JP2005097121A - Maintaining or improving motor function - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an agent for maintaining or improving motor function, which has high stability and safety and exhibits an excellent effect for maintaining and improving the motor function of the body.
And A coenzyme Q ₁₀ and carnitine an active ingredient, preferably as a further active ingredient, citric acid, succinic acid, fumaric acid, lactic acid, gluconic acid, one or more selected from the group consisting of malic acid and tartaric acid An agent for maintaining or improving motor function, containing an organic acid.
[Selection figure] None

Description

The present invention relates to maintaining or improving agent of motor function as an active ingredient coenzyme Q ₁₀ and carnitine. The agent for maintaining or improving the motor function of the present invention may be ingested as it is, and may also be used by blending with foods and drinks, feeds, quasi drugs or cosmetics.

Coenzyme Q ₁₀ (molecular formula C ₅₉ H ₉₀ O _4, molecular weight 863.36) is a type of coenzyme Q present in higher animals known as ubidecalenone or coenzyme Q ₁₀ . Coenzyme Q ₁₀ is a low melting lipophilic solid, dissolves the like in ether or fat, which is poorly soluble in water. Moreover, coenzyme Q ₁₀ is dissolved like fat, its solubility is low, easily crystals precipitated. Moreover, coenzyme Q ₁₀ is the light, or the B vitamins, vitamin E, decomposes coexist such as gelatin, is an unstable substance which produces like hydroquinone body and Yubikuromenoru.

Coenzyme Q ₁₀ is a vitamin-like substance that not only has biological activity as a coenzyme, but also has an action of improving oxygen utilization efficiency. Thus, coenzyme Q _10, in addition to acting on the congestion tissue, believed to have effects such as stabilization and anti-oxidation of biological membranes, Clinically angina, heart failure, improving the symptoms of ischemic heart disease, It is known to be effective as a therapeutic agent for mild and moderate congestive psychiatric symptoms, and for preventing side effects of essential hypertension, periodontal disease, anticancer drugs and psychotropic drugs. In addition, it has been reported to be effective in preventing aging and restoring muscle fatigue. As described above, coenzyme Q ₁₀ is a highly safe substance that has high physiological activity and is present in the living body, and thus has attracted attention as a health food material.

  On the other hand, carnitine (4-trimethylamino-3-hydroxybutyric acid) has a gastric juice secretion promoting action, a gastric peristaltic movement promoting action, and the like, and is used for improving gastrointestinal symptoms. Carnitine is involved in fatty acid oxidation in mitochondria, and is known to have an action of promoting lipid metabolism, reduce neutral lipids in the blood, and prevent fatty liver. In addition, it is known that the effect increases synergistically in combination with exercise, the exercise duration is significantly prolonged, and the maximum work is significantly increased.

Combination Examples of these coenzyme Q ₁₀ and carnitine are known some. For example, Patent Document 1 discloses that to a combination of coenzyme Q ₁₀ and carnitine hypoxia therapeutic agent. Further, Patent Document 2, the fatigue improving agent has been proposed which contains a coenzyme Q ₁₀ and carnitine. However, a combination of coenzyme Q ₁₀ and carnitine, by ingesting, physical exercise function maintains, has not been known to be improved.
Japanese Patent Publication No. 2-7572 Japanese Patent Laid-Open No. 7-330584

  An object of the present invention is to provide an agent for maintaining or improving motor function, which has high stability and safety and exhibits an excellent effect in maintaining and improving the motor function of the body.

The present inventors have found that in considering the addition of coenzyme Q ₁₀ and carnitine food materials in nutritional products, a combination of coenzyme Q ₁₀ and carnitine, by ingesting, maintaining body motor function, the effect of improving I found out that it was played.
The present invention, which has been completed based on such findings, by providing maintenance or improvement agent of motor function as an active ingredient coenzyme Q ₁₀ and carnitine is obtained by achieving the above object.
Moreover, this invention provides the food-drinks, feed, quasi-drug, or cosmetics which mix | blended the maintenance or improvement agent of said motor function of this invention.

