JP2006290792A - Anti-inflammatory agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an odorless anti-inflammatory agent for preventing or alleviating pain such as joint pain accompanied by inflammation and relaxing discomfort followed by the pain by safely and surely and readily permeating or absorbing an active ingredient from the skin into the affected area. <P>SOLUTION: Mixed powder obtained by formulating methylsulfonylmethane (MSM) derived from nature and used as a health food with Aphanizomenon flos-aquae (AFA) so as to create synergistic effect is mixed with a natural jojoba oil to provide ointment-like or low-viscosity mixture and the mixture is percutaneously permeated or absorbed into cells in a human body to enable prophylaxis or alleviation of pain such as joint pain accompanied by inflammation and relaxation of discomfort. A simple method for applying the agent to the skin comprises applying the agent to the skin by utilizing white vaseline, olive oil, etc., or applying the agent after spraying a propellant such as LP gas or attaching the agent by utilizing a taping tape, etc., excellent in adhesiveness, stretchability and air permeability. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention permeates and absorbs active ingredients from the skin of the living body into the cells of the living body for the purpose of preventing, reducing, or alleviating the discomfort associated with inflammation such as a wide range of joint pain, neuralgia, and back pain. It relates to anti-inflammatory agents.

In recent years, products called so-called health foods have attracted attention, and various types of products have been sold. Many of these are known as supplements for the dietary life of unbalanced people, or for taking active ingredients orally for the prevention and response of lifestyle-related diseases. (Patent Document 1)
In addition, those that are applied directly to the skin of a living body and have an anti-inflammatory action for the prevention / reduction of inflammation such as joint pain, neuralgia, and back pain are also known. (Patent Document 2)

  Causes of pain due to inflammation as described above are various causes such as changes in dietary habits, lack of exercise, weight gain, body flexibility / muscular strength, bone density decline, osteoporosis, tissue damage, exercise damage, etc. Various factors are considered. And the above factors are combined and cause pain due to inflammation. In addition, the bias of nutritional components in the dietary life is due to the fact that the body's inherent defense function and metabolic ability are reduced. Therefore, a rapid biological transdermal anti-inflammatory agent that works directly on the cause of pain caused by inflammation is desired.

  According to the present inventor, methylsulfonylmethane (hereinafter referred to as MSM) is an organic sulfur compound that exists in nature and is essential for living organisms. It must also be contained in fresh milk, green-yellow vegetables, tea leaves, etc., and in human urine. In addition, MSM molecules are small and water-soluble, making the internal and external pressures of the cell membrane uniform and increasing its permeability, making active use of the properties that facilitate the rapid excretion of intracellular harmful substances and facilitate the uptake of nutrients It's a good thing.

  The general mechanism of pain will be described based on the structural diagram of the cell membrane in FIG. 1 and the explanatory diagram of the metabolic pathway of arachidonic acid involved in inflammation in FIG. The cell membrane 1 shown in the structural diagram of the cell membrane in FIG. 1 plays a role in creating an independent environment inside the cell and maintains a homeostasis (homeostasis) inside and outside the cell while exchanging materials and exchanging information with the outside world. have. The main components of the cell membrane 1 are a double polar and nonpolar phospholipid 2 and a component protein 3 embedded in the cell membrane. Furthermore, it is the peripheral protein 4 that is in charge of exchange with the outside world, and the role of the antenna is the sugar chain 5. In general, when a physical or chemical stimulus is applied to the cell membrane 1, the enzyme phospholipase A2 is activated as shown in the metabolic pathway of arachidonic acid in FIG. 2, and arachidonic acid of the cell membrane phospholipid is converted from nonpolar phospholipid 2. 6 is released. Endoperoxide prostaglandins G2 and H2 (code 8) are generated from the arachidonic acid 7 released into the cytoplasm by activation of the enzyme cyclooxygenase (COX), and inflammation is induced by prostaglandins I2, E2, and F2 (code 9). , Fever and pain 10 occur. In addition, thromboxane A2 (symbol 11) causes thrombus formation and asthma attack 12. In other metabolic pathways, activation of the enzyme 5-lipoxygenase (LOX) produces 5-HPTEE (5-hydroperoxyicosatetraene) 13, which is caused by leukotrienes A4, B4, C4, D4, E4 (symbol 14). Causes inflammation and asthma attack 15.

  Conventional anti-inflammatory agents for external use relieve pain caused by inflammation by inhibiting the activation of the enzyme by chemically reacting the aforementioned free arachidonic acid. On the other hand, since MSM makes the internal and external pressures of the cell membrane uniform and enhances its permeability, the present inventor has paid attention to the effect of rapidly excluding intracellular free free arachidonic acid physically outside the membrane. The present inventor has found that by adding and mixing aphanizomenon floss aqua (hereinafter referred to as AFA) to this, the enhancement of supplementation of necessary components into the cell membrane is made more effective.

  Conventional health foods are mainly taken orally, and after digestion and absorption, all the components are not necessarily delivered efficiently and efficiently to necessary parts of the living body. Furthermore, depending on the individual difference of the living body, the possibility that the functional balance of each organ of the living body may be lost during the digestion and absorption process due to the intake of the component cannot be denied.

