JP2006069591A - Blister package and its manufacturing method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a variety of blister packages for giving a user increased options for a choice of an insect-repellent collar through the use of characteristic of the blister package, and a method for capable of easily manufacturing the blister package. <P>SOLUTION: The blister package includes the insect-repellent collar 2 molded of a first resin 10 and a second resin 11 containing an evaporative plasticizer, a blister member 4 having permeable barrier properties and light permeability and including a storage 4a for receiving the collar 2, and a seal member 3 comprising a barrier layer having the permeable barrier properties and an adhesive layer overlying a paper base in this sequence. The blister member 4 and the seal member 3 are stuck to each other with the insect-repellent collar 2 stored in the storage 4a. Decoration comprising two or more kinds of colors is applied to at least part of the collar 2. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a blister package in which an anthelmintic collar is housed in a blister package and a method for producing the blister package. More specifically, a blister package that is attached to the neck of an animal such as a dog or cat and has a deworming collar that has an anti-parasitic effect for controlling pests such as fleas and ticks in a blister package and a method for producing the blister package It is about.

  2. Description of the Related Art Conventionally, there are various kinds of anthelmintic collars for pets such as dogs and cats, and packaging containers that package the anthelmintic collars. As such a packaging container, a blister packaging container is known in which an antiparasitic collar that is an object to be packaged can be easily confirmed from the outside.

  Patent Document 1 filed by the inventor of the present application has a gas barrier property in which a mount on which a thermoplastic resin layer is formed and a blister member for storing an object to be packaged are bonded. A blister packaging container is disclosed. A collar impregnated with a pesticidal insecticide for exterminating fleas of pets such as dogs and cats is exemplified as an item to be packaged in this blister packaging container.

Patent Document 2 discloses a blister packaging container having gas barrier properties. Patent Document 3 describes a blister packaging container having gas barrier properties as in Patent Document 2, and a flea removing collar is described as an object to be packaged in this blister packaging container.
JP 2000-118559 A (published on April 25, 2000) Japanese Utility Model Publication No. 62-7568 (announced February 21, 1987) JP 2000-31474 A (published on November 14, 2000)

  However, the above Patent Document 2 does not disclose any flea removal collar. In addition, in Patent Document 3, the configuration of the flea removing collar housed in the blister packaging container describes that triethyl phosphate is contained in the collar resin as a transpiration plasticizer. There is no description of the colors, patterns, etc.

  Furthermore, the collar accommodated in the blister packaging container described in Patent Document 1 is a single color that is not decorated at all. Therefore, despite the use of a blister packaging container that can easily confirm the package from the outside, the package has a low decorative property.

  Therefore, the types of collars housed in the blister packaging containers described in Patent Documents 1 and 3 are limited, and the user of the anthelmintic collar has the limited types of collars at the time of purchase. In other words, the only option was to purchase a solid collar. Furthermore, in recent years, the number of households that keep pets has increased, and the types of pets have also diversified, so a wide variety of anthelmintic collars are desired.

  The present invention has been made in view of the above problems, and its purpose is to make use of the characteristics of blister packaging containers, and to provide a variety of blister packagings that expand the user's selection range and the blister packagings. An object of the present invention is to provide a method that can be easily manufactured.

  In order to solve the above-mentioned problems, the blister package according to the present invention has an anthelmintic collar formed using a resin containing a transpirationable plasticizer, a transmission barrier property and a light transmission property, A blister member having a storage portion for storing a collar for use, and a sealing member in which a barrier layer having a transparent barrier property and an adhesive layer are laminated in this order on a paper substrate, and the antiparasitic collar in the storage portion Is a blister package in which the blister member and the seal member are adhered to each other, and at least a part of the anthelmintic collar is decorated with two or more colors. It is characterized by that.

  Here, the said blister package means the blister package container in the state in which the collar for anthelmintic insects was stored. Moreover, since the said decoration means that two or more types of colors are given, the thing to which the color scheme of only red and only blue is given, for example is not included in this invention. On the other hand, for example, it is assumed that decoration using two colors of red and blue is decorated regardless of the color scheme. Further, the permeation barrier property indicates a property of suppressing permeation of gas and / or liquid material, for example. Furthermore, the sealing member may have a transmission barrier property.

  As described above, conventionally, the user of the anthelmintic collar contained in the blister packaging container has to select a single color of the anthelmintic collar at the time of purchase.

  On the other hand, according to the above configuration, in the blister package, since the blister member has light transmittance, the anthelmintic collar can be confirmed from the outside, and at least one of the anthelmintic collars. The decoration is given to the part. Accordingly, it is possible to provide a blister package in which a highly decorative caterpillar collar is housed in a blister package. Thereby, the selection range at the time of purchase can be expanded with respect to the user of the anthelmintic collar. That is, since it is possible to provide a blister package rich in variations, it is possible to satisfy the user's preference.

  Further, a blister member having a transmission barrier property, and a sealing member having an adhesive layer and a barrier layer for the blister member are bonded to each other, and a resin containing a transpirationable plasticizer is contained in the blister member storage portion. It contains an anthelmintic collar molded using it. For this reason, at the time of storage, the transpiration of the medicine contained in the anthelmintic collar can be suppressed and the airtightness can be maintained. On the other hand, when opened, the transpiration of the drug contained in the anthelmintic collar can be increased.

  In the blister package according to the present invention, the blister member preferably has a film layer made of a material having an easy peel property with respect to the adhesive layer.

  According to the above configuration, since the blister member has a film layer made of a material having an easy peel property with respect to the adhesive layer, the blister member film layer adhered to each other and the adhesive layer of the seal member are combined. It can be removed easily and cleanly. Therefore, the anthelmintic collar can be easily taken out from the blister packaging container.

  In the blister package according to the present invention, the resin is preferably at least one resin selected from the group consisting of a thermoplastic resin, a thermosetting resin, a synthetic rubber, or a thermoplastic elastomer. According to the said structure, since the said resin is a thermoplastic resin, a thermosetting resin, a synthetic rubber, or a thermoplastic elastomer, a chemical | medical agent can be easily contained in the said resin.

  In the blister package according to the present invention, it is preferable that the anthelmintic collar has a plurality of regions having different colors.

  Here, the different regions refer to portions having different colors. Accordingly, even if the portions are separated from each other, if the colors are the same, the regions are the same.

  According to the above configuration, the anthelmintic collar has a plurality of regions having different colors, and therefore different colors are used in adjacent regions. Therefore, by combining the regions, a multicolor anthelmintic collar can be provided, and the options of the user can be expanded compared to a blister package that contains a monochromatic anthelmintic collar.

  In the blister package according to the present invention, the region is preferably made of different materials for each color.

  According to the above configuration, for example, a resin having a different material is used for a region containing a drug and a region not containing a drug, or a plurality of resins having different materials containing different types of drugs are stacked. Therefore, it is possible to provide a blister package that can be used for a wider range of applications than before.

  In order to solve the above problems, a blister package manufacturing method according to the present invention comprises a blister member having a transmission barrier property and a light transmission property, and having a storage portion in which an anthelmintic collar is stored, and a paper substrate. A blister package manufacturing method in which a barrier layer having a transparent barrier property and a sealing member provided with an adhesive layer are bonded to each other, wherein a resin containing a transpirationable plasticizer is used in the storage portion. The blister member and the seal member are bonded to each other in a state in which an anthelmintic collar that is molded and at least partially decorated is housed.

  According to the above configuration, since the blister member is light transmissive, it is possible to confirm the anthelmintic collar from the outside, and at least a part of the anthelmintic collar is decorated. Therefore, the user's selection range of the anthelmintic collar can be expanded. That is, it is possible to manufacture a blister package that is rich in variations, and satisfy the user's preference.

  Further, a blister member having a transmission barrier property and a sealing member having an adhesive layer and a barrier layer for the blister member are bonded to each other, and a resin containing a transpiration agent is contained in the storage portion of the blister member. It contains an anthelmintic collar molded using it. Accordingly, it is possible to manufacture a blister package that suppresses the transpiration of the drug and maintains its airtightness during storage. On the other hand, it is possible to manufacture a blister package that enhances transpiration of the drug contained in the anthelmintic collar when opened.

