JP2006063038A - Antiaging composition, cosmetic containing the same, and food and drink containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a composition having an antiaging function, to prepare a cosmetic containing the same, and to provide food and drink containing the same. <P>SOLUTION: The antiaging composition contains an extract of Eutrema wasabi and an extract of Juncus effusus as essential components. The composition may further contain an extract of Mallotus philippinensis. The composition may furthermore contain an extract of a plant selected from Aloe vera, Momordica grosvenorii, Eucommia ulmoides, Lepidiummee yenii, Avena sativa, Gentianella alborocea, Hibiscus sabdariffa, Anethum graveolens, Calendula officinalis, Euphoria longana, Foeniculum vulgare, Thea sinensis, Mentha pulegium, Urtrica thunbergiana, Areca catechu, Fagopyrum tartaricum, Uncaria gambir, and Terminalia arjuna of a combretaceous plant. The cosmetic and the food and drink contain the antiaging composition, respectively. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a composition having an anti-aging function, and a cosmetic and a food and drink containing the composition.

Wasabi: Yam is a perennial plant belonging to the Brassicaceae family. It is native to Japan and grows naturally on the banks of mountain streams. The rhizomes are thick and cylindrical, and have a strong pungent taste along with the petiole. The roots are pickled with spices and leaves. Wasabi not only dissipates and sterilizes the toxins in the gastrointestinal tract, but its pungent taste helps to prevent the oxidation of vitamin C, which is contained in large amounts, and stimulates the gastrointestinal mucosa to increase appetite and improve physical fitness. It is said that it is improved and the youth of men and women is an elite. Wasabi is made from ω-methylthioalkyl, allyl mustard oil, methyl mustard oil, isopropyl mustard oil, sec-butyl mustard oil, 3-butenyl mustard oil, 4-pentenyl mustard oil, 5-hexenyl mustard. Oil, hexyl mustard oil, β-phenethyl mustard oil, 6-heptenyl mustard oil, and other mustard oils are included, and these effects suppress platelet aggregation in the blood and prevent blood clotting. It is said.

In addition, raw wasabi has the bactericidal power next to the large intestine, and it has been scientifically proven that a drop of raw wasabi has the ability to sterilize cholera, typhoid, dysentery, streptococci, E. coli, etc. in just 3 minutes. . Also,
Recently, research on mold prevention and anti-corruption has been conducted using wasabi. If you put a little wasabi in a bag of mold such as mold that is easy to mold, mold will be prevented. Antibacterial activity against wasabi pathogenic Escherichia coli O-157 and bacteria caused by food poisoning has also been confirmed. Wasabi's antibacterial activity, especially its antifungal activity, is stronger than expected. The pungent component allyl mustard oil, which is the main antibacterial activity of wasabi, is volatile. Bactericidal effect can be seen even in the presence of oil of only 1/500 cc of allyl equivalent to approximately 1 g of wasabi, and the number of 0-157 bacteria is reduced to about 1/8 after 1 hour and to 1/20 after 4 hours There is also a report that it was decreasing.

Next, the following can be found in the patent literature.
Japanese Patent Application Laid-Open No. 2004-2237 (Patent Document 1) includes phenylpropanoid, monoterpenoid, sesquiterpenoid, triterpenoid, coumarin, isocoumarin, chroman, chromene, taroquine, tannin and lignan. An anti-aging food or medicament for humans or animals, comprising an herb containing one or more herb components selected from the group consisting of systems and / or processed products thereof.

An anti-aging food or medicine for humans or animals, wherein the herb component is one or more selected from the group consisting of anethole, eugenol, camphene, geraniol, cineol and thymol. Herbal ingredients are isoeugenol, estragole, carvacrol, carvone, camphor, coumarin, glycyrrhizin, glycyrrhizic acid, curcumin, sapinene, salicylaldehyde, citronell, synamic aldehyde, cymene, gingiverene, tsuyoshi, terpineol, nerol, vanillin, ferrandrene An anti-aging food or medicine for humans or animals, which is one or more selected from the group consisting of: borneol, methylshavicol, menthol, menthone, linalool and limonene. An anti-aging food or medicine for humans or animals, wherein the concentration of the herb or / and processed product thereof in the food or medicine is 0.001 to 5.0% by weight. Aging prevention consists of blur prevention, learning function improvement, memory improvement, baldness prevention, hair gloss retention, hair and skin roughening prevention, skin drooling prevention, dripping prevention of the retina, and spine flexion prevention. An anti-aging food or medicament for humans or animals, which is one or more selected from the group.

The herb is one or more selected from the group consisting of rice, asteraceae, perilla, ginger, celery, peach, pea, citrus, magnolia and lily Anti-aging food or medicine for humans or animals. The herb is selected from the group consisting of Asaaceae, Gramineae, Asteraceae, Camphoraceae, Lamiaceae, Gingeraceae, Seriaceae, Sycaenidae, Myrtaceae, Leguminosae, Citrus, Magnolia, Lilyaceae and Orchidaceae Anti-aging food or medicine for humans or animals characterized by one or more kinds. Herbs are asahi, anise, ajowan, allspice, oregano, cassia, camomile, garlic, cardamom, licorice, catnip, caraway, cumin, clove, poppy seed, pepper, sesame, coriander, saffron, savory, sunflower, Perilla, cinnamon, ginger, star anise, spearmint, sage, celery, thyme, dill, turmeric, tarragon, chili pepper, chilli, nutmeg, vanilla, basil, parsley, fenugreek, fennel, peppermint, horseradish, hop, marjoram, A human or one or two or more kinds selected from the group consisting of mustard, mace, eucalyptus, lavender, rice cake, lemon balm, rosemary, laurel and wasabi Anti-aging food or medicament for the object is disclosed.

Japanese Patent Application Laid-Open No. 2001-122765 (Patent Document 2) includes hibiscus, aloe, daiou, yellow spirit, walrus, proliferating grass, sushishi, salmon plum, kudzu, saiko, nematode, sojutsu, thin leaf, bukuryo, licorice, peonies, Pepper, semi-summer, toki, cinnamon, ten-drug, yellow ream, peony, gentian, pentaploid, assembly, ganoderma, hemp, jaundice, apricot kernel, psoriasis, Taisou, Ogon, Chen skin, turmeric, Shinobu, Kyoujitsu, ground yellow, Garlic, sage, oregano, rosemary, laurel, celery, thyme, tarragon, onion, nutmeg, mace, clove, wasabi, sabor, basil, chili, bean tea, black tea, green tea, bamboo leaf, coffee, too much, bee , Wormwood, bear sasa, wolfberry, yabusotetsu, shiitake mushroom, ginkgo, hijiki, squirrel, kombu, give-up Any one of a group of various plant extracts extracted from each plant composed of sea turtles with water or a lower alcohol or a lower alcohol aqueous solution, and a compound group composed of tannic acid, 2-hydroxy-4-methylbenzophenone-5-sulfate An active oxygen scavenger characterized by containing one or more selected from the above group or both groups as an active ingredient. A cosmetic comprising an active oxygen scavenger as an active ingredient is disclosed.

JP-A-2001-64253 (Patent Document 3) discloses an activity inducer of glutathione-S-transferases comprising ω-methylsulfinylalkylisothiocyanate. However, the carbon number of the alkyl group is 5-8. An activity inducer of glutathione-S-transferase, wherein ω-methylsulfinylalkylisothiocyanate is an extract from a cruciferous plant. An activity inducer of glutathione-S-transferase has been disclosed, wherein the cruciferous plant is wasabi or watercress.

GST is an enzyme for conjugating reduced glutathione and various electrophilic compounds, specifically, an enzyme that catalyzes the conjugation reaction between xenobiotics and glutathione, and is one of the second phase foreign substance metabolizing enzymes. A multi-functional enzyme consisting of molecular species with different functions. That is, it retains the function as a detoxifying enzyme, for example, the function of conjugating various exogenous organic compounds to glutathione, and also the function of a binding protein that binds bile acids, bilirubin, steroid hormones, etc. . In addition, lipids constituting the living body or lipids ingested as a diet are automatically oxidized in the body to become peroxides, which are further oxidized to oxidation products such as 4-hydroxynonenal. . These lipid peroxides and oxidation products, especially oxidation products, are the causative substances that damage DNA and biological tissues, induce various diseases such as arteriosclerosis and Alzheimer, and promote aging of living organisms. I know that.

This is what is called oxidative stress. GST catalyzes the conjugation of these lipid peroxides and oxidation products, detoxifies them and facilitates their discharge outside the body. If the activity of such GST is further improved or increased, the above-described second phase conjugation reaction is further activated. As a result, the detoxification and metabolic functions of xenobiotics such as carcinogens are improved and carcinogenesis is prevented. Risk will be reduced. Furthermore, oxidative stress due to lipid oxidation products can be further reduced by improving and increasing the activity of GST, and as a result, arteriosclerosis and Alzheimer caused by lipid oxidation products are effectively prevented. Yes.

