JP2006045080A - Skin care preparation suitable as quasi-drug - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To stabilize a melanin production suppressing substance under a high-temperature condition and to provide a skin care preparation containing a melanin production suppressing substance having improved storage stability under a high-temperature condition. <P>SOLUTION: The skin care preparation contains (1) one or more substances selected from ascorbic acid, its derivative, arbutin, tranexamic acid, 4-methoxysalicylic acid and their salts and (2) one or more substances selected from quaternium compounds. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable for cosmetics such as quasi drugs.

For skin preparations such as cosmetics, it is one of the important requirements to prevent excessive production of melanin pigment and keep the skin white. For this reason, various substances that suppress melanin production (hereinafter also referred to as “melanin production inhibitors”) have been searched and obtained. Examples of such substances include 1) glutathione derivatives, 2) ascorbic acid and its derivatives (including phosphate esters of ascorbic acid and glycosides of ascorbic acid such as ascorbic acid glucoside), 3) sulfur atoms 4) Hydroquinone and arbutin, and their glycosides, 4) tranexamic acid, 5) 4-methoxysalicylic acid, 6) kojic acid and the like can be preferably exemplified.
Among these, ascorbic acid and its derivatives, arbutin, tranexamic acid, 4-methoxysalicylic acid, and salts thereof are particularly promising from the viewpoint of melanin production inhibitory effect and safety (for example, non-patented) Reference 1). However, many of these melanin production inhibitors are substances having reducibility, and there has been a problem in stability under high temperature conditions. Therefore, it has been desired to develop a means for improving the stability of the melanin production inhibitor contained in the external preparation for skin under high temperature conditions.

  Several means are known for stabilizing reducing substances such as melanin production inhibitors. For example, as a means for improving the light stability of the substance, a method of combining an ultraviolet absorber such as benzophenones and cinnamic acid esters can be mentioned (for example, see Patent Document 1). However, such means is not sufficient as means for improving the stability of the reducing substance under high temperature conditions.

  On the other hand, it is known that quaternium has an effect of enhancing water retention of hair or the like or an effect of uniformly showing unevenness of the three-dimensional shape of the skin (see, for example, Patent Documents 2 to 3).

However, a skin external preparation containing both the melanin production inhibitor and quaternium is not known, and the effect of the skin external preparation is not known.
Japanese Patent Application Laid-Open No. 06-48935 JP 2004-35556 A Special table 2001-522786 gazette Supervised by Katsuyuki Takeda et al. "Advances in cosmetics evaluation technology and future prospects" published by Yakuji Nippo (2001)

The present invention has been made under such circumstances, and is a substance that suppresses melanin production (for example, ascorbic acid and its derivatives (including ascorbic acid phosphate ester, ascorbic acid-2-glucoside, etc.), arbutin, tranexamic acid. , 4-methoxysalicylic acid, and salts thereof, etc.) and a means for improving the stability under high temperature conditions.
Another object of the present invention is to provide an external preparation for skin having a storage stability under a high temperature condition and having a melanin production inhibitory effect by using the means.

In view of such a situation, the present inventors have used various skin melanin production inhibitors (including ascorbic acid and its derivatives, arbutin, tranexamic acid, 4-methoxysalicylic acid, and salts thereof). In search of means for further improving the storage stability of the agent under high temperature conditions, intensive research efforts were made. As a result, it was found that the storage stability of the melanin production inhibitor contained in the external preparation for skin was improved by quaternium.
From this finding, it was found that when the skin external preparation containing a melanin production-suppressing substance further contains quaternium, the skin external preparation can be stably stored even under high temperature conditions, and the present invention has been completed. . That is, this invention relates to the technique shown below.

