JP2005075755A - Antiphlogistic-sedative plaster and method for producing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain an antiphlogistic-sedative plaster having enhanced effectiveness and safety, by making a conventional antiphlogistic-sedative plaster to contain "SHIUNKO" of Chinese medicine. <P>SOLUTION: This antiphlogistic-sedative plaster is characterized by containing the SHIUNKO of Chinese medicine in a substrate containing a skin irritant. The SHIUNKO is preferably compounded in an amount of 5 to 50 wt. %. At least one selected from indomethacin, ketoprofen, flurbiprofen, felbinac, capsicum extract, nonylic acid vanillylamide, menthol, camphor, methyl salicylate, and glycol salicylate is contained in the substrate as the skin irritant. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to an anti-inflammatory analgesic patch and a method for producing the same.

  Shiunko is said to be an ointment devised by Hanaoka Aoshima, and works particularly well for eczema, psoriasis, keratoderma, cracks, scabs, rashes, burns, and wrinkles. In addition, athlete's foot, corn, octopus, acne, warts It is a medicine that is useful when it is at hand, and is effective for various skin diseases such as alopecia areata, trauma, frostbite, ulcer, and anal prolapse.

Usually, the following composition and amount are used as the material for the purple cloud.
Sesame oil ... 1000g
Beeswax ... 300g
Pork oil ... 30g
Togo ... 80g
Murasakine ... 120g

  To make it, first boil sesame oil and dissolve beeswax and pork oil. Next, add a return and keep at 140 ° C. Add purple root to this and boil for 15 minutes while maintaining 140 ° C. Filter the boiled material with a cloth and mix slowly with stirring to harden. Beeswax is often in summer and less in winter.

  As a patch using this purple cloud plaster, a paste sheet layer containing at least one of purple cloud paste, lysozyme chloride, and sugar is supported on a resin sheet base layer made of a flexible resin having air permeability. A patch for treatment of acne or the like has already been proposed (see, for example, Patent Document 1). However, this known patch is a patch for treating pressure ulcers and the like, and is simply a purple cloud for treating pressure ulcers blended in the plaster layer.

  On the other hand, anti-inflammatory analgesic patches containing anti-inflammatory analgesic ingredients to suppress inflammation such as low back pain, stiff shoulders, and muscle pain are widely marketed. These are broadly classified into warm patches and cold patches, and warm patches are used several days after the onset of chronic low back pain or acute low back pain, and cold patches suppress local fever caused by inflammation. At the same time, it is used for the purpose of preventing the spread of inflammatory sites.

  These two types of patches will be explained from the components. The warm patch contains a pepper extract, nonyl acid vanillylamide, and the like that gives the skin a warm feeling. Capsicin, which is a pungent component of capsicin, is a local blood vessel. By expanding the blood flow in the affected area, the damaged tissue can be repaired more quickly, or low back pain due to lumbar muscle blood flow disturbance can be improved. Nonylic acid vanillylamide is a derivative of capsaicin and improves blood circulation by the same mechanism.

  The cooling patch contains refreshing components such as menthol and camphor, which suppresses local fever caused by inflammation and prevents the inflammation from spreading. In addition, since menthol and the like act on the periphery of sensory nerves to cause mild sensory paralysis, an analgesic action can be expected, and it is often used in the acute phase of inflammatory pain diseases.

Registered Utility Model No. 3036689

  As described above, the anti-inflammatory analgesic patch contains skin irritation ingredients such as capsicum extract, nonyl acid vanillylamide, menthol and camphor in addition to indomethacin, ketoprofen, flurbiprofen, felbinac, etc. For those who are sensitive, the skin itself may be irritated by applying an anti-inflammatory analgesic patch. In particular, warm patches have strong skin irritation, rash side effects such as redness and rash are likely to appear, and the site applied at the time of bathing sometimes hurts strongly.

  According to the present invention, the effectiveness and safety can be enhanced by including the traditional anti-inflammatory analgesic patch containing “Shiunko” as a Chinese medicine. Specifically, anti-oxidation or oxidation delay effect and reduction of rash caused by sticking, mitigation of drug irritation, imparting proper sticking power to sticking base, reducing keratinous damage to moderate sticking force, The purpose is to protect the skin positively by certain Toki and Shikon.

  The anti-inflammatory analgesic patch according to the invention described in claim 1 is characterized in that the base containing a skin irritant component contains a Chinese medicine prescription Shiunko.

  The anti-inflammatory analgesic patch according to the invention described in claim 2 is characterized in that the base of claim 1 is a plaster.

  The anti-inflammatory analgesic patch according to the invention described in claim 3 is characterized in that shiunko is blended in the base of claim 1 or 2 in a weight ratio of 5% or more and less than 50%. is there.

