a high possibility of causing an accident, practical application was difficult.

Japanese Utility Model Publication No. 56-9464 Japanese Patent Publication No.54-16152 Japanese Utility Model Publication No. 49-47507 Japanese Utility Model Publication No. 63-114649

  The problems to be solved are that a drug cannot be dissolved and prepared safely and easily and reliably in a liquid such as a solution or a chemical solution without causing any other problems, and the mold production and molding are It is not easy.

As a result of intensive studies to solve the above problems, the present inventors have conceived a transfer needle according to the present invention that can solve all the above problems.
The features of the present invention are as follows. A liquid member; The liquid member has a drug member that is separably connected to or connected to the liquid member. The liquid member has a liquid hollow needle that protrudes on the opposite side of the drug member side. The member for use is in a point having a hollow needle for medicine that protrudes on the opposite side to the member for liquid and communicates with the hollow needle for liquid.
At least one of the liquid member and the medicinal member has a female luer that communicates with the one hollow needle and is connected to the syringe needle connection portion in a liquid-tight manner so as to be separable in a portion facing the other. Sometimes provided.
Further, the liquid member and the drug member may be connected by the engaging means.
Further, a liquid hollow needle is provided with A.I. A liquid path communicating with the hollow drug needle; An air passage may be provided, and the liquid member may have a communication passage that communicates the air passage with the outside.
In addition, a filter may be provided in the communication path.
Further, the hollow needle for liquid and / or the hollow needle for medicine is A. A base having a cylindrical shape; It may have a sharp tip and an opening may be formed in the base.
In addition, a liquid hollow needle and / or a drug hollow needle may be formed as follows. A base having a cylindrical shape; It may have a sharpened tip and an opening may be formed in the tip.
In addition, a female luer may be provided with a filter.
In addition, the liquid member is provided with a guide that protrudes on the opposite side of the drug member and has a hollow needle for the liquid, and the drug member protrudes on the opposite side of the liquid member and has the hollow drug needle inside. In some cases, a guide is provided.
Further, the liquid member and the drug member may be connected by a flexible and breakable hinge.
In addition, the liquid member and the drug member may be detachably engaged, and a means for preventing the release of the engagement may be provided.
Furthermore, A.I. A liquid member; The liquid member has a liquid member that is integrated with the liquid member, the liquid member has a liquid hollow needle protruding to the opposite side of the liquid member side, and the liquid member is opposite to the liquid member The medicine hollow needle protrudes to the side and communicates with the liquid hollow needle, and an insertion hole that opens to the side is formed between the liquid hollow needle and the medicine hollow needle. An insert for communication may be inserted.
In addition, the liquid hollow needle and / or the drug hollow needle may have two openings at the tip.
Further, an air passage communicating with the liquid hollow needle is formed, and a filter may be provided in the air passage.
Further, the insert may be integrated via a hinge.

