JP2005200350A - Carbonated foot bath - Google Patents

Abstract

An object of the present invention is to provide a carbonic acid footbath that can maintain the carbon dioxide concentration in hot water during a footbath for 5 to 30 minutes at 1000 mg / L or more.
SOLUTION: Carbonate and / or bicarbonate (A) is 20 to 60% by mass, organic acid (B) is 9 to 50% by mass, hygroscopic agent (C) is 10 to 70% by mass, and melting point is 40 ° C. A carbonated foot bath with a surfactant (D) having an HLB of 2 to 10 in an amount of 0.1 to 10% by mass [Selection] No selection

Description

  The present invention relates to a carbonated footbath that provides a high concentration of dissolved carbon dioxide equivalent to that of a natural carbonated spring.

Foot bathing is different from whole body bathing and can be applied to chronically ill patients and bedridden patients who are prohibited from bathing, and it is empirically known that foot bathing before going to bed promotes sleeping. A warm bath of 38 to 42 ° C. is generally used, and the foot bathing time is selected in accordance with the purpose within about 5 to 30 minutes (see Non-Patent Document 1).
On the other hand, warm baths in which carbon dioxide gas is dissolved have terminal vasodilatory action, skin blood flow increase action, and warmth maintenance action. In Europe, high concentration natural carbonated springs have been used for peripheral vascular disorders, hypertension, heart disease, etc. It has been used for treatment. By the way, natural carbonated springs are defined as having a free carbonate concentration of 1000 mg / L or more. However, in a carbonated warm bath using a commercially available carbonated bathing agent, the free carbonate concentration (free carbon dioxide concentration) is about 100 mg / L. The actual situation is lower than (see Non-Patent Document 2).

  Here, a footbath composition containing a carbonate compound, an acidic compound and a chlorinated isocyanuric acid compound as essential components (hereinafter referred to as a composition of the prior art) is known, and its effects are peripheral circulation disorder, obstruction Persons with poor blood flow, such as patients with atherosclerosis, those who need improvement in blood flow, warming the lower limbs, promoting sweating, promoting blood flow, improving skin blood circulation, ulcer sites and wounds In addition to being able to prevent and care for infection, it is described that reduction or disappearance of skin symptoms is observed by continuous use (see Patent Document 1). In the practice of the foot bath method with this prior art composition, the dissolved carbon dioxide concentration (free carbon dioxide concentration) is 300 to 3000 mg / L, preferably 500 to 1500 mg / L, and the free chlorine concentration is 1 to 100 mg. / L, preferably 10 to 50 mg / L.

By the way, people with poor blood flow, such as those with peripheral circulatory disorders, patients with obstructive arteriosclerosis, and those with serious symptoms such as those who need improvement in blood flow, are swollen by standing work When a person with a non-serious symptom, such as cold sleep and poor sleep, performs a foot bath using a composition of the prior art, it has not been possible to fully realize that the symptom has been improved.
When this cause was investigated, in the case of a person whose symptoms are not severe, the effect is difficult to realize, and the composition of the prior art is immediately dissolved in hot water, and the free carbon dioxide concentration is certainly up to about 1500 mg / L. However, it was found that it decreased to about 750 mg / L in 5 minutes. In the foot bath, the amount of hot water is as small as about 5L, and the depth of the hot water is as shallow as 10-15cm. Therefore, hot water with a dissolved carbon dioxide concentration of 1000mg / L or more can be obtained for a short time, but it takes 5-30 minutes. If the length is long, carbon dioxide escapes from the surface of the hot water surface, and it is difficult to maintain a high concentration of free carbon dioxide.

JP 2002-338468 A Ito, “Study on the effect of foot bathing on the skin temperature of the extremities”, Bulletin of Mie Prefectural College of Nursing, 1898, 10, p. 1-7 Shimooki, Sakai, Endo, Moritani, Sakakibara, Otsubo, Matsuo, Nakano, Fujimoto, “Study of optimal carbonic acid concentration and hot water temperature during artificial carbonic acid foot bathing by measuring foot dorsal skin blood flow”, Carbonic acid magazine, 1999, Volume 2, No. 1, p. 4-9

  An object of the present invention is to provide a carbonated foot bath agent capable of maintaining the carbon dioxide concentration in warm water at 1000 mg / L or more for 5 to 30 minutes during which the foot bath is performed so that the effect of the foot bath can be recognized. .