  In the method for producing a blister package according to the present invention, the decoration is preferably performed using an ink jet image forming apparatus. According to the above configuration, since the decoration is formed using the ink jet type image forming apparatus, the ink is directly dropped on the surface of the molded resin, and the solvent in the ink dissolves the resin to give the decoration. . As a result, it is possible to prevent the ink from oozing out with the sustained release of the medicine and the ink from peeling off, and it is possible to easily obtain a blister package that maintains high decorativeness. Therefore, it is possible to provide a user with a blister package that is richer in variation than in the past.

  In the method for producing a blister package according to the present invention, it is preferable to apply the decoration using an ink containing an ultraviolet curable resin, and then irradiate the decorated part with ultraviolet rays. Since the decoration is performed using an ink containing an ultraviolet curable resin and the ultraviolet rays are irradiated after the decoration is applied, the ultraviolet curable resin in the ink used for the decoration can be cured. As a result, since the ink can be cured, the light resistance, impact resistance, and wear resistance of the decoration can be improved.

  In the method for producing a blister package according to the present invention, it is preferable to heat the molded resin before applying the decoration. Since it heats before giving the said decoration, resin shape | molded previously can be heated to desired temperature. As a result, it is possible to more easily apply the decoration to the molded resin surface, and it is possible to further prevent the ink from bleeding and peeling.

  In the method for producing a blister package according to the present invention, the decoration may be applied by using an extrusion molding machine that supplies a plurality of resins individually and merges and molds the plurality of resins.

  According to the above configuration, the plurality of resins are individually supplied and merged while extruding the plurality of resins. Thereby, a multicolor multilayer and a multi-material anti-insect collar can be manufactured by extruding a desired resin. Therefore, a blister package containing the anthelmintic collar can be easily manufactured.

  In the method for producing a blister package according to the present invention, the decoration may be applied using an injection molding machine that individually injects and molds a plurality of resins.

  According to the said structure, several resin is inject | poured independently, respectively. Thereby, by injecting a desired resin, it is possible to easily produce a multicolor multilayer and a multi-material anthelmintic collar. Therefore, a blister package containing the anthelmintic collar can be easily manufactured.

  In the method for producing a blister package according to the present invention, the decoration may be applied by transfer. According to the said structure, the blister package which accommodated the antiparasitic collar which improved the decorativeness can be manufactured easily.

  The blister package according to the present invention, as described above, has an anthelmintic collar molded using a resin containing a transpirationable plasticizer, and has a transmission barrier property and a light transmission property. A blister member having a storage portion to be stored; and a seal member in which a barrier layer having a transmission barrier property and an adhesive layer are laminated in this order on a paper base material, and the collar for deworming is stored in the storage portion. In this state, the blister package is formed by adhering the blister member and the seal member to each other, and at least part of the anthelmintic collar is decorated with two or more colors.

  In addition, as described above, the method for producing a blister package according to the present invention has a transmission barrier property and a light transmission property, and a blister member having a storage portion in which an anthelmintic collar is stored, and a paper substrate. A method for producing a blister package in which a barrier layer having a transparent barrier property and a sealing member provided with an adhesive layer are bonded to each other, wherein the housing portion is molded using a resin containing a transpirationable plasticizer. In addition, the blister member and the seal member are bonded to each other in a state in which the anthelmintic collar on which at least a part is decorated with two or more colors is housed.

  Thereby, at least a part of the anthelmintic collar that is housed in the blister packaging container and can be easily confirmed from the outside is decorated. Therefore, there is an effect that it is possible to provide the user with a blister package having a wide selection range and a manufacturing method thereof.

  An embodiment of the present invention will be described with reference to FIGS. 1 to 11 as follows.

  As shown in FIG. 1, the blister package according to the present embodiment is configured such that an anthelmintic collar 2 is housed in a blister packaging container 1. The blister packaging container 1 has a mount 3 as a sealing member and a blister member 4. Specifically, a mount as a sealing member having a transparent barrier property (hereinafter simply referred to as “barrier property”) and a light transmitting property (having a haze of 20 or less) and a thermoplastic resin layer formed on the surface thereof. 3 and a blister member 4 made of a thermoplastic resin having barrier properties and light transmission properties, for housing the anthelmintic collar 2 as a package body. That is, according to the blister packaging container 1, the anthelmintic collar 2 is packaged so as to be visible from the outside.

  The barrier property of the mount 3 and the blister member 4 indicates the property of suppressing the permeation of gas and / or liquid, and is particularly suitably used for the purpose of suppressing the permeation of gas.

  The blister member 4 has an accommodating portion (accommodating portion) 4a formed along the shape of the anthelmintic collar 2 for accommodating the anthelmintic collar 2, and an outer peripheral edge (near the outer portion) of the accommodating portion 4a. It is comprised with the planar collar part 4b formed along. The collar portion 4 b serves as an adhesive portion for the mount 3, and a part thereof is not adhered to the mount 3, and serves as a grip portion 4 c for peeling the adhered blister member 4 from the mount 3.

  Therefore, in the blister packaging container 1 configured as described above, as shown in FIG. 2, the handle 4c is lifted away from the mount 3 to peel off the collar 4b from the mount 3, and the stored anthelmintic collar 2 is taken out. It is like that.

  Here, the adhesion mechanism between the mount 3 and the brim 4b of the blister member 4 will be described below with reference to FIG. In addition, although the layer thickness of each layer in the mount 3 and the blister member 4 is actually different, in FIG. 3, the layer thickness of each layer is made substantially the same for convenience of explanation.

  As shown in FIG. 3, the mount 3 has a three-layer structure in which a paper base 5, a gas barrier layer (barrier layer) 6, and a polyolefin layer (adhesive layer) 7 are laminated in this order. These film thicknesses are about 500 μm for the paper substrate 5, about 25 μm for the gas barrier layer 6, and about 30 μm for the polyolefin layer 7.

  The paper base 5 is made of, for example, coated cardboard, cart paper, or Manila cardboard. The gas barrier layer 6 is made of aluminum, polyethylene terephthalate (PET), or the like, and is mainly a layer for imparting gas barrier properties to the mount 3. The polyolefin layer 7 is made of, for example, L-LDPE, and is a layer for mainly imparting adhesiveness to the blister member 4 to the mount 3.

  Between the paper substrate 5 and the gas barrier layer 6 and between the gas barrier layer 6 and the polyolefin layer 7, an air system such as vinyl acetate resin, ethylene-vinyl acetate copolymer resin, or acrylic resin is used. A base sheet 3 having a three-layer structure is configured by adhering them with an adhesive interposed therebetween.

  Further, as shown in FIG. 3, the blister member 4 is made of a thermoplastic resin having gas barrier properties and light transmittance, and is bonded to the polyolefin layer 7 corresponding to the uppermost layer of the mount 3. The laminated film (film layer) 8 and the PET layer 9 are laminated through the air-based adhesive. The layer thickness of each of these layers is about 25 μm for the laminated film 8 and about 350 μm for the PET layer 9. The gas barrier layer 6, the polyolefin layer 7, the laminated film 8, and the PET layer 9 are formed using a thermoplastic resin.

  The laminated film 8 is a layer mainly for imparting easy peelability to the polyolefin layer 7, that is, ease of peeling. As a material having such an easy peel property for the polyolefin layer 7, for example, TAF610C manufactured by Tosero Co., Ltd. is preferably used. The PET layer 9 is a layer that mainly imparts gas barrier properties to the blister member 4. As the PET layer 9, for example, PT-700 manufactured by Polytec Corporation is preferably used.

  The gas barrier layer 6 and the PET layer 9 imparting gas barrier properties are not limited to those mentioned above, but may be low density polyethylene (LDPE), high density polyethylene (HDPE), unstretched polypropylene (CPP), Polypropylene (OPP), crystalline polyethylene terephthalate (C-PET), stretched nylon (ON), polyvinyl alcohol (PVA), ethylene vinyl alcohol copolymer laminate (EVOH), and high-barrier film coated with polyvinylidene chloride Examples thereof include polypropylene (KOP), polyvinylidene chloride-coated polyester (KPET), polyvinylidene chloride-coated stretched nylon (KON), and polyvinylidene chloride-coated cellophane (K cello). In particular, a PET resin is preferably used.

  From the above, when the brim part 4b of the blister member 4 is heated, the laminated film 8 and the polyolefin layer 7 are thermally bonded, and as shown in FIG. 1, the mount 3 and the blister member 4 are bonded. The blister packaging container 1 is obtained.