According to the transfer needle of the present invention, preparation of dissolution of a drug in a solution or a drug solution can be easily and reliably performed.
Moreover, since the transfer needle is a divided type having a liquid member having a liquid hollow needle and a drug member having a drug hollow needle, each hollow needle having a small diameter can be easily formed. Therefore, when each hollow needle is punctured into the rubber stopper of the vial, the phenomenon that the hollow needle is pushed back by the elastic force of the rubber stopper, that is, the kickback phenomenon can be suppressed, and each hollow needle is pushed from the rubber stopper. The return force can be reduced, and thereby the communication between each hollow needle and the inside of the vial can be cut off, the possibility that each hollow needle will accidentally come out of the rubber stopper can be reduced, and coring can also be suppressed.
Furthermore, as described above, since the transfer needle is a divided type having a liquid member having a liquid hollow needle and a drug member having a drug hollow needle, the hollow needle is not a tip but a shaft. A so-called “side hole needle” type having an opening in the middle in the center direction can be used, and the heel portion is unlikely to contact the rubber plug. Therefore, the occurrence of coring can be suppressed when the hollow needle is punctured into the rubber stopper of the vial. In addition, during dissolution preparation of a liquid such as a dissolving liquid or a chemical liquid and a drug, the liquid can be ejected vigorously from the opening of a hollow needle of the “side hole needle” type. Can be made to reach the drug, and foaming during dissolution preparation can be reduced.
Furthermore, in the conventional integrated transfer needle, since it is necessary to mold the liquid hollow needle and the drug hollow needle together, it is difficult to adjust the clamping of the upper and lower molds. There is a risk that the upper and lower molds may be damaged during molding, or burrs may occur during molding, resulting in poor communication between the liquid hollow needle and the drug hollow needle. In the present invention, the above concerns are few.
According to the second aspect of the present invention, at least one of the liquid member and the drug member communicates with the one hollow needle at a portion facing the other, and the syringe needle connection portion of the syringe is separated in a liquid-tight state. Since the female lure is connected, the transfer needle is used to prepare the drug solution in the vial, and then the prepared drug solution in the vial is further transferred to the syringe. There is no need to remove the needle from the rubber stopper of the vial and puncture the rubber stopper again with a metal hollow needle connected to a syringe. Therefore, there is no fear of occurrence of coring due to double piercing of the needle into the rubber stopper.
Moreover, at the time of the above dissolution preparation, the tip of each hollow needle does not remain in the vial, and therefore it is not necessary to separate and discard the tip of each hollow needle and each vial, The possibility of causing a needle stick accident due to the tip of each hollow needle is also low.
According to the invention described in claim 5, the filter can prevent invasion of germs into the transfer needle.
According to the eighth aspect of the present invention, when the prepared drug solution is sucked into the syringe, the filter can prevent the undissolved drug and foreign matter such as rubber pieces generated by coring from being sucked into the syringe. .
According to the ninth aspect of the present invention, since each hollow needle is contained by each skirt, the possibility of erroneous piercing by each hollow needle can be reduced.
According to the tenth aspect of the present invention, the transfer needle can be easily assembled without fail, the number of parts of the transfer needle can be reduced, the parts can be easily managed, and the transfer needle can be provided at a low cost.

  The present invention provides a transfer needle capable of dissolving and preparing a drug safely and easily and reliably in a liquid such as a solution or a chemical solution, and causing no other problems.

  Hereinafter, a first embodiment of the present invention will be described with reference to FIGS. 1 to 10. As shown in FIGS. 1 to 8, the transfer needle T includes a liquid member 1, a drug member 2, and the like. .

  The liquid member 1 includes a liquid hollow needle 6, a joint portion 7, a skirt 9, a fitting portion 10, and the like, and is integrally formed of a hard (or soft) plastic material.

  The liquid hollow needle 6 is disposed in the vertical direction, and has a base portion 6A having a cylindrical shape and a truncated cone-shaped tip portion 6B which is sharpened upward. The liquid hollow needle 6 is of a two-hole type, and a liquid passage 12 is formed in a portion extending from the conical surface to the bottom surface in one side portion (left side portion in the figure), while the liquid hollow needle 6 is formed in the vertical direction. On the other side of the needle 6 (on the right side in the figure), an air passage 13 opening in a conical surface is formed in the vertical direction. The liquid member 1 is formed with a radial communication passage 14 which communicates with the air passage 13 of the liquid hollow needle 6 at its inner end and opens to the outside at the outer end. The communication path 14 may be provided with a filter 15 that prevents invasion of germs into the transfer needle T, as indicated by phantom lines in FIGS. 2 and 3.

  The joint 7 constitutes a means for connecting the liquid member 1 and the drug member 2 in a “liquid-tight state” together with a female luer 23 of the drug member 2 to be described later. It is provided below the hollow needle 6 for liquid, is cylindrical, communicates with the liquid path 12 of the hollow needle 6 for liquid, and opens downward. The outer peripheral surface of the joint portion 7 is tapered toward the lower side.

  When the hollow needle 6 for liquid is pierced into the rubber stopper of the vial, the skirt 9 is externally fitted to the vial and guides the puncture. The skirt 9 is cylindrical and is formed on the upper part of the outer peripheral portion of the liquid member 1. Are arranged in a standing manner. The liquid hollow needle 6 is disposed at the center of the skirt 9 and is completely contained and covered by the skirt 9. Thereby, there is little fear of the false puncture by the hollow needle 6 for liquids.

  The fitting portion 10 has a cylindrical shape, and is disposed in a lower shape at the lower portion of the outer peripheral portion of the liquid member 1, and a joint portion 7 is disposed at the center thereof, and is covered by the fitting portion 10. It is covered. The upper part of the inner peripheral surface of the fitting part 10 is a screw part 16 in which a screw is formed. A circumferential groove 49 is formed on the inner peripheral surface of the lower end portion of the fitting portion 10.

