JP2006282648A - Food composition for cosmetic purpose - Google Patents
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- JP2006282648A JP2006282648A JP2005130347A JP2005130347A JP2006282648A JP 2006282648 A JP2006282648 A JP 2006282648A JP 2005130347 A JP2005130347 A JP 2005130347A JP 2005130347 A JP2005130347 A JP 2005130347A JP 2006282648 A JP2006282648 A JP 2006282648A
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
本発明はアミノ酸の１種であるセリンを美容成分として配合することを特徴とする食品用組成物に関するものである。 The present invention relates to a food composition characterized in that serine, which is one of amino acids, is blended as a cosmetic ingredient.
従来、健康維持等の目的で食品用素材として研究されてきた各種のアミノ酸が、その特定成分又は特定の割合の組成物にすることにより、美容食品素材として利用できることが研究されている。例えば特開２００１−２２４３３４号公報では、Ｌ−プロリン、Ｌ−アラニン、Ｌ−グリシンを所定の割合で配合した美容食品が開示されている。当該公報開示の発明によれば、３種のアミノ酸を人肌コラーゲンに近い割合で飲食すると肌や髪の状態が改善することが報告され、具体的には、「肌のざらつき」、「かゆみ」、「しわ」、「シミ」、「くすみ」、「肌の乾燥」、「肌のつや」、「肌のはり」等の項目において、比較対照品よりも改善することがアンケート試験により示されている。また特開平２００４−０１３１２４号公報、特開２００５−０２９４８６号公報では、アミノ酸の配合が、メチルスルフォニルメタンやプロアントシアニジン等の他の有効成分の美容効果を促進することが開示されている。また特開２００４−３１５３８４号公報にはグリシン、スレオニン、ヒドロキシプロリン、アスパラギン酸またはそのアシル誘導体、および塩が美白効果を有し、食品として提供され得ることが開示されている。 It has been studied that various amino acids that have been studied as food materials for the purpose of maintaining health and the like can be used as beauty food materials by making the composition of a specific component or a specific ratio thereof. For example, Japanese Patent Application Laid-Open No. 2001-224334 discloses a beauty food in which L-proline, L-alanine, and L-glycine are blended at a predetermined ratio. According to the invention disclosed in the publication, it is reported that the condition of skin and hair is improved by eating and drinking three kinds of amino acids in a proportion close to that of human skin collagen. , “Wrinkles”, “stains”, “dullness”, “skin dryness”, “skin gloss”, “skin tension”, etc. showed by the questionnaire test that it is better than the comparative product Yes. Japanese Patent Application Laid-Open Nos. 2004-013124 and 2005-029486 disclose that the incorporation of amino acids promotes the cosmetic effect of other active ingredients such as methylsulfonylmethane and proanthocyanidins. Japanese Patent Application Laid-Open No. 2004-315384 discloses that glycine, threonine, hydroxyproline, aspartic acid or an acyl derivative thereof, and a salt have a whitening effect and can be provided as food.
しかしながら、美白効果を有し、さらに、皮膚水分量をも十分に増加させるような幅広い美容効果を有する単体のアミノ酸はまだ知られておらず、より美容効果の高いアミノ酸含有食品が望まれている。 However, a single amino acid having a whitening effect and a wide cosmetic effect that sufficiently increases skin moisture content is not yet known, and an amino acid-containing food with a higher cosmetic effect is desired. .
本発明は上記課題を解決すべく、アミノ酸を有効成分とし、より美容効果の高い食品用組成物を提供することを目的とする。 In order to solve the above-described problems, an object of the present invention is to provide a food composition having an amino acid as an active ingredient and having a higher cosmetic effect.
本発明者は、上記目的を達成すべく鋭意研究した結果、アミノ酸の１種であるセリンが美白および皮膚水分量増加という優れた美容効果を有していること見出し、当該セリンを美容成分として配合することにより本発明の食品用組成物を完成した。 As a result of earnest research to achieve the above object, the present inventor has found that serine, which is one of amino acids, has an excellent cosmetic effect of whitening and increasing skin moisture content, and blends the serine as a cosmetic ingredient. Thus, the food composition of the present invention was completed.