  For this reason, in most cases, the above-mentioned inflammation occurs in a part of the living body that is relatively close to the skin, so that the pain caused by inflammation can be directly penetrated into the affected area using MSM powder through the skin and has a relaxing effect (immediate effect). In addition, AFA powder is mixed to adjust the preventive effect (slow-acting effect) of inflammation, and these are mixed with natural jojoba oil at a certain ratio and applied to the living epidermis. It was necessary to have a relaxation effect, immediate effect, and curability.

JP 2004-113141 A JP 2004-149441 A

  Since the present inventor is considered to be the oldest organism in the earth that has inhabited AFA since 3.5 billion years ago and is the prototype of somatic cells, AFA, which can be said to be somatic cells themselves, is directly transmitted through the skin. It is intended to promote the rapid repair of damaged somatic cells by supplementing them. And for pain caused by inflammation, MSM powder and AFA powder for the purpose of maintaining health including strengthening anti-inflammatory action and nutritional supplements are mixed with natural jojoba oil and applied, spread and applied transdermally. The object is to provide an anti-inflammatory agent that has been made possible and has a high immediate effect.

  In addition, the object of the present invention is to allow the user to easily permeate and absorb the above-mentioned health food through the skin to the affected area, and to directly cause pain etc. by a physical mechanism different from conventional oral and external anti-inflammatory agents. The excess free arachidonic acid is excreted out of the cell and the function of the cell is restored. In addition, this method can provide an effective odorless anti-inflammatory agent.

  In order to achieve the above-mentioned object, the present invention appropriately mixes naturally-derived ingredients used as health foods in order to obtain a synergistic effect, and promptly removes them from the skin using an optimal method. It is intended to provide an odorless anti-inflammatory agent that can be absorbed and penetrated into sites having symptoms such as pain due to inflammation.

  The present invention according to claim 1 is a mixture of natural MSM powder and AFA powder mixed at a certain ratio in natural jojoba oil at a certain ratio to form an ointment-like or low-viscosity mixture. The object is to obtain an anti-inflammatory agent which can be applied to the skin of a living body.

  The present invention according to claim 2 provides the anti-inflammatory agent according to claim 1, wherein the mixing ratio of the MSM powder and the AFA powder is 1 to 0.25 to 4 in weight ratio.

  The present invention described in claim 3 is a white powder of at least 30-90 mesh, the MSM powder is naturally derived, has an MSM purity of 99.0% or more, a melting point of 107 ° C or more, an ash content of 0.2% or less, The anti-inflammatory agent according to claim 1 or 2, which is 0.3% or less.

  The present invention according to claim 4 is a 30-90 mesh green powder in which at least AFA powder is a natural material, nutrients are 60-70 g protein, carbohydrates 15-25 g, lipids 1-8 g, vitamins and minerals per 100 g 2 to 8 g, chlorophyll a is 0.5 to 1.2 g, and the water content is 1 to 5 g. 3. The anti-inflammatory agent according to claim 1 or 2 is obtained.

  In the present invention according to claim 5, in order to promote penetration and absorption of the living body through the skin, 0.2 parts of a mixed powder obtained by blending MSM powder and AFA powder at a certain ratio with 1 part by weight of natural jojoba oil. The anti-inflammatory agent according to any one of claims 1 to 4 is obtained by mixing and dispersing in an amount of ˜2 parts by weight into an ointment-like or low-viscosity mixture.

  In the present invention according to claim 6, white petrolatum or olive oil is mixed in a mixture of natural jojoba oil, MSM powder and AFA powder at a certain ratio in order to make it easy to apply to the skin of a living body. It exists in obtaining the anti-inflammatory agent of Claim 1 thru | or 5 characterized by the above-mentioned.

  In the present invention according to claim 7, a low-viscosity mixture in which MSM powder and AFA powder are mixed and dispersed in natural jojoba oil is used as a propellant such as LP gas in order to facilitate spraying the living body through the skin. The anti-inflammatory agent according to any one of claims 1 to 5 is obtained, wherein the anti-inflammatory agent can be sprayed by mixing at a constant ratio.

  In the present invention described in claim 8, natural jojoba oil, MSM powder, and AFA powder are mixed at a certain ratio on an adhesive surface of an adhesive tape that has adhesiveness, stretchability, and air permeability, and is placed in an ointment form. The anti-inflammatory agent according to any one of claims 1 to 5, which can be attached to the skin of a living body.

  The present invention will be described in detail below for each of the claims. In the present invention according to any one of claims 1 to 8, natural jojoba oil is mixed with a mixture of MSM powder and AFA powder as essential active ingredients at an appropriate ratio so as to produce a synergistic effect as described later. It is necessary to mix in proportions to make an ointment-like or low viscosity mixture.

  MSM is an organic sulfur compound indispensable for living organisms, and is a natural nutritional component present in almost all living organisms. MSM is a substance contained in many foods, but since the intake of processed foods is increasing, most organic sulfur is destroyed by washing, processing, cooking, etc., so the sulfur required for the living body is deficient It is an element necessary for supplementing the organic sulfur compound essential for the living body.