  Therefore, in the blister packaging container 1 having the above-described configuration, the blister member 4 having a barrier property and the mount 3 are used, and the blister member 4 and the mount 3 are further separated by the antiparasitic collar 2 which is a packaged body of the blister member 4. Since it is continuously heat-bonded at the flange portion 4b in the vicinity of the outer portion of the housing portion 4a, which is the housing portion, the airtightness of the blister packaging container 1 is enhanced.

  If the airtightness is high in this way, when the thing containing the transpiration substance is packaged as the anthelmintic collar 2, the transpiration substance does not evaporate in the blister packaging container 1 having the above structure, so that the blister packaging container 1 The quality of the anthelmintic collar 2 is not deteriorated until it is opened.

  Further, in the mount 3 having the above-described configuration, in order to improve airtightness, a gas barrier which is a thermoplastic resin layer having a barrier property as an adhesive layer to the blister member 4 on the paper base material 5 and having light transmittance. Since the layer 6 and the polyolefin layer 7 are provided, the cost is lower than that using an aluminum foil or an aluminum deposited film. Therefore, the blister packaging container 1 itself can be made inexpensive, and accordingly, the blister packaging can be made inexpensive.

  Moreover, since the mount 3 uses the paper base 5 made of paper as the base, unlike the aluminum foil or the like, it is possible to easily print the name and description of the package.

  In the present invention, a so-called impulse sealing method is used for bonding the brim 4b of the blister member 4 to the mount 3 by instantaneously heat-sealing the resin at the bonded portion.

  Next, the anthelmintic collar 2 housed in the blister packaging container 1 will be described. FIG. 4 is a plan view of the anthelmintic collar 2. This anthelmintic collar 2 has a resin containing a drug for controlling pests such as fleas and ticks.

  Examples of the resin used in the anthelmintic collar 2 of the present invention include thermoplastic resins, thermosetting resins, synthetic rubbers, thermoplastic elastomers, and the like.

  Examples of the thermoplastic resin include a polyolefin resin, polyvinyl chloride, polyvinyl alcohol, polycarbonate, polyester, polystyrene, polymethyl methacrylate, and the like. Among these, it is preferable to use a polyolefin resin.

  Specific examples of the polyolefin resin include high-density polyethylene, low-density polyethylene, linear low-density polyethylene, ultra-low-density polyethylene, and a polyethylene resin such as a copolymer of ethylene and an α-olefin having 3 or more carbon atoms. , Propylene homopolymer, random copolymer or block copolymer of propylene and α-olefin having 4 or more carbon atoms, ethylene-methyl methacrylate copolymer, ethylene-vinyl acetate copolymer, ethylene-acrylic acid copolymer Copolymers, copolymers of carboxylic acid derivatives having an ethylenically unsaturated bond such as ethylene-vinyl acetate-methyl methacrylate copolymer and ethylene, resins such as polyvinyl alcohol and polyvinyl acetate, polybutadiene, polyisoprene, styrene-butadiene Copolymers and other rubber and cyclic olefin heavy Coalesced and its hydrogenated petroleum resin, rosin resin, coumarone-indene resin, terpene resin and the like.

  Examples of the thermosetting resin include polyurethane and epoxy resin. Examples of the synthetic rubber include SBR and EPDM.

  Examples of the thermoplastic elastomer include olefin-based thermoplastic elastomers and styrene-based thermoplastic elastomers. Specifically, an elastomer having ethylene or propylene as a main component can be cited as an olefin thermoplastic elastomer, and an elastomer having styrene or butadiene as a main component can be cited as a styrene thermoplastic elastomer.

  The thermoplastic elastomer has a crosslinked structure different from that of synthetic rubber, and has, for example, a structure in which each component is partially crosslinked. For this reason, fluidity | liquidity is shown by heating. That is, since it exhibits a behavior as a thermoplastic resin by heating, it is easy to handle and can be recycled.

  Each compound exemplified as these thermoplastic resins, thermosetting resins, synthetic rubbers, and thermoplastic elastomers may be used alone or in combination of two or more, and the type of chemical used Can be selected.

  Specifically, among these resins, a resin having a high molecular chain mobility and a low glass transition temperature is more preferable from the viewpoint of increasing the sustained release (bleed) rate of the drug. Moreover, what does not raise | generate a chemical reaction etc. between a chemical | medical agent is preferable. In particular, thermoplastic resins are excellent in formability and economy, and furthermore, the solubility and diffusibility of drugs can be controlled over a wide range by appropriately selecting the type of thermoplastic resin and the type of additive added. It is more preferable as a material for controlling drug bleeding. In addition, when molding the anthelmintic collar 2 of the present invention, a resin that can be molded at a low temperature from the viewpoint of controlling the disappearance of the drug by decomposition of the drug, transpiration to the environment, elution to cooling water, etc. Is preferably selected from the above thermoplastic resins.

  In addition, the drug used in the present invention is not particularly limited as long as it has an effect of controlling fleas and mites parasitic on animals such as dogs and cats. Specifically, pyrethroid compounds, organophosphorus compounds, carbamate compounds, neonicotinoid compounds, insect growth control compounds, and the like can be used.

  Examples of pyrethroid compounds include permethrin, allethrin, prareslin, cyphenothrin, phenothrin, resmethrin, empentrin, fenvalerate, fenpropathrin, cyhalothrin, cyfluthrin, etofenprox, tralomethrin, esbioslin, transfluthrin, teraleslin, etc. Can do.

  Examples of the organic phosphorus compound include fenitrothion, nared, fenthion, cyanophos, chlorpyrifos, diazinon, calclofos, salicione, and the like. Examples of the carbamate compound include methoxadiazone, propoxur, carbaryl, and fenocarb.

  Examples of neonicotinoid compounds include imidacloprid, acetamiprid, nitenpyram, and the like. Examples of the insect growth control compound include pyriproxyfen, mesoprene, hydroprene, diflubenzuron, cyromazine, phenoxy curve, and renenuron.

  In addition, although the said chemical | medical agent has a compound containing an optically active substance, these can also be used as a chemical | medical agent of this invention. Moreover, the said chemical | medical agent may be used individually, respectively, and 2 or more types can also be mixed and used for it. Furthermore, in addition to the drug, a potency enhancer that enhances the anthelmintic effect of the drug may be used in combination. As the potency enhancer, for example, piperonyl butoxide, sinepiline-222, octachlorodipropyl ether, MGK-264 and the like can be used.

  In addition, an acaricidal agent such as a trifluoromethanesulfonic acid anilide compound may be used as an acaricidal agent. In addition, repellents such as N, N-diethyl-m-triamide and caran-3,4-diol can also be used as drugs having an effect of repelling insects and the like. Furthermore, as antibacterial / antifungal and antifouling agents, isothiazoline compounds such as N-phenylbenzisothiazolone-3, 4,6-dimethyl-2- (6-phenylpyridin-2-yl) pyrimidine and the like Antibacterial / antifungal and antifouling agents such as pyridylpyrimidine compounds, oxonic acid, and vinylazine can also be used, and other commercially available herbicides, plant growth regulators, rust inhibitors, lubricants, antiblocking agents Further, a surfactant, an antistatic agent and the like can be used.

  In the present invention, the method of blending the above-mentioned drug into the resin is not particularly limited, and after the raw materials are kneaded using a mixer such as a Banbury mixer, a super mixer or an extruder, the resin composition in the form of powder or pellets It can be a thing. The method for pulverizing the resin is not particularly limited, and examples thereof include a freeze pulverization method. In addition, a molded body containing no drug is molded in advance by a method described later, and the molded body obtained is immersed in a liquid made of the drug, or the liquid is applied to the molded body to impregnate the molded body with the drug. You may mix | blend by the method of making it absorb.

  In the resin composition of the present invention, when the amount of the drug is less than 1.1 times the saturated dissolution amount of the drug in the resin, the amount of bleed when the resin composition is formed into a molded body is small and sufficient. The effect is not obtained. Therefore, the compounding amount of the drug is 1.1 times or more of the saturated dissolution amount of the drug in the resin, preferably 1.2 times or more, more preferably 1.5 times or more. There is no particular upper limit for the drug contained in the resin composition, but even if the amount is more than necessary, the drug tends to bleed during storage of the molded product. The amount of dissolution is 10 times or less.

  Here, the saturated dissolution amount of the drug in the resin is determined by the following method. A resin sheet having an appropriate size, for example, a length of 5 cm, a width of 5 cm, and a thickness of 500 μm is measured, and then immersed in a drug solution at 23 ° C. The resin sheet is taken out from the drug solution every few hours from the start of immersion and the drug solution adhering to the surface is wiped off. Then, the weight of the resin sheet is measured, and the saturated solubility of the drug in this resin is determined by the following procedure.