本発明のセリンはアミノ酸の１種の化合物であり、常法により得られるものである。食品添加物として市販されているＬ−セリンを購入して入手することもできる。さらに、セリンを食品用組成物中に適宜配合することにより、本発明の食品用組成物を得ることができる。食品用組成物の形態としては特に制限はなく、経口摂取できるものであれば、いずれの形態でもよい。例えば、粉末、顆粒、タブレット、チュアブル、カプセル、フィルム、キャンディー、グミ、飲料等が挙げられる。また、加工食品の原料（例えばタブレットの原材料物質）、調理又は飲食時に適宜添加するもの（例えば調味料）にすることもできる。 The serine of the present invention is a kind of amino acid compound and can be obtained by a conventional method. L-serine marketed as a food additive can also be purchased and obtained. Furthermore, the food composition of the present invention can be obtained by appropriately blending serine into the food composition. There is no restriction | limiting in particular as a form of a composition for foodstuffs, As long as it can be taken orally, any form may be sufficient. For example, powder, granule, tablet, chewable, capsule, film, candy, gummi, beverage and the like can be mentioned. Moreover, it can also be set as the raw material of processed foods (for example, the raw material substance of a tablet), what is added suitably at the time of cooking or eating and drinking (for example, a seasoning).
本発明の食品用組成物には美容成分として既に知られている食品素材を、本発明の目的を消失しない範囲で適宜配合することができる。例えば、コラーゲン、コラーゲン加水分解物、ビタミン群、核酸（ＤＮＡ）、杜仲葉エキス、高麗人参エキス、セリン以外のアミノ酸、ヒアルロン酸、コンドロイチン硫酸、セラミドなどが挙げられる。
また、本発明の食品組成物には食品として通常添加される成分を適宜配合することができる。例えば、果汁、甘味料、糖類、酸味料、香料、ｐＨ調整剤、増粘剤等が挙げられる。In the composition for food of the present invention, a food material already known as a cosmetic ingredient can be appropriately blended within a range not losing the object of the present invention. For example, collagen, collagen hydrolyzate, vitamin group, nucleic acid (DNA), chunaka leaf extract, ginseng extract, amino acids other than serine, hyaluronic acid, chondroitin sulfate, ceramide and the like.
In the food composition of the present invention, components usually added as food can be appropriately blended. For example, fruit juice, sweetener, saccharide, acidulant, fragrance, pH adjuster, thickener and the like can be mentioned.
本発明の食品用組成物中のセリンの配合量は特に制限されるものではないが、毎日摂取することが可能であるためには、１日の摂取量を１〜１００００ｍｇとすることがより好ましい。形態を錠剤、飲料にする場合、１日の摂取量を１〜１００００ｍｇとすることにより、より容易に本発明の食品組成物の製造・加工ができるからである。また、セリンの効果は美容を目的とするものであるが、より詳しくはセリンの美白効果に着目したもの又は皮膚水分量増加効果に着目したものとすることができる。セリンの美容効果は美白又は皮膚水分量増加を起因とするものであるからである。 The compounding amount of serine in the food composition of the present invention is not particularly limited, but in order to be able to take it every day, the daily intake is more preferably 1 to 10,000 mg. . It is because the food composition of the present invention can be produced and processed more easily by setting the daily intake to 1 to 10,000 mg when the form is tablets and beverages. The effect of serine is for cosmetic purposes, but more specifically, it can be focused on the whitening effect of serine or focused on the effect of increasing skin moisture. This is because the beauty effect of serine is caused by whitening or an increase in skin moisture.
以下、実施例により本発明を更に説明するが、本発明の技術的範囲はこれに限定されるものではない。 EXAMPLES Hereinafter, although an Example demonstrates this invention further, the technical scope of this invention is not limited to this.
