JP2006035132A - Method for producing solid particles using microchannel structure and display capsule obtained thereby - Google Patents

Abstract

Disclosed is a method for producing solid particles by gelling or encapsulating while maintaining the degree of dispersion of droplets obtained at the intersection of a continuous phase and a dispersed phase of a microchannel structure. Provided is a capsule production method that does not impair the movement of particles.
An inlet and an introduction channel for introducing a dispersed phase, an inlet and an introduction channel for introducing a continuous phase, and particles generated through the dispersed phase and the continuous phase are discharged. A method for producing solid particles using a microchannel structure having a discharge channel and a discharge port for supplying a fluid in which a part of the fluid is previously made into an oligomer and / or polymer, A method for producing solid particles in which droplets are generated and a film is formed on the surface of the droplets, and then the film is cured by an unreacted component, and a display capsule obtained thereby are used.
[Selection figure] None

Description

  The present invention relates to a method for producing solid particles such as gels and microcapsules having a uniform particle diameter. In particular, the present invention relates to a microcapsule that can be used for display using magnetophoresis or electrophoresis microcapsules.

  In recent years, a fluid is introduced into a microchannel using a microchannel structure having a microchannel having a length of about several centimeters on a glass substrate of several cm square and a width and depth of sub mm to several hundred mm. Research has been attracting attention for the generation of droplets by introducing two types of liquids having different interfacial tensions into a microscopic droplet by introducing them into a channel where the intersection of the two types of fluids exists. Can be prepared (see, for example, Patent Document 1 or Non-Patent Document 1). The emulsion here refers to a system in which one of two insoluble liquids is dispersed as fine particles in the other liquid.

  For example, the technique disclosed in Patent Document 1 or Non-Patent Document 1 has a continuous phase inlet (2) in the substrate (1) as shown in FIG. 2 and FIG. 2 showing the AA ′ cross section in FIG. ), A flow path for introducing a continuous phase (hereinafter referred to as a continuous phase introduction flow path (3)), a dispersed phase introduction port (4), and a flow path for introducing a dispersed phase (hereinafter referred to as a dispersed phase introduction flow path (5)). ), A T-shaped channel having a channel (hereinafter referred to as a discharge channel (7)) for discharging the dispersed phase formed into droplets in the continuous phase and a discharge port (8), and the flow of the substrate It is a micro flow channel structure in which a cover body is joined to the road surface side, and with respect to the continuous phase flowing in the microchannel, the dispersed phase is discharged from the dispersed phase supply port in a direction crossing the flow of the continuous phase, and the continuous phase Due to the shearing force, fine droplets having a diameter smaller than the width of the supply channel of the dispersed phase are obtained. However, in this method, the obtained droplets contain minute droplets, and it has been difficult to gel or microencapsulate uniform droplets while maintaining the same degree of dispersion.

International Publication WO02 / 068104 Pamphlet Takashi Nishisako et al., “Liquid microdroplet generation in microchannels”, Proceedings of the 4th Chemistry and Microsystem Study Group, 59 pages, 2001

  In the gelation and encapsulation of the emulsion obtained through the microchannel structure, the gelation is performed by heating while stirring in the structure having a stirring mechanism as conventionally used. However, there was a problem that the dispersibility deteriorated due to re-division and coalescence by stirring during gelation. In addition, the method of polymerizing in the discharge flow path in which the droplets are generated has problems such as the flow path being clogged and insufficient gelation and encapsulation. Furthermore, there is a problem that the internal microparticles adhere to the wall of the encapsulated fine particles and the free movement inside is hindered, and an optimal method has been desired.

  The present invention has been made in view of the above-mentioned problems. The solid state is obtained by gelling or encapsulating while maintaining the degree of dispersion of the droplets obtained at the continuous phase and dispersed phase intersection of the microchannel structure. An object of the present invention is to provide a method for producing particles, a method for producing solid particles that do not impair movement of microparticles in the capsule, and a display capsule obtained thereby.