  The drug member 2 is connected to the liquid member 1 in a liquid-tight state so as to be separable from the lower side, and has a base 18, a drug hollow needle 19, and a cylindrical skirt 20, and is rigid (or , Soft) plastic material.

  The upper side of the outer peripheral surface of the base 18 is formed with a screw part 22 and is screwed with the screw part 16 of the liquid member 1, and the lower side is engaged with the peripheral groove 49 through elastic deformation. A circumferential protrusion 51 is formed to be detachably engaged. In addition, by screwing the screw part 16 and the screw part 22, the circumferential groove 49 and the circumferential protrusion 51 are engaged, and by applying a force so as to release the screwing, the circumferential groove 49 and the circumferential protrusion 51 The engagement is released, and the connection between the liquid member 1 and the drug member 2 is released. A female luer 23 that opens in the vertical direction is formed at the center of the base 18, and the female luer 23 is a tapered hole formed in a tapered shape downward. When the medicinal member 2 is connected to the liquid member 1, the female luer 23 is taper-coupled so as to be separable in a liquid-tight state by inserting the joint portion 7 into the liquid luer 23. When the medicinal member 2 is separated, an injection needle connecting portion of a syringe is inserted into the member 2 and is taper-coupled so as to be separable in a liquid tight state. A filter 24 may be provided at the bottom of the female luer 23 to prevent the drug from passing through and to remove foreign substances.

  The hollow medicine needle 19 is arranged in the vertical direction and is provided below the center of the base 18. The hollow medicine needle 19 has a base portion 19A that is cylindrical and communicates with the female luer 23, and a hollow truncated cone-shaped tip portion 19B that is sharpened downward, and the base portion 19A and the tip portion 19B. The inside of both communicates. The inner diameter of the base portion 19A is smaller than the inner diameter of the female luer 23. In the illustrated example, the medicine hollow needle 19 is of a so-called “rocket needle” type in which four openings 19C are formed in the distal end portion 19B at equal intervals in the circumferential direction, but the number of openings 19C is arbitrary. is there. The hollow medicine needle 19 may be of a so-called “side hole needle” type in which an opening is formed at the tip of the base portion 19A.

  The skirt 20 is provided below the lower end portion of the outer peripheral surface of the base 18 and is fitted on the medicine hollow needle 19 to guide the skirt 20. The medicine hollow needle 19 is provided at the center of the skirt 20. Arranged and completely covered and covered by the skirt 20. With this skirt 20, there is little possibility of erroneous piercing by the hollow medicine needle 19.

  Next, with reference to FIG. 9 and FIG. 10, the dissolution preparation of a drug in a liquid such as a solution or a drug solution by the transfer needle T of the present invention and the suction of the drug solution created by this preparation into a syringe will be described. As shown in FIG. 9A, a vial 26 containing a liquid 25 such as a solution or a chemical solution, a vial 28 containing a drug 27, and a transfer needle T are prepared. Then, as shown in FIG. 9B, the vial 26 containing the liquid 25 is inserted into the skirt 9 of the liquid member 1 of the transfer needle T, and the liquid of the liquid member 1 is inserted into the rubber stopper 26A of the vial 26. The hollow needle 6 is punctured and inserted.

  Thereafter, as shown in FIG. 9C, the vial 28 containing the drug 27 is inserted into the skirt 20 of the drug member 2 of the transfer needle T, and the drug of the drug member 2 is inserted into the rubber stopper 28A of the vial 28. The hollow needle 19 is punctured and inserted. As a result, as shown in FIG. 9D, the liquid 25 in the vial 26 moves the liquid path 12 of the liquid hollow needle 6 of the transfer needle T, the joint 7, the female luer 23, and the drug hollow needle 19. Then, the medicine 27 flows into the vial 28 containing the medicine 27, and the medicine 27 is dissolved in the liquid 25, thereby preparing the prepared medicine liquid 30.

  Next, as shown in FIG. 10A, after separating the liquid member 1 and the drug member 2, the injection needle connecting portion 34 of the syringe 33 is inserted into the female luer 23 of the drug member 2. Then, after taper coupling so as to be separable in a liquid-tight state, the medicinal member 2 and the syringe 33 are turned upside down as shown in FIG.