In Japanese Patent Application Laid-Open No. 2000-169382 (Patent Document 4), broccoli, cauliflower, kale, nazuna, suzushiro, hazaza, tadashi, taiji, daboshi nana, yagarashi, and garashi , Takana, Karashina, Wasabi, Yuri Wasabi, Hinano, Sakikina, Turnip, Cabbage, Spinach, Komatsuna, Celery, Parsley, Lettuce and Apple A pharmaceutical composition for preventing or treating allergies, a food material for preventing allergy, a pharmaceutical composition for preventing atopic dermatitis, and a cosmetic composition having an effect of improving rough skin are disclosed.

In Japanese Patent Application Laid-Open No. 11-269082 (Patent Document 5), broccoli, Nazuna, Suzushiro, Hatazao, Tagarashi, Taisei, Obata Tsubaki, Yamagata, Arashira, Takana, Human serum cholesterol containing at least one selected from the group consisting of mustard, wasabi, yuriwasabi, hanasai, hinano, sukikina, turnip, nabana, cabbage, mekibetsu, radish and radish leaves Food with a lowering effect. (A) One or more selected from the group consisting of cabbage, mecabetsu, radish, radish leaves, and (B) broccoli, nazuna, suzushiro, hazazao, tadashi, taiji, and bonito One, two or more selected from the group consisting of: na, Yamagarashi, Ogarashi, Takana, Karashina, Wasabi, Yuri Wasabi, Hakusai, Hinona, Immediately, Turnip and Oil A food containing human serum cholesterol lowering effect. (a) broccoli, (b) at least one selected from the group consisting of cabbage and radish leaves, and (c) one or more selected from the group consisting of celery, lettuce, spinach, komatsuna, parsley and apple , A food having a human serum cholesterol lowering effect. Broccoli, Nazuna, Suzushiro, Hatazao, Tagarashi, Taisei, Obata Netsubana, Yamagarashi, Araragarashi, Takana, Karashina, Wasabi, Yuri Wasabi, Hakusai, Hinano, A prophylactic or therapeutic agent for human hypercholesterolemia, comprising one or more selected from the group consisting of immediately, turnip, turnip, oil, cabbage, mekibetsu, radish and radish leaves.
Broccoli, Nazuna, Suzushiro, Hatazao, Tagarashi, Taisei, Obata Netsubana, Yamagarashi, Araragarashi, Takana, Karashina, Wasabi, Yuri Wasabi, Hakusai, Hinano, A human arteriosclerosis preventive or therapeutic agent containing one or more selected from the group consisting of Sakina, Turnip, Abura, Kyabatsu, Mekibetsu, Daikon and Radish leaves is disclosed.

However, none of these documents has been considered in depth, focusing on the prevention of aging. In other words, the phenomenon of aging needs to be grasped from various aspects and completed as a composition that can be expected to have a comprehensive effect.

That is, with regard to aging prevention, in general terms, Measures against ultraviolet rays (most important) are important. This is because UVA reaches the dermis of the skin (where collagen is made) and creates deep wrinkles. 2. Prevent dryness (dry skin). This is because it removes moisture from the skin, becomes thick, and causes wrinkles. 3. Reduce stress as much as possible. This is because it adversely affects the functioning of the independent nerves and makes metabolism worse. 4). Avoid lack of sleep. Regeneration of skin cells. This is because the repair is not performed smoothly. 5. Eliminate hormonal abnormalities. This is because it becomes easier to cause spots when the secretion of progesterone becomes active. 6). Don't have a biased diet. This is because a poorly balanced diet, especially vitamin deficiencies, is not good. Thus, in order to prevent aging, it is basically necessary to eliminate complicated factors, and this problem cannot be completely solved with one technique. The inventors have: 1. In regard to, we have already proposed technical solutions in Japanese Patent Application Nos. 2004-220376 and 2004-220442. 3. In the Japanese Patent Application 2004-227392, a technical solution was proposed. 4). In regards to the above, technical solutions were proposed in Japanese Patent Application Nos. 2004-219374, 2004-219377, and 2004-219382. 5. The problem is very medical and the inventors have not yet found a technical solution. 6). Is to be carried out through the daily research and efforts of each person. Therefore, the present inventor specifically stated in this application 2. Is a matter of discussion.

The skin is divided into three parts: the outermost epidermis, the dermis with blood vessels and nerves, and the subcutaneous tissue mainly made of fat. Of these, the dermis is deeply involved in skin firmness. In the dermis, fibrous proteins called collagen and elastin are entangled like a mesh.
These two kinds of substances play the role of a spring that gives the skin firmness. However, active oxygen is generated due to ultraviolet rays, stress, lack of sleep, or imbalance between smoking, intense exercise, and diet. This active oxygen originally has the function of sterilizing and disinfecting substances that adversely affect the human body such as bacteria and toxins, but if excessive active oxygen is generated due to the above factors, it causes damage to skin cells and causes aging It becomes. This active oxygen also causes cancer, diabetes, dementia and the like.

In addition, scavengers (chemical substances called “antioxidants”: substances that reduce active oxygen and protect normal cells) that are present in cells gradually decrease when they are over 25 years old. It becomes quantity.
The active oxygen generated in this way gradually destroys the structure of collagen and elastin.
For this reason, the elasticity and elasticity of the skin will be lost with age.

Although it is impossible to completely prevent aging,
It is possible to slow down the aging speed by taking countermeasures. For example, the biggest factor in the aging mechanism is the collapse of the structure of collagen and elastin that maintain the firmness and elasticity of the skin.
And the cause of this collapse is that the active oxygen born from ultraviolet rays and stress is bad. Therefore, for skin that has already begun to age, 1. 1. Supplement with collagen and elastin 2. Recover damage by supplementing antioxidants, etc., and prevent generation of active oxygen that promotes aging as an aging prevention. 3. UV prevention measures 4. enough sleep, Measures such as stress relief are effective.

Among the damage recovery measures, collagen and elastin can be consumed in large quantities from food such as meat, fish skin, streaks, and cartilage. Many supplements containing these are also commercially available. The effect of preventing aging by applying to the outside is not perfect. On the other hand, antioxidants, chemical substances that contain active oxygen in the skin, can be applied to the skin as cosmetics.
It can be replenished from two methods of taking in tablets such as meals and supplements. For example, an ingredient that can be applied as a cosmetic product or used as a supplement in tablets, OPC (oligomeric proanthocyanidins)
There is a substance called. This substance is known to have 20 times the antioxidant effect of vitamin C. Other antioxidants that can be taken from food include: (The food in parenthesis contains those antioxidants)

1. Vitamin C (tomato, strawberry, broccoli, etc.)
2. Vitamin E (beans, sesame seeds, pumpkins, persimmons, sardines, etc.)
3. Beta carotene (carrot, cabbage, spinach, etc.)
4). Selenium (garlic, onion, egg, bonito, etc.)
5. Polyphenol (wine, apple, cocoa, banana, etc.)
6). Lycopene (tomato, watermelon, grapefruit, etc.)
However, eating these foods every day is particularly difficult for middle-aged women who are busy. In such a case, it is very effective to take in supplements, and it is also effective to use effective cosmetics.
It is an eternal desire of many women to want to have clean skin forever.

Recent findings include: Tea that contains a lot of β-carotene has the effect of preventing skin aging. 2. As research on the beauty effects of sake has progressed, it has become clear that sake contains ingredients that are thought to prevent cellular aging. A component called “kojic acid” contained in rice bran is a substance having an action of preventing and activating cell aging. 3.
“Astaxanthin” is a red carotenoid that is a member of the same carotenoids as β-carotene and is abundant in seafood such as salmon, shrimp, crabs, and seaweed. Its antioxidant power is “500 to 1000 times that of vitamin E”. It is said that the active oxygen of blood lipids is suppressed, blood vessels are kept youthful, and immune cells are protected from active oxygen to enhance immunity. In addition, it has been clarified that skin aging is prevented by suppressing active oxygen, which is said to be the cause of spots and wrinkles.

In addition, Meshimakobu is safe enough to be certified as a food, has an immune effect and anti-cancer effect, and is expensive because it takes quite a long time to grow, but it is a non-irritating nutrient, so acne, stains and freckles Improve skin, prevent rough skin, promote blood circulation and metabolism, and lead to skin moisturizing and whitening effects. In addition, prevent skin aging.

Chondroitin is a kind of mucopolysaccharide. It is similar in function to female hormones (estrogens) and is said to be a similar estrogen. It forms connective tissue together with collagen to prevent aging and whiten, and to maintain water retention in tissues so that somatic cells can exist normally. Give elasticity.