実施例１（美容飲料１）
１本５０ｍｌ当りの配合量を、セリン：１００ｍｇ、コラーゲン：５ｇ、ビタミンＣ：５００ｍｇ、杜仲葉エキス：２２５ｍｇ、高麗人参エキス：７５ｍｇ、核酸（ＤＮＡ）：２００ｍｇ、Ｌ−アラニン：５０ｍｇ、Ｌ−オルニチン塩酸塩：５０ｍｇ、ビタミンＢ１：４ｍｇ、ビタミンＢ２：５ｍｇ、ビタミンＢ６：７ｍｇ、香料：適量、酸味料（クエン酸およびグルコン酸）：適量、精製水：メスアップ量（計５０ｍｌ）、として常法により美容飲料を作成した。１日１〜１０本程度摂取。Example 1 (beauty drink 1)
The blending amount per 50 ml is as follows: Serine: 100 mg, Collagen: 5 g, Vitamin C: 500 mg, Tochu Nakaba Extract: 225 mg, Ginseng Extract: 75 mg, Nucleic Acid (DNA): 200 mg, L-Alanine: 50 mg, L-Ornithine Hydrochloride: 50 mg, Vitamin B 1 : 4 mg, Vitamin B 2 : 5 mg, Vitamin B 6 : 7 mg, Fragrance: Appropriate, Acidulant (citric acid and gluconic acid): Appropriate, Purified water: Messup amount (total 50 ml), A beauty drink was prepared as usual. Take about 1 to 10 bottles a day.
実施例２（美容飲料２）
１本１００ｍｌ当りの配合量を、セリン：３ｇ、ビタミンＣ１ｇ、香料：適量、酸味料（クエン酸）：適量、精製水：メスアップ量（計１００ｍｌ）、として常法により美容飲料を作成した。１日１〜３本程度摂取。Example 2 (beauty drink 2)
A cosmetic beverage was prepared in a conventional manner with the amount per 100 ml of serine: Serine: 3 g, Vitamin C 1 g, Fragrance: Appropriate, Acidulant (citric acid): Appropriate, Purified water: Messup (total 100 ml). Take 1 to 3 bottles a day.
実施例３（美容飲料３）
１本９００ｍｌ当りの配合量を、セリン：９００ｍｇ、ビタミンＣ：９ｇ、コラーゲン：４５ｇ、香料：適量、酸味料（クエン酸およびリンゴ酸）：適量、防腐剤：適量、精製水：メスアップ量（計９００ｍｌ）、として常法により美容飲料を作成した。１日１０〜３０ｍｌ程度摂取。Example 3 (beauty drink 3)
The blending amount per 900 ml of one is serine: 900 mg, vitamin C: 9 g, collagen: 45 g, flavoring: appropriate amount, acidulant (citric acid and malic acid): appropriate amount, preservative: appropriate amount, purified water: mess up amount ( A total of 900 ml) was prepared as a beauty beverage by a conventional method. Take about 10-30 ml a day.
実施例４（タブレット１）
１錠３００ｍｇ当りの配合量を、セリン：２００ｍｇ、マルチトール：６０ｍｇ、セルロース：３０ｍｇ、ショ糖脂肪酸エステル１０ｍｇ、として常法によりタブレットを作成した。１日１〜１５錠程度摂取。Example 4 (Tablet 1)
Tablets were prepared by a conventional method with the blending amount per 300 mg of one tablet being serine: 200 mg, maltitol: 60 mg, cellulose: 30 mg, and sucrose fatty acid ester 10 mg. Take 1 to 15 tablets a day.
実施例５（タブレット２）
１錠約２０ｍｇ当りの配合量を、セリン：５ｍｇ、マルチトール：１０ｍｇ、セルロース：５ｍｇ、香料：適量、として常法によりタブレットを作成した。１日１〜５０錠程度摂取。Example 5 (Tablet 2)
Tablets were prepared by a conventional method with the blending amount per tablet of about 20 mg as serine: 5 mg, maltitol: 10 mg, cellulose: 5 mg, and fragrance: appropriate amount. Take 1-50 tablets a day.