In order to solve the above-mentioned problems, the present inventors have (a) generating a high concentration of free carbon dioxide when the footbath is dissolved in hot water. By reducing the decrease in carbon, it was found that the carbon dioxide concentration can be maintained at 1000 mg / L or more in the same manner as natural carbonated spring for 5 to 30 minutes during foot bathing, and the present invention has been made. It was.
That is, in the present invention, the carbonate and / or bicarbonate (A) is 20 to 60% by mass, the organic acid (B) is 9 to 50% by mass, the hygroscopic agent (C) is 10 to 70% by mass, and the melting point is 40. It is a carbonated foot bath agent in which the surfactant (D) having a temperature of not lower than ° C. and an HLB of 2 to 10 is 0.1 to 10% by mass.

  The present invention has the effect of maintaining the free carbon dioxide concentration in hot water at 1000 mg / L or more for 5 to 30 minutes even when foot bathing is performed with a small amount of hot water as low as 5 L, and the foot is swollen by standing work. The effect of foot bathing can be expected even for those with non-serious symptoms such as poor coldness and poor sleep.

Hereinafter, the present invention will be described in detail.
The present invention (a) generates a high concentration of free carbon dioxide when the footbath is dissolved in warm water, (b) reduces the carbon dioxide generated by volatilization of the generated carbon dioxide from the hot water surface Solved the problem.
Regarding (a) above, it can be easily inferred that it is important to increase the contents of the bicarbonate (A) and the organic acid (B), which are components that generate free carbon dioxide.
As described above, since free carbon dioxide is generated by the reaction of (A) and (B), it is preferable to consider the ratio of (A) to (B). Theoretically, (A) is When one mole of (B) is present per mole, free carbon dioxide can be generated most efficiently, but not all the components dissolved in hot water are used for the reaction, and impurities are mixed in the raw material. Therefore, it can be easily guessed that it is only a guide.

However, in (A) and (B) alone, carbon dioxide is generated by moisture in the air during foot bath preparation production, storage, and transportation, and 1000 mg / L or more for 5 to 30 minutes during foot bathing. It was found that carbon dioxide that can maintain a high concentration of free carbon dioxide cannot be effectively dissolved in hot water.
Therefore, in the present invention, (A) is solved by including the hygroscopic agent (C) as the third component in addition to (A) and (B).
Regarding (i) above, carbon dioxide is volatilized from the hot water surface by covering the hot water surface with foam composed of a surfactant (D) having a melting point of 40 ° C. or higher and an HLB of 2 to 10. Solved by mitigating.

Hereinafter, each component will be described in detail.
First, the carbonate and / or bicarbonate (A) is a component that generates free carbon dioxide with the organic acid (B), and in order to increase the concentration to 1000 mg / L or more, (A) is 20 to 60 mass. %. Preferably, it is 25-50 mass%.
Specific examples of (A) include sodium carbonate, sodium bicarbonate, sodium sesquicarbonate (trisodium dicarbonate), potassium carbonate, potassium bicarbonate, ammonium carbonate, and the like, and mixtures thereof. Preferably, sodium bicarbonate whose pH is not so alkaline even when dissolved in warm water is blended with at least 25% by mass as a main component. When only sodium hydrogen carbonate is used for (A), if the amount of hot water is 5 L, the concentration of free carbon dioxide will be 1000 mg / L or more if (A) is contained in about 10 g or more in the foot bath.

More preferably, even if the above components are decomposed by moisture in the air, sodium carbonate that absorbs carbon dioxide generated by the decomposition and changes into sodium hydrogen carbonate is about 1 to 15% by mass of the total amount of the foot bath. This is the case of coexistence. However, when the amount of sodium carbonate exceeds 15% by mass, although depending on the blending amount of the organic acid (B) described below, the pH of the hot water tends to be 6.5 or more. In this state, carbon dioxide is CO ₃ ^2- ion or It exists in the state of HCO ₃ ⁻ , and the proportion of free carbon dioxide that exhibits terminal vasodilatory action, skin blood flow increase action, warmth maintenance action, etc. tends to decrease.
Next, the organic acid (B) reacts with (A) to generate free carbon dioxide and to maintain the free carbon dioxide concentration by keeping the warm bath weakly acidic (pH = 5.0 to 6.5). There is. In order to exhibit this effect, (B) needs 9-50 mass%. Preferably, it is 25-50 mass%.