  Thereafter, as shown in FIG. 10C, the plunger 32 of the syringe 33 is pulled to suck the prepared drug solution 30 in the vial 28 into the syringe 33, and then the vial 28 and the drug member 2 are moved into the syringe 33. Separate from. Next, as shown in FIG. 10D, if the injection needle 36 is connected to the injection needle connecting portion 34 of the syringe 33, the prepared drug solution 30 can be injected into the patient's vein or the like.

  According to the above-described embodiment, the dissolution preparation of the drug in the solution or the drug solution can be easily and reliably performed, the risk of erroneous puncture is low, and the dissolution preparation can be performed safely and hygienically. When the rubber plugs 6 and 19 are punctured into the rubber stoppers of the vials, the rubber stopper rubber is hardly cut off (coring), and there is little possibility that small pieces of rubber will be mixed into the prepared drug solution. Further, there is no generation of coring due to the needle piercing the rubber stopper twice.

  11 to 13 show a second embodiment of the present invention, which is a modification of the first embodiment, in which the liquid hollow needle 6 of the liquid member 1 is illustrated, and in the illustrated example, four openings 6C are provided at the tip portion. The so-called “rocket needle” type is formed at regular intervals in the circumferential direction. The liquid hollow needle 6 may be of a so-called “side hole needle” type in which an opening is formed at the tip of the base portion 6A. In addition, a female luer 40 that opens in the vertical direction is formed below the liquid hollow needle 6 in the liquid member 1, and communicates with the inside of the liquid hollow needle 6, and the female luer of the drug member 2. 23 is also communicated. The female luer 40 has a tapered hole formed in a tapered shape downward, and when the liquid member 1 and the drug member 2 are separated, an injection needle connecting portion of a syringe is provided therein. It is inserted so that it can be taper-coupled so as to be separable in a liquid-tight state. A ring-shaped peripheral protrusion 41 protruding downward is formed on the lower surface of the liquid member 1, and the peripheral protrusion 41 is fitted in a liquid-tight state on the upper end surface of the base 18 of the drug member 2. A ring-shaped circumferential groove 42 is formed. In this example, no air passage is formed in the liquid hollow needle 6, and no communication passage is formed in the liquid member 1. In Example 2, since the functions of the liquid member 1 and the drug member 2 are substantially the same, the liquid member 1 may be a drug member and the drug member 2 may be a liquid member. That is, at the time of dissolution preparation of a solution such as a solution or a drug solution and a drug, the hollow needle of either member may be punctured into any rubber stopper of the vial containing the liquid and the vial containing the drug, so that the dissolution preparation operation is easy. It can be done. Further, if both female lures 23 and 40 are provided with a filter, it is possible to prevent the rubber pieces and the undissolved residue of the drug due to the coring generated in the drug solution / drug vial from being sucked into the syringe.

  14 to 16 show a third embodiment of the present invention, which is a modification of the second embodiment. The fitting portion 10 of the liquid member 1 and the skirt 20 of the drug member 2 are separated by a breakable hinge 44. The liquid member 1 and the drug member 2 are integrally formed by being connected. As a result, the transfer needle T can be easily assembled without fail, the number of parts of the transfer needle T can be reduced, parts management can be easily performed, and the transfer needle T can be provided at low cost. Further, a U-shaped engagement ring 45 in a plan view projecting radially outward from the fitting portion 10 of the liquid member 1, and on the other hand, from the skirt 20 of the drug member 2, the front view is almost the same. A U-shaped engagement piece 46 protrudes radially outward. When the liquid member 1 and the drug member 2 are connected, the engagement piece 46 is inserted and engaged with the engagement ring 45 through elastic deformation. Further, a retaining portion 47 that protrudes radially outward is integrally formed on the lower outer surface of the engaging piece 46, and the retaining portion 47 engages with the engaging ring 45, so that the engaging piece 46. Is accidentally detached from the engagement ring 45, that is, the engagement between the liquid member 1 and the drug member 2 is prevented from being inadvertently released. The engagement ring 45 and the retaining portion 47 constitute a means for preventing the engagement between the liquid member 1 and the drug member 2.

  In the above configuration example, when the liquid member 1 and the drug member 2 are separated and the prepared drug solution 30 is sucked into the syringe 33, the engagement ring 45 and the engagement piece 46 are disengaged, An external force acting on the hinge 44 is applied to break the hinge 44 to separate the liquid member 1 and the drug member 2 from each other. Thereafter, the needle connection part 34 of the syringe 33 is taper-coupled to the female luer 23 of the drug member 2 in a liquid-tight state.