実施例６（カプセル）
１カプセル当りの配合量を、セリン：５０ｍｇ、乾燥でんぷん：１５０ｍｇとして、ゼラチンをカプセル原料として、常法によりハードカプセルを作成した。１日１〜１８カプセル程度摂取。Example 6 (capsule)
Hard capsules were prepared in a conventional manner using a blending amount per capsule of serine: 50 mg and dry starch: 150 mg, and gelatin as a capsule raw material. Take 1 to 18 capsules a day.
試験例１
セリンの美白効果を検証するため、動物の経口摂取による皮膚色素沈着抑制試験を実施した。
（方法）
セリンを通常のモルモット飼料に適量添加し、セリンが０．１６７重量％配合するモルモット飼料を作成した。ネガティブコントロールとして通常のモルモット飼料を使用した。また、ポジティブコントロールとして美白成分として知られているシステイン（特開２００４−２０３８１２号公報に開示）が０．２６７重量％配合するモルモット飼料を作成し、使用した。
茶色モルモット（ウェルターメイプル種）１群７匹のモルモットのそれぞれの群に試験飼料、又は比較対照飼料（ネガティブコントロール、ポジティブコントロール）を自由摂取にて２８日間与えた後、背部を剃毛して紫外線（ＵＶＢ強度：１Ｊ／ｃｍ２）を、隔日で計３日間照射し、色素沈着の作成を行った。紫外線照射期間および照射後それぞれの群にさらに試験飼料、又は比較対照飼料を自由摂取にて与え、紫外線照射前および紫外線照射後４、７、１４、２１、２８、３５日後の色素沈着を以下に示す判定基準にしたがって肉眼判定した。また同時に、色彩色差計（ＭＩＮＯＬＴＡ製ＣＲ−２００）を用いて色素沈着部位の明度差（試験前後のＬ値）を測定した。各群の色素沈着度（％）は、照射後のＬ値と照射前のＬ値の差を求め、ネガティブコントロールにおいて最も色素沈着した値（３５日後）を１００％として算出した。
（色素沈着の判定基準）
−；色素沈着が認められない、±；わずかな色素沈着が認められる、＋；中等度の色素沈着が認められる、＋＋；強度の色素沈着が認められる
（結果）
表１に示すように、セリンを配合した飼料は皮膚色素沈着抑制効果を示した。Test example 1
In order to verify the whitening effect of serine, a skin pigmentation inhibition test by ingestion of animals was conducted.
(Method)
An appropriate amount of serine was added to normal guinea pig feed to prepare a guinea pig feed containing 0.167% by weight of serine. A normal guinea pig feed was used as a negative control. Moreover, the guinea pig feed which cysteine (disclosed in Unexamined-Japanese-Patent No. 2004-203812) known as a whitening component as a positive control mix | blends 0.267 weight% was created and used.
Brown guinea pigs (welter maple species) Each group of seven guinea pigs was given a test diet or a comparative control diet (negative control, positive control) for 28 days with free ingestion, and then the back was shaved and UV light was applied. (UVB intensity: 1 J / cm 2 ) was irradiated every other day for a total of 3 days to prepare pigmentation. The test feed or comparative control feed is further given to each group after the UV irradiation period and after irradiation, and the pigmentation after 4, 7, 14, 21, 28 and 35 days before and after UV irradiation is as follows: The naked eye was judged according to the criteria shown. At the same time, the brightness difference (L value before and after the test) of the pigmentation site was measured using a color difference meter (CR-200 manufactured by MINOLTA). The degree of pigmentation (%) in each group was calculated by determining the difference between the L value after irradiation and the L value before irradiation, and setting the most pigmented value (after 35 days) in the negative control as 100%.
(Criteria for pigmentation)
-; No pigmentation is observed; ±; slight pigmentation is observed; +; moderate pigmentation is observed; ++; intense pigmentation is observed (result)
As shown in Table 1, the feed containing serine showed a skin pigmentation inhibitory effect.