Carrot root extract increases metabolism and makes your skin more lively.

Cyclomethicone is a volatile oily component that has a light and refreshing feel and has a function of suppressing stickiness. It is used in hair care products, skin care products, and makeup products in general.

The ginseng extract is the most effective ginseng produced in 6 years, but the root extract has long been used as a traditional Chinese medicine and a folk medicine to relieve fatigue. It has been reported that the skin has blood circulation promotion, active oxygen elimination, and antioxidant effects, and prevents skin wrinkles and sagging.

Chamomile extract is rich in azulene and has anti-inflammatory and analgesic effects. It also promotes blood circulation of peripheral blood vessels and promotes metabolism of the scalp. Since it has anti-allergic and sedative effects, it is effective for atopy, sensitive skin, and dry skin. There is also a scenting action to remove fatigue.

One of the other points to prevent aging is growth hormone. Although it is officially called human growth hormone, it is the most important hormone in human life activity that is produced and secreted by the pituitary gland. Growth hormone secretion is high in newborns and decreases from around 20 years old. People who have less reduction are more youthful and have firmness and moisture. On the other hand, the more people who decrease, the aging progresses, and wrinkles and spots appear more on the skin. Therefore, people who are aging may have a decrease in growth hormone. There are treatments that supplement growth hormone, but in the United States and elsewhere, various adverse effects have been reported recently, and the cost is high.

However, if you drink maca containing a lot of arginine, you can increase growth hormone by yourself without relying on such artificial treatment. There are also reports that your body can stimulate the secretion of growth hormone by itself, preventing aging and promoting rejuvenation. Arginine is an essential amino acid essential for the production of growth hormone, but according to a study by the American Plant Treatment Center, the content of arginine (per 100g) is 2600mg for soybeans, 1500mg for chicken fillet, and 9940mg for maca. In other words, arginine is about 3.8 times that of soybeans and about 6.6 times that of chicken fillet.

From the viewpoint of preventing aging, the following can be cited from a wide range of patent documents.

JP-A-2004-131431 (Patent Document 6) contains a saponin derived from soybean, and a composition for preventing or improving ultraviolet ray injury. A composition for preventing or improving ultraviolet ray injury, comprising a kale and / or an extract thereof. A composition for preventing or improving ultraviolet ray injury, comprising a component having a proteasome activity promoting action. Disclosed is a composition for preventing skin aging caused by ultraviolet rays, which comprises a component having a proteasome activity promoting action.

Japanese Patent Application Laid-Open No. 2004-129663 (Patent Document 7) describes a blend,
(I) ximenic acid obtained from natural substances or alkyl esters or glycerol esters or wax esters thereof or food-acceptable salts of 0.1 to 99.9% by weight, preferably 1 to 99% by weight, most preferably 2 -98% by weight and (ii) other fatty acids or glycerides, especially triglycerides 0.1-99.9% by weight, preferably 1-99% by weight, most preferably 2-98% by weight, in which case these are xymenin A blend containing xymenic acid, its alkyl ester or glycerol ester or wax ester or food acceptable salt thereof, and glycerides, including dissimilar to those present in the natural substance of the acid.
The component (i) of the blend contains nervonic acid, and the mass ratio of ximenic acid and nervonic acid in the blend is 0.5 to 5.0, preferably 0.75 to 4.0. A blend, most preferably 1.2-3.5.
At least 15% by weight of xymenic acid or its alkyl ester or glycerol ester or wax ester or salt, preferably at least 20% by weight of ximenic acid and at least 0.5% by weight of nervonic acid or its alkyl ester or glycerol ester or wax ester Or a concentrate of ximenic acid or its alkyl ester or glycerol ester or wax ester or salt thereof in glycerides having at least 5% nervonic acid or a derivative thereof, or a salt thereof.
Other glycerides or derivatives thereof are coconut oil, cocoa butter, coconut oil, coconut shell oil, CLA-glycerides, soybean oil, olive oil, sunflower oil, rapeseed oil, safflower oil, corn oil, cottonseed oil, cocoa butter equivalent or cocoa Avatar substitutes, fish oil, borage oil, pine nut oil, coriander oil, fungal oil, or their high olein mutants or fractions thereof, or these cured mutants or fractions of cured mutants, or these oils And a blend containing one or more mixtures of fats or other glycerides selected from the group consisting of these free fatty acids or free CLA acids.
Blend, at the indicated temperature, non-stabilized was measured on blend by _NMR, N 5 = 5 to 80, preferably 10 to 70, and less than _N 35 = 20, preferably 1 to 5 of the solid fat content Indicates a blend.
A food composition, preferably a fat-based composition, is margarine, fat phase or water phase or two phase spread, low fat spread, confectionery such as chocolate or chocolate coating or chocolate filling or bread ingredients, ice cream, A food selected from the group consisting of ice cream coatings, ice cream inclusions, dressings, mayonnaise, cheese, cream substitutes, dry soups, beverages, cereal bars, sauces and snack bars.
At least one of the following health benefits:
i) Weight loss or regulation ii) Prevention or treatment of insulin resistance or related diseases such as diabetes iii) Delayed onset of symptoms associated with the development of Alzheimer's disease iv) Improved memory function v) Blood lipid levels Reduced vi) Anti-cancer action vii) Ximeninic acid, its alkyl ester, glycerol ester, wax ester or its food-acceptable salt for producing a food composition or food supplement having skin aging prevention effect The use of compositions containing as active ingredients is disclosed.

JP-A-2004-91397 (Patent Document 8) discloses a composition for preventing skin aging comprising one or more selected from silymarin, flavonol compounds, stilbene compounds and vitamin Ps. A composition for preventing skin aging comprising one or more selected from plants or plant extracts containing silymarin, flavonol compounds, stilbene compounds or vitamin Ps is disclosed.

JP-A-2004-83416 (Patent Document 9) contains a substance having a collagen production promoting action and / or hyaluronic acid production promoting action as an active ingredient. A substance having a collagen production promoting action and / or a hyaluronic acid production promoting action is known to be used in the kite mikan Citrus hystix A. An anti-aging agent characterized by being an extract from DC. A skin external preparation characterized by containing an anti-aging agent. A food or drink characterized by containing an anti-aging agent. An anti-aging method characterized by ingesting a substance having a collagen production promoting action and / or hyaluronic acid production promoting action is disclosed.

JP-A-2004-10559 (Patent Document 10), a cell activator as an active ingredient Kaurerupa racemosa (Caulerpa racemosa) algal extracts. Antioxidant as an active ingredient Kaurerupa racemosa (Caulerpa racemosa) algal extracts.
Kaurerupa racemosa (Caulerpa racemosa) skin external agent for aging and skin roughness improvement containing algal extract. Kaurerupa racemosa (Caulerpa racemosa) food for aging and skin roughness improvement containing algal extract is disclosed.

JP-A-2003-342179 (Patent Document 11) discloses a matrix metalloproteinase inhibitor containing one or more selected from the group consisting of kale, broccoli, cauliflower or an extract thereof. An anti-aging agent comprising a matrix metalloproteinase inhibitor. A food composition comprising a matrix metalloproteinase inhibitor is disclosed.

Japanese Unexamined Patent Publication No. 2003-306446 (Patent Document 12) includes an external preparation containing an antioxidant component and an internal preparation containing an antioxidant component, and an anti-aging agent for skin and / or improving acne. Agent kit. A skin anti-aging agent and / or acne improving agent kit, wherein the antioxidant component is at least one selected from the group consisting of parsley, tea, yeast, wheat germ and extracts thereof.
A skin aging inhibitor and / or acne improving agent kit, wherein the antioxidant component is vitamin E and / or a derivative thereof. Skin anti-aging agent and / or acne-improving agent kit, characterized in that antioxidant component contained in external preparation is parsley extract and / or tea extract, and antioxidant component contained in internal use is tocotrienol . A food composition comprising carotenoid, vitamin C or a derivative thereof, tocotrienol and Centella asiatica or an extract thereof is disclosed.

JP-A-2003-300893 (Patent Document 13) contains an extract from the fruit of star fruit (Averrhoa carambola L.) as an active ingredient.
Star fruit (Averrhoa
An antioxidant comprising an extract from the fruit of carambola L.) as an active ingredient. An antioxidant, wherein the extract has an active oxygen scavenging action and / or a radical scavenging action. An anti-aging agent comprising an extract from the fruit of star fruit (Averrhoa carambola L.) as an active ingredient.
An anti-aging agent is disclosed, wherein the extract has one or more actions selected from the group consisting of hyaluronic acid production promoting action, elastase inhibitory action and collagenase inhibitory action.