The agent for maintaining or improving the motor function of the present invention has high stability and safety, and exhibits an excellent effect in maintaining and improving the motor function of the body.
In addition, foods and drinks containing the agent for maintaining or improving motor function of the present invention are ingested daily as solid foods such as granules, tablets, capsules, liquid foods such as drinks, beverages, and liquid foods, and functional foods. Thus, the motor function can be maintained and improved, and can be preferably used for middle-aged and elderly people who tend to lack exercise, frail elderly people whose motor function is reduced, and the like.

Hereinafter, the motor function maintaining or improving agent of the present invention will be described in detail.
Coenzyme Q ₁₀ is a a poorly water soluble material, for example as in Nisshin CoQ ₁₀ water-soluble liquid manufactured by Pharma Ltd. 10S or water-soluble powder 5%, is commercially available in emulsified coenzyme Q ₁₀ ing. In the present invention, it may be used as it is coenzyme Q _10, can also be a commercially available product emulsified such coenzyme Q _10. Coenzyme Q ₁₀ with those obtained by emulsification when incorporated in an aqueous liquid such as a beverage, dissolved, excellent dispersibility, because there is no readily be aggregation and precipitation preferable.

In addition, as carnitine used in combination with coenzyme Q ₁₀ in the present invention, carnitine chloride, L-carnitine, L-carnitine tartrate, L-carnitine fumarate, L-carnitine magnesium salt, acetylcarnitine, propionylcarnitine and the like are naturally extracted. All carnitine can be used regardless of the product, fermented product and synthetic product.

The content of coenzyme Q _{10 and} the content of carnitine are not limited, and the optimal daily intake of coenzyme Q ₁₀ and carnitine, the dosage form of the maintenance or improvement agent of the motor function of the present invention, When the agent for maintaining or improving the motor function is added to other products such as foods and drinks, feeds, quasi-drugs, and cosmetics, it is appropriately determined in consideration of the types and forms of these products. However, the coenzyme Q ₁₀ content is preferably 0.0001 to 50% by mass, more preferably 0.1 to 40% by mass, and the carnitine content is preferably 0.000003 to 60% by mass. %, More preferably 0.5 to 50% by mass. Specifically, for example a tablet, in the case of such capsules, powders or granules, the content of coenzyme Q ₁₀ is generally in the range of 0.01 to 50 wt%, preferably 0.5 About 20% by mass. Incidentally, daily intake of coenzyme Q ₁₀ age, varies depending weight and health, for adults, 5 to 300 mg, preferably 10-100 mg. The content of carnitine varies depending on the type of carnitine, but in the case of powders or granules, it is generally in the range of 0.03 to 60% by mass, preferably 0.1 to 30% by mass. %. The daily intake of carnitine varies depending on age, weight and health, but is usually 50 to 1000 mg, preferably 100 to 500 mg for adults.

In the agent for maintaining or improving motor function of the present invention, the blending ratio of coenzyme Q ₁₀ and carnitine is preferably 20 to 4000 parts by mass, more preferably 30 to 3000 parts by mass with respect to 100 parts by mass of coenzyme Q _10. Parts, most preferably 50-2000 parts by weight.

Maintaining or improving agent of motor function of the present invention, in addition to the above coenzyme Q ₁₀ and carnitine, preferably further contains a organic acid as an active ingredient.
Preferred examples of the organic acid include citric acid, succinic acid, fumaric acid, lactic acid, gluconic acid, malic acid, and tartaric acid, and one or more of these are used.
The content of the organic acid is usually preferably 0.5 to 30% by mass, more preferably 0.5 to 25% by mass, and most preferably 1.0 to 20% by mass.
The mixing ratio of the coenzyme Q ₁₀ and carnitine and organic acids in the case of blending an organic acid to maintain or improving agent of motor function of the present invention, with respect to coenzyme Q ₁₀ 100 parts by weight, preferably carnitine 20-4000 Weight Parts and organic acid 0.01 to 2000 parts by weight, more preferably carnitine 30 to 3000 parts by weight and organic acid 0.5 to 1000 parts by weight, most preferably carnitine 50 to 2000 parts by weight and organic acid 1 to 500 parts by weight. is there.