The resin sheet weight before immersion and W _0. The _first resin sheet weight measurement is performed t ₁ hour after the start of immersion (however, 0 <t ₁ ≦ 12), and the resin sheet weight at this time is W ₁ and the solubility is D ₁ [D ₁ = 100 × _{(W 1 -W 0) / W} 0]. A second resin sheet weight measurement is performed t ₂ hours after the start of immersion (however, 12 <t ₂ ).
N th after t _n time from start of immersion (where, n is an integer of 2 or more) when the resin sheet weight in the resin sheet weighing W _n, the solubility and D _n, D _n is calculated by the following equation.
D _n (%) = 100 × (W _n −W ₀ ) / W ₀
When the solubility change amount per unit time until when the elapsed immersed after the start t _n time from the time of lapse immersed after the start t _n-1 hour and E _n, E _n is expressed by the following equation.
E _n = (D _n −D _n−1 ) / (t _n −t _n−1 )
E _n is the solubility D _n at time point when it satisfies the following equation is defined as the saturation solubility.
100 × E _n / E ₁ ≦ 1
In the above formula, E ₁ is defined by the formula: E ₁ = D ₁ / t ₁ .

  When two or more types of drugs are mixed and used, if the mixture of the drugs is liquid at 23 ° C., a resin sheet is immersed in the drug mixture solution, and the drug mixture solution is added to the resin in the same manner as described above. Determine saturation solubility.

  When the drug to be used is solid at 23 ° C., the saturated solubility at 23 ° C. is determined by the following method. For example, 5 parts by weight of a drug is added to 100 parts by weight of the resin, melt-kneaded, and then pressed to form a sheet. After leaving the sheet at 23 ° C. for one day, the sheet surface is wiped off, and the sheet weight before and after wiping is compared. When the sheet weight is reduced by wiping, the saturated solubility of the drug in this resin is determined to be less than 5% by weight.

  Next, the same operation is performed with the drug addition amount being less than 5 parts by weight, for example, 4 parts by weight. When the sheet weight does not decrease by wiping the sheet surface, the saturated solubility of the drug in this resin is 4% by weight or more and less than 5% by weight. Further, when it is necessary to obtain a strict saturation solubility, the same operation is performed by adding 4 parts by weight or more, for example, 4.5 parts by weight of a drug. When the weight of the sheet is reduced by wiping with 4 parts by weight of the drug added, the amount of the drug added is further reduced and the same operation is performed.

  In this way, the operations of melt kneading, pressing and wiping the surface are repeated while adjusting the amount of the drug added. Saturation solubility can be determined from the maximum drug addition amount when the sheet weight does not decrease due to wiping and the minimum drug addition amount when the sheet weight decreases due to wiping.

  When a mixture of two or more drugs is used and the mixture of the drugs is a solid at 23 ° C., a sheet is prepared by melting and kneading the mixture of the drugs in a resin in the same manner as described above, The saturation solubility can be determined by wiping the sheet surface and examining the change in sheet weight before and after wiping.

  Various plasticizers may be added to the resin composition. As the plasticizer, for example, a plasticizer having a transpiration property, that is, a transpiration plasticizer can be used. By adding a transpirationable plasticizer to the resin composition, the saturated dissolution amount of the drug in the resin composition is increased, and bleeding from the molded product obtained from the resin composition is suppressed under sealing conditions. On the other hand, under the open conditions, with the transpiration of the transpirationable plasticizer, the amount of saturated dissolution of the drug in the molded body decreases, and as a result, the unique release behavior that the supersaturated drug bleeds from the molded body. realizable. The above sealing condition is a condition that achieves an environment that suppresses the transpiration of the transpirationable plasticizer from the molded body. For example, the sealing condition is achieved by sealing the molded body with a material having gas barrier properties. it can.

  The evaporative plasticizer used in the present invention is an organic compound having a vapor pressure at 20 ° C. of 0.13 Pa (0.001 mmHg) or more. From the viewpoint of further promoting the bleeding of the drug from the molded body, an organic compound having a value of 1.3 Pa (0.01 mmHg) or more is more preferable, and an organic compound having a value of 13 Pa (0.1 mmHg) or more is particularly preferable. preferable. The upper limit of the vapor pressure at 20 ° C. of the transpirationable plasticizer is not particularly limited, but from the viewpoint of molding processability, it is usually preferable that the boiling point is equal to or higher than the melt molding temperature of the resin composition. From the viewpoint of moldability, the upper limit value of the vapor pressure of the transpirationable plasticizer is usually 13000 Pa (100 mmHg) or less, more preferably 1300 Pa (10 mmHg) or less, and particularly preferably 130 Pa (1 mmHg) or less.

  Moreover, from the viewpoint of the effect of keeping the drug more stably in the resin composition, it is more preferable that the transpirationable plasticizer has good compatibility with the resin and the drug. Compatibility can also be expressed in terms such as solubility or miscibility and is an important factor in determining (saturated) solubility. The degree of compatibility or (saturated) solubility can be estimated from the solubility parameter and the dielectric constant. Experimentally, for example, the following methods are generally known. Solubility in polyvinyl chloride can be determined by repeating a bleed test with a test sheet consisting of a resin, a transpiration plasticizer, and a drug under conditions where the transpiration plasticizer does not evaporate (reference: polyvinyl chloride-its basis and Application-(Company) Kinki Chemical Society vinyl section edited by p356-357 (1988) Nikkan Kogyo Shimbun). Moreover, the solubility with respect to other resin, such as polyolefin resin, can be determined by the same method.

  The transpirationable plasticizer can be selected from esters (liquid alcohol, liquid ketone, fragrance, animal and plant essential oils, etc.) that are liquid at room temperature (23 ° C.) (hereinafter sometimes simply referred to as liquid). Examples of the liquid ester include phthalic acid esters, linear dibasic acid esters, and phosphoric acid esters. Specific examples of transpiration plasticizers suitable for the present invention include dimethyl adipate, dimethyl glutarate, dimethyl succinate, dimethyl phthalate, diethyl phthalate, triethyl phosphate, tributyl phosphate, dimethyl malate, dimethyl succinate. Etc. Also, the blending amount of the transpirationable plasticizer is 100 parts by weight of the resin from the viewpoint of more stably holding the drug in the resin composition and more stably holding the transpirationable plasticizer in the resin composition. On the other hand, it is 0.1-100 weight part, More preferably, it is 1-50 weight part, More preferably, it is 5-30 weight part.

Further, in the combination of the transpirationable plasticizer and the drug, the following formula P1 / P2 ≧ 2
It is preferable that P1 represents the vapor pressure at 20 ° C. of the transpiration plasticizer and P2 represents the vapor pressure of the drug at 20 ° C. In the case of P1 / P2 <2, since the difference between the vapor pressure of the evaporating plasticizer and the vapor pressure of the drug is small, the effect of the release behavior of the drug from the molded body under the open condition is reduced. From the viewpoint of increasing the effect of the release behavior of the present invention, the ratio of P1 and P2 is more preferably P1 / P2 ≧ 5, more preferably P1 / P2 ≧ 10, and particularly preferably P1 / P2 ≧ 1000. The larger value of P1 / P2 is more preferable, and the upper limit value is not particularly limited, but is usually 10 ¹⁰ or less.

  Moreover, the ratio of the blending amount of the transpiration plasticizer and the blending amount of the drug in the present invention is appropriately determined according to the required bleeding characteristics and the purpose of use. For example, in order to realize the adjustment of the timing at which drug bleeding starts, the blending amount may be determined as follows. That is, in order to start the bleeding of the drug immediately after the start of use, the transpiration relative to the amount of the drug is such that the concentration of the drug in the resin composition becomes supersaturated only by a slight evaporation of the evaporating plasticizer. The amount ratio of the plasticizer may be set low. Also, in order to start the bleeding of the drug after a certain period of time has elapsed since the start of use, the concentration of the drug in the resin composition should not be oversaturated unless a certain proportion of the evaporating plasticizer is evaporated. What is necessary is just to set the quantity ratio of a transpirationable plasticizer high. The saturated solubility of the drug in the resin can be determined by the same method as in the case of the transpiration plasticizer described above. Further, the amount of transpirationable plasticizer reduced by transpiration (transpiration amount) can be determined in advance by a method such as measuring the change over time of the remaining amount of transpirationable plasticizer in the molded body.