Specific examples of (B) include succinic acid, acetic acid, oxalic acid, glutaric acid, tartaric acid, citric acid, phthalic acid, fumaric acid, malic acid, adipic acid, and salts thereof. Moreover, the mixture of the said compound may be sufficient.
Further, the hygroscopic agent (C) has a role of preventing (A) from being decomposed and releasing carbon dioxide by moisture in the air while the carbonated foot bath of the present invention is stored. In particular, the carbonated foot bath of the present invention has a high hygroscopic content of (A) and (B) in order to make the dissolved carbon dioxide concentration in the warm bath as high as 1000 mg / L or more. In order to exhibit the desired performance even if the agent is stored for about 2 years, the hygroscopic agent (C) needs to be 10 to 70% by mass. Preferably, it is 20-60 mass%.

Specific examples of (C) include anhydrous aluminum sulfate, anhydrous calcium chloride, anhydrous cobalt chloride, anhydrous magnesium sulfate, anhydrous nickel chloride, anhydrous sodium carbonate, anhydrous sodium dihydrogen pyrophosphate, anhydrous disodium phosphate, and anhydrous sodium metasilicate. , Anhydrous sodium sulfate, anhydrous sodium sulfite, anhydrous sodium tetraborate, anhydrous sodium thiosulfate, anhydrous zinc sulfate, etc., which can be present in anhydrous products and can incorporate a large amount of water into the crystal structure, activated carbon, silica gel, high Examples include molecular absorbers. Moreover, the mixture of the said compound may be sufficient.
Further, the surfactant (D) needs to have a melting point of 40 ° C. or higher and HLB of 2 to 8 in order to reduce the volatilization of carbon dioxide by covering the hot water surface with foam. Here, HLB (Hydrophilic-Lipophilic Balance) is an index indicating the degree of hydrophilicity and hydrophobicity of a compound. The higher the value, the stronger the hydrophilicity. (Refer to the 2nd revised edition, oleochemicals manual, 1982, Maruzen, page 710) The content of the surfactant (D) needs to be 0.1 to 10% by mass. Preferably, it is 0.5-5.0 mass%.

When the melting point of (D) is less than 40 ° C., the carbonated foot bath of the present invention is melted during storage or transportation, and the product performance is significantly impaired.
If the HLB of (D) is less than 2, a uniform foam film cannot be formed on the molten metal surface. On the other hand, if the HLB exceeds 10, even if (C) is contained, the foot bath agent is absorbed during production, storage and transportation, and the decomposition of (A) is promoted. Moreover, when shape | molding into a tablet, it is inferior to the peelability from a type | mold.
When the content of (D) is less than 0.1% by mass, the amount of foam generated is insufficient. When the content is more than 10% by mass, the footbath is produced, stored and transported even if (C) is contained. It absorbs moisture and promotes decomposition of (A).

  Specific examples of (D) include glycerol fatty acid esters such as glycerol monostearate and diglycerol distearate, sorbitan fatty acid esters such as sorbitan palmitate and sorbitan stearate, polyoxyethylene (5) glycerol stearate, polyoxy Examples thereof include polyoxyethylene fatty acid esters such as ethylene (2) glyceryl stearate, sucrose fatty acid esters such as sucrose-cured tallow ester, and sucrose stearate. Preferably, it is fine powder and has a low water content, and specific examples thereof include sucrose fatty acid esters F-20, F-50, F-70, F-90 (all trade names) manufactured by Daiichi Kogyo Seiyaku Co., Ltd. ).

Preferably, a bactericidal agent may be contained in the carbonated footbath of the present invention as long as the performance of the carbonated footbath of the present invention is not impaired.
Specific examples of the disinfectant include dichloroisocyanuric acid and salts thereof, trichloroisocyanuric acid and salts thereof, chlorine compounds such as hypochlorite, iodine compounds such as potassium iodide, isopropylmethylphenol, resorcin, hinokitiol, Derived from phenolic fungicides such as parachlorometacresol and triclosan, cationic bactericides such as benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, chlorhexidine chloride, chlorhexidine gluconate, catechins, horseradish extract, chitosan and other natural products The compound of this is mentioned.