The agent for maintaining or improving the motor function of the present invention includes tablets, capsules, granules, powders, powders, solutions, emulsions, syrups, suspensions, suppositories, ointments, creams, gels, patches, inhalations. It can be in any dosage form such as an agent and injection, and depending on these dosage forms, commonly used excipients, disintegrants, binders, lubricants, surfactants, alcohol, water, water-soluble Can be produced according to a conventional method by blending a functional polymer, sweetener, flavoring agent, acidulant and the like. In addition, when using it as a liquid agent, the form which melt | dissolves or suspends in water or another suitable medium at the time of taking may be sufficient. Moreover, when it is set as a tablet or a granule, you may coat by a well-known method.
Among the above dosage forms, the agent for maintaining or improving the motor function of the present invention is preferably a liquid, emulsion, or gel, and in that case, the pH of the agent for maintaining or improving the motor function of the present invention is 2. It is preferable to adjust to the range of 8 to 7.8, particularly 3.0 to 7.5.

The agent for maintaining or improving the motor function of the present invention may be ingested as it is, and may be used by mixing with foods and drinks, feeds, quasi drugs or cosmetics, and is particularly suitable for use in foods and drinks. is there.
Examples of the foods and drinks include nutritional foods preferably containing oral nutritional compositions and tube feeding compositions in the form of liquid foods, and other general foods and drinks such as drinks, tea beverages, and refreshments. It can also be used for beverages, milk beverages, butter, mayonnaise, shortening, margarine, various salad dressings, breads, noodles, pasta, confectionery (for example, cookies, chocolate, candy, chewing gum).

When the agent for maintaining or improving the motor function of the present invention is used as a liquid food, the content of coenzyme Q _{10 in} the liquid food is preferably 0.00001 to 1.0% by mass, more preferably 0.0001 to The content of carnitine is preferably 0.00003 to 2.0% by mass, more preferably 0.0001 to 1.0% by mass, and within the range of these contents, requirement per day of coenzyme Q ₁₀ and carnitine, is determined by further considering the dispersion stability and flavor of liquid food.

The liquid food preferably contains any one or more of protein, carbohydrate, lipid and dietary fiber as other nutritional components, and particularly contains any one or more of protein, carbohydrate and lipid. It is preferable to contain.
The protein content is 0 to 100 g / L, preferably 30 to 65 g / L, the carbohydrate content is 0 to 500 g / L, preferably 100 to 200 g / L, and the lipid content is 0 to 120 g / L, preferably 15 to 35 g / L, and the dietary fiber content is 0 to 50 g / L, preferably 0.5 to 45 g / L.
Moreover, it is preferable to adjust the content of each blended component so that the energy of the whole liquid food is 60 kcal or more per 100 ml, preferably 90 kcal or more. The upper limit of the energy is desirably 230 kcal / 100 ml.

Examples of the protein that can be blended in the liquid food include, for example, casein or casein salts such as sodium caseinate and calcium casein; animal proteins such as egg protein, milk protein and meat protein; vegetable proteins such as soybean protein and wheat protein A peptide such as soybean peptide; gelatin and the like. Moreover, you may use the hydrolyzate and amino acid of these proteins. Only one type of protein may be used, or two or more types may be used in combination.
The protein is preferably blended so as to supply 0 to 30%, preferably 10 to 25% of the total energy of the liquid food within the content range.

Examples of the sugar that can be blended in the liquid food include maltodextrin, dextrin, powdered rice, monosaccharides such as glucose and fructose, disaccharides such as maltose and lactose, granulated sugar, and oligosaccharide. Only one type of carbohydrate may be used, or two or more types may be used in combination.
The carbohydrate is preferably blended so as to supply 0 to 70%, preferably 50 to 70%, of the total energy of the liquid food within the content range.