  In addition to the method of changing the ratio of the blending amount of the transpiration plasticizer and the blending amount of the drug, the timing of starting the bleeding of the drug can be adjusted by changing the vapor pressure of the transpiration plasticizer. it can. That is, a vaporizable plasticizer with a higher vapor pressure may be used in order to start the bleeding of the drug earlier, and conversely, a vaporizable plasticizer with a lower vapor pressure should be used to slow down the drug bleeding. That's fine. Moreover, the adjustment of the timing at which the bleeding of the drug starts can also be adjusted by the addition amount of the bleeding accelerator, which will be described later. Adjustment of the bleed speed can also be achieved by these methods. Applying the quasi-stationary assumption of Higuchi et al. (Reference: Higuchi et al., J. Pharm. Sci., Vol. 50, 874 (1961)) to the present invention, the bleed rate of the drug in the present invention is the surface area of the molded product, the diffusion of the drug. It is proportional to the square root of the coefficient and the supersaturation of the drug. From this knowledge, when controlling the bleed speed of the drug, for example, to increase the bleed speed, the supersaturation of the drug may be increased. Further, by using a transpiration plasticizer having a high transpiration rate, for example, a transpiration plasticizer having a high vapor pressure, the bleed speed at the initial stage of use can be increased.

  The blending method into the resin such as the transpiration plasticizer is not particularly limited, and after mixing the raw materials using a mixer such as a Banbury mixer, a super mixer, an extruder, etc. It can be set as a resin composition. In addition, a molded body that does not contain a transpirationable plasticizer is preliminarily molded by the method described later, and the obtained molded body is immersed in a liquid composed of a transpirationable plasticizer, or transpiration is applied to the molded body. You may mix | blend by a method of making a molded object impregnate and absorb a property plasticizer.

  If necessary, the resin composition of the present invention further includes a bleed accelerator, a plasticizer other than the above-described transpiration plasticizer (hereinafter sometimes simply referred to as a plasticizer), a stabilizer, a filler, and a colorant. An antioxidant or the like can be appropriately blended. Among these, a bleed accelerator and a plasticizer can be suitably used for the purpose of obtaining the activity more effectively, such as improving the bleeding property of the drug or improving the spreading effect of the bleed drug. The bleed accelerator can be used to improve the bleedability of the drug, but can be suitably used to increase the diffusibility, particularly when the diffusibility of the drug in the resin composition is low.

  As such a bleed accelerator, the higher the diffusibility in the resin composition, the lower the solubility in the resin composition, and the higher the solubility in the transpiration plasticizer, the better. In particular, carboxylic acid is preferable as a bleed accelerator, and specific examples thereof include fatty acids such as lauric acid, myristic acid, palmitic acid and stearic acid, aromatic carboxylic acids such as benzoic acid, tartaric acid, fumaric acid and malic acid. And dicarboxylic acids such as citric acid. Examples of the bleed accelerator include silicone compounds such as polydimethylsiloxane and polymethylphenylsiloxane, and fluorine surfactants. As described above, the blending amount of the bleed accelerator can be appropriately set depending on the timing at which the bleed of the active compound starts, but is usually 0.1 to 100 parts by weight, and 1 to 50 parts by weight with respect to 100 parts by weight of the resin. Part is more preferable, and 5 to 20 parts by weight is more preferable.

  Moreover, in the resin composition of this invention, when using resin, such as polyvinyl chloride, polyester, polyvinyl alcohol, in order to provide a softness | flexibility, workability, etc., the plasticizer normally used can be mix | blended. Further, when using a resin having a high drug solubility, such as polyvinyl chloride, it is preferable to use a plasticizer having a vapor pressure of less than 0.013 Pa (0.0001 mmHg) and low compatibility with the resin. preferable. By using a plasticizer having low compatibility with such a resin, an effect of lowering the saturation solubility of the drug in the resin composition and further improving the bleeding property of the drug can be expected. Examples of such plasticizers include diisononyl adipate, diisodecyl adipate, di-2-ethylhexyl azelate, 2-ethylhexyl sebacate, epoxidized soybean oil, which are known as plasticizers having low compatibility with polyvinyl chloride resin. Examples include aliphatic polyesters. The amount of these plasticizers is usually 0.1 to 200 parts by weight, preferably 5 to 100 parts by weight, and more preferably 20 to 60 parts by weight with respect to 100 parts by weight of the resin.

  The resin composition of the present invention may contain an aliphatic hydrocarbon. Examples of the aliphatic hydrocarbon include a linear aliphatic hydrocarbon, a branched aliphatic hydrocarbon, and an aliphatic hydrocarbon having an unsaturated bond. In addition, examples of the substituent in the aliphatic hydrocarbon having a substituent used in the present invention include halogens such as chloro and bromo. Typical examples of such halogenated hydrocarbons include 1-chlorooctane, 2-chlorooctane, 1-bromooctane, 1-bromodecane, 1-bromododecane and the like. The aliphatic hydrocarbon used in the present invention is preferably an aliphatic saturated hydrocarbon having 7 to 17 carbon atoms, more preferably an aliphatic saturated hydrocarbon having 8 to 12 carbon atoms. More preferably, it is a linear aliphatic saturated hydrocarbon. Specifically, n-heptane, n-octane, n-decane, n-dodecane and the like. Aliphatic hydrocarbons may be used alone or in admixture of two or more.

  The content of the aliphatic hydrocarbon is preferably 20% by weight or more of the amount of drug contained in the resin composition. When the content of the aliphatic hydrocarbon is less than 20% by weight of the amount of the drug, it becomes difficult to suppress the bleeding of the drug during storage of the resin composition or the molded body made of the resin composition. In addition, there is no particular upper limit on the amount of aliphatic hydrocarbons contained in the resin composition, and the bleed start time of the drug can be controlled by the blending amount. However, when there are many liquid components in the resin composition, it becomes difficult to mold. Therefore, the total content of the drug and the liquid component of the aliphatic hydrocarbon is usually 60% by weight or less in the resin composition. Is preferred.

  The method for forming the resin composition into a flat plate shape is not particularly limited. For example, known molding methods such as injection molding, extrusion molding, press molding, and slush (powder) molding can be used. In addition, multilayer extrusion molding, multicolor injection molding, composite spinning, extrusion lamination molding, as appropriate, depending on the purpose such as improvement of mechanical properties at the time of use, high concentration of the molded product surface of the drug, or improvement of processing moldability. It can also be processed by various conventionally known methods.

  In addition, a molded body molded using the resin composition of the present invention is contained in the molded body during a storage period in a sealed state in which the volatile plasticizer and aliphatic hydrocarbon contained in the molded body are not evaporated. The supersaturated amount of the drug does not bleed on the surface, so that it can be stored for a long time. In addition, when the packaging is released, the transpirationable plasticizer and the aliphatic hydrocarbon are transpiration, and the bleeding of the medicine is started for the first time. That is, it is possible to control the bleed start time of the drug.

  The surface of the anthelmintic collar 2 of the blister package of the present invention is decorated with two colors and three layers, as shown in FIG. The anthelmintic collar 2 has two layers of pink first resin (region) 10 and one layer of white second resin (region) 11. However, the first resin 10 and the second resin 11 are simply indicated by hatching in color, and the first resin 10 and the second resin 11 may be made of the same material. Further, the colors shown here are merely examples, and the color arrangement is not limited to this.

  Here, a plurality of regions having different colors are formed in layers, but the present invention is not limited to this, and it is sufficient that at least one portion (region) having a different color is provided on the anthelmintic collar 2.

  Such decoration can be applied, for example, to a conventional monochromatic anthelmintic collar by an inkjet method using an image forming apparatus described later. Alternatively, an antiparasitic collar with a decoration may be manufactured by molding resins of the same material having different colors into a flat plate shape and press-bonding these resins. In the above description, the anthelmintic collar 2 has two layers of two colors. However, the present invention is not limited to this, and a multicolor multilayer may be used.

  In addition, for example, two or more types of resins of different materials may be used, that is, a plurality of resins may be formed by pressing a plurality of resins flattened by an extruder or the like into a multilayer structure. . In this case, the multicolor multilayer antiparasitic collar 2 can be manufactured by using resins of different colors. Moreover, you may manufacture the collar 2 for multi-colored insect repellents by what is called insert molding said 2 types of resin.

  Further, the multicolor multi-layered anthelmintic collar 2 as described above may be molded by the two-color injection molding method with the first resin 10 and the second resin 11 as shown below. The two-color molding may be performed not only by the same material but also by a different material (so-called double mold).