(1) 1) One or more selected from ascorbic acid and derivatives thereof, arbutin, tranexamic acid, 4-methoxysalicylic acid, and salts thereof, and 2) one or more selected from quaternium A skin external preparation characterized by containing.
(2) The external preparation for skin according to (1), wherein the derivative of ascorbic acid is ascorbic acid phosphate ester or ascorbic acid-2-glucoside.
(3) The content of one or more selected from the ascorbic acid and its derivatives, arbutin, tranexamic acid, 4-methoxysalicylic acid and salts thereof is 0.1 to The external preparation for skin according to (1) or (2), wherein the external preparation is 10% by mass.
(4) Content of 1 type (s) or 2 or more types selected from said quaternium is 0.01-5 mass% with respect to the skin external preparation whole quantity, (1)-(3) characterized by the above-mentioned. The external preparation for skin according to any one of the above.
(5) The skin external preparation according to any one of (1) to (4), which is a cosmetic.
(6) The external preparation for skin according to any one of (1) to (5), which is a quasi-drug for suppressing melanin production.
(7) The skin external preparation according to any one of (1) to (6), characterized by appealing an inhibitory action on melanin production.

  ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation with high storage stability in high temperature conditions can be provided.

(1) Melanin production inhibitor which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing a melanin production inhibitor as an essential ingredient. Examples of the melanin production inhibitor include one or more selected from ascorbic acid and derivatives thereof, arbutin, tranexamic acid, 4-methoxysalicylic acid, and salts thereof. All of these components are known as components that can be contained in cosmetics (particularly, quasi-drug cosmetics). Therefore, there is no problem regarding the acquisition of these, and commercially available raw materials can be purchased and used.

  Among the substances that suppress melanin production, ascorbic acid is a compound having a structure represented by the following formula (I). Preferred examples of the derivatives of ascorbic acid include fatty acid esters of ascorbic acid, phosphate esters of ascorbic acid, glycosides of ascorbic acid, and the like. More preferable examples include phosphate esters of ascorbic acid and glycosides of ascorbic acid.

  The fatty acid ester of ascorbic acid is obtained by fatty acid esterification of any of hydroxyl groups A to D in the above formula (I), and preferably the hydroxyl group of A and / or D is fatty acid esterified. Is. Examples of the fatty acid of the fatty acid ester include, but are not limited to, palmitic acid.

  As the phosphoric acid ester of ascorbic acid, the hydroxyl group of any one of A to D in the above formula (I) is phosphorylated, but preferably the hydroxyl group of A or B is phosphorylated. Particularly preferred is ascorbyl 2-phosphate ester in which the hydroxyl group of A is phosphorylated.

  The glycoside of ascorbic acid is a glycoside of ascorbic acid and a normal naturally occurring sugar, and is not particularly limited. For example, glucoside, arabinoside, riboside, deoxyriboside, galactoside, rhamnoside, arabinosyl glucoside, glucosyl galactoside, rhamnosyl glucoside and the like can be preferably exemplified. Further, a glycoside in which the hydroxyl oxygen atom of A in the above formula (I) and the C-1 carbon atom of the sugar are ether-bonded is preferable. For example, ascorbic acid-2-glucoside is particularly preferably exemplified.

The glycoside of ascorbic acid can be produced according to a conventional method, or a commercially available product can be purchased and used. As a production method, for example, a saccharide, an enzyme using it as a substrate, and ascorbic acid may be allowed to coexist and incubated at 30 to 50 ° C. For example, in the case of glucoside, ascorbic acid, glucose and glucosidase are incubated, and thereafter, silica gel column chromatography, partition chromatography using an ion exchange resin such as “Diaion HP-20” (manufactured by Mitsubishi Kasei Co., Ltd.). , Gel filtration column chromatography, column chromatography using ODS as a filler, and the like.
On the other hand, as a commercial item, ascorbic acid-2-glucoside currently sold from Hayashibara Laboratory Co., Ltd. can be illustrated preferably.

  The melanin production inhibitor contained in the external preparation for skin of the present invention may be contained in a free form or as a salt. Examples of the salt include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt and magnesium salt, organic amine salts such as ammonium salt, triethylamine salt, triethanolamine salt and morpholine salt, Preferred examples include basic amino acid salts such as lysine salts and arginine salts. These salts can be obtained by reacting a melanin production inhibitor with a corresponding base.