  17 to 23 show a fourth embodiment of the present invention. As shown in FIGS. 17 to 19, a circumferential protrusion 49 is formed on the outer peripheral surface of the fitting portion 10 of the liquid member 1. A cylindrical outer fitting portion 50 is erected from the upper end portion of the outer peripheral portion of the base of the medicinal member 2 and is fitted to the fitting portion 10, and the inner peripheral surface of the outer fitting portion 50. A circumferential groove 51 for engaging with the circumferential protrusion 49 is formed.

  Next, the method for forming the transfer needle will be described by taking the liquid member 1 of Example 4 as an example. However, the drug member 2 of Example 4 or the liquid member and drug member of other examples are also included. It can be similarly molded. The liquid member 1 of Example 4 is molded as shown in FIGS. 20 shows the initial state of the upper and lower molds 53, 54, FIG. 21 shows the time when the molds 53, 54 are clamped (drinking), FIG. 22 shows the time when injection molding is performed, Reference numeral 23 denotes a time when the medicine member 2 is taken out. Reference numeral 53A denotes an insertion hole, 54A denotes an insertion portion to be inserted into the insertion hole 53A, and the liquid hollow needle 6 is formed therebetween.

  In the present invention, since the transfer needle T includes the liquid member 1 having the liquid hollow needle 6 and the drug member 2 having the drug hollow needle 19, the insertion portion 54A for forming the liquid hollow needle 6 is used. Since the length from the tip of the insertion portion 54A to the support portion of the lower mold is short, the strength of the insertion portion 54A and the like does not become a problem. Accordingly, since the liquid hollow needle 6 can be formed by the molds 53 and 54, the small-diameter liquid hollow needle 6 can be easily formed (the same applies to the drug hollow needle 19).

  Therefore, when the hollow needles 6 and 19 of the transfer needle T are punctured into the rubber stopper of the vial, the phenomenon that the hollow needles 6 and 19 are pushed back by the elastic force of the rubber stopper, that is, the kickback phenomenon can be suppressed. Thus, the force with which each hollow needle 6, 19 is pushed back from the rubber stopper can be made small, thereby blocking the communication between each hollow needle 6, 19 and the inside of the vial, or each hollow needle 6, 19 from the rubber stopper The risk of accidental disconnection can be reduced, and coring can be suppressed.

  In addition, in the conventional integrated transfer needle, since it is necessary to mold the liquid hollow needle and the drug hollow needle together, it is difficult to adjust the clamping of the upper and lower molds. There is a risk that the upper and lower molds may be damaged during molding, or burrs may occur during molding, resulting in poor communication between the liquid hollow needle and the drug hollow needle. In the present invention, the above concerns are few.

  24 to 28 show a fifth embodiment of the present invention, in which a hollow needle 6 for liquid and a hollow needle 19 for medicine are so-called “side hole needles” having openings 6C, 19C at the distal ends of the bases 6A, 19A. For this molding, molding recesses 56 and 57 are formed in the skirts 9 and 20 of the liquid member 1 and the drug member 2.

  According to the above embodiment, since the liquid hollow needle 6 and the drug hollow needle 19 are of the so-called “side hole needle” type having the openings 6C and 19C at the distal ends of the bases 6A and 19A, the drug hollow needle When the needle 19 is punctured into the rubber stopper of the vial, the occurrence of coring can be suppressed. Further, at the time of dissolution preparation of a liquid such as a solution or a drug solution and a drug, the liquid in the vial is transferred to the drug via the liquid hollow needle 6, the joint 7, the female luer 23, and the drug hollow needle 19 of the transfer needle T. When flowing into the vial, the liquid spouts vigorously from the opening 19C of the hollow needle 19 for medicine of the “side hole needle” type, travels along the wall of the medicine vial, and reaches the medicine. Foaming during dissolution preparation can be reduced.