  Here, as an example, two-color molding using a core rotating method will be described. As shown in FIGS. 5A to 5D, the injection molding machine 34 according to the present embodiment includes a movable platen 35, a mold reversing unit 36, a mold unit 37, a fixed platen 38, and a primary injection unit. 39, and a secondary injection unit 40. The movable platen 35 is a base of the injection molding machine 34 and includes an ejector rod 47 inside. The mold reversing portion 36 is reversed by 180 ° by the rotation of the ejector rod 47. The mold reversing part 36 rotates 180 ° to rotate the mold part 37 integrally. The mold part 37 has a primary core 41 and a secondary core 42 having a protruding structure.

  The fixed platen 38 is arranged to face the mold part 37. The fixed platen 38 has two openings so that the primary injection unit 39 and the secondary injection unit 40 can be inserted. Further, the fixed platen 38 has a primary cavities 43 and a secondary cavities 44 which are two recessed portions on the surface facing the mold portion 37, and the primary cavities 43 and the secondary cavities 44 are provided. The primary core 41 and the secondary core 42 enter the cavity 44. Then, in the state where the primary core 41 and the secondary core 42 have entered the primary cavities 43 and the secondary cavities 44, gaps 45 formed in the primary cavities 43 and the secondary cavities 44. The laminator collar 2 can be formed by laminating a plurality of resins on 46.

  The primary injection unit 39 and the secondary injection unit 40 each contain a resin therein, and the accommodated resins are the primary injection unit 39 and the secondary injection unit. Injected from 40, the gaps 45 and 46 are stacked. Specifically, the primary injection unit 39 contains a resin colored in white. On the other hand, the secondary injection unit 40 contains a resin colored in pink. Here, these colors are merely examples, and the present invention is not limited to these. Moreover, the material of resin may be the same and may differ.

  Next, a method for manufacturing the decorated anthelmintic collar 2 using the injection molding machine 34 will be described.

  First, as shown in FIG. 5A, the resin is injected from the secondary injection unit 40 in a state where the fixed platen 38 is fitted to the mold part 37. By this injection, a layer of the first resin 10 is formed in the gap 46 (see FIG. 5B) between the secondary core 42 and the secondary cavities 46. After the injection, as shown in FIG. 5B, the mold part 37 is separated from the fixed platen 38 by a certain distance.

  Then, as shown in FIG. 5C, the mold part 37 is rotated by 180 ° via the mold reversing part 36 by the ejector rod 47 inside the movable platen 35. After the rotation, the fixed platen 38 is again fitted into the mold part 37, and the resin is injected from both the primary injection unit 39 and the secondary injection unit 40 as shown in FIG. By this injection, a layer of the first resin 10 is formed in the gap 45 between the primary core 41 and the primary cavities 43.

  On the other hand, a resin layer in which the first resin 10 and the second resin 11 are laminated is formed in the gap 46 between the secondary core 42 and the secondary cavities 44. Thereby, for example, if different resins are accommodated in the primary injection unit 39 and the secondary injection unit 40, a resin layer in which different resins are sequentially laminated by repeating 180 ° rotation and injection. Can be molded.

  Further, after the injection, in the same manner as described above, the mold part 37 is separated from the fixed platen by a certain distance. Then, in the same manner as described above, the die portion 37 is rotated by 180 ° via the die reversing portion 36 by the ejector rod 47 inside the movable platen 35. After the rotation, the fixed platen 38 is again fitted into the mold part 37 and the resin is injected from both the primary injection unit 39 and the secondary injection unit 40. By this injection, a resin layer in which the first resin 10 and the second resin 11 are laminated one by one can be formed in the gap 45 between the primary core 41 and the primary cavities 43.

  On the other hand, a resin layer in which two layers of the first resin 10 and one layer of the second resin 11 are laminated can be formed in the gap 46 between the secondary core 42 and the secondary cavities 44. In other words, the anthelmintic collar 2 shown in FIG. 4 is formed on the secondary core 42.

  Similarly, by repeating 180 ° rotation and resin injection, the gap 45 between the primary core 41 and the primary cavities 43 and the gap 46 between the secondary core 42 and the secondary cavities 44 are obtained. Alternately, the anthelmintic collar 2 shown in FIG. 4 can be formed.

  Next, a description will be given of a method of forming the multicolor multi-layered anthelmintic collar 2 by extrusion. As shown in FIG. 6, the extruder 48 according to the present embodiment includes a first extruder 49, a second extruder 50, a third extruder 51, and an extrusion die 52.

  The first extruder 49, the second extruder 50, and the third extruder 51 are all resin supply means for independently supplying a plurality of resins constituting the anthelmintic collar 2 of the blister package according to the present invention. It has become. The specific configuration of the first to third extruders 49, 50, 51 is not particularly limited, and a conventionally known general extruder can be used.

  In the case of forming the above-mentioned anthelmintic collar 2, as shown in FIG. 4, it is formed of one layer of the second resin 11 and two layers of the first resin 10 sandwiching the first resin. The extruder 49 and the third extruder 51 contain the same type of resin. Therefore, the first extruder 49 and the third extruder 51 may be replaced with one extruder. In order to manufacture the anthelmintic collar 2 shown in FIG. 4, the first resin 10 is accommodated in the first extruder 49 and the third extruder 51, and the second resin 11 is accommodated in the second extruder 50. That's fine.

  As shown in FIG. 6, the extrusion die 52 used in the extrusion molding machine 48 is particularly configured so that it can be discharged as one anthelmintic collar 2 by joining the three resin layers while extruding them. It is not limited.

  In this embodiment, as shown in FIG. 6, die channels 53, 54, and 55 connected to the first, second, and third extruders 49, 50, and 51, respectively, and the die channels 53, 54, and 55 It has a joining part 56 connected, a lip part 57 connected to the joining part 56, and a discharge port 58 connected to the lip part 57.

  The die channels 53, 54, and 55 supply the resin layers extruded from the first, second, and third extruders 49, 50, and 51 to the junction 56. The junction 56 joins the resin layers supplied through the die channels 53, 54, and 55 together. The lip portion 57 has a lip gap that is a gap having a predetermined shape, and allows a plurality of joined resin layers to pass through the lip gap. The discharge port 58 is formed at the end of the lip gap, and discharges the plurality of joined resin layers as one anthelmintic collar 2.

  The material constituting the extrusion die 52 is not particularly limited, and may have strength enough to withstand extrusion molding and workability enough to form the lip gap and the junction 56. That's fine. In the present embodiment, an example in which the flat plate-shaped anthelmintic collar 2 is manufactured is given. Therefore, the extrusion die 52 according to the present embodiment also uses a die having a flat discharge port.

  Further, the anthelmintic collar 2 according to the present embodiment may be applied by printing such a decoration by transfer as follows. That is, for example, a method in which the antiparasitic collar 2 is brought into contact with a plate on which decorations are previously formed in a multicolor multilayer, a method such as so-called pad printing, or a printing method by thermal transfer can be used.

  The decoration applied by transfer is not limited to multi-color multilayer decoration, and a pattern can be applied as decoration. Moreover, when decorating by printing by transfer, it is preferable that the material used for the anthelmintic collar 2 is a material that can adhere to the ink and can be easily printed. As such a material, for example, a resin similar to the resin used for the anthelmintic collar 2 can be used.

  The decoration of the anthelmintic collar 2 according to the present embodiment may be provided with a pattern using an image forming apparatus as follows. In the present embodiment, an ink jet printer will be described as an example of an ink jet image forming apparatus that prints an image on the anthelmintic collar 2. However, the ink jet printer that can be applied to the present invention is not limited to this, and can eject ink and print a desired image on the resin of the antiparasitic collar 2 that is a recording material. I just need it.

  The ink jet printer 12 as an image forming apparatus according to the present embodiment ejects a plurality of types of ink based on input image data, and forms an image on the resin surface of the anthelmintic collar 2. As shown in FIG. 5, the inkjet printer 12 includes a collar tray 13, a pickup roller 14, a transport roller 15, a transport guide 16, a PS roller 17, an ink discharge unit 18, a platen 19, and a drying unit 20. And a discharge roller 21 and a discharge tray 22. The inkjet printer 12 includes a control unit (not shown) that receives image data transmitted from an image processing apparatus (computer or the like) (not shown) and controls the above-described members to perform printing.