試験例２
セリンの皮膚水分量増加効果を検証するため、動物の経口摂取による皮膚水分量増加試験を実施した。
（方法）
セリンを通常のモルモット飼料に適量添加し、セリンが０．１６７重量％配合するモルモット飼料を作成した。コントロールとして通常のモルモット飼料を使用した。１群７匹の茶色モルモット（ウェルターメイプル種）のそれぞれの群に試験飼料、又は比較対照飼料（コントロール）を自由摂取にて与え、飼料摂取後６８日後の皮膚水分量を皮膚水分計（ｃｏｕｒａｇｅ＋ｋｈａｚａｋ製ｃｕｍｅｏｍｅｔｅｒ ＣＭ８２５）にて測定した。皮膚水分量（％）をコントロール群の皮膚水分量を１００％として算出した。
（結果）
表２に示すように、Ｌ−セリンが配合した飼料は皮膚水分量増加効果を示した。Test example 2
In order to verify the effect of serine on increasing the amount of skin moisture, a test for increasing the amount of skin moisture by oral ingestion of animals was conducted.
(Method)
An appropriate amount of serine was added to normal guinea pig feed to prepare a guinea pig feed containing 0.167% by weight of serine. A normal guinea pig feed was used as a control. Each group of 7 brown guinea pigs (welter maple species) was given a test feed or a comparative control feed (control) by free intake, and the skin moisture content 68 days after the intake of the feed was made by a skin moisture meter (courage + khazak) measurement with a CMometer CM825). The skin moisture content (%) was calculated with the skin moisture content of the control group as 100%.
(result)
As shown in Table 2, the feed containing L-serine showed an effect of increasing the skin moisture content.
試験例３
セリンの美白効果を検証するため、メラニン産生色素細胞（Ｂ１６ ｍｏｕｓｅ Ｍｅｌａｎｏｍａ）に対する白色化効果を試験した。
（方法）
クリーンベンチ内において培養フラスコ（２５ｃｍ２）に、牛胎児血清１ｍｌ、イーグル最少栄養培地９ｍｌを添加し、そこに３×１０４個の色素細胞（Ｂ１６ ｍｏｕｓｅ Ｍｅｌａｎｏｍａ）をまき、炭酸ガス培養器において５％の炭酸ガスを含有する空気下３７℃で培養した。細胞が付着したところで、フラスコに試料を、各々最終濃度が５０μｇ／ｍｌ、１００μｇ／ｍｌになるように添加し、３日間培養した。比較例としてアミノ酸の１種であるアラニン、ロイシン、プロリンを使用した。なお、ネガティブコントロールは試料を添加せず培養したものを使用した。また、ポジティブコントロールとして、既に本試験系において白色化することが知られているブドウ種子エキスを使用した。３日間培養した色素細胞を顕微鏡観察した後、培養液を除去し、０．０２％ＥＤＴＡ（エチレンジアミン テトラアセテート）、次いで０．２５％トリプシンを含むダルベッコのリン酸緩衝液を加え剥離した。次いで、剥離した色素細胞にリン酸緩衝液９ｍｌを加え、１０００ｇで５分間遠心して得られた色素細胞の細胞ペレットにより白色化の程度を肉眼により比較した。
（結果）
表３に示すように、セリンにおいて色素細胞の白色化効果が確認された。なお、いずれの系も細胞毒性がないことを肉眼、および細胞数計測で確認した。Test example 3
In order to verify the whitening effect of serine, the whitening effect on melanin producing pigment cells (B16 mouse Melanoma) was tested.
(Method)
In a clean bench, 1 ml of fetal bovine serum and 9 ml of Eagle's minimal nutrient medium were added to a culture flask (25 cm 2 ), and 3 × 10 4 pigment cells (B16 mouse Melanoma) were seeded there. The cells were cultured at 37 ° C. in air containing% carbon dioxide. When the cells adhered, the sample was added to the flask so that the final concentrations were 50 μg / ml and 100 μg / ml, respectively, and cultured for 3 days. As a comparative example, alanine, leucine and proline which are one kind of amino acids were used. In addition, the negative control used what was cultured without adding a sample. As a positive control, a grape seed extract already known to be whitened in this test system was used. After observing the pigment cells cultured for 3 days under a microscope, the culture solution was removed, and 0.02% EDTA (ethylenediamine tetraacetate) and then Dulbecco's phosphate buffer containing 0.25% trypsin were added and detached. Next, 9 ml of a phosphate buffer was added to the detached pigment cells, and the degree of whitening was compared with the naked eye using pigment cell pellets obtained by centrifugation at 1000 g for 5 minutes.