Furthermore, when molding ingredients, moisturizers, herbal medicines, essential oils, amino acids, enzymes such as proteolytic enzymes and lipolytic enzymes, vitamins such as vitamin C and vitamin E, and foot baths contained in mineral springs into granules and tablets The emulsifying agent and lubricant used, as well as pigments, fragrances, foaming agents, oils, and the like may be contained within a range that does not impair the performance of the carbonated foot bath of the present invention.
Specific examples of components contained in the mineral spring include sodium chloride, ammonium chloride, fluoride, borax, boric acid and its compounds, anhydrous silicic acid and its salts, metasilicic acid and its salts, sodium phosphate, sodium polyphosphate, phosphorus Examples include calcium oxyhydrogen and sulfur compounds.

Specific examples of the humectant include glycerin, polyethylene glycol, sorbitol, polyvinyl alcohol, polyvinyl pyrrolidone, nuka oil, collagen, lanolin, hyaluronic acid, lactic acid and its salt, glutamic acid and its salt, and algae.
Specific examples of herbal medicines include spruce, shobu, aloe, oat, mugwort, peach leaf extract, and toki.
Specific examples of essential oils include rosemary, chamomile, lemon, lemongrass, thyme, lavender, jasmine, limonene, eucalyptus oil, mint and the like.
Specific examples of amino acids include glycine, leucine, aspartic acid, glutamic acid and the like.

In any case, those recognized as raw materials for quasi drugs and cosmetics are preferred.
The form of the carbonated foot bath of the present invention may be any form that can be dissolved in warm water such as fine powder, granules, and tablets, and is preferably a granule or tablet for reasons such as powder not dancing.
Moreover, the amount of the carbonated foot bath of the present invention is such that when the foot bath is composed only of the above (A), (B), (C), (D), the disinfectant and the fragrance, the amount of hot water is 5L. About 30-50g becomes a standard.
Moreover, when performing a foot bath using the carbonated foot bath agent of this invention, it is common to perform the temperature of warm water at about 35-42 degreeC. In healthy volunteers, the effects of free blood carbon dioxide on terminal vasodilation and skin blood flow increase were confirmed even at 35 ° C. However, it is difficult to feel warmth at 38 ° C or lower. It is preferable to maintain. Moreover, when performing a foot bath using the carbonated foot bath agent of this invention, it is preferable to be immersed in warm water to the ankle.

  For the foot bath, it is preferable to use a foot bath capable of keeping heat (insulating) or controlling the temperature, and the size of the foot bath has an opening into which both feet can enter and can be immersed in warm water until the ankle comes. Since the agent forms a foam film on the hot water surface, it is preferable that the agent has a depth that prevents the foam from overflowing from the container. For example, if the shape of the opening is circular, the diameter is 25 to 30 cm and the depth is about 15 to 20 cm.

The present invention will be specifically described below.
First, the evaluation methods used below are summarized.
(1) Free carbon dioxide concentration [CO ₂ (mg / L)]
5 L of hot water at 40 ° C. was placed in a cylindrical foot bath having a diameter of 25 cm and a depth of 15 cm, and a foot bath was prepared by adding a carbonated foot bath to the hot water. Free carbon dioxide in the footbath was measured every 5 minutes immediately after the carbonated foot bath was added.
In addition, free carbon dioxide concentration is 7-30 carbon dioxide, hydrogen carbonate ion and carbonate ion quantification of Ministry of the Environment natural environment station, mineral spring analysis method guideline (April, 2002), (2) capacity method of free carbon dioxide (Page 68). The time in the summary table is the elapsed time after the carbonated foot bath was added.

(2) Practical evaluation We asked 30 women who were standing and working everyday around the age of 30 to have a swollen foot for 15 minutes for 3 days and heard their ugly impressions. The evaluation is “◎” when the proportion of people who answered that the swelling of the foot has been reduced is 85% or more, “◯” when the proportion is 70% or more and less than 85%, and “△” when the proportion is 50% or more and less than 70%. ", Less than 50% was taken as" x ".
The present invention will be described based on examples.