JP 2003-252778 A (Patent Document 14) discloses a hyaluronidase inhibitor containing an acetone-insoluble component of an organic solvent extract derived from cereals as an active ingredient. A hyaluronidase inhibitor whose cereals are beans, rice, wheat, corn or rape. A hyaluronidase inhibitor whose acetone insoluble component is unsaponifiable. A hyaluronidase inhibitor obtained by separating an acetone-insoluble component from a saponification-treated product of an organic solvent extract derived from cereals. A hyaluronidase inhibitor having a skin aging preventive action, an anti-inflammatory action or an antiallergic action. Cosmetics, foods and drinks or pharmaceuticals containing hyaluronidase inhibitors are disclosed.

JP-A 2003-252777 (Patent Document 15) discloses an elastase inhibitor, which is an organic solvent extract derived from cereals and contains an unsaponifiable alcohol-soluble component as an active ingredient. The unsaponifiable alcohol-soluble component has an Rf value of 0.4 to 0.9 in thin layer chromatography (developing solvent: chloroform: methanol: water = 40: 10: 1 (V / V / V)). An elastase inhibitor. An elastase inhibitor, wherein the non-saponifiable alcohol-soluble component is obtained by fractionating an alcohol extract from a saponified product of an organic solvent extract derived from cereals. An elastase inhibitor having skin aging preventive properties and / or anti-inflammatory properties. Cosmetics, foods and drinks or pharmaceuticals containing an elastase inhibitor are disclosed.

Japanese Patent Application Laid-Open No. 2003-238432 (Patent Document 16) includes aloe vera, rakanka, eucommia, maca, oat, elcumburi, karkade, dill, milkfish, longannik, fennel, cha, penny royal mint, nettle, areca, tartary buckwheat. The Acacia catechus, Terminaria Arjuna (Terminalia)
hyaluronic acid accumulation promoter containing at least one member selected from the group consisting of arjuna). A composition for improving skin wrinkles, moisturizing skin and / or preventing skin aging comprising a hyaluronic acid accumulation promoter is disclosed.

JP 2003-183173 A (Patent Document 17) includes Nyctanthes albortristis, Piper chaba, Anthocephalus indicus and Crotalariacytisoides. A collagen production promoter comprising, as an active ingredient, an extract from one or more plants selected from the group consisting of: From one or more plants selected from the group consisting of Nyctanthes albortristis, Piper chaba, Anthocephalus indicus and Crotalariacytisoides The hyaluronic acid production promoter characterized by containing the extract of this as an active ingredient. From one or more plants selected from the group consisting of Nyctanthes albortristis, Piper chaba, Anthocephalus indicus and Crotalariacytisoides A collagenase inhibitor, characterized by comprising an extract of From one or more plants selected from the group consisting of Nyctanthes albortristis, Piper chaba, Anthocephalus indicus and Crotalariacytisoides The anti-aging agent characterized by containing the extract of this as an active ingredient. An anti-aging agent, wherein the extract has one or more actions selected from the group consisting of a collagen production promoting action, a hyaluronic acid production promoting action and a collagenase inhibiting action. From one or more plants selected from the group consisting of Nyctanthes albortristis, Piper chaba, Anthocephalus indicus and Crotalariacytisoides The food-drinks characterized by mix | blending this extract are disclosed.

Japanese Patent Laid-Open No. 2003-176232 (Patent Document 18) contains an extract from Himalayan cherry (Prunus cerasoides) as an active ingredient. An anti-aging agent characterized by containing an extract from Himalayan cherry (Prunus cerasoides) as an active ingredient. An anti-aging agent, wherein the extract has a collagenase inhibitory action. A food or drink characterized by blending an extract from Himalayan cherry (Prunus cerasoides) is disclosed.

Japanese Patent Application Laid-Open No. 2003-171307 (Patent Document 19) contains a solvent extract of Mannentake, which is a matrix metalloprotease inhibitor. A matrix metalloprotease inhibitor comprising a solvent extract of black reishi. A matrix metalloprotease inhibitor, wherein the extraction solvent is an extract of a solvent selected from one, two or more of water, lower alcohols, and liquid polyhydric alcohols. It contains a solvent extract of Mannentake to prevent, suppress, or improve symptoms of matrix metalloproteinase-promoted diseases related to cancer metastasis, ulceration, rheumatoid arthritis, osteoporosis, periodontitis and skin aging. The target pharmaceutical, quasi-drug, cosmetic or food is disclosed.

JP-A-2003-146838 (Patent Document 20) contains a collagenase inhibitor characterized by containing an extract from Machilus odoratissima and / or Potentilla fulgens as an active ingredient. . A hyaluronic acid production promoter comprising an extract from Machilus odoratissima and / or Potentilla fulgens as an active ingredient. An elastase inhibitor characterized by containing an extract from Machilus odoratissima and / or Potentilla fulgens as an active ingredient. An anti-aging agent comprising an extract from Machilus odoratissima and / or Potentilla fulgens as an active ingredient. The anti-aging agent, wherein the extract has one or more actions selected from the group consisting of collagenase inhibitory action, hyaluronic acid production promoting action and elastase inhibitory action. A cosmetic food and drink characterized by incorporating an extract from Machilus odoratissima and / or Potentilla fulgens is disclosed.

Japanese Patent Laid-Open No. 2003-146837 (Patent Document 21) contains a Kusunohagashi extract as an active ingredient, which is a collagen production promoter. A collagenase inhibitor comprising a Kusunohagashi extract as an active ingredient. A fibroblast proliferating agent comprising a Kusunohagashi extract as an active ingredient. Hyaluronic acid production promoter characterized by containing Kusunohagashi extract as an active ingredient. An elastase inhibitor comprising a Kusunohagashi extract as an active ingredient. An anti-aging agent comprising Kusunohagashi extract as an active ingredient. A cosmetic food or drink characterized by blending a Kusunohagashi extract is disclosed.

In JP-A-2003-137807 (Patent Document 22), the amino acid sequence is (Gly-Ala-X1), X1 is Ala, Arg, Asp, Hyp, Lys, Ser or Val, (Gly-Asp-X2). , X2 is Ala or Thr, (Gly-Gln-X3), X3 is Glu, Hyp or Ser, (Gly-Pro-X4), X4 is Ala, Arg, Hyp, Hyl, Gln, Met, Ile, Lys, Pro , Ser, Thr or Val, (Gly-Ser-X5), X5 is Ala, Glu or Hyp, (Gly-Lys-X6), X6 is Asp, Pro or Ser, (Gly-Leu-Hyp), or (Gly -Val- X7), X7 is a collagen production promoter characterized by comprising one or a mixture of two or more tripeptides represented by the general formula of Hyp or Arg as an active ingredient. The amino acid sequence is (Gly-Ala-Arg), (Gly-Ala-Hyp), (Gly-Ala-Lys), (Gly-Pro-Ala), (Gly-Pro-Arg), (Gly-Pro-Hyp) ) And a (Gly-Pro-Ser) tripeptide mixture represented by the general formula as an active ingredient. The amino acid sequence is (Gly-Ala-X1), X1 is Ala, Arg, Asp, Hyp, Lys, Ser or Val, (Gly-Asp-X2), X2 is Ala or Thr, (Gly-Gln-X3), X3 is Glu, Hyp or Ser, (Gly-Pro-X4), X4 is Ala, Arg, Hyp, Hyl, Gln, Met, Ile, Lys, Pro, Ser, Thr or Val, (Gly-Ser-X5), X5 is Ala, Glu or Hyp, (Gly-Lys-X6), X6 is Asp, Pro or Ser, (Gly-Leu-Hyp), or (Gly-Val-X7), X7 is a general formula of Hyp or Arg An anti-aging or wrinkle-suppressing agent characterized by comprising one or a mixture of two or more of the indicated tripeptides as an active ingredient is disclosed.

Japanese Patent Application Laid-Open No. 2003-128569 (Patent Document 23) contains an extract from a plant belonging to the genus Sauropus as an active ingredient. An antioxidant, wherein the extract has an active oxygen scavenging action and / or a radical scavenging action. An anti-aging agent comprising an extract from a plant belonging to the genus Sauropus as an active ingredient. An anti-aging agent, wherein the extract has one or more actions selected from the group consisting of collagen production promoting action, hyaluronic acid production promoting action and estrogen-like action.
A food or drink characterized by blending an extract from a plant belonging to the genus Sauropus is disclosed.

Japanese Patent Application Laid-Open No. 2003-128562 (Patent Document 24) contains an extract from a plant belonging to the genus Microcos as an active ingredient. An antioxidant, wherein the extract has an active oxygen scavenging action and / or a radical scavenging action. An anti-aging agent comprising an extract from a plant belonging to the genus Microcos as an active ingredient. An anti-aging agent, wherein the extract has one or more actions selected from the group consisting of collagen production promoting action, hyaluronic acid production promoting action and estrogen-like action.
A food or drink characterized by blending an extract from a plant belonging to the genus Microcos is disclosed.

