JP2005320321A - Dentifrice composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a dentifrice composition which can simply and whitely beautify teeth. <P>SOLUTION: This dentifrice composition contains ascorbic acid, an ascorbate, an ascorbic acid derivative, and hydroxyapatite. The ascorbic acid, the ascorbate, the ascorbic acid derivative are compounded in an amount of 0.01 to 15 %. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a dentifrice composition having a whitening effect, which contains ascorbic acid, ascorbates, an ascorbic acid derivative, and hydroxyapatite.

  Many people brush their teeth every day to prevent various diseases such as oral cleaning, tooth whitening, bad breath prevention, and alveolar pyorrhea. Various ingredients are blended into the dentifrice. In particular, many toothpastes containing a fluorine compound for the purpose of preventing tooth decay and whitening are commercially available. Hydroxyapatite is also formulated for the purpose of tooth decay prevention and whitening similar to fluorine compounds because it coats teeth.

  As an oral composition containing a fluorine compound for the purpose of whitening teeth, an oral composition containing a calcium compound, a fluorine compound, and an acidic compound (Japanese Patent Laid-Open No. 2002-104948) is a silica compound, An oral composition containing citrus oil (Japanese Patent Laid-Open No. 2002-104949) is a liquid toothpaste composition containing shellac (Japanese Patent Laid-Open No. 2002-370956), and a dentifrice composition containing various naturally derived ingredients. Various methods such as (Japanese Patent Laid-Open No. 2000-128753) have been proposed. Recently, bleaching, in which bleaching treatment is performed by applying bleaching agent such as hydrogen peroxide or urea peroxide to the tooth surface or injecting it into a dental drug retainer and attaching it to the tooth, is popular. Has been done.

  However, the whitening effect is not yet sufficient by the method using a dentifrice, and the method using a bleaching agent has problems such as a heavy burden on the patient and a pain because it requires guidance and treatment by a dentist.

  As a dentifrice using ascorbic acid and its salts, it contains ascorbic acid or ascorbates and starch degradation products such as dextrin for the purpose of bleaching and lightening coloring substances attached to the teeth to make the teeth whiter Powdered dentifrice composition (Japanese Patent Laid-Open No. 11-43424), ascorbic acid and sodium ascorbate are blended with polyethylene glycol, 1,3- By containing a dentifrice (JP-A-10-87459) dispersed in a dentifrice base such as butylene glycol, propylene glycol and concentrated glycerin, ascorbic acid and its derivatives, periodontal disease prevention and treatment effects were enhanced. An oral composition (Japanese Patent Laid-Open No. 9-175967) is disclosed.

JP 2002-104948 A JP 2002-104949 A JP 2002-370956 A JP 2000-128753 A JP-A-11-43424 Japanese Patent Laid-Open No. 10-87459 JP-A-9-175967

  An object of the present invention is to provide a dentifrice composition that is safe and can easily make a tooth white and beautiful.

  As a result of intensive studies to achieve the above object, the present inventors easily whitened teeth by brushing teeth with a dentifrice containing ascorbic acid, ascorbates, ascorbic acid derivatives and hydroxyapatite. I came to find what I can do beautifully.

  Hydroxyapatite is a kind of calcium phosphate, which is the main component of bone, and can be obtained naturally or synthetically and pulverized to about 30 μm or less.

  Ascorbic acid, sodium ascorbate, calcium ascorbate, potassium ascorbate, magnesium ascorbate, etc., ascorbic acid glucoside, ascorbyl palmitate, ascorbyl stearate, ascorbyl magnesium phosphate, etc. The amount of the ascorbic acid derivative is preferably 0.01 to 15% by weight, more preferably 4 to 10% by weight, based on the whitening effect of the teeth. The blending amount of hydroxyapatite is preferably 0.01% by weight based on the whitening effect, more preferably 50% by weight and more preferably 4 to 20% by weight based on the feeling of manufacture and use. Furthermore, the ratio of hydroxyapatite to ascorbic acid, ascorbate or ascorbic acid derivative is preferably 0.1 to 100 times, more preferably 0.2 to 50 times the whitening effect.

  In the present invention, ascorbic acids and hydroxyapatite can be added to the dentifrice at any time during the manufacturing process of the product, and may be mixed with the remaining raw materials. It is most desirable to mix with other raw materials after mixing in advance.