[Example 1]
29.4% by weight of sodium hydrogen carbonate as the carbonate and / or bicarbonate (A), 29.4% by weight of succinic acid as the organic acid (B), and 39.2% anhydrous sodium sulfate as the moisture absorbent (C) 2% DK ESTER S-50 (trade name) (melting point: 63 ° C., HLB: 6) manufactured by Daiichi Kogyo Seiyaku Co., Ltd. as a surfactant (D) having a mass%, melting point of 40 ° C. or higher and HLB of 2 to 10 Mass%, each weighed and mixed to obtain a white powder mixture. This mixture was sealed every 35 g in a biaxially stretched polypropylene film / polypropylene casting film = 40 μm / 30 μm laminated film bag (hereinafter abbreviated as a polypropylene bag) to prepare a carbonated foot bath package (Sample No. 1). 1). The sealed product was left in a constant temperature and humidity chamber at 40 ° C. and 70% RH for 3 months.
After leaving, the contents were evaluated according to the above evaluation method. The evaluation results are shown in Table 1.

[Comparative Example 1]
In Example 1, the same evaluation as Example 1 was repeated except that DK ester S-50 manufactured by Daiichi Kogyo Seiyaku Co., Ltd. was not blended as (D) (Sample No. 2). The evaluation results are shown in Table 1.

In Table 1, in the carbonated footbath of the present invention (Example 1), the free carbon dioxide concentration in the footbath is maintained at 1000 mg / L or more immediately after being added to the hot water, and 93% (28 persons) in practical evaluation. The evaluator was able to feel improvement in swelling of the feet.
On the other hand, in the carbonated footbath of (Comparative Example 1), the concentration of free carbon dioxide was 1500 mg / L as soon as it was added to warm water, which was 1000 mg / L or more like the carbonated footbath of the present invention, but after 750 mg / L after 5 minutes. L and significantly below 1000 mg / L. In practical evaluation, only 20% (6 persons) of evaluators could realize the effect.

[Example 2]
In Example 1, instead of DK ester S-50 (trade name) manufactured by Daiichi Kogyo Seiyaku Co., Ltd. blended as (D), DK ester F-20W (trade name) manufactured by Daiichi Kogyo Seiyaku Co., Ltd., with HLB of 2 The same operation as in Example 1 was repeated except that F-90 (trade name) (melting point: 59 ° C., HLB: 9.5) having a melting point of 65 degrees, HLB: 2) and an HLB of 9.5 was used. (Sample No. 3 and No. 4 respectively). The evaluation results are shown in Table 2.

[Comparative Example 2]
In Example 1, instead of DK ester S-50 (trade name) manufactured by Daiichi Kogyo Seiyaku Co., Ltd. blended as (D), DK ester F-10 (trade name) manufactured by Daiichi Kogyo Seiyaku Co., Ltd., with HLB of 1 ( The same operation as in Example 1 was repeated except that F-110 (trade name) (melting point: 59 ° C., HLB: 11) having an HLB of 11 and a melting point of 65 ° C., HLB: 1 was used (samples respectively). No. 5, No. 6). The evaluation results are shown in Table 2.

In Table 2, sample No. which is a carbonated footbath of the present invention using a surfactant having an HLB of 2 to 10. 3 and no. In No. 4, the free carbon dioxide concentration was maintained at 1000 mg / L or more, and 93% of the people in both practical evaluations realized the effect.
However, sample No. 1 using a surfactant having an HLB of 1 was used. 5. Sample No. using a surfactant having an HLB of 11 No. 6 has a free carbon dioxide concentration of less than 1000 mg / L. 5 is 27%, sample no. 6 was 53%, both inferior to the carbonated foot bath of the present invention.