Examples of the lipid that can be blended in the liquid food include vegetable oils such as rice bran oil, soybean oil, cottonseed oil, safflower oil, corn oil, rapeseed oil, palm oil, perilla oil, sesame oil, and coconut oil; animal oils such as beef tallow Fish oil; MCT; medium chain fatty acid triglycerides, other synthetic triglycerides, and the like. These may be used alone or in combination of two or more.
The lipid is preferably blended so as to supply 0 to 50%, preferably 15 to 30%, of the total energy of the liquid food within the content range.

  Examples of the dietary fiber that can be blended in the liquid food include indigestible polysaccharides such as cellulose, lignin, resistant starch, polydextrose, oligosaccharides, and guar gum degradation products. May be used alone, or two or more may be used in combination.

Vitamins, minerals, emulsifiers and the like conventionally added to this type of liquid food can be added to the above liquid food as necessary, in addition to the above components.
Examples of the vitamins include fats such as vitamin A, vitamin B1, vitamin B2, vitamin B12, vitamin B6, vitamin C, vitamin D, vitamin K, carotene, vitamin E, niacin, folic acid, pantothenic acid, inositol, and biotin. Soluble or water-soluble vitamins may be mentioned, and these may be used alone or in combination of two or more. The amount of the above vitamins is determined according to the intake (target intake) described in the 80-year-old boy's life vitality strength described in the 6th revised Japanese nutritional requirement (published by 1st publisher), for example. can do.

Examples of the emulsifier include glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, phospholipid, gum arabic, xanthan gum, tragan gum, guar gum and locust pea gum.
In addition to the above components, various ingredients such as nutritional components can be added. For example, garcinia extract, diacylglycerol, capsaicin, γ-aminobutyric acid, amino acids, agaricus koji extract, carrot extract, garlic extract, DHA, EPA, cysteine, cysteine peptide, glutamine peptide, soy isoflavone, turmeric, maca, carrot, yeast and other minerals, green juice, vinegar, collagen, soy isoflavone, each peptide, lecithin, royal jelly, propolis, glucosamine, mesimacob Taste components such as mycelium, glucosamine, chondroitin sulfate, sodium chloride, sodium glutamate, sodium citrate, liquid sugar, fruit juice, coffee flavor, matcha flavor, milk flavor and the like can be added.

Nutritional foods such as oral nutritional compositions and tube feeding compositions are mainly provided in the form of liquid foods, but are in the form of powders, solids, pastes, etc. obtained by mixing and drying the above components. In this case, they are taken directly or when dissolved or dispersed in water or hot water. The liquid food can be prepared according to a conventional method. That is, each component is weighed, put into water, mixed thoroughly, emulsified, filled and sealed in a retort pouch, and sterilized to produce a liquid food. Is liquid food obtained in this way, not only replenish nutrients and energy required for such frail elderly, because it contains a coenzyme Q _10, coenzyme Q ₁₀ has been difficult in the conventional liquid diet It can be supplied safely and without harming the flavor.

  When using the maintenance or improving agent for motor function of the present invention in foods and drinks other than the nutritional food, food materials, various nutrients, various vitamins, minerals, dietary fiber, various additives used in the production of the food and drink, For example, it can be produced according to a conventional method by blending a taste ingredient, a sweetener, an acidulant such as an organic acid, a stabilizer, a flavor, and the like with the maintenance or improving agent for motor function of the present invention. In the case of soft drinks such as carbonated drinks, tea drinks such as Japanese tea and black tea, and drinks such as various nutrients, the pH of the drink containing the maintenance or improving agent of the motor function of the present invention is 2.8-7. It is preferable to adjust to the range of 8, especially 3.0 to 7.5.

Hereinafter, the nutritional composition of the present invention will be described with reference to examples, but the present study is not limited to the following examples. In all examples, Nisshin Pharma Co., Ltd. Coenzyme Q ₁₀ (CoQ ₁₀ ) and carnitine were used.