  The present invention is to introduce an inlet and an introduction channel for introducing a dispersed phase, an introduction port and an introduction channel for introducing a continuous phase, and particles generated through the dispersed phase and the continuous phase. A method for producing solid particles using a micro-channel structure having a discharge channel and a discharge port, wherein a fluid in which a part of the fluid is converted into an oligomer and / or polymer in advance is sent to the liquid This is a method for producing solid particles in which droplets are formed, a film is formed on the surface of the droplets, and then the film is cured by an unreacted component, and is suitable for producing capsules as solid particles. Further, fine particles may be contained in the dispersed phase to be fed in advance.

  Furthermore, the present invention relates to a method for producing solid particles containing a surfactant in a fluid in which a part of the continuous phase or dispersed phase is previously oligomerized or polymerized, and a film that covers the surface of the droplets in advance. The solid phase particle or oligomer polymer is contained in the continuous phase, and the coating phase oligomer or polymer that covers the surface of the droplets in advance is substantially included in the dispersed phase. It is a manufacturing method of the solid particle which is not.

  The present invention introduces a dispersed phase that does not contain monomers, oligomers or polymers of the raw material of the capsule film into a continuous phase in which a part of the raw material of the capsule film is made into an oligomer or polymer in advance, and prepares a droplet and capsule film And then the film is cured with unreacted monomers and a crosslinking agent in the continuous phase while being fed in a thin tube, and the dispersion is carried out in advance. Fine particles may be contained in the phase.

  The present invention is also a method for producing solid particles in which the capsule containing fine particles is for display using a magnetophoresis or electrophoresis microcapsule, and the liquid in the capsule may be colored. .

  The present invention also provides a capsule for display obtained by a method for producing solid particles, the dispersion of which is 3% or less.

  Hereinafter, the present invention will be described in more detail.

  The micro channel used in the present invention generally indicates a channel having a width of 500 mm or less and a depth of 300 mm or less, and the micro channel may be called a micro channel. In the following, the microchannel defined as described above and the channel having a width and depth larger than the microchannel may be collectively referred to as a channel. The discharge channel is substantially continuous with the continuous phase introduction channel, and the discharge channel exists as an extension of the continuous phase introduction channel.

  In the present invention, the dispersed phase introduction flow path is limited to being a microchannel, but the continuous phase introduction flow path is not particularly limited to a microchannel, and may be a microchannel or not a microchannel. May be. Therefore, the discharge flow path substantially continuous with the continuous phase introduction flow path is not limited to the microchannel, and the discharge flow path may be a microchannel or not a microchannel. Rather, in order to improve the particle size dispersion of the gel or capsule, which is the object of the present invention, as described later, it is preferable that the continuous phase introduction flow path and the discharge flow path are not microchannels. More preferably not.

  The emulsion in the present invention is a suspension containing fine droplets generated from a dispersed phase in a continuous phase.

  The dispersed phase and the continuous phase used in the present invention are liquid materials for generating droplets and are liquids that are not compatible with each other. Among these, the continuous phase is used for shearing the dispersed phase to generate droplets. For example, a medium in which a dispersant such as polyvinyl alcohol is dissolved in a suitable solvent, a medium containing a surfactant such as sodium dodecyl sulfate or poly (ethylene-alt-maleic anhydride) (poly (EMA)), It refers to a raw material for forming a gel or capsule, a medium with adjusted pH, and the like.

  The dispersed phase is a fluid that is dispersed in a continuous phase to form droplets, and finally forms part or the whole of a gel or capsule, and is a medium such as dodecane or one or more types of titania powder. It refers to a medium containing fine particles, a dyed medium such as Oil Blue N, a medium containing a surfactant, a raw material for forming a gel or a capsule, or a medium in which pH is adjusted.

  Here, a liquid partially made of an oligomer or a polymer and a liquid that is not compatible with this partially block the microchannel in order to adjust the droplets to a uniform size by feeding the microchannel. It is necessary to have fluidity to the extent that it does not. The liquid in which a part of the oligomer or polymer is previously formed is heated in the microchannel and before the portion where the dispersed phase channel and the continuous phase channel meet by heating, light irradiation, etc. It may be a liquid containing. For example, when an aqueous phase is used as the dispersed phase, an organic phase such as dodecane that does not substantially dissolve in water is used as the continuous phase. Moreover, the reverse is true when an aqueous phase is used as the continuous phase.