  The collar tray 13 is for accumulating the anthelmintic collar 2 for printing. It should be noted that the anthelmintic collar 2 stored in the collar tray 13 may already contain the above-mentioned medicine, or may not contain the medicine yet. The pickup roller 14 is for taking out the anthelmintic collars 2 set on the collar tray 13 one by one in accordance with a command received from the control unit.

  The conveyance roller 15 is a roller for feeding the anthelmintic collar 2 taken out by the pickup roller 14 into the conveyance path. The transport guide 16 is a table for assisting the transport of the anthelmintic collar 2 in the transport path.

  The PS roller 17 is for arranging the anthelmintic collar 2 on the conveyance path at a position suitable for printing. That is, the PS roller 17 conveys the leading end of the printing area of the anthelmintic collar 2 conveyed from the collar tray 13 to the printing start position, and temporarily stops in that state. In an image forming process described later, the anthelmintic collar 2 is set to be conveyed at a predetermined conveyance speed.

  The ink discharge unit 18 forms an image by discharging ink to the anthelmintic collar 2 that has been conveyed in accordance with a command from the control unit, and includes an ink discharge port 23 for discharging the ink. . A plurality of ink discharge ports 23 are arranged in a line corresponding to each dot constituting the image. The ink discharge unit 18 may be configured to control the image density by changing the ink discharge amount for each dot. In this case, the ink ejection unit 18 makes the amount of ink ejected from each ink ejection port 23 constant, while changing the number of ejections of each ink ejection port 23 for each dot, The total amount of ejected ink is changed for each dot.

  The platen 19 is a base for decorating (printing) the anthelmintic collar 2, and improves (maintains) the flatness of the anthelmintic collar 2 during printing. It has a function to make the interval of.

  The drying unit 20 dries the ink discharged to the anthelmintic collar 2. The discharge tray 22 is a mounting table for mounting the printed and dried anthelmintic collar 2 provided at the end of the conveyance path. Further, the discharge roller 21 is a discharge device for appropriately discharging the anthelmintic collar 2 on the end of the conveyance path to the discharge tray 22.

  The inkjet printer 12 may have a configuration in which an infrared sensor is provided on the conveyance path, and the control unit acquires information regarding the thickness of the anthelmintic collar 2 using the infrared sensor. The control unit may be configured to acquire information related to the thickness of the anthelmintic collar 2 by a user input to a key (both not shown) of an operation unit provided in the inkjet printer 12.

  Next, an image forming process for forming (printing) an image on the anthelmintic collar 2 using the inkjet printer 12 will be described.

  First, when the user (operator) places the anthelmintic collar 2 on the collar tray 13 and receives a print request including image data from a computer or the like (not shown), the control unit operates the pickup roller 14 and the transport roller 15. Then, one anthelmintic collar 2 is conveyed to the conveying path.

  The position of the anthelmintic collar 2 conveyed by the pickup roller 14 and the conveying roller 15 is adjusted so that the leading end of the image data and the leading end of the anthelmintic collar 2 are aligned in the conveying path by the conveying roller 15 and the PS roller 17. To do.

  Then, the control unit controls the ink ejection port 23 to eject ink, and forms (prints) a line image corresponding to the image data on the anthelmintic collar 2. Further, the control unit controls the transport roller 15 and the PS roller 17 while executing the formation of the line image, and transports the anthelmintic collar 2 on the transport path at a predetermined transport speed. As a result, the entire image data can be printed on the anthelmintic collar 2.

  The conveyance speed of the anthelmintic collar 2 in the ink jet printer 12 is determined by, for example, the transfer speed at which image data is transferred to the ink ejection unit 18 and the ink ejection cycle of the ink ejection unit 18 (ink ejection port 23). Alternatively, it may be set freely by the user.

  Thereafter, the control unit controls the drying unit 20 to dry the anthelmintic collar 2 and controls the discharge roller 21 to discharge the printed and dried anthelmintic collar 2 to the discharge tray 22. Thereby, a desired image (in this case, a dog picture) is printed on the surface as shown in FIG. 6, that is, an antiparasitic collar 2 with a decoration can be obtained.

  In the above description, the method for printing on one surface of the anthelmintic collar 2 has been described. However, printing may be performed on both surfaces of the anthelmintic collar 2 or on all surfaces including the side surfaces. In this case, both sides may be printed automatically, or one side (one side) may be printed. In the case of printing one side at a time, when the anthelmintic collar 2 is stored in the collar tray 13, it may be appropriately stored so that the surface to be printed is in an appropriate direction.

  The ink preferably contains an ultraviolet curable resin, and it is preferable to irradiate the image with ultraviolet light after printing an image using the ink. Thereby, since the ultraviolet curable resin can be cured, the ink can be cured, and the light resistance, impact resistance, and abrasion resistance of the printed image can be improved. The ultraviolet irradiation may be performed by the ink jet printer 12 or may be performed by using another ultraviolet irradiation apparatus after the image is printed. However, in consideration of printing efficiency, simplification of the apparatus, and cost, the inkjet printer 12 is provided with a member for ultraviolet irradiation (hereinafter simply referred to as “ultraviolet irradiation means”), and ultraviolet irradiation is performed after image formation. It is preferable to carry out continuously. In this case, it is preferable that the ultraviolet irradiation means is provided after the drying unit 20 and before the discharge roller 21 in the conveying direction of the anthelmintic collar 2.

  The ultraviolet irradiation means is not particularly limited as long as it is a member that emits ultraviolet light having a wavelength capable of curing the ultraviolet curable resin in the ink. For example, a low-pressure mercury lamp can be used as the ultraviolet irradiation means. The ultraviolet curable resin contained in the ink is not particularly limited as long as it is a resin that is cured by irradiation with ultraviolet rays. That is, the ultraviolet irradiation means and the ultraviolet curable resin may be appropriately selected so as to be a combination capable of curing the ultraviolet curable resin in the ink.

  Further, in order to more effectively prevent ink bleeding and peeling due to the sustained release of the medicine, it is preferable to preheat the anthelmintic collar 2 before printing. The heating temperature may be appropriately changed according to the type of resin composition to be used and the type of ink. For example, it is preferably within a range of 30 ° C. or higher and 50 ° C. or lower, and preferably 40 ° C. More preferred.

  Next, the manufacturing method of the blister package which accommodated the anthelmintic collar 2 formed in this way in the blister packaging container 1 will be described.

  The blister package manufacturing apparatus according to the present embodiment is an apparatus for thermally bonding the mount 3 and the blister member 4 by an impulse sealing method. As shown in FIG. 7, a pressurizing device 24, a heating device 25, and the like. It consists of The pressurizing device 24 presses the mount 3 placed on the blister member 4 set in the heating device 25.

  The heating device 25 has a structure in which a seal die 27 is placed on a placing table 26, and the collar portion 4 b of the blister member 4 set on the heating device 25 is heated and adhered to the mount 3. It has become.

  As shown in FIG. 8, the seal mold 27 includes a substantially rectangular parallelepiped base 32 made of a phenol resin in which a plurality of openings 29 are formed so that the accommodating portions 4 a of the blister members 4 can be accommodated, and the base 32 And a plurality of heaters 28 for heating the bonding portion of the blister member 4. The heater 28 is disposed along the outer peripheral edge of the opening 29 formed along the shape of the blister member 4.

  The heater 28 has heating parts (first heating part 28a, second heating part 28b) having substantially the same width as the brim part 4b of the blister member 4, and the first heating part 28a and the second heating part 28b The entire surface of the collar portion 4b is configured to be heated.

  The first heating unit 28a and the second heating unit 28b are each made of a nichrome wire. The nichrome wire is connected to an electric wire 31 connected to an electrode 30 provided on the seal mold 27, and is heated by an electric current supplied from the electrode 30 and flowing through the electric wire 31. At this time, the heater 28 is heated by causing an electric current to flow instantaneously, and the collar portion 4b of the blister member 4 is instantaneously heated and melted to be thermally bonded to the mount 3. For example, a current of 8 Amp flows through the nichrome wires of the first heating unit 28a and the second heating unit 28b for 5 seconds.

  Moreover, the nichrome wire which comprises the said 1st heating part 28a and the 2nd heating part 28b is comprised so that the electric current supplied from the electric wire 31 may flow in parallel. That is, the nichrome wire constituting the first heating unit 28 a and the nichrome wire constituting the second heating unit 28 b are configured not to be in electrical contact within the heater 28. For this reason, in the heater 28, the discontinuous part 28c from which a nichrome wire becomes discontinuous is formed in the edge part of the 1st heating part 28a and the 2nd heating part 28b. There are two discontinuous portions 28 c for one heater 28. That is, in the heater 28, the heating part is formed discontinuously.