Melanin production inhibitor (including ascorbic acid and its derivatives, arbutin, tranexamic acid, 4-methoxysalicylic acid, or salts thereof) can be contained alone in the skin external preparation of the present invention, Two or more kinds may be contained in combination. The content of the melanin production inhibitor in the external preparation for skin of the present invention is preferably 0.1 to 10% by mass, and preferably 0.5 to 5% by mass, based on the total amount of external preparation for skin. Is more preferable. When the content is 0.1% by mass or more, the melanin production inhibitory effect is sufficiently exhibited, and when the content is 10% by mass or less, it is preferable in terms of cost.

(2) Quotanium as an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing one or more kinds selected from quaternium as an essential component. Here, quaternium means a compound having a quaternary amino group, which is recognized as a cosmetic ingredient by the American Cosmetic Industry Association (CTFA), classified as quaternium, and numbered. Among these, it can select without special limitation.

Examples of quaternium include quaternium 14 (lauryldimethylethylbenzylammonium chloride; McCourt MQ2525M; manufactured by Masson), quaternium 15 (N- (3-chloroallyl) hexanium chloride; Dauisil 200; manufactured by Dow Corning), and quaternium 18 ( Dimethyldi (hydrogenated tallow) ammonium chloride; Varisoft 442 100P; manufactured by Degassa Specialty), quaternium 22 (γ-gluconamidopropyl dimethyl 2-hydroxyethylammonium chloride; Cerafil 60; manufactured by International Specialties), quaternium 24 (Decyldimethyloctylammonium chloride; McCoat 4050; manufactured by Masson), quaternium 26 (mincamidepropyldimethyl 2-hydroxy) Cyethylammonium chloride; Incrocoat 26; manufactured by Kuroda), Quotanium 27 (4,5-dihydro-1-methyl-2-nortaroualkyl-1- (2-tallowamidoethyl) imidazolium methyl sulfate; AEC quaternium 27; A & E Connock), Quotanium 33 (N (N 'lanolin fatty acid amidopropyl) N-ethyl-N, N-dimethylammonium ethyl sulfate; Nikkor Lanocoat DES-50; manufactured by Nikko Chemicals Co., Ltd.), Quotanium 43 (Cocamid) Propyldimethylacetamide ammonium chloride; Simexan CK: manufactured by Simex Corporation), quaternium 45 (LUMEX; manufactured by Ikeda Bussan Co., Ltd.), quaternium 52 (POE (octadecylnitrilorio) tri-2,1-ethanediyl) Lithoxyphosphate; Dehicoat SP; manufactured by Cognis Co., Ltd.), Quotanium 53 (Incrosoft T-90; manufactured by Kuroda Co., Ltd.), Quaternium 60 (lanolin, isostearamidopropylethyldimethylammonium etosulphate; Lanocoat 1751A, manufactured by Cognis Co., Ltd.), quaternium 61 (dimer acid bis (amidopropyl-N, N-dimethyl-N-ethylammonium ethosulphate; shell coat DAS; manufactured by Shell), quaternium 70 (stearamidopropyldimethyl (myristyl acetate) ammonium chloride; cerafil 70: International Specialty Co., Ltd.), Quotanium 72 (Incrosoft CFI75; Kuroda Corp.), Quotanium 73 (Photosensitive Element 201; Photosensitive Element Co., Ltd.), Kuotaniu 75 (Levenol conditioner C727; made by Levenstein), quaternium 76 collagen complex (Lexaine QX-3000; made by Inorex), quaternium 77 (Finsoft HCM-100; made by Finetex), quaternium 79 (Mac Pro) NLP; manufactured by McKintile, Inc., quaternium 80 (Covafix 123; manufactured by LCW), quaternium 82 (stepan coat DC1; manufactured by Stepan), quaternium 84 (mackernium NLE; manufactured by McKintile), quaternium 85 (2- Hydroxy-3-((2-hydroxyethyl) (2-((1-oxotetradecyl (amino) ethyl) amino) -N, N, N-trimethyl-1-propaneaminium chloride; amino cation S-36; Kao stock Quotanium 86 (Pecosil SWQ-40; manufactured by Phoenix), Quaterium 87 (Varisoft W575PG; manufactured by Degassa), Quaterium 88 (Necoat DAS-D; manufactured by Arzo), Quotanium 89 (Fincoat CT-P) Preferably made by Finetech), and quaternium 91 (Kurodasoft DBQ; made by Kuroda).
Of these, more preferred are quaternium 33, quaternium 45, quaternium 73, quaternium 80 and quaternium 85.