Japanese Patent Application Laid-Open No. 2004-2237 (Patent Document 25) includes (phenylpropanoid, monoterpenoid, sesquiterpenoid, triterpenoid, coumarin, isocoumarin, chroman, chromene, taroquine, tannin and An anti-aging food or medicine for humans or animals comprising one or two or more herb ingredients selected from the group consisting of lignans and / or processed products thereof, wherein the herb ingredient is anethole, The anti-aging food or medicine for humans or animals according to claim 1, wherein the herbal ingredient is isoeugenol, characterized in that it is one or more selected from the group consisting of eugenol, camphene, geraniol, cineol and thymol. , Estragole, Carvacrol, Carvone Camphor, coumarin, glycyrrhizin, glycyrrhizin, curcumin, sapinene, salicylaldehyde, citronell, synamic aldehyde, cymene, gingiveren, tsuyoshi, terpineol, nerol, vanillin, ferrandolene, borneol, methylshavicol, menthol, menthone, linalool and limonene Anti-aging food or medicine for humans or animals selected from the group consisting of: a human or animal anti-aging food or medicine, wherein the concentration of the herb or / and processed product thereof in the food or medicine is 0.001-5 The anti-aging food or medicine for humans or animals according to any one of claims 1 to 3, characterized in that the herb is rice, oleander, perilla, ginger, celery, Peach eyes, legumes, citrus eyes, Anti-aging food or medicine for humans or animals, characterized in that it is one or more selected from the group consisting of Crenaceae and Lily eyes, herbs are Asaaceae, Gramineae, Asteraceae, Camphoraceae, Perilla The present invention is characterized in that it is one or two or more selected from the group consisting of a family of gynecologists, ginger departments, sericid departments, urchinaceae departments, myrtaceae departments, legumes, citrus departments, magnoliaceae departments, liliaceous departments and orchidaceae The anti-aging food or medicine for humans or animals according to any one of 1 to 8.

Herbs are asahi, anise, ajowan, allspice, oregano, cassia, camomile, garlic, cardamom, licorice, catnip, caraway, cumin, clove, poppy seed, pepper, sesame, coriander, saffron, savory, sunflower, Perilla, cinnamon, ginger, star anise, spearmint, sage, celery, thyme, dill, turmeric, tarragon, chili pepper, chilli, nutmeg, vanilla, basil, parsley, fenugreek, fennel, peppermint, horseradish, hop, marjoram, A human or one or two or more kinds selected from the group consisting of mustard, mace, eucalyptus, lavender, rice cake, lemon balm, rosemary, laurel and wasabi Anti-aging food or medicament for the object is disclosed.

JP-A No. 2003-119493 (Patent Document 26) discloses a blend containing a substituted organic acid, or a derivative thereof, and glyceride, wherein the blend is (i) 0.1 to 99.9% by weight. , Preferably 2 to 95% by weight of hydroquinone-substituted polyunsaturated fatty acid present in combo nut oil, in particular salgahydroquinoic acid (= SHQA) or an alcohol having 1 to 32 carbon atoms with said fatty acid Or derivatives thereof such as food acceptable salts thereof, (ii) 0 to 99.8% by weight, preferably 4 to 97% by weight of combo butter glycerides, and (iii) 0 A blend comprising from 1 to 99.9% by weight, preferably from 1 to 94% by weight of other triglycerides. Use of a composition comprising a hydroquinone-substituted polyunsaturated fatty acid or a derivative thereof as an active ingredient for the preparation of a food composition or food nutrition supplement having a health effect, comprising: The hydroquinone-substituted polyunsaturated fatty acid or derivative thereof present in the extract of (ii) has the following effects: (i) action as a lipase inhibitor, particularly as an inhibitor against pancreatic lipase, (ii) peroxisome proliferation Acting as a ligand for agent-activated receptor subtypes alpha or gamma, (iii) helping to reduce or prevent aging, particularly skin aging or skin light damage, (iv) the formation of decorin in the skin Promotion (v) acne reduction and / or prevention assistance, (vi) cellulite reduction and / or prevention assistance, (vii) body or mouth refreshment At least one of the following: (viii) preventing the formation of radicals and / or delaying the oxidation of fats and / or preventing or delaying the development of mammalian diseases associated with the presence of radicals Uses are disclosed that are used for the preparation of food compositions or food nutrition supplements.

JP-A-2003-95970 (Patent Document 27) contains an extract from Ficus simplicissima Lour. As an active ingredient. An anti-inflammatory agent, wherein the extract has a cyclic AMP phosphodiesterase inhibitory action.
Five finger hair peach (Ficus
An antioxidant comprising an extract from simplicissima Lour.) as an active ingredient. An antioxidant, wherein the extract has an active oxygen scavenging action and / or a radical scavenging action. An anti-aging agent characterized by containing an extract from Ficus simplicissima Lour. As an active ingredient is disclosed.

JP-A-2003-95913 (Patent Document 28) contains one or more protein degradation products selected from silk protein, keratin protein, and collagen protein. A skin anti-aging agent comprising one or more protein degradation products selected from silk protein, keratin protein, and collagen protein. A skin anti-aging agent comprising the following (1) and (2) as essential components: (1) One or more protein degradation products selected from silk protein, keratin protein, and collagen protein. (2) One or more kinds of plant extracts selected from enamel, hypericum, salvia, bodaiju and lakanka. Is disclosed.

JP-A-2003-55245 (Patent Document 29) contains an extract from a plant belonging to the genus Choerospondias as an active ingredient. An anti-inflammatory agent, wherein the extract has one or more actions selected from the group consisting of a hyaluronidase inhibitory action, a cyclic AMP phosphodiesterase inhibitory action and a histamine release inhibitory action. An antioxidant comprising an extract from a plant belonging to the genus Choerospondias as an active ingredient.
An antioxidant, wherein the extract has an active oxygen scavenging action and / or a radical scavenging action. An anti-aging agent comprising an extract from a plant belonging to the genus Choerospondias as an active ingredient.
An anti-aging agent, wherein the extract has one or more actions selected from the group consisting of collagen production promoting action, estrogen-like action, collagenase inhibitory action and elastase inhibitory action. A food or drink characterized by containing an extract from a plant belonging to the genus Choerospondias is disclosed.

JP-A-2003-55242 (Patent Document 30) contains an extract from a plant belonging to the genus Osbeckia as an active ingredient.
An anti-inflammatory agent, wherein the extract has one or more actions selected from the group consisting of a hyaluronidase inhibitory action, a cyclic AMP phosphodiesterase inhibitory action and a histamine release inhibitory action. An antioxidant comprising an extract from a plant belonging to the genus Osbeckia as an active ingredient. An antioxidant, wherein the extract has an active oxygen scavenging action and / or a radical scavenging action. An anti-aging agent comprising an extract from a plant belonging to the genus Osbeckia as an active ingredient. An anti-aging agent, wherein the extract has one or more actions selected from the group consisting of collagen production promoting action, collagenase inhibitory action and elastase inhibitory action. A food or drink characterized by blending an extract from a plant belonging to the genus Osbeckia is disclosed.

In JP 2003-12538 A (Patent Document 31), a solid medium containing mycelium obtained by inoculating shiitake fungus on a solid medium based on Bacus and then growing the mycelium is unbundled. Then, water and one or more enzymes selected from cellulase, glucosidase or protease are added to the unbound solid medium while keeping the solid medium at 30 to 50 ° C., and the solid medium is added to the enzyme. Extracted shiitake mycelium extract by crushing and crushing in the presence of water, then inactivating the enzyme by heating to a temperature up to 95 ° C. and sterilizing the anti-oxidant effect comprising shiitake mycelium extract Agent. An antioxidant agent for treating and / or preventing a disease involving oxidative cell damage caused by reactive oxygen species or lipid peroxide, comprising the above-mentioned shiitake mycelium extract and a pharmaceutically acceptable carrier as an optional component. The disease is selected from the group consisting of liver disorders caused by drugs and harmful substances, cardiovascular diseases, gastrointestinal diseases such as gastric ulcers and gastric mucosal disorders, respiratory diseases, diabetic complications, skin diseases, cancer, and aging An antioxidant agent according to claim 2 is disclosed.

Japanese Patent Application Laid-Open No. 2002-255784 (Patent Document 32) contains an extract of a rice bran with a polar solvent.
A composition for beautifying skin having an anti-aging effect on skin, comprising an extract of a rice bran polar solvent and comprising an extract comprising a polymer fraction having a molecular weight of about 30,000 to 40,000. A composition having a whitening / anti-aging effect, which is an extract of a rice bran polar solvent and contains an extract composed of a polymer fraction having a molecular weight of 5,000 or less, is disclosed.