Example 1
CoQ ₁₀ (Nisshin Pharma Co., Ltd.) 60 g, soybean oil (Yoshihara Oil Co., Ltd.) 365 g and glycerin fatty acid ester 15 g (Riken Vitamin Co., Ltd.) were mixed and heated to about 65 ° C. to dissolve. . Thereafter, the mixture was cooled to room temperature, 150 g of L-carnitine L-tartrate (manufactured by Lonza Co., Ltd.) and 10 g of malic acid (manufactured by Showa Kako Co., Ltd.) were added and stirred to produce a filling liquid. Using this filling liquid, 300 mg of soft capsules per capsule were produced by a conventional soft capsule production method.

Example 2
CoQ ₁₀ (Nisshin Pharma Co., Ltd.) 60 g, L-carnitine L-tartrate (Lonza Co., Ltd.) 200 g, crystalline cellulose (Asahi Kasei Co., Ltd.) 245 g, lactose (DMV Co., Ltd.) 70 g, HPC ( 20 g of Nippon Soda Co., Ltd., hydroxypropylcellulose) and 5 g of citric acid (manufactured by Tanabe Seiyaku Co., Ltd.) were mixed, and this mixture and 130 ml of ethanol were added to a kneader and kneaded for 5 minutes by a conventional method. . After kneading, the mixture was sieved with 10 mesh and dried at 50 ° C. in a dryer. After drying, the particles were sized to obtain contained granules.

Example 3
CoQ ₁₀ (Nisshin Pharma Co., Ltd.) 60 g, L-carnitine L-tartrate (Lonza Co., Ltd.) 200 g, crystalline cellulose (Asahi Kasei Co., Ltd.) 240 g, lactose (DMV Co., Ltd.) 70 g, HPC ( 20 g of Nippon Soda Co., Ltd.) was mixed, and this mixture and 130 ml of ethanol were added to a kneader and kneaded for 5 minutes by a conventional method. After kneading, the mixture was sieved with 16 mesh and dried at 50 ° C. in a dryer. After drying, the particles were sized to obtain contained granules.
To this granule, 10 g of sucrose fatty acid ester (Mitsubishi Chemical Corporation) was added and mixed for about 1 minute to produce a tableting powder. Using this powder, tablets of 300 mg per tablet were produced using a normal tableting machine.

Example 4
CoQ ₁₀ (Nisshin Pharma Co., Ltd.) 60 g, L-carnitine L-tartrate (Lonza Co., Ltd.) 200 g, crystalline cellulose (Asahi Kasei Co., Ltd.) 210 g, lactose (DMV Co., Ltd.) 70 g, HPC ( 20 g of Nippon Soda Co., Ltd.) was mixed, and this mixture and 130 ml of ethanol were added to a kneader and kneaded for 5 minutes by a conventional method. After kneading, the mixture was sieved with 16 mesh and dried at 50 ° C. in a dryer. After drying, the particles were sized to obtain contained granules.
To this granule, 30 g of citric acid (manufactured by Tanabe Seiyaku Co., Ltd.) and 10 g of sucrose fatty acid ester (manufactured by Mitsubishi Chemical Corporation) were added and mixed for about 1 minute to produce a tableting powder. Using this powder, tablets of 300 mg per tablet were produced using a normal tableting machine.

Example 5
CoQ ₁₀ (manufactured by Lonza Co.) emulsion in which CoQ ₁₀ water-soluble liquid 10S (produced by Nisshin Pharma Inc.) 3 g (300 mg as CoQ _10), L- carnitine L- tartrate 1.0 g, purified water 800g , 1.0 g of citric acid (manufactured by Tanabe Seiyaku Co., Ltd.) and 200 g of glucose solution (manufactured by Nippon Food Processing Co., Ltd.) were weighed and dissolved by stirring at room temperature to adjust the pH to 3.0 to 3.5. A fine and uniform CoQ _10- containing beverage composition was obtained.

