JP2005089348A - New microbicide composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a new microbicide composition that is negative in Ames and exhibits stable microbicidal effect in an aqueous system for a long period of time. <P>SOLUTION: The microbicide composition is obtained by formulating iodoacetamide with one or more kinds selected from isothiazolin-based compounds of (1) 2-methyl-4-isothiazolin-3-one, (2) 2-n-octyl-4-isothiazolin-3-one, (3) 1,2-benzisothiazolin-3-one, (4) 4,5-dicloro-2-n-octyl-4-isothiazolin-3-one and (5) N-butyl-1,2-benzisothiazolin-3-one. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention is a novel material that prevents microbial contamination of aqueous dispersions such as adhesives, resin emulsions, inks, glues, paints, paper, fibers and building materials used in various industrial fields and has no fear of environmental impact. A microbicidal composition.

In recent years, in aqueous dispersion products such as adhesives, resin emulsions, inks, glues, paints, paper, fibers, and building materials used in various industrial fields, and in the water systems of their manufacturing processes, they are contained in the water and products used for them. There is a problem in that various microorganisms, that is, bacteria, yeast, filamentous fungi, and algae grow by using organic compounds and trace inorganic substances as nutrients, and the quality and productivity of the product are significantly reduced. In order to address these problems, a wide variety of bactericides and bactericidal compositions have been added to products and the like. As such a bactericidal composition, for example, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (9: 1 mixture trade name manufactured by Chemicrea) : Zonen-F, Rohm & Haas 3: 1 mixture trade name: Kaeson LX SF25) (patent document 1) or a mixture of their metal complex salts (Chemclea 3: 1 mixture trade name) : Zonen-C, 3: 1 mixture manufactured by Rohm & Haas Co., Ltd., trade name: Kason WT), and these, for example, 2-bromo-2-nitropropane-1,3-dio -Bromo, 2,2-dibromo-2-nitro-1-ethanol, organic bromo compounds such as 1,2-bis (bromoacetoxy) ethane, and further methylene bis thiocyanate, 2- ( 4-thiocyanomethylthio ) Combination compounding agents such as benzothiazol and 1,2-benzisothiazolin-3-one are widely used (Patent Documents 2 and 3). However, both of these are positive in the Ames test and are mutagenic to the human body. Further, 2,2-dibromo-3-nitrilopropionamide, 2-bromo-2-nitropropane-1,3-diol, 2,2-dibromo-2-nitro-1-ethanol, 1,2 -In the case of a combination compounding agent in which an organic bromo compound such as bis (bromoacetoxy) ethane, or methylenebisthiocyanate, 2- (4-thiocyanomethylthio) benzothiazol or the like is compounded, Since both are diluted in solvents and used for general purposes, when used to prevent microbial contamination of aqueous dispersions, the solvents are volatilized into the atmosphere as volatile organic compounds (VOC), or the solvent flows into the aqueous system. As a result, there has been a problem that the COD (chemical oxygen demand) is increased and an environmental load is generated.
Japanese Patent Publication No.46-21240 Japanese Examined Patent Publication No. 60-54281 Japanese Patent Publication No.58-4682

  The present invention has been made in view of the above circumstances, and aims to provide a novel microbicidal composition which is Ames-negative and can exhibit a stable microbicidal effect over a long period of time in an aqueous system. is there.

As a result of various studies to develop a novel microbicidal composition, the present inventors have found that iodoacetamide and 2-methyl-4-isothiazolin-3-one, which have been used as conventional industrial fungicides, 2-n-octyl-4-isothiazolin-3-one, 1,2-benzisothiazolin-3-one, 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one, and N-butyl- Microbicidal agent that is Ames-negative and can exhibit a stable microbicidal effect over a long period of time in an aqueous system by incorporating one or more selected from the group consisting of 1,2-benzisothiazolin-3-one The present inventors have found that a composition can be prepared and have come to make the present invention based on this finding. That is, the present invention provides a novel microbicidal composition containing iodoacetamide and one or more selected from the following (1) to (5) isothiazoline compounds (1). ) 2-Methyl-4-isothiazolin-3-one (2) 2-n-octyl-4-isothiazolin-3-one (3) 1,2-benzisothiazolin-3-one (4) 4,5-dichloro- 2-n-octyl-4-isothiazolin-3-one (5) N-butyl-1,2-benzisothiazolin-3-one Preferably, the blending ratio of iodoacetamide and the entire isothiazoline-based compound is Based on 10: 1 to 1:10.

  The novel microbicidal composition of the present invention is Ames-negative by containing iodoacetamide and one or more selected from the above (1) to (5) isothiazoline compounds, and A stable microbicidal effect can be exhibited over a long period of time in an aqueous system. Therefore, the present invention enables the preparation of an aqueous microbicidal preparation that is stable over a long period of time without the problem of environmental burden.

  The iodoacetamide used in the present invention and the isothiazoline compounds (1) to (5) are widely used as industrial disinfectants and can be easily obtained as commercial products. The isothiazoline-based compounds (1) to (5) may be used alone or in combination of two or more.

  The blending ratio of iodoacetamide and the whole of the isothiazoline compounds (1) to (5) is preferably 50: 1 to 1:50, more preferably 10: 1 to 1:10, based on weight. More preferably 5: 1 to 1: 5. In the case of having such a blending ratio, a stable antiseptic effect can be exhibited particularly for a long period of time, but it is not limited to the above range as long as the object of the present invention can be achieved.