  Since quaternium is already marketed as a cosmetic raw material, such a commercial product can be purchased and used. These are all commonly used components and are readily available. The skin external preparation of this invention can also contain only 1 type of this component, and can also contain it in combination of 2 or more types. The content of such components in the external preparation for skin of the present invention is a total amount, preferably 0.01 to 5% by mass, more preferably 0.05 to 3% by mass with respect to the total amount of external preparation for skin. preferable. If the content of such a component is too small, it may be difficult to sufficiently improve the storage stability of the melanin production inhibitor (which may be a reducing whitening component). This is because the feeling of use may be impaired.

(3) The external preparation for skin of the present invention The external preparation for skin of the present invention comprises:
1) Ascorbic acid and its derivatives, arbutin, tranexamic acid, 4-methoxysalicylic acid, and one or more thereof selected from salts thereof (melanin production inhibitor), and 2) one or more selected from quaternium Although it is characterized by containing 2 or more types, in addition to these essential components, it can contain the arbitrary components normally used with a skin external preparation.

  Examples of such components include oils / waxes, hydrocarbons, higher fatty acids, higher alcohols, synthetic ester oils, oil agents, surfactants, polyhydric alcohols, moisturizing ingredients, thickeners, Examples thereof include powders, inorganic pigments, pearl agents, organic dyes, organic powders, ultraviolet absorbers, lower alcohols, vitamins, and polymers having a biologically similar structure.

Examples of oils and waxes include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hardened coconut oil, hardened Oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, etc.
Examples of hydrocarbons include liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, and microcrystalline wax.
Examples of higher fatty acids include oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid,
Examples of higher alcohols include cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol,
Synthetic ester oils include, for example, cetyl isooctanoate, isopropyl myristate, hexyl decyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diisostearyl malate, ethylene di-2-ethylhexanoate Glycol, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, tetra-2-ethylhexane Acid pentane erythritol, etc.
Examples of oils include chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and diphenylpolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane, and amino-modified polysiloxanes. Preferred examples include silicone oils such as modified polysiloxanes such as siloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, and fluorine-modified polysiloxane.

As the surfactants, for example, any of anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants may be used.
Examples of the anionic surfactants include fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, alkyl sulfate triethanolamine ether, etc.
Examples of cationic surfactants include stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide,
Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaines, amide betaines). , Sulfobetaine, etc.), acylmethyl taurine, etc.
Nonionic surfactants include, for example, sorbitan fatty acid esters (such as sorbitan monostearate and sorbitan sesquioleate), glycerin fatty acids (such as glyceryl monostearate), and propylene glycol fatty acid esters (such as propylene glycol monostearate). ), Hardened castor oil derivative, glycerin alkyl ether, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin Fatty acid esters (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl Ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose fatty acid ester, alkyl glucoside and the like can be preferably exemplified.

Examples of polyhydric alcohols include polyethylene glycol, glycerin, 1,3-butanediol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2 , 4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol, etc.
Examples of moisturizing ingredients include sodium pyrrolidonecarboxylate, lactic acid, sodium lactate, etc.
Examples of thickeners include guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, methyl hydroxypropyl cellulose, chondroitin sulfate, dermatan sulfate, glycogen , Heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, dextran, kerato sulfate, locust bean gum, succinoglucan, carolinic acid, chitin, chitosan, carboxy Methyl chitin, agar, polyvinyl alcohol, polyvinyl pyrrolidone, carboxy vinyl polymer Sodium polyacrylate, polyethylene glycol, bentonite and the like can be preferably exemplified.