  In the microchannel, the dispersed phase is dispersed in the continuous phase after the junction where the dispersed phase channel and the continuous phase channel are merged, and the gel or capsule coating that has become an oligomer or polymer in advance. It becomes the droplet which formed the film with this raw material.

  The droplets generated in the microchannel are the shape of the intersection of the microchannels and the discharge channel, the viscosity and interfacial tension of the continuous phase and dispersed phase to be sent, and the speed of the fluid to be sent to the microchannel The size can be controlled by means of the microchannel wall surface and the dispersed phase flow at the place where the tip of the dispersed phase that has moved as a liquid column in the flow channel joins the continuous phase. A uniform shearing force is applied to form droplets of uniform size.

  The micro-channel discharge part after droplet formation forms a film and the coalescence and splitting are suppressed, but it is wider than the droplet generation part in order to reduce the influence from the wall surface Is desirable.

  At the time of droplet formation, unreacted monomers, oligomers and polymers are present in the liquid. By heating and irradiating the emulsion containing droplets generated after droplet formation, these are used as raw materials. By doing so, it is finally possible to obtain a strong gel or capsule.

  Here, the surfactant is incorporated into the oligomer or polymer by forming a part of the liquid into an oligomer or polymer, and the film formation is promoted at the interface between the continuous phase and the dispersed phase. The At this time, if the surfactant is a polymer having a large molecular weight, it is easy to efficiently promote formation of an interface film of the oligomer or polymer droplets. Furthermore, when the surfactant is polymerized and taken in with the raw material for forming the film, the film formation is further promoted.

  In this way, even when the dispersed phase becomes droplets of a uniform size in the continuous phase in the microchannel and at the same time a film is formed, and then completely gelled or encapsulated, it is also formed at the time of droplet generation The coated film suppresses the coalescence and breakage of the droplets, and can be cured into a gel or a capsule with a small particle size distribution at the time of droplet generation.

  In addition, by including in the continuous phase the material of the gel or capsule film that has become an oligomer or polymer in advance, the substance to be encapsulated inside the droplet is formed into droplets with the composition desired to be encapsulated without mixing with the capsule film material, It becomes possible to encapsulate.

  In addition, since the influence of gravity is smaller in the microchannel than the influence of interfacial tension and viscous force, it is possible to detach from the droplet when enclosing fine particles with a specific gravity different from that of the liquid in the dispersed phase. Is small and can be efficiently taken into the droplet. In addition, when curing the droplets, the particles taken into the droplets are heated so that the unreacted monomers, oligomers, and polymers contained only in the continuous phase are not heated in the dispersed phase. Since the coating is formed on the outer surface of the droplet by irradiation with light or light, it is possible to prevent the particles inside the droplet from being taken in and fixed in the coating.

  The capsule enclosing the fine particles thus produced can be a display or recording capsule intended to move the internal particles in response to external electricity or magnetism. For example, capsules containing magnetic fine particles or positively or negatively charged fine particles such as titania or carbon powder do not adhere to the film and can move freely in response to external stimuli. The signal ratio when not displayed can be increased. In addition, since the dispersion degree of the capsule is small, it is possible to arrange the capsules at a high density on a plane, and to perform a fine display. In addition, color display is also possible by including different colors in each capsule and displaying or not displaying them.

  In the method for producing a gel or capsule of the present invention, examples of the use of the gel or capsule include a high-performance liquid chromatography column filler, pressure measurement film, carbonless (pressure-sensitive copying) paper, toner, thermal expansion agent, and heat medium. , Light control glass, gap agent (spacer), thermochromic (thermosensitive liquid crystal, thermosensitive dye), magnetophoresis capsule, pesticide, artificial feed, artificial seed, fragrance, massage cream, lipstick, vitamin capsule, activated carbon Examples include enzyme capsules, microcapsules such as DDS (drug delivery system), and gels.