It can contain additives, humectants, foaming agents, fragrances, sweeteners, preservatives, various active ingredients and the like that are usually used in the dentifrice composition of the present invention. Specific examples of these components are shown below.
Abrasive: calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, silica, aluminum silicate, aluminum hydroxide, alumina, zeolite, titanium oxide, zirconium silicate and the like.
Wetting agent: glycerin, propylene glycol, polyethylene glycol, sorbitol, xylitol, etc.
Foaming agent: sodium lauryl sulfate, sodium N-lauroyl sarcosine, nonionic surfactant and the like.
Thickener: hydroxyethylcellulose, sodium carboxymethylcellulose, carrageenan, carboxyvinyl polymer, chitansan gum, gelatin, pullulan, sodium alginate and the like.
Preservatives: paraoxybenzoic acid ester, alkyldiaminoethylglycine hydrochloride, methylparaben, ethylparaben, sodium benzoate and the like.
Perfume: menthol, spearmint oil, lemon oil, eucalyptus oil, etc.
Sweetening agents: sodium saccharin, stevia extract, aspartame, etc.
Other medicinal ingredients: allantoin, tocopherol acetate, isopropylphenol, β-glycyrrhetinic acid, triclosan, chlorhexidine, dextranase, chlorophyll, flavonoid, tranexamic acid, hinokitiol and the like.
In addition, the compounding quantity of these arbitrary components is used suitably in the range accept | permitted pharmacologically, without preventing the effect of this invention.

  EXAMPLES Examples and test examples of the present invention will be described below, but the scope of the present invention is not limited thereby.

  ADVANTAGE OF THE INVENTION By this invention, the dentifrice composition which can make a tooth | gear white easily be safe and can be provided easily.

  Hereinafter, the present invention will be described in detail with reference to examples.

  Examples 1 to 9 and reference examples are shown in Tables 1 and 2.

[Comparative example]
For comparison, the following dentifrice was prepared.
Comparative Examples 1-9: Hydroxyapatite-free dentifrice of Examples 1-9 Comparative Example 10: Hydroxyapatite-free dentifrice of Reference Example Comparative Examples 11-19: Ascorbic acid and sodium ascorbate of Examples 1-9, And ascorbic acid glucoside-free dentifrice Comparative Example 20: Reference example sodium ascorbate-free dentifrice

[Whiteness test]
Each toothbrush of Examples 1-9, Reference Examples, and Comparative Examples 1-20 is attached to the toothbrush by 1 g each, and using a brushing device, 5 minutes for 6 minutes per day, all under the same conditions, 3 per case The extracted teeth were brushed one by one.
The whiteness before brushing of the extracted tooth and the whiteness after brushing for 5 days were measured with a colorimeter “CMS-35FS” manufactured by Murakami Color Research Laboratory. For each example, the average value of the measured values of three extracted teeth before brushing and the average value of the measured values of three teeth after brushing for 5 days were calculated.

  The value after brushing for 5 days is expressed as a value obtained by subtracting the average value before brushing from the average value after brushing, and the results are shown in Tables 3 and 4.

  From the results of Tables 3 and 4, in the dentifrices containing hydroxyapatite and containing no ascorbic acid of Comparative Examples 11 to 19, the whiteness of the teeth increases as the amount of hydroxyapatite increases. In the dentifrice containing the ascorbic acids without the hydroxyapatite blend of Comparative Examples 1 to 10, there is no correlation between the blending amount of the ascorbic acids and the whiteness of the teeth, and the whiteness is not so increased.

From the results of Tables 5 and 6, the dentifrice containing the ascorbic acids of Examples 1 to 9 and hydroxyapatite was compared with the dentifrice containing hydroxyapatite and containing no ascorbic acids of Comparative Examples 11 to 19. The whiteness has increased greatly. Especially when 4% or more of ascorbic acid was blended, a large increase in whiteness was observed.
In the dentifrice compounded with 3.0% hydroxyapatite as a reference example, although an increase was observed, no significant increase was observed.

Claims (5)

  A dentifrice composition containing ascorbic acid, ascorbates, an ascorbic acid derivative, and hydroxyapatite.   The dentifrice composition according to claim 1, wherein the amount of ascorbic acid, ascorbate, and ascorbic acid derivative is 0.01 to 15%.   The dentifrice composition according to claim 1, wherein the amount of ascorbic acid, ascorbate, and ascorbic acid derivative is 4 to 10%.   The dentifrice composition according to any one of claims 1 to 3, wherein the amount of hydroxyapatite is 4 to 50%. The dentifrice composition according to any one of claims 1 to 4, wherein the ratio of hydroxyapatite to ascorbic acid, ascorbates, and ascorbic acid derivatives is 0.1 to 100 times.