Example 6
CoQ ₁₀ (Nisshin Pharma Co., Ltd.) 30 g, Vitamin B1 15 g, L-carnitine L-tartrate 200 g, crystalline cellulose (Asahi Kasei Co., Ltd.) 390 g, lactose (DMV Co.) 235 g, HPC (Nippon Soda ( A mixture of 20 g) and 10 g of citric acid (Tanabe Seiyaku Co., Ltd.) was granulated using 166 g of ethanol, dried at 50 ° C., and sieved through 16 mesh to obtain granules. The granules were filled with about 300 mg per capsule (containing 15 mg CoQ ₁₀ and 100 mg carnitine per capsule) using No. 2 hard capsules to obtain CoQ ₁₀ and carnitine-containing hard capsules.

Example 7
A liquid food was produced as follows. To 600 g of pure water at about 65 ° C., 10 g of sodium caseinate (manufactured by DMV), 40 g of calcium casein (manufactured by DMV) and 185 g of maltotextrin (manufactured by Matsutani Chemical) were dissolved. Minerals are added in a small amount as necessary, and 10 g of polyglycerin fatty acid ester (manufactured by Taiyo Kagaku Co., Ltd.), 70 g of rapeseed oil (manufactured by Nissin Oilio Co., Ltd.) and medium chain fatty acid ester (Nippon Yushi Co., Ltd.) )) 15 g, CoQ ₁₀ (Nisshin Pharma Co., Ltd.) 50 mg, L-carnitine (Lonza Co., Ltd.) 1.5 g are added, and after mixing the components, the mixture is put into a homomixer. The mixture was charged and roughly emulsified at about 9000 rpm for 10 minutes. Next, the mixture was heated to 60 ° C. and allowed to stand for 10 minutes, and then fine emulsification (300 kgf / cm ² 2 passes) was performed using a high-pressure emulsifier. The obtained emulsified liquid was cooled to about 20 ° C., and after addition of vitamins and a small amount of flavoring, the volume was increased. The filling tank was cooled to about 8 ° C., and the obtained emulsion was added while stirring at 200 rpm. Next, after filling the pouch with about 230 g of this liquid from the filling tank, the pouch was sealed with nitrogen substitution, and sterilized at 121 ° C. for 15 minutes to obtain a concentrated liquid food. The resulting concentrated liquid food had an energy of 100 kcal per 100 ml. As a result of analyzing this concentrated liquid food, the content of CoQ ₁₀ was 5 mg / 100 ml, the content of carnitine was 150 mg / 100 ml, the average particle size was 0.81 μm, pH 6.8, the osmotic pressure was 432 m0sm, A milky white emulsion with a slightly sweet flavor. This concentrated liquid food was good in the stability and flavor of the emulsion.

Example 8
2 g of dry yeast was mixed with 150 g of wheat flour (strong flour). On the other hand, 1 g of CoQ ₁₀ , 3 g of carnitine, 20 g of sugar, 3 g of salt and 6 g of skimmed milk powder were dissolved in 70 g of hot water, 1 egg was added and mixed well, and then 5 g of malic acid was added and further mixed. This was added to the flour mixed with the above dry yeast and kneaded well by hand, and then kneaded well with about 40 g of butter to prepare 20 roll bread dough. Next, after the dough was fermented, a beaten egg was applied on the surface and baked in an oven at 180 ° C. for about 15 minutes to produce a roll. This roll contained about 50 mg of CoQ ₁₀ and about 150 mg of carnitine per piece.

Example 9
Put a portion of meat sauce for pasta (150 g) in a pan, add 2 hard capsules prepared in Example 6 and dissolve 200 mg of carnitine while warming the meat sauce to obtain a meat sauce for pasta containing CoQ ₁₀ and carnitine. It was. After filling this pouch with a pouch, the pouch was sealed with nitrogen substitution and sterilized at 121 ° C. for 15 minutes to obtain a meat sauce for pasta.

Example 10
After adding 2 hard capsules produced in Example 6 to a general amount of water using 2 rices, adding 90 mg of carnitine, cooking rice, filling this into a retort pack according to a conventional method, and then substituting nitrogen. It sealed while performing, and it sterilized for 15 minutes at 121 degreeC, and obtained the retort rice. This retort rice contained about 30 mg of CoQ ₁₀ and 90 mg of carnitine per serving, and the appearance, taste and texture were good.