Japanese Patent Application Laid-Open No. 2002-253288 (Patent Document 33) discloses a general formula (I):
In producing the phosphatide represented by R—O—PO (OH) —O—R ₁ (wherein R is a diacylglycerol residue and R ₁ is an alcohol residue), the general formula (II):
R—O—PO (OH) —O—R ₂ , wherein R is as described above, R ₂ is CH ₂ —CH ₂ —NH ₂ or CH ₂ —CH ₂ —N (CH ₃ ) ₃ . In the presence of phospholipase D having phosphatidyl transfer activity from Streptoverticillium hachijoense strain ATCC 19769 in a single aqueous phase. Reacting with a secondary alcohol. The alcohol residue has a C2 or C3 chain, the chain is bonded to an alcoholic hydroxyl group, and may optionally have one or more polar groups, A method in which a cyclic group may be formed with or without an additional carbon atom between a carbon atom and any atom of the polar group. A phosphatidyl-L-serine product having the same fatty acid composition as that of soy lecithin or egg lecithin and having a peroxide value of 5 or less. A medicinal product used to treat psychophysical stress, attention, concentration, or lack of memory associated with aging. Cosmetics comprising phosphatides of formula (I) are disclosed.
JP 2004-2237 A JP 2001-122765 A JP 2001-64253 A JP 2000-169382 A Japanese Patent Laid-Open No. 11-269082 JP 2004-131431 A JP 2004-129663 A JP 2004-91397 A JP 2004-83416 A JP 2004-10559 A JP 2003-342179 A JP 2003-306446 A Japanese Patent Laid-Open No. 2003-300893 JP 2003-252778 A JP 2003-252777 A JP 2003-238432 A JP 2003-183173 A JP 2003-176232 A JP 2003-171307 A JP 2003-146838 A JP 2003-146837 A Japanese Patent Laid-Open No. 2002-322077 JP 2003-128569 A JP 2003-128562 A JP 2004-2237 A JP 2003-119493 A JP 2003-95970 A JP 2003-95913 A JP 2003-55245 A Japanese Patent Laid-Open No. 2003-55242 JP 2003-12538 A JP 2002-255784 A JP 2002-253288 A

As described above, research on the prevention of aging, particularly the prevention of aging of the skin, has been progressing considerably, and compositions having various effects have been proposed. However, aging prevention involves various factors as described above, and it is difficult to find a decisive solution. The inventor focused attention on the synergistic effects of the active oxygen removal function, the collagen production promoting function, and the hyaluronic acid production promoting function.

  The present invention is intended to provide a composition having an anti-aging function, particularly an anti-aging function for skin, and a composition having a function containing the same, and the composition is used for cosmetics and foods and drinks. The subject is to provide.

A composition having an active oxygen removing function is examined. I was expecting the synergistic effect of wasabi and rush that I mentioned at the beginning.

About 220 species of rush (Juncus genus) are distributed throughout the world. It is cultivated mainly in Japan, China, and Southeast Asia because it is easy to grow in areas with relatively high humidity. The genus Juncus cultivated is used around the world as a rug and mop. In Japan, the plants of the genus Juncus are called “rush” and have been used for more than 60 years as a judo mat and indoor carpet. The rush has no history and has been used as a medicinal herb for diuretics and anti-inflammatory drugs since ancient times. In the clinical practice and application of Chinese medicine, it is said that 1.5 to 3 g should be taken once as a diuretic or as a treatment for edema. Furthermore, it is written that the new Japanese traditional Chinese medicine improves symptoms by applying a bite of rush to cuts, bleeding, and bruises. The rush has been shown to have antibacterial activity against enterohemorrhagic Escherichia coli O157. In addition, it had antibacterial activity against enterohemorrhagic Escherichia coli O26 and O111, Salmonella with the highest number of food poisoning, Staphylococcus aureus that caused problems due to milk contamination, and Bacillus subtilis and Micrococcus that were spoilage bacteria. . Antibacterial components are also resistant to acids and heat. For this reason, when rush is eaten, even if it passes through a stomach with a strong acidity, the antibacterial property is not lost, and it quickly reaches the intestines.

However, as “reactive oxygen” research has progressed in recent years, the “toxicity” of oxygen has become apparent. Oxygen literally oxidizes anything. Oxygen affects the iron rusting and the cut apples becoming black. Reactive oxygen has an oxidizing power approximately 1500 times that of oxygen and exerts an immune effect in small amounts, but when accumulated in the body in large quantities, cancer, arteriosclerosis, diabetes, aging, atopic dermatitis, allergic diseases It is known to cause various diseases. It is said that about 90% of diseases are caused by active oxygen. Active oxygen accumulates in the body by drinking alcohol and tobacco, accumulating stress, living in a dirty environment, and eating foods rich in food additives. However, these are unavoidable in modern life, and it is necessary to eat foods that eliminate active oxygen on a daily basis.

The rush is a plant excellent in scavenging active oxygen, and it has become clear that 4200 units of scavenging active oxygen per 1 g of rush. This value is about five times as high as kale, which is a raw material for green juice, which is also famous for eliminating active oxygen. Rabbits have as much as 63g of dietary fiber per 100g. This is quite high among various crops, about 40 times that of lettuce, about 9 times that of sweet potato, and about twice that of spinach. It has already been clarified that dietary fiber has many effects such as cholesterol suppression effect, blood sugar level increase suppression effect, colon cancer occurrence suppression effect.

Next, a composition having a function of promoting collagen production will be examined.

We focused on the extract of Kusunohagashi. The plant used as an active ingredient and extraction raw material is Kusunohagashi (scientific name: Mallotus philippinensis Mueller-Argoviensis, Chinese name: Luzon Shuumou) is an evergreen small Takagi belonging to Euphorbiaceae, Guangdong, Guangxi, Hunan, It is distributed in Yunnan, Sichuan, Zhejiang, Fujian, Jiangxi, Taiwan, etc. and is easily available from these areas. The constituent parts of the plant used as the extraction raw material are not particularly limited, and for example, constituent parts such as leaves, flower parts, root parts, bark, and branch parts can be used as the extraction raw material. Among these, it is particularly preferable to use bark as an extraction raw material.

Extracts having these actions can be obtained from Kusnohagashi by an extraction method generally used for the extraction of plants. For example, it can be obtained by drying the raw material for extraction and pulverizing it as it is or using a crusher and subjecting it to extraction with an extraction solvent. At this time, the extraction raw material may be dried in the sun or using a commonly used dryer. Further, Kusunohagashi may be used as an extraction raw material after pretreatment such as degreasing with a nonpolar solvent such as hexane or benzene. By performing pretreatment such as degreasing, extraction with a polar solvent can be performed efficiently. As the extraction solvent, it is preferable to use water, a hydrophilic organic solvent, or a mixture thereof at room temperature or a temperature not higher than the boiling point of the solvent. Examples of water that can be used as the extraction solvent include pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, fresh water, and the like, as well as water that has been subjected to various treatments.

Examples of the treatment applied to water include purification, heating, sterilization, filtration, ion exchange, adjustment of osmotic pressure, buffering, and the like. Therefore, the water that can be used as the extraction solvent in the present invention includes purified water, hot water, ion-exchanged water, physiological saline, phosphate buffer, phosphate buffered saline, and the like. Examples of the hydrophilic organic solvent that can be used as the extraction solvent include lower alcohols having 1 to 5 carbon atoms such as methanol, ethanol, propyl alcohol, and isopropyl alcohol; lower aliphatic ketones such as acetone and methyl ethyl ketone; 1,3-butylene. Examples thereof include polyhydric alcohols having 2 to 5 carbon atoms such as glycol, propylene glycol and glycerin. When using the liquid mixture of 2 or more types of polar solvents as an extraction solvent, the mixing ratio can be adjusted suitably. For example, when using the liquid mixture of water and a lower aliphatic alcohol, the mixing ratio of water and a lower aliphatic alcohol can be 7: 3 to 2: 8 (weight ratio).

The extraction treatment is not particularly limited as long as the soluble component contained in Kusunohagashi can be eluted in the extraction solvent, and can be performed according to a conventional method. In the extraction process, it is not necessary to adopt a special extraction method, and any apparatus can be used at room temperature or under reflux heating. Specifically, the raw material for extraction is put into a treatment tank filled with the extraction solvent, and is usually left standing for 1 to 3 hours with occasional stirring to elute soluble components, followed by filtration to remove solid matter. An extract is obtained by removing and evaporating the extraction solvent from the resulting extract and drying. The amount of the extraction solvent is usually 5 to 15 times the weight of the extraction raw material (weight ratio), and the extraction temperature is usually from room temperature to 95 ° C. The obtained extract is diluted, concentrated, dried, purified, etc. according to a conventional method in order to obtain a diluted or concentrated solution of the extract, a dried product of the extract, or a crude purified product or a purified product thereof. Processing may be performed. The obtained extract can be used as it is, but a concentrated solution or a dried product is easier to use.