  The microchannel structure used in the present invention has the above-described structure and performance, but the introduction part for introducing the dispersed phase and the continuous phase, the introduction channel, and the intersection where the introduction channel intersects. And a micro-channel structure having a discharge channel and a discharge port for discharging the liquid so as to cover the substrate having the channel formed on at least one surface and the substrate surface having the channel formed thereon. In addition, a cover body in which a small hole for communicating the flow channel and the outside of the micro flow channel structure may be laminated and integrated at a predetermined position of the flow channel. As a result, the fluid can be introduced from the outside of the microchannel structure into the channel and discharged again to the outside of the microchannel structure, and the fluid can be stably flowed even if the amount of fluid is small. It is possible to pass through the road. The fluid can be fed by mechanical or physical means such as a syringe pump, a micro pump, or pressurized fluid feeding.

  As the material of the substrate and the cover body on which the flow path is formed, it is desirable that the flow path can be formed, has excellent chemical resistance, and has an appropriate rigidity. For example, glass, quartz, ceramic, silicon, or metal or resin may be used. The size and shape of the substrate and cover body are not particularly limited, but the thickness is preferably about several mm or less. The small hole arranged in the cover body communicates the flow channel and the outside of the micro flow channel structure and has a diameter of, for example, about several hundred mm to several mm when used as a fluid inlet or outlet. It is desirable. The small holes in the cover body can be processed chemically, mechanically, or by various means such as laser irradiation or ion etching.

  In the microchannel structure of the present invention, the substrate on which the channel is formed and the cover body can be laminated and integrated by means such as heat bonding or bonding using an adhesive such as a thermosetting resin.

  Moreover, the structure of the solidified part can be produced and processed by the same means as the microchannel structure, but an existing tube or container may be used.

  The gel or capsule production apparatus of the present invention comprises an introduction port for introducing a dispersed phase and a dispersed phase introduction channel, an introduction port for introducing a continuous phase and a continuous phase introduction channel, and a dispersed phase and a continuous phase. A microchannel structure having a discharge channel and a discharge port for discharging the generated liquid droplets is supplied to a fluid partially made into an oligomer or polymer in advance. Then, by forming a surface film at the same time as generating droplets, and then curing the film with unreacted monomer or crosslinking agent, coalescence of the droplets can be suppressed. Can be obtained.

  Examples of the present invention will be described below, and the embodiments of the present invention will be described in more detail. It is needless to say that the present invention is not limited to the following examples and can be arbitrarily changed without departing from the gist of the present invention.

  The microchannel according to the first embodiment of the present invention is shown in FIGS. 3 and 4 which are L-L 'sectional views and FIG. 5 which is an M-M' sectional view in FIGS. On a Pyrex (registered trademark) glass of 70 mm × 20 mm × 1 t (thickness), a dispersed phase corresponding to a continuous phase introduction channel (3) having a width of 170 μm and a depth of 69 μm, and a microchannel having a width of 137 μm and a depth of 69 μm The introduction channel (5) is a discharge channel (7) having a width of 170 μm, a depth of 69 μm and a length of 40 mm, and the continuous phase introduction channel (3) and the dispersed phase introduction channel (5) are at an angle of 44 °. A substrate (1) on which one Y-shaped channel having an intersecting portion intersecting with each other was formed.

  As shown in FIG. 6, the microchannel structure having the channel is formed on one surface of a glass substrate having a thickness of 1 mm and a size of 70 mm × 20 mm by a general photolithography and wet etching. A small hole having a diameter of 1.2 mm is formed in advance on the surface of the substrate (1) having the flow path at positions corresponding to the introduction port (11) and the discharge port (8) of the flow path using mechanical processing means. A provided glass cover body (16) having a thickness of 1 mm and a size of 70 mm × 20 mm was thermally bonded.