  By the way, in the heater 28, since the nichrome wire is discontinuous in the heating part, the heat amount to the collar part 4b of the blister member 4 is insufficient in the discontinuous part 28c, and an unbonded part between the collar part 4b and the mount 3 is formed. May occur. When there is an unbonded portion in this manner, the bonded portion between the blister member 4 and the mount 3 becomes discontinuous, and the barrier property in the blister packaging container 1 is reduced.

  Therefore, in the heater 28 having the above-described configuration, the first heating unit 28a and the second heating unit 28b are arranged as close as possible. Thereby, the heat quantity which is insufficient for the collar part 4b corresponding to the discontinuous part 28c can be compensated by the heat generated from the respective end parts of the first heating part 28a and the second heating part 28b. Therefore, the adhesion part of the mount 3 and the collar part 4b can be made continuous.

  Further, in order to increase the amount of heat in the discontinuous portion 28c, for example, as shown in FIG. 9, a heater support member 33 is disposed as a good thermal conductor between the end portions of the first heating portion 28a and the second heating portion 28b. Can be considered. That is, the heat generated in the first heating unit 28a and the heat generated in the second heating unit 28b are conducted to the heater support member 33, and the collar portion 4b of the blister member 4 corresponding to the discontinuous portion 28c is heated. It becomes like this.

  Thereby, since the heat quantity which can be thermally melted can be supplied to the collar part 4b corresponding to the discontinuous part 28c, the discontinuous part of the adhesion part of the collar part 4b can be eliminated without fail, and the blister packaging container 1 The barrier property can be further improved.

  Further, as described above, since the first heating unit 28a and the second heating unit 28b constituting the heater 28 are discontinuous, the constituent members of the heater 28, such as nichrome wire, can be reduced, As a result, a blister package manufacturing apparatus can be produced at low cost.

  From the above, in the blister package manufacturing apparatus having the above-described configuration, first, the blister member 4 is set in the opening 29 of the seal mold 27, and the anthelmintic collar 2 is placed inside the blister member 4. Subsequently, the mount 3 is placed so as to cover all the blister members 4 and is pressurized with a predetermined pressure by the pressure device 24. At this time, in the heating device 25, a current is passed from the electrode 30 to the first heating part 28a and the second heating part 28b of the heater 28 for a predetermined time, and the collar part 4b of the blister member 4 is transferred from the collar part 4b to the mount. 3 is instantaneously heated and melted.

  As described above, the blister package manufactured as described above has a continuous adhesive portion between the mount 3 and the collar portion 4b, so there is no leakage of gas from the bonded portion. Since both the blister member 4 is made of a thermoplastic resin having a barrier property, there is no gas leakage from the mount 3 and no gas leakage from the blister member 4, and the gas barrier is excellent. It is excellent in nature.

  Therefore, the blister packaging container 1 of the present application is suitable for encapsulating a material containing a transpirable material such as an anthelmintic collar 2 as an inclusion to be packaged.

  That is, if airtightness is high in this way, when the inclusion contains a transpiration substance, the transpiration substance does not evaporate from the blister packaging container 1, so the quality of the inclusion is reduced until the blister packaging container 1 is opened. It will not let you.

  In particular, in the blister package manufactured by the manufacturing method according to the present embodiment, the antiparasitic collar 2 which is the package of the blister package 1 is a decorated collar as described above. Therefore, unlike the monochromatic anthelmintic collar conventionally stored in the blister packaging container, it is possible to provide the anthelmintic collar 2 having a great variety. Furthermore, as above-mentioned, since the blister packaging container 1 can confirm the to-be packaged object from the outside, the selection range of the user who needs the collar 2 for anthelmintic can be expanded. Therefore, in recent years, there is an effect that it is possible to meet the demands of users who keep various animals as pets.

  The present invention is not limited to the above-described embodiments, and various modifications can be made within the scope shown in the claims. That is, embodiments obtained by combining technical means appropriately changed within the scope of the claims are also included in the technical scope of the present invention.

  The blister package of the present invention and the method for producing the blister package can be used for a resin containing a transpirationable drug, and can be particularly suitably used as an animal anthelmintic collar.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 shows an embodiment of the present invention, and is a perspective view showing a schematic configuration of a blister package in which a deworming collar is housed in a blister package container. It is explanatory drawing in the middle of taking out the collar for antiparasitics which peeled off the collar part of the blister member from the base_sheet | mounting_paper in the blister package shown in FIG. It is sectional drawing of the adhesion part of the blister member of the blister packaging container of the blister packaging body shown in FIG. It is the top view to which the plane of the anthelmintic collar of the blister package shown in FIG. 1 was expanded. (A)-(d) is the schematic of the process of manufacturing the collar for antiparasitics of the blister package shown in FIG. 1 with an injection molding machine. FIG. 2 shows an embodiment of the present invention, and is a schematic view of an extrusion molding machine that is an apparatus for producing an anthelmintic collar for the blister package shown in FIG. 1. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 illustrates an embodiment of the present invention and is a schematic diagram illustrating a schematic configuration inside an ink jet printer. It is the top view to which the plane of the anthelmintic collar printed by the inkjet printer shown in FIG. 7 was expanded. It is a schematic block diagram of the manufacturing apparatus which manufactures the blister package shown in FIG. It is a schematic structure perspective view of the heating apparatus with which the manufacturing apparatus shown in FIG. 9 is equipped. It is AA arrow sectional drawing of the heater of the heating apparatus shown in FIG.

Explanation of symbols

1 Blister packaging 2 Collar for anthelmintic insect 3 Mount (seal member)
4 Blister member 4a Storage part (storage part)
5 Paper base 6 Gas barrier layer (barrier layer)
7 Polyolefin layer (adhesive layer)
8 Laminated film (film layer)
9 PET layer 10 First resin (region)
11 Second resin (region)
12 Inkjet printer (image forming device)
34 Injection molding machine 48 Extrusion molding machine

Claims (12)

An anthelmintic collar formed using a resin containing a transpirationable plasticizer, a blister member having a transmission barrier property and a light transmission property, and having a storage portion in which the anthelmintic collar is stored, and a paper base material A sealing member in which a barrier layer having a transmission barrier property and an adhesive layer are laminated in this order, and the blister member and the sealing member are mutually connected in a state where the anthelmintic collar is stored in the storage portion. A bonded blister pack,
A blister package characterized in that at least a part of the anthelmintic collar is decorated with two or more colors.   The blister package according to claim 1, wherein the blister member has a film layer made of a material having an easy peel property with respect to the adhesive layer.   The blister package according to claim 1 or 2, wherein the resin is at least one resin selected from the group consisting of a thermoplastic resin, a thermosetting resin, a synthetic rubber, and a thermoplastic elastomer.   The blister pack according to any one of claims 1 to 3, wherein the anthelmintic collar has a plurality of regions of different colors.   The said area | region consists of a mutually different material for every color, The blister package body of Claim 4 characterized by the above-mentioned. A blister member having a transmission barrier property and a light transmission property, and having a storage portion for storing an anthelmintic collar, and a sealing member provided with a barrier layer having a transmission barrier property and an adhesive layer on a paper base material A method for producing blister packs that adhere to each other,
The blister member in a state in which an anthelmintic collar formed by using a resin containing a transpirationable plasticizer and decorated with at least a part of two or more colors is accommodated in the accommodating portion. A method of manufacturing a blister package, wherein the sealing member and the sealing member are bonded to each other.   The method for producing a blister package according to claim 6, wherein the decoration is applied using an inkjet image forming apparatus. Applying the decoration using an ink containing an ultraviolet curable resin,
9. The method for producing a blister package according to claim 8, wherein after the decoration is applied, ultraviolet light is irradiated to the decorated part.   The method for producing a blister package according to any one of claims 6 to 8, wherein the molded resin is heated before applying the decoration.   The method for producing a blister package according to claim 6, wherein the decoration is applied by using an extrusion molding machine that supplies a plurality of resins individually and joins and shapes the plurality of resins while being extruded.   The method for producing a blister package according to claim 6, wherein the decoration is applied using an injection molding machine that individually injects and molds a plurality of resins.   The method for producing a blister package according to claim 6, wherein the decoration is applied by transfer.

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