  29 and 30 show a comparative example 1 of the present invention, which is a modification of the first embodiment, and the liquid hollow needle 6 is of a so-called “cut needle” type. In addition, an insertion hole 59 that opens to the side is formed in a lateral direction at a substantially central portion in the vertical direction of the transfer needle T, and an insertion body 60 made of a flexible material such as an elastomer is inserted into the insertion hole 59. It is fixed. The insertion body 60 is formed with a communication passage 61 that allows the liquid hollow needle 6 and the medicine hollow needle 19 to communicate with each other. The molding method of Comparative Example 1 is similar to the molding method of the conventional transfer needle, but the slide mold for forming the insertion hole 59 that opens to the side includes the liquid hollow needle 6 and the drug hollow. Since it has a structure that supports both ends of the insertion part for forming the needle 19, it can be easily formed (the upper and lower molds may be damaged, or burrs may occur, resulting in poor communication). Less is.). The insert 60 can be easily molded, inserted, and fixed, and the transfer needle can be provided easily and inexpensively.

  31 and 32 show Comparative Example 2 of the present invention, which is a modification of Comparative Example 1, in which the liquid hollow needle 6 and the drug hollow needle 19 are of a so-called “two-hole needle” type. The holes of the hollow needles 6 and 19 communicate with each other via a pair of communication passages 61 of the insert 60. In Comparative Example 2, since the liquid hollow needle 6 and the drug hollow needle 19 are provided with a liquid path and an air path, aseptic and quick liquid exchange can be performed.

  33 and 34 show a third comparative example of the present invention, which is a modification of the second comparative example. The liquid hollow needle 6 is a so-called “two-hole needle” type, and the liquid path 12 and the air path 13 The insertion body 60 is hollow, and a cavity 63 that opens to the outside is formed inside, and a liquid communication path that allows the liquid path 12 of the liquid hollow needle 6 to communicate with the drug hollow needle 19. 64 and an air communication path 65 for communicating the air path 13 of the liquid hollow needle 6 with the cavity 63 is formed. The cavity 63 is provided with a filter 15. Comparative Example 3 has the same characteristics as Comparative Example 2.

  35 and 36 show a fourth comparative example of the present invention, which is a modification of the third comparative example, in which the insertion hole 59 has a small diameter portion 59A located between the hollow needles 6 and 19. FIG. The insert 60 is integrated with the skirt 9 via a flexible hinge 67. By deforming the hinge, most of the insert 60 except for a part of the insert 60 has a small diameter portion 59A. Has been inserted. The molding die for the small-diameter portion 59A is a slide die, and the occurrence of burrs at the abutting portion between the liquid hollow needle 6 and the drug hollow needle 19 can be reduced. This is the same in all of Comparative Examples 1 to 4 described above. Comparative Example 4 has the same characteristics as Example 3.

It is a front view which shows Example 1 of this invention. It is AA arrow sectional drawing of FIG. FIG. 3 is a longitudinal sectional view of the liquid member in FIG. 2. FIG. 4 is a plan view of FIG. 3. FIG. 4 is a bottom view of FIG. 3. FIG. 3 is a longitudinal sectional view of the drug member in FIG. 2. FIG. 7 is a plan view of FIG. 6. FIG. 7 is a bottom view of FIG. 6. It is sectional drawing explaining the melt | dissolution preparation method of the chemical | medical solution of Example 1 of this invention. It is sectional drawing explaining the melt | dissolution preparation method of the chemical | medical solution of Example 1 of this invention. It is a longitudinal cross-sectional view which shows Example 2 of this invention. FIG. 12 is a longitudinal sectional view of the liquid member in FIG. 11. FIG. 12 is a longitudinal sectional view of the drug member in FIG. 11. It is a longitudinal cross-sectional view which shows Example 3 of this invention. It is a longitudinal cross-sectional view which shows the decomposition | disassembly state of FIG. It is a longitudinal cross-sectional view which shows the use condition of FIG. It is a longitudinal cross-sectional view which shows Example 4 of this invention. FIG. 18 is a longitudinal sectional view of the liquid member in FIG. 17. FIG. 18 is a longitudinal sectional view of the drug member in FIG. 17. FIG. 19 is a longitudinal sectional view for explaining a method for forming the liquid member in FIG. 18. FIG. 19 is a longitudinal sectional view for explaining a method for forming the liquid member in FIG. 18. FIG. 19 is a longitudinal sectional view for explaining a method for forming the liquid member in FIG. 18. FIG. 19 is a longitudinal sectional view for explaining a method for forming the liquid member in FIG. 18. It is a longitudinal cross-sectional view which shows Example 5 of this invention. FIG. 25 is a longitudinal sectional view showing the liquid member in FIG. 24. FIG. 26 is a front view of FIG. 25. FIG. 25 is a longitudinal sectional view showing the drug member in FIG. 24. It is a front view of FIG. It is a longitudinal cross-sectional view which shows the comparative example 1 of this invention. FIG. 30 is a longitudinal sectional view showing the exploded state of FIG. 29. It is a longitudinal cross-sectional view which shows the comparative example 2 of this invention. FIG. 32 is a longitudinal sectional view showing an exploded state of FIG. 31. It is a longitudinal cross-sectional view which shows the comparative example 3 of this invention. It is a longitudinal cross-sectional view which shows the decomposition | disassembly state of FIG. It is a longitudinal cross-sectional view which shows the comparative example 4 of this invention. FIG. 36 is a longitudinal sectional view showing an exploded state of FIG. 35. It is a longitudinal cross-sectional view explaining the puncture to the rubber stopper of a transfer needle. It is a longitudinal cross-sectional view which shows the conventional transfer needle. FIG. 39 is a longitudinal sectional view for explaining a method for forming the transfer needle of FIG. 38. FIG. 39 is a longitudinal sectional view for explaining a method for forming the transfer needle of FIG. 38. It is a longitudinal cross-sectional view explaining the puncture to the rubber stopper of the vial of a transfer needle.