As powders, for example, the surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, etc.
Examples of inorganic pigments include, for example, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, and zinc oxide, the surface of which may be treated.
Examples of pearl agents include, for example, mica titanium, fish phosphorus foil, bismuth oxychloride, etc. whose surface may be treated,
Examples of the organic dyes may be raked, red 202, red 228, red 226, yellow 4, blue 404, yellow 5, red 505, red 230, red 223. No., Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, etc.
Preferred examples of organic powders include polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, and the like.

Examples of the UV absorbers include paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane, etc.
Examples of lower alcohols include ethanol, isopropanol, and phenoxyethanol.
Examples of vitamins include vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B such as vitamin B12, vitamin B15 or derivatives thereof, and α-tocopherol , Β-tocopherol, γ-tocopherol, vitamin E acetates such as vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone and the like can be preferably exemplified.
Examples of the polymer having a bio-similar structure include polymethacryloyl lysine and polyglycosyl ethyl methacrylate.

Among these optional components, antibacterial polyhydric alcohols such as isoprene glycol, 1,2-pentanediol, 1,2-hexanediol, 2,4-hexylene glycol and 1,2-octanediol are used in the skin of the present invention. It is preferable to make it contain in an external preparation.
This is because by containing such antibacterial polyhydric alcohol, it is possible to reduce or eliminate the content of a substance that may induce a transient stimulus such as paraben to be blended for antiseptic purposes. In order to exert such effects, the total content of the antibacterial polyhydric alcohol is preferably 1 to 10% by mass, and 2 to 7% by mass with respect to the total amount of the external preparation for skin. Is more preferable. The antibacterial polyhydric alcohol may contain only one species or may contain two or more species in combination.

  The skin external preparation of the present invention is characterized by high storage stability, which is the first essential component, ascorbic acid or a derivative thereof, arbutin, tranexamic acid, 4-methoxysalicylic acid, or their It is presumed that melanin production-suppressing substances such as salts (which may be whitening components) are stabilized by quaternium, which is the second essential component. This is also explained in the examples described later.

The skin external preparation of this invention can be manufactured by processing the above-mentioned essential component and arbitrary component according to a conventional method.
The dosage form of the external preparation for skin of the present invention is not particularly limited as long as it can be applied to the skin, and examples thereof include a solubilized lotion dosage form, a thickening essence dosage form, and an emulsifier form.

The external preparation for skin of the present invention has a melanin production inhibitory action, and when applied to the skin, it suppresses the increase in melanin production at the application site, suppresses deterioration of pigmentation, and improves pigmentation. sell. By this action, a whitening effect is exhibited. Therefore, it is preferable that the skin external preparation of this invention appeals the effect | action which suppresses melanin production. For example, it is preferable that an indication of having an action of suppressing melanin production is described on the package of the external preparation, or an instruction to that effect is attached to the external preparation. Or it can also tell that the external preparation for skin of this invention has a melanin production inhibitory effect by advertisement or advertisement.

  The use of the external preparation for skin of the present invention is not particularly limited as long as it is intended to be applied to the skin for external use, and examples thereof include, for example, cosmetics, external preparations for skin, sundries for skin use, and the like. Among them, cosmetics are more preferable. In particular, the external preparation for skin of the present invention is preferably a quasi-drug cosmetic. Here, a quasi-drug means a quasi-drug defined by the Pharmaceutical Affairs Law.

The external preparation for skin of the present invention, which is a quasi-drug, preferably has a label based on the Pharmaceutical Affairs Law. For example, a display indicating that it has an action of suppressing the production of melanin that is increased by ultraviolet rays or the like, and a display of a suitable usage for suppressing the production of melanin are given.
The indication of suitable usage includes, for example, that an appropriate amount of the cosmetic of the present invention should be applied once or several times a day to a site where production of melanin is enhanced, and by the application, A display indicating that the application should be stopped immediately and a dermatologist should be consulted can be suitably exemplified when a tingling sensation is felt. Such a display may be posted on the back surface of the container filled with the cosmetic or the back surface of the package. It is also possible to write it down and attach it.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it is needless to say that the present invention is not limited to such examples.