  MSM is also very effective in alleviating and improving pain caused by inflammation such as arthritis and rheumatism. The fact that the sulfur component has an anti-inflammatory effect is also apparent from the coping method that all pains are alleviated by soaking in a hot spring containing a large amount of sulfur, and the present inventor has made this one of the constitutions of the invention. did.

  The reason why MSM has an effect of suppressing inflammation such as joint pain is because the molecule of MSM is very small and water-soluble, and therefore has the property of being easily absorbed into cells. In addition, MSM absorbed into cells makes it possible to equalize the internal and external pressures of the cell membrane and prevent pressure from accumulating in cells, tissues, and joints. Furthermore, it has a function of increasing the permeability of the cell membrane, and as a result, excess can be discharged from the cell and the inflow of nutrients into the cell can be promoted. Thereby, the pain accompanying inflammation is relieved and the countermeasure for prevention becomes possible.

The MSM standard applied to the present invention will be described below.

  Secondly, AFA is a natural food that contains not only proteins, carbohydrates and lipids, but also vitamins, minerals, pigments, and active enzymes in a rich manner, and contains almost all the essential nutrients of living cells in a balanced manner. These nutrients have a composition similar to that of somatic cells, and are almost 100% digested and absorbed by the living body.

  One of the indirect causes of inflammation such as joint pain is the presence of excess reactive oxygen that causes cell acidification. The function to control these is originally in the cells, and this function declines due to aging or dietary distortion, but daily intake of antioxidants or enzyme SOD compensates for the deterioration of the function. The utility of AFA is effective for repairing and regenerating such once damaged cells, and promotes cell metabolism, and the present inventor made use of the utility of such AFA as a constituent element.

  The balance of essential amino acids and essential fatty acids in AFA is close to the ideal value required for cells, vitamins and minerals are all necessary for cells, and enzymes involved in antioxidant and anti-inflammatory effects It also contains dyes, nucleic acids and the like. Therefore, it has been discovered and actively used that it is a substance that can ingest all of the components that strengthen the function and reinforce the metabolism of cells.

Next, the AFA standard is described.
AFA is a pure natural blue algae (Blue Green Algae) native to Klamath Lake in Oregon, USA.

Next, the manufacturing method of AFA is described.
First Step: Collection Use a rotary belt conveyor that collects AFA floating 1-2 m below the surface of the water at Klamath Lake, Oregon, from July to October.
Second step: microfiltration with a filter Using a special filter combination of about 0.1 micron, a special filter is used to remove particulate foreign matter from the collected AFA.
Third step: Centrifugation Next, impurities such as sand and silt are removed from the AFA at room temperature using a centrifugal separator. The size of the filtered AFA is about 8-12 microns.
Fourth Step: Freeze Storage The filtered AFA is flash-frozen at −40 ° C. and then stored in the freezer until the freeze-drying process.
Fifth step: Freeze-drying method drying Freeze matter is sublimated and dried with a freeze-drying device in a vacuum state of 1/1000 of 1 atm.
Further, as another drying method, it may be spray-dried, that is, after passing through a centrifugal filtration device, sprayed from the drying tower of the spray-drying device, and instantaneously dried with hot air of 150 to 200 ° C.
Sixth step: sieve (sieving) fraction Sieve powder into 30-90 mesh.

Next, the standard of natural jojoba oil will be described. Natural jojoba oil is extracted from the fruit of the strong vital plant jojoba that grows naturally in the desert, and uses the fact that it is very similar to living body sebum and has excellent osmotic power. It is. It is oil-soluble and insoluble in water and ethanol, has a specific gravity of 0.853 to 0.875 at 20 ° C, and a freezing point of 7.0 to 10.5 ° C.
Further, depending on the method of application to the living body epidermis, white petrolatum or olive oil is added as described later to provide an anti-inflammatory agent that can be easily used by the user.

First, the mechanism by which a synergistic effect is produced by mixing MSM and AFA will be described with reference to the drawings. FIG. 1 shows the structure of a general cell membrane, FIG. 3 shows the cell structure of cyanobacteria (AFA), and FIG. 4 shows the conversion process of sulfur containing MSM. Cyanobacteria play an important role in the sulfur cycle in nature. That is, the cyanobacteria absorb inorganic sulfur 18 from the outside into cells containing DNA 17 through the cell wall 16 of FIG. 3 to convert it into organic sulfur, and release volatile dimethyl sulfide (DMS) 19 to the outside. This DMS is an ozone layer in the atmosphere as shown in FIG. 4, and passes through dimethyl sulfoxide (DMSO) 20 and then dimethyl sulfone (DMSO ₂ , which is another name for MSM, and its chemical formula is shown in 21) 21 Is converted to These are dissolved in water vapor in the atmosphere, dissolved in rain, returned to the ground, and absorbed and concentrated by plants.
Thus, AFA, which is a kind of cyanobacteria, has a close relationship with MSM in the sulfur circulation cycle, and MSM, which is an organic sulfur compound, is actively taken into AFA cells from this relationship. In addition, many of the proteins contained in AFA are called glycoproteins (glycoproteins), which are peripheral proteins that exchange information with the outside in the cell membrane shown in the structural diagram of the cell membrane in FIG. Strong affinity with 4 sugar chains 5. Due to this strong affinity, AFA that incorporates MSM is recognized and induced as a preferred substance for the cell membrane and is joined to the cell membrane, and then the permeability of the cell membrane is enhanced by the properties of MSM. Therefore, by mixing MSM and AFA rather than using each of them alone, it is possible to reach the cell membrane of the living body quickly, efficiently drain excess to the outside of the cell membrane, and supply active ingredients that promote metabolism into the cell membrane. We discovered that we can do it and used it positively.