  Next, the fine particle manufacturing method of the present embodiment will be described. As shown in FIG. 7, a holder (11) or the like is used so that liquid can be fed to the microchannel structure (10), and the Teflon (registered trademark) tube (14) and fillet joint (18) are attached to the holder. To fix. The other end of the Teflon tube is connected to the microsyringe (20). Thus, liquid can be fed to the microchannel structure. In addition, a Teflon (registered trademark) tube (15) having an inner diameter of 500 μm and a diameter of 10 m was connected to the tip of the discharge side Teflon (registered trademark) in a heating container.

  Next, dodecane and Oil Blue N are used as a dispersed phase for generating microdroplets, and 3.3 wt% poly (E-MA), 3.3 wt% urea, and 0.33% resorcinol are used as pure water in a continuous phase. 75 g of a 0.07 wt% aqueous solution was adjusted to pH 3.50 with 1N NaOH. To 3 g of this aqueous solution, 0.25 g of formaldehyde aqueous solution was heated and stirred at 75 ° C. for 20 minutes until the aqueous phase became cloudy, and this was used as a dispersed phase. At this time, the transparency of the aqueous phase was about 4%, which was such that the other side was not visible through the 1 ml syringe. The viscosity was about 4 mPa · s. From this, it is understood that at least a part of the aqueous phase as a fluid was oligomerized or polymerized by heating at 75 ° C. for 20 minutes.

  Next, an aqueous phase as a continuous phase and an organic phase as a dispersed phase were injected into each microsyringe, and liquid feeding was performed with a microsyringe pump (19). The liquid feeding speed is 5 μl / min and 50 μl / min for the dispersed phase and the continuous phase, respectively. Formation of microdroplets was observed at the intersection where the disperse phase and continuous phase of the microchannel structure intersect, with both the liquid feed rates stable. When the generated microdroplets were observed, they were uniform microdroplets having an average particle size of 106 μm and a CV value (%) of 1.6% indicating the particle size dispersion as shown in FIG.

  The emulsion solution containing the fine droplets was fed into a Teflon (registered trademark) tube having an inner diameter of 500 μm and a diameter of 10 m, which was allowed to stand in a container heated to 50 ° C., to obtain a discharge port (16) microcapsule.

  When the obtained microcapsules were observed, there was no aggregation, and as shown in FIG. 9, the microcapsules with a uniform urea / formalin resin coating with a mean particle size of 107 μm and a dispersity of 1.35% were contained. there were.

  As shown in Example 1, the microcapsule fine particles encapsulated in the liquid without substantially deteriorating the dispersibility by heating the coating film or capsule raw material to be an oligomer or polymer in advance. Can now be made.

  The same microchannel and heating container as those in Example 1 were used in the comparative example. Although the liquid was sent in the same manner as in Example 1, the aqueous phase, which is a continuous phase containing the film raw material, was not heat-treated. The liquid feeding speed is 5 μl / min and 50 μl / min for the dispersed phase and the continuous phase, respectively, as in Example 1. Formation of microdroplets was observed at the intersection where the disperse phase and continuous phase of the microchannel structure intersect, with both the liquid feed rates stable.

  When the generated microdroplets were observed, as shown in FIG. 13, the CV value (%) indicating an average particle size of 108 μm and a particle size dispersion degree was 3.1% and uniform. The emulsion solution containing the fine droplets was fed into a Teflon (registered trademark) tube having an inner diameter of 500 μm and a diameter of 10 m, which was allowed to stand in a container heated to 50 ° C., to obtain a discharge port (16) microcapsule.

  When the obtained microcapsules were observed, aggregated capsules and non-aggregated capsules were formed as shown in FIG. The average particle size of the capsules without agglomeration was 111 μm and a microcapsule of urea / formalin resin film having a dispersity of 8.5%.

  As shown in Comparative Example 1, when the coating film or capsule material to be fed is fed without using an oligomer or polymer, the droplets generated in the microchannels are collected at the same time as the degree of dispersion substantially deteriorates during curing. The rate was reduced.