Explanation of symbols

T transfer needle 1 liquid member 2 drug member 6 liquid hollow needle 7 joint 9 skirt 12 liquid path 13 air path 14 communication path 15 filter 16 female screw part 19 drug hollow needle 20 skirt 22 male screw part 23, 40 Female luer 24 Filter 44 Hinge 45 Engagement ring 46 Engagement piece 49 Circumferential protrusion 51 Circumferential groove

Claims (15)

A. A liquid member;
B. It has a medicinal member that is separably connected or connected to the liquid member in a liquid-tight state,
The liquid member
-Having a hollow needle for liquid projecting on the opposite side to the drug member side,
The medicinal member is
A transfer needle having a drug hollow needle that protrudes opposite to the liquid member and communicates with the liquid hollow needle. In at least one of the liquid member and the drug member,
The transfer needle according to claim 1, further comprising a female luer that communicates with the one hollow needle and is connected to the syringe needle connection portion so as to be separable in a liquid-tight state.   The transfer needle according to claim 1 or 2, wherein the liquid member and the drug member are connected by an engaging means. Hollow needle for liquid
A. A liquid channel communicating with the hollow needle for medicine,
B. Has an air passage,
Liquid member
-The transfer needle in any one of Claims 1-3 which have a communicating path which connects an air path with the exterior.   The transfer needle according to claim 4, wherein a filter is provided in the communication path. A hollow needle for liquid and / or a hollow needle for medicine
A. A base having a cylindrical shape;
B. Having a sharpened tip,
The transfer needle according to claim 1, wherein an opening is formed at the base. A hollow needle for liquid and / or a hollow needle for medicine
A. A base having a cylindrical shape;
B. Having a sharpened tip,
The transfer needle according to any one of claims 1 to 5, wherein an opening is formed at the tip.   The transfer needle according to claim 1, wherein a female luer is provided with a filter. In the liquid member,
A skirt that protrudes on the opposite side of the medicinal member and has a hollow needle for liquid is provided,
For medicinal parts,
The transfer needle according to any one of claims 1 to 8, further comprising a skirt that protrudes on the opposite side of the liquid member and includes a hollow needle for medicine.   The transfer needle according to claim 1, wherein the liquid member and the drug member are connected by a flexible and breakable hinge.   The transfer needle according to claim 1, wherein the liquid member and the drug member are detachably engaged with each other, and means for preventing release of the engagement is provided. A. A liquid member;
B. A drug member integrated with the liquid member;
The liquid member
-Having a hollow needle for liquid projecting on the opposite side to the drug member side,
The medicinal member is
A hollow needle for a medicine projecting on the opposite side of the liquid member and communicating with the hollow needle for liquid;
Between the hollow needle for liquid and the hollow needle for medicine, an insertion hole that opens to the side is formed,
A transfer needle in which an insertion body for communicating both hollow needles is inserted into an insertion hole.   The transfer needle according to claim 12, wherein the hollow needle for liquid and / or the hollow needle for medicine has two openings at the tip. An air passage communicating with the liquid hollow needle is formed,
The transfer needle according to claim 12 or 13, wherein a filter is provided in the air passage.   The transfer needle according to any one of claims 12 to 14, wherein the insert is integrated via a hinge.

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