  The production method of the present invention comprises mixing a predetermined amount of the MSM powder and AFA powder with natural jojoba oil in a specified mixing ratio, and mixing and dispersing at room temperature with a rotor / stator stirrer or the like to form an ointment or It is a mixture with low viscosity.

  In the present invention, the above-described two-component MSM powder and AFA powder are first mixed so as to exhibit a synergistic effect. In other words, AFA that incorporates MSM is quickly recognized and induced in the cell membrane, quickly reaches and joins the cell membrane, and then increases the permeability of the cell membrane due to the effect of MSM. Penetrate into the cell membrane. Furthermore, these components are mixed and dispersed in natural jojoba oil in order to efficiently and effectively absorb and permeate these components into the skin.

  As described above, since components that promote joint metabolism and other inflammation and promote metabolism are also included, it is possible to reinforce the anti-inflammatory action and prevent the onset of arthritis and the like.

  When the above-mentioned essential components, MSM powder and AFA powder are mixed, the application range of the mixing ratio in which the present invention can be carried out is as follows: MSM powder 1 to AFA powder 0.25 (FIG. The symbol C) to 4 (Fig. 5 symbol F), and the preferred recommended range of the present invention is 1 MSM powder to AFA powder 0.5 (Fig. 5 symbol D) to 1 (Fig. 5 sign E). However, it is not always necessary to be within this recommended range, and in this case, it is calculated with an emphasis on immediate effect in consideration of the balance between the mitigation and prevention effects against inflammation.

FIG. 5 shows the evaluation of the effect of alleviating and preventing inflammation by the weight ratio of MSM powder and AFA powder. As the weight ratio of MSM powder increases from 1 on the left to 5-7 on the right, the inflammation mitigating effect, that is, the immediate effect increases, but 7-10 (MSM powder alone) decreases the immediate effect. . By adding AFA powder in this way, there is a mixing ratio (MSM powder is in a range of 2 or more by weight) that is greater than the effect of the MSM powder alone. On the other hand, as the weight ratio of AFA powder increases from 1 on the right to 5 on the left, the preventive effect of inflammation, that is, the delayed effect increases, but 5-10 (AFA powder alone) decreases the delayed effect. . Thus, there exists a mixing ratio (AFA powder is 2 or more by weight ratio) which becomes larger than the effect of a single AFA powder by adding MSM powder.
In FIG. 5, the symbol A indicates that the MSM powder has a weight ratio of 2 to 8 and the AFA powder has a weight ratio of 8 to 2. That is, MSM powder 1 to AFA powder 0.25 (sign C) to 4 (sign F) is an application range of the mixing ratio according to the present invention, which is more effective than each simple substance. Moreover, the code | symbol B is the range whose MSM powder is 5 to 6.7 by weight ratio, and AFA is the range which is 5 to 3.3 by weight ratio. That is, MSM powder 1 to AFA powder 0.5 (symbol D) to 1 (symbol E) is a recommended range of a preferable mixing ratio in the present invention. These mixing ratios are recommended when the immediate effect is mainly considered.

  Next, the natural jojoba oil used in claims 1 to 8 of the present invention is a liquid wax comprising an ester of a linear higher unsaturated fatty acid and a higher unsaturated alcohol, and is similar to living body sebum. We actively used the effects of promoting the metabolism of the skin itself, such as non-stickiness, osmotic power, increased sebum secretion, and prevention of drying and lipid peroxidation. This natural jojoba oil has been used as a skin care and hair care product.

  FIG. 6 shows the alleviation / prevention effect on inflammation and the absorption / penetration of the mixture into the skin when a mixture of MSM powder and AFA powder is mixed with natural jojoba oil. In FIG. 6, the symbol G indicates that the weight ratio of natural jojoba oil is 8.3 to 3.3, and the mixture of MSM powder and AFA powder is 1.7 to 6.7 by weight ratio. That is, it is in the range of natural jojoba oil 1-pair mixture 0.2 (sign I) to 2 (sign L). When the weight ratio of natural jojoba oil exceeds 8.3, absorption / penetration into the skin becomes saturated, and when the mixture exceeds 6.7 by weight ratio, the inflammation prevention / relief effect becomes saturated. Therefore, the range of this code G is the application range of the mixing ratio of the present invention. Moreover, the code | symbol H is the weight ratio of natural jojoba oil 8-8, and the mixture of MSM powder and AFA powder is 2-5 by weight ratio. That is, a natural jojoba oil pair mixture 0.25 (sign J) to 1 (sign K), which is a recommended range of the preferred mixing ratio of the present invention. This is a range obtained from the results of emphasizing absorption and penetration into the skin while maintaining the necessary mitigation and prevention effects on inflammation. However, it is not necessarily limited to this ratio depending on the situation.