  The microchannel in the second example of the present invention was the same as that in Example 1. In the same manner as in Example 2, the solution was sent, but in a dispersed phase for producing microdroplets, a blue dye Oil Blue N 1.3 wt% was dissolved in 90.5 wt% of Isopar G solution, titania (DuPont). A product obtained by dissolving 3.2 wt% of an oil-soluble dispersion stabilizer and 5.0 wt% of an oil-soluble dispersion stabilizer, and dispersing well by ultrasonic vibration was used.

  As the continuous phase, one prepared in the same manner as in Example 1 was used. The dispersed phase and the continuous phase were each injected into a microsyringe, and the solution was fed with a microsyringe pump (19). The liquid feeding speed is 5.0 μl / min and 100 μl / min for the dispersed phase and the continuous phase, respectively.

  Formation of microdroplets was observed at the intersection where the dispersed phase channel and the continuous phase channel intersect in the microchannel structure with both the liquid feeding speeds stabilized. When the generated microdroplets were observed, as shown in FIG. 12, the CV value (%) indicating an average particle size of 70 μm and a particle size dispersion degree was 3.4% and uniform. The emulsion solution containing these microdroplets was heated to 50 ° C. By this heating, the transparency of the aqueous phase was about 4%, which was such that the other side was not visible through the 1 ml syringe. The viscosity was about 4 mPa · s. From this, it can be seen that at least a part of the microdroplet, which is a fluid, was oligomerized or polymerized by heating at 50 ° C.

  The emulsion solution containing the fine droplets was fed into a Teflon (registered trademark) tube having an inner diameter of 500 μm and a diameter of 10 m, which was allowed to stand in a container heated to 50 ° C., to obtain a discharge port (16) microcapsule.

  When the obtained microcapsules were observed, there was no aggregation, and as shown in FIG. 13, a uniform urea / formalin resin coating containing titania having an average particle size of 70 μm and a dispersion degree of 2.5% containing a dodecane solution inside. It was a microcapsule.

  In addition, the prepared microcapsules were added dropwise to a glass on which an ITO thin film was formed in a state of being dispersed in water and dried to prepare a cell sandwiched between another ITO film-formed glass. A voltage of 400 V (1.0 Hz) was applied to the produced cell, and the color change due to the fine particles in the capsule was confirmed. As shown in FIG. 14, a uniform white display was confirmed during white display.

  In addition, as shown in FIG. 15, when a blue color is displayed, comparing the capsule produced without using the microchannel and the outline of the capsule, the particles produced without using the microchannel as shown in FIG. In contrast to the fact that a white shade can be confirmed in the outline portion, the fine particles inside the capsule according to Example 2 are easy to move without being bound by the capsule film, as seen in the capsule produced in Example 2. A fine particle-encapsulating capsule could be produced.

  Capsule preparation in the second comparative example of the present invention was carried out by using titania (manufactured by DuPont) 3 in 90.5 wt% of Isopar G solution in which 1.3 wt% of blue dye Oil Blue N similar to that of Example 2 was dissolved in the dispersed phase. .2 wt% and oil-soluble dispersion stabilizer solsperse 5.0 wt% were dissolved and dispersed well by ultrasonic vibration. In addition, 75 g of an aqueous solution of 3.3 wt% poly (E-MA), 3.3 wt% urea, 0.33% wt resorcinol, and 93.07 wt% pure water was adjusted to pH 3.50 with 1N NaOH to 3 g of this aqueous solution. 0.25 g of formaldehyde aqueous solution was added to form a continuous phase.

  This was heated at 50 ° C. for 3 hours while being suspended using a stirring blade to obtain microcapsules. Similarly to Example 2, the produced microcapsules were dropped on the glass on which the ITO thin film was formed in a state of being dispersed in water, and dried to produce a cell sandwiched between the other ITO-formed glass. .

  A voltage of 400 V (1.0 Hz) was applied to the produced cell, and the color change due to the fine particles in the capsule was confirmed. As shown in FIG. 16, at the time of white display, a non-uniform particle size and a non-uniform white display were obtained. In addition, as shown in FIG. 17, when the blue color is displayed, a white shade can be confirmed in the particle outline, and it can be seen that the capsule is a fine particle-containing capsule in which the fine particles inside the capsule are hardly caught by the capsule film.