Formulation of an extract from Kusunohagashi can be performed according to a conventional method. For formulation, in order to facilitate storage and handling, pharmaceutically acceptable carriers such as dextrin and cyclodextrin and other auxiliary agents can be added. It can be formulated into any dosage form such as granular or tablet. Since Kusunohagashi extract has a unique odor, it can be purified for the purpose of decolorization, deodorization, etc. within the range that does not cause a decrease in its physiological activity. Since it is not used in a large amount when added to, etc., there is no practical problem even if it is not purified. Specifically, purification can be performed by activated carbon treatment, adsorption resin treatment, ion exchange resin treatment, or the like. In this agent, the collagen production promoter can prevent and / or improve skin aging by activating collagen production by fibroblasts and supplying sufficient collagen to the dermis layer.

Next, a composition having a hyaluronic acid accumulation promoting function will be examined.

Aloe vera, Lamorka (Momordicagrosvenorii), Eucommia ulmoides, Maca (Lepidiummee yenii), Oats (Avena sativa), Hercules (Gentianella alborocea), Calcades (Hibiscus sabdariffa), Dill (Anethum grave) Calendula officinalis), Ryugannik (Euphoria longana), Fennel (Foeniculum vulgare), Cha (Thea sinensis), Penny Royal Mint (Mentha pulegium), Nettle (Urtrica thunbergiana), Areca catechu, Tartary buckwheat (Fagopyrumtya (Fagopyrumtya) We focused on extracts from plants selected from Uncaria gambir), Terminalia arjuna.

The plant can be used for all parts such as leaves, stems, buds, flowers, woody parts, bark parts (bark) and the like, and underground parts such as roots and tubers, seeds, fruits and resins. In addition, the plant is a dried product obtained by drying the plant itself, a pulverized product thereof, a juice obtained by squeezing and extracting the product itself, a crude extract with water or an organic solvent such as alcohol, ether or acetone, This includes all of the extract fractions obtained by stepwise purification of the product by liquid-liquid distribution, column chromatography, and the like. These may be used alone or in combination of two or more.

For example, an extract obtained by adding 3 L of ethanol to 1 kg of a dry plant of Ryugannik and immersing it overnight at room temperature is a composition for improving skin wrinkles and a composition for moisturizing skin that has an action of promoting hyaluronic acid accumulation. It is used as a composition for preventing skin aging, a composition for inhibiting thrombus formation, a composition for treating arthritis, a composition for treating rheumatism, a composition for preventing dry eye, a composition for softening blood vessels, and a composition for treating arteriosclerosis. Alternatively, a purified product obtained by combining liquid-liquid distribution and various types of chromatography may be used.

Hyaluronic acid is known as a biological component that exhibits extremely high water retention ability and viscoelasticity. It can be said that hyaluronic acid hardly exists alone in the living body, and a hyaluronic acid-binding molecule such as a protein having various hyaluronic acid-binding activities binds to form a unique matrix. This hyaluronic acid-rich matrix is found in most sites where active metabolic changes and cell proliferation are observed.

Hyaluronic acid can be used to prevent dry skin and keep fresh skin due to its excellent water retention ability. The skin is a tissue rich in hyaluronic acid, but hyaluronic acid is reduced in molecular weight with aging, and its water retention ability decreases. Therefore, aging of the skin can be prevented by maintaining abundant hyaluronic acid in the skin. By promoting the production amount of hyaluronic acid, it is possible to improve a disorder or pathology that occurs in a tissue such as a blood vessel, a joint, or an eyeball caused by a decrease in the production amount of hyaluronic acid. It can also inhibit thrombus formation by promoting the production of hyaluronic acid, which has an inhibitory effect on thrombus formation.

The effective dose of the plant as an active ingredient is appropriately selected and determined according to the patient's age, weight, symptom, patient grade, administration route, administration schedule, formulation form, strength of inhibitory activity of the material, etc. In the case of oral administration, it is generally about 0.001 to 1000 mg / kg per day, and in the case of Aloe vera ethanol extract, it is about 10 to 200 mg / kg per day, and may be divided into several times a day.

Further, when the agent of the present invention is contained and used as a hyaluronic acid accumulation promoter-containing cosmetic or cosmetic material, for example, a dried oat or extract is added to wheat germ oil or olive oil. Can be used as

Moreover, the cosmetics which use the said hyaluronic acid accumulation promoter as a cosmetic ingredient directly can be manufactured. The cosmetic product containing the hyaluronic acid accumulation promoter obtained by the method of the present invention is not particularly limited, but from the functional aspect, for example, emulsion, cosmetic solution, face cream, hand cream, lotion, essence, shampoo. Rinse and the like are preferable. Such cosmetics can be manufactured according to a conventional method.

The amount of the dried plant product or extract, which is an active ingredient in cosmetics, is not particularly limited. For example, an appropriate amount is about 0.01% to 20% by weight of the total weight of the cosmetic. . The plant, which is an active ingredient, has low toxicity because it is a natural product.For example, even if an ethanol extract of fennel is orally administered to rats for a long period of 1000 mg / kg daily for 100 days, death cases are observed. Neither weight change was observed.

This inventor provides the composition for anti-aging which made the following structure a requirement, and the cosmetics and food-drinks containing it. That is,
(1) Wasabi extract and rush extract as essential ingredients,
(2) Add the extract of Kusunohagashi,
(3) Preferably, Aloe vera (Aloe vera), Lacanka (Momordicagrosvenorii), Eucommia ulmoides, Maca (Lepidiummee yenii), Oats (Avena sativa), Hercules (Gentianella alborocea), Calcade (Hibiscus sabdariffa), (Anethum graveolens), calendula officinalis, longanic (Euphoria longana), fennel (Foeniculum vulgare), tea (Thea sinensis), penny royal mint (Mentha pulegium), nettle (Urtrica thunbergiana), betel catechu (Areca) An anti-aging agent and a cosmetic and food and drink containing the same, comprising a composition comprising an extract from a plant selected from Tartary buckwheat (Fagopyrumtartaricum), Uncaria gambir and Terminalia arjuna Provide goods.

ADVANTAGE OF THE INVENTION According to this invention, the composition which prevents aging, and the cosmetics and food-drinks containing it can be provided from the surface of a skin and the surface in a body about aging prevention.

(1) Wasabi extract and rush extract as essential components, (2) Further, an extract of Kusunohagashi is added, (3) Preferably, Aloe vera (Aloe vera), Lakanka (Momordicagrosvenorii), Eucommia ulmoides ), Maca (Lepidiummee yenii), Oats (Avena sativa), Herbal Brix (Gentianella alborocea), Kalkade (Hibiscus sabdariffa), Dill (Anethum graveolens), Calendula officinalis, Ryugannik (Euphoriagaranae), Fennel (Euphoriagaranae) ), Cha (Thea sinensis), Penny Royal mint (Mentha pulegium), Nettle (Urtrica thunbergiana), Areca catechu, Tartary buckwheat (Fagopyrumtartaricum), Asenayaku (Uncaria gambir), Cyclicaceae terminia arjuna (Terminalia arjuna) A composition comprising an extract from a selected plant is obtained, and this is used as a composition. That, anti-aging agents and cosmetics 及飲 foods containing it.

  EXAMPLES The present invention will be described more specifically with reference to examples. However, the present invention is not limited to the examples.

[Preparation of rush extract]
Put 100g of dried and crushed raw material in 10 times amount of hot water at 60 ° C, extract for one day and night, centrifuge and separate into extract and residue. Add about 5 times the amount of hot water at 100 ° C again. The mixture was extracted at 60 ° C. and extracted at 100 ° C., and the mixture was extracted into an rush extract. After filtering this extract at about 50 ° C., After cooling to 15 ° C. again, filtration was performed, followed by concentration under reduced pressure, further freeze-drying, and a solution dissolved in 10 ml of distilled water was prepared as an extract.

[Preparation of Wasabi Extract]
100 g of dried and crushed raw material (root part: leaf part = 1: 1) is placed in 10 times the amount of hot water at 60 ° C., extracted for one day and night, and after centrifugation, separated into an extract and a residue. Double the amount of hot water at 100 ° C and extract for one day, centrifuge, and mix the extract extracted at 60 ° C and the extract extracted at 100 ° C to make wasabi extract. After filtration at about 50 ° C., the solution was cooled again to 15 ° C., then filtered, concentrated under reduced pressure, further lyophilized, and then dissolved in 10 ml of distilled water as an extract. did.