  Next, the invention according to claim 6 mixes white petrolatum as an ointment base, which is used in many cosmetics such as creams. Alternatively, olive oil mainly composed of oleic acid and palmitic acid is used so as to have a viscosity almost equal to that of a normal ointment type (ointment-like), but these are safe and stable substances. In addition, it is possible to meet the needs of users who aim for ease of application to the skin and to obtain an odorless anti-inflammatory agent.

  Next, in the invention according to claim 7, a propellant such as LP gas ordinarily used is sealed in an aerosol can in order to quickly absorb and permeate a site having symptoms such as pain caused by inflammation through the skin. The spraying / dispersing method was used. In this production method, LP gas is used by dispersing a mixture having a lower viscosity than ordinary ointment type (ointment-like). This aerosol type is widely applied in various fields, and this method is adopted. By doing so, the active ingredient can be easily and reliably applied to the skin of a living body.

  Next, the invention according to claim 8 is a method for rapidly absorbing and penetrating a site having symptoms such as pain due to inflammation through the skin. Apply and use what was adjusted to have a viscosity almost equal to the type (ointment). The taping tape is widely used particularly for the purpose of supporting muscles that move the joints, and the tape to which the active ingredient is attached makes it possible to adjust and select the contact time with the skin.

  According to the inventions described in claims 1 to 5, each substance composed of MSM and AFA, which are effective in preventing and / or alleviating inflammation such as joint pain, neuralgia, and back pain, are mixed so as to obtain a synergistic effect. Natural jojoba oil is mixed with the product to make an ointment-like or low-viscosity mixture, which can be directly penetrated and absorbed from the skin of the living body into parts with symptoms such as pain due to inflammation, so that the pain can be recovered quickly and immediately. There is. It is also convenient to use because it is an odorless anti-inflammatory agent. Furthermore, the anti-inflammatory agent according to the present invention is a naturally-derived component and has no side effects on the living body and can be used with peace of mind by users.

  According to the sixth aspect of the present invention, it is possible to permeate and absorb a site having symptoms such as pain due to inflammation by applying to the skin, so that the recovery of the pain is quick and immediate effect can be expected. It is also convenient for use because of its odorless anti-inflammatory agent.

  According to the seventh aspect of the present invention, it was possible to penetrate and absorb a site having symptoms such as pain due to inflammation by spraying the skin through the skin, so that the pain can be quickly recovered and immediate effect can be expected. It is also convenient for use because of its odorless anti-inflammatory agent.

  According to the eighth aspect of the present invention, a mixture of MSM powder and AFA powder is mixed with natural jojoba oil at a certain ratio on the adhesive surface of a taping tape having adhesiveness, stretchability, and breathability to form an ointment. It is convenient to use as an anti-inflammatory agent because of the arrangement of things.

  As described above, according to the present invention, natural MSM powder and AFA powder, which have an effect of preventing and / or alleviating inflammation such as joint pain, neuralgia, and back pain, are mixed to obtain a synergistic effect. Natural jojoba oil is mixed into an ointment-like or low-viscosity mixture, and these are permeated and absorbed directly from the skin into sites with symptoms such as pain caused by inflammation. A promising anti-inflammatory agent was obtained. It is also convenient for use because of its odorless anti-inflammatory agent. Furthermore, the anti-inflammatory agent according to the present invention is a naturally-derived component and has no side effects on the living body and can be used with peace of mind by users.

  Next, examples of the anti-inflammatory agent according to the present invention will be described together with a table.

  What changed the compounding example of each component about the anti-inflammatory agent which concerns on this invention, and its effect are shown to (1)-(30) of Table 3.

  In Table 3, anti-inflammatory agents having different blends of MSM and AFA powder were applied to the affected area every day before going to bed, and the state of pain was observed over time. The test subjects were 3 men and women in their 40s, 50s and 60s with pains such as joint pain, low back pain, and stiff shoulders, for a total of 18 people. In addition, the appearance of immediate effect in anti-inflammatory action indicates the number of days that the subject felt that the pain was relieved, and the appearance of delayed action indicates the number of months of healing when the recurrence of pain became less felt. ing.