  The anti-inflammatory analgesic patch according to the invention described in claim 4 is a skin irritation component according to any one of claims 1 to 3, wherein indomethacin, ketoprofen, flurbiprofen, felbinac, red pepper extract, nonylic acid One or more components selected from vanillyl amide, menthol, camphor, methyl salicylate and glycol salicylate are contained in the base.

  The anti-inflammatory analgesic patch according to the invention described in claim 5 is characterized in that 0.001 to 0.5% by weight of nonyl acid vanillylamide is contained in the base as a skin irritation component according to claim 4. It is.

The method for producing an anti-inflammatory analgesic patch according to the invention described in claim 6 is the method for producing an anti-inflammatory analgesic patch according to any one of claims 1 to 5,
The heat-kneaded base is left to stand in a cool and dark place for 2 to 4 days, and then a base layer composed of the base is formed on a support and then left to stand in a cool and dark place for 2 to 4 days. .

  As described above, according to the present invention, the effectiveness and safety can be improved by including the traditional anti-inflammatory analgesic adhesive in the form of Chinese medicine “Shiunko”. Specifically, anti-oxidation or oxidation delay effect and reduction of rash caused by sticking, alleviation of drug irritation, imparting proper sticking force to sticking base, reducing keratin damage to moderate sticking force In addition, there is an effect that an active protective action can be obtained on the skin by Toki and Sikon, which are components of purple cloud.

  Since the anti-inflammatory analgesic patch according to the present invention comprises Kampo-formed purple cloud plaster in a base containing a skin irritant component, the effectiveness and safety as an anti-inflammatory analgesic can be improved, and oxidation It can prevent or reduce the oxidation delay effect and rash caused by sticking.

  As a base in the patch of the present invention, it means to contain either a poultice or a plaster, but in the case of a poultice having a high water content, purple cloud with a lot of oily components is stably dispersed in the base. Plasters are preferred because they are difficult to retain and are therefore in terms of formulation and product stability.

  In the patch of the present invention, it is preferable that the blending ratio of shimo-gypsum added to the base is 5 or more and less than 50% by weight in the base. If it is less than 5% by weight, the effect of Shimo-gaku on skin diseases cannot be demonstrated, and if it is added in an amount of 50% by weight or more, support for the combination of suitable anti-inflammatory and analgesic ingredients is produced, and the adhesive strength to the skin is also reduced. become.

  The skin irritation component in the patch of the present invention is based on one or more components selected from indomethacin, ketoprofen, flurbiprofen, felbinac, capsicum extract, nonyl acid vanillylamide, menthol, camphor, methyl salicylate, and salicylate glycol. What is contained in the agent is mentioned. Even if these skin-irritating ingredients are contained, the purple cloud contained simultaneously exhibits a synergistic effect of reducing rash. More specifically, even if nonylic acid vanillylamide as a skin irritant component is contained in the base in an amount of 0.001 to 0.5% by weight, violet cloud can reduce rash.

  The anti-inflammatory analgesic patch of the present invention is because the beeswax is blended in the purple cloud paste component, or the base is heat-kneaded with a heating kneader or the like, and the base becomes soft and has a large adhesive strength. became. Therefore, in the method for producing an anti-inflammatory analgesic patch of the present invention, after the heated and kneaded base is left in a cool and dark place for 2 to 4 days, a base layer composed of the base is formed on the support, A step of leaving it in a cool and dark place for 4 days is provided. As a result, the anti-inflammatory analgesic patch has an appropriate hardness and an appropriate adhesiveness.

Example A.1. Manufacture of anti-inflammatory analgesic patches 1
As a comparative example 1, as a working example, Shimogyo was blended with 5 wt% (Example 1), 20 wt% (Example 2), 33 wt% (Example 3), and 50 wt% (Example 4). The thing which does not mix | blend Shimo-gypsum was created. Specifically, an anti-inflammatory analgesic patch is produced by heating and mixing the composition shown in the following Table 1 to prepare a plaster base, rolling and applying with a roll (calendar) roll, and cutting the release paper on top of each other. did.

  In addition, as Comparative Example 1, a comparative example was prepared in which toki soft extract and shikon soft extract were added and other base components were substantially the same. As a skin irritating component, L-menthol, nonyl acid vanillylamide, and methyl salicylate are added.

  A more specific manufacturing process is as follows. First, a plaster base was prepared with a kneader. Specifically, a rubber base made of raw rubber, polyisobutylene, titanium oxide, calcium carbonate, and terpene resin is put into a kneader at 80 ° C. to 100 ° C. and kneaded, and then polybutene, ester gum, methyl acrylate / acrylic acid A tackifier comprising 2-ethylhexyl copolymer resin emulsion and natural rubber latex was added and kneaded.