[Preparation of Kusunohagashi extract]
Put 100g of dried and crushed raw material in 10 times amount of hot water at 60 ° C, extract for one day and night, centrifuge and separate into extract and residue. Add about 5 times the amount of hot water at 100 ° C again. The mixture was extracted one day and night, centrifuged, extracted at 60 ° C. and extracted at 100 ° C. to obtain a Kusunohagashi extract, and this extract was filtered at about 50 ° C. After cooling to 15 ° C. again, filtration was performed, followed by concentration under reduced pressure, further lyophilization, and then a solution dissolved in 10 ml of distilled water was prepared as an extract.

[Preparation of extracts from plants, aloe vera, etc.]
Aloe vera, lacanca, eucommia, maca, oat, elcumburi, calcade, dill, eucalyptus, ryugannik, fennel, tea, penny royal mint, nettle, betel loj, tartary buckwheat, asenyaku, cicariaceae terminalia arjuna, 10 times the amount In 60 ° C. hot water, extracted for one day and night, and after centrifugation, separated into the extract and the residue. The residue was again extracted by adding about 5 times the amount of 100 ° C. hot water for one day and night and centrifuged. After that, a mixture of the extract extracted at 60 ° C. and the extract extracted at 100 ° C. was used as each of the above plant extracts, and the extract was filtered at about 50 ° C. and then cooled to 15 ° C. again. Thereafter, filtration was performed, followed by concentration under reduced pressure, further freeze-drying, and then a solution dissolved in 10 ml of distilled water was prepared as an extract. In this example, maca extract was used.

Preparation of cosmetics. The following cosmetics were prepared.

The skin lotion is heated and dissolved while maintaining at 80 ° C., together with the functional components for preventing aging, with 100% by weight of the following as common components, and cooled while stirring to 40 ° C. Then, it prepared by stirring and melt | dissolving uniformly.
a) Glycerol 5.0
b) Polyoxyethylene sorbitan monolaurate (20E.O.) 1.0
c) Ethanol 6.0
d) Perfume appropriate amount e) Vitamin C 0.05
f) Purified water residue

Formulated with functional components to prevent aging.
Lotion A
1. Wasabi extract and rush extract (1: 1) 6.0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Lotion B
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 6.0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Lotion C
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 0
3. Extract of rush 6.0
4). Kusunohagashi extract 0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Lotion D
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 6.0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Lotion E
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca extract 6.0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Lotion F
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 6.0

Lotion G
1. Wasabi extract and rush extract (1: 1) 3.0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 3.0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Lotion H
1. Wasabi extract and rush extract (1: 1) 3.0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca Extract 3.0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Lotion I
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi Extract 3.0
3. Rush extract 0
4). Kusunohagashi extract 3.0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Lotion J
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi Extract 3.0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca Extract 3.0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Lotion K
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Regarding the cosmetics prepared by the above formulation, the effect on the reduction of wrinkles and spots on the skin was examined by actual use. Rub the face of 10 women (age 40 to 50 years) who feel wrinkles and wrinkles on the face twice a day (every morning and every night) for 3 months. The results shown in Table 1 were obtained by their own evaluations. As is clear from Table 1, this anti-aging cosmetic material also showed an excellent effect for preventing skin aging. Also, no undesired symptoms occurred.

These results are based on the result determination of the determination method. In the criteria for the anti-aging test, x means that no improvement is observed despite use.
○ means that the progress of wrinkles and spots is reduced.
◎ means that wrinkles and spots have stopped progressing.

Table 1
Panel ab c de f gh i j
Lotion A ◎ ○ ◎ ○ ◎ ◎ ○ ◎ ◎ ◎
Lotion B ○ ○ ◎ ○ ○ ◎ ○ ○ ◎ ○
Lotion C ○ ○ ○ ◎ ○ ○ ◎ ○ ○ ○
Lotion D ○ ◎ ○ ○ ◎ ○ ○ ◎ ○ ○
Lotion E ◎ ○ ○ ○ ○ ◎ ○ ◎ ○ ○
Lotion F ◎ ◎ ○ ◎ ◎ ◎ ◎ ◎ ◎ ◎

Lotion G ◎ ○ ◎ ◎ ◎ ○ ○ ◎ ○ ◎
Lotion H ◎ ○ ◎ ○ ◎ ◎ ○ ○ ◎ ○
Lotion I ○ ◎ ○ ◎ ○ ○ ◎ ◎ ○ ○
Lotion J ○ ◎ ○ ◎ ○ ○ ○ ◎ ○ ◎
Lotion K No No No No No No No No No No No

From Table 1, a composition comprising (1) horseradish extract and rush extract as essential ingredients, (2) further adding an extract of Kusunohagashi, and (3) an extract of maca (Lepidiummee yenii) As a result, a remarkable anti-aging effect was recognized in the prepared cosmetics.

An anti-aging beverage was prepared as follows.

Beverages were prepared together with functional components for preventing aging, with the following as common components out of 100 parts by weight as a whole.
A. Lemon juice 3.0
B. Vitamin C 0.02
C. Purified water residue

Formulated with functional components to prevent aging.
Beverage A
1. Wasabi extract and rush extract (1: 1) 6.0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Beverage B
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 6.0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Beverage C
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 0
3. Extract of rush 6.0
4). Kusunohagashi extract 0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Beverage D
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 6.0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Beverage E
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca extract 6.0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Beverage F
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 6.0

Beverage G
1. Wasabi extract and rush extract (1: 1) 3.0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 3.0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Beverage H
1. Wasabi extract and rush extract (1: 1) 3.0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca Extract 3.0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Beverage I
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi Extract 3.0
3. Rush extract 0
4). Kusunohagashi extract 3.0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Beverage J
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi Extract 3.0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca Extract 3.0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

Beverage K
1. Wasabi extract and rush extract (1: 1) 0
2. Wasabi extract 0
3. Rush extract 0
4). Kusunohagashi extract 0
5. Maca extract 0
6). Wasabi, rush, Kusunohagashi, maca extract (1: 1: 1: 1) 0

About the drink prepared by the said prescription, the effect about the physical condition by examination was examined. Recently, 10 women (aged 40 to 50 years old) who feel symptom of a little stress due to the age have taken 10ml twice a day (every morning, every night) for one month, The results shown in Table 2 were obtained by their own evaluations. As is clear from the table, this anti-aging cosmetic has an excellent effect on maintaining and improving physical condition. Also, no undesired symptoms occurred.

These results are based on the result determination of the determination method. In the criteria for the anti-aging test, x means that no improvement is seen despite drinking.
○ means that he feels much better.
◎ means that you feel that your physical condition has improved significantly.

Table 2
Panel ab c de f gh i j
Beverage A ◎ ○ ◎ ◎ ◎ ◎ ○ ◎ ◎ ○
Beverage B ○ ◎ ○ ○ ○ ◎ ○ ○ ◎ ○
Beverage C ○ ○ ◎ ◎ ○ ○ ○ ○ ◎ ○ ○
Beverage D ○ ○ ◎ ○ ◎ ○ ○ ◎ ○ ○
Beverage E ◎ ○ ○ ○ ◎ ◎ ○ ○ ○ ◎
Beverage F ○ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎

Beverage G ○ ◎ ○ ◎ ◎ ◎ ○ ◎ ○ ◎
Beverage H ◎ ○ ◎ ○ ○ ◎ ◎ ○ ◎ ○
Beverage I ◎ ○ ○ ◎ ○ ○ ◎ ◎ ○ ○
Beverage J ○ ○ ◎ ◎ ○ ◎ ○ ◎ ○ ○
Beverage K × × × × × × × × × ×

From Table 2, a composition comprising (1) horseradish extract and rush extract as essential components, (2) further adding an extract of Kusunohagashi, and (3) further adding an extract of maca (Lepidiummee yenii) Ingestion of beverages prepared from these extracts showed a significant improvement in physical condition, suggesting an effect of preventing aging.

Claims (4)

An anti-aging composition comprising a wasabi extract and a rush extract as essential components. A composition for preventing aging, characterized by comprising, as an essential component, a wasabi extract and a rush extract further added with an extract of Kusunohagashi.   Wasabi extract and rush extract , Karcade (Hibiscus sabdariffa), dill (Anethum graveolens), calendula officinalis, longanian (Euphoria longana), fennel (Foeniculum vulgare), tea (Thea sinensis), penny royal mint (Mentha pulegr), ne thunbergiana), areca catechu, tartary buckwheat (Fagopyrumtartaricum), Acacia yam (Uncaria gambir), characterized by comprising an extract from a plant selected from the plant family Terminalia arjuna (Terminalia arjuna), Anti-aging composition. Cosmetics and food / beverage products characterized by containing the composition for anti-aging of Claims 1-3.