Example 11
A mixture of 300 g of wheat flour (medium flour), 1 g of CoQ ₁₀ , 3 g of carnitine and 15 g of sodium chloride in 150 g of water was mixed well and laid down. Thereafter, the dough was stretched and cut into widths of about 5 mm to produce udon. When this was boiled with boiling water for about 10 minutes, the appearance, taste and texture were good. This udon contained about 30 mg of CoQ ₁₀ and about 90 mg of carnitine per serving.

Example 12
In 200 ml of milk, 4.5 g of gelatin, 45 g of sugar and 15 g of water were put, and it was heated to dissolve the gelatin completely. After confirming that the gelatin was dissolved, 0.12 g of CoQ ₁₀ and 1.2 g of carnitine were thoroughly mixed and dissolved. Thereafter, the mixture was poured into 4 cups and cooled and hardened in a refrigerator for 2 hours or more to obtain milk jelly. The milk jelly contained about 30 mg CoQ ₁₀ and about 300 mg carnitine per serving.

Example 13
Glucose solution 800 g, purified water 3200 g and citric acid 0.5 g were mixed and dissolved, and CoQ ₁₀ aqueous solution 10S (Nisshin Pharma Co., Ltd.) 1.2 g and carnitine 1.2 g were added and dissolved. A beverage was produced. This beverage contained about 30 mg CoQ ₁₀ and about 300 mg carnitine per 1000 ml.

Comparative Example 1
200 g of L-carnitine L-tartrate (manufactured by Lonza), 240 g of crystalline cellulose (manufactured by Asahi Kasei), 100 g of lactose (manufactured by DMV) and 20 g of HPC (manufactured by Nippon Soda Co., Ltd.) The mixture and 130 ml of ethanol were added to a kneader and kneaded for 5 minutes by a conventional method. After kneading, the mixture was sieved with 16 mesh and dried at 50 ° C. in a dryer. After drying, the particles were sized to obtain contained granules.
To this granule, 30 g of citric acid (manufactured by Tanabe Seiyaku Co., Ltd.) and 10 g of sucrose fatty acid ester (manufactured by Mitsubishi Chemical Corporation) were added and mixed for about 1 minute to produce a tableting powder. Using this powder, tablets of 300 mg per tablet were produced using a normal tableting machine.

Comparative Example 2
60 g of CoQ ₁₀ (manufactured by Nisshin Pharma Co., Ltd.), 410 g of crystalline cellulose (manufactured by Asahi Kasei Co., Ltd.), 70 g of lactose (manufactured by DMV) and 20 g of HPC (manufactured by Nippon Soda Co., Ltd.) are mixed. 130 ml was added to the kneader and kneaded for 5 minutes by a conventional method. After kneading, the mixture was sieved with 16 mesh and dried at 50 ° C. in a dryer. After drying, the particles were sized to obtain contained granules.
To this granule, 30 g of citric acid (manufactured by Tanabe Seiyaku Co., Ltd.) and 10 g of sucrose fatty acid ester (manufactured by Mitsubishi Chemical Corporation) were added and mixed for about 1 minute to produce a tableting powder. Using this powder, tablets of 300 mg per tablet were produced using a normal tableting machine.

Comparative Example 3 (placebo grain)
467 g of crystalline cellulose (Asahi Kasei Co., Ltd.), 70 g of lactose (manufactured by DMV), 20 g of HPC (manufactured by Nippon Soda Co., Ltd.) and 3 g of yellow No. 5 dye are mixed, and this mixture and 120 ml of purified water are mixed in a kneader. The mixture was added and kneaded for 5 minutes by an ordinary method. After kneading, the mixture was sieved with 16 mesh and dried at 50 ° C. in a dryer. After drying, the particles were sized to obtain contained granules.
To this granule, 30 g of citric acid (manufactured by Tanabe Seiyaku Co., Ltd.) and 10 g of sucrose fatty acid ester (manufactured by Mitsubishi Chemical Corporation) were added and mixed for about 1 minute to produce a tableting powder. Using this powder, tablets of 300 mg per tablet were produced using a normal tableting machine.