(result)
As shown in Table 3, the whitening effect of pigment cells was confirmed in serine. In addition, it was confirmed by naked eye and cell number measurement that none of the systems was cytotoxic.
試験例４
セリンの美容効果を検証するため、ヒトによる飲用試験を実施した。
（方法）
実施例１の美容ドリンクを１日１本、３５歳以上の女性１４名に連続１０日間飲用してもらい、飲用前との比較において飲用後の美容実感をアンケートした。
（結果）
肌の状態について飲用前後の違いを７段階で評価したところ、表４に示すように、１４人中９人以上が、飲用前よりも「少し良くなった」以上を回答した。また、肌の状態がどのように改善したかとの回答を求めたところ、表５の結果が得られた。
以上のようにセリンを配合した実施例１のドリンクの美容効果が示された。Test example 4
In order to verify the beauty effect of serine, a human drinking test was conducted.
(Method)
The beauty drink of Example 1 was taken once a day, and 14 women aged 35 years or older were drunk for 10 consecutive days, and the beauty after drinking was surveyed in comparison with before drinking.
(result)
When the difference between before and after drinking was evaluated with respect to the skin condition in 7 stages, as shown in Table 4, 9 or more out of 14 responded that “it was a little better” than before drinking. Moreover, when the reply of how the skin state improved was calculated | required, the result of Table 5 was obtained.
As described above, the cosmetic effect of the drink of Example 1 containing serine was shown.
本発明の食品用組成物は、美白および皮膚水分量増加という優れた美容効果を有する。 The food composition of the present invention has excellent cosmetic effects such as whitening and increased skin moisture.
Claims (4)
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2014003154A1 (en) * | 2012-06-29 | 2014-01-03 | 協和発酵バイオ株式会社 | Agent for preventing deterioration in vascular endothelial function or improving vascular endothelial function |
| JP2015137249A (en) * | 2014-01-22 | 2015-07-30 | 株式会社ファンケル | Winter depression remedy |
| JP2015188373A (en) * | 2014-03-28 | 2015-11-02 | 株式会社ファンケル | Granule |
| JP2021045110A (en) * | 2019-09-20 | 2021-03-25 | 株式会社桃谷順天館 | Composition for improving skin quality |
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2005
- 2005-03-31 JP JP2005130347A patent/JP2006282648A/en not_active Withdrawn
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014003154A1 (en) * | 2012-06-29 | 2014-01-03 | 協和発酵バイオ株式会社 | Agent for preventing deterioration in vascular endothelial function or improving vascular endothelial function |
| US20150141514A1 (en) * | 2012-06-29 | 2015-05-21 | Kyowa Hakko Bio Co., Ltd. | Agent for preventing deterioration in vascular endothelial function or improving vascular endothelial function |
| JPWO2014003154A1 (en) * | 2012-06-29 | 2016-06-02 | 協和発酵バイオ株式会社 | Preventive or ameliorating agent for vascular endothelial function decline |
| US9833426B2 (en) | 2012-06-29 | 2017-12-05 | Kyowa Hakko Bio Co., Ltd. | Agent for preventing deterioration in vascular endothelial function or improving vascular endothelial function |
| JP2015137249A (en) * | 2014-01-22 | 2015-07-30 | 株式会社ファンケル | Winter depression remedy |
| JP2015188373A (en) * | 2014-03-28 | 2015-11-02 | 株式会社ファンケル | Granule |
| JP2021045110A (en) * | 2019-09-20 | 2021-03-25 | 株式会社桃谷順天館 | Composition for improving skin quality |
| JP7449060B2 (en) | 2019-09-20 | 2024-03-13 | 株式会社桃谷順天館 | Composition for improving skin quality |
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