In Table 3, (1) to (6) are MSM simple substance and 80 mesh powder, and (25) to (30) are AFA simple substance and 60 mesh powder.
(7) to (12) are MSM 800 mg, 30 mesh powder, purity 99.8%, melting point 107 ° C., ash content 0.1%, moisture content 0.1%. AFA was 200 mg, 90 mesh powder, nutrients were 70 g protein per 100 g, carbohydrates 25 g, lipids 1 g, vitamins and minerals 2 g, chlorophyll a 1.2 g, and water 1 g.
(13) to (18) are MSM of 500 mg, 80 mesh powder, purity of 99.8%, melting point of 107 ° C., ash content of 0.2%, and water content of 0.3%. AFA was 500 mg, 60 mesh powder, and nutrients were 70 g protein per 100 g, 15 g carbohydrate, 5 g lipid, 5 g vitamin / mineral, 1 g chlorophyll a, and 4 g water.
(19) to (24) are MSM of 200 mg, 90 mesh powder, purity of 99.0%, melting point of 107 ° C., ash content of 0.1%, and water content of 0.3%. AFA was 800 mg, 30 mesh powder, nutrients were 60 g protein per 100 g, carbohydrates 20 g, lipids 8 g, vitamins and minerals 8 g, chlorophyll a 0.5 g, and moisture 3.5 g.
Thus, the MSM powder is at least a 30-90 mesh powder of natural origin, if the purity is 99.0% or more, the melting point is 107 ° C. or more, the ash content is 0.2% or less, and the water content is 0.3% or less. Good. AFA powder is at least a 30-90 mesh green powder of natural materials. Nutrients are 60-70 g of protein, 15-25 g of carbohydrates, 1-8 g of lipids, 2-8 g of vitamins and minerals, chlorophyll a per 100 g. Of 0.5 to 1.2 g and moisture of 1 to 5 g.

From Table 3, (1) to (6) using MSM powder alone have a slow effect with an immediate effect of 4 to 5 days and a delayed effect of 8 to 9 months. Moreover, in the case of (25)-(30) which used the powder of AFA independently, an immediate effect is late | slow with 5-8 days and a delayed effect is 7-8 months. Compared with these, the examples (7) to (24) of the present invention have an immediate effect of 0.5 to 2 days due to the synergistic effect of MSM and AFA, and a delayed effect of 3 to 6 months. It has an excellent anti-inflammatory effect with a fast healing month. (Corresponding to claims 1 to 5)
In Table 3, natural jojoba oil, which reinforces absorption and penetration into the skin, has a one-to-one ratio to the mixture of MSM powder and AFA powder in order to effectively exhibit immediate and delayed effects on inflammation. Mixed in proportion.

Next, Table 4 shows a mixture of MSM powder and AFA powder mixed with natural jojoba oil, and those mixed with white petrolatum or olive oil for direct application, spray application, and taping tape. The evaluation of sex was shown. In addition to these evaluations, in the remarks column, the penetration and absorption of each mixture into the skin and the viscosity compared to those of a commonly used ointment type (ointment type) are shown. In the viscosity comparison column, “slightly low” and “pretty low” mean “low viscosity” in the present invention.

In order to produce a mixture for direct application, a mixture of MSM powder and AFA powder is mixed and dispersed in natural jojoba oil so that it has a viscosity equivalent to or slightly lower than that of a normal ointment type (ointment-like), Add white petrolatum or olive oil to adjust viscosity as needed.
In addition, to produce a mixture for spray application, a mixture of MSM powder and AFA powder is mixed with natural jojoba oil so that it can be dispersed in LP gas with a much lower viscosity than the usual ointment type (ointment form) Disperse.
In order to produce a mixture for taping tape, a mixture of MSM powder and AFA powder is mixed and dispersed in natural jojoba oil so that it has a viscosity equivalent to or slightly lower than the usual ointment type (ointment form). Further, white petrolatum or olive oil is added to adjust the viscosity as necessary.

  In Table 4, “appropriate” when applied directly to the skin has a viscosity that remains firmly on the epidermis when applied to the skin, and “appropriately applied” means that it is slightly out of the viscosity range but can be used. is there. In addition, “optimum” in spray coating has the optimum viscosity that can be mixed and dispersed in propellants such as LP gas, and “suitable” means that the viscosity is appropriate. "Is slightly out of the viscosity range but can be used, and" unsuitable "indicates that it is significantly out of the range. In addition, “appropriate” in sticking tape has a viscosity that stays firmly on the adhesive surface when placed on the adhesive surface of the tape, and “appropriately” means that it is slightly out of the viscosity range but can be used. It is. In addition, “appropriate” in penetrating / absorbing means that it penetrates the skin smoothly with a slight rubbing when applied to the skin, and “appropriately conforming” means that the degree of friction is slightly large. It can be used, and “unsuitable” indicates that it does not easily penetrate even after a long period of friction.