  Active ingredients of L-menthol, methyl salicylate, nonylic acid vanillylamide, and Shimogaku (or Toki soft extract, Shikon soft extract) were added to the obtained plaster base and kneaded to complete the plaster base. . Then, the anti-inflammatory analgesic patch was obtained by apply | coating uniformly on a support body by rolling application | coating by a rolling (calendar) roll, piled up a release paper, and cut | judging to a desired shape. In addition, the drug which expects a medicinal ingredient is mixed and added to the emulsifying base. Alternatively, the plaster base may be roll-coated on a heat-resistant release paper, and then the support may be overlaid and cut into a desired shape.

  However, although the details of the anti-inflammatory analgesic agent obtained are due to the inclusion of beeswax in the purple cloud paste component, the base is candy-like and soft, and the adhesive strength is enormous. Use was unsuitable. Therefore, the process was devised.

  FIG. 1 is a process diagram showing the production process of the anti-inflammatory analgesic patch of the present invention. As shown in the figure, the plaster base kneaded with a kneader was once left in a cool and dark place for 2 to 4 days. Thereafter, the anti-inflammatory analgesic patch applied by rolling the plaster base with a rolling (calendar) roll and cut by overlapping release paper was left again in a cool and dark place for 2 to 4 days. In addition, as a rolling application | coating process, the rolling roll was lowered | hung from normal 95 degreeC to 85 degreeC. As a result, since the obtained anti-inflammatory analgesic patch had an appropriate hardness and an appropriate adhesiveness, it was used as a product.

Example B. Characteristics of anti-inflammatory analgesic patch Using the anti-inflammatory analgesic patch shown in Table 1, it was applied to the arm for 10 hours for 10 subjects, and the following items were observed. Regarding observation items: 1. Adhesion to the skin 2. Effective feeling; 3. Pain when peeling; It was the state of the skin after peeling, and for each, a score was given for the corresponding item and each was calculated. The results are shown in the following Tables 2 to 5.

  As shown in Table 2, even in the case of purple gypsum blended with fats and oils, there was no significant difference in sticking property with 5% to 33% blending. Declined. Moreover, although the compounding ratio of the tackifier to the rubber base was the same, there is no support for the adhesiveness if the amount of purple cloud is less than 50%. It turns out that it has acquired adhesiveness.

  The effect feeling is, if briefly explained, a sensation obtained by stimulating the skin when the skin irritation component is adhered, and as shown in Table 3, there is no difference in the drug itself related to the effect feeling. It was confirmed that there was almost no difference between the comparative example and Examples 1, 2, and 3.

  As shown in Table 4, the pain at the time of exfoliation in the comparative example was not caused solely by the adhesive strength, but it was thought that rash was one of the causes as judged from the skin condition described later. As for the examples, since the purple cloud containing the fat and oil component is blended, the adhesiveness tends to be inhibited accordingly, so there was no pain at the time of peeling, and the adhesiveness was moderately reversed. I thought it was.

  In addition, as shown in Table 5, the skin irritation component was the same, whereas the blend containing shiunko was not damaged to the extent that the keratin was peeled off.

Example C. Manufacture of anti-inflammatory analgesic patches 2
In Example A, as a skin irritant component, d1 monoflux, L-menthol, nonylic acid vanillylamide, and methyl salicylate were added, but other anti-inflammatory analgesic patches include indomethacin and L-mento Another anti-inflammatory analgesic patch to which was added was prepared. Specifically, anti-inflammatory analgesic patches were prepared with the compositions shown in Table 6 below.

  In addition, as Comparative Example 2, a comparative example was prepared by adding toki soft extract and sycon soft extract to make the other base components substantially the same, and the characteristics of the anti-inflammatory analgesic patch were verified in the same manner as in Example 2. As in Example B, in Comparative Example 2, damage to the extent that the keratin was peeled occurred, whereas in Example 5, there was no damage to the extent that the keratin was peeled off.

It is process drawing which showed the manufacturing process of the anti-inflammatory analgesic patch of this invention.

Claims (6)

  An anti-inflammatory analgesic patch characterized by containing Kampo-prescription shiungaku in a base containing a skin irritation component.   The anti-inflammatory analgesic patch according to claim 1, wherein the base is a plaster.   3. The anti-inflammatory analgesic patch according to claim 1 or 2, wherein the base is formulated with 5% or more and less than 50% by weight.   As a skin irritation component, the base contains one or more components selected from indomethacin, ketoprofen, flurbiprofen, felbinac, pepper extract, nonyl acid vanillylamide, menthol, camphor, methyl salicylate, and salicylate glycol. The anti-inflammatory analgesic patch according to any one of claims 1 to 3.   The anti-inflammatory analgesic patch according to claim 4, wherein 0.001 to 0.5% by weight of nonyl acid vanillylamide is contained in the base as a skin irritation component. In the method for producing an anti-inflammatory analgesic patch according to any one of claims 1 to 5,
An anti-inflammatory analgesic patch characterized in that after the heat-kneaded base is left in a cool dark place for 2 to 4 days, a base layer comprising the base is formed on a support and then left in a cool dark place for 2 to 4 days. Manufacturing method.

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