Test example (1)
A test was conducted to evaluate the speed of recovery of heartbeat using the tablets obtained in Example 3 and Comparative Examples 1 to 3. The higher the score, the faster the recovery of cardiac function. In the test, a step-up / down test was performed, the heart rate was measured, and the recovery rate of the heart rate was obtained.
20 groups of males in their 40s to 50s, 5 groups of A, B, C, and D, 5 groups of A, B, C, and D, the tablet of Example 3 in group A, the tablet of Comparative Example 1 in group B, C The tablets of Comparative Example 2 were given to the group, and the tablets of Comparative Example 3 were taken to the D group, and 3 tablets were taken daily for 2 months after breakfast, and the scores at the start of the test and after 2 months were obtained and compared. According to the Ministry of Education, a 35cm-high platform is used, the tempo is 24 times / minute, the exercise time is 3 minutes, the chair is seated immediately after exercise, and the pulse is measured 3 times, 1 minute, 2 minutes, 3 minutes after exercise, The score was calculated from the sum by the following formula. The results are shown in Table 1.
Score = [(180 (seconds) / (total number of three pulses) × 2)] × 100

Test example (2)
The tablets obtained in Example 3 and Comparative Example 3 were subjected to the same test as in Test Example (1) except that the subjects were elderly people in their 60s and the intake period was 3 months. Asked. The results are shown in Table 2.

From the results of Test Example (1) and (2), (maintaining or improving agent of motor function of the present invention) tablet of Example 3 containing Coenzyme Q ₁₀ and carnitine is superior in maintenance and improvement of the body of motor function It can be seen that the effect is exhibited.

Test example (3)
The tablets obtained in Example 3 and Example 4 were subjected to the same test as in Test Example (2) except that the test subject was a female in the 60s, and the score was obtained. The results are shown in Table 3.

From the results of Test Example (3), by containing the organic acid in addition to coenzyme Q ₁₀ and carnitine, it can be seen that maintain and improve the effect of physical exercise function is further improved.

Test example (4)
Using the tablets obtained in Example 3 and Example 4, the stability test was performed as follows. The tablets were stored in a glass bottle package at 50 ° C., the appearance of the tablets was observed, and the changes were examined. The results are shown in Table 4.

  From the results of Test Example (4), it is understood that a stable tablet with little change in appearance can be obtained by containing an organic acid.

Claims (9)

Maintaining or improving agent of motor function of the coenzyme Q ₁₀ and carnitine as an active ingredient. Coenzyme Q ₁₀ was 00001-50 wt% 0. content of, maintaining or improving agent of motor function according to claim 1, wherein the content of carnitine is from 00,003 to 60% by weight 0.1. Blending ratio of the coenzyme Q ₁₀ and carnitine, maintaining or improving agent of motor function according to claim 1 or 2, wherein a 20 to 4000 parts by weight Carnitine to Coenzyme Q ₁₀ 100 parts by weight.   The agent for maintaining or improving motor function according to any one of claims 1 to 3, further comprising an organic acid as an active ingredient.   The agent for maintaining or improving motor function according to claim 4, wherein the organic acid is at least one selected from the group consisting of citric acid, succinic acid, fumaric acid, lactic acid, gluconic acid, malic acid and tartaric acid.   The agent for maintaining or improving motor function according to claim 4 or 5, wherein the content of the organic acid is 0.5 to 30% by mass. Blending ratio of the coenzyme Q ₁₀ and carnitine and organic acids, to coenzyme Q ₁₀ 100 parts by weight, carnitine 20-4000 parts by weight, to one of the claims 4-6 is 0.01 to 2000 parts by weight organic acids The agent for maintaining or improving the motor function described. The food / beverage products with which the maintenance or improvement agent of the motor function in any one of Claims 1-7 was mix | blended. A feed, a quasi-drug or a cosmetic containing the agent for maintaining or improving motor function according to any one of claims 1 to 7.