[Example 3]
(A) 29.4% by mass of sodium bicarbonate, (B) 29.4% by mass of succinic acid, (C) 41.1% by mass of anhydrous sodium sulfate, (D) Daiichi Kogyo Seiyaku Co., Ltd. DK ester S-50 (trade name) manufactured was 0.1% by mass, and each was mixed after weighing to obtain a white powder mixture. Thereafter, this mixture was formed into a diameter of 38 mm × thickness of 18 mm and a weight of 35 g using a tableting machine, and sealed in a polypropylene bag to prepare a package of carbonated foot bath agent (Sample No. 7).
In addition, (A) is 29.4% by mass of sodium bicarbonate, (B) is 29.4% by mass of succinic acid, (C) is 31.2% by mass of anhydrous sodium sulfate, and (D) is Daiichi Kogyo Seiyaku. DK ESTER S-50 (trade name) manufactured by the company was weighed and mixed to obtain a white powder mixture, and then molded into a diameter of 38 mm x thickness of 18 mm and a weight of 35 g using a tableting machine. A carbonated foot bath agent was prepared by enclosing in a polypropylene bag (Sample No. 8).
The sealed product was left in a constant temperature and humidity chamber at 40 ° C. and 70% RH for 3 months, and then the contents were evaluated according to the above evaluation method.

[Comparative Example 3]
(A) 30.0 mass% sodium bicarbonate as (A), 30.0 mass% succinic acid as (B), 40.0 mass% anhydrous sodium sulfate as (C) Then, the mixture was molded into a diameter of 38 mm × thickness of 18 mm and a weight of 35 g using a tableting machine, and sealed in a polypropylene bag to prepare a package of a carbonated foot bath agent (Sample No. 9).
(A) 29.4% by mass of sodium bicarbonate, (B) 29.4% by mass of succinic acid, (C) 21.2% by mass of anhydrous sodium sulfate, and (D) Daiichi Kogyo Seiyaku DK Ester S-50 (trade name) manufactured by the company was weighed and mixed to obtain a white powder mixture, and then molded into a diameter of 38 mm x thickness of 18 mm and a weight of 35 g using a tableting machine. Then, it was enclosed in a polypropylene bag to produce a package of carbonated foot bath agent (Sample No. 10).
The sealed product was left in a constant temperature and humidity chamber at 40 ° C. and 70% RH for 3 months, and then the contents were evaluated according to the above evaluation method.

In Table 3, sample No. which is the carbonated foot bath of the present invention having a content of (D) in the range of 0.1 to 10% by mass. 7 and no. No. 8 maintains a free carbon dioxide concentration of 1000 mg / L or more. 7 is 97%, sample no. In 8, 93% of people felt the effect.
However, sample No. containing no (D). 9, Sample No. having the same content of 20% by mass. No. 10 has a free carbon dioxide concentration of less than 1000 mg / L. 9 is 40%, sample no. 10 was 47%, both inferior to the carbonated foot bath of the present invention.
There were many opinions that tableting compared to powder facilitated handling and that the foam became creamy and the usability was superior to that of powder.

[Example 4]
(A) 29.4% by weight of sodium bicarbonate, (B) 29.4% by weight of succinic acid, (C) 39.1% by weight of anhydrous sodium sulfate, and (D) Daiichi Kogyo Seiyaku Co., Ltd. DK Ester S-50 (trade name) manufactured by 2.0% by mass and sodium dichloroisocyanurate 0.1% by mass as a bactericide were weighed and mixed, and then used in a tableting machine with a diameter of 38 mm, a thickness of 18 mm, and a weight of 35 g. And sealed in a polypropylene bag to produce a carbonated foot bath package (Sample No. 11).
The sealed product was left in a constant temperature and humidity chamber at 40 ° C. and 70% RH for 3 months, and then the contents were evaluated according to the above evaluation method.
The free carbon dioxide concentration was substantially the same as in Example 1, and the practical evaluation was 97%, which was slightly higher than that in Example 1. Many of the evaluators' free opinions expressed a refreshing feeling after taking a foot bath.

  INDUSTRIAL APPLICABILITY The present invention can be suitably used in the field of foot bathing for relief of symptoms by a person who suffers from swelling of feet during standing work, coldness and poor sleep at night.

Claims (1)

  Carbonate and / or bicarbonate (A) is 20 to 60% by mass, organic acid (B) is 9 to 50% by mass, hygroscopic agent (C) is 10 to 70% by mass, melting point is 40 ° C. or higher, and HLB A carbonated footbath in which the surfactant (D) having 2 to 10 is 0.1 to 10% by mass.