<Example 1>
A cosmetic (lotion) was prepared according to the formulation shown in Table 1 below. That is, the prescription ingredients were heated to 80 ° C., stirred, solubilized, and cooled by stirring to obtain a lotion. This skin lotion is designated as cosmetic 1.

<Comparative Examples 1-3>
Comparative cosmetic 1 which is a skin lotion in which quaternium 33 which is a prescription component of cosmetic 1 is replaced with water, and comparative cosmetic 2 which is a skin lotion in which quaternium 33 which is a prescription component of cosmetic 1 is replaced with sodium polyacrylate Comparative cosmetic 3 which is a skin lotion in which ascorbic acid-2-glucoside, which is a formulation component of cosmetic 1, is replaced with water was prepared in the same manner as in Example 1.

<Test Example 1>
The high temperature preservation test of cosmetic 1 and comparative cosmetics 1 to 3 was performed. In the high temperature storage test, it was stored at 50 ° C. for 3 weeks. As control samples, the same samples as cosmetic 1 and comparative cosmetics 1 to 3, respectively, were stored at 5 ° C. After completion of storage, the color difference between each sample and the product stored at 5 ° C. was measured with an optical measuring instrument (“Color Difference Meter Minolta CR-300” manufactured by Minolta Co., Ltd.). These results are shown in Table 2.

From Table 2, the comparative cosmetics 1 and 2 (containing ascorbic acid-2-glucoside) after the test had a color difference from the control as compared with the comparative cosmetic 3 (containing no ascorbic acid-2-glucoside). You can see that it ’s big.
On the other hand, although the cosmetic 1 after the test contains ascorbic acid-2-glucoside, the color difference from the control is small. Therefore, it can be seen that the quaternium 33 improves the stability of ascorbic acid-2-glucoside, thereby enhancing the storage stability of the cosmetic.

<Example 2>
Cosmetics 2 to 5 (lotion) were prepared in the same manner as in Example 1 according to the formulation shown in Table 3 below.

<Test Example 2>
About the obtained cosmetics 2-5, when the same storage test as Test Example 1 was implemented, the results shown in Table 4 were obtained. From Table 4, it can be seen that various quaterniums have the effect of enhancing the storage stability of cosmetics.

<Example 3>
Cosmetics 10 to 13 (lotion) were prepared in the same manner as in Example 1 according to the formulation shown in Table 5 below.

<Test Example 3>
About the obtained cosmetics 6-9, the storage test similar to Test Example 1 was implemented. These results are shown in Table 6. From Table 6, it can be seen that the storage stability of the external preparation for skin containing various melanin production inhibitors is improved by quaternium.

  According to the present invention, it is possible to provide a whitening cosmetic composition having excellent stability. Further, according to the present invention, the whitening cosmetic can be easily stored.

Claims (7)

1) One or more selected from ascorbic acid and its derivatives, arbutin, tranexamic acid, 4-methoxysalicylic acid, and salts thereof;
2) A skin external preparation characterized by containing one or more selected from quaternium.   The skin external preparation according to claim 1, wherein the derivative of ascorbic acid is ascorbic acid phosphate ester or ascorbic acid-2-glucoside.   The content of one or more selected from the ascorbic acid and derivatives thereof, arbutin, tranexamic acid, 4-methoxysalicylic acid, and salts thereof is 0.1 to 10 mass based on the total amount of the external preparation for skin. The skin external preparation according to claim 1 or 2, wherein the skin external preparation is%.   Content of 1 type (s) or 2 or more types selected from the said quaternium is 0.01-5 mass% with respect to the skin external preparation whole quantity, The any one of Claims 1-3 characterized by the above-mentioned. The skin external preparation described in 1.   It is a cosmetic, The skin external preparation as described in any one of Claims 1-4 characterized by the above-mentioned.   The external preparation for skin according to any one of claims 1 to 5, which is a quasi-drug for suppressing melanin production.   The external preparation for skin according to any one of claims 1 to 6, characterized by appealing an inhibitory action on melanin production.