In Table 4, in (1) to (30), the MSM powder is 800 to 200 mg, and the AFA powder is also 200 to 800 mg. Moreover, natural jojoba oil is 500-5000 mg. When 500 mg of natural jojoba oil is mixed, it has a high viscosity and is not suitable for spray coating. (1) to (3) are mixed with 500 mg of petroleum jelly, and (4) to (6) are mixed with 250 mg of petroleum jelly. (10) to (12) are mixed with 1000 mg of olive oil, and (13) to (15) are mixed with 500 mg of olive oil. Vaseline is highly viscous and unsuitable for spray application, but olive oil is less viscous than petrolatum and can be used for spray application.
In (1) to (6), MSM is a naturally derived 90 mesh powder having a purity of 99.0%, a melting point of 107 ° C., an ash content of 0.1%, and a water content of 0.3%. AFA is 30 mesh powder, nutrients are 60g protein per 100g, carbohydrates 20g, lipids 8g, vitamins and minerals 8g, chlorophyll a 0.5g, and water 3.5g.
In (7) to (21), MSM is a naturally derived 80 mesh powder having a purity of 99.8%, a melting point of 107 ° C., an ash content of 0.2%, and a water content of 0.3%. AFA is a 60 mesh powder. Nutrients are 70g protein per 100g, carbohydrates 15g, lipids 5g, vitamins and minerals 5g, chlorophyll a 1g, and moisture 4g.
In (22) to (30), MSM is a naturally derived 30 mesh powder having a purity of 99.8%, a melting point of 107 ° C., an ash content of 0.1%, and a water content of 0.1%. AFA is a 90-mesh powder, and the nutrient is 70 g of protein, 100 g of carbohydrate, 25 g of carbohydrate, 1 g of lipid, 2 g of vitamin / mineral, 1.2 g of chlorophyll a, and 1 g of water.
Thus, the MSM powder is a white powder of at least 30 to 90 mesh derived from nature, having a purity of 99.0% or more, a melting point of 107 ° C or more, an ash content of 0.2% or less, and a water content of 0.3% or less. I just need it. The AFA powder is at least a 30-90 mesh green powder of natural materials. Nutrients are 60-70 g of protein, 15-25 g of carbohydrates, 1-8 g of lipids, 2-8 g of vitamins and minerals, chlorophyll a per 100 g. Is 0.5 to 1.2 g and the water content may be 1 to 5 g.

  Also, in the case of spray coating, jojoba oil is mixed and dispersed at a ratio of 3 to 5 times the mixture of MSM powder and AFA powder (22) to (30) is dispersed in propellant such as LP gas. It has moderate viscosity. In the case of direct application and tape sticking use, about 1/4 of petroleum jelly added to jojoba oil (4) to (6) and about 1/2 of olive oil added to jojoba oil Alternatively, (13) to (21) in which only jojoba oil is mixed in a mixture of MSM powder and AFA powder 1 to 1.5 times has an appropriate viscosity. These formulation examples serve as a guide for the amount used per day. (Corresponding to claims 6-8)

MSM is manufactured by American Ingredient. This product is a product from Teda pine, and when taken orally as a health food, the recommended daily intake is 1 to 1.5 g. When it is mixed with AFA and used in a transdermal manner as in the invention, 1 g or less is sufficient.
Table 5 shows the component composition of MSM powder and its characteristics.

In Table 5, “optimum” in penetrability means that it penetrates smoothly into the skin when applied to the skin, and “suitable” means that the friction penetrates to some extent. "Appropriately conforming" means that the degree of friction is slightly large, but it can be used, and "unsuitable" indicates that it does not easily penetrate even after a long period of friction. In addition, “optimal” in mixing indicates that a slight amount of stirring is sufficient when mixing with AFA powder and natural jojoba oil, and “suitable” indicates that general mechanical stirring is sufficient. “Appropriately” means that even mechanical agitation takes time but can be used.
MSM powder tends to solidify as the number of meshes increases, but it can be used by adding 0.5% of silicon dioxide.

  As shown in Table 5, the composition of (5) and (6) is about 99.8% for MSM powder, about 80 mesh, moisture is 0.3% or less, and 0.5% of silicon dioxide is added to the skin. It is excellent in permeability and mixing with other components, and it is more suitable for use because the powder is less likely to solidify. However, other compositions can be applied. For example, the purity of MSM is 99.0% or more, the water content is 0.3% or less, the ash content is 0.2% or less, and 30 to 90 mesh can be used.

Next, AFA used Blue Green Algae manufactured by Klamath Valley Botanicals. When taken orally as a health food, the recommended daily intake is usually 1 to 1.5 g, but 1 g or less is sufficient when mixed with MSM and used transdermally as in the present invention. It is.
Table 6 shows the component contents and characteristics of the AFA powder.

  In Table 6, “appropriate” in penetrability means that it penetrates the skin smoothly when it is applied to the skin, and “appropriately fit” means that the degree of friction is somewhat. Large but can be used. In addition, the term “suitable” in terms of mixability means that general mechanical agitation is sufficient when mixing with MSM powder and natural jojoba oil, and “appropriately” means that even mechanical agitation requires time. Can be used, and “unsuitable” means that a long mechanical stirring is required.

  As shown in Table 6, the composition of (5) and (6) of AFA powder with 60 mesh and water content of 5 g or less is excellent in skin permeability and miscibility with other components, but other compositions are also applicable. Is possible. For example, nutrients are 60-70 g protein per 100 g, 15-25 g carbohydrates, 1-8 g lipids, 2-8 g vitamins and minerals, 1-5 g water, 30-90 mesh, and can be used. .

  In the examples, jojoba oil used was 100% pure natural product manufactured by Byholon Corporation. Moreover, the petrolatum of the Example used the Japanese Pharmacopoeia white petrolatum by Kenei Pharmaceutical Co., Ltd., and the olive oil used Bertoli pure olive oil from Italy. Moreover, the tape used for sticking in an Example is Nichiban Co., Ltd. battlewin serapore tape, 75 mm in width and 100 mm in length. In addition, the pasting type in an Example stuck what applied the half amount of the component by the mixing | blending of Table 4 to the affected part for about 12 hours. As a frequency of use per day, it is a guide to stick these two times.