  In one embodiment of the invention, the microbicidal composition of the invention is in the form of an aqueous solution. The water used may be any of tap water, ion exchange water, distilled water, industrial water and the like, and is not particularly limited. The aqueous microbicidal composition solution of the present invention can be prepared by any known method for dissolving a bactericide in water. For example, iodoacetamide and one or more of the isothiazoline compounds (1) to (5) described above are added to water without a surfactant or together with a surfactant and mixed. An aqueous microbicidal composition solution of the invention can be prepared. As the surfactant, for example, any surfactant such as an anionic surfactant and a nonionic surfactant can be used.

  In another embodiment of the invention, the microbicidal composition of the invention is in the form of an aqueous dispersion. The water used is not particularly limited as in the case of the aqueous solution. The microbicidal composition dispersion of the present invention can be prepared by any known method for dispersing a bactericide in water. For example, iodoacetamide and one or more of the isothiazoline compounds (1) to (5) above are used together with an emulsifier, a dispersant, a filler, a viscosity modifier, an electrolyte, and / or an interfacial reinforcing agent. The microbicidal composition dispersion of the present invention can be prepared by adding to water, mixing, and further treating with an optional pulverizer such as a colloid mill, ball mill, sand mill, or bead mill. Examples of emulsifiers and dispersants include known surfactants such as anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymeric surfactants. Examples of the filler include silicic acid, bentonite, acid clay, clay, kaolin, and layered clay mineral. Examples of the viscosity modifier include carboxymethyl cellulose sodium salt, polyvinyl pyrrolidone, polyvinyl alcohol, guar gum, sodium alginate, gum arabic and the like. Examples of the electrolyte include inorganic compounds such as sodium chloride and potassium chloride, and organic compounds such as oxalic acid, tartaric acid, and maleic acid. Examples of the interfacial reinforcing agent include higher fatty acids such as stearic acid, higher alcohols such as cetanol, and hydrocarbons.

  The amount of addition of the novel microbicidal composition of the present invention varies depending on the microbial concentration, but is used in various industrial fields such as adhesives, resin emulsions, inks, glues, paints, paper, fibers and building materials. When used in an aqueous dispersion, it is about 20 to 500 ppm, and a particularly good microbicidal effect can be obtained in this range.

  The microbicidal composition of the present invention may further contain an optional stabilizer, buffering agent, etc. as necessary, as long as the object of the present invention is not hindered.

  EXAMPLES Next, although an Example demonstrates this invention still in detail, this invention is not limited at all by these examples.

In the formulation shown in Table 1, iodoacetamide and the indicated isothiazoline-based compound were dissolved or dispersed in water to prepare a microbicidal composition having the formulation shown in Table 1 (Examples 1 to 5, comparison) Examples 1-6)

  Each composition was subjected to the following tests.

(1) the bacterial growth prevention test strength agent 100ml in paper strength agent, the concentration is added 50 ppm, 100 ppm, so as to 300ppm each microbicidal compositions, pre rot (1ml per putrefactive bacteria number ¹⁰⁸⁾ 1 ml of the paper strength enhancer which had been allowed to be added was added and stored in a thermostat at 32 ° C. The number of viable bacteria in the paper strength enhancer was measured over time. The results are shown in Table 2:

(2) Bacteria growth prevention test in water-based paints Each microbicidal composition was added to 100 ml of water-based paints so that the concentration was 50 ppm, 100 ppm, and 300 ppm, and was previously spoiled (10 ⁸ spoilage bacteria per ml). 1 ml of water-based paint was added and stored in a thermostat at 32 ° C. The number of viable bacteria in the aqueous paint was measured over time. The results are shown in Table 3:

  As is apparent from these results, iodoacetamide and 2-methyl-4-isothiazolin-3-one, 2-n-octyl-4-isothiazolin-3-one, 1,2-benzisothiazolin-3-one, The present invention contains an isothiazoline compound selected from the group consisting of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one and N-butyl-1,2-benzisothiazolin-3-one The microbicidal compositions (Examples 1 to 5) in the aqueous system were able to show a high microbicidal effect over a long period of 4 weeks in a concentration range of 50 to 300 ppm in an aqueous system. On the other hand, in the composition containing only iodoacetamide (Comparative Example 1), the growth of bacteria was already observed at 2 weeks at 50 and 100 ppm, and the remarkable growth of bacteria was observed after 4 weeks even at 300 ppm. In addition, in the composition containing only the above isothiazoline-based compound (Comparative Examples 2 to 6), the growth of bacteria was already observed after 1 week, and after 2 weeks, the bacteria grew to almost the same level as the blank, and almost killed. The microbial effect could not be shown.

Claims (2)

Microbicidal composition comprising iodoacetamide and one or more selected from the following (1) to (5) isothiazoline compounds (1) 2-methyl-4-isothiazolin-3-one (2 ) 2-n-octyl-4-isothiazolin-3-one (3) 1,2-benzisothiazolin-3-one (4) 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one ( 5) N-butyl-1,2-benzisothiazolin-3-one.   The microbicidal composition according to claim 1, wherein the blending ratio of the iodoacetamide and the whole isothiazoline-based compound is 10: 1 to 1:10 based on weight.