It is the schematic which shows the microchannel which produces the conventional microparticles. It is A-A 'sectional drawing in the microchannel which produces | generates the conventional microparticle of FIG. It is a conceptual diagram which shows the microchannel in a 1st Example. It is L-L 'sectional drawing of the flow path in FIG. FIG. 4 is a cross-sectional view taken along the line M-M ′ in FIG. 3. It is a conceptual diagram which shows the microchannel structure in a 1st Example. It is a figure explaining the manufacturing method of the micro droplet, gel, and capsule in a 1st Example. It is a photograph of the micro droplet collected in the 1st example. It is the microcapsule produced | generated in the 1st Example. It is a photograph of the micro droplet collected in the 1st comparative example. It is the microcapsule produced | generated in the 1st comparative example. It is a photograph of the micro droplet collected in the 2nd example. It is the microcapsule produced | generated in the 2nd Example. It is the photograph of the microcapsule displayed in white in the 2nd Example. It is the photograph of the microcapsule displayed in blue in 2nd Example. It is the photograph which displayed the microcapsule produced without using a microchannel in white. It is the photograph which displayed the microcapsule produced without using a microchannel in blue.

Explanation of symbols

1: Substrate 2: Continuous phase introduction port 3: Continuous phase introduction channel 4: Dispersed phase introduction port 5: Dispersed phase introduction channel 6: Intersection 7: Discharge channel 8: Discharge port 9: Inlet port 10: Cover body 11: Holder 12: Microchannel structure 13: Heating container 14: Teflon (registered trademark) tube 15: Teflon (registered trademark) tube for curing 16: Teflon (registered trademark) tube for curing 17: Fillet joint 18: Micro syringe pump 19, 20: Micro syringe

Claims (12)

Introduction port and introduction flow path for introducing a dispersed phase, introduction port and introduction flow path for introducing a continuous phase, and discharge flow path for discharging particles generated through the dispersed phase and the continuous phase In addition, a method for producing solid particles using a micro-channel structure having a discharge port and a liquid in which a part of the fluid is previously made into an oligomer and / or polymer is sent to generate droplets. And producing a solid particle by forming a film on the surface of the droplet and then curing the film with an unreacted component. The method for producing solid particles according to claim 1, wherein a surfactant is contained in a fluid in which a part of the continuous phase or dispersed phase is previously oligomerized or polymerized. 2. The method for producing solid particles according to claim 1, wherein the continuous phase contains an oligomer or polymer as a raw material for the coating that covers the surface of the droplets in advance. 2. The method for producing solid particles according to claim 1, wherein the dispersed phase does not substantially contain an oligomer or polymer as a raw material for the coating that covers the surface of the droplets in advance. Capsules are produced as solid particles, and the method for producing solid particles according to any one of claims 1 to 4. The method for producing solid particles according to claim 5, wherein fine particles are contained in the dispersed phase to be fed in advance. 7. The method for producing solid particles according to claim 6, wherein the capsule containing the fine particles is for display using magnetophoresis or electrophoresis microcapsules. 8. The method for producing solid particles according to claim 5, wherein the liquid in the capsule is colored. Introducing a dispersed phase that does not contain monomer, oligomer, or polymer of the capsule film raw material into a continuous phase in which a part of the raw material of the capsule film is previously made into an oligomer or polymer, prepares a droplet and produces a capsule film, Thereafter, the film is cured with unreacted monomers or a crosslinking agent in the continuous phase while being fed in a thin tube, and the method for producing solid particles is characterized. The method for producing solid particles according to claim 9, wherein fine particles are contained in the dispersed phase to be fed in advance. The method for producing solid particles according to claim 9 or 10, wherein the capsule containing fine particles is for display using a magnetophoresis or electrophoresis microcapsule. A capsule for display obtained by the method for producing solid particles according to any one of claims 1 to 11, wherein the dispersity is 3% or less.

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