  The above-described embodiments are merely examples of the anti-inflammatory agent in the present invention, and the components, the mixing ratios, the constituent materials / materials, and the processes are not limited to those described above.

The structure of a cell membrane. Explanatory drawing of the metabolic pathway of arachidonic acid involved in inflammation. Cell structure diagram of cyanobacteria (AFA). Explanatory drawing of the conversion process of sulfur containing MSM. The evaluation figure of the inflammation prevention and alleviation effect by the mixing ratio of MSM powder and AFA powder. The evaluation figure of the prevention and alleviation effect of inflammation by the mixing ratio of MSM powder and AFA powder (mixture) and natural jojoba oil, and absorption and penetration into the skin.

1 Cell membrane 2 Phospholipid 3 Constituent protein 4 Peripheral protein 5 Sugar chain 6 of peripheral protein Arachidonic acid 7 of cell membrane phospholipid 7 Release of arachidonic acid into the cytoplasm 8 Endoperoxide prostaglandins G2, H2
9 Prostaglandins I2, E2, F2
10 Inflammation, fever, pain 11 Thromboxane A2
12 Thrombus formation, asthma attack 13 5-HPTEE (5-hydroperoxyicosatetraene)
14 Leukotrienes A4, B4, C4, D4, E4
15 Inflammation, asthma attack 16 Cell wall 17 DNA
18 Sulfur 19 Dimethyl sulfide (DMS)
20 Dimethylsulfoxide (DMSO)
21 Dimethylsulfone (DMSO ₂ )
= Methylsulfonylmethane (MSM) and MSM formula A Application range of mixing ratio of MSM powder and AFA powder B Recommended range of mixing ratio of MSM powder and AFA powder C Weight ratio MSM powder 8 vs. AFA powder 2 point D Weight ratio MSM powder 6.7 to AFA powder 3.3 point E Weight ratio MSM powder 5 to AFA powder 5 point F Weight ratio MSM powder 2 to AFA powder 8 point G MSM powder and AFA powder (mixture) and natural Application range of jojoba oil mixing ratio H Recommended range of mixing ratio of MSM powder and AFA powder (mixture) and natural jojoba oil I Weight ratio Natural jojoba oil 8.3 vs. mixture 1.7 point J Weight ratio natural jojoba oil 8 Point K of mixture 2 Weight ratio 5 points of natural jojoba oil to point L of mixture 5 Weight ratio Point of natural jojoba oil 3.3 to point of mixture 6.7

Claims (8)

  Mixed powder containing natural methyl sulfonyl methane (MSM) powder and aphanizomenon floss aqua (AFA) powder in a certain ratio mixed in natural jojoba oil at a certain ratio, ointment or low viscosity An anti-inflammatory agent that can be applied to the skin of a living body.   The anti-inflammatory agent according to claim 1, wherein the mixing ratio of the methylsulfonylmethane (MSM) powder and the aphanizomenon furosqua (AFA) powder is 1 to 0.25 to 4 by weight ratio. .   Methylsulfonylmethane (MSM) powder is a white powder of at least 30 to 90 mesh derived from nature, has a methylsulfonylmethane (MSM) purity of 99.0% or higher, a melting point of 107 ° C or higher, and an ash content of 0 The anti-inflammatory agent according to claim 1 or 2, wherein the anti-inflammatory agent is 2% or less and water content is 0.3% or less.   Afanizomenon Floss Aqua (AFA) powder is at least a 30-90 mesh green powder of natural materials. Nutrients are 60-70 g protein per 100 g, 15-25 g carbohydrates, 1-8 g lipids, vitamins and minerals 3 to 8 g, chlorophyll a is 0.5 to 1.2 g, and the water content is 1 to 5 g.   Methylsulfonylmethane (MSM) powder and aphanizomenon floss aqua (AFA) powder were blended at a fixed ratio with 1 part by weight of natural jojoba oil to promote penetration and absorption into the skin through the body. The anti-inflammatory agent according to any one of claims 1 to 4, wherein the mixed powder is mixed and dispersed at a ratio of 0.2 to 2 parts by weight to form an ointment-like or low-viscosity mixture.   In order to facilitate the application to the skin of the living body, white petrolatum or olive oil is added to natural jojoba oil, methylsulfonylmethane (MSM) powder and aphanizomenon floss aqua (AFA) powder in a certain ratio. The anti-inflammatory agent according to any one of claims 1 to 5, which is mixed into an ointment.   A low-viscosity mixture of natural jojoba oil mixed with methylsulfonylmethane (MSM) powder and aphanizomenon floss aqua (AFA) powder in order to facilitate spraying the body through the skin. The anti-inflammatory agent according to any one of claims 1 to 5, wherein the anti-inflammatory agent is mixed in the LP gas propellant at a certain ratio to enable spraying.   Adhesive form of natural jojoba oil, methylsulfonylmethane (MSM) powder, and aphanizomenon floss aqua (AFA) powder mixed on a sticky surface of adhesive tape with elasticity, stretchability and breathability. The anti-inflammatory agent according to any one of claims 1 to 5, wherein the mixture prepared is arranged so that it can be